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Middle East Journal of Digestive Diseases

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https://www.readbyqxmd.com/read/27957298/resolution-of-bile-duct-adenoma-over-follow-up-period-a-case-report
#1
Mitra Ahadi, Ahmad Khosravi Khorashad, Hassan Saadatnia, Hassan Vosoughinia, Behrooz Davachi, Mohammadreza Farzanehfar, Kamran Ghaffarzadehgan, Bahram Memar, Elham Mokhtari Amirmajdi
Bile duct adenoma (BDA) is a rare neoplasm of bile ducts with various clinical manifestations and imaging appearances. A few cases of BDA and their predisposing factors have been described. We report a 35-year-old woman with right upper quadrant pain who consumed oral contraceptive pills. Ultrasound study revealed three hypoechoic subcapsular liver masses; two of them were hypodense in computed tomography. Fine needle biopsy of the largest mass showed bile duct adenoma. Liver masses disappeared after discontinuing the pills over a 2-year follow-up...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27957297/perforated-meckel-s-diverticulum-in-a-3-day-old-neonate-a-case-report
#2
Mehdi Frooghi, Ali Bahador, Alireza Golchini, Mahmood Haghighat, Maryam Ataollahi, Hazhir Javaherizadeh
Perforation of Meckel's diverticulum is a rare complication in neonatal period. A 3-dayold term male neonate was transferred to our emergency room due to bowel perforation. Surgical exploration was done and perforated Meckel's diverticulum was detected. Pathological report of the tissue showed inflamed diverticulum with heterotopic gastric mucosa. This is the first report of Meckel's diverticulum perforation in a neonate in our country.
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27957296/correlation-between-cut-off-level-of-tissue-transglutaminase-antibody-and-marsh-classification
#3
Azita Ganji, Abbas Esmaeilzadeh, Ali Bahari, Kamran Ghafarzadegan, Mehdi Afzal Aghayee, Homan Mosanen Mozafari, Abdolrasol Hayatbakhsh, Vahid Ghavami Ghanbarabadi, Behdad Ravarian, Leili Rahimi
: BACKGROUND Duodenal biopsy is required for diagnosis of celiac disease in adults, although some studies have suggested adequate accuracy of serology alone. OBJECTIVE: We aimed to assess the correlation between anti-tissue transglutaminase (tTG) titer and pathological findings and to define the specific level of tTG for predicting celiac disease in adults without the need for biopsy sampling. METHODS This descriptive study was done on 299 participants. The tTG titer and pathological findings of duodenal biopsy samples were used for this study...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27957295/review-of-clinical-spectrum-of-gastroesophageal-reflux-disease-in-a-general-population-a-study-from-south-east-iran
#4
Sodaif Darvishmoghadam, Mohammad Javad Zahedi, Mohammad Mehdi Hayatbakhsh Abbasi, Ali Akbar Haghdoost, Mahdieh Khalilyzade, Elham Karimi Goughari
BACKGROUND Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal problems worldwide. The aim of this study was to evaluate the clinical spectrum, prevalence, and some of the variables that are supposed to be the risk factors of this chronic disorder. METHODS This population- based cross-sectional study was conducted in a one-stage randomized clustered sample of adult inhabitants in Kerman city in 2011-2012. A total of 2265 subjects with age range of 15-85 years were enrolled. Face to face interview was performed for all the subjects...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27957294/adult-celiac-disease-patients-are-shorter-compared-with-their-peers-in-the-general-population
#5
Abbas Esmaeilzadeh, Azita Ganji, Ladan Goshayeshi, Kamran Ghafarzadegan, Mehdi Afzal Aghayee, Homan Mosanen Mozafari, Hassan Saadatniya, Abdolrasol Hayatbakhs, Vahid Ghavami Ghanbarabadi
BACKGROUND Delay in diagnosis of celiac disease (CD) occurs frequently, although its consequences are mostly not known. One of the presented symptoms in pediatric patients with CD is the short stature. However, far too little attention has been paid to physical features including height of adult patients with CD. This study was undertaken to evaluate whether patients suffering from CD are shorter in comparison with the general population without CD. As well, we evaluated probable correlations between demographic and physical features, main complains, serum anti tTG level, and intestinal pathology damage between short (lower quartile) versus tall stature (upper quartile) patients with CD...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27957293/hesa-a-effects-on-cell-cycle-signaling-in-esophageal-carcinoma-cell-line
