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Gastroenterology and Hepatology From Bed to Bench

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https://www.readbyqxmd.com/read/30013753/post-pancreatitis-cholecystectomy-gluten-intolerance
#1
Ivan Tang, George MacFaul, Ravi Madhotra, Kamran Rostami
This case report describes the journey of a patient who suffered from life-limiting gastrointestinal symptoms after an acute bout of pancreatitis following ERCP for cholelithiasis bile following a ductal stone, and subsequent cholecystectomy. She was diagnosed and treated for IBS with medication without significant improvement. On implementation of a simple gluten and lactose exclusion diet she recovered to her premorbid state, and trials of gluten challenge triggered flares of symptoms. This case report will go on to discuss current evidence for use of gluten and lactose exclusion diets in some gluten sensitive patients misdiagnosed with IBS...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013752/detection-of-asymptomatic-celiac-disease-in-two-siblings-from-a-mother-with-non-celiac-gluten-sensitivity
#2
Umberto Volta, Giacomo Caio, Roberto Manfredini, Roberto De Giorgio
Non-celiac gluten sensitivity and celiac disease are known to be two distinct clinical entities, however, non-celiac gluten sensitivity has been detected in a proportion of first-degree relatives of celiac patients. Herein for the first time we describe the occurrence of asymptomatic celiac disease in two siblings, a girl and a boy, whose mother suffered from a proven non-celiac gluten sensitivity. Both the 12-year old girl and 9-year old boy were positive for anti-endomysial and anti-tissue transglutaminase antibodies of IgA class at a very high and low titer, respectively...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013751/an-exploration-into-the-motivation-for-gluten-avoidance-in-the-absence-of-coeliac-disease
#3
Lucy Harper, Justine Bold
Aim: To explore the motivation for gluten avoidance in the absence of coeliac disease (CD) and ascertain what symptoms are triggered by gluten and what beliefs/reasons influence this decision. Background: Links between physical/psychological symptoms and gluten in CD are well known but less is known about those who self-select a gluten-free diet (GFD) in the absence of CD. Methods: An empirical study using responses to an anonymous on-line questionnaire...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013750/a-rapid-and-sensitive-assay-to-identify-hla-dq2-8-risk-alleles-for-celiac-disease-using-real-time-pcr-method
#4
Kazem Mashayekhi, Mohammad Rostami-Nejad, Davar Amani, Mostafa Rezaei-Tavirani, Hamid Mohaghegh-Shalmani, Mohammad Reza Zali
Aim: To perform a simple, rapid and sensitive Real-time PCR based SYBR Green method to determine the human leukocyte antigen (HLA)-DQ 2/8 alleles in celiac disease (CD) patients. Background: Many molecular techniques are available to determine the HLA-DQ2 and DQ8 alleles, but they are too expensive and have many steps that make them difficult to use. Methods: To determine the HLA-DQ 2/8 alleles we have developed a new real-time PCR assay, using SYBR Green technique with melting curve analysis on genomic DNA isolated from 75 CD patients and 94 healthy controls...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013749/prevalence-of-celiac-disease-serological-markers-in-a-cohort-of-italian-rheumatological-patients
#5
Giacomo Caio, Roberto De Giorgio, Francesco Ursini, Silvia Fanaro, Umberto Volta
Aim: To assess the prevalence of celiac disease (CD) serological markers in a cohort of patients referred to an Italian rheumatological outpatient clinic. Background: Current guidelines do not suggest CD screening in patients with rheumatological diseases and these subjects are not considered to be at high risk for CD. Methods: A total of 230 sera of rheumatological patients referred to the Division of Internal Medicine at the Department of Medical and Surgical Sciences between January 2005 and December 2013 were screened for CD by testing IgA antitransglutaminase (TTG IgA), IgG deamidated gliadin peptides (DGP IgG) and IgA antiendomysium (EMA) antibodies...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013748/prevalence-of-celiac-disease-in-iranian-patients-with-rheumatologic-disorders
#6
Elham Elhami, Zahra Zakeri, Amir Sadeghi, Mohammad Rostami-Nejad, Umberto Volta, Mohammad Reza Zali
