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International Journal of Hematology-oncology and Stem Cell Research

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https://www.readbyqxmd.com/read/30233778/role-of-hippo-pathway-effector-tafazzin-protein-in-maintaining-stemness-of-umbilical-cord-derived-mesenchymal-stem-cells-uc-msc
#1
Madhumala Gopinath, Rosa Di Liddo, Francesco Marotta, Ramachandran Murugesan, Antara Banerjee, Sushmitha Sriramulu, Ganesan Jothimani, Vimala Devi Subramaniam, Srinivasan Narasimhan, Swarna Priya K, Xiao-Feng Sun, Surajit Pathak
Tafazzin (TAZ) protein has been upregulated in various types of human cancers, although the basis for elevation is uncertain, it has been made definite that the effect of mutation in the hippo pathway, particularly when it is switched off, considerably activates tafazzin transcriptionally and thus this results in tissue or tumor overgrowth. Recent perceptions into the activity of tafazzin, have ascribed to it, a role as stem cell factor in mouse mesenchymal and as well as in neural stem cells. Being a downstream molecule in Hippo signalling, phosphorylation or dephosphorylation of tafazzin gene regulates its transcriptional activity and the stemness of mesenchymal stem cells...
April 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/30233777/factors-affecting-the-incidence-and-severity-of-oral-mucositis-following-hematopoietic-stem-cell-transplantation
#2
Maryam Valeh, Mona Kargar, Ava Mansouri, Hosein Kamranzadeh, Kheirollah Gholami, Kazem Heidari, Moluk Hajibabaei
Background: Patients who receive hematopoietic stem cell transplantation (HSCT) experience several complications that oral mucositis (OM) is a frequent symptom. This study was designed to evaluate the incidence, risk factors, prophylaxis and treatment strategies for established OM. Materials and Methods: We included 173 adult patients who received autologous or allogeneic hematopoietic stem cell transplantation in this study. The World Health Organization oral toxicity scale was used to assess the severity of OM...
April 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/30233776/bevacizumab-inhibits-angiogenic-cytokines-in-head-and-neck-squamous-cell-carcinoma-from-gene-to-the-protein
#3
Hossein Heydar, Kamran Mansouri, Maryam Norooznezhad, Fatemeh Norooznezhad, Abdolreza Mohamadnia, Naghmeh Bahrami
Background: Head and neck squamous cell carcinoma (HNSCC) is one most prevalent cancers among worldwide. Aim of this study was to evaluate possible effect of bevacizumab, a vascular endothelial growth (VEGF) factor monoclonal antibody on HNSCC cells in vitro to evaluate angiogenic profile changes. Materials and Methods: HNSCC cells were grown and after that different concentrations of bevacizumab were added in order to evaluate cytotoxic concentration using MTT assay. Then after, the cultured cells in presence of different concentration of bevacizumab were evaluated for gene expression of VEGF, matrix metalloprotease-2 (MMP-2) and MMP-9 using real time polymerase chain reaction (PCR)...
April 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/30233775/t-cell-prolymphocytic-leukemia-an-experience-from-a-tertiary-cancer-centre-in-south-india
#4
Suresh Babu Mc, Abhishek Anand, Kuntegowdanahalli C Lakshmaiah, Govind Babu K, Dasappa Lokanatha, Linu Abraham Jacob, D S Madhumathi, Kadabur N Lokesh, A H Rudresha, L K Rajeev, Rajesh Patidar
Background: T-cell prolymphocytic leukemia (T-PLL) is a rare lymphoid malignancy with dismal prognosis. Most patients have increased lymphocyte count (>1,00,000/dL) and widespread disease at presentation. Despite high response rate seen with alemtuzumab, the disease relapse is inevitable. Materials and Methods : This was a retrospective observational study done at a tertiary cancer center in South India. All patients diagnosed with T-PLL from August 2010 to July 2015 were studied for the clinical characteristics, pathological findings and treatment outcomes...