#6
Nasser Ahmadian, Roghiyeh Pashaei-Asl, Nasser Samadi, Mohammad Rahmati-Yamchi, Mohammad-Reza Rashidi, Masomeh Ahmadian, Moosa Esmaeili, Faezeh Salamat, Sima Besharat, Hamid Reza Joshaghani
BACKGROUND Hesa-A is a natural compound with anticancer properties. The exact mechanism of its action in esophageal cancer is not clear, yet. The aim of this study was to evaluate the cell toxicity effect of Hesa-A on the esophageal carcinoma cell lines, KYSE-30, and cell cycle genes expression. METHODS In this study, we tested cell toxicity with MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay and flow cytometry to evaluatet he cell cycle arrest. Real time polymerase chain reaction was used to assess the expression of P53, P16, P21, cyclin D1, and cyclin B1 genes...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27957292/the-effect-of-zinc-supplementationon-the-symptoms-of-gastroesophageal-reflux-disease-a-randomized-clinical-trial
#7
Afshin Shafaghi, Jalal Hasanzadeh, Fariborz Mansour-Ghanaei, Farahnaz Joukar, Maryam Yaseri
BACKGROUND Currently, it has been demonstrated that gastroesophageal reflux disease (GERD) is one of the most important disorders of the digestive system and the commixture of regular diet has a significant influence on its incidence, symptoms, and prognosis. The purpose of this study was to evaluate the effect of zinc supplementation, in combination with PPIs(Proton pump inhibitors), on the improvement of GERD symptoms. METHODS In a randomized double blind clinical trial, patients with reflux symptoms, who had obtained Reflux Disease Questionnaire (RDQ) score more than 8, were included and all the demographic features were recorded...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27957291/a-survey-on-migraine-prevalence-in-patients-with-inflammatory-bowel-disease-a-single-centre-experience
#8
Somaye Chehel Cheraghi, Nasser Ebrahimi Daryani, Mojdeh Ghabaee
BACKGROUND It is hypothesized that migraine may be related to inflammatory bowel disease (IBD), therefore in this cross-sectional study we evaluated the prevalence of migraine in patients with IBD. METHODS In this cross-sectional study 80 patients with IBD and 80 patients without IBD referring to a private gastroenterology clinic from May to January 2014 were evaluated regarding the prevalence of migraine, severity of migraine based on Headache Impact Test (HIT-6), and habits related to headache. RESULTS 160 participants with the mean age of 35 years were evaluated...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27957290/magnetic-resonance-enterography-in-300-known-cases-of-crohn-s-disease-an-initial-report-from-a-referral-center-in-iran
#9
Amir Reza Radmard, Sepehr Haghighi, Amir Pejman Hashemi Taheri, Payam Mohammadinejad, Rana Eftekhar Vaghefi, Sara Naybandi Atashi, Neda Pak, Leila Aghaghazvini, Reza Malekzadeh
BACKGROUND Magnetic resonance enterography (MRE) has become the modality of choice in assessment of patients with Crohn's disease (CD). We aimed to present our experience on 300 patients with CD who underwent MRE during the first 30 months after setting up MRE for the first time in a referral center in Iran. METHODS Patients with a definite diagnosis of CD based on either ileocolonoscopy or histopathological studies were included in the final report and categorized into four phenotypes of inactive, active, stricturing, and penetrating disease...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27957289/efficacy-of-endoscopic-ultrasonography-in-evaluation-of-undetermined-etiology-of-common-bile-duct-dilatation-on-abdominal-ultrasonography
#10
Rasoul Sotoudehmanesh, Naimeh Nejati, Maryam Farsinejad, Shadi Kolahdoozan
BACKGROUND The cause of common bile duct (CBD) dilatation cannot be determined by imaging modalities in many patients. The aim of this study was to assess the value of endoscopic ultrasonography (EUS) in detecting the cause of CBD dilatation in patients in whom ultrasonography could not demonstrate the cause of dilation. METHODS Prospectively, 152 consecutive patients who were referred for evaluation of dilated CBD (diameter ≥7 mm) of undetermined origin by ultrasonography were included in this study. All the patients underwent EUS...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27957288/esophageal-cancer-in-golestan-province-iran-a-review-of-genetic-susceptibility-and-environmental-risk-factors
