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Endocrinology and Metabolism

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https://www.readbyqxmd.com/read/29947186/the-association-between-persistent-hypertriglyceridemia-and-the-risk-of-diabetes-development-the-kangbuk-samsung-health-study-endocrinol-metab-2018-33-55-61-yu-hyun-kwon-et-al
#1
LETTER
https://www.readbyqxmd.com/read/29947185/influence-of-vitamin-d-deficiency-on-progression-of-experimental-otitis-media-in-rats
#2
Hee Bok Kim, So Hyun Lim, Chang Gun Cho, Han Seok Choi
BACKGROUND: Vitamin D plays an important role in the immune response against infection. The purpose of the present study was to investigate the influence of vitamin D deficiency on the progression of otitis media (OM) using an experimental rat model. METHODS: Four-week-old male Sprague-Dawley rats (n=72) were divided into two groups based on their diet: a control diet group (n=36) and a vitamin D-deficient diet group (n=36). After 8 weeks of diet, experimental OM was induced by inoculation of non-typeable Haemophilus influenzae in the middle ear cavity...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29947184/prognosis-of-differentiated-thyroid-carcinoma-with-initial-distant-metastasis-a-multicenter-study-in-korea
#3
Hosu Kim, Hye In Kim, Sun Wook Kim, Jaehoon Jung, Min Ji Jeon, Won Gu Kim, Tae Yong Kim, Hee Kyung Kim, Ho Cheol Kang, Ji Min Han, Yoon Young Cho, Tae Hyuk Kim, Jae Hoon Chung
BACKGROUND: Most patients with differentiated thyroid cancer (DTC) have a favorable prognosis. However, patients with DTC and initial distant metastasis have not been commonly found, and their clinical characteristics have seldom been reported. In this study, we analyzed the clinical features and prognosis of patients with DTC and initial distant metastasis in Korea. METHODS: We retrospectively reviewed the clinical data of 242 patients with DTC and initial distant metastasis treated from 1994 to 2013, collected from five tertiary hospitals in Korea...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29947183/study-protocol-of-multicenter-prospective-cohort-study-of-active-surveillance-on-papillary-thyroid-microcarcinoma-maestro
#4
Jae Hoon Moon, Ji Hoon Kim, Eun Kyung Lee, Kyu Eun Lee, Sung Hye Kong, Yeo Koon Kim, Woo Jin Jung, Chang Yoon Lee, Roh Eul Yoo, Yul Hwangbo, Young Shin Song, Min Joo Kim, Sun Wook Cho, Su Jin Kim, Eun Jae Jung, June Young Choi, Chang Hwan Ryu, You Jin Lee, Jeong Hun Hah, Yuh Seog Jung, Junsun Ryu, Yunji Hwang, Sue K Park, Ho Kyung Sung, Ka Hee Yi, Do Joon Park, Young Joo Park
BACKGROUND: The ongoing Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) aims to observe the natural course of papillary thyroid microcarcinoma (PTMC), develop a protocol for active surveillance (AS), and compare the long-term prognosis, quality of life, and medical costs between the AS and immediate surgery groups. METHODS: This multicenter prospective cohort study of PTMC started in June 2016. The inclusion criteria were suspicious of malignancy or malignancy based on fine needle aspiration or core needle biopsy, age of ≥18 years, and a maximum diameter of ≤1 cm...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29947182/association-between-serum-fibroblast-growth-factor-21-levels-and-bone-mineral-density-in-postmenopausal-women
#5
Hoon Sung Choi, Hyang Ah Lee, Sang Wook Kim, Eun Hee Cho
BACKGROUND: Despite the beneficial effect of fibroblast growth factor 21 (FGF21) on metabolic disease, there are concerns about adverse effects on bone metabolism, supported by animal studies. However, a recent human study showed the positive association between serum FGF21 level and bone mineral density (BMD) in healthy premenopausal women. We undertook this study to examine the association between FGF21 level and BMD in healthy postmenopausal Korean women who are susceptible to osteoporosis...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29947181/the-status-and-distinct-characteristics-of-endocrine-diseases-in-north-korean-articles-published-between-2006-and-2015
#6
Kyeong Jin Kim, Shin Ha, Yo Han Lee, Jung Hyun Noh, Sin Gon Kim
BACKGROUND: Past decades of division have led to substantial differences in medical environments between South and North Korea. However, little is known about North Korea's medical status and research field, especially regarding endocrinology. In this study, we report the characteristics of North Korea's articles regarding endocrine-related diseases. METHODS: Among the nine medical journals, articles published in Internal Medicine between 2006 and 2015 were reviewed...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29947180/prevalence-and-annual-incidence-of-thyroid-disease-in-korea-from-2006-to-2015-a-nationwide-population-based-cohort-study
#7
Hyemi Kwon, Jin Hyung Jung, Kyung Do Han, Yong Gyu Park, Jung Hwan Cho, Da Young Lee, Ji Min Han, Se Eun Park, Eun Jung Rhee, Won Young Lee
