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Journal of Movement Disorders

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https://www.readbyqxmd.com/read/27667189/survival-of-korean-huntington-s-disease-patients
#1
Han-Joon Kim, Chae-Won Shin, Beomseok Jeon, Hyeyoung Park
OBJECTIVE: The survival of Huntington's disease (HD) patients is reported to be 15-20 years. However, most studies on the survival of HD have been conducted in patients without genetic confirmation with the possible inclusion of non-HD patients, and all studies have been conducted in Western countries. The survival of patients with HD in East Asia, where its prevalence is 10-50-fold lower compared with Western populations, has not yet been reported. METHODS: Forty-seven genetically confirmed Korean HD patients from independent families were included in this retrospective medical record review study...
September 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/27667188/falls-and-their-associated-risks-in-parkinson-s-disease-patients-in-nigeria
#2
Temitope Hannah Farombi, Mayowa O Owolabi, Adesola Ogunniyi
OBJECTIVE: Falls are a devastating consequence of Parkinson's disease (PD) and are due to motor imbalance. However, the frequency of falls and their risk factors among Nigerians with PD is not known despite the significant increase in PD cases in the country. To assess fall risk factors and frequency in Nigerian PD patients. METHODS: Using an analytical design to compare falling versus non-falling patients, 81 PD patients were assessed for clinical factors, frequency of falls, and candidate risk factors for falls according to the Tinetti Balance and Gait, Unified Parkinson's Disease Rating Scale subsection 1, and Timed Up and Go Tests...
September 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/27667187/the-mmse-and-moca-for-screening-cognitive-impairment-in-less-educated-patients-with-parkinson-s-disease
#3
Ji In Kim, Mun Kyung Sunwoo, Young H Sohn, Phil Hyu Lee, Jin Y Hong
OBJECTIVE: To explore whether the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) can be used to screen for dementia or mild cognitive impairment (MCI) in less educated patients with Parkinson's disease (PD). METHODS: We reviewed the medical records of PD patients who had taken the Korean MMSE (K-MMSE), Korean MoCA (K-MoCA), and comprehensive neuropsychological tests. Predictive values of the K-MMSE and K-MoCA for dementia or MCI were analyzed in groups divided by educational level...
September 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/27667186/cognition-and-visit-to-visit-variability-of-blood-pressure-and-heart-rate-in-de-novo-patients-with-parkinson-s-disease
#4
Kyum-Yil Kwon, Seon Jong Pyo, Hye Mi Lee, Woo-Keun Seo, Seong-Beom Koh
OBJECTIVE: We sought to identify whether the characteristics of long-term visit-to-visit blood pressure (BP) and heart rate (HR) are related to baseline cognitive profiles in, Parkinson's disease (PD). METHODS: We selected drug-naïve PD patients who visited our hospital at least 10 times with a baseline assessment of the Seoul neuropsychological battery. BP and HR were measured at each visit, and the variability of the systolic BP/diastolic BP (DBP) and HR was derived from the parameters of serial 10 office visits...
September 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/27667185/applications-of-crispr-cas9-for-gene-editing-in-hereditary-movement-disorders
#5
REVIEW
Wooseok Im, Jangsup Moon, Manho Kim
Gene therapy is a potential therapeutic strategy for treating hereditary movement disorders, including hereditary ataxia, dystonia, Huntington's disease, and Parkinson's disease. Genome editing is a type of genetic engineering in which DNA is inserted, deleted or replaced in the genome using modified nucleases. Recently, clustered regularly interspaced short palindromic repeat/CRISPR associated protein 9 (CRISPR/Cas9) has been used as an essential tool in biotechnology. Cas9 is an RNA-guided DNA endonuclease enzyme that was originally associated with the adaptive immune system of Streptococcus pyogenes and is now being utilized as a genome editing tool to induce double strand breaks in DNA...
September 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/27667184/episodic-ataxias-clinical-and-genetic-features
#6
REVIEW
Kwang-Dong Choi, Jae-Hwan Choi
Episodic ataxia (EA) is a clinically heterogeneous group of disorders that are characterized by recurrent spells of truncal ataxia and incoordination lasting minutes to hours. Most have an autosomal dominant inheritance pattern. To date, 8 subtypes have been defined according to clinical and genetic characteristics, and five genes are known to be linked to EAs. Both EA1 and EA2, which are caused by mutations in KCNA1 and CACNA1A, account for the majority of EA, but many patients with no identified mutations still exhibit EA-like clinical features...
