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International Journal of Hematology-oncology and Stem Cell Research

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https://www.readbyqxmd.com/read/29951181/predictors-and-correlates-of-fatigue-in-sickle-cell-disease-patients
#1
Mehrnaz Ahmadi, Saeed Poormansouri, Samira Beiranvand, Ladan Sedighie
Background: Although fatigue is the most important symptom of Sickle Cell Disease, the extent of it is unknown, and causal mechanisms are not well understood. This article explores biopsychosocial characteristics that can potentially contribute to fatigue in SCD. Materials and Methods: This cross-sectional, correlational study included 97 SCD patients who aged over 16 years and had records in Thalassemia Ward and Clinic of Shafa Hospital affiliated to Ahvaz University of Medical Sciences, Ahvaz, Iran. Data were collected from a self- reported demographic questionnaire, measuring depression, anxiety stress scale (DASS-21) and fatigue severity scale (FSS)...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951180/clear-cell-sarcoma-a-case-report-and-review-of-literature
#2
Alireza Abdollahi, Fatemeh Khatami, Seyed Mohammad Tavangar
Clear cell sarcoma (CCS), a deep-rooted tumor with a predilection for lower extremities, has a proclivity to involve the tendons and aponeuroses. This sarcoma is seen predominantly around the foot and ankle region. Diagnosis is mainly finalized using histological and immunohistochemical assessment. The main treatment strategy is surgery followed by chemotherapy. An erratic challenge is posed by histological similarity and immunohistochemical overlap to the diagnosis and distinguishing of clear cell sarcoma from primary or metastatic malignant melanoma (MM) which is more common...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951179/assessing-prognostic-factors-in-hodgkin-s-lymphoma-multistate-illness-death-model
#3
Fatemeh Javanmardi, Amal Saki-Malehi, Ahmad Ahmadzadeh, Fakher Rahim
Background: Hodgkin's lymphoma (HL) is a unique cancer of lymphocytes that has unknown reason. As lymphocytes are found throughout the lymphatic system, HL can start almost anywhere in the body. It usually starts in a group of lymph nodes in one part of the body; it usually spreads in a predictable form, from one group of lymph nodes to the next. Eventually, it can spread to almost any tissue or organ in the body through the lymphatic system or the bloodstream. So it's important to evaluate the prognostic factors of mortality and recurrence...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951178/association-between-gt-n-repeats-in-heme-oxygenase-1-gene-promoter-and-3-year-survival-of-patients-with-acute-leukemia-a-controlled-cross-sectional-study
#4
Mohammad Kazemi, Farinaz Khosravian, Amir Abbas Sameti, Alireza Moafi, Mohammad Reza Merasi, Mansour Salehi, Majid Nejati, Mohaddeseh Behjati
Background: Acute leukemia is a common pediatric cancer. Novel strategies for treatment of acute leukemia have been developed, but treatment resistance is remained as the most problematic issue. It is hypothesized that the HO-1 gene up-regulation is responsible for tumor resistance to chemotherapy or radiotherapy-induced apoptosis. The levels of HO-1 expression are related to (GT)n microsatellite polymorphisms in the location of its promoter. This study designed to compare allelic frequencies of (GT)n microsatellite polymorphisms in HO-1 gene between acute leukemia patients and healthy controls...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951177/study-of-the-relationship-between-hpa-1-and-hpa-5-gene-polymorphisms-and-refractory-to-platelet-therapy-and-recombinant-factor-vii-in-glanzmann-thrombasthenia-patients-in-southeast-of-iran
#5
Majid Naderi, Manizheh Habibpour, Shaban Alizadeh, Zahra Kashani Khatib, Akbar Dorgalaleh, Mohammed Awal Issah, Fatemeh Naadali
Background: Glanzmann Thrombasthenia (GT) is a rare autosomal disease. HPA (Human Platelet Alloantigen) is a surface polymorphic alloantigen of platelets. This study was intended to investigate and compare the polymorphism of HPA-1 and HPA-5 genes in two groups of GT patients, with and without resistance to platelet and recombinant factor VII therapy. Materials and Methods: This case control study was performed on GT patients (n=16) with resistance to platelet therapy and recombinant factor VII and control group of GT patients (n=16) without resistance to platelet therapy and recombinant factor VII...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951176/comparative-evaluation-of-biochemical-and-hematological-parameters-of-pre-storage-leukoreduction-during-rbc-storage
