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Gastroenterology and Hepatology From Bed to Bench

Beata Polewiczowska, David Aldulaimi
No abstract text is available yet for this article.
2017: Gastroenterology and Hepatology From Bed to Bench
Negar Azarpira, Akbar Safaie, Ahmad Monabati, Masudd Hosseinzadeh, Sadat Noori, Maryam Moini, Alireza Rahimi, Tahereh Heidari, Marjan Rahsaz
Anaplastic large cell lymphoma (ALCL) is a distinct pathologic entity with characteristic morphologic, im¬munophenotypic and cytogenetic features. Obstructive symptoms are rare presentation of ALCL. We report a 16-year-old boy who initially presented with dysphagia. Upper gastrointestinal endoscopy revealed severe stenosis with an infiltrative process starting from 24 cm of incisors in lower esophagus Esophageal mucosal biopsy demonstrated lymphomatous involvement that ancillary tests confirmed the diagnosis of ALCL, ALK (kinase-positive), and PAX5 positive...
2017: Gastroenterology and Hepatology From Bed to Bench
Roberto Assandri, Federico Serana, Alessandro Montanelli
Chronic Graft versus Host Disease (cGVHD) is a complex disease resulting from donor T-cell recognition of a genetically disparate recipient that is unable to reject donor cells after allogeneic Stem Cell Transplantation (HSCT). cGVHD has some features resembling to autoimmune diseases (AD) such as Sjögren syndrome, primary biliary cirrhosis (PBC) and scleroderma (SSc). Also patients with cGVHD could develop extensive cGVHD with scleroderma-like skin manifestations and other clinical signs similar to those of patients with scleroderma...
2017: Gastroenterology and Hepatology From Bed to Bench
Leili Shokoohizadeh, Gholam Abbas Kaydani, Alireza Ekrami
Aim: In This study focused on the detection of dominant clones and genetic relationship of Shigella spp. isolated from children with diarrhea in the main pediatric hospital in Ahvaz by multi-locus sequence typing (MLST) technique. Background: Shigellosis is considered as one of the problematic bacterial infections for public health in the world. Khuzestan province in the Southwestern part of Iran is a known endemic area for infections due to Shigella. There are limited molecular epidemiological data for Shigella spp...
2017: Gastroenterology and Hepatology From Bed to Bench
Shehla Khalil, Bijay Ranjan Mirdha, Ashutosh Panda, Yogita Singh, Govind Makharia, Jaishree Paul
Aim: Present hospital based study was carried out at our tertiary care centre with an aim to study the distribution of Cryptosporidium species subtypes in patients with complaints of diarrhea. Background: Cryptosporidium species are one of the important causative agents of parasitic diarrhea, amongst which Cryptosporidium hominis (C.hominis) and Cryptosporidium parvum (C.parvum) are the two major species that are associated with human cryptosporidiosis. Methods: Four hundred and fifty (n=450) diarrheic patients complaining of different types of diarrhea were enrolled in the present study...
2017: Gastroenterology and Hepatology From Bed to Bench
Fereshteh Izadi, Mostafa Rezaei Tavirani, Zahra Honarkar, Mohammad Rostami-Nejad
Aim: we mainly aimed to elucidate potential comorbidities between celiac disease and hepatitis c by means of data and network analysis approaches. Background: understanding the association among the disorders evidently has important impact on the diagnosis and therapeutic approaches. Celiac disease is the most challenging, common types of autoimmune disorders. On the other hand, hepatitis c virus genome products like some proteins are supposed to be resemble to gliadin types that in turn activates gluten intolerance in people with inclined to gluten susceptibilities...
2017: Gastroenterology and Hepatology From Bed to Bench
Padina Vaseghi Maghvan, Mostafa Rezaei-Tavirani, Hakimeh Zali, Abdolrahim Nikzamir, Saeed Abdi, Mahsa Khodadoostan, Hamid Asadzadeh-Aghdaei
Aim: The aim of this study was to provide a biomarker panel for esophageal, gastric and colorectal cancers. It can help introducing some diagnostic biomarkers for these diseases. Background: Gastrointestinal cancers (GICs) including esophageal, gastric and colorectal cancers are the most common cancers in the world which are usually diagnosed in the final stages and due to heterogeneity of these diseases, the treatments usually are not successful. For this reason, many studies have been conducted to discover predictive biomarkers...
