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Journal of Epilepsy Research

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https://www.readbyqxmd.com/read/28101484/cadasil-initially-presented-with-a-seizure
#1
Jung-Hwan Oh, Bong Su Kang, Jay Chol Choi
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary disease of the cerebral small blood vessels characterized by recurrent ischemic strokes, migraine, and progressive cognitive impairment. In patients with CADASIL, in whom subcortical white matter structures are typically involved, epileptic seizures have been rarely reported as an initial clinical symptom. We describe a patient genetically confirmed as having CADASIL who initially presented with a seizure...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28101483/intermittent-theta-slowings-in-contralateral-side-of-weakness-after-sleep-deprivation-on-spot-eeg-in-sporadic-hemiplegic-migraine
#2
Chan-Hyuk Lee, Man-Wook Seo, Byoung-Soo Shin, Tae-Ho Yang, Hyun-June Shin, Han Uk Ryu
Hemiplegic migraine (HM) is an uncommon type of migraine which is classified into sporadic and familial subtype. The noticed electroencephalogram (EEG) findings during HM attack are diffuse slowing contralateral to the weakened limb, but are usually normal in asymptomatic states. A 52-year-old woman who suffered from headache accompanying right arm weakness and aphasic symptoms admitted to our hospital. She underwent total five times of EEG including 2 times before admission. Only the last EEG exam after 24 hours of sleep deprivation (SD) showed intermittent slowing and higher amplitude of positive occipital sharp transients (POSTs) on the left parieto-occipital area...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28101482/cefepime-induced-non-convulsive-status-epilepticus-in-a-patient-with-normal-renal-function
#3
Hyeon-Mi Park, Young Noh, Ji Won Yang, Dong Hoon Shin, Yeong-Bae Lee
Cefepime-induced encephalopathy including nonconvulsive status epilepticus has been known to develop in the patients with renal impairment. However, we report a 74-year-old woman with normal renal function who developed stuporous mental status during cefepime administration. Electroencephalogram (EEG) revealed 2 Hz rhythmic sharp-and-waves continuously, which suggested nonconvulsive status epilepticus (NCSE). After cefepime discontinuation, clinical symptoms recovered gradually and EEG findings showed only background slowing without epileptiform discharges...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28101481/evaluation-of-ictal-consciousness-in-temporal-and-extra-temporal-epilepsy-observations-from-a-tertiary-care-hospital-in-india
#4
Rima M Chaudhari, Deepa Dash, Bhargavi Ramanujam, Manit K Rana, Renjith Appukuttan, Anubha Sharma, Yuvraj Kunwar, Gaurav Tejaniya, Vasantha Padma, Sarat P Chandra, Manjari Tripathi
BACKGROUND AND PURPOSE: Differences in consciousness during seizures depend on the location of the seizure onset. METHODS: The present study evaluates ictal consciousness using the ictal consciousness inventory (ICI) in drug refractory mesial temporal (MTLE), neocortical temporal (NTLE) and extra temporal epilepsy (ETLE). This was a cross sectional cohort study with 45 patients with mesial temporal epilepsy, 47 with extra temporal and 11 patients with neocortical temporal epilepsy...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28101480/spectrum-of-cutaneous-adverse-reactions-to-levetiracetam-and-human-leukocyte-antigen-typing-in-north-indian-patients
#5
Bhargavi Ramanujam, Kavish Ihtisham, Gurvinder Kaur, Shivani Srivastava, Narinder Kumar Mehra, Neena Khanna, Mahip Singh, Manjari Tripathi
BACKGROUND AND PURPOSE: Aromatic antiepileptic drugs are frequently implicated for cutaneous adverse drug reactions (cADRs); there are case-reports of even severe reactions like drug reaction eosinophilia and systemic symptoms (DRESS) and Stevens Johnson syndrome (SJS)-toxic epidermal necrolysis with Levetiracetam (LEV). Certain human leukocyte antigen (HLA)-alleles have strong association with cADRs due to specific drugs - HLA-B*15:02 and HLA-A*31:01 in Carbamazepine (CBZ)-related SJS in Han-Chinese and European populations, respectively...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28101479/excessive-daytime-sleepiness-and-sleep-disorders-in-a-population-of-patients-with-epilepsy-a-case-control-study