#6
Behrooz Ghezelbash, Azita Azarkeivan, Ali Akbar Pourfathollah, Mohammadreza Deyhim, Esmerdis Hajati, Alireza Goodarzi
Background: Some of the red cell storage lesions (RCSLs) take place during red blood cell (RBC) storage and may reduce the function of these cells dramatically, which mostly caused by residual leucocytes in blood components. This study was planned to observe the biochemical and hematological changes in pre-storage leukoreduced RBC (LR-RBC) compared with unfiltered RBC during in vitro storage. Materials and Methods: Ten unit RBCs were collected, processed and stored according to Iranian standard operating procedure (SOP) of Iranian Blood Transfusion Organization (IBTO)...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951175/utility-of-a-single-tube-six-color-flow-cytometry-panel-for-the-diagnosis-of-myelodysplastic-syndrome-experience-of-a-tertiary-care-centre-in-india
#7
R Gupta, K Rahman, M K Singh, S Kumari, G Yadav, S Nityanand
Background: Diagnosis of myelodysplastic syndromes (MDS) is challenging in the presence of morphological mimickers. Flow cytometric immunophenotyping (FCI) has been added to the diagnostic armamentarium, but its use in clinical practice is variable. Materials and Methods: Bone marrow aspirate samples from 54 patients with a clinical and/or morphological suspicion of MDS were subjected to FCI using a single-tube, 6-colour panel comprising of monoclonal antibodies against CD13, CD11b, CD16, CD34, CD45 and CD56...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951174/pattern-of-kebab-intake-as-a-potential-carcinogenic-risk-factor-in-adults-of-kermanshah-iran-2015
#8
Seyyed Mostafa Nachvak, Mahboobe Hosseinikia, Hadi Abdollahzad, Yahya Pasdar, Farhad Oubari, Roghaye Hosseinikia, Maryam Shabanpur
Background: Epidemiologic studies indicated that dietary pattern plays a determinant role in cancer incidence. They also indicated that 1/3 of cancers are associated to foods. Diet contains different carcinogenic agents: naturally occurring chemicals, synthetic components and compounds produced during cooking such as kebab. This traditional food is one of the most popular foods in the Middle East, particularly in Iran. Red meat, especially lamb or veal, is the most common meat used in preparation of kebab. Since kebab is considered as a food containing carcinogenic compounds, so the purpose of this study was to assess the consumption pattern of kebab in a sample of Iranian adults and its relationship with demographic characteristics...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951173/association-between-altered-expression-and-genetic-variations-of-transforming-growth-factor-%C3%AE-smad-pathway-with-chronic-myeloid-leukemia
#9
Yogender Shokeen, Neeta Raj Sharma, Abhishek Vats, Veronique Dinand, Mirza Adil Beg, Satish Sanskaran, Sachin Minhas, Mayank Jauhri, Arun K Hariharan, Vibha Taneja, Shyam Aggarwal
Background: Chronic myeloid leukemia (CML) is a hematological disorder caused by fusion of BCR and ABL genes. BCR-ABL dependent and independent pathways play equally important role in CML. TGFβ-Smad pathway, an important BCR -ABL independent pathway, has scarce data in CML. Present study investigate the association between TGFβ-Smad pathway and CML. Materials and Methods: Sixty-four CML patients and age matched healthy controls (n=63) were enrolled in this study. Patients were segregated into responder and resistant groups depending on their response to Imatinib mesylate (IM)...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951172/multiple-cranial-nerve-palsy-concomitant-with-leptomeningeal-involvement-in-multiple-myeloma-a-case-report-and-review-of-literature
#10
Neda Pak, Fatemeh Shakki Katouli, Amir Reza Radmard, Mohammad Hassan Shaki Katuli, Mohamad Mehdi Rezwanifar, Negar Sepehri Boroujeni
Neurologic symptoms are quite common in multiple myeloma, but direct invasion of central nervous system is extremely rare. Leptomeningeal multiple myeloma, as a rare neurological manifestation of multiple myeloma, presents with impairment of consciousness, cranial nerve palsies and convulsions. Here, we describe a 52-year- old male patient, known case of multiple myeloma, who presented with bilateral visual loss and difficulty in swallowing.
