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International Journal of Hematology-oncology and Stem Cell Research

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https://www.readbyqxmd.com/read/27489595/clavicular-chondrosarcoma-a-case-report-and-brief-review-of-the-literature
#1
Ali Ghorbani Abdehgah, Behnam Molavi, Saeed Reza Mehrpour, Amir Reza Radmard, Mohammad Mahjori, Nasser Kamalian, Hosein Kamranzadeh
Clavicular bone tumors occur in less than 0.5 percent of bone tumors. Primary chondrosarcoma is very rare even among clavicle tumors. The main symptom is a touchable mass in 69 % of patients. Dedicated centers using FNA and cytology can reach a correct diagnosis in 94% of cases. Treatment planning is done using simple X-ray, CT-scan, shoulder MRI, chest CT-scan and whole body technetium scan. Treatment of choice for primary chondrosarcoma of clavicle is surgical resection.
July 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27489594/difficult-diagnosis-of-colon-adenocarcinoma-metastasis-to-retina-a-case-report-and-literature-review
#2
Ratnam Nookala, Vera V Batchu, Heather M Lee, Amir Loghmani, Gurdeep S Chhabra
Intraocular metastatic tumors have been increasingly reported in the recent past. Unlike choroidal metastasis, metastasis to retina is very rare and so far has been reported in very few case reports only. A 56 year-old male who presented with a history of adenocarcinoma of the cecum and underwent lap colectomy for the primary cecal tumor, received adjuvant chemotherapy for a year after surgery and decided to stop. He was also diagnosed with metastasis to liver and lung at this time. He presented with left eye pain, pressure and decreased vision suspicious for retinal metastasis from cecal primary lesion, 2 years after initial diagnosis...
July 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27489593/the-role-of-micrornas-in-myeloproliferative-neoplasia
#3
REVIEW
Shaban Alizadeh, Seyed Ghader Azizi, Masoud Soleimani, Yadollah Farshi, Zahra Kashani Khatib
MiRs are 17-25 nucleotide non-coding RNAs. These RNAs target approximately 80% of protein coding mRNAs. MiRs control gene expression and altered expression of them affects the development of cancer. MiRs can function as tumor suppressor via down-regulation of proto-oncogenes and may function as oncogenes by suppressing tumor suppressors. Myeloproliferative neoplasias (formerly known as chronic myeloproliferative disorders) form a class of hematologic malignancies demonstrating the expansion of stem cells in one or more hematopoietic cell lines...
July 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27489592/human-platelet-lysate-as-a-xeno-free-alternative-of-fetal-bovine-serum-for-the-in-vitro-expansion-of-human-mesenchymal-stromal-cells
#4
Saeed Mohammadi, Mohsen Nikbakht, Ashraf Malek Mohammadi, Mahdi Zahed Panah, Mohammad Reza Ostadali, Hajar Nasiri, Ardeshir Ghavamzadeh
BACKGROUND: Mesenchymal stromal cells (MSCs) are employed in various different clinical settings in order to modulate immune response. Human autologous and allogeneic supplements including platelet derivatives such as platelet lysate (PL), platelet-released factors (PRF) and serum are assessed in clinical studies to replace fetal bovine serum (FBS). The immunosuppressive activity and multi-potential characteristic of MSCs appear to be maintained when the cells are expanded in platelet derivatives...
July 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27489591/evaluation-of-bone-mineral-density-in-children-with-acute-lymphoblastic-leukemia-all-and-non-hodgkin-s-lymphoma-nhl-chemotherapy-with-without-radiotherapy
#5
Ali Ghassemi, Abdollah Banihashem, Nosrate Ghaemi, Saghi Elmi, Reza Erfani Sayyar, Sam Elmi, Habibollah Esmaeili
BACKGROUND: Acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL) are the most common malignancies in children and adolescents. Therapies such as corticosteroids, cytotoxic and radiotherapy will have harmful effect on bone mineral density (BMD) which can lead to increased possibility of osteoporosis and pathological fractures. SUBJECTS AND METHODS: This 3-year cross-sectional study was performed in 50 children with ALL (n=25) and NHL (n=25) at Dr. Sheikh Children's Hospital in Mashhad...