#6
Matilde Gammino, Leila Zummo, Anna Lo Bue, Lidia Urso, Valeria Terruso, Oreste Marrone, Brigida Fierro, Ornella Daniele
BACKGROUND AND PURPOSE: There are several primary causes for excessive daytime sleepiness (EDS) and sleep disorders in patients with epilepsy. Up to now, studies in the literature report conflicting data in terms of both prevalence and aetiology. The aim of our study was therefore to evaluate the prevalence of EDS and some sleep disorders in a population of patients with epilepsy treated with no more than two antiepileptic drugs (AEDs). We also investigated the role of the depression of mood as a variable that can negatively affect EDS...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28101478/focal-epileptogenic-lesions-in-adult-patients-with-epilepsy-and-generalized-epileptiform-discharges
#7
Dong Wook Kim, Seo-Young Lee, Sang Kun Lee
BACKGROUND AND PURPOSE: There are reports of successful resective epilepsy surgery for pediatric patients with epilepsy and generalized epileptiform discharges when they had focal epileptogenic lesions identified by MRI. However, there is limited information regarding adult patients with epilepsy who have both generalized epileptiform discharges and focal epileptogenic lesions. METHODS: To investigate the incidence and characteristics of adult patients who have both generalized epileptiform discharges and potentially epileptogenic lesions, we retrospectively analyzed data of clinical features and results of EEG and MRI of all patients with adult-onset epilepsy in a tertiary referral hospital...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28101477/change-of-patient-selection-strategy-and-improved-surgical-outcome-in-mri-negative-neocortical-epilepsy
#8
Hye-Jin Moon, Dong Wook Kim, Chun-Kee Chung, Jung-Won Shin, Jangsup Moon, Bong Su Kang, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Ki-Young Jung, Yong Won Cho, Sang Kun Lee
BACKGROUND AND PURPOSE: It is crucial to make selection strategy to identify surgical candidates among medically refractory MRI-negative neocortical epilepsy patients. In our previous study, we suggested two or more concordance between noninvasive studies (EEG, ictal scalp EEG, interictal FDG-PET, and SPECT) as a new patient selection strategy for MRI-negative neocortical epilepsy surgery. The objective of this study was to evaluate the surgical outcomes of MRI-negative neocortical epilepsy patients before and after the implementation of a new selection strategy...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28101476/psychometric-properties-of-the-persian-version-of-the-quality-of-life-in-epilepsy-inventory-in-the-later-life
#9
Abdolrahim Asadollahi, Laleh Fani Saberi, Ali Havasi, Mohammad-Hossein Kaveh
BACKGROUND AND PURPOSE: The reports indicate on the incidence of seizure disorder about 1.5 per cent of the normal elderly population. The Quality of Life in Epilepsy Inventory (QOLIE-31) has been pervasive simple tool to screen seizure in the busy neurophysiological settings and monitoring. It was constructed as self-administered tool in two formats, 89 and 31-items. To the reliability and validity of the QOLIE-31 across older adults in the southwest Iran and discuss its role in the detection of health-related quality of elderly patients with epilepsy...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28101475/anticonvulsive-effects-of-licofelone-on-status-epilepticus-induced-by-lithium-pilocarpine-in-wistar-rats-a-role-for-inducible-nitric-oxide-synthase
#10
Seyyed Majid Eslami, Mohammad Mobin Moradi, Mehdi Ghasemi, Ahmad Reza Dehpour
BACKGROUND AND PURPOSE: Status epilepticus (SE) is a neurological disorder with high prevalence and mortality rates, requiring immediate intervention. Licofelone is a cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor, which its effectiveness to treat osteoarthritis has been approved. Increasing evidence suggests an involvement of COX and LOX enzymes in epileptic disorders. Thus, in the present study we investigate possible effects of licofelone on prevention and termination of SE...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28101474/the-laboratory-diagnosis-of-autoimmune-encephalitis
