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Gastroenterology and Hepatology From Bed to Bench

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https://www.readbyqxmd.com/read/29564071/rare-finding-of-concomitant-pseudomelanosis-of-stomach-and-duodenum-case-report-and-literature-review
#1
Tagore Sunkara, Megan E Caughey, Vinaya Gaduputi
Melanosis of the stomach and duodenum is a rare entity and a striking finding diagnosed by upper gastrointestinal endoscopy. Here, we describe the case of an 83-year-old female, with a complicated medical history, who was referred to gastroenterologist to assess bleeding risk. From the endoscopy, it was determined that she had both melanosis gastri and duodeni. Although both are rare, gastric melanosis appears to be even more unusual than duodenal melanosis, with only a few reported cases documented in the literature thus far...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29564070/hepatic-sarcodosis-presenting-as-portal-hypertension-in-a-young-boy
#2
Inamullah Khan Achakzai, Zain Majid, Muhammad Ali Khalid, Shoaib Ahmed Khan, Syed Mudassir Laeeq, Nasir Hassan Luck
A 13-year-old boy, known case renal stone disease came with the complaints of abdominal pain along with low grade fever. On examination, hepatosplenomegaly was noted while his lab reports showed a low hemoglobulin with a raised ESR. His blood and urine cultures showed no growth. Viral markers, autoimmune profile, C and p ANCA were all negative apart from a raised serum IgG level. Ultrasound abdomen showed a hyperechoic liver with an enlarged spleen along with splenic varices and minimum ascites. Ultrasound hepatic doppler was normal...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29564069/proteome-evaluation-of-human-cystic-echinococcosis-sera-using-two-dimensional-gel-electrophoresis
#3
Fatemeh Sadat Sadjjadi, Mostafa Rezaie-Tavirani, Nayeb Ali Ahmadi, Seyed Mahmoud Sadjjadi, Hakimeh Zali
Aim: Detection of protein expression changes in human cystic echinococcosis sera by 2D gel electrophoresis. Background: Diagnosis and successful treatment of cystic echinococcosis (CE) is a major challenge, up to now. Identification of related expressed proteins using proteomics tools and bioinformatics analysis of patients' sera have not been investigated, so far. Methods: Sera from eight confirmed CE patients and three healthy controls were collected, tested by 2-DE for total protein separation of serum and analyzed using proteomics and bioinformatics methods...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29564068/molecular-diagnosis-of-strongyloidiasis-in-a-population-of-an-endemic-area-through-nested-pcr
#4
Meysam Sharifdini, Amir Keyhani, Mohammad Reza Eshraghian, Eshrat Beigom Kia
Aim: This study is aimed to diagnose and analyze strongyloidiasis in a population of an endemic area of Iran using nested-PCR, coupled with parasitological methods. Background: Screening of strongyloidiasis infected people using reliable diagnostic techniques are essential to decrease the mortality and morbidity associated with this infection. Molecular methods have been proved to be highly sensitive and specific for detection of Strongyloides stercoralis in stool samples...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29564067/serogroups-subtypes-and-virulence-factors-of-shiga-toxin-producing-escherichia-coli-isolated-from-human-calves-and-goats-in-kerman-iran
#5
Rohollah Taghadosi, Mohammad Reza Shakibaie, Hesam Alizade, Hossein Hosseini-Nave, Asma Askari, Reza Ghanbarpour
Aim: The present study was conducted to detect the occurrence, serogroups, virulence genes and phylogenetic relationship of shiga toxin-producing Escherichia coli (STEC) in human, clave and goat in Kerman (southeast of Iran). Background: STEC have emerged as the important foodborne zoonotic pathogens causing human gastrointestinal disease and confirming the risk to public health. Methods: A total of 671 fecal samples were collected from diarrheic patients (n=395) and healthy calves (n=156) and goats (n=120) and screened for the presence of stx gene...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29564066/detection-of-common-clones-of-salmonella-enterica-serotype-infantis-from-human-sources-in-tehran-hospitals
