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Endocrinology and Metabolism

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https://www.readbyqxmd.com/read/28956371/letter-utility-of-the-visceral-adiposity-index-and-hypertriglyceridemic-waist-phenotype-for-predicting-incident-hypertension-endocrinol-metab-2017-32-221-9-mohsen-janghorbani-et-al
#1
LETTER
https://www.readbyqxmd.com/read/28956370/effects-of-lobeglitazone-a-new-thiazolidinedione-on-osteoblastogenesis-and-bone-mineral-density-in-mice
#2
Kyoung Min Kim, Hyun Jin Jin, Seo Yeon Lee, Hyo Jin Maeng, Gha Young Lee, Tae Jung Oh, Sung Hee Choi, Hak Chul Jang, Soo Lim
BACKGROUND: Bone strength is impaired in patients with type 2 diabetes mellitus despite an increase in bone mineral density (BMD). Thiazolidinedione (TZD), a peroxisome proliferator activated receptor γ agonist, promotes adipogenesis, and suppresses osteoblastogenesis. Therefore, its use is associated with an increased risk of fracture. The aim of this study was to examine the in vitro and in vivo effects of lobeglitazone, a new TZD, on bone. METHODS: MC3T3E1 and C3H10T1/2 cells were cultured in osteogenic medium and exposed to lobeglitazone (0...
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28956369/the-role-of-circulating-slit2-the-one-of-the-newly-batokines-in-human-diabetes-mellitus
#3
Yea Eun Kang, Sorim Choung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
BACKGROUND: Slit2 is a new secreted protein from adipose tissue that improves glucose hemostasis in mice; however, there is no study about the serum levels and precise role of Slit2 in human. The aim of this study is to explore the serum level of Slit2 in human, and to identify the role of Slit2 in diabetes mellitus (DM). METHODS: The participants of this study consist of 38 subjects with newly diagnosed DM, and 75 healthy subjects as a control group. Serum Slit2 levels were measured using an enzyme-linked immunosorbent assay...
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28956368/a-novel-index-using-soluble-cd36-is-associated-with-the-prevalence-of-type-2-diabetes-mellitus-comparison-study-with-triglyceride-glucose-index
#4
Ho Jin Kim, Jun Sung Moon, Il Rae Park, Joong Hee Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
BACKGROUND: Plasma soluble cluster determinant 36 (sCD36) level is closely related with insulin resistance and atherosclerosis, but little is known whether it could be a surrogate for estimating risk of developing diabetes or not. To address this, we evaluated association between sCD36 index, the product of sCD36 and fasting plasma glucose (FPG), and the prevalence of type 2 diabetes mellitus (T2DM), and then compared with triglyceride-glucose (TyG) index which has been suggested simple index for insulin resistance...
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28956367/excessive-iodine-status-among-school-age-children-in-korea-a-first-report
#5
Young Sik Choi, Soyoung Ock, Sukyoung Kwon, Sang Bong Jung, Kwang Hyuk Seok, Young Jin Kim, Bu Kyung Kim, Jee Yeong Jeong
BACKGROUND: Korea is considered an iodine sufficient country, and several studies have been conducted regarding iodine status in healthy Korean adults, pregnant women, and preschool children. However, data on iodine status in Korean school-age children are lacking. Therefore, the iodine nutrition status of Korean school-age children was investigated by measuring urine iodine concentration (UIC). METHODS: This cross-sectional study conducted between April and September 2016 comprised 373 school-age children...
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28956366/leu72met-and-other-intronic-polymorphisms-in-the-ghrl-and-ghsr-genes-are-not-associated-with-type-2-diabetes-mellitus-insulin-resistance-or-serum-ghrelin-levels-in-a-saudi-population
#6
Faris Elbahi Joatar, Ali Ahmed Al Qarni, Muhalab E Ali, Abdulaziz Al Masaud, Abdirashid M Shire, Nagalla Das, Khalid Gumaa, Hayder A Giha
BACKGROUND: Ghrelin (GHRL), a gastric peptide encoded by the GHRL gene, is known to be involved in energy homeostasis via its G protein receptor, encoded by the growth hormone secretagogue receptor (GHSR) gene. Some studies have shown associations between plasma GHRL levels and GHRL single-nucleotide polymorphisms (SNPs), namely the Leu72Met polymorphism (rs696217 TG), with type 2 diabetes mellitus (T2DM) and insulin resistance (IR), while others have not. The controversies in these associations raise the issue of 'which SNPs in which populations...