July 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27489590/evaluation-of-minimal-residual-disease-in-acute-myeloid-leukemia-with-npm1-marker
#6
Nasrin Alizad Ghandforoush, Bahram Chahardouli, Shahrbano Rostami, Habibeh Ghadimi, Ali Ghasemi, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Fatemeh Nadali
BACKGROUND: Minimal residual disease (MRD) tests provide early identification of hematologic relapse and timely management of acute myeloid leukemia (AML) patients. Approximately, 50% of AML patients do not have clonal chromosomal aberrations and categorize as a cytogenetically normal acute myeloid leukemia (CN-AML). About 60% of adult CN-AML has a mutation in exon 12 of NPM1 gene. This mutation is specific for malignant clone and potentially is a good marker of MRD. In this retrospective study, we set up a quantitative test for quantifying NPM1 type A mutation and AML patients carrying this mutation at the time of diagnosis, were followed-up...
July 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27489589/diagnosis-and-classification-of-acute-leukemia-in-bone-marrow-trephine-biopsies-utility-of-a-selected-panel-of-minimal-immunohistochemical-markers
#7
Priya Subashchandrabose, Lakshmikanth Ramiah Madanagopaal, Tadury Madhukar Subba Rao
BACKGROUND: Acute leukemias are characterized by neoplastic proliferation of hematopoietic stem cells and accumulation of blasts and immature cells in bone marrow. We applied a selective panel of immunohistochemical markers on bone marrow trephine tissue sections and observed their utility in diagnosis and typing of acute leukemia. MATERIALS AND METHODS: The study was done at PSG Institute of Medical Sciences and Research from 1st January, 2008 to 30th June, 2012...
July 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27489588/association-between-methylenetetrahydrofolate-reductase-mthfr-gene-polymorphisms-and-susceptibility-to-childhood-acute-lymphoblastic-leukemia-in-an-iranian-population
#8
Gholamreza Bahari, Mohammad Hashemi, Majid Naderi, Mohsen Taheri
BACKGROUND: The present study was aimed to examine the possible association between methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms and childhood acute lymphoblastic leukemia (ALL) in a sample of Iranian population. SUBJECTS AND METHODS: A total of 220 subjects including 100 children diagnosed with ALL and 120 healthy children participated in the case-control study. The single nucleotide polymorphisms (SNPs) of MTHFR were determined by ARMS-PCR or PCR-RFLP method...
July 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27489587/curcumin-veto-the-effects-of-osteopontin-opn-specific-inhibitor-on-leukemic-stem-cell-colony-forming-potential-via-promotion-of-opn-overexpression
#9
Saeed Mohammadi, Seyed H Ghaffari, Mojgan Shaiegan, Mahin Nikogoftar Zarif, Mohsen Nikbakht, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
BACKGROUND: Acute myeloid leukemia (AML) is an immunophenotypically heterogeneous malignant disease, in which CD34 positivity is associated with poor prognosis. Osteopontin (OPN) plays different roles in physiologic and pathologic conditions like: survival, metastasis and cell protection from cytotoxic and apoptotic stimuli. Due to anti-apoptotic effect of OPN in normal and malignant cells, silencing of OPN leads to elevation of sensitivity towards chemotherapeutic agents and attenuates cancer cells migration and invasion...
July 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27252813/approach-to-the-triple-negative-breast-cancer-in-new-drugs-area
#10
REVIEW
Mehrzad Mirzania
Triple negative breast cancers (TNBCs) are associated with aggressive course, higher rates of visceral and central nervous system metastases and lower survival rate than hormone receptor positive. Once metastasis has occurred, a median survival was approximately one year. Currently, chemotherapy in TNBC is similar to other HER2- negative breast cancers but in the near future, it will revolutionize. TNBCs are quite heterogeneous based on biomarkers and genetic variations. The series of new drugs have been tried; in this article, platinum, anti-epigenetic drugs, PARP inhibitors, epidermal growth factor receptor inhibitor, Src family kinase inhibitor, anti androgen, glycoprotein Non-metastatic melanoma B (gpNMB) antibody, LHRH conjugated to cytotoxic drugs and inhibition of the PI3K/AKT/mTOR pathway will be explained...