#6
Reza Ranjbar, Hedieh Rahmati, Leili Shokoohizadeh
Aim: The aims of this study were to investigate antibiotic resistance pattern and molecular characterization of Salmonella Infantis strains, isolated from human sources in Tehran hospitals from 2008 to 2010. Background: Infection caused by Salmonella is one of the major public health problems. Despite the clinical importance of Salmonella enteric subsp. enteric serovar Infantis in humans, there is no information available about the common clones of Salmonella Infantis in clinical isolates in Iran...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29564065/single-nucleotide-polymorphism-rs696-in-mir449a-binding-site-of-nfkbia-gene-is-correlated-with-risk-of-colorectal-cancer
#7
Miganoosh Simonian, Meysam Mosallayi, Maryam Miraghajani, Awat Feizi, Sharifeh Khosravi, Ahmad Reza Salehi, Deniz Mortazavi, Farideh Saberi, Rasoul Salehi
Aim: In present study we have elucidated the role of 2758 A>G (rs696), in the recognition site of miR449a in the 3' UTR of NFKB inhibitor alpha (NFKBIA) gene, in development of sporadic colorectal cancer. Background: Colorectal cancer (CRC) is rated as second cause of cancer death. Genetic determinants are considered as driving forces in development of sporadic CRC. Single nucleotide polymorphisms (SNPs), are attributed as the main genetic factor in cancers susceptibility...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29564064/genetic-association-between-a-single-nucleotide-polymorphism-in-interleukin-16-rs4072111-and-susceptibility-to-chronic-hcv-infection-in-an-iranian-population
#8
Maryam Karkhane, Seyed Reza Mohebbi, Pedram Azimzadeh, Hasti Avarandeh, Shabnam Kazemian, Afsaneh Sharifian, Behzad Hatami, Hamid Asadzadeh Aghdaei
Aim: Our goal was to identify the putative association of rs4072111 variant in IL-16 gene and HCV susceptibility in an Iranian population. Background: Interleukin 16 (IL-16), a multifunctional cytokine, plays a vital role in modulation of immune system. Methods: In present case control and cross sectional study, IL-16 gene variant in 300 patients with hepatitis C (HCV) infection and 300 healthy individuals were analyzed. To evaluate this possible association, genomic DNA from venous blood was extracted and genotypes of IL-16 rs4072111 variant were determined by polymerase chain reaction- Fragments Length Polymorphism Technique (PCR-RFLP)...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29564063/extracted-metabolite-from-streptomyces-levis-abriinw111-altered-the-gene-expression-in-colon-cancer
#9
Parisa Fatourachi, Behnaz Faramarziyan Azimi Maragheh, Seyede Momeneh Mohammadi, Behnaz Valipour, Alireza Dehnad, Hojjatollah Nozad Charoudeh
Aim: In this study we attempt to indicate anti-carcinogenic influence of ether extracted metabolites of Streptomyces Levis sp. on gene expression in colon cancer. Background: Colon cancer is one of the most prevalent cancers worldwide. In recent decades, researchers have been seeking the treatment for cancer. Natural products are valuable compounds with fewer side effects in comparison to chemotherapy drugs. Methods: Secondary metabolites were extracted with the inoculation of bacterial sample in Mueller Hinton Broth...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29564062/protein-protein-interaction-analysis-of-alzheimer-s-disease-and-nafld-based-on-systems-biology-methods-unhide-common-ancestor-pathways
#10
Reza Karbalaei, Marzieh Allahyari, Mostafa Rezaei-Tavirani, Hamid Asadzadeh-Aghdaei, Mohammad Reza Zali
Aim: Analysis reconstruction networks from two diseases, NAFLD and Alzheimer`s diseases and their relationship based on systems biology methods. Background: NAFLD and Alzheimer`s diseases are two complex diseases, with progressive prevalence and high cost for countries. There are some reports on relation and same spreading pathways of these two diseases. In addition, they have some similar risk factors, exclusively lifestyle such as feeding, exercises and so on...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29564061/levofloxacin-based-vs-clarithromycin-based-sequential-therapy-in-helicobacter-pylori-eradication-a-randomized-clinical-trial
#11