#11
REVIEW
Mahin Gholipour, Farhad Islami, Gholamreza Roshandel, Masoud Khoshnia, Abbas Badakhshan, Abdolvahab Moradi, Reza Malekzadeh
Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor that is typically diagnosed only when the tumor has gained remarkable size, extended to peripheral tissues, and led to dysphagia. Five-year survival of advanced cancer is still very poor (19%), even with improved surgical techniques and adjuvant chemoradiation therapy. Therefore, early detection and prevention are the most important strategies to reduce the burden of ESCC. Our review will focus on the studies conducted in Golestan province, an area with a high prevalence of ESCC in northern Iran...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27698975/upper-gastrointestinal-bleeding-as-the-first-manifestation-of-wegener-s-granulomatosis
#12
Hamid Tavakkoli, Mehdi Zobeiri, Mansour Salesi, Mohammad Hossein Sanei
Wegener's granulomatosis is an uncommon inflammatory disease that manifests as vasculitis, granulomatosis, and necrosis. It usually involves the upper and lower respiratory tracts and kidneys. Although it may essentially involve any organ, gastrointestinal (GI) involvement is notably uncommon. A 20-year-old male patient presented with epigastric pain, vomiting, hematemesis, and melena. On physical examination, he was pale. There was no abdominal tenderness or organomegaly. Upper GI endoscopy revealed dark blue-colored infiltrative lesions in prepyloric area...
July 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27698974/spyglass-pancreatoscopy-and-successful-retrieval-of-a-proximally-migrated-pancreatic-stent-unusual-case-and-technical-tips
#13
Aliraza Rahimi, Fardad Ejtehadi
Pancreatic stent proximal migration is a well known complication of pancreatic duct stenting, which occurs in about 5-6% of cases. Serious complications should be avoided by retrieval of the stent via different endoscopic techniques. We report a new technique previously reported only once (in a pancreatic duct with underlying pathology), to remove the proximally migrated pancreatic stent in a normal pancreatic duct by SpyGlass Direct Visualization System (Boston Scientific, Natick, Massachusetts, USA) and SpyBite Forceps (Boston Scientific, Natick, Massachusetts, USA)...
July 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27698973/molecular-and-immunohistochemical-study-of-platelet-derived-growth-factor-receptor-alpha-in-kit-negative-gastrointestinal-stromal-tumors-the-first-report-from-iran
#14
Bita Geramizadeh, Zahra Jowkar, Seyed-Javad Mousavi
: BACKGROUND Gastrointestinal stromal tumors (GISTs) are potentially malignant tumors; however their behavior and response to treatment is dependent on the type of mutation and immunohistochemical expression of antigens. It is recommended to perform routine molecular and immunohistochemical tests in KIT and platelet derived growth factor receptor alpha (PDGFRA) molecules for making decision regarding targeted therapy and prediction of the behavior of the tumor. OBJECTIVES: There has been no study from Iran regarding the PDGFRA mutational analysis in GISTs...
July 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27698972/a-comparison-between-hybrid-and-concomitant-regimens-for-helicobacter-pylori-eradication-a-randomized-clinical-trial
#15
Saman Alhooei, Hafez Tirgar Fakheri, Vahid Hosseini, Iradj Maleki, Tarang Taghvaei, Seyed Mohammad Valizadeh, Zohreh Bari
BACKGROUND Helicobacter pylori (H. pylori) is one of the most common bacterial infections worldwide. We designed a study to compare the efficacy of 14-day hybrid regimen with 10-day concomitant therapy for H. pylori eradication in Iran. METHODS 252 patients with naïve H. pylori infection were randomly divided to receive either hybrid regimen (pantoprazole 40 mg, and amoxicillin 1 gr twice daily for 14 days, accompanied by clarithromycin 500 mg, and metronidazole 500 mg, twice daily just during the last 7 days) or concomitant regimen (pantoprazole 40 mg, amoxicillin 1 gr, clarithromycin 500 mg, and metronidazole 500 mg, all twice daily for 10 days)...
