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Middle East Journal of Digestive Diseases

Behrooz Afshar, Anahita Sadeghi, Mohammad Amani, Ali Ali Asgari
Lipoid proteinosis is a rare disorder with autosomal recessive inheritance, characterized by progressive deposition of hyaline material in the skin, mucous membrane, and different organs of the body, resulting in a multitude of clinical manifestations. A 34-year-old woman presented with hoarseness, dysphagia, eyelid beeding, and acneiform scars on the facial skin and extremities. The patient was diagnosed clinically as having lipoid proteinosis, which was confirmed by laryngeal biopsy. The objective of the present report is to describe this rare entity...
January 2018: Middle East Journal of Digestive Diseases
Kyrillus S Shohdy, Wegdan Rashad, Ahmed Elmeligui
Skin manifestations can herald, co-exist, or follow the evolution of inflammatory bowel disease (IBD). We report a middle-aged man with recent onset alopecia universalis and a history of intermittent diarrheal attacks for 6 years. Colonscopy and biopsy sampling confirmed ulcerative colitis. Regrowth of hair was achieved by treating the patient with azathioprine and mesalamine. Clinicians have to be aware that a multitude of skin manifestations with history of diarrhea can be an extraintestinal manifestation of IBD such as ulcerative colitis and this warrants further investigation...
January 2018: Middle East Journal of Digestive Diseases
Reza F Saidi, Seyed Mohammad Kazemaini, Reza Malekzadeh
Liver transplantation (LT) is a lifesaving procedure and the treatment of choice for patients suffering from end-stage liver disease (ESLD). There is increasing number of patients with ESLD in Iran. There is a need to expand and develop new centers to provide better access to LT for patients with ESLD in Iran. This review will address current and future challenges for LT in Iran.
January 2018: Middle East Journal of Digestive Diseases
Afsaneh Bazgir, Mehdi Agha Gholizadeh, Ayyoob Khosravi, Nader Mansour Samaei
BACKGROUND The association between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln gene polymorphism and hepatocellular carcinoma (HCC) has been investigated in several populations. However, the findings are controversial. The aim of this study was to address the association between XRCC1 Arg399Gln polymorphism and HCC in an Iranian population. METHODS We have evaluated the association between XRCC1 Arg399Gln gene polymorphism and HCC in 151 Iranian individuals (50 patients with HCC and 101 healthy matched controls) using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) method...
January 2018: Middle East Journal of Digestive Diseases
Sanaz Ahmadi-Ghezeldasht, Zahra Badiei, Hamid Reza Sima, Mohammad Reza Hedayati-Moghaddam, Meysam Habibi, Mohsen Khamooshi, Ahmad Azimi
BACKGROUND Hepatitis C virus (HCV) is considered to be the major cause of post-transfusion hepatitis in patients with thalassemia. We aimed to determine the HCV prevalence, genotypes, and viral load among patients with major β-thalassemia in Mashhad, Iran. METHODS Medical records of all 550 patients with major β-thalassemia who referred to ThalassemiaHemophilia Center of Mashhad (Sarvar Clinic) were reviewed from October to November 2011. Plasma samples of the patients were tested for the presence of anti-HCV antibodies by enzyme linked immunosorbent assay...
January 2018: Middle East Journal of Digestive Diseases
Seyed Mohsen Dehghani, Maryam Bahmanyar, Hazhir Javaherizadeh
BACKGROUND Caustic ingestion is one of the most important injuries during childhood, which leads to serious sequel. In this study, we evaluated the clinical manifestations, endoscopic appearance, complications, and treatment results in patients with caustic ingestion in our hospital. METHODS Hospital chart of patients with caustic ingestion who admitted to Nemazee Teaching Hospital affiliated to Shiraz University of Medical Sciences during a 2-year period (2015-2016) were reviewed retrospectively. The age, sex, nature of the caustic agent, clinical presentations, grade of injury in endoscopy, degree of parents' education, site of ingestion, accidental or intentional attempts, complications, and outcomes were reviewed...
