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Gastroenterology and Hepatology From Bed to Bench

Adnan Qureshi, Joanne Cunningham, Ravi Madhotra, Jafer Ali, Kamran Rostami
No abstract text is available yet for this article.
2018: Gastroenterology and Hepatology From Bed to Bench
Pantea Tajik, Amir Hossein Goudarzian
A 28-month-old boy with hematochezia for 10 hours was admitted into our hospital. Colonoscopy was performed for the patient in which a mass-like lesion was seen with marron color. The mass suspected intussusception; thus, colonoscopy was interrupted and patient was sent to operation room. After 1 month the patient was good with no abdominal pain or defecation difficulty.
2018: Gastroenterology and Hepatology From Bed to Bench
Dhamia K Suker, Fatimah A Jasim
Aim: The present study designed to evaluate the toxic effect of anatase TiO2 NPs on BALF biochemical changes and liver alteration in rats. Background: Titanium dioxide (TiO2) nanoparticles (NPs) are utilized in food color additives and cosmetics worldwide. Humans uptake these nanoparticulate by different routes and may exhibit potential side effects, lags behind the rapid development of nanotechnology. Methods: Sixty-three mats rats were used...
2018: Gastroenterology and Hepatology From Bed to Bench
Alan Zakko, Paul T Kroner, Rooma Nankani, Raffi Karagozian
Aim: To determine the impact of obesity on development of portal vein thrombosis in cirrhotic patients. Background: Cirrhosis is a known risk factor for portal vein thrombosis (PVT). Evidence also points to obesity as being a risk factor for venous thromboembolism. Limited information is available on how obesity impacts the development of PVT in cirrhotic patients. Methods: This was a retrospective cohort study using the 2013 National Inpatient Sample...
2018: Gastroenterology and Hepatology From Bed to Bench
Babak Sayad, Yosra Naderi, Seyed Moayed Alavian, Farid Najafi, Alireza Janbakhsh, Feyzollah Mansouri, Siavash Vaziri, Mandana Afsharian, Fatemeh Norooznezhad
Aim: This study aimed to determine the seroprevalence and viremic infection of hepatitis delta virus (HDV) in Kermanshah. Background: Hepatitis delta is one of the most complex viral infections of liver that along with hepatitis B virus could lead to fulminant hepatitis, progressive chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Methods: Referrals with positive HBs Ag were included and tested for HDV Ab using ELISA. Seropositives were subsequently evaluated for viremia by assaying HDV RNA and HBV DNA using real-time PCR...
2018: Gastroenterology and Hepatology From Bed to Bench
Hosna Rastegarpouyani, Seyed Reza Mohebbi, Seyed Masoud Hosseini, Pedram Azimzadeh, Sedigheh Beyraghie, Afsaneh Sharifian, Hamid Asadzadeh-Aghdaei, Shahnam Arshi, Mohammad Reza Zali
Aim: In this study, we investigated the prevalence of PARV4 virus among the healthy population and four other groups of HBV infected, HCV infected, HIV infected and HIV/HCV co-infected individuals in Iran. Background: Parvovirus 4 (PARV4) was first discovered in 2005, in a hepatitis B virus-infected injecting drug user (IDU). To date, the best evidence about PARV4 transmission is parenteral roots which comes from IDU individuals. It seems that the prevalence of the virus in the normal population is very low...
2018: Gastroenterology and Hepatology From Bed to Bench
Sara Romani, Seyed Masoud Hosseini, Seyed Reza Mohebbi, Andre Boonstra, Armin Hosseini Razavi, Afsaneh Sharifian
Aim: To determine the distribution of important mutations of the "a" determinant region in the HBV genome among patients in different clinical phases of HBV infection. Background: Variations in Hepatitis B infection not only change the outcome of the disease but also the symptoms from which the chronic HBV patients are suffering. Methods: We have meticulously selected a total of 40 chronic HBV patients from four different subclasses of chronic HBV clinical phases including immune tolerant (IT), immune active (IA), inactive carrier (IC) and hepatitis B e antigen (HBeAg)-negative (ENEG); 10 samples per each phase...