BACKGROUND: The incidence of thyroid nodules has increased worldwide in recent years. Thyroid dysfunction is a potential risk factor for hypercholesterolemia, cardiovascular disease, osteoporosis, arrhythmia, and neuropsychiatric disease. This study investigated the prevalence and annual incidence of thyroid nodules, hypothyroidism, and hyperthyroidism in Koreans. METHODS: In this nationwide population-based cohort study, 51,834,660 subjects were included using the National Health Information database from 2006 to 2015, after the exclusion of subjects with thyroid cancer...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29947179/novel-mutation-in-pthlh-related-to-brachydactyly-type-e2-initially-confused-with-unclassical-pseudopseudohypoparathyroidism
#8
Jihong Bae, Hong Seok Choi, So Young Park, Do Eun Lee, Sihoon Lee
BACKGROUND: Autosomal-dominant brachydactyly type E is a congenital abnormality characterized by small hands and feet, which is a consequence of shortened metacarpals and metatarsals. We recently encountered a young gentleman exhibiting shortening of 4th and 5th fingers and toes. Initially, we suspected him having pseudopseudohypoparathyroidism (PPHP) because of normal biochemical parameters, including electrolyte, Ca, P, and parathyroid hormone (PTH) levels; however, his mother and maternal grandmother had the same conditions in their hands and feet...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29947178/procalcitonin-as-marker-of-recurrent-medullary-thyroid-carcinoma-a-systematic-review-and-meta-analysis
#9
Pierpaolo Trimboli, Luca Giovanella
BACKGROUND: Calcitonin measurement is pivotal in the management of medullary thyroid carcinoma (MTC), but several pitfalls can affect its reliability. Other potential markers have been proposed, and procalcitonin (ProCT) has been reported as promising. The present study was undertaken to summarize the published data and provide more robust estimates on the reliability of ProCT as marker in the management of patients with MTC. METHODS: The systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29947177/parathyroid-hormone-related-protein-in-the-hand-or-out-of-hand
#10
EDITORIAL
Sang Wan Kim
No abstract text is available yet for this article.
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29947176/triennial-report-of-endocrinology-and-metabolism-2015-to-2017
#11
EDITORIAL
Eun Jung Rhee, Hey Yeon Jang, Won Young Lee
No abstract text is available yet for this article.
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29947175/management-of-low-risk-papillary-thyroid-cancer
#12
REVIEW
Nicole M Iñiguez-Ariza, Juan P Brito
The incidence of thyroid cancer has increased, mainly due to the incidental finding of low-risk papillary thyroid cancers (PTC). These malignancies grow slowly, and are unlikely to cause morbidity and mortality. New understanding about the prognosis of tumor features has led to reclassification of many tumors within the low-risk thyroid category, and to the development of a new one "very low-risk tumors." Alternative less aggressive approaches to therapy are now available including active surveillance and minimally invasive interventions...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29947174/genome-wide-association-studies-of-autoimmune-thyroid-diseases-thyroid-function-and-thyroid-cancer
#13
REVIEW
Yul Hwangbo, Young Joo Park
Thyroid diseases, including autoimmune thyroid diseases and thyroid cancer, are known to have high heritability. Family and twin studies have indicated that genetics plays a major role in the development of thyroid diseases. Thyroid function, represented by thyroid stimulating hormone (TSH) and free thyroxine (T4), is also known to be partly genetically determined. Before the era of genome-wide association studies (GWAS), the ability to identify genes responsible for susceptibility to thyroid disease was limited...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29947173/genetic-polymorphism-predisposing-to-differentiated-thyroid-cancer-a-review-of-major-findings-of-the-genome-wide-association-studies
#14
REVIEW
Vladimir A Saenko, Tatiana I Rogounovitch
Thyroid cancer has one of the highest hereditary component among human malignancies as seen in medical epidemiology investigations, suggesting the potential meaningfulness of genetic studies. Here we review researches into genetic variations that influence the chance of developing non-familial differentiated thyroid cancer (DTC), focusing on the major findings of the genome-wide association studies (GWASs) of common single-nucleotide polymorphisms (SNPs). To date, eight GWAS have been performed, and the association of a number of SNPs have been reproduced in dozens of replication investigations across different ethnicities, including Korea and Japan...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29947172/latent-autoimmune-diabetes-in-adults-current-status-and-new-horizons
#15
REVIEW
Paolo Pozzilli, Silvia Pieralice