September 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/27240811/woodhouse-sakati-syndrome-report-of-the-first-tunisian-family-with-the-c2orf37-gene-mutation
#7
Olfa Hdiji, Emna Turki, Nouha Bouzidi, Imen Bouchhima, Mariem Damak, Saeed Bohlega, Chokri Mhiri
Woodhouse-Sakati syndrome (WSS) is an infrequent autosomal recessive condition characterized by progressive extrapyramidal signs, mental retardation, hypogonadism, alopecia, and diabetes mellitus. This syndrome belongs to a heterogeneous group of inherited neurodegenerative disorders characterized iron accumulation in the brain, and it is caused by mutations of the C2orf37 gene. We report the first Tunisian family with two affected sisters presenting with a phenotype suggestive of WSS. We examined the index patient presenting with movement disorders and mental retardation and then searched for similar cases in her family, which identified a sister with similar signs...
May 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/27240810/cerebrospinal-fluid-amyloid-%C3%AE-1-42-tau-and-alpha-synuclein-predict-the-heterogeneous-progression-of-cognitive-dysfunction-in-parkinson-s-disease
#8
REVIEW
Ju-Hee Kang
Parkinson's disease (PD) is a neurodegenerative disease with heterogeneous pathological and clinical features. Cognitive dysfunction, a frequent non-motor complication, is a risk factor for poor prognosis and shows inter-individual variation in its progression. Of the clinical studies performed to identify biomarkers of PD progression, the Parkinson's Progression Markers Initiative (PPMI) study is the largest study that enrolled drug-naïve and very early stage PD patients. The baseline characteristics of the PPMI cohort were recently published...
May 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/27240809/movement-disorders-following-cerebrovascular-lesions-in-cerebellar-circuits
#9
REVIEW
Seong-Min Choi
Cerebellar circuitry is important to controlling and modifying motor activity. It conducts the coordination and correction of errors in muscle contractions during active movements. Therefore, cerebrovascular lesions of the cerebellum or its pathways can cause diverse movement disorders, such as action tremor, Holmes' tremor, palatal tremor, asterixis, and dystonia. The pathophysiology of abnormal movements after stroke remains poorly understood. However, due to the current advances in functional neuroimaging, it has recently been described as changes in functional brain networks...
May 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/27240808/movement-disorders-following-cerebrovascular-lesion-in-the-basal-ganglia-circuit
#10
REVIEW
Jinse Park
Movement disorders are primarily associated with the basal ganglia and the thalamus; therefore, movement disorders are more frequently manifest after stroke compared with neurological injuries associated with other structures of the brain. Overall clinical features, such as types of movement disorder, the time of onset and prognosis, are similar with movement disorders after stroke in other structures. Dystonia and chorea are commonly occurring post-stroke movement disorders in basal ganglia circuit, and these disorders rarely present with tremor...
May 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/27240807/movement-disorders-following-cerebrovascular-lesions-etiology-treatment-options-and-prognosis
#11
REVIEW
Do-Young Kwon
Post-stroke movement disorders are uncommon, but comprise an important part of secondary movement disorders. These exert variable and heterogeneous clinical courses according to the stroke lesion and its temporal relationships. Moreover, the predominant stroke symptoms hinder a proper diagnosis in clinical practice. This article describes the etiology, treatment options and prognosis of post-stroke movement disorders.
May 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/27240806/non-invasive-brain-stimulation-for-treatment-of-focal-hand-dystonia-update-and-future-direction
#12
REVIEW
Hyun Joo Cho, Mark Hallett
Focal hand dystonia (FHD) is characterized by excessive and unwanted muscle activation in both the hand and arm resulting in impaired performance in particular tasks. Understanding the pathophysiology of FHD has progressed significantly for several decades and this has led to consideration of other potential therapies such as non-invasive brain stimulation (NIBS). A number of studies have been conducted to develop new therapy for FHD using transcranial magnetic stimulation and transcranial direct current stimulation...
