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Annals of Pediatric Endocrinology & Metabolism

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https://www.readbyqxmd.com/read/29969884/de-novo-a-novel-variant-of-casr-gene-in-a-neonate-with-congenital-hypoparathyroidism
#1
Jung-Eun Moon, Su-Jeong Lee, Suk-Hyun Park, Jinsup Kim, Dong-Kyu Jin, Cheol Woo Ko
Autosomal-dominant hypocalcemia with hypercalciuria (ADHH) is a genetic disease characterized by hypoparathyroidism with hypercalciuria. Most patients with ADHH have calcium-sensing receptor (CaSR) gene mutations. The CaSR gene controls parathyroid secretions, and mutations in this gene can be detected via changes in serum calcium level. The activating mutation of the CaSR gene results in familial or sporadic ADHH. Most activating mutations of the CaSR gene are reportedly de novo missense mutations. This is the first case report of a novel activating variant of the CaSR gene in a neonate with congenital hypoparathyroidism with hypomagnesemia and hypercalciuria...
June 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29969883/respiratory-failure-in-a-diabetic-ketoacidosis-patient-with-severe-hypophosphatemia
#2
Han Saem Choi, Ahreum Kwon, Hyun Wook Chae, Junghwan Suh, Duk Hee Kim, Ho-Seong Kim
Phosphate is essential in regulating human metabolic processes, and severe hypophosphatemia can induce neurologic and hematological complications and result in respiratory failure and cardiac dysfunction. Therefore, correction of severe hypophosphatemia can be pivotal in the management of diabetic ketoacidosis (DKA). We report the case of a 14-year-old female who was diagnosed with type 1 diabetes and referred to our institute for treatment of DKA. Although the patient received fluid and continuous insulin administration according to the current DKA treatment protocol, generalized tonic seizures and cardiac arrest developed...
June 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29969882/association-kikuchi-disease-with-hashimoto-thyroiditis-a-case-report-and-literature-review
#3
Eun Joo Lee, Hae Sang Lee, Jun Eun Park, Jin Soon Hwang
Kikuchi-Fujimoto disease (KFD) is a benign and self-limited disease characterized by fever and lymphadenopathy. The etiology of KFD is unknown, but an autoimmune cause has been suggested. Hashimoto thyroiditis is the most common autoimmune thyroid disorder in children and is known to be associated with other autoimmune diseases. Only a few cases of Hashimoto thyroiditis associated with KFD have been documented. We report a case of a 16-year-old girl who was first diagnosed with KFD and developed Hashimoto thyroiditis 2 years and 6 months later during her follow-up period...
June 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29969881/cancer-in-thyroid-nodules-with-fine-needle-aspiration-in-korean-pediatric-populations
#4
Joon Ho Jang, So Hyun Park, Kyung Soon Cho, Won Kyung Cho, Young Jin Suh, Byung Kyu Suh, Dae Kyun Koh
PURPOSE: To determine the prevalence and clinical findings of benign thyroid nodules and cancer in Korean pediatric patients with thyroid nodules. METHODS: We investigated the medical records of 134 patients aged younger than 18 years who had a goiter, thyroid nodule, thyroid mass, or thyroid cancer who underwent fine needle aspiration biopsy (FNAB). RESULTS: The study population included 113 females (84.3%) and 21 males (13.7%); the mean patient age was 16...
June 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29969880/thyroid-dysfunction-in-patients-with-childhood-onset-medulloblastoma-or-primitive-neuroectodermal-tumor
#5
Seung Young Jin, Jung Yoon Choi, Kyung Duk Park, Hyoung Jin Kang, Hee Young Shin, Ji Hoon Phi, Seung-Ki Kim, Kyu-Chang Wang, Il Han Kim, Young Ah Lee, Choong Ho Shin, Sei Won Yang
PURPOSE: We investigated the clinical characteristics of patients who developed thyroid dysfunction and evaluated the risk factors for hypothyroidism following radiotherapy and chemotherapy in pediatric patients with medulloblastoma or primitive neuroectodermal tumor (PNET). METHODS: The medical records of 66 patients (42 males) treated for medulloblastoma (n=56) or PNET (n=10) in childhood between January 2000 and December 2014 at Seoul National University Children's Hospital were retrospectively reviewed...
June 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29969879/visceral-fat-thickness-and-its-associations-with-pubertal-and-metabolic-parameters-among-girls-with-precocious-puberty
#6
Dong Wook Kim, Junghwan Suh, Ah Reum Kwon, Hyun Wook Chae, Choon Sik Yoon, Ho-Seong Kim, Duk Hee Kim
PURPOSE: This study aimed to investigate associations of central obesity with sexual maturation and metabolic parameters in Korean girls with precocious puberty. METHODS: This retrospective study evaluated data from 72 girls under 8 years of age with a chief complaint of early breast development. The patients were categorized as central precocious puberty (CPP) subjects or non-CPP subjects based on their gonadotropin-releasing hormone stimulation test results. Visceral fat thickness (VFT) was measured using ultrasonography and defined as the distance from the linea alba to the aorta...