Mosayeb Moradniani, Zohre Mirbeik-Sabzevari, Soleiman Jaferian, Shiva Shafiezadeh, Mohammad Javad Ehsani Ardakani, Mehrdad Mirzaee Roozbahany, Saleh Azadbakht, Hamidreza Sherkatolabbasieh
Aim: This study was aimed to evaluating the efficacy of levofloxacin based sequential therapy vs clarithromycin based sequential therapy in h.pylori (HP) eradication. Background: Several therapeutic regimen were investigated to treat HP infection. Sequential therapy is an alternative to classic triple therapy. Methods: In this randomized clinical trial, 200 HP infected patients randomly divided into two therapeutic groups .1-Levofloxacin based sequential regimen (group A); omeprazole and amoxicillin for 7days followed by omeprazole, amoxicillin and levofloxacin for 7days...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29564060/comparison-of-helicobacter-pylori-eradication-regimens-in-patients-with-end-stage-renal-disease
#12
Mohammadreza Seyyed Majidi, Peyman Sanjari Pirayvatlou, Majid Rajabikashani, Mona Firoozabadi, Seyed Ali Seyed Majidi, Jamshid Vafaeimanesh
Aim: The aim of this study was to compare the Helicobacter pylori (HP) eradication regimens in patients with end stage renal disease. Background: In patients undergoing hemodialysis, the pathologic changes seen in the stomach may be the result of high serum levels of gastrin, delayed gastric emptying or HP infection. Methods: Our study was a randomized clinical trial in which 120 patients with ESRD (Patients who undergo hemodialysis) confirmed HP infection, were divided to four groups having 2-week eradication regimens; Group I: LCA (lansoprazole 30 mg-BD,clarithromycin 250 mg-BD, amoxicillin 500 mg-BD), Group II: LCM (lansoprazole 30 mg-BD,clarithromycin 250 mg-BD, metronidazole 500 mg-BD), Group III: LCAM (lansoprazole 30 mg-BD,clarithromycin 250 mg-BD,amoxicillin 500 mg-BD, metronidazole 500 mg-BD) and Group IV: Sequential (lansoprazole 30 mg-BDfor two weeks; first week: amoxicillin 500 mg-BD and second week: clarithromycin 250 mg-BD, metronidazole 500 mg-BD)...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29564059/is-treatment-of-fatty-liver-effective-on-reducing-carotid-intima-media-thickness-a-cohort-study
#13
Saeideh Ghaffarifar, Manouchehr Khoshbaten, Fattaneh Dordaei, Maryam Zareh Nahandi, Reza Javad-Rashid, Tahereh Shahnazi
Aim: This study was intended to explore the effect of various drugs used to treat fatty liver on intimal-media thickness in patients with NAFLD. Background: Nonalcoholic fatty liver disease (NAFLD) is an indicator of a broad spectrum of pathologic disorders, which is characterized with macro vesicular steatosis in the absent of alcohol use. It has a wide range of laboratory, clinical and pathological presentations such as simple steatosis to the diseases like non-alcoholic steatohepatitis, fibrosis, and cirrhosis and hepatocellular cancer...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29564058/faecal-microbiota-transplantation-looking-beyond-clostridium-difficile-infection-at-inflammatory-bowel-disease
#14
REVIEW
Krish Patel, Amee Patel, David Hawes, Janki Shah, Krishna Shah
Gastrointestinal (GI) microbiota are known to play paramount role in inflammatory bowel disease (IBD). Innovative sequencing methods have radically expanded our ability to analyze the intestinal microbiome. However, alterations of the GI microbiome in IBD have not yet been fully evaluated. Irregular colonization of the gut has been implicated in chronic intestinal inflammation. Faecal microbiota transplantation (FMT) is a procedure which aims to restore microbial disturbances to the individual's gut microbiome...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29511487/eosinophilic-gastroenteritis-a-report-of-two-cases-with-different-presentations
#15
Amir Sadeghi, Elham Abdi, Negin Jamshidfar, Farnoush Barzegar, Farhad Lahmi
Eosinophilic gastroenteritis is a rare inflammatory disease, defined by infiltration of eosinophils in gastrointestinal (GI) tract, but the etiology of this disorder is unknown. Depends on the involvement region of Eosinophilic gastroenteritis, GI symptoms are variable including abdominal pain, malabsorption, gastric and duodenal ulcer. Due to its non-specific symptoms, the diagnosis is based on upper GI endoscopy followed by histopathological examination of the biopsies, which shows eosinophilic infiltration in different layers of GI tract...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29511486/interleukin-21-rs2055979-and-interleukin-21-receptor-rs3093390-genetic-variants-and-hepatitis-c-virus-chronic-infection