May 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/27020458/movement-disorders-in-non-wilsonian-hepatic-cirrhotic-patients-the-subgroup-analysis-of-various-phenotypes-and-associated-risk-factors
#13
Kulthida Methawasin, Piyanant Chonmaitree, Chatchawan Wongjitrat, Suthee Rattanamongkolgul, Thanin Asawavichienjinda
OBJECTIVE: The aim of this subgroup analysis was to identify the risk factors associated with the development of various movement disorder phenotypes. METHODS: Eighty-three non-Wilsonian cirrhotic patients with abnormal movements were allocated into the following groups: intention tremor, bradykinesia, Parkinsonism, and abnormal ocular movements. These movement types were considered the primary outcomes as there was a sufficient sample size. Researchers took into consideration the gender, etiologies of cirrhosis, cirrhosis-related complications, hepatic encephalopathy, medical illness, and some neurological deficits as potential factors associated with these movement disorders...
May 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/27020457/dropped-head-syndrome-after-minor-trauma-in-a-patient-with-levosulpiride-aggravated-vascular-parkinsonism
#14
Soo Hyun Cho, Dokyung Lee, Tae-Beom Ahn
No abstract text is available yet for this article.
May 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/27020456/cardiovascular-autonomic-dysfunction-in-mild-and-advanced-parkinson-s-disease
#15
Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Sung-Kyung Park, Si-Ryung Han, Kwang-Soo Lee
OBJECTIVE: The purpose of the present study was to investigate cardiovascular autonomic dysfunction in patients with Parkinson's disease (PD) with mild to severe stages of motor symptoms and to compare cardiovascular autonomic dysfunction between drug-naïve and dopaminergic drug-treated groups. METHODS: This study included 188 PD patients and 25 age-matched healthy controls who underwent head-up tilt-testing, 24-h ambulatory blood pressure (BP) monitoring and 24-h Holter monitoring...
May 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/26936443/rapid-eye-movement-sleep-behavior-disorder-in-parkinson-s-disease-a-preliminary-study
#16
Chang Soo Kim, Young Hee Sung, Min Ju Kang, Kee Hyung Park
OBJECTIVE: Rapid eye movement sleep behavior disorder (RBD) is associated with α-synucleinopathies, such as Parkinson's disease (PD). We aimed to assess the differences in the clinical characteristics of PD with and without RBD. METHODS: Forty-two patients previously diagnosed with PD were evaluated for clinical history, motor and cognitive functioning using the Unified Parkinson's Disease Rating Scale (UPDRS) and Mini-Mental State Examination (MMSE), autonomic symptoms, sleep characteristics using the Pittsburg Sleep Quality Index (PSQI), and the presence of RBD using the Korean version of the RBD screening questionnaire (RBDSQ)...
May 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/26936442/tremor-in-a-bassoonist-tremor-in-dystonia-or-essential-tremor
#17
Jung E Park, Vesper Fe Marie L Ramos, Mark Hallett
No abstract text is available yet for this article.
May 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/26828216/acute-chorea-onset-after-hot-food-consumption-in-a-patient-with-moyamoya-disease
#18
Hye Young Jung, Jee Eun Lee, Ilung Kang, Yong Bang Kim, Hyung-Eun Park, Joong-Seok Kim
No abstract text is available yet for this article.
January 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/26828215/reduced-neck-muscle-strength-and-altered-muscle-mechanical-properties-in-cervical-dystonia-following-botulinum-neurotoxin-injections-a-prospective-study
#19
Sirpa Mustalampi, Jari Ylinen, Katariina Korniloff, Adam Weir, Arja Häkkinen
OBJECTIVE: To evaluate changes in the strength and mechanical properties of neck muscles and disability in patients with cervical dystonia (CD) during a 12-week period following botulinum neurotoxin (BoNT) injections. METHODS: Eight patients with CD volunteered for this prospective clinical cohort study. Patients had received BoNT injections regularly in neck muscles at three-month intervals for several years. Maximal isometric neck strength was measured by a dynamometer, and the mechanical properties of the splenius capitis were evaluated using two myotonometers...
January 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/26828214/n30-somatosensory-evoked-potential-is-negatively-correlated-with-motor-function-in-parkinson-s-disease
#20
Suk Yun Kang, Hyeo-Il Ma
OBJECTIVE: The aim of this study was to investigate frontal N30 status in Parkinson's disease (PD) and to examine the correlation between the amplitude of frontal N30 and the severity of motor deficits. METHODS: The frontal N30 was compared between 17 PD patients and 18 healthy volunteers. Correlations between the amplitude of frontal N30 and the Unified Parkinson's Disease Rating Scale (UPDRS) motor score of the more severely affected side was examined. RESULTS: The mean latency of the N30 was not significantly different between patients and healthy volunteers (p = 0...
January 2016: Journal of Movement Disorders
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