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Endocrinology and Metabolism

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https://www.readbyqxmd.com/read/28345322/corrigendum-correction-of-acknowledgments-epidemiology-of-childhood-obesity-in-korea
#1
Kyoung Hwa Ha, Dae Jung Kim
This corrects the article on p. 510 in vol. 31, PMID: 27834078.
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28345321/response-comparison-of-age-of-onset-and-frequency-of-diabetic-complications-in-the-very-elderly-patients-with-type-2-diabetes-endocrinol-metab-2016-31-416-23-bong-ki-lee-et-al
#2
LETTER
https://www.readbyqxmd.com/read/28345320/letter-comparison-of-age-of-onset-and-frequency-of-diabetic-complications-in-the-very-elderly-patients-with-type-2-diabetes-endocrinol-metab-2016-31-416-23-bong-ki-lee-et-al
#3
LETTER
https://www.readbyqxmd.com/read/28345319/vascular-cell-adhesion-molecule-1-intercellular-adhesion-molecule-1-and-cluster-of-differentiation-146-levels-in-patients-with-type-2-diabetes-with-complications
#4
F Sinem Hocaoglu-Emre, Devrim Saribal, Guven Yenmis, Guvenc Guvenen
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a multisystemic, chronic disease accompanied by microvascular complications involving various complicated mechanisms. Intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and cluster of differentiation-146 (CD146) are mainly expressed by endothelial cells, and facilitate the adhesion and transmigration of immune cells, leading to inflammation. In the present study, we evaluated the levels of soluble adhesion molecules in patients with microvascular complications of T2DM...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28345318/articles-in-endocrinology-and-metabolism-in-2016
#5
EDITORIAL
Won Young Lee
No abstract text is available yet for this article.
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28345317/how-to-prepare-endocrinology-and-metabolism-for-reapplication-to-medline
#6
EDITORIAL
Sun Huh
No abstract text is available yet for this article.
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28345316/the-implication-of-coronary-artery-calcium-testing-for-cardiovascular-disease-prevention-and-diabetes
#7
REVIEW
Ron Blankstein, Ankur Gupta, Jamal S Rana, Khurram Nasir
Over the last two decades coronary artery calcium (CAC) scanning has emerged as a quick, safe, and inexpensive method to detect the presence of coronary atherosclerosis. Data from multiple studies has shown that compared to individuals who do not have any coronary calcifications, those with severe calcifications (i.e., CAC score >300) have a 10-fold increase in their risk of coronary heart disease events and cardiovascular disease. Conversely, those that have a CAC of 0 have a very low event rate (~0.1%/year), with data that now extends to 15 years in some studies...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28345315/the-role-of-macrophage-lipophagy-in-reverse-cholesterol-transport
#8
REVIEW
Se Jin Jeong, Mi Ni Lee, Goo Taeg Oh
Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28345314/prevalence-and-clinical-characteristics-of-dyslipidemia-in-koreans
#9
REVIEW
Jee Sun Jeong, Hyuk Sang Kwon
The prevalence of hypercholesterolemia in Koreans 30 years old and over was 19.5% in 2015 according to the Korean Nutrition and Health Examination Survey, which means that one-fifth of adults had hypercholesterolemia. The prevalence of hypertriglyceridemia in adults 30 years of age and older was 16.8% in 2015, and men had a 2-fold higher prevalence of hypertriglyceridemia than women (23.9% vs. 10.4%). The awareness of hypercholesterolemia in Koreans was higher in women than among men (62.4% vs. 51.4%). It increased with age; the level of awareness in participants 30 to 49 years of age (32...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28345313/acute-hyperglycemia-associated-with-anti-cancer-medication
#10
REVIEW
Yul Hwangbo, Eun Kyung Lee
