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International Journal of Fertility & Sterility

Evangelos G Papanikolaou, Evi Timotheou, Petroula Tatsi, Hieronymus Janssens, Michael Grynberg, Apostolos Athanasiadis, Christina Zafeirati, Robert Najdecki, Stamatios Petousis
The efficacy of in vitro fertilization (IVF) for treating human infertility has only one final efficacy index and that is the achievement of a delivery. However, with the evolution of the freeze-all strategy, a new problem is arising for evaluating the performance of an embryological team. The aim of the study was to present a new representative index, combining fresh and frozen embryo transfer success rates. In this opinion article, apart from the effectiveness of managing fresh gametes and embryos, we wish to evaluate the efficacy of the processes of both freezing and thawing of the produced embryos...
January 2019: International Journal of Fertility & Sterility
Matías Angel Sirini, Juan Patricio Anchordoquy, Silvina Quintana, Cecilia Furnus, Alejandro Enrique Relling, Juan Mateo Anchordoquy
Energy balance is regulated by ghrelin which is a neuroendocrine modulator. Ghrelin is expressed in reproductive organs. However, the role of ghrelin during in vitro maturation (IVM) and bovine preimplantational development is limited. The purpose of this study was to measure the expression of ghrelin (GHRL) and its receptor growth hormone secretagogue receptor 1A (GHS-R1A) mRNA, and determine cumulus oocyte complex (COC) viability after IVM with 0, 20, 40 and 60 pM of ghrelin. Also, pronuclear formation was recorded after in vitro fertilization (IVF)...
January 2019: International Journal of Fertility & Sterility
Mahboobeh Shirazi, Parichehr Pooransari, Fatemeh Rahimi Sharbaf, S Hirin Niromanesh, Behrokh Sahebdel, Mamak Shariat, Zeinab Pahlavan, Mahmoud Shirazi, Maryam Ahmadian
Background: Antenatal anxiety or maternal stress is a prevalent chronic mental disorder in pregnant women. We have assessed the effect of maternal stress from positive aneuploidy screening results on the changes in uterine artery blood flow. Materials and Methods: We performed a prospective cohort (one sample) pilot study at a hospital in Tehran, Iran. A total of 60 pregnant women who were candidates for amniocentesis due to abnormal sequential screening test results entered the study...
January 2019: International Journal of Fertility & Sterility
Zahra Ezabadi, Fahimeh Mollaahmadi, Saeideh Sazvar, Samira Vesali, Reza Omani-Samani
Background: Potentially modifiable factors, such as the appropriate informing process given to infertile patients, can affect their infertility knowledge and information. This study aims to assess infertility information provided to Iranians who undergo assisted reproductive treatment. Materials and Methods: In this cross-sectional study, participants recruited were a convenience sample of all infertile patients who received assisted reproductive treatments from Royan Institute, Tehran, Iran...
January 2019: International Journal of Fertility & Sterility
Maryam Jahangirifar, Mahboubeh Taebi, Mohammad Hossein Nasr-Esfahani, G Holamreza Askari
Background: Infertility is one of the most common challenges that women in reproductive age would encounter today. The maternal nutritional status could be a determinant of oocyte quality and embryonic growth. This study was conducted to assess the relationship between dietary patterns and reproductive outcomes in infertile women. Materials and Methods: This prospective cohort study was conducted on 140 women with primary infertility who had referred to Isfahan Fertility and Infertility center, Isfahan, Iran...
January 2019: International Journal of Fertility & Sterility
Fatemeh Hassani, Shahrbanoo Oryan, Poopak Eftekhari-Yazdi, Masood Bazrgar, Ashraf Moini, Nahid Nasiri, Azadeh Ghaheri
Background: The objective of this study was to describe the association between luteinizing hormone (LH)/ follicle-stimulating hormone (FSH) ratio and demographic variables and maturation stage of oocytes in insulinresistant and insulin-sensitive patients with polycystic ovary syndrome (PCOS) in comparison with control group. Materials and Methods: In this case-control study, 60 patients with in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) indication were subdivided into 3 groups as follow: 20 subjects were assigned to control (fertile women with male infertility history) group, 20 subjects with PCOS were insulin resistant (IR) and 20 subjects with PCOS were insulin sensitive (IS)...