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28956365/the-eosinophil-count-tends-to-be-negatively-associated-with-levels-of-serum-glucose-in-patients-with-adrenal-cushing-syndrome
#7
Younghak Lee, Hyon Seung Yi, Hae Ri Kim, Kyong Hye Joung, Yea Eun Kang, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Bon Jeong Ku, Minho Shong
BACKGROUND: Cushing syndrome is characterized by glucose intolerance, cardiovascular disease, and an enhanced systemic inflammatory response caused by chronic exposure to excess cortisol. Eosinopenia is frequently observed in patients with adrenal Cushing syndrome, but the relationship between the eosinophil count in peripheral blood and indicators of glucose level in patients with adrenal Cushing syndrome has not been determined. METHODS: A retrospective study was undertaken of the clinical and laboratory findings of 40 patients diagnosed with adrenal Cushing syndrome at Chungnam National University Hospital from January 2006 to December 2016...
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28956364/endocrinology-and-metabolism-is-indexed-in-the-emerging-sources-citation-index
#8
EDITORIAL
Won Young Lee
No abstract text is available yet for this article.
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28956363/calcium-and-cardiovascular-disease
#9
REVIEW
Ian R Reid, Sarah M Birstow, Mark J Bolland
Circulating calcium is a risk factor for vascular disease, a conclusion arising from prospective studies involving hundreds of thousands of participants and extending over periods of up to 30 years. These associations may be partially mediated by other cardiovascular risk factors such as circulating lipid levels, blood pressure, and body mass index, but there appears to be a residual independent effect of serum calcium. Polymorphisms of the calcium-sensing receptor associated with small elevations of serum calcium are also associated with cardiovascular disease, suggesting that calcium plays a causative role...
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28956362/ctnnb1-mutation-in-aldosterone-producing-adenoma
#10
REVIEW
Jian Jhong Wang, Kang Yung Peng, Vin Cent Wu, Fen Yu Tseng, Kwan Dun Wu
Discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas (APAs) with distinct clinical presentations and pathological features. Catenin β1 (CTNNB1) mutation in APAs has been recently described and discussed in the literature. However, significant knowledge gaps still remain regarding the prevalence, clinical characteristics, pathophysiology, and outcomes in APA patients harboring CTNNB1 mutations. Aberrant activation of the Wnt/β-catenin signaling pathway will further modulate tumorigenesis...
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28956361/epigenetic-modifications-novel-therapeutic-approach-for-thyroid-cancer
#11
REVIEW
Xuguang Zhu, Sheue Yann Cheng
The incidence of thyroid cancer is growing the fastest among all cancers in the United States, especially in women. The number of patients with thyroid neoplasm is part of an even larger number of patients who often need to undergo an operation to exclude a cancer diagnosis. While differentiated thyroid cancer (papillary thyroid cancer and follicular thyroid cancer) accounts for most cases of thyroid cancer and has a relatively good prognosis, effective treatments for patients with de-differentiated and anaplastic thyroid cancer are still gravely needed...
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28956360/effects-of-incretin-based-therapies-on-diabetic-microvascular-complications
#12
REVIEW
Yu Mi Kang, Chang Hee Jung
The morbidity and mortality associated with diabetic complications impose a huge socioeconomic burden worldwide. Therefore, the ultimate goal of managing diabetes mellitus (DM) is to lower the risk of macrovascular complications and highly morbid microvascular complications such as diabetic nephropathy (DN) and diabetic retinopathy (DR). Potential benefits of incretin-based therapies such as glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors on the diabetic macrovascular complications have been recently suggested, owing to their pleiotropic effects on multiple organ systems...
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28956359/metabolic-surgery-in-korea-what-to-consider-before-surgery
#13
REVIEW
Mi Kyung Kim, Yoonseok Heo
Obesity is increasing globally and represents a significant global health problem because it predisposes towards various diseases, such as type 2 diabetes mellitus, cardiovascular disease, degenerative joint disease, and certain types of cancer. Numerous studies have shown that bariatric surgery reduces body mass and ameliorates obesity-related complications, such as hypertension and hyperglycemia, suggesting that surgery is the most effective therapeutic option for severely obese and obese diabetic patients...
