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Journal of Movement Disorders

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https://www.readbyqxmd.com/read/28889721/spinal-myoclonus-responding-to-continuous-intrathecal-morphine-pump
#1
Jung-Eun Ahn, Dallah Yoo, Ki-Young Jung, Jong-Min Kim, Beom Seok Jeon, Myung Chong Lee
Spinal myoclonus is a sudden, brief, and involuntary movement of segmental or propriospinal muscle groups. Spinal myoclonus has occasionally been reported in patients undergoing opioid therapy, but the pathophysiology of opioid-induced myoclonus has not been elucidated yet. Here, we present two patients with spinal segmental myoclonus secondary to ischemic and radiation myelopathy. Conventional medications did not help treat persistent myoclonus in both legs. Continuous intrathecal morphine infusion was implanted for pain control in one patient, which relieved spinal myoclonus entirely...
September 12, 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28889720/presynaptic-dopaminergic-degeneration-in-a-patient-with-beta-propeller-protein-associated-neurodegeneration-documented-by-dopamine-transporter-positron-emission-tomography-images-a-case-report
#2
Min Ki Kim, Nan Young Kim, Sangkyoon Hong, Hyeo-Il Ma, Yun Joong Kim
No abstract text is available yet for this article.
September 12, 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28851210/a-comparative-study-of-central-hemodynamics-in-parkinson-s-disease
#3
Joong Hyun Park, Sang Won Han, Jong Sam Baik
Objective: To explore the central aortic pressure in patients with Parkinson's disease (PD). Methods: We investigated central arterial stiffness by measurement of the augmentation index (AIx) in PD patients. Patients were eligible for the study if they were de novo PD and 45 years of age or older. The patients' demographics, vascular risk factors, and neurologic examinations were collected at baseline. The AIx was measured by applanation tonometry. Results: A total of 147 subjects (77 in control and 70 in PD groups) were enrolled in the study...
August 31, 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28851209/quantitative-gait-analysis-in-patients-with-huntington-s-disease
#4
Seon Jong Pyo, Hanjun Kim, Il Soo Kim, Young-Min Park, Mi-Jung Kim, Hye Mi Lee, Seong-Beom Koh
Objective: Gait disturbance is the main factor contributing to a negative impact on quality of life in patients with Huntington's disease (HD). Understanding gait features in patients with HD is essential for planning a successful gait strategy. The aim of this study was to investigate temporospatial gait parameters in patients with HD compared with healthy controls. Methods: We investigated 7 patients with HD. Diagnosis was confirmed by genetic analysis, and patients were evaluated with the Unified Huntington's Disease Rating Scale (UHDRS)...
August 31, 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28782342/-hummingbird-sign-in-a-patient-with-guam-parkinsonism-dementia-complex
#5
Tianrong Yeo, Louis Cs Tan
We present a case of a 71-year-old male Chamorro patient from Guam who presented with progressive supranuclear palsy (PSP)-Richardson's syndrome. Considering his strong family history of parkinsonism and a PSP phenotype, he was clinically diagnosed with Guam parkinsonism-dementia complex (PDC). Magnetic resonance imaging (MRI) of the brain revealed prominent midbrain atrophy with preserved pontine volume, forming the 'hummingbird' sign, which has not been described before in Guam PDC. Molecular analysis of the chromosome 9 open reading frame 72 gene (C9orf72) showed only 6 GGGGCC repeats...
August 8, 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28782341/genetic-screening-for-spinocerebellar-ataxia-genes-in-a-japanese-single-hospital-cohort
#6
Ryuji Sakakibara, Fuyuki Tateno, Masahiko Kishi, Yohei Tsuyusaki, Yosuke Aiba, Hitoshi Terada, Tsutomu Inaoka, Setsu Sawai, Satoshi Kuwabara, Fumio Nomura
Objective: Diagnosis of sporadic cerebellar ataxia is a challenge for neurologists. A wide range of potential causes exist, including chronic alcohol use, multiple system atrophy of cerebellar type (MSA-C), and sporadic late cortical cerebellar atrophy. Recently, an autosomal-dominant spinocerebellar ataxia (SCA) mutation was identified in a cohort of patients with non-MSA-C sporadic cerebellar ataxia. The aim of this study is to genetically screen genes involved in SCA in a Japanese single-hospital cohort...
August 8, 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28704983/a-patient-with-recurrent-dyskinesia-and-hyperpyrexia-syndrome
#7
Min Seok Baek, Hyung Woo Lee, Chul Hyoung Lyoo
Dyskinesia hyperpyrexia syndrome is a rare medical emergency in Parkinson's disease. It is characterized by continuous dyskinesia associated with hyperthermia, rhabdomyolysis, and alteration of the mental state. We present the case of a 74-year-old woman who presented with recurrent dyskinesia hyperpyrexia syndrome. Although some provocation factors and clinical manifestations seem to be shared with parkinsonism hyperpyrexia syndrome, a clear distinction in management should be considered.
