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Endocrinology and Metabolism

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https://www.readbyqxmd.com/read/29766683/star-shaped-intense-uptake-of-%C3%A2-%C3%A2-%C3%A2-i-on-whole-body-scans-can-reflect-good-therapeutic-effects-of-low-dose-radioactive-iodine-treatment-of-1-1-gbq
#1
Sung Hye Kong, Jung Ah Lim, Young Shin Song, Shinje Moon, Ye An Kim, Min Joo Kim, Sun Wook Cho, Jae Hoon Moon, Ka Hee Yi, Do Joon Park, Bo Youn Cho, Young Joo Park
BACKGROUND: After initial radioactive iodine (RAI) treatment in differentiated thyroid cancer patients, we sometimes observe a star-shaped region of intense uptake of ¹³¹I on whole body scans (WBSs), called a 'star artifact.' We evaluated the clinical implications of star artifacts on the success rate of remnant ablation and long-term prognosis. METHODS: Total 636 patients who received ¹³¹I dose of 1.1 GBq for the initial RAI therapy and who did not show distant metastasis at the time of diagnosis were retrospectively evaluated...
May 4, 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29766682/distinct-ultradian-rhythms-in-plasma-clusterin-concentrations-in-lean-and-obese-korean-subjects
#2
Jong Han Choi, Eunheui Jeong, Byung Soo Youn, Min Seon Kim
BACKGROUND: Blood levels of many hormones show rhythmic fluctuations with variable duration of cycles. Clusterin/apolipoprotein J is a glycoprotein which is highly expressed in the plasma and has modulatory roles in immune and inflammatory reactions, neurobiology, lipid metabolism, and leptin signaling. In this study, we examined the diurnal fluctuations of plasma clusterin concentrations in lean and obese young men. METHODS: For the study, 14 subjects (five lean and five obese men; two lean and two obese women) were admitted to the research ward and blood samples were drawn every 30 minutes during light-on period (6:00 AM to 10:00 PM) and every hour during light-off period...
May 4, 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29766681/evaluation-of-thyroid-hormone-levels-and-urinary-iodine-concentrations-in-koreans-based-on-the-data-from-korea-national-health-and-nutrition-examination-survey-vi-2013-to-2015
#3
REVIEW
Jae Hoon Chung
No nationwide data have been published about thyroid hormone levels and urinary iodine concentrations (UICs) in Korea. The Korea Centers for Disease Control and Prevention and the Korean Thyroid Association established a project to evaluate the nationwide thyroid hormone profile and UICs in healthy Koreans as part of the Korea National Health and Nutrition Examination Survey (KNHANES) VI (2013 to 2015), a nationwide, cross-sectional survey of the Korean population that enrolled 7,061 individuals who were weighted to represent the entire Korean population...
May 4, 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29766680/c-arm-computed-tomography-assisted-adrenal-venous-sampling-improved-right-adrenal-vein-cannulation-and-sampling-quality-in-primary-aldosteronism
#4
Chung Hyun Park, Namki Hong, Kichang Han, Sang Wook Kang, Cho Rok Lee, Sungha Park, Yumie Rhee
BACKGROUND: Adrenal venous sampling (AVS) is a gold standard for subtype classification of primary aldosteronism (PA). However, this procedure has a high failure rate because of the anatomical difficulties in accessing the right adrenal vein. We investigated whether C-arm computed tomography-assisted AVS (C-AVS) could improve the success rate of adrenal sampling. METHODS: A total of 156 patients, diagnosed with PA who underwent AVS from May 2004 through April 2017, were included...
May 4, 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29766679/comparison-of-the-effects-of-ezetimibe-statin-combination-therapy-on-major-adverse-cardiovascular-events-in-patients-with-and-without-diabetes-a-meta-analysis
#5
Namki Hong, Yong Ho Lee, Kenichi Tsujita, Jorge A Gonzalez, Christopher M Kramer, Tomas Kovarnik, George N Kouvelos, Hiromichi Suzuki, Kyungdo Han, Chan Joo Lee, Sung Ha Park, Byung Wan Lee, Bong Soo Cha, Eun Seok Kang
BACKGROUND: Ezetimibe-statin combination therapy has been found to reduce low density lipoprotein cholesterol levels and the risk of major adverse cardiovascular events (MACEs) in large trials. We sought to examine the differential effect of ezetimibe on MACEs when added to statins according to the presence of diabetes. METHODS: Randomized clinical trials with a sample size of at least 50 participants and at least 24 weeks of follow-up that compared ezetimibe-statin combination therapy with a statin- or placebo-controlled arm and reported at least one MACE, stratified by diabetes status, were included in the meta-analysis and meta-regression...
