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Endocrinology and Metabolism

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https://www.readbyqxmd.com/read/27834083/molecular-diagnosis-using-residual-liquid-based-cytology-materials-for-patients-with-nondiagnostic-or-indeterminate-thyroid-nodules
#1
Hyemi Kwon, Won Gu Kim, Markus Eszlinger, Ralf Paschke, Dong Eun Song, Mijin Kim, Suyeon Park, Min Ji Jeon, Tae Yong Kim, Young Kee Shong, Won Bae Kim
BACKGROUND: Molecular analysis for common somatic mutations in thyroid cancer can improve diagnostic accuracy of fine-needle aspiration cytology (FNAC) in the nondiagnostic or indeterminate category of thyroid nodules. In this study, we evaluated the feasibility of molecular diagnosis from residual liquid-based cytology (LBC) material after cytological diagnosis. METHODS: This prospective study enrolled 53 patients with thyroid nodules diagnosed as nondiagnostic, atypia of undetermined significance (AUS), or follicular lesion of undetermined significance (FLUS) after FNAC...
November 4, 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27834082/association-between-obesity-and-bone-mineral-density-by-gender-and-menopausal-status
#2
Mohammad Reza Salamat, Amir Hossein Salamat, Mohsen Janghorbani
BACKGROUND: We investigated whether there were gender differences in the effect of obesity on bone mineral density (BMD) based on menopausal status. METHODS: We assessed 5,892 consecutive patients 20 to 91 years old who were referred for dual-energy X-ray absorptiometry (DXA) scans. All subjects underwent a standard BMD scan of the hip (total hip and femoral neck) and lumbar spine (L1 to L4) using a DXA scan and body size assessment. Body mass index was used to categorize the subjects as normal weight, overweight, and obese...
November 4, 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27834081/current-status-of-bariatric-and-metabolic-surgery-in-korea
#3
REVIEW
Youn Baik Choi
Bariatric surgery is considered to be the most effective treatment modality in maintaining long-term weight reduction and improving obesity-related conditions in morbidly obese patients. In Korea, surgery for morbid obesity was laparoscopic sleeve gastrectomy first performed in 2003. Since 2003, the annual number of bariatric surgeries has markedly increased, including adjustable gastric banding (AGB), Roux-en-Y gastric bypass, sleeve gastrectomy, mini-gastric bypass, and others. In Korea, AGB is much more common than in others countries...
November 4, 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27834080/cardiac-dysfunction-in-association-with-increased-inflammatory-markers-in-primary-aldosteronism
#4
Jung Soo Lim, Sungha Park, Sung Il Park, Young Taik Oh, Eunhee Choi, Jang Young Kim, Yumie Rhee
BACKGROUND: Oxidative stress in primary aldosteronism (PA) is thought to worsen aldosterone-induced damage by activating proinflammatory processes. Therefore, we investigated whether inflammatory markers associated with oxidative stress is increased with negative impacts on heart function as evaluated by echocardiography in patients with PA. METHODS: Thirty-two subjects (mean age, 50.3±11.0 years; 14 males, 18 females) whose aldosterone-renin ratio was more than 30 among patients who visited Severance Hospital since 2010 were enrolled...
November 3, 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27834079/urinary-albumin-excretion-reflects-cardiovascular-risk-in-postmenopausal-women-without-diabetes-the-2011-to-2013-korean-national-health-and-nutrition-examination-survey
#5
Hee Jung Ahn, Do Sik Moon, Da Yeong Kang, Jung In Lee, Da Young Kim, Jin Hwa Kim, Sang Yong Kim, Hak Yeon Bae
BACKGROUND: The objective of the current study was to determine whether there was an association between urinary albumin excretion and cardiovascular disease (CVD) risk by estimating the Framingham Risk Score (FRS) in postmenopausal women without diabetes. METHODS: This study was based on data from the Korea National Health and Nutrition Examination Survey, which was conducted by the Korean Ministry of Health and Welfare in 2011 to 2013. Data on 2,316 postmenopausal women from a total of 24,594 participants was included in the analysis...
November 3, 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27834078/epidemiology-of-childhood-obesity-in-korea
#6
REVIEW
Kyoung Hwa Ha, Dae Jung Kim
Over the past several decades, the prevalence of obesity has increased dramatically worldwide and is increasing not only in developed countries, but also in developing countries. This increase may lead to an increase in the incidence of chronic diseases throughout the lifespan. In Korean children and adolescents, the prevalence of obesity increased from 6.8% in 1998 to 10.0% in 2013. Obesity is a state that more commonly influences children and adolescents of lower socioeconomic status (SES) than those with a higher SES...