2017: Gastroenterology and Hepatology From Bed to Bench
Marjan Mokhtare, Seyed-Mohammad-Sadegh Ghafoori, Mojtaba Soltani-Kermanshahi, Amir-Hosein Boghratian, Shahram Agah, Mehrdad Sheikhvatan
Aim: The present study aimed to assess the reliability and validity of Persian version of patient assessment of constipation: quality of life (PAC-QOL) questionnaire in Iranian patients. Background: Chronic constipation has significant effects on daily living, wellbeing and individuals' quality of life (QOL). Validated tools can help us to assessing QOL in affected ones and facilitating clinical management of them. Methods: The English version of Patient Assessment of Constipation: Quality of Life (PAC-QOL) was translated into the Persian language and was confirmed by back-translation...
2017: Gastroenterology and Hepatology From Bed to Bench
Mehdi Gholizadeh, Ayyoob Khosravi, Pedram Torabian, Naghmeh Gholipoor, Nader Mansour Samaei
Aim: The aim of this study was to address the association of the EGF gene +61A/G polymorphisms and HCC susceptibility in an Iranian population. Background: The association of epidermal growth factor (EGF) gene +61A/G polymorphism (rs4444903) and hepatocellular carcinoma (HCC) has been investigated in several populations. However, the findings are controversial. Methods: A total of 40 unrelated HCC patients and 106 healthy individuals were enrolled in this study...
2017: Gastroenterology and Hepatology From Bed to Bench
Salem Youssef Mohamed, Ehab Fawzy Mostafa, Amr Shaaban Hanafy, Hesham Atia, Ashraf Metwally, Ayman M Marei
Aim: The objective of this work is to find out whether there is a relation between the expression of TLR4 and fibrosis progression in chronic HCV patients. Background: Toll-like Receptor 4 (TLR4) is a pattern recognition receptor whose activation results in the production of several pro-inflammatory cytokines. Methods: Fifty patients with chronic HCV were included. They were divided into group A: 40 patients (F1-F4) and group B (control group) which included ten patients (F0) based on fibroscan value...
2017: Gastroenterology and Hepatology From Bed to Bench
Razieh Dowran, Jamal Sarvari, Afagh Moattari, Mohammad-Reza Fattahi, Amin Ramezani, Seyed Younes Hosseini
Aim: To evaluate the baseline expression of the immune genes in PBMCs of responder and non-responder patients with chronic Hepatitis C. Background: Although the contribution of peripheral blood mononuclear cell (PBMC) gene expression in treatment outcome of hepatitis C virus (HCV) infection is supposed, it has remained to be distinctly delineated. The baseline expression of the immune genes inside PBMCs may reflect the responsiveness status following IFN treatment...
2017: Gastroenterology and Hepatology From Bed to Bench
Sorur Javanmardifard, Fariba Ghodsbin, Mohammad Javad Kaviani, Iran Jahanbin
Aim: This study aimed to assess the effect of telenursing on nutritional behavior and physical activity self-efficacy in patients with non-alcoholic fatty liver disease (NAFLD). Background: NAFLD is the most common liver disorder, which has a chronic course. Therefore, routine monitoring of these patients by medical staff helps them actively participate in the healing process and promote their self-efficacy. Methods: In this randomized controlled clinical trial, 60 patients were chosen through convenience sampling among patients with NAFLD...
2017: Gastroenterology and Hepatology From Bed to Bench
Mohamad Amin Pourhoseingholi, Mohammad Rostami-Nejad, Farnoush Barzegar, Kamran Rostami, Umberto Volta, Amir Sadeghi, Zahra Honarkar, Niloofar Salehi, Hamid Asadzadeh-Aghdaei, Ahmad Reza Baghestani, Mohammad Reza Zali
Aim: The aim of this study was to estimate the economic burden of celiac disease (CD) in Iran. Background: The assessment of burden of CD has become an important primary or secondary outcome measure in clinical and epidemiologic studies. Methods: Information regarding medical costs and gluten free diet (GFD) costs were gathered using questionnaire and checklists offered to the selected patients with CD. The data included the direct medical cost (including Doctor Visit, hospitalization, clinical test examinations, endoscopies, etc...