Autoimmune diabetes is a heterogeneous disease which can arise at any age. Subjects with adult-onset autoimmune diabetes who do not necessitate insulin-therapy for at least 6 months after diagnosis are demarcated as having latent autoimmune diabetes in adults (LADA). This condition is more heterogeneous than young-onset autoimmune diabetes and shares clinical and metabolic characteristics with both type 2 and type 1 diabetes. Patients with LADA are considered by having highly variable β-cell destruction, different degrees of insulin resistance and heterogeneous titre and pattern of islet autoantibody, suggesting different pathophysiological pathways partially explaining the heterogeneous phenotypes of LADA...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29947171/recent-updates-on-the-diagnosis-and-management-of-cushing-s-syndrome
#16
REVIEW
Lynnette K Nieman
Cushing's syndrome, a potentially lethal disorder characterized by endogenous hypercortisolism, may be difficult to recognize, especially when it is mild and the presenting features are common in the general population. However, there is a need to identify the condition at an early stage, as it tends to progress, accruing additional morbidity and increasing mortality rates. Once a clinical suspicion is raised, screening tests involve timed measurement of urine, serum or salivary cortisol at baseline or after administration of dexamethasone, 1 mg...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29766683/star-shaped-intense-uptake-of-%C3%A2-%C3%A2-%C3%A2-i-on-whole-body-scans-can-reflect-good-therapeutic-effects-of-low-dose-radioactive-iodine-treatment-of-1-1-gbq
#17
Sung Hye Kong, Jung Ah Lim, Young Shin Song, Shinje Moon, Ye An Kim, Min Joo Kim, Sun Wook Cho, Jae Hoon Moon, Ka Hee Yi, Do Joon Park, Bo Youn Cho, Young Joo Park
BACKGROUND: After initial radioactive iodine (RAI) treatment in differentiated thyroid cancer patients, we sometimes observe a star-shaped region of intense uptake of ¹³¹I on whole body scans (WBSs), called a 'star artifact.' We evaluated the clinical implications of star artifacts on the success rate of remnant ablation and long-term prognosis. METHODS: Total 636 patients who received ¹³¹I dose of 1.1 GBq for the initial RAI therapy and who did not show distant metastasis at the time of diagnosis were retrospectively evaluated...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29766682/distinct-ultradian-rhythms-in-plasma-clusterin-concentrations-in-lean-and-obese-korean-subjects
#18
Jong Han Choi, Eunheui Jeong, Byung Soo Youn, Min Seon Kim
BACKGROUND: Blood levels of many hormones show rhythmic fluctuations with variable duration of cycles. Clusterin/apolipoprotein J is a glycoprotein which is highly expressed in the plasma and has modulatory roles in immune and inflammatory reactions, neurobiology, lipid metabolism, and leptin signaling. In this study, we examined the diurnal fluctuations of plasma clusterin concentrations in lean and obese young men. METHODS: For the study, 14 subjects (five lean and five obese men; two lean and two obese women) were admitted to the research ward and blood samples were drawn every 30 minutes during light-on period (6:00 AM to 10:00 PM) and every hour during light-off period...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29766681/evaluation-of-thyroid-hormone-levels-and-urinary-iodine-concentrations-in-koreans-based-on-the-data-from-korea-national-health-and-nutrition-examination-survey-vi-2013-to-2015
#19
REVIEW
Jae Hoon Chung
No nationwide data have been published about thyroid hormone levels and urinary iodine concentrations (UICs) in Korea. The Korea Centers for Disease Control and Prevention and the Korean Thyroid Association established a project to evaluate the nationwide thyroid hormone profile and UICs in healthy Koreans as part of the Korea National Health and Nutrition Examination Survey (KNHANES) VI (2013 to 2015), a nationwide, cross-sectional survey of the Korean population that enrolled 7,061 individuals who were weighted to represent the entire Korean population...
June 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29766680/c-arm-computed-tomography-assisted-adrenal-venous-sampling-improved-right-adrenal-vein-cannulation-and-sampling-quality-in-primary-aldosteronism
#20
Chung Hyun Park, Namki Hong, Kichang Han, Sang Wook Kang, Cho Rok Lee, Sungha Park, Yumie Rhee
BACKGROUND: Adrenal venous sampling (AVS) is a gold standard for subtype classification of primary aldosteronism (PA). However, this procedure has a high failure rate because of the anatomical difficulties in accessing the right adrenal vein. We investigated whether C-arm computed tomography-assisted AVS (C-AVS) could improve the success rate of adrenal sampling. METHODS: A total of 156 patients, diagnosed with PA who underwent AVS from May 2004 through April 2017, were included...
June 2018: Endocrinology and Metabolism
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