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951171/a-study-on-the-clinical-outcome-of-abiraterone-acetate-in-castration-resistant-prostate-cancer-patients
#11
Aloysius James, Bini Vincent, Akhila Sivadas, K Pavithran
Background: Abiraterone acetate was approved by FDA and EMA in April and September 2011, respectively for treatment of patients with casteration resistant prostate cancer and those previously treated with docetaxel. It is a selective inhibitor of androgen biosynthesis which potentially and irreversibly blocks CYP17, a crucial enzyme in oestrogen and testosterone synthesis. Materials and Methods: This retrospective study was conducted to evaluate the safety and efficacy of abiraterone acetate in the treatment of castration resistant prostate cancer patients...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951170/serpentine-supravenous-hyperpigmentation-in-an-hiv-patient-receiving-r-chop-for-dlbcl
#12
Guido Lancman, Amir Steinberg, Janice Gabrilove
Serpentine supravenous hyperpigmentation (SSH) is a rare vasculo-cutaneous entity that has been associated with peripheral infusion of chemotherapy agents, in particular 5-FU1 - 3 , but also seen with docetaxel4 , 5 , fotemustine6 , and vinorelbine7 . It consists of a marked hyperpigmentation along the superficial network of veins proximal to the chemotherapy infusion site and was originally described in a 1976 case report in association with 5-FU1 . Here, for the first time, we report SSH in association with R-CHOP chemotherapy...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29340131/acute-myeloid-leukemia-genetic-alterations-and-their-clinical-prognosis
#13
REVIEW
Francisco Alejandro Lagunas-Rangel, Venice Chávez-Valencia, Miguel Ángel Gómez-Guijosa, Carlos Cortes-Penagos
Acute myeloid leukemia (AML) is a group of hematological diseases, phenotypic and genetically heterogeneous, characterized by abnormal accumulation of blast cells in the bone marrows and peripheral blood. Its incidence rate is approximately 1.5 per 100,000 in infants younger than 1 year of age and 25 per 100,000 persons in octogenarians. Traditionally, cytogenetic markers are used to stratify patients in three risk categories: favorable, intermediate and unfavorable. However, the forecast stratification and the treatment decision for patients with normal karyotype shows difficulties due to the high clinical heterogeneity...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29340130/mechanism-action-of-platelets-and-crucial-blood-coagulation-pathways-in-hemostasis
#14
REVIEW
Mercy Halleluyah Periayah, Ahmad Sukari Halim, Arman Zaharil Mat Saad
Blood is considered to be precious because it is the basic necessity for health; our body needs a steady provision of oxygen, supplied via blood, to reach billions of tissues and cells. Hematopoiesis is the process that generates blood cells of all lineages. However, platelets are the smallest blood component produced from the very large bone marrow cells called megakaryocytes and they play a fundamental role in thrombosis and hemostasis. Platelets contribute their hemostatic capacity via adhesion, activation and aggregation, which are triggered upon tissue injury, and these actions stimulate the coagulation factors and other mediators to achieve hemostasis...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29340129/protective-isolation-for-patients-with-haematological-malignancies-a-pilot-study-investigating-patients-distress-and-use-of-time
#15
O Annibali, C Pensieri, V Tomarchio, V Biagioli, M Pennacchini, A Tendas, V Tambone, M C Tirindelli
Background: Patients with haematological malignancies are often hospitalized in protective isolation until full neutrophil recovery in order to prevent infections. This descriptive pilot study evaluate the level of isolation-related distress and the use of free time in a sample of Italian onco-haematological patients who were hospitalized in protective isolation. Materials and Methods: Participants were 18 patients hospitalized in hematologic ward to receive induction therapy (n=12) or autologous stem cell transplant (n=6)...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29340128/hematological-reference-intervals-for-healthy-iranian-blood-donors