2017: Gastroenterology and Hepatology From Bed to Bench
Mohamad Amin Pourhoseingholi, Sara Ashtari, Nastaran Hajizadeh, Zeinab Fazeli, Mohammad Reza Zali
Pancreatic cancer is one of the deadliest cancers with short-term survival rates. Trends for pancreatic cancer incidence and mortality varied considerably in the world. To date, the causes of pancreatic cancer are not known sufficiently, although certain risk factors have been identified such as, smoking, obesity, life style, diabetes mellitus, alcohol, dietary factors and chronic pancreatitis. Since there are no current screening recommendations for pancreatic cancer, primary prevention is very important. Therefore, up-to-date statistics on pancreatic cancer occurrence and outcome are essential for the primary prevention of this disease...
2017: Gastroenterology and Hepatology From Bed to Bench
Genel Sur, Lucia Sur, Anamaria Girbovan, Gabriel Samasca, Giulia Alexandru, Rahela Carpa, Iulia Lupan
No abstract text is available yet for this article.
2017: Gastroenterology and Hepatology From Bed to Bench
Roya Salehi, Ali Haghighi, C Rune Stensvold, Farnaz Kheirandish, Eznelloah Azargashb, Saber Raeghi, Cobra Kohansal, Fares Bahrami
Aim: The aim of the present study was to determine the prevalence and subtype distribution of Blastocystis and its relation with demographic data and symptoms in humans referred to medical centers in Ahvaz 2014-2015. Background: Infections with intestinal parasites are one of the most important threats to human health worldwide, especially in tropical and subtropical areas. Blastocystis sp. is a common parasite of humans with a vast variety of non-human hosts. We aimed to study the prevalence and subtypes of Blastocystis sp...
2017: Gastroenterology and Hepatology From Bed to Bench
Ebrahim Rezazadeh Zarandi, Shahla Mansouri, Nouzar Nakhaee, Farhad Sarafzadeh, Zahra Iranmanesh, Mohammad Moradi
Aim: This study evaluated the frequency of C. difficile and CDAD in the ICU of Shahid Bahonhar Hospital, Kerman, Iran. Background: Clostridium difficile (C. difficile) is the most important antibiotic associated diarrhea agent in intensive care unit (ICU) patients. Based on its toxin producing ability, C .difficile is divided to toxigenic and non-toxigenic strains. Methods: A total of 233 diarrheal samples were collected from ICU patients...
2017: Gastroenterology and Hepatology From Bed to Bench
Peter Lokamar Nyanga, Jackson Onyuka, Mark Kilongosi Webale, Tom Were, Valentine Budambula
Aim: In the present study, we investigated the prevalence of E. coli pathotypes and Shigella sero-groups and their antimicrobial profiles among diarrheic children in Nairobi city, Kenya. Background: Although diarrheagenic E. coli pathotypes and Shigella sero-groups are leading causes of diarrhea in children under five years in developing countries, their distribution and antimicrobial resistance vary from place to place and over time in a given region. Methods: In a cross-sectional study, we enrolled diarrheic children (n=354) under five years seeking treatment at Mbagathi Hospital, Nairobi city, Kenya,...
2017: Gastroenterology and Hepatology From Bed to Bench
Shaghayegh Baradaran Ghavami, Vahid Chaleshi, Shaghayegh Derakhshani, Pedram Aimzadeh, Hamid Asadzadeh-Aghdaie, Mohammad Reza Zali
Aim: The aim of this study was to find the relationship between rs1799964 in TNF-α gene as well as rs1051208 of RAF1 gene SNPs on GC in an Iranian population. Background: Gastric cancer (GC) is the second leading cause of cancer-related death worldwide after lung cancer. Tumor necrosis factor (TNF) is one of the most important factors in the pathogenesis of this cancer. Single nucleotide polymorphisms have a principle role in gene expression of TNF-α and miRNAs which may lead to gastric cancer...
2017: Gastroenterology and Hepatology From Bed to Bench
Kaveh Baghaei, Seyed Mohmoud Hashemi, Samaneh Tokhanbigli, Ali Asadi Rad, Hamid Assadzadeh-Aghdaei, Abdolhamid Sharifian, Mohammad Reza Zali
Aim: We describe the minimum requirements and a simplified method for isolation and characterization of mesenchymal stem cells (MSCs) from human bone marrow. Background: MSCs are well known adult stem cells present in many tissues such as adipocytes, chondrocytes, osteoblasts, and neurons. Many isolations and characterization methods have emerged to apply MSCs in the clinical applications, which many of them are expensive and time-consuming. Methods: MSC isolation was carried out from human bone marrow, and cultured in defined medium...
2017: Gastroenterology and Hepatology From Bed to Bench
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