November 3, 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27704742/response-the-effects-of-high-fat-diet-and-resveratrol-on-mitochondrial-activity-of-brown-adipocytes-endocrinol-metab-2016-31-328-35-cheol-ryong-ku-et-al
#7
Cheol Ryong Ku, Eun Jig Lee
No abstract text is available yet for this article.
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27704741/letter-the-effects-of-high-fat-diet-and-resveratrol-on-mitochondrial-activity-of-brown-adipocytes-endocrinol-metab-2016-31-328-35-cheol-ryong-ku-et-al
#8
Ji Young Cha
No abstract text is available yet for this article.
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27704740/correlation-of-glypican-4-level-with-basal-active-glucagon-like-peptide-1-level-in-patients-with-type-2-diabetes-mellitus
#9
Sang Ah Lee, Gwanpyo Koh, Suk Ju Cho, So Yeon Yoo, Sang Ouk Chin
BACKGROUND: Previous studies have reported that glypican-4 (GPC4) regulates insulin signaling by interacting with insulin receptor and through adipocyte differentiation. However, GPC4 has not been studied with regard to its effects on clinical factors in patients with type 2 diabetes mellitus (T2DM). We aimed to identify factors associated with GPC4 level in T2DM. METHODS: Between January 2010 and December 2013, we selected 152 subjects with T2DM and collected serum and plasma into tubes pretreated with aprotinin and dipeptidyl peptidase-4 inhibitor to preserve active gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1)...
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27704739/new-biological-markers-of-bone-metabolism-in-osteoporosis-treatment
#10
Sun Wook Cho
No abstract text is available yet for this article.
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27704738/the-revised-2016-korean-thyroid-association-guidelines-for-thyroid-nodules-and-cancers-differences-from-the-2015-american-thyroid-association-guidelines
#11
Ka Hee Yi
Increased detection of thyroid nodules using high-resolution ultrasonography has resulted in a world-wide increase in the incidence of differentiated thyroid cancer (DTC). Despite the steep increase in its incidence, the age-standardized mortality rate of thyroid cancer has remained stable, which leads toward a trend of more conservative treatment. The latest American Thyroid Association (ATA) guidelines for thyroid nodules and thyroid cancer revised in 2015 suggested that fine needle aspiration biopsy should be performed for thyroid nodules larger than 1 cm and lobectomy might be sufficient for 1 to 4 cm intrathyroidal DTC...
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27586452/prognostic-factors-in-patients-hospitalized-with-diabetic-ketoacidosis
#12
Avinash Agarwal, Ambuj Yadav, Manish Gutch, Shuchi Consul, Sukriti Kumar, Ved Prakash, Anil Kumar Gupta, Annesh Bhattacharjee
BACKGROUND: Diabetic ketoacidosis (DKA) is characterized by a biochemical triad of hyperglycemia, acidosis, and ketonemia. This condition is life-threatening despite improvements in diabetic care. The purpose of this study was to evaluate the clinical and biochemical prognostic markers of DKA. We assessed correlations in prognostic markers with DKA-associated morbidity and mortality. METHODS: Two hundred and seventy patients that were hospitalized with DKA over a period of 2 years were evaluated clinically and by laboratory tests...
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27586451/comparison-of-age-of-onset-and-frequency-of-diabetic-complications-in-the-very-elderly-patients-with-type-2-diabetes
#13
Bong Ki Lee, Sang Wook Kim, Daehee Choi, Eun Hee Cho
BACKGROUND: The prevalence of type 2 diabetes in elderly people has increased dramatically in the last few decades. This study was designed to clarify the clinical characteristics of type 2 diabetes in patients aged ≥80 years according to age of onset. METHODS: We reviewed the medical records of 289 patients aged ≥80 years with type 2 diabetes at the outpatient diabetes clinics of Kangwon National University Hospital from September 2010 to June 2014. We divided the patients into middle-age-onset diabetes (onset before 65 years of age) and elderly-onset diabetes (onset at 65+ years of age)...
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27586450/eligibility-for-statin-treatment-in-korean-subjects-with-reduced-renal-function-an-observational-study
#14
Byung Sub Moon, Jongho Kim, Ji Hyun Kim, Young Youl Hyun, Se Eun Park, Hyung Geun Oh, Cheol Young Park, Won Young Lee, Ki Won Oh, Kyu Beck Lee, Hyang Kim, Sung Woo Park, Eun Jung Rhee
BACKGROUND: The purpose of this study was to investigate the relationship between statin eligibility and the degree of renal dysfunction using the Adult Treatment Panel (ATP) III and the American College of Cardiology (ACC)/American Heart Association (AHA) guidelines in Korean adults. METHODS: Renal function was assessed in 18,746 participants of the Kangbuk Samsung Health Study from January 2011 to December 2012. Subjects were divided into three groups according to estimated glomerular filtration rate (eGFR): stage 1, eGFR ≥90 mL/min/1...