July 14, 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28704982/liquid-levodopa-carbidopa-old-solution-forgotten-complication
#8
Nirosen Vijiaratnam, Shuli Cheng, Kelly Lucinda Bertram, David Richard Williams
No abstract text is available yet for this article.
July 14, 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28479587/structure-distribution-and-genetic-profile-of-%C3%AE-synuclein-and-their-potential-clinical-application-in-parkinson-s-disease
#9
Xiaoli Si, Jiali Pu, Baorong Zhang
Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease, is characterized by the loss of nigral dopaminergic neurons. PD leads to a series of clinical symptoms, including motor and non-motor disturbances. α-synuclein, the major component of Lewy bodies, is a hallmark lesion in PD. In this review, we concentrate on presenting the latest research on the structure, distribution, and function of α-synuclein, and its interactions with PD. We also summarize the clinic applications of α-synuclein, which suggest its use as a biomarker, and the latest progress in α-synuclein therapy...
May 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28479586/comparison-of-pallidal-and-subthalamic-deep-brain-stimulation-in-parkinson-s-disease-therapeutic-and-adverse-effects
#10
Ho-Sung Ryu, Mi-Sun Kim, Sooyeoun You, Mi-Jung Kim, Young Jin Kim, Juyeon Kim, Kiju Kim, Sun Ju Chung
OBJECTIVE: To compare the therapeutic and adverse effects of globus pallidus interna (GPi) and subthalamic nucleus (STN) deep brain stimulation (DBS) for the treatment of advanced Parkinson's disease (PD). METHODS: We retrospectively analyzed the clinical data of patients with PD who underwent GPi (n = 14) or STN (n = 28) DBS surgery between April 2002 and May 2014. The subjects were matched for age at surgery and disease duration. The Unified Parkinson's Disease Rating Scale (UPDRS) scores and levodopa equivalent dose (LED) at baseline and 12 months after surgery were used to assess the therapeutic effects of DBS...
May 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28415166/holmes-tremor-with-shoulder-pain-treated-by-deep-brain-stimulation-of-unilateral-ventral-intermediate-thalamic-nucleus-and-globus-pallidus-internus
#11
Sabri Aydın, Huseyin Canaz, Ezgi Tuna Erdogan, Nazlı Durmaz, Barıs Topcular
A 21-year-old male was admitted with severe right arm and hand tremors after a thalamic hemorrhage caused by a traffic accident. He was also suffering from agonizing pain in his right shoulder that manifested after the tremor. Neurologic examination revealed a disabling, severe, and irregular kinetic and postural tremor in the right arm during target-directed movements. There was also an irregular ipsilateral rest tremor and dystonic movements in the distal part of the right arm. The amplitude was moderate at rest and extremely high during kinetic and intentional movements...
May 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28415165/progressive-supranuclear-gaze-palsy-with-predominant-cerebellar-ataxia-a-case-series-with-videos
#12
Zheyu Xu, Tchoyoson C C Lim, Wing Lok Au, Louis C S Tan
Progressive supranuclear palsy (PSP) with predominant cerebellar ataxia (PSP-C) is a rare phenotype of PSP. The clinical and radiological features of this disorder remain poorly characterized. Through a retrospective case series, we aim to characterize the clinical and radiological features of PSP-C. Four patients with PSP-C were identified: patients who presented with prominent cerebellar dysfunction that disappeared with the progression of the disease. Supranuclear gaze palsy occurred at a mean of 2.0 ± 2...
May 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28415164/beyond-the-classic-segawa-disease-gch1-associated-neurodegenerative-parkinsonism-practical-considerations-for-physicians
#13
Jirat Chenbhanich, Jirada Sringean, Roongroj Bhidayasiri
No abstract text is available yet for this article.
May 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28352057/paroxysmal-kinesigenic-dyskinesia-as-the-presenting-and-only-manifestation-of-multiple-sclerosis-after-eighteen-months-of-follow-up
#14
Marius Baguma, Michel Ossemann
Other than tremor, movement disorders are uncommon in multiple sclerosis. Among these uncommon clinical manifestations, paroxysmal kinesigenic dyskinesia is the most frequently reported. It is characterized by episodic attacks of involuntary movements that are induced by repetitive or sudden movements, startling noise or hyperventilation. The diagnosis is essentially clinical and based on a good observation of the attacks. It is very easy to misdiagnose it. We describe the case of a young female patient who presented paroxysmal kinesigenic dyskinesia as the first and only clinical manifestation of multiple sclerosis, with no recurrence of attacks nor any other neurologic symptom after eighteen months of follow-up...