April 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/30233774/the-confirmation-of-safety-for-the-intensified-conditioning-regimens-a-retrospective-study-of-allogeneic-hematopoietic-stem-cell-transplantation-for-non-remission-hematological-malignant-diseases
#5
Shuro Yoshida, Hideho Henzan, Toshiyuki Ueno, Takuya Shimakawa, Yayoi Matsuo, Takuro Kuriyama, Noriyuki Saito, Ichiro Kawano, Akihiko Numata, Ken Takase, Tadafumi Iino, Tetsuya Eto
Background: The prognosis of allogeneic hematopoietic stem cell transplantation (HSCT) for non-remission hematological malignant diseases is usually unfavorable. The most uncontrollable factor is residual disease or relapse. To overcome this problem, intensified conditioning regimens- sequential and/or additional chemotherapy to the standard regimen- could be effective. However, increasing the intensity of conditioning might also lead to more complications. Materials and Methods: We retrospectively analyzed 81 patients with non-remission disease who received allogeneic HSCT in our institution between 2007 and 2011...
April 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/30233773/cholelithiasis-in-thalassemia-major-patients-a-report-from-the-south-east-of-iran
#6
Iraj Shahramian, Razieh Behzadmehr, Mahdi Afshari, Atefeh Allahdadi, Mojtaba Delaramnasab, Ali Bazi
Background: Cholelithiasis and its predisposing factors are less characterized in thalassemia syndromes. In the present study, we assessed the prevalence of gallstones and related-risk factors among thalassemia major (TM) patients in south-east of Iran. Materials and Methods: The patients were recruited form a single center in Zabol city, south-east of Iran. Demographic and clinical information were retrieved from medical histories. Abdominal ultrasonography was performed to scrutinize gallstones and organ dimensions of liver, spleen, gallbladder and kidney...
April 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/30233772/a-review-of-allogeneic-hematopoietic-stem-cell-transplantation-in-metastatic-breast-cancer
#7
REVIEW
Nuri Karadurmus, Ugur Sahin, Bilgin Bahadir Basgoz, Fikret Arpaci, Taner Demirer
Breast cancer (BC) has a high mortality rate and metastatic BC is almost incurable despite hormonal therapy and chemotherapy. The second and third lines of chemotherapies usually yield transient responses and the median survival is generally as low as 18-24 months. Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) have been extensively investigated in this setting. The presence of immune mediated anti-tumor effects referred to as graft-versus-tumor (GvT) effects after allogeneic HSCT among patients with solid tumors have been clearly defined...
April 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/30233771/investigation-of-ccr7-marker-expression-using-immunohistochemical-method-and-its-association-with-clinicopathologic-properties-in-patients-with-breast-cancer
#8
Laleh Vahedi, Maryam Ghasemi, Jamshid Yazdani, Samaneh Ranjbar, Banafshe Nouri, Ahad Alizadeh, Parvaneh Afshar
Background: Breast cancer is one of the most common cancers among women in the world, especially in Iran. There are large numbers of molecular and genomic factors causing breast cancer as well as many markers associated with tumor invasion. Chemokines are small proteins that primarily regulate leukocyte trafficking in the homeostatic conditions and specific immune responses. Chemokine receptor 7 (CCR7) belongs a class A subtype 7-span transmembrane G-protein coupled receptor. CCR7 plays a role in the migration of tumor cells such as immune cells into lymphoid organs through binding to its only two ligands CCL19/CCL21...
April 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/30233770/alopecia-areata-and-demyelination-as-paraneoplastic-manifestation-in-paediatric-hodgkin-s-lymphoma
#9
Shravan Kanaparthi, Shrikiran Aroor, Suneel C Mundkur, Sowmya Shashidhara, Kasi Viswanath Reddy
Hodgkin's Lymphoma is one of the commonly encountered lymphomas in childhood. Most of the children present with lymphadenopathy. A rare subset of children do present with constellation of atypical symptoms as paraneoplastic syndromes. We hereby present an 11-year-old boy with classical Hodgkin's Lymphoma associated with Alopecia areata and demyelination as paraneoplastic manifestations. Both these paraneoplastic manifestations improved after initiating chemotherapy (ABVD regimen). A high index of suspicion for underlying malignancy would help clinicians in clinching an early diagnosis and would avert the associated complications...
April 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/30233769/hemo-lymphopoietic-malignancies-surround-the-women-of-the-family-a-case-report-and-literature-review
#10
Behjat Kalantari-Khandani, Ali Akbar Haghdoost, Mohsen Momeni, Mina Danaei
The co-occurrence of different types of hemo-lymphopoietic malignancies within a family provides clues about the pattern of inheritance and common environmental risk factors. A family presented with developing hemo-lymphopoietic cancers in three female first-degree relatives: a mother and her daughters. Case 1 was diagnosed with Walden Strom's macroglobulinemia at age 57. Case 2 and 3 presented with chronic myelogenous leukemia at age 32 and diffuse large B-cell lymphoma at age 28, respectively. There were not any significant common environmental risk factors in this family, but all three cases suffered from skin dermatitis and one of them, who suffered from chronic myelogenous leukemia, was diagnosed with morphea...