April 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27252812/a-case-of-multiple-myeloma-following-bladder-cancer
#11
Hamid Shafi, Mohsen Vakili Sadeghi, Hosein Ghorbani, Majid Sharbatdaran
Second primary malignancy following multiple myeloma (MM) was reported several years ago. There are also rare reports of cases with synchronous MM and other malignancies. To our knowledge, only one case of MM following bladder cancer has been reported in the literature. Here, we report the second case occurred three months after diagnosis of bladder cancer.
April 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27252811/bilateral-maxillary-sphenoid-sinuses-and-lumbosacral-spinal-cord-extramedullary-relapse-of-cml-following-allogeneic-stem-cell-transplant
#12
Soudabeh Hosseini, Shahla Ansari, Parvaneh Vosough, Gholamreza Bahoush, Amir Ali Hamidieh, Bahram Chahardouli, Morteza Shamsizadeh, Mitra Mehrazma, Akbar Dorgalaleh
Isolated extramedullary relapse of chronic myelogenous leukemia (CML) after allogeneic stem cell transplant is rare. There is a case report of a child who developed a granulocytic sarcoma of the maxillary and sphenoid sinuses and lumbosacral spinal cord mass 18 months after allogeneic bone marrow transplant for CML. He was presented with per orbital edema and neurological deficit of lower extremities and a mass lesion was found on spinal cord imaging. No evidence of hematologic relapse was identified at that time by bone marrow histology or cytogenetic...
April 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27252810/in-vitro-effects-of-propranolol-on-t-helper-type-1-cytokine-profile-in-human-leukemic-t-cells
#13
Fatemeh Hajighasemi, Abbas Mirshafiey
INTRODUCTION: Cytokines are a large group of proteins play a key role in inflammation. Down-regulation of pro-inflammatory cytokines has beneficial effect on heart function. Propranolol, as a non selective beta-adrenergic blocker, has been extensively used for treatment of many cardiovascular problems such as arrhythmias and heart malfunction. In addition anti-inflammatory effects of propranolol have been revealed. In this study the propranolol effect on T helper type 1 cytokine profile in human leukemic T cells has been assessed in vitro...
April 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27252809/clinical-manifestations-of-%C3%AE-thalassemia-major-in-two-different-altitudes-bushehr-and-shahrekord
#14
Mohammad Reza Ravanbod, Ali Movahed, Afshin Ostovar, Ali Hajigholami, Gholamreza Khamisipour, Shokrollah Farrokhi, Hossein Darabi, Yasaman Khosravi, Mohammad Kazzem Gheybi
BACKGROUND: Patients with β-thalassemia major (TM) develop iron overload through increased iron absorption and transfusional therapy and it's the most important complication of TM. Thalassemia is common in coastal regions and lands with low altitudes. The aim of this study is to determine the effect of high and low altitude on serum ferritin and treatment requirement in two groups of β-thalassemia major (TM) patients. SUBJECTS AND METHODS: Patients were divided into two groups, the first group (No: 50) living at sea level (in the port of Bushehr, Iran) and the second group (No: 40) living at the altitude of 2061 m (in the city of Shahrekord, Iran)...
April 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27252808/granulocyte-colony-stimulating-factor-use-in-a-large-iranian-hospital-comparison-with-american-society-of-clinical-oncology-asco-clinical-practice-guideline
#15
Sarah Mousavi, Mina Dadpoor, Farzaneh Ashrafi
BACKGROUND: Granulocyte Colony Stimulating Factors (GCSF) is high-cost agents commonly recommended for primary and secondary prophylaxis of chemotherapy-induced neutropenia and febrile neutropenia. GCSFs have been shown to be beneficial in some patient subgroups, although they are probably overused in clinical settings. The American Society of Clinical Oncology (ASCO) guidelines summarize current data on the appropriate use of CSFs. The aim of this study was to assess and audit the use of GCSF in a tertiary care center according to the recommendation of ASCO guideline...