January 2018: Middle East Journal of Digestive Diseases
Seyed Masih Fatemi, Abbas Doosti, Dariush Shokri, Sadegh Ghorbani-Dalini, Morteza Molazadeh, Hossein Tavakoli, Mohammad Minakari, Hamid Tavakkoli
BACKGROUND Cholecystitis is a common surgical condition. Recently, several authors have reported that DNA of bile tolerant Helicobacter spp. has been found in the human bile colonizing the biliary tract. The aim of this study was to evaluate the association between the presence of Helicobacter spp. and gallstone cholecystitis. METHODS In this case-control study, gallstones, bile, and gallbladder mucosa were collected from 25 patients without gallstone disease, 24 with acute cholecystitis, and 28 with chronic cholecystitis...
January 2018: Middle East Journal of Digestive Diseases
Hooria Momenzadeh, Mitra Mirzai, Zahra Jowkar, Bita Geramizadeh
BACKGROUND Incidence of colorectal cancer is increasing in countries such as Iran. Molecular biomarkers play very important role in the diagnosis, treatment, and prognosis of this cancer. Mutation in the RAS family (including KRAS and NRAS) is one of these important molecular biomarkers, which should be tested before starting treatment with anti-EGRF (Epidermal growth factor) drugs. Objectives: There has been very few reports about the frequency of NRAS mutation from Iran and no study from south of the country...
January 2018: Middle East Journal of Digestive Diseases
Hafez Fakheri, Mehdi Saberi Firoozi, Zohreh Bari
Helicobacter pylori (H. pylori) infection is one of the most common bacterial infections, affecting almost half of the world's population. It is associated with peptic ulcer disease, gastric adenocarcinoma, and lymphoma. In Iran, the prevalence of H. pylori infection has been reported to be between 36% and 90% in different geographic regions. Several studies have assessed the efficacy of different therapeutic options for firstline and second-line H. pylori eradication in Iran; however, the results are conflicting...
January 2018: Middle East Journal of Digestive Diseases
Seyed Farshad Allameh, Morteza Daraie, Reza Taslimi, Nader Roshan, Najmeh Aletaha, Mohsen Nasiri Toosi
No abstract text is available yet for this article.
October 2017: Middle East Journal of Digestive Diseases
Mosayeb Moradniani, Zaker Salehi, Zia Obeidavi
No abstract text is available yet for this article.
October 2017: Middle East Journal of Digestive Diseases
Anahita Sadeghi, Zeinab Naderpour, Mahbube Ebrahimpur, Hiva Saffar
No abstract text is available yet for this article.
October 2017: Middle East Journal of Digestive Diseases
Mahsa Abbaszadeh, Jalal Rezai, Mehrdad Hasibi, Mehrdad Larry, Mohammad Reza Ostovaneh, Sanam Javidanbardan, Seyed Amir Mirbagheri
Pancreatic tuberculosis is extremely rare and its clinical and radiological findings are similar to those of pancreatic malignancy. The diagnosis of pancreatic tuberculosis is not usually made prior to surgery. Here, we report a case of pancreatic tuberculosis, presented with abdominal pain and weight loss. Abdominal computed tomography (CT) showed a 62 mm × 32 mm septate solid-cystic mass in the pancreatic head area with extension into the hilum of the liver. There was no evidence of inflammation or pancreatitis...
October 2017: Middle East Journal of Digestive Diseases
Anahita Sadeghi, Pouya Bastani, Mehdi Mohamadnejad
Inflammatory bowel disease following a solid organ transplantation while the patient is receiving immunosuppressive therapy is a rare phenomenon. Here we present a 48-year-old man who underwent cardiac transplantation 9 years earlier and was receiving cyclosporine as immunosuppressive therapy since then, presenting with complaints of rectorrhagia and diarrhea. In follow-up, he was diagnosed as having ulcerative colitis. We also reviewed the literature for similar cases, which yielded very few similar ones.