April 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/30233768/a-double-blind-randomized-comparison-study-between-zytux%C3%A2-vs-mabthera%C3%A2-in-treatment-of-cll-with-fcr-regimen-non-inferiority-clinical-trial
#11
Gholamreza Toogeh, Mohammad Faranoush, Seyed Mohsen Razavi, Hassan Jalaeikhoo, Abolghasem Allahyari, Mohammad Reza Ravanbod, Fariba Zarrabi, Vahid Fallahazad, Ehsan Rezaei Darzi, Shadi Sadat Alizadeh Fard
BACKGROUND: Chronic lymphocytic leukemia (CLL) is characterized by accumulation of B cells in blood, lymphoid tissues and bone marrow. Addition of rituximab to CLL chemotherapy regimens has been associated with improved survival. The aim of this study was to establish efficacy and safety of Zytux™ in comparison to MabThera® in treatment of CLL. MATERIALS AND METHODS: Seventy CLL patients who met the criteria for entering the study were randomized into two groups (35 patients in each group)...
April 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/30233767/supplazithromycin-for-prevention-of-graft-versus-host-disease-a-randomized-placebo-controlled-trial
#12
Maryam Barkhordar, Mehdi Mohammadi, Molouk Hadjibabaie, Ardeshir Ghavamzadeh
Background: Allogeneic hematopoietic stem cell transplantation has been used widely to treat various types of malignant and non-malignant disorders. Graft-versus-host disease is one of the main complications of this procedure which is associated with considerable mortality and affects quality of life. Despite careful selection of HLA-matched donors and implementing immunosuppressive therapy, the incidence rate of graft-versus-host disease remains high. Macrolide antibiotics are well-known immunomodulatory agents and have been effective as prophylaxis for graft-versus-host disease in preclinical studies...
April 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951181/predictors-and-correlates-of-fatigue-in-sickle-cell-disease-patients
#13
Mehrnaz Ahmadi, Saeed Poormansouri, Samira Beiranvand, Ladan Sedighie
Background: Although fatigue is the most important symptom of Sickle Cell Disease, the extent of it is unknown, and causal mechanisms are not well understood. This article explores biopsychosocial characteristics that can potentially contribute to fatigue in SCD. Materials and Methods: This cross-sectional, correlational study included 97 SCD patients who aged over 16 years and had records in Thalassemia Ward and Clinic of Shafa Hospital affiliated to Ahvaz University of Medical Sciences, Ahvaz, Iran. Data were collected from a self- reported demographic questionnaire, measuring depression, anxiety stress scale (DASS-21) and fatigue severity scale (FSS)...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951180/clear-cell-sarcoma-a-case-report-and-review-of-literature
#14
Alireza Abdollahi, Fatemeh Khatami, Seyed Mohammad Tavangar
Clear cell sarcoma (CCS), a deep-rooted tumor with a predilection for lower extremities, has a proclivity to involve the tendons and aponeuroses. This sarcoma is seen predominantly around the foot and ankle region. Diagnosis is mainly finalized using histological and immunohistochemical assessment. The main treatment strategy is surgery followed by chemotherapy. An erratic challenge is posed by histological similarity and immunohistochemical overlap to the diagnosis and distinguishing of clear cell sarcoma from primary or metastatic malignant melanoma (MM) which is more common...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951179/assessing-prognostic-factors-in-hodgkin-s-lymphoma-multistate-illness-death-model
#15
Fatemeh Javanmardi, Amal Saki-Malehi, Ahmad Ahmadzadeh, Fakher Rahim
Background: Hodgkin's lymphoma (HL) is a unique cancer of lymphocytes that has unknown reason. As lymphocytes are found throughout the lymphatic system, HL can start almost anywhere in the body. It usually starts in a group of lymph nodes in one part of the body; it usually spreads in a predictable form, from one group of lymph nodes to the next. Eventually, it can spread to almost any tissue or organ in the body through the lymphatic system or the bloodstream. So it's important to evaluate the prognostic factors of mortality and recurrence...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951178/association-between-gt-n-repeats-in-heme-oxygenase-1-gene-promoter-and-3-year-survival-of-patients-with-acute-leukemia-a-controlled-cross-sectional-study
#16
Mohammad Kazemi, Farinaz Khosravian, Amir Abbas Sameti, Alireza Moafi, Mohammad Reza Merasi, Mansour Salehi, Majid Nejati, Mohaddeseh Behjati