April 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27252807/the-relationship-between-self-esteem-and-quality-of-life-of-patients-with-idiopathic-thrombocytopenic-purpura-at-isfahan-s-sayed-al-shohada-hospital-iran-in-2013
#16
Zeinab Hemati, Davood Kiani
BACKGROUND: Idiopathic thrombocytopenic purpura (ITP) is a chronic disease which is accompanied with hopelessness and loss of the sense of well-being due to its symptoms and treatment. It also affects patients' sense of social and spiritual well-being. This disorder decreases patients' self-esteem and their quality of life by changing their mental image and self-confidence. This study was performed to find the relationship between self-esteem and quality of life of patients with ITP. SUBJECTS AND METHODS: This was a descriptive-analytical study on 64 patients with ITP who referred to Isfahan's Sayed Al-Shohada Hospital, Iran...
April 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27252806/jak2v617f-allele-burden-measurement-in-peripheral-blood-of-iranian-patients-with-myeloproliferative-neoplasms-and-effect-of-hydroxyurea-on-jak2v617f-allele-burden
#17
Shirin Ferdowsi, Seyed H Ghaffari, Naser Amirizadeh, Azita Azarkeivan, Kamran Atarodi, Mohammad Faranoush, Gholamreza Toogeh, Reza Shirkoohi, Mohammad Vaezi, Mahtab Maghsoodlu, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Hosein Teimori Naghadeh
BACKGROUND: Myeloproliferative neoplasms (MPNs) are clonal malignant diseases that represent a group of conditions including polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). The aim of this study was to evaluate possible correlations between JAK2V617F allele burden and clinicohematologic characteristics in Iranian patients with MPNs. We also aimed at determining the correlation between JAK2V617F allele burden and use of cyto reductive treatment (hydroxyurea)...
April 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27252805/microbial-and-antibiotic-susceptibility-profile-among-clinical-samples-of-patients-with-acute-leukemia
#18
Alireza Abdollahi, Faezeh Hakimi, Mahsa Doomanlou, Azadeh Azadegan
INTRODUCTION: Preventing and starting early treatment of infections in patients whose immunity system is weak due to malignancies like leukemia can reduce mortality. This study aimed to determine microbial and antibiotic resistance patterns in clinical samples of patients with acute leukemia to start early treatment before the results of clinical tests are known. SUBJECTS AND METHODS: In this cross-sectional study, the clinical samples of all patients hospitalized with the diagnosis of acute leukemia were cultured and their antibiogram was evaluated...
April 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27047652/a-patient-with-multiple-myeloma-and-renal-cell-carcinoma
#19
Farhad Shahi, Marziye Ghalamkari, Mehrzad Mirzania, Mahdi Khatuni
The coexistence of two malignancies is rarely seen. A little association between hematologic malignancies especially multiple myeloma and renal cell carcinoma has been reported in the recent past. Several case series revealed a bidirectional association between these two malignancies which may be due to the common risk factors, similar cytokine growth requirements and clinical presentation. Here, we aim to describe a patient who had multiple myeloma and in his work up renal cell carcinoma was found out incidentally...
January 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27047651/case-report-of-metastatic-invasive-breast-lobular-carcinoma-to-the-urinary-bladder
#20
Ahmed A Al Ibraheemi
Breast cancer is the most common cancer in women except skin cancer. The common metastatic sites include lymph node, lung, liver and bone. However, metastasis to the bladder is extremely rare. To our knowledge, this is the first case of breast cancer metastasis to urinary bladder in Jordan which is reported. Nine years after the initial diagnosis of lobular breast carcinoma, the patient suffered from left side leg edema; Ultrasonography and Computed tomography scanning showed thickening of posterior bladder wall and bilateral hydronephrosis...
January 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
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