Aim: Patients with Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), and Fibromyalgia (FM) may have underlying non-diagnosed celiac disease (CD). Background: The aim of this study was to determine the prevalence of CD in patients with these underlying diseases in Iran. Methods: This cross-sectional study was performed among 300 consecutive patients with SLE, RA, and FM (each group 100 patients) since 2015 to 2017. The blood samples were collected and serum IgA anti-tissue trans-glutaminase (Anti-tTG) level was assessed for all patients...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013747/the-influences-of-dried-chicory-root-and-white-lupine-added-to-food-on-jejunal-morphology-experimental-study
#7
Peter Makovicky, Zdenek Volek, Linda Uhlirova, Pavol Makovicky
Aim: The objective of this work was to test the effects of adding dried Chicory root and White lupine food on small bowel morphology and compare it to a standard commercial diet. Background: Various commercial gluten-free products, gluten-free raw materials and gluten-free plants are this time available on the food market, but there are still not enough information about their effect on the small bowel morphology. Methods: Altogether thirty rabbits were used in this study...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013746/pentraxin-3-and-biopsy-status-in-celiac-patients
#8
Roberto Assandri, Alessandro Montanelli
Aim: In our study we explored a possible relationship between PTX3 and CD. Background: Gluten sensitivity is known as a hallmark of celiac disease (CD). The diagnosis of CD requires demonstration of a typical enteropathy, and positive serology supports the diagnosis. The CD immune response involves the adaptive, as well as the innate immunity and is characterized by the presence of anti-gliadin (AGA) and anti-transglutaminase 2 antibodies (tTGA), lymphocytic infiltration in the intestinal epithelial membrane and expression of multiple cytokines...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013745/celiac-disease-microarray-analysis-based-on-system-biology-approach
#9
Mostafa Rezaei Tavirani, Davood Bashash, Fatemeh Tajik Rostami, Sina Rezaei Tavirani, Abdolrahim Nikzamir, Majid Rezaei Tavirani, Mohammad Hossain Haidary
Aim: Aim of this study is screen of the large numbers of related genes of CD to find the key ones. Background: Celiac disease (CD) is known as a gluten sensitive and immune system dependent disease. There are several high throughput investigations about CD but it is necessary to clarify new molecular aspects mechanism of celiac. Methods: Whole-genome profile (RNA) of the human peripheral blood mononuclear cells (PBMCs) as Gene expression profile GSE113469 was retrieved Gene Expression Omnibus (GEO) database...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013744/the-serological-diagnosis-of-coeliac-disease-a-step-forward
#10
REVIEW
Geoffrey Holmes, Carolina Ciacci
The development of highly performing serological tests to identify patients with coeliac disease (CD), allowed large scale screening studies to be carried out and the results transformed our understanding of the prevalence of the condition in the general population. The next logical step was to ask whether CD could be reliably diagnosed by these tests without the need for small intestinal biopsies. This was shown to be the case. Studies from Derby, UK, indicated that about half of adult patients can be diagnosed in this way and similar figures have been provided for children...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013743/biological-markers-for-non-celiac-gluten-sensitivity-a-question-awaiting-for-a-convincing-answer
#11
REVIEW
Enzo Ierardi, Giuseppe Losurdo, Domenico Piscitelli, Floriana Giorgio, Annacinzia Amoruso, Andrea Iannone, Mariabeatrice Principi, Alfredo Di Leo
Non Celiac Gluten Sensitivity (NCGS) is characterized by immunological, morphological or symptomatic manifestations precipitated by gluten ingestion in individuals without celiac disease (CD). The most important challenge in NCGS is the diagnosis, currently based only on clinical observation. The "Salerno criteria" have been pointed out to achieve a reliable diagnosis even if they lack immediacy and practicality, thus making questionable patient's adherence. Therefore, biological indicators supporting the clinical diagnosis of NCGS are advisable...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013742/non-celiac-gluten-sensitivity-and-diagnostic-challenges
#12
REVIEW
Giovanni Casella, Vincenzo Villanacci, Camillo Di Bella, Gabrio Bassotti, Justine Bold, Kamran Rostami