May 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28352056/isolated-neurological-manifestation-in-silent-celiac-disease
#15
Salma Tarabzouni, Thamer AlKhairallah
No abstract text is available yet for this article.
May 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28352055/progressive-encephalomyelitis-with-rigidity-and-myoclonus-in-an-intellectually-disabled-patient-mimicking-neuroleptic-malignant-syndrome
#16
Zheyu Xu, Kalpana Prasad, Tianrong Yeo
We present a case of 32-year-old male with profound mental retardation and autism spectrum disorder who had presented with seizures, rigidity and elevated creatine kinase and was initially diagnosed as neuroleptic malignant syndrome (NMS). The patient subsequently had a complicated clinical course, developing refractory status epilepticus, which lead to the eventual diagnosis of progressive encephalomyelitis with rigidity and myoclonus (PERM). We discuss the clinical similarities and differences between NMS and PERM, and highlight the need to consider alternative diagnoses when the clinical picture of NMS is atypical, particularly in this patient group where the history and clinical examination may be challenging...
May 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28122432/functional-neuroanatomy-for-posture-and-gait-control
#17
REVIEW
Kaoru Takakusaki
Here we argue functional neuroanatomy for posture-gait control. Multi-sensory information such as somatosensory, visual and vestibular sensation act on various areas of the brain so that adaptable posture-gait control can be achieved. Automatic process of gait, which is steady-state stepping movements associating with postural reflexes including headeye coordination accompanied by appropriate alignment of body segments and optimal level of postural muscle tone, is mediated by the descending pathways from the brainstem to the spinal cord...
January 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28122431/validation-of-the-korean-version-of-the-scale-for-outcomes-in-parkinson-s-disease-autonomic
#18
Ji-Young Kim, In-Uk Song, Seong-Beom Koh, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Jin Whan Cho, Yun Joong Kim, Hyeo-Il Ma, Mee-Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeok Lee, Jee-Young Lee, Ji Sun Kim, Ji Young Yun, Hee Jin Kim, Jin Young Hong, Mi-Jung Kim, Jinyoung Youn, Ji Seon Kim, Eung Seok Oh, Hui-Jun Yang, Won Tae Yoon, Sooyeoun You, Kyum-Yil Kwon, Hyung-Eun Park, Su-Yun Lee, Younsoo Kim, Hee-Tae Kim, Joong-Seok Kim
OBJECTIVE: Autonomic symptoms are commonly observed in patients with Parkinson's disease (PD) and often limit the activities of daily living. The Scale for Outcomes in Parkinson's disease-Autonomic (SCOPA-AUT) was developed to evaluate and quantify autonomic symptoms in PD. The goal of this study was to translate the original SCOPA-AUT, which was written in English, into Korean and to evaluate its reliability and validity for Korean PD patients. METHODS: For the translation, the following processes were performed: forward translation, backward translation, expert review, pretest of the pre-final version and development of the final Korean version of SCOPA-AUT (K-SCOPA-AUT)...
January 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28122430/exosome-based-delivery-of-mir-124-in-a-huntington-s-disease-model
#19
Soon-Tae Lee, Wooseok Im, Jae-Jun Ban, Mijung Lee, Keun-Hwa Jung, Sang Kun Lee, Kon Chu, Manho Kim
OBJECTIVE: Huntington's disease (HD) is a genetic neurodegenerative disease that is caused by abnormal CAG expansion. Altered microRNA (miRNA) expression also causes abnormal gene regulation in this neurodegenerative disease. The delivery of abnormally downregulated miRNAs might restore normal gene regulation and have a therapeutic effect. METHODS: We developed an exosome-based delivery method to treat this neurodegenerative disease. miR-124, one of the key miRNAs that is repressed in HD, was stably overexpressed in a stable cell line...
January 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28122429/suspected-perinatal-depression-revealed-to-be-hereditary-diffuse-leukoencephalopathy-with-spheroids
#20
Josefine Blume, Robert Weissert
Early motor symptoms of neurodegenerative diseases often appear in combination with psychiatric symptoms, such as depression or personality changes, and are in danger of being misdiagnosed as psychogenic in young patients. We present the case of a 32-year-old woman who presented with rapid-onset depression, followed by a hypokinetic movement disorder and cognitive decline during pregnancy. Genetic testing revealed a mutation in the colony-stimulating factor 1 receptor gene, which led to the diagnosis of hereditary diffuse leukoencephalopathy with spheroids...
January 2017: Journal of Movement Disorders
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