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Journal of Epilepsy Research

Daniel Martinez-Ramirez, Kelly D Foote, Michael S Okun
No abstract text is available yet for this article.
June 2016: Journal of Epilepsy Research
Devashish Dhiren Vyas, Gopal Krishna Dash
A 28-year old female was admitted with recurrent seizures following 2 days of febrile illness, after which she developed status epilepticus. Midazolam and later thiopentone infusions were started after failure of regular intravenous antiepileptics. Burst suppression was achieved at doses of 3 mg/kg/hr for midazolam and 6 mg/kg/hr of thiopentone. Adjunctive medications included methylprednisolone, intravenous immunoglobulin and acyclovir. Imaging and biochemical parameters were normal. She required 3 cycles of midazolam and 2 cycles of thiopentone for complete cessation of seizures...
June 2016: Journal of Epilepsy Research
Hyunjin Kim, Sungyang Jo, Kye Won Park, Su-Hyun Han, Sang-Ahm Lee
Phenytoin is a commonly used antiepileptic drug, especially when treating status epilepticus. Here, we present a patient who suffered from status epilepticus and developed rhabdomyolysis after being treated with phenytoin. As multiple seizures itself can induce rhabdomyolysis, it is difficult to recognize that phenytoin can be the cause of rhabdomyolysis in status epilepticus patients. Even though phenytoin is a rare cause of rhabdomyolysis, we should discern that phenytoin can be a causative drug to bring about rhabdomyolysis...
June 2016: Journal of Epilepsy Research
Ye Sel Kim, Jihyung Park, Yoonkyung Park, KyoungJin Hwang, Dae Lim Koo, Daeyoung Kim, Dae-Won Seo
Patients with chronic parathyroid dysfunction often have intracranial calcification in deep gray matter (GM) and subcortical white matter (WM) of their brain. Some of them are also epilepsy patients. Although cortical etiologies are main cause of epileptic seizure, cortical calcification has not been reported in these patients. We report a newly diagnosed focal epilepsy patient whose brain magnetic resonance imaging revealed intracranial calcifications in cortical as well as subcortical areas. Blood lab revealed that he had hypocalcemia due to pseudohypoparathyroidism...
June 2016: Journal of Epilepsy Research
Tae-Kyoung Kim, Eui Sung Jung, Jong-Moo Park, Kyusik Kang, Woong-Woo Lee, Jung-Ju Lee
Subacute encephalopathy with seizures in chronic alcoholism syndrome is a rare clinical manifestation in patients with chronic alcohol abuse. We report the case of a patient with chronic alcoholism who presented with partial nonconvulsive status epilepticus associated with a thalamic lesion.
June 2016: Journal of Epilepsy Research
Ozden Kilinc, Altug Cincin, Aslihan Pehlivan, Ipek Midi, Alper Kepez, Kadriye Agan
BACKGROUND AND PURPOSE: Epilepsy is a disease known to occur with autonomous phenomenons. Earlier studies indicate decreased heart rate variability (HRV) during ictal and interictal periods among epilepsy patients. In this study, we aim to investigate cardiac rhythm abnormalities and HRV during interictal period between drug-naïve patients with idiopathic generalized epilepsy (IGE) and healthy control group. METHODS: Twenty-six patients with IGE and 26 healthy individuals included in the study...
June 2016: Journal of Epilepsy Research
Woo Hyun Son, Woo Sub Hwang, Dae Lim Koo, Kyoung Jin Hwang, Dae Yung Kim, Ji-Hye Seo, Geon-Youb Na, Eun Yeon Joo, Seung Bong Hong, Dae-Won Seo
BACKGROUND AND PURPOSE: Heart rate (HR) change is easily seen in seizures. Tachycardia is frequently seen in temporal lobe epilepsy (TLE), rather than extra temporal lobe epilepsy (XTLE). We report the difference in the HR pattern between TLE and frontal lobe epilepsy (FLE) during peri-ictal period. METHODS: The ECG data, collected during EEG monitoring, was used. To compare the HR pattern between FLE and TLE, we investigated the baseline HR, maximum HR, seizure onset to peak HR, HR change, and the time return to baseline...