Non-celiac gluten sensitivity (NCGS), also referred to as non-celiac wheat sensitivity (NCWS), is a clinical syndrome characterized by both intestinal and extra-intestinal symptoms responsive to the withdrawal of gluten-containing food from the diet. The aim of this review is to summarize recent advances in research and provide a brief overview of the history of the condition for the benefit of professionals working in gastroenterology. Academic databases such as PubMed and Google Scholar were searched using key words such as "non-celiac gluten sensitivity", "gluten related disorders", and the studies outlined in reference page were selected and analysed...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013741/role-of-biopsy-in-diagnosis-and-treatment-of-adult-celiac-disease
#13
REVIEW
Hugh James Freeman
Celiac disease (CD) is an immune-mediated enteropathy that characteristically responds to treatment with a gluten-free diet. In most, clinical features improve with resolution of diarrhea and weight loss. Serological studies also tend to normalize. Small intestinal biopsies from the duodenum reveal a severe to moderately severe architectural disturbance showing crypt epithelial hyperplasia with increased numbers of epithelial cell mitotic figures along with villous "flattening", increased numbers of lamina propria plasma cells and lymphocytes and increased numbers of intra-epithelial lymphocytes in untreated disease...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013740/exploring-the-villus
#14
REVIEW
Arzu Ensari, Michael N Marsh
The small intestinal villus and its associated epithelium includes enterocytes as the main cell type and differentiated goblet and argentaffin cells, while the invaginated crypt epithelium is the site of cell division and hence the origin of all epithelial components. Enterocytes form a cohesive monolayer which acts both as a permeability barrier between lumen and the interior, and an important gateway for nutrient digestion, absorption and transport. Differentiation and polarisation of enterocytes depends on cytoskeletal proteins that control cell shape and maintain functionally specialised membrane domains; extracellular matrix (ECM) receptors; channels and transporters regulating ion/solute transfer across the cell...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013739/seronegative-coeliac-disease-are-they-coeliac-when-biopsy-in-adult-can-be-avoided
#15
EDITORIAL
Kamran Rostami, David Aldulaimi, Chris J Mulder
No abstract text is available yet for this article.
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/30013738/the-serological-diagnosis-of-adult-coeliac-disease-a-cautious-step-forward
#16
EDITORIAL
Lauren Js Marks, Matthew Kurien, David S Sanders
No abstract text is available yet for this article.
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29910860/a-rare-cause-of-hematemesis
#17
Adnan Qureshi, Joanne Cunningham, Ravi Madhotra, Jafer Ali, Kamran Rostami
No abstract text is available yet for this article.
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29910859/intussusception-of-the-rectum-in-children-a-rare-case-report
#18
Pantea Tajik, Amir Hossein Goudarzian
A 28-month-old boy with hematochezia for 10 hours was admitted into our hospital. Colonoscopy was performed for the patient in which a mass-like lesion was seen with marron color. The mass suspected intussusception; thus, colonoscopy was interrupted and patient was sent to operation room. After 1 month the patient was good with no abdominal pain or defecation difficulty.
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29910858/liver-histopathological-alteration-after-repeated-intra-tracheal-instillation-of-titanium-dioxide-in-male-rats
#19
Dhamia K Suker, Fatimah A Jasim
Aim: The present study designed to evaluate the toxic effect of anatase TiO2 NPs on BALF biochemical changes and liver alteration in rats. Background: Titanium dioxide (TiO2) nanoparticles (NPs) are utilized in food color additives and cosmetics worldwide. Humans uptake these nanoparticulate by different routes and may exhibit potential side effects, lags behind the rapid development of nanotechnology. Methods: Sixty-three mats rats were used...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29910857/obesity-is-not-associated-with-an-increased-risk-of-portal-vein-thrombosis-in-cirrhotic-patients
#20
Alan Zakko, Paul T Kroner, Rooma Nankani, Raffi Karagozian
Aim: To determine the impact of obesity on development of portal vein thrombosis in cirrhotic patients. Background: Cirrhosis is a known risk factor for portal vein thrombosis (PVT). Evidence also points to obesity as being a risk factor for venous thromboembolism. Limited information is available on how obesity impacts the development of PVT in cirrhotic patients. Methods: This was a retrospective cohort study using the 2013 National Inpatient Sample...
2018: Gastroenterology and Hepatology From Bed to Bench
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