Background: Acute leukemia is a common pediatric cancer. Novel strategies for treatment of acute leukemia have been developed, but treatment resistance is remained as the most problematic issue. It is hypothesized that the HO-1 gene up-regulation is responsible for tumor resistance to chemotherapy or radiotherapy-induced apoptosis. The levels of HO-1 expression are related to (GT)n microsatellite polymorphisms in the location of its promoter. This study designed to compare allelic frequencies of (GT)n microsatellite polymorphisms in HO-1 gene between acute leukemia patients and healthy controls...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951177/study-of-the-relationship-between-hpa-1-and-hpa-5-gene-polymorphisms-and-refractory-to-platelet-therapy-and-recombinant-factor-vii-in-glanzmann-thrombasthenia-patients-in-southeast-of-iran
#17
Majid Naderi, Manizheh Habibpour, Shaban Alizadeh, Zahra Kashani Khatib, Akbar Dorgalaleh, Mohammed Awal Issah, Fatemeh Naadali
Background: Glanzmann Thrombasthenia (GT) is a rare autosomal disease. HPA (Human Platelet Alloantigen) is a surface polymorphic alloantigen of platelets. This study was intended to investigate and compare the polymorphism of HPA-1 and HPA-5 genes in two groups of GT patients, with and without resistance to platelet and recombinant factor VII therapy. Materials and Methods: This case control study was performed on GT patients (n=16) with resistance to platelet therapy and recombinant factor VII and control group of GT patients (n=16) without resistance to platelet therapy and recombinant factor VII...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951176/comparative-evaluation-of-biochemical-and-hematological-parameters-of-pre-storage-leukoreduction-during-rbc-storage
#18
Behrooz Ghezelbash, Azita Azarkeivan, Ali Akbar Pourfathollah, Mohammadreza Deyhim, Esmerdis Hajati, Alireza Goodarzi
Background: Some of the red cell storage lesions (RCSLs) take place during red blood cell (RBC) storage and may reduce the function of these cells dramatically, which mostly caused by residual leucocytes in blood components. This study was planned to observe the biochemical and hematological changes in pre-storage leukoreduced RBC (LR-RBC) compared with unfiltered RBC during in vitro storage. Materials and Methods: Ten unit RBCs were collected, processed and stored according to Iranian standard operating procedure (SOP) of Iranian Blood Transfusion Organization (IBTO)...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951175/utility-of-a-single-tube-six-color-flow-cytometry-panel-for-the-diagnosis-of-myelodysplastic-syndrome-experience-of-a-tertiary-care-centre-in-india
#19
R Gupta, K Rahman, M K Singh, S Kumari, G Yadav, S Nityanand
Background: Diagnosis of myelodysplastic syndromes (MDS) is challenging in the presence of morphological mimickers. Flow cytometric immunophenotyping (FCI) has been added to the diagnostic armamentarium, but its use in clinical practice is variable. Materials and Methods: Bone marrow aspirate samples from 54 patients with a clinical and/or morphological suspicion of MDS were subjected to FCI using a single-tube, 6-colour panel comprising of monoclonal antibodies against CD13, CD11b, CD16, CD34, CD45 and CD56...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29951174/pattern-of-kebab-intake-as-a-potential-carcinogenic-risk-factor-in-adults-of-kermanshah-iran-2015
#20
Seyyed Mostafa Nachvak, Mahboobe Hosseinikia, Hadi Abdollahzad, Yahya Pasdar, Farhad Oubari, Roghaye Hosseinikia, Maryam Shabanpur
Background: Epidemiologic studies indicated that dietary pattern plays a determinant role in cancer incidence. They also indicated that 1/3 of cancers are associated to foods. Diet contains different carcinogenic agents: naturally occurring chemicals, synthetic components and compounds produced during cooking such as kebab. This traditional food is one of the most popular foods in the Middle East, particularly in Iran. Red meat, especially lamb or veal, is the most common meat used in preparation of kebab. Since kebab is considered as a food containing carcinogenic compounds, so the purpose of this study was to assess the consumption pattern of kebab in a sample of Iranian adults and its relationship with demographic characteristics...
January 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
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