Hyperglycemia during chemotherapy occurs in approximately 10% to 30% of patients. Glucocorticoids and L-asparaginase are well known to cause acute hyperglycemia during chemotherapy. Long-term hyperglycemia is also frequently observed, especially in patients with hematologic malignancies treated with L-asparaginase-based regimens and total body irradiation. Glucocorticoid-induced hyperglycemia often develops because of increased insulin resistance, diminished insulin secretion, and exaggerated hepatic glucose output...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28256117/a-simple-outline-of-methods-for-protein-isolation-and-purification
#11
REVIEW
Chang Hun Lee
At the summer workshop of the Korean Endocrine Society held in 2016, some examples of protein experiments were discussed in the session entitled "All about working with proteins." In contrast to what the title suggested, it was unrealistic to comprehensively discuss all protein analytical methods. Therefore, the goal was to outline protein experimental techniques that are useful in research or in bench work. In conversations with clinicians, however, I have always felt that researchers who do not engage in bench science have different demands than those who do...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28256116/lobeglitazone-a-novel-peroxisome-proliferator-activated-receptor-%C3%AE-agonist-attenuates-renal-fibrosis-caused-by-unilateral-ureteral-obstruction-in-mice
#12
Kwi Hyun Bae, Jung Beom Seo, Yun A Jung, Hye Young Seo, Sun Hee Kang, Hui Jeon Jeon, Jae Man Lee, Sungwoo Lee, Jung Guk Kim, In Kyu Lee, Gwon Soo Jung, Keun Gyu Park
BACKGROUND: Renal tubulointerstitial fibrosis is a common feature of the final stage of nearly all cause types of chronic kidney disease. Although classic peroxisome proliferator-activated receptor γ (PPARγ) agonists have a protective effect on diabetic nephropathy, much less is known about their direct effects in renal fibrosis. This study aimed to investigate possible beneficial effects of lobeglitazone, a novel PPARγ agonist, on renal fibrosis in mice. METHODS: We examined the effects of lobeglitazone on renal tubulointerstitial fibrosis in unilateral ureteral obstruction (UUO) induced renal fibrosis mice...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28256115/serum-preadipocyte-factor-1-levels-are-not-associated-with-bone-mineral-density-among-healthy-postmenopausal-korean-women
#13
Hoon Sung Choi, Sang Wook Kim, Eun Hee Cho
BACKGROUND: Multipotent mesenchymal stem cells can differentiate into adipocytes or osteoblasts through closely regulated lineage-control processes. However, adipocyte precursor cells release preadipocyte factor 1 (Pref-1), which inhibits the differentiation of mesenchymal stem cells into mature adipocytes and osteoblasts. Previous studies have also reported an inverse association between Pref-1 levels and bone mineral density (BMD) among patients with anorexia nervosa. METHODS: In this retrospective study, we examined the correlations between Pref-1 levels and BMD among 124 healthy postmenopausal women (>50 years old)...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28256114/development-of-clinical-data-mart-of-hmg-coa-reductase-inhibitor-for-varied-clinical-research
#14
Hun Sung Kim, Hyunah Kim, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Sun Jung Baik, Seung Hwan Lee, Jae Hyoung Cho, In Young Choi, Kun Ho Yoon
BACKGROUND: The increasing use of electronic medical record (EMR) systems for documenting clinical medical data has led to EMR data being increasingly accessed for clinical trials. In this study, a database of patients who were prescribed statins for the first time was developed using EMR data. A clinical data mart (CDM) was developed for cohort study researchers. METHODS: Seoul St. Mary's Hospital implemented a clinical data warehouse (CDW) of data for ~2.8 million patients, 47 million prescription events, and laboratory results for 150 million cases...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28256113/clinical-characteristics-of-patients-with-adrenal-insufficiency-in-a-general-hospital
#15
Ye Yeon Lee, Nan Hee Cho, Jong Won Lee, Nam Kyung Kim, Hye Soon Kim, Mi Kyung Kim