July 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27698971/accuracy-of-99mtc-v-dimercaptosuccinic-acid-scintigraphy-and-fecal-calprotectin-compared-with-colonoscopy-in-localizing-active-lesions-in-inflammatory-bowel-disease
#16
Vahid Basirat, Zahra Azizi, Sanam Javid Anbardan, Mina Taghizadeh Asl, Yasaman Farbod, Azam Teimouri, Nasser Ebrahimi Daryani
INTRODUCTION Due to limitation of colonoscopy in assessing the entire bowel and patients' intolerance in inflammatory bowel disease (IBD), in the current study, we aimed to prospectively compare the accuracy of (99m)Tc(V)-dimercaptosuccinic acid (DMSA) and fecal calprotectin with ileocolonoscopy as new methods for localizing inflammations. METHODS Current prospective study conducted between 2012 and 2014 on 30 patients with IBD attending Gastroenterology Clinic of Tehran University of Medical Sciences. Fecal calprotectin and disease activity were measured for all participants and all of them underwent (99m)Tc (V)-DMSA scintigraphy and colonoscopy...
July 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27698970/association-between-pattern-of-gastritis-and-gastroesophageal-reflux-disease-in-patients-with-helicobacter-pylori-infection
#17
Hossein Nobakht, Amirhossein Boghratian, Masoudreza Sohrabi, Mohammad Panahian, Naser Rakhshani, Mehdi Nikkhah, Hossein Ajdarkosh, Gholamreza Hemmasi, Mahmoodreza Khonsari, Ali Gholami, Neda Rabiei, Farhad Zamani
: BACKGROUND Reflux disease is a common gastrointestinal problem. The association between reflux disease and gastritis pattern is controversial. AIM: To determine the association between reflux disease and gastritis pattern in patients with Helicobacter pylori (H. pylori) infection. METHODS 470 patients with dyspepsia and reflux disease were enrolled in this study. The inclusion criteria were willing to participate in the study, age over 40 years, and having the criteria of ROME III for at least 3 months...
July 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27698969/factors-associated-with-outcome-in-patients-with-acute-upper-gastrointestinal-bleeding-in-a-tertiary-referral-center-in-northern-iran
#18
Fatemeh Baradaran, Alireza Norouzi, Samaneh Tavassoli, Abdolvahab Baradaran, Gholamreza Roshandel
BACKGROUND Upper gastrointestinal bleeding (UGIB) is a major healthcare problem and is the most frequent gastrointestinal reason for admission to hospital. We aimed to investigate the prognosis of patients with UGIB referred to a referral hospital in northern Iran in 2013. METHODS All patients with UGIB who admitted to Sayyad Shirazi Hospital, in Gorgan, northern Iran, in 2013 were enrolled. The patients' demographic data as well as data about admission, diseases, drug history, and patients' prognosis were collected by structured questionnaire using information in hospital files...
July 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27698968/seroprevalence-of-hepatitis-e-virus-in-iran-a-systematic-review-and-meta-analysis
#19
Meysam Behzadifar, Kamran B Lankarani, Shadi Abdi, Masood Taheri Mirghaed, Gholam Beyranvand, Abouzar Keshavarzi, Gholamreza Ghoreishinia, Aziz Rezapour, Masoud Behzadifar
BACKGROUND Hepatitis E virus (HEV) is one of common causes of viral hepatitis worldwide with higher prevalence in tropical and subtropical regions. Although epidemics of HEV have been reported from Iran, there are variable reports of this infection out of epidemics from different parts of Iran. This study aimed to determine the seroprevalence of HEV in Iran. METHODS In this systematic review and meta-analysis we searched PubMed, Scopus, Science direct, Google Scholar, Scientific Information Databank (SID), IranMedex, and Magiran for all relevant studies published in either English or Persian languages, up to 2015...
July 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27698967/the-effect-of-probiotic-plus-prebiotic-supplementation-on-the-tolerance-and-efficacy-of-helicobacter-pylori-eradication-quadruple-therapy-a-randomized-prospective-double-blind-controlled-trial
#20
Afshin Shafaghi, Aydin Pourkazemi, Mohsen Khosravani, Saba Fakhrie Asl, Alireza Amir Maafi, Zahra Atrkar Roshan, Jafar Abaspour Rahimabad
BACKGROUND Standard anti-Helicobacter pylori (H. pylori) treatment fails in the eradication of the organism in almost 10-35% of the patients and has different side effects. Recent studies have proposed that probiotic supplementations with or without prebiotic may improve the eradication rate and diminish the side effects, although it is still a controversial issue. We aimed to investigate the effect of probiotic with prebiotic supplementation on the eradication rate and side effects of anti H. pylori quadruple therapy...
July 2016: Middle East Journal of Digestive Diseases
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