2018: Gastroenterology and Hepatology From Bed to Bench
Adnan Qureshi, Saira BiBi, Ravi Madhotra
Aim: The aim of this study was to determine common factors leading to incomplete colonoscopy with a special interest in patient body mass index (BMI), and also to determine most common second line investigation, its pick up rates for cancer and the success rate of re-scoping. Background: Wide availability of scope guide in all procedures may decrease failure rate. Methods: We retrospectively reviewed 2891 colonoscopies performed at our institution from August 2015 to July 2016...
2018: Gastroenterology and Hepatology From Bed to Bench
Mostafa Rezaei Tavirani, Sina Rezaei Tavirani, Fatemeh Tajik Rostami
Aim: Pathway analysis of gastric atrophy to find new molecular prospective of disease. Background: Gastric atrophy as a process which is accompanied with "loss of glans" in stomach can be considered as a risk factor of gastric cancer. Here, the correlated biochemical pathways to the disorder have been analyzed via protein-protein interaction (PPI) network analysis. Methods: The genes related to gastric atrophy were retrieved by STRING database and organized in a network by Cytoscape...
2018: Gastroenterology and Hepatology From Bed to Bench
Jamshid Yazdani Charati, Ghasem Janbabaei, Nadia Alipour, Soraya Mohammadi, Somayeh Ghorbani Gholiabad, Afsaneh Fendereski
Aim: This study aims to predict survival rate of gastric cancer patients and identify the effective factors related to it, using artificial neural network model. Background: Gastric cancer is the most deadly disease in north and northeast provinces of Iran. A total of 430 patients with gastric cancer who referred to Baghban clinic in Sari, from early November 2006 to late October 2013 were followed. Methods: A historical cohort of patients who referred to Baghban Clinic, the cancer research center of Mazandaran University of Medical Sciences in Sari, from early November 2006 to late October 2013 was studied...
2018: Gastroenterology and Hepatology From Bed to Bench
Somayeh Jahani-Sherafat, Masoud Alebouyeh, Sharareh Moghim, Hamed Ahmadi Amoli, Hajieh Ghasemian-Safaei
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. Lifestyle is identified as one of the most important risk factors for CRC, especially in sporadic colorectal cancer. The natural composition of the gut microbiota changes rapidly during the first decade of life. Maintaining homeostasis in the gut is essential as structural and metabolic functions of the commensal microbiota inhibit gut colonization of pathogens. Dysbiosis, imbalance in function or structure of gut microbiota, has been associated with a variety of diseases, such as colorectal cancer...
2018: Gastroenterology and Hepatology From Bed to Bench
Amir Almasi-Hashiani, Erfan Ayubi, Kamyar Mansori, Mostafa Salehi-Vaziri, Yousef Moradi, Behzad Gholamaliei, Salman Khazaei
Aim: Present study aimed to systematically review and quantitatively synthesize published data about the prevalence of Hepatitis B Virus (HBV) infection among high risk groups in Iran. Background: Determining true burden of Hepatitis B Virus (HBV) infection among high-risk groups relies on knowledge of occurrence measures such as prevalence rate. There is no conclusive and comprehensive data regarding to prevalence of HBV infection among high risk groups in Iran...
2018: Gastroenterology and Hepatology From Bed to Bench
Tagore Sunkara, Megan E Caughey, Vinaya Gaduputi
Melanosis of the stomach and duodenum is a rare entity and a striking finding diagnosed by upper gastrointestinal endoscopy. Here, we describe the case of an 83-year-old female, with a complicated medical history, who was referred to gastroenterologist to assess bleeding risk. From the endoscopy, it was determined that she had both melanosis gastri and duodeni. Although both are rare, gastric melanosis appears to be even more unusual than duodenal melanosis, with only a few reported cases documented in the literature thus far...
2018: Gastroenterology and Hepatology From Bed to Bench
Inamullah Khan Achakzai, Zain Majid, Muhammad Ali Khalid, Shoaib Ahmed Khan, Syed Mudassir Laeeq, Nasir Hassan Luck
A 13-year-old boy, known case renal stone disease came with the complaints of abdominal pain along with low grade fever. On examination, hepatosplenomegaly was noted while his lab reports showed a low hemoglobulin with a raised ESR. His blood and urine cultures showed no growth. Viral markers, autoimmune profile, C and p ANCA were all negative apart from a raised serum IgG level. Ultrasound abdomen showed a hyperechoic liver with an enlarged spleen along with splenic varices and minimum ascites. Ultrasound hepatic doppler was normal...