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27586449/recent-updates-on-the-management-of-medullary-thyroid-carcinoma
#15
Bo Hyun Kim, In Joo Kim
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor derived from the thyroid C cells producing calcitonin. MTC accounts for 0.6% of all thyroid cancers and incidence of MTC increased steadily between 1997 and 2011 in Korea. It occurs either sporadically or in a hereditary form based on germline rearranged during transfection (RET) mutations. MTC can be cured only by complete resection of the thyroid tumor and any loco-regional metastases. The most appropriate treatment is still less clear in patients with residual or recurrent disease after initial surgery or those with distant metastases because most patients even with metastatic disease have indolent courses with slow progression for several years and MTC is not responsive to either radioactive iodine therapy or thyroid-stimulating hormone suppression...
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27586448/recent-advances-in-autoimmune-thyroid-diseases
#16
Won Sang Yoo, Hyun Kyung Chung
Autoimmune thyroid disease (AITD) includes hyperthyroid Graves disease, hypothyroid autoimmune thyroiditis, and subtle subclinical thyroid dysfunctions. AITD is caused by interactions between genetic and environmental predisposing factors and results in autoimmune deterioration. Data on polymorphisms in the AITD susceptibility genes, related environmental factors, and dysregulation of autoimmune processes have accumulated over time. Over the last decade, there has been progress in the clinical field of AITD with respect to the available diagnostic and therapeutic methods as well as clinical consensus...
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27586447/the-diabetes-epidemic-in-korea
#17
Junghyun Noh
Diabetes is one of the foremost public health issues worldwide that can lead to complications in many organ systems, and has become a significant cause of morbidity and mortality in Korea. According to data from the National Health Insurance Service (NHIS), about 2.7 million Koreans (8.0%) aged 30 years or older had type 2 diabetes mellitus (T2DM) in 2013. The prevalence of T2DM increased with age and rose from 5.6% in 2006 to 8.0% in 2013. Using data based on The Health Screening Service of the NHIS, 25% of Korean adults were reported to have prediabetes in 2013...
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27546873/prevalence-of-hyponatremia-in-hypothyroid-patients-during-radioactive-%C3%A2-%C3%A2-%C3%A2-i-ablation-for-differentiated-thyroid-cancer-single-institution-experience
#18
Juan Carlo P Dayrit, Elaine C Cunanan, Sjoberg A Kho
BACKGROUND: Hyponatremia developing in hypothyroid patients has been encountered in clinical practice; however, its prevalence has not been well established. METHODS: Thirty patients diagnosed with differentiated thyroid cancer, rendered hypothyroid after surgery and levothyroxine withdrawal, and who are for radioactive iodine (RAI) ablation were included. Serum sodium concentrations were measured twice, at the time of admission for RAI ablation, and before discharge after increased oral fluid intake...
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27546872/osteoporosis-and-prevalent-fractures-among-adult-filipino-men-screened-for-bone-mineral-density-in-a-tertiary-hospital
#19
Erick S Mendoza, Amy A Lopez, Valerie Ann U Valdez, Leilani B Mercado-Asis
BACKGROUND: Osteoporosis in men is markedly underdiagnosed and undertreated despite higher morbidity and mortality associated with fractures. This study aimed to characterize adult Filipino men with osteopenia, osteoporosis and prevalent fractures. METHODS: A cross-sectional study of 184 Filipino men ≥50 years screened for bone mineral density was performed. Age, weight, body mass index (BMI), Osteoporosis Self-Assessment Tool for Asians (OSTA) score, smoking status, family history of fracture, diabetes mellitus, physical inactivity, and T-score were considered...
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27546871/update-on-the-management-of-thyroid-disease-during-pregnancy
#20
Chang Hoon Yim
Thyroid dysfunction during pregnancy can result in serious complications for both the mother and infant; however, these complications can be prevented by optimal treatment of maternal overt thyroid dysfunction. Although several studies have demonstrated that maternal subclinical hypothyroidism is associated with obstetric complications and neurocognitive impairments in offspring, there is limited evidence that levothyroxine treatment can improve these complications. Therefore, most professional societies do not recommend universal screening for thyroid dysfunction during pregnancy, and instead recommend a case-finding approach in which only high-risk women are tested...
September 2016: Endocrinology and Metabolism
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