#11
REVIEW
Sang Kun Lee, Soon-Tae Lee
Autoimmune encephalitis is a group of encephalitis syndromes that cause altered mentality, memory decline, or seizures in association with the presence of serum and cerebrospinal fluid (CSF) autoantibodies (auto-Abs). An early diagnosis enables early treatments. The detection of auto-Abs is a confirmatory diagnosis. Tissue-based assay, cell-based immunoassay, and immunoblotting are used to detect various autoantibodies. The CSF test for the presence of antibodies is important because it is more sensitive and reflects disease activity in many autoimmune encephalitis, although antibody tests can be negative even in the presence of autoimmune encephalitis...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/27390681/atrophy-is-a-real-phenomenon-that-can-result-in-changes-in-deep-brain-stimulation-outcome
#12
Daniel Martinez-Ramirez, Kelly D Foote, Michael S Okun
No abstract text is available yet for this article.
June 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/27390680/supra-recommendation-treatment-of-super-refractory-status-epilepticus
#13
Devashish Dhiren Vyas, Gopal Krishna Dash
A 28-year old female was admitted with recurrent seizures following 2 days of febrile illness, after which she developed status epilepticus. Midazolam and later thiopentone infusions were started after failure of regular intravenous antiepileptics. Burst suppression was achieved at doses of 3 mg/kg/hr for midazolam and 6 mg/kg/hr of thiopentone. Adjunctive medications included methylprednisolone, intravenous immunoglobulin and acyclovir. Imaging and biochemical parameters were normal. She required 3 cycles of midazolam and 2 cycles of thiopentone for complete cessation of seizures...
June 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/27390679/a-case-of-phenytoin-induced-rhabdomyolysis-in-status-epilepticus
#14
Hyunjin Kim, Sungyang Jo, Kye Won Park, Su-Hyun Han, Sang-Ahm Lee
Phenytoin is a commonly used antiepileptic drug, especially when treating status epilepticus. Here, we present a patient who suffered from status epilepticus and developed rhabdomyolysis after being treated with phenytoin. As multiple seizures itself can induce rhabdomyolysis, it is difficult to recognize that phenytoin can be the cause of rhabdomyolysis in status epilepticus patients. Even though phenytoin is a rare cause of rhabdomyolysis, we should discern that phenytoin can be a causative drug to bring about rhabdomyolysis...
June 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/27390678/intracranial-cortical-calcifications-in-a-focal-epilepsy-patient-with-pseudohypoparathyroidism
#15
Ye Sel Kim, Jihyung Park, Yoonkyung Park, KyoungJin Hwang, Dae Lim Koo, Daeyoung Kim, Dae-Won Seo
Patients with chronic parathyroid dysfunction often have intracranial calcification in deep gray matter (GM) and subcortical white matter (WM) of their brain. Some of them are also epilepsy patients. Although cortical etiologies are main cause of epileptic seizure, cortical calcification has not been reported in these patients. We report a newly diagnosed focal epilepsy patient whose brain magnetic resonance imaging revealed intracranial calcifications in cortical as well as subcortical areas. Blood lab revealed that he had hypocalcemia due to pseudohypoparathyroidism...
June 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/27390677/an-atypical-presentation-of-subacute-encephalopathy-with-seizures-in-chronic-alcoholism-syndrome
#16
Tae-Kyoung Kim, Eui Sung Jung, Jong-Moo Park, Kyusik Kang, Woong-Woo Lee, Jung-Ju Lee
Subacute encephalopathy with seizures in chronic alcoholism syndrome is a rare clinical manifestation in patients with chronic alcohol abuse. We report the case of a patient with chronic alcoholism who presented with partial nonconvulsive status epilepticus associated with a thalamic lesion.