June 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29969878/etiological-trends-in-male-central-precocious-puberty
#7
Jisun Lee, Jinsup Kim, Aram Yang, Sung Yoon Cho, Dong-Kyu Jin
PURPOSE: In the present study, the etiological trends in male central precocious puberty (CPP) were examined, and annual distribution was evaluated. METHODS: Seventy-one male CPP subjects who started puberty before 9 years of age were included in this study. All individuals were diagnosed as having CPP at Samsung Medical Center between 2001 and 2016. Chronological age at puberty onset, diagnosis of CPP, bone age, weight (kg), height (cm), puberty stage, brain magnetic resonance imaging findings, testosterone level, basal gonadotropin level, and gonadotropin level after gonadotropin releasing hormone stimulation were analyzed...
June 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29969877/fertility-preservation-in-pediatric-and-young-adult-female-cancer-patients
#8
Hashin Kim, Hoon Kim, Seung-Yup Ku
As the 5-year survival rate increases up to 80% in pediatric cancer patients, the number of women patients with reduced gonadal function by chemotherapy and radiotherapy increases. The gonadal toxicity of pediatric patients varies highly according to the chemotherapeutic agent and the type of radiotherapy. Although American Society of Clinical Oncology published the guideline for fertility preservation, additional scientific and ethical concerns should be considered for clinical practice. In addition, only the experimental method can be applied for the prepubertal patients in contrast to the postpubertal patients...
June 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29969876/fat-and-bone-in-children-where-are-we-now
#9
Paul Dimitri
The risk of fracture secondary to low-impact trauma is greater in obese children, suggesting obese children are at risk of skeletal fragility. However, despite this finding, there is a lack of agreement about the impact of excessive adiposity on skeletal development. The combination of poor diet, sedentary lifestyle, greater force generated on impact through falls, and greater propensity to falls may in part explain the increased risk of fracture in obese children. To date, evidence suggests that in early childhood years, obesity confers a structural advantage to the developing skeleton...
June 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29969875/delayed-puberty-versus-hypogonadism-a-challenge-for-the-pediatrician
#10
Mauro Bozzola, Elena Bozzola, Chiara Montalbano, Filomena Andreina Stamati, Pietro Ferrara, Alberto Villani
Constitutional delay of growth and puberty (CDGP) is the most common cause of delayed puberty (DP), is mainly found in males, and is characterized by short stature and delayed skeletal maturation. A family history of the subject comprising the timing of puberty in the parents and physical examination may provide clues regarding the cause of DP. Delayed onset of puberty is rarely considered a disease in either sex. In fact, DP usually represents a common normal variant in pubertal timing, with favorable outcomes for final height and future reproductive capacity...
June 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29609451/erratum-the-effect-of-first-nocturnal-ejaculation-timing-on-risk-and-sexual-behaviors-of-korean-male-adolescents
#11
Mi-Ji Lee, Go-Eun Yang, Hee Won Chueh, Jae Hong Park, Jae-Ho Yoo
[This corrects the article on p. 43 in vol. 22.].
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29609450/hepatopulmonary-syndrome-caused-by-hypothalamic-obesity-and-nonalcoholic-fatty-liver-disease-after-surgery-for-craniopharyngioma-a-case-report
#12
Dai Jung, Go Hun Seo, Yoon-Myung Kim, Jin-Ho Choi, Han-Wook Yoo
Hypothalamic obesity is often complicated in patients with craniopharyngioma due to hypothalamic damage by the tumor itself, treatment modalities, and associated multiple pituitary hormone deficiency. Hypothalamic obesity causes secondary diseases such as nonalcoholic fatty liver disease (NAFLD) and diabetes mellitus (DM). We report a 19-year-old female who was diagnosed with craniopharyngioma, developed hypothalamic obesity after tumor resection, and progressed to hepatopulmonary syndrome. She manifested NAFLD 1 year after tumor resection...
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29609449/design-of-the-long-term-observational-cohort-study-with-recombinant-human-growth-hormone-in-korean-children-lg-growth-study
#13
Sochung Chung, Jae-Ho Yoo, Jin Ho Choi, Young-Jun Rhie, Hyun-Wook Chae, Jae Hyun Kim, Il Tae Hwang, Choong Ho Shin, Eun Young Kim, Kee-Hyoung Lee
PURPOSE: Regarding recombinant human growth hormone (rhGH) use in the pediatric population, no long-term follow-up data are available for Korean patients. To fill in the gap of knowledge, a registry study (LG Growth Study) was initiated to assess the safety and effectiveness of four types of rhGH products in real-life settings. METHODS: A total of 4,000 children will be registered and prospectively followed up at 6-month intervals until 2 years after epiphyseal closure to collect data on treatment and adverse events, with primary interest in malignancies and growth outcomes...