May 4, 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29766678/association-between-bone-mineral-density-and-albuminuria-cross-sectional-analysis-of-data-from-the-2011-korea-national-health-and-nutrition-examination-survey-v-2
#6
Tae Yang Yu, Ha Young Kim, Jeong Mi Lee, Dae Ho Lee, Chung Gu Cho
BACKGROUND: Albuminuria is known to be independently associated with progression of renal and cardiovascular disease. However, little is known regarding the exact relationship between albuminuria and bone mineral density (BMD). The aim of this population-based study conducted in Korea was to identify the association between albuminuria and BMD. METHODS: We performed a cross-sectional analysis of data from the Korea National Health and Nutrition Examination Survey (KNHANES V-2) 2011...
May 4, 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589396/erratum-addendum-of-informed-consent-statements
#7
(no author information available yet)
This corrects the article on p. 110 in vol. 30, PMID: 25491781 This corrects the article on p. 395 in vol. 30, PMID: 25491785.
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589395/active-surveillance-of-papillary-thyroid-microcarcinoma-a-mini-review-from-korea-endocrinol-metab-2017-32-399-406-tae-yong-kim-et-al
#8
LETTER
Hui Sun, Gianlorenzo Dionigi
No abstract text is available yet for this article.
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589394/combined-effects-of-baicalein-and-docetaxel-on-apoptosis-in-8505c-anaplastic-thyroid-cancer-cells-via-downregulation-of-the-erk-and-akt-mtor-pathways
#9
Chan Ho Park, Se Eun Han, Il Seong Nam-Goong, Young Il Kim, Eun Sook Kim
BACKGROUND: Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies. Docetaxel, a microtubule stabilizer, is a common chemotherapeutic agent used to treat various metastatic cancers. However, prolonged use results in various side effects and drug resistance. Flavonoids, such as baicalein, are accepted chemotherapeutic and dietary chemopreventive agents with many advantages, such as greater accessibility, affordability, and lower toxicity, compared with traditional chemotherapy agents...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589393/a-comparison-of-ultrasound-guided-fine-needle-aspiration-versus-core-needle-biopsy-for-thyroid-nodules-pain-tolerability-and-complications
#10
Eun Ji Jeong, Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Jae Kyun Kim, Jeong Hyun Lee
BACKGROUND: To compare pain, tolerability, and complications associated with fine needle aspiration (FNA) versus core needle biopsy (CNB). METHODS: FNAs were performed using 23-gauge needles and CNBs were performed using 18-gauge double-action spring-activated needles in 100 patients for each procedure. Patients were asked to record a pain score using a 10-cm visual analog scale and procedure tolerability. Complications and number of biopsies were recorded. RESULTS: The median pain scores were similar for the FNA and CNB approaches during and 20 minutes after the biopsy procedures (3...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589392/pioglitazone-attenuates-palmitate-induced-inflammation-and-endoplasmic-reticulum-stress-in-pancreatic-%C3%AE-cells
#11
Seok Woo Hong, Jinmi Lee, Jung Hwan Cho, Hyemi Kwon, Se Eun Park, Eun Jung Rhee, Cheol Young Park, Ki Won Oh, Sung Woo Park, Won Young Lee
BACKGROUND: The nuclear receptor peroxisome proliferator-activator gamma (PPARγ) is a useful therapeutic target for obesity and diabetes, but its role in protecting β-cell function and viability is unclear. METHODS: To identify the potential functions of PPARγ in β-cells, we treated mouse insulinoma 6 (MIN6) cells with the PPARγ agonist pioglitazone in conditions of lipotoxicity, endoplasmic reticulum (ER) stress, and inflammation. RESULTS: Palmitate-treated cells incubated with pioglitazone exhibited significant improvements in glucose-stimulated insulin secretion and the repression of apoptosis, as shown by decreased caspase-3 cleavage and poly (adenosine diphosphate [ADP]-ribose) polymerase activity...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589391/effects-of-serum-albumin-calcium-levels-cancer-stage-and-performance-status-on-weight-loss-in-parathyroid-hormone-related-peptide-positive-or-negative-patients-with-cancer
#12
Ji Yeon Lee, Namki Hong, Hye Ryun Kim, Byung Wan Lee, Eun Seok Kang, Bong Soo Cha, Yong Ho Lee
BACKGROUND: A recent animal study showed that parathyroid hormone-related peptide (PTHrP) is associated with cancer cachexia by promoting adipose tissue browning, and we previously demonstrated that PTHrP predicts weight loss (WL) in patients with cancer. In this study, we investigated whether prediction of WL by PTHrP is influenced by clinical factors such as serum albumin, corrected calcium levels, cancer stage, and performance status (PS). METHODS: A cohort of 219 patients with cancer whose PTHrP level was measured was enrolled and followed for body weight (BW) changes...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589390/high-brachial-ankle-pulse-wave-velocity-as-a-marker-for-predicting-coronary-artery-stenosis-in-patients-with-type-2-diabetes
#13
Bo Hyun Kim, Jae Sik Jang, Yong Seop Kwon, June Hyung Kim, In Joo Kim, Chang Won Lee