#16
Shahrzad Shoraka, Seyed Reza Mohebbi, Seyed Masoud Hosseini, Armin Hosseini Razavi, Amir Ghaemi, Shabnam Kazemian, Mohammad Rostami-Nejad
Aim: The aim of this case-control study was to investigate association of G/T IL-21 (rs2055979) and C/T IL-21R (rs3093390) gene polymorphisms with chronic hepatitis C virus in Iranian Patients. Background: Interleukin 21 (IL-21) has a significant function in the regulation of cellular immune responses. Its exclusive receptor, IL-21R, expressed on the surface of T, B and NK cells and is important for the proliferation and differentiation of these immune cells. Hence, it was suggested to be involved in response to viral infections...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29511485/protein-interaction-mapping-interpretation-of-none-alcoholic-fatty-liver-disease-model-of-rats-after-fat-diet-feeding
#17
Hamed Abdollahi, Mona Zamanian Azodi, Behzad Hatami
Aim: This study investigates the effect of fat diet on gene expression profile in rat liver via protein-protein interaction mapping analysis. Background: Nonalcoholic fatty liver disease (NAFLD) is a prevalent condition of liver in the world. This progressive metabolic disease is representative with fat accumulation in the patients' liver that can led to advance stages, namely, cirrhosis and eventually cancer. Methods: Differentially expressed genes of NAFLD rat liver after 2, 4 and 6 weeks fat diet feeding were analyzed via GEO2R and protein-protein interaction network by Cytoscape v3...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29511484/protein-profiling-of-infected-human-gastric-epithelial-cells-with-an-iranian-helicobacter-pylori-clinical-isolate
#18
Zeinab Fazeli, Masoud Alebouyeh, Vahid Mansouri, Habib Malekpour
Aim: The main objective of this study was to use high throughput approach to characterize the response of human gastric epithelial cells to Helicobacter pylori ( H. pylori ) infection at protein level. Background: Alteration of host cell protein profiles occurs due to H. pylori infection. This alteration seems to be strain specific. High throughput approaches, such as proteomics, can describe changes that occurs at the protein levelin the infected cells in response to H...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29511483/evaluation-of-involved-proteins-in-colon-adenocarcinoma-an-interactome-analysis
#19
Reza Valizadeh, Ayad Bahadorimonfared, Mostafa Rezaei-Tavirani, Mohsen Norouzinia, Mohammad Iavad Ehsani Ardakani
Aim: Assessment of related genes to colon cancer to introduce crucial ones, was the aim of this research. Background: Colon cancer is one of the invasive colorectal diseases. This disease is preventable and manageable if it be diagnosed in early stage. The aggressive tools for its detection imply more investigation for new molecular diagnostic methods. Methods: Numbers of 300 genes from String database (SD) are analyzed via constructed Protein-protein interaction (PPI) network by Cytoscape software 3...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29511482/development-of-experimental-fibrotic-liver-diseases-animal-model-by-carbon-tetracholoride
#20
Atoosa Gitiara, Samaneh Tokhanbigli, Sogol Mazhari, Kaveh Baghaei, Behzad Hatami, Seyed Mahmoud Hashemi, Ali Asadi Rad, Afshin Moradi, Meyam Nasiri, Nakisa Zarrabi Ahrabi, Mohammad Reza Zali
Aim: This study is presenting an effective method of inducing liver fibrosis by CCL4 as a toxin in two different breeds of rat models. Background: Liver fibrosis is a result of inflammation and liver injury caused by wound healing responses which ultimately lead to liver failure. Consequently, after liver fibrosis, the progression will be continued to liver cirrhosis and at the end stage hepatocellular carcinoma (HCC). Many studies have demonstrated that one of the most important causes of liver fibrosis is Non-alcoholic steatohepatitis (NASH)...
2017: Gastroenterology and Hepatology From Bed to Bench
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