June 2016: Journal of Epilepsy Research
Abdelaziz M Hussein, Mohammed Ghalwash, Khaled Magdy, Osama A Abulseoud
BACKGROUND AND PURPOSE: This study aimed to investigate the effect of ceftriaxone on oxidative stress and gap junction protein (connexin 43, Cx-43) expression in pentylenetetrazole (PTZ) induced kindling model. METHODS: Twenty four Sprague dawely rats were divided into 3 equal groups (a) normal group: normal rats. (b) PTZ kindled group: received PTZ at the dose of 50 mg/kg via intraperitoneal injection (i.p.) every other day for 2 weeks (c) ceftriaxone treated group: received ceftriaxone at the dose 200 mg\kg/12 hrs via i...
June 2016: Journal of Epilepsy Research
Simone M Dustin, Carl E Stafstrom
BACKGROUND AND PURPOSE: The high-fat, low-carbohydrate ketogenic diet (KD) is effective in many cases of drug-resistant epilepsy, particularly in children. In the classic KD, fats consist primarily of long-chain saturated triglycerides. Polyunsaturated fatty acids (PUFAs), especially the n-3 type, decrease neuronal excitability and provide neuroprotection; pilot human studies have raised the possibility of using PUFAs to control seizures in patients. METHODS: To determine the relative roles of the KD and PUFAs in an animal model, we induced epilepsy in juvenile rats (P29-35) using intraperitoneal kainic acid (KA)...
June 2016: Journal of Epilepsy Research
Hyun-Soon Jang, Sook Young Roh, Eun Hye Jeong, Byung-Su Kim, Mun Kyung Sunwoo
Although ginkgo is commonly used as an alternative treatment for memory loss, Alzheimer's dementia and peripheral circulatory disturbances, it is also known to cause neuronal symptoms due to ginkgotoxin (4'-methoxypyridoxine or B6 antivitamin). We experienced a case of a 51-year-old female patient with generalized tonic clonic seizure and postictal confusion after eating large amounts of ginkgo nuts. Blood vitamin B6 level was decreased. After conservative treatment and pyridoxine medication, her mental symptoms were resolved completely and no seizures recurred...
December 2015: Journal of Epilepsy Research
Seong-Hae Jeong, Yong Soo Kim, Ju-Hoen Lee, Hyunjin Jo, Ae Young Lee, Jae-Moon Kim
Head impulse test (HIT) is helpful to understanding high-frequency vestibulo-ocular reflex in patients with dizziness and imbalance. There are some reports on abnormal HITs in cerebellar disorder. To our knowledge, there was no report of transient bilateral positive head impulse related to antiepileptic drugs. A 65-year-old woman developed dizziness and imbalance after treatment with pregabalin for pain control of radiation cystitis. Neurological examination exhibited positive bilateral HIT results, in addition to ataxia and gaze-evoked rebound nystagmus...
December 2015: Journal of Epilepsy Research
Jin-Gyu Choi, Si-Hoon Lee, Young-Min Shon, Byung-Chul Son
The long-term (5-years) antiepileptic effect of deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) against refractory epilepsy has been reported. However, experience with ANT DBS for epilepsy is limited, and so hardware complications and technical problems related to ANT DBS are unclear. We report the case of a 57-year-old male who underwent re-implantation of a DBS lead in the left ANT because of lead migration into the third ventricle detected 8 years after the first DBS, and which was caused by the significant enlargement of the lateral and third ventricles...
December 2015: Journal of Epilepsy Research
Hye Jin Lee, Jeong Min Son, Jihee Mun, Dong Wook Kim
BACKGROUND AND PURPOSE: Zonisamide (ZNS) is one of new antiepileptic drug, which is known to inhibit seizure through multiple mechanisms of action. In Korea, ZNS was approved as an antiepileptic drug in 1992 and has been used for epilepsy patients with partial and generalized seizures. The objective of this study was to investigate the efficacy and tolerability of ZNS in patients with epilepsy and to identify the incidence of adverse events in real clinical setting. METHODS: This study was carried out in patients who received ZNS for epilepsy...
December 2015: Journal of Epilepsy Research
Pairoj Boonluksiri, Anannit Visuthibhan, Kamornwan Katanyuwong
BACKGROUND AND PURPOSE: Clinical prediction rules (CPR) are clinical decision-making tools containing variables such as history, physical examination, diagnostic tests by developing scoring model from potential risk factors. This study is to establish clinical prediction scoring of drug-resistant epilepsy (DRE) in children using clinical manifestationa and only basic electroencephalography (EEG). METHODS: Retrospective cohort study was conducted. A total of 308 children with diagnosed epilepsy were recruited...