BACKGROUND: We evaluated the ability of brachial ankle pulse wave velocity (baPWV) to predict coronary artery stenosis (CAS) in patients with type 2 diabetes, and compared the predictive power of baPWV to that of well-known cardiovascular disease (CVD) risk calculators. METHODS: The study group included 83 consecutive patients over 30 years old with type 2 diabetes who complained of vague chest discomfort. An automatic pulse waveform analyzer was used to measure baPWV...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589389/validity-and-reliability-of-the-korean-version-of-the-hyperthyroidism-symptom-scale
#14
Jie Eun Lee, Dong Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Sung Hee Choi, Soo Lim, Young Joo Park, Do Joon Park, Hak Chul Jang, Jae Hoon Moon
BACKGROUND: Thyrotoxicosis is a common disease resulting from an excess of thyroid hormones, which affects many organ systems. The clinical symptoms and signs are relatively nonspecific and can vary depending on age, sex, comorbidities, and the duration and cause of the disease. Several symptom rating scales have been developed in an attempt to assess these symptoms objectively and have been applied to diagnosis or to evaluation of the response to treatment. The aim of this study was to assess the reliability and validity of the Korean version of the hyperthyroidism symptom scale (K-HSS)...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589388/the-significance-of-having-an-excellent-patient-s-comfort-with-thyroid-core-needle-biopsy
#15
EDITORIAL
Pierpaolo Trimboli, Luca Giovanella
No abstract text is available yet for this article.
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589387/evidence-of-the-possible-harm-of-endocrine-disrupting-chemicals-in-humans-ongoing-debates-and-key-issues
#16
REVIEW
Duk Hee Lee
Evidence has emerged that endocrine-disrupting chemicals (EDCs) can produce adverse effects, even at low doses that are assumed safe. However, systemic reviews and meta-analyses focusing on human studies, especially of EDCs with short half-lives, have demonstrated inconsistent results. Epidemiological studies have insuperable methodological limitations, including the unpredictable net effects of mixtures, non-monotonic dose-response relationships, the non-existence of unexposed groups, and the low reliability of exposure assessment...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589386/association-of-adipokines-with-development-and-progression-of-nonalcoholic-fatty-liver-disease
#17
REVIEW
Chrysoula Boutari, Nikolaos Perakakis, Christos Socrates Mantzoros
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting 30% of the general population and 40% to 70% of obese individuals. Adipose tissue plays a crucial role in its pathogenesis, as it produces and secretes pro- and anti-inflammatory cytokines called adipokines. Adiponectin and leptin have well-determined actions in terms of NAFLD pathophysiology. Adiponectin deficiency is associated with a pro-inflammatory condition, as it is observed in obesity and other metabolic disorders. On the other hand, increased leptin levels, above the normal levels, act as a pro-inflammatory stimulus...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589385/evolution-of-diabetes-care-in-hong-kong-from-the-hong-kong-diabetes-register-to-jade-pearl-program-to-ramp-and-pep-program
#18
REVIEW
Ivy H Y Ng, Kitty K T Cheung, Tiffany T L Yau, Elaine Chow, Risa Ozaki, Juliana C N Chan
The rapid increase in diabetes prevalence globally has contributed to large increases in health care expenditure on diabetic complications, posing a major health burden to countries worldwide. Asians are commonly observed to have poorer β-cell function and greater insulin resistance compared to the Caucasian population, which is attributed by their lower lean body mass and central obesity. This "double phenotype" as well as the rising prevalence of young onset diabetes in Asia has placed Asians with diabetes at high risk of cardiovascular and renal complications, with cancer emerging as an important cause of morbidity and mortality...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589384/pathophysiology-of-type-2-diabetes-in-koreans
#19
REVIEW
Soo Heon Kwak, Kyong Soo Park
The pathophysiology of type 2 diabetes is characterized by variable degrees of insulin resistance and impaired insulin secretion. Both genetic and environmental factors serve as etiologic factors. Recent genetic studies have identified at least 83 variants associated with diabetes. A significant number of these loci are thought to be involved in insulin secretion, either through β-cell development or β-cell dysfunction. Environmental factors have changed rapidly during the past half century, and the increased prevalence of obesity and diabetes can be attributed to these changes...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29589383/bone-health-in-adrenal-disorders
#20
REVIEW
Beom Jun Kim, Seung Hun Lee, Jung Min Koh
Secondary osteoporosis resulting from specific clinical disorders may be potentially reversible, and thus continuous efforts to find and adequately treat the secondary causes of skeletal fragility are critical to ameliorate fracture risk and to avoid unnecessary treatment with anti-osteoporotic drugs. Among the hyperfunctional adrenal masses, Cushing's syndrome, pheochromocytoma, and primary aldosteronism are receiving particularly great attention due to their high morbidity and mortality mainly by increasing cardiovascular risk...
March 2018: Endocrinology and Metabolism
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