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28685521/erratum-correction-of-figure-clinical-implications-of-various-criteria-for-the-biochemical-diagnosis-of-insulinoma
#14
Chang Ho Ahn, Lee Kyung Kim, Jie Eun Lee, Chan Hyeon Jung, Se Hee Min, Kyong Soo Park, Seong Yeon Kim, Young Min Cho
This corrects the article on p. 498 in vol. 29, PMID: 25325272.
June 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28685520/response-thyroid-stimulating-hormone-reference-range-and-prevalence-of-thyroid-dysfunction-in-the-korean-population-korea-national-health-and-nutrition-examination-survey-2013-to-2015-endocrinol-metab-2017-32-106-14-won-gu-kim-et-al
#15
LETTER
https://www.readbyqxmd.com/read/28685519/letter-thyroid-stimulating-hormone-reference-range-and-prevalence-of-thyroid-dysfunction-in-the-korean-population-korea-national-health-and-nutrition-examination-survey-2013-to-2015-endocrinol-metab-2017-32-106-14-won-gu-kim-et-al
#16
LETTER
https://www.readbyqxmd.com/read/28685518/poorly-differentiated-thyroid-carcinoma-10-year-experience-in-a-southeast-asian-population
#17
Marc Gregory Yu, Jonathan Rivera, Cecilia Jimeno
BACKGROUND: No previous studies have been published on poorly differentiated thyroid carcinoma (PDTC) in Southeast Asia. METHODS: We included all adult PDTC patients diagnosed using the Turin criteria at the Philippine General Hospital from 2006 to 2015. The data collected included demographics, clinical presentation, histopathology, treatment, and outcomes. Tests of association were employed to compare these data with foreign studies on PDTC, as well as with local studies on well differentiated thyroid carcinoma (WDTC) and anaplastic thyroid carcinoma (ATC)...
June 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28685517/free-thyroxine-anti-thyroid-stimulating-hormone-receptor-antibody-titers-and-absence-of-goiter-were-associated-with-responsiveness-to-methimazole-in-patients-with-new-onset-graves-disease
#18
Hoon Sung Choi, Won Sang Yoo
BACKGROUND: Anti-thyroid drug therapy is considered a treatment of choice for Graves' disease; however, treatment response varies among individuals. Although several studies have reported risk factors for relapse after initial treatment, few have assessed responsiveness during the early treatment period. Our study aimed to identify the clinical characteristics for responsiveness to methimazole. METHODS: We included 99 patients diagnosed with Graves' disease for the first time...
June 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28685516/comparison-between-atorvastatin-and-rosuvastatin-in-renal-function-decline-among-patients-with-diabetes
#19
Eugene Han, Gyuri Kim, Ji Yeon Lee, Yong Ho Lee, Beom Seok Kim, Byung Wan Lee, Bong Soo Cha, Eun Seok Kang
BACKGROUND: Although the beneficial effects of statin treatment in dyslipidemia and atherosclerosis have been well studied, there is limited information regarding the renal effects of statins in diabetic nephropathy. We aimed to investigate whether, and which, statins affected renal function in Asian patients with diabetes. METHODS: We enrolled 484 patients with diabetes who received statin treatment for more than 12 months. We included patients treated with moderate-intensity dose statin treatment (atorvastatin 10 to 20 mg/day or rosuvastatin 5 to 10 mg/day)...
June 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28685515/predetermined-anti-diabetic-drug-regimen-adjustments-during-ramadan-fasting-an-observational-study-of-safety
#20
Abdallah M Beano, Mohammad A Zmaili, Zaid H Gheith, Ahmad M Naser, Munther S Momani, Al Motassem F Yousef, Ayman A Zayed
BACKGROUND: Many Muslim type 2 diabetes mellitus (T2DM) patients choose to fast the month of Ramadan despite the possible adverse health effects brought about by the change in dietary habits, among other things. Clinical data regarding the safety of multi-drug regimens during fasting are particularly scarce. The aim of the study was to evaluate the safety of a drug protocol devised by the authors to accommodate Ramadan's dietary changes, involving dose adjustments of four anti-diabetic drug regimens in T2DM patients fasting Ramadan...
June 2017: Endocrinology and Metabolism
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