December 2015: Journal of Epilepsy Research
Jung Hwa Lee, Eun Yeon Joo, Dae Won Seo, Seung Bong Hong
BACKGROUND AND PURPOSE: Numerous transcranial magnetic stimulation (TMS) studies have defined the characteristic features of TMS in epilepsy. TME parameters were expected to classify the epilepsy syndrome or drug responses. However, the results such as cortical silent periods (CSP) are variable according to conditions of patients. Here, we investigate whether specific TMS parameters have localizing or lateralizing values in drug-naïve epilepsy patients. METHODS: We recruited 148 consecutive untreated patients with epilepsy (idiopathic generalized epilepsy (IGE) 38, focal epilepsy (FE) 110, mean age 31...
December 2015: Journal of Epilepsy Research
Yoon Kyoung Park, So-Hee Eun, Baik-Lin Eun, Jung Hye Byeon
BACKGROUND AND PURPOSE: Benign childhood epilepsy with centrotemporal spikes (BCECTS) is the most common pediatric focal epilepsy syndrome and typically has positive clinical outcomes. However, a few patients experience recurrent seizures, and therefore, require treatment with antiepileptic drugs (AEDs). This study aimed to identify risk factors associated with poor response to initial AED therapy in BCECTS patients. METHODS: We retrospectively reviewed the files of 57 patients who were diagnosed with BCECTS between January 2008 and September 2013...
December 2015: Journal of Epilepsy Research
Sandhya Mangalore, Rose Dawn Bharath, Neeraj Upadhyay, Ganne Chaitanya, Rajanikanth Panda, A K Gupta, P Satish Chandra, Malla Bhaskar Rao, Anita Mahadevan
BACKGROUND AND PURPOSE: The main challenge in assessing patients with epilepsy is the localization of neuronal networks involved in seizure generation and the lateralization of seizure onset. Electro encephalogram-functional magnetic resonance imaging (EEG-fMRI) is a noninvasive multimodal imaging technique for epilepsies where the data is acquired based on the interictal epileptiform discharges (IED). Since this is a new technique, the specificity for lateralizing epileptic focus is yet to be established...
December 2015: Journal of Epilepsy Research
L K Friedman, A M Slomko, J P Wongvravit, Z Naseer, S Hu, W Y Wan, S S Ali
BACKGROUND AND PURPOSE: The efficacy of retigabine (RGB), a positive allosteric modulator of K+ channels indicated for adjunct treatment of partial seizures, was studied in two adult models of kainic acid (KA)-induced status epilepticus to determine it's toleratbility. METHODS: Retigabine was administered systemiclly at high (5 mg/kg) and low (1-2 mg/kg) doses either 30 min prior to or 2 hr after KA-induced status epilepticus. High (1 µg/µL) and low (0.25 µg/µL) concentrations of RGB were also delivered by intrahippocampal microinjection in the presence of KA...
December 2015: Journal of Epilepsy Research
Parveen Bansal, Ramandeep Kaur, Vikas Gupta, Sanjiv Kumar, RamanPreet Kaur
Epilepsy is a neuropsychiatric disorder associated with religiosity and spirituality. Nasal drug delivery systems are the best for diseases related to brain. In older times RishiMuni, ancient scholars and physicians used to recommend Hawan for mental peace and well being. Gayatri Mantra also tells that sughandhim (aroma, fragrance) puushtivardhanam (gives rise to good health). Om triambkum yajamahe, sughandhim puushtivardhanam, urvarukmev vandhanaat, mrityu mokshay mamritaat! Hawan is a scientific experiment in which special herbs (Hawan Samagri) are offered in the fire of medicinal woods ignited in a specially designed fire pit called agnikuñda...
December 2015: Journal of Epilepsy Research
Jiyoung Kim, Seung Ha Park, Yu Ri Jung, Soon Won Park, Dae Soo Jung
Anti N-methyl-D-aspartate (NMDA) receptor encephalitis is one of the most common types of autoimmune synaptic encephalitis. Anti-NMDA receptor encephalitis commonly occurs in young women with ovarian teratoma. It has variable clinical manifestations and treatment responses. Sometimes it is misdiagnosed as a psychiatric disorder or viral encephalitis. To the best of our knowledge, anti-NMDA receptor encephalitis is a rare condition in pregnant women. We report a case of anti-NMDA receptor encephalitis in a pregnant woman who presented with abnormal behavior, epileptic seizure, and hypoventilation...
June 2015: Journal of Epilepsy Research
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