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29609448/the-relationship-between-subclinical-hypothyroidism-and-serum-levels-of-uric-acid-and-creatinine-in-children-aged-2-14-years
#14
Saba Sayari, Ziba Molaei, Zohre Torabi
PURPOSE: Hypothyroidism is a clinical syndrome that can lead to elevated levels of serum creatinine and uric acid by causing impaired renal function. Although many studies have been carried out on the relationship between overt hypothyroidism and renal function, few studies have been conducted on subclinical hypothyroidism and renal function, especially in pediatric patients. For this reason, we studied this issue in children, so as to provide a background for more useful research and future education...
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29609447/prevalence-of-autoimmune-thyroiditis-in-patients-with-type-1-diabetes-a-long-term-follow-up-study
#15
Gum Bit Hwang, Jong Seo Yoon, Kyu Jung Park, Hae Sang Lee, Jin Soon Hwang
PURPOSE: Type 1 diabetes mellitus (DM) is associated with autoimmune diseases such as thyroiditis. Therefore, we aimed to investigate the prevalence of autoimmune thyroiditis in patients with type 1 DM. METHODS: A total of 102 patients who were diagnosed and followed up (mean age, 8.1±4.0 years) in Ajou University Hospital were enrolled in this study. All the patients were evaluated for beta cell autoimmunity, including insulin autoantibody, glutamic acid decarboxylase antibodies (GADA), and islet cell antibody...
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29609446/near-final-height-in-korean-children-referred-for-evaluation-of-short-stature-clinical-utility-and-analytical-validity-of-height-prediction-methods
#16
Seung Woo Jeong, Ja Hyang Cho, Hae Woon Jung, Kye Shik Shim
PURPOSE: Predicted adult height (PAH) is often crucial to decision-making about treatment with human growth hormone (GH) or gonadotropin-releasing hormone agonist in children with short stature. This study compares final adult height (FAH) with different methods used to determine PAH and assesses the clinical utility and analytical validity of height prediction for children not treated with GH. METHODS: Clinical findings were retrospectively analyzed, and the heights of 44 children (22 males and 22 females) who visited our clinic between August 2006 and June 2017 and reached near final adult height (NFAH) were evaluated...
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29609445/low-levels-of-25-hydroxyvitamin-d-in-children-and-adolescents-with-type-1-diabetes-mellitus-a-single-center-experience
#17
Ki Nam Bae, Hyo-Kyoung Nam, Young-Jun Rhie, Dae Jin Song, Kee-Hyoung Lee
PURPOSE: Low vitamin D level is common in adults with diabetes mellitus (DM). We assessed vitamin D level and its associated factors in Korean youth with type 1 DM. METHODS: Type 1 DM cases (n=85) and healthy controls (n=518) aged <20 years were included and grouped into 3 categories according to vitamin D level: deficiency (<20 ng/mL), insufficiency (20-30 ng/mL), or sufficiency (≥30 ng/mL). RESULTS: The mean serum vitamin D level was significantly lower (21...
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29609444/small-for-gestational-age-and-obesity-epidemiology-and-general-risks
#18
REVIEW
Hyo-Kyoung Nam, Kee-Hyoung Lee
Children born small for gestational age (SGA) have several life-long consequences. Previous epidemiological studies investigated from childhood to adulthood reported that a number of chronic diseases originate in the prenatal period. With the emerging era of obesity epidemic, more concerns are related to being obese than being short-statured in SGA children. The exact mechanisms are uncertain; however, growth hormone-insulin-like growth factor axis disturbance by fetal programming and accelerated postnatal weight gain contributed to central adiposity in SGA children...
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29609443/small-for-gestational-age-and-obesity-related-comorbidities
#19
REVIEW
Yong Hee Hong, Sochung Chung
Infant born small for gestational age (SGA) are at increased risk of perinatal morbidity, persistent short stature and metabolic alterations in later life. The result of SGA followed by rapid weight gain during early postnatal life has been associated with increased long-term risks for central obesity, insulin resistance, impaired glucose tolerance, type 2 diabetes, hypertension, increased fat mass, and cardiovascular disease. We should carefully monitor their weight during infancy and childhood to prevent excessive rates of weight gain...
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29609442/adherence-of-the-annals-of-pediatric-endocrinology-metabolism-to-the-principles-of-transparency-and-best-practice-in-scholarly-publishing
#20
Sun Huh
No abstract text is available yet for this article.
March 2018: Annals of Pediatric Endocrinology & Metabolism
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