#16
Mahboubeh Rasouli, Mojgan Pourmokhtar, Shaghayegh Sarkardeh
Background: Development of locally-derived hematological reference intervals is necessary for improving the quality of health care and clinical trials. However hematological reference intervals are affected by several variables including age, gender and environmental factors. Therefore this study was conducted to determine the gender and age-specific hematological reference intervals of healthy Iranian blood donors. Materials and Methods: Selected hematological indices of 394 healthy blood donor volunteers, donating blood at Tehran Blood Transfusion Center were analyzed...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29340127/restarting-thalidomide-dexamethasone-regimen-in-a-post-abortive-female-with-multiple-myeloma-effective-clinical-response-possible
#17
Suhailur Rehman, S H Arif, Amit Kumar, A Q Khan
Nowadays, the prevalence of Multiple Myeloma (MM) seems to have been increasing among young females. Here, we report that thalidomide is contraindicated in pregnant women diagnosed with MM and those desirous of subsequent pregnancy. In this case report, we compared the clinical response of Thalidomide-Dexamethasone therapy in a post-abortive woman with persistently elevated β-hCG levels due to retained products of conception, undergoing hysterectomy later. This case report underlines the clinical significance of age, the effect of Thalidomide-Dexamethasone therapy even after initial discontinuation and the response to high β-hCG levels...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29340126/hepatosplenic-gamma-delta-t-cell-lymphoma-hsgdtcl-two-rare-case-reports-from-western-india
#18
Irappa Madabhavi, Gaurang Modi, Harsha Panchal, Apurva Patel, Swaroop Revannasiddaiah, Asha Anand, Sonia Parikh, Kshitij Joshi, Malay Sarkar
Peripheral T cell lymphomas are a heterogeneous group of post-thymic, mature lymphoid malignancies, accounting for approximately 10-15% of all non-Hodgkin's lymphomas. Hepatosplenic T-cell lymphoma (HSGDTCL) is a rare entity, which is characterized by primary extra nodal disease with typical sinusoidal or sinusal infiltration of the liver and the spleen, respectively by expression of the T-cell receptor γδ chain, and by a number of other frequent clinicopathologic features, including aggressive course of disease...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29340125/rare-presentation-of-refractory-thrombotic-thrombocytopenic-purpura-jejunal-stricture
#19
Prabath K Abeysundara, Inoshi Athukorala, K P C Dalpatadu, Karthiha Balendran, M D S A Dilrukshi, Gmo Fernando
Thrombotic thrombocytopenic purpura is a rare thrombotic disease characterized by episodes of thrombocytopenia and microangiopathic hemolytic anemia due to disseminated microvascular thrombosis. Thrombotic thrombocytopenic purpura was first described in 1924 by Moschowitz as a disease presenting with a pentad of signs and symptoms (anemia, thrombocytopenia, fever, hemiparesis and hematuria). Previous studies have described atypical manifestations of thrombotic thrombocytopenic purpura such as hemolysis, anemia and thrombosis...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29340124/the-use-of-filgrastim-in-patients-with-hodgkin-lymphoma-receiving-abvd
#20
Adam F Binder, Sonia Rai, Amir Steinberg
Background: There is conflicting data about the increased risk of pulmonary toxicity when granulocyte-stimulating factor (G-CSF) is given in combination with bleomycin. No clear consensus for management of patients with Hodgkin lymphoma (HL) who require G-CSF support exists. Our objective was to evaluate whether there is an increase in pulmonary toxicity in patients who receive bleomycin and G-CSF during treatment for HL. Materials and Methods: We conducted a single-center retrospective analysis of patients with Hodgkin Lymphoma from January 2003 until July 2015...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
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