2018: Gastroenterology and Hepatology From Bed to Bench
Fatemeh Sadat Sadjjadi, Mostafa Rezaie-Tavirani, Nayeb Ali Ahmadi, Seyed Mahmoud Sadjjadi, Hakimeh Zali
Aim: Detection of protein expression changes in human cystic echinococcosis sera by 2D gel electrophoresis. Background: Diagnosis and successful treatment of cystic echinococcosis (CE) is a major challenge, up to now. Identification of related expressed proteins using proteomics tools and bioinformatics analysis of patients' sera have not been investigated, so far. Methods: Sera from eight confirmed CE patients and three healthy controls were collected, tested by 2-DE for total protein separation of serum and analyzed using proteomics and bioinformatics methods...
2018: Gastroenterology and Hepatology From Bed to Bench
Meysam Sharifdini, Amir Keyhani, Mohammad Reza Eshraghian, Eshrat Beigom Kia
Aim: This study is aimed to diagnose and analyze strongyloidiasis in a population of an endemic area of Iran using nested-PCR, coupled with parasitological methods. Background: Screening of strongyloidiasis infected people using reliable diagnostic techniques are essential to decrease the mortality and morbidity associated with this infection. Molecular methods have been proved to be highly sensitive and specific for detection of Strongyloides stercoralis in stool samples...
2018: Gastroenterology and Hepatology From Bed to Bench
Rohollah Taghadosi, Mohammad Reza Shakibaie, Hesam Alizade, Hossein Hosseini-Nave, Asma Askari, Reza Ghanbarpour
Aim: The present study was conducted to detect the occurrence, serogroups, virulence genes and phylogenetic relationship of shiga toxin-producing Escherichia coli (STEC) in human, clave and goat in Kerman (southeast of Iran). Background: STEC have emerged as the important foodborne zoonotic pathogens causing human gastrointestinal disease and confirming the risk to public health. Methods: A total of 671 fecal samples were collected from diarrheic patients (n=395) and healthy calves (n=156) and goats (n=120) and screened for the presence of stx gene...
2018: Gastroenterology and Hepatology From Bed to Bench
Reza Ranjbar, Hedieh Rahmati, Leili Shokoohizadeh
Aim: The aims of this study were to investigate antibiotic resistance pattern and molecular characterization of Salmonella Infantis strains, isolated from human sources in Tehran hospitals from 2008 to 2010. Background: Infection caused by Salmonella is one of the major public health problems. Despite the clinical importance of Salmonella enteric subsp. enteric serovar Infantis in humans, there is no information available about the common clones of Salmonella Infantis in clinical isolates in Iran...
2018: Gastroenterology and Hepatology From Bed to Bench
Miganoosh Simonian, Meysam Mosallayi, Maryam Miraghajani, Awat Feizi, Sharifeh Khosravi, Ahmad Reza Salehi, Deniz Mortazavi, Farideh Saberi, Rasoul Salehi
Aim: In present study we have elucidated the role of 2758 A>G (rs696), in the recognition site of miR449a in the 3' UTR of NFKB inhibitor alpha (NFKBIA) gene, in development of sporadic colorectal cancer. Background: Colorectal cancer (CRC) is rated as second cause of cancer death. Genetic determinants are considered as driving forces in development of sporadic CRC. Single nucleotide polymorphisms (SNPs), are attributed as the main genetic factor in cancers susceptibility...
2018: Gastroenterology and Hepatology From Bed to Bench
Maryam Karkhane, Seyed Reza Mohebbi, Pedram Azimzadeh, Hasti Avarandeh, Shabnam Kazemian, Afsaneh Sharifian, Behzad Hatami, Hamid Asadzadeh Aghdaei
Aim: Our goal was to identify the putative association of rs4072111 variant in IL-16 gene and HCV susceptibility in an Iranian population. Background: Interleukin 16 (IL-16), a multifunctional cytokine, plays a vital role in modulation of immune system. Methods: In present case control and cross sectional study, IL-16 gene variant in 300 patients with hepatitis C (HCV) infection and 300 healthy individuals were analyzed. To evaluate this possible association, genomic DNA from venous blood was extracted and genotypes of IL-16 rs4072111 variant were determined by polymerase chain reaction- Fragments Length Polymorphism Technique (PCR-RFLP)...
2018: Gastroenterology and Hepatology From Bed to Bench
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