October 2017: Middle East Journal of Digestive Diseases
Marjan Mokhtare, Rahele Alimoradzadeh, Shahram Agah, Hossein Mirmiranpour, Niloofar Khodabandehloo
BACKGROUND The effect of changes in intestinal microbiota on constipation is contraversial. Constipation is more prevalent in elderly. Therefore, the current study was designed to assess the role of modulating inflammatory cytokines in old age patients with constipation by evaluating the serum levels of tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-l), and interleukin 6 (IL-6). METHODS This case-control study was done on 100 participants, aged 65 years or higher, with and without functional constipation according to ROME III criteria (50 participants in each group)...
October 2017: Middle East Journal of Digestive Diseases
Morteza Nasiri, Zahra Farsi, Mojtaba Ahangari, Fahimeh Dadgari
BACKGROUND Recent trials have shown controversial results on which enteral feeding methods has a lower risk of enteral feeding intolerance. Therefore, we aimed to compare two methods of bolus and intermittent feeding on enteral feeding intolerance of patients with sepsis. METHODS This triple-blind randomized controlled trial was conducted on 60 patients with sepsis, who were fed through tubes for at least 3 days. The patients were randomly assigned into bolus feeding, intermittent feeding, and control groups...
October 2017: Middle East Journal of Digestive Diseases
Rose Khorasanynejad, Alireza Norouzi, Gholamreza Roshandel, Sima Besharat
BACKGROUND Ideal bowel preparation regimen for a suitable colonoscopy should be safe, and well tolerated, and should rapidly clear gastrointestinal tract. Soluble polyethylene glycol (PEG) is the most common cleansing drug and Senna or C-Lax (Cassia angustifolia Vahl) is an alternative herbal one. This study was designed to compare the efficacy of PEG and C-lax in bowel preparation. METHODS In this randomized double blind trial (registry number in IRCT201601161264N7), 320 patients were randomly assigned in PEG or C-lax groups...
October 2017: Middle East Journal of Digestive Diseases
Kambiz Akhavan Rezayat, Abbas Ali Zeraati, Masoud Pezeshki Rad, Jalal Chogan, Najmeh Davoudian, Amir Akhavan Rezayat, Seyed Mousalreza Hoseini
BACKGROUND One of the earliest diagnostic signs of hepatorenal syndrome in patients suffering from liver cirrhosis is an increase in the renal vascular resistive index (RI). In this study, the impact of propranolol on decreasing this index and to postpone the probability of hepatorenal syndrome has been investigated. METHODS In the current research, 30 patients with liver cirrhosis with different age and sexes have been enrolled. Demographic data and complete medical history have been collected using a specific questionnaire...
October 2017: Middle East Journal of Digestive Diseases
Seyed Alireza Taghavi, Ramin Niknam, Seyed Ehsan Alavi, Fardad Ejtehadi, Gholam Reza Sivandzadeh, Ahad Eshraghian
BACKGROUND Anatomical variations in the biliary system have been proven to be of clinical importance. Awareness of the pattern of these variations in a specific population may help to prevent and manage biliary injuries during surgical and endoscopic procedures. Knowledge of the biliary anatomy will be also of great help in planning the drainage of adequate percentage of liver parenchyma in endoscopic or radiological procedures. METHODS All consecutive patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) from April 2013 to April 2015 at Nemazee Hospital, a referral center in the south of Iran, were included in this cross-sectional study...
October 2017: Middle East Journal of Digestive Diseases
Mehdi Saberifiroozi
Liver cirrhosis is a major chronic disease in the field of digestive diseases. It causes more than one million deaths per year. Despite established evidence based guidelines, the adherence to standard of care or quality indicators are variable. Complete adherence to the recommendations of guidelines is less than 50%. To improve the quality of care in patients with cirrhosis, we need a more holistic view. Because of high rate of death due to cardiovascular disease and neoplasms, the care of comorbid conditions and risk factors such as smoking, hypertension, high blood sugar or cholesterol, would be important in addition to the management of primary liver disease...
October 2017: Middle East Journal of Digestive Diseases
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