BACKGROUND: Adrenal insufficiency (AI) is a life-threatening disorder caused by the deficiency of adrenal steroid hormones. This retrospective cross-sectional study investigated the characteristics of patients with AI in Korea. METHODS: All consecutive patients with suspected AI who received care at a tertiary referral center in Korea in 2014 and underwent adrenocorticotropic hormone stimulation or insulin-tolerance testing were identified through a review of medical charts...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28256112/the-effects-of-altered-membrane-cholesterol-levels-on-sodium-pump-activity-in-subclinical-hypothyroidism
#16
Suparna Roy, Anindya Dasgupta
BACKGROUND: Metabolic dysfunctions characteristic of overt hypothyroidism (OH) start at the early stage of subclinical hypothyroidism (SCH). Na⁺/K⁺-ATPase (the sodium pump) is a transmembrane enzyme that plays a vital role in cellular activities in combination with membrane lipids. We evaluated the effects of early changes in thyroid hormone and membrane cholesterol on sodium pump activity in SCH and OH patients. METHODS: In 32 SCH patients, 35 OH patients, and 34 euthyroid patients, sodium pump activity and cholesterol levels in red blood cell membranes were measured...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28181428/new-potential-targets-of-glucagon-like-peptide-1-receptor-agonists-in-pancreatic-%C3%AE-cells-and-hepatocytes
#17
REVIEW
Won Young Lee
It is well known that both insulin resistance and decreased insulin secretory capacity are important factors in the pathogenesis of type 2 diabetes mellitus (T2DM). In addition to genetic factors, obesity and lipotoxicity can increase the risk of T2DM. Glucagon-like peptide 1 (GLP-1) receptor agonists are novel antidiabetic drugs with multiple effects. They can stimulate glucose-dependent insulin secretion, inhibit postprandial glucagon release, delay gastric emptying, and induce pancreatic β-cell proliferation...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28181427/risk-of-malignancy-in-thyroid-nodules-4-cm-or-larger
#18
Uchechukwu C Megwalu
BACKGROUND: Several authors have questioned the accuracy of fine-needle aspiration cytology (FNAC) in large nodules. Some surgeons recommend thyroidectomy for nodules ≥4 cm even in the setting of benign FNAC, due to increased risk of malignancy and increased false negative rates in large thyroid nodules. The goal of our study was to evaluate if thyroid nodule size is associated with risk of malignancy, and to evaluate the false negative rate of FNAC for thyroid nodules ≥4 cm in our patient population...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28181426/site-specific-difference-of-bone-geometry-indices-in-hypoparathyroid-patients
#19
Hye Sun Park, Da Hea Seo, Yumie Rhee, Sung Kil Lim
BACKGROUND: Hypoparathyroid patients often have a higher bone mineral density (BMD) than the general population. However, an increase in BMD does not necessarily correlate with a solid bone microstructure. This study aimed to evaluate the bone microstructure of hypoparathyroid patients by using hip structure analysis (HSA). METHODS: Ninety-five hypoparathyroid patients >20 years old were enrolled and 31 of them had eligible data for analyzing bone geometry parameters using HSA...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28116874/thyroid-stimulating-hormone-reference-range-and-prevalence-of-thyroid-dysfunction-in-the-korean-population-korea-national-health-and-nutrition-examination-survey-2013-to-2015
#20
Won Gu Kim, Won Bae Kim, Gyeongji Woo, Hyejin Kim, Yumi Cho, Tae Yong Kim, Sun Wook Kim, Myung Hee Shin, Jin Woo Park, Hai Lin Park, Kyungwon Oh, Jae Hoon Chung
BACKGROUND: No nationwide epidemiological study evaluating the prevalence of subclinical and overt forms of hypothyroidism and hyperthyroidism has yet been conducted in Korea. This study aimed to evaluate the reference range of serum thyroid stimulating hormone (TSH) and the national prevalence of thyroid dysfunctions in Korea. METHODS: Nation-wide cross-sectional data were analyzed from a representative sample of the civilian, non-institutionalized Korean population (n=6,564) who underwent blood testing for thyroid function and anti-thyroid peroxidase antibody (TPOAb) as part of the Korea National Health and Nutrition Examination Survey VI (2013 to 2015)...
March 2017: Endocrinology and Metabolism
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