June 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/27390676/assessment-of-time-and-frequency-domain-parameters-of-heart-rate-variability-and-interictal-cardiac-rhythm-abnormalities-in-drug-na%C3%A3-ve-patients-with-idiopathic-generalized-epilepsy
#17
Ozden Kilinc, Altug Cincin, Aslihan Pehlivan, Ipek Midi, Alper Kepez, Kadriye Agan
BACKGROUND AND PURPOSE: Epilepsy is a disease known to occur with autonomous phenomenons. Earlier studies indicate decreased heart rate variability (HRV) during ictal and interictal periods among epilepsy patients. In this study, we aim to investigate cardiac rhythm abnormalities and HRV during interictal period between drug-naïve patients with idiopathic generalized epilepsy (IGE) and healthy control group. METHODS: Twenty-six patients with IGE and 26 healthy individuals included in the study...
June 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/27390675/the-difference-in-heart-rate-change-between-temporal-and-frontal-lobe-seizures-during-peri-ictal-period
#18
Woo Hyun Son, Woo Sub Hwang, Dae Lim Koo, Kyoung Jin Hwang, Dae Yung Kim, Ji-Hye Seo, Geon-Youb Na, Eun Yeon Joo, Seung Bong Hong, Dae-Won Seo
BACKGROUND AND PURPOSE: Heart rate (HR) change is easily seen in seizures. Tachycardia is frequently seen in temporal lobe epilepsy (TLE), rather than extra temporal lobe epilepsy (XTLE). We report the difference in the HR pattern between TLE and frontal lobe epilepsy (FLE) during peri-ictal period. METHODS: The ECG data, collected during EEG monitoring, was used. To compare the HR pattern between FLE and TLE, we investigated the baseline HR, maximum HR, seizure onset to peak HR, HR change, and the time return to baseline...
June 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/27390674/beta-lactams-antibiotic-ceftriaxone-modulates-seizures-oxidative-stress-and-connexin-43-expression-in-hippocampus-of-pentylenetetrazole-kindled-rats
#19
Abdelaziz M Hussein, Mohammed Ghalwash, Khaled Magdy, Osama A Abulseoud
BACKGROUND AND PURPOSE: This study aimed to investigate the effect of ceftriaxone on oxidative stress and gap junction protein (connexin 43, Cx-43) expression in pentylenetetrazole (PTZ) induced kindling model. METHODS: Twenty four Sprague dawely rats were divided into 3 equal groups (a) normal group: normal rats. (b) PTZ kindled group: received PTZ at the dose of 50 mg/kg via intraperitoneal injection (i.p.) every other day for 2 weeks (c) ceftriaxone treated group: received ceftriaxone at the dose 200 mg\kg/12 hrs via i...
June 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/27390673/ketogenic-diet-but-not-polyunsaturated-fatty-acid-diet-reduces-spontaneous-seizures-in-juvenile-rats-with-kainic-acid-induced-epilepsy
#20
Simone M Dustin, Carl E Stafstrom
BACKGROUND AND PURPOSE: The high-fat, low-carbohydrate ketogenic diet (KD) is effective in many cases of drug-resistant epilepsy, particularly in children. In the classic KD, fats consist primarily of long-chain saturated triglycerides. Polyunsaturated fatty acids (PUFAs), especially the n-3 type, decrease neuronal excitability and provide neuroprotection; pilot human studies have raised the possibility of using PUFAs to control seizures in patients. METHODS: To determine the relative roles of the KD and PUFAs in an animal model, we induced epilepsy in juvenile rats (P29-35) using intraperitoneal kainic acid (KA)...
June 2016: Journal of Epilepsy Research
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