January 2019: International Journal of Fertility & Sterility
Mansour Moghimi, Somayeh Zabihi-Mahmoodabadi, Aliasghar Kheirkhah-Vakilabad, Zahra Kargar
Background: Human papillomavirus (HPV) is a DNA virus that causes sexually transmitted infections (STI). Recent reports suggest that HPV may affect sperm parameters and lead to male infertility. This study aims to evaluate the correlation between seminal high-risk HPV infection and impairment of sperm quality in infertile Iranian men. Materials and Methods: In this case-control study, we collected fresh semen samples from 70 fertile men and 70 confirmed infertile men who referred to Yazd Infertility Centre in 2015...
January 2019: International Journal of Fertility & Sterility
Hesamoddin Sajadi, Jalil Hosseini, Faramarz Farrahi, Farid Dadkhah, Mahdi Sepidarkish, Marjan Sabbaghian, Poopak Eftekhari-Yazdi, Mohammad Ali Sadighi Gilani
Background: Assessing the net-results of microsurgical varicocelectomy in infertile men with non-obstructive azoospermic (NOA) and clinical varicocele in five years at Royan Institute. Materials and Methods: This is a descriptive retrospective cohort study. A backward-looking review of patients treated for NOA and varicocele from march 2011 to march 2016 was performed. In addition, MDTESE results of 57 patients with NOA and clinical varicocele, with 537 NOA patients without varicocele were compared...
January 2019: International Journal of Fertility & Sterility
Azam Miraghazadeh, Mohammad Ali Sadighi Gilani, Fakhredin Reihani-Sabet, Azadeh Ghaheri, Parnaz Borjian Boroujeni, Mohammadreza Zamanian
Background: Microdeletions of the Yq chromosome are among the most frequent genetic etiological factor of male infertility which spans the azoospermia factor regions (AZFa, AZFb and AZFc). Microdeletions are mostly seen in the AZFc region and usually cover genes actively involved in spermatogenesis. Partial AZFc microdeletions may also occur with various spans, namely gr/gr, b2/b3 and b1/b3. It is known that the outcome of microtesticular sperm extraction (TESE), the surgical process for sperm retrieval from the testis in infertile azoospermic men, may be predicted based on the type of AZF microdeletion...
January 2019: International Journal of Fertility & Sterility
Zeinab Sadat Hosseiny, Parvaneh Nikpour, Abas Bakhtiary, Fatemah Sadat Mostafavi, Mohammad Matinfar, Mehrnaz Jahani, Roshanak Aboutorabi
Background: Osteopontin ( Opn ) is one of the co-factors involved in cell adhesion and invasion during the implantation process. Several reports have shown Opn expression changes in diabetic condition in several tissues. In addition, an increased incidence of spontaneous abortion is reported in diabetic women. We, therefore, designed a study to evaluate the effects of diabetes on Opn expression at implantation time after treatment with metformin and pioglitazone. Materials and Methods: In this interventional and experimental study, 28 rats were randomly divided into four groups, namely control, diabetic, pioglitazone-treated diabetic rats and metformin-treated diabetic rats...
January 2019: International Journal of Fertility & Sterility
Fereshteh Aslebahar, Hossein Neamatzadeh, Bahare Meibodi, Mojgan Karimi-Zarchi, Razieh Sadat Tabatabaei, Mahmood Noori-Shadkam, Mahta Mazaheri, Reihaneh Dehghani-Mohammadabadi
Background: Multiple studies have been carried out examining the association of tumor necrosis factor-α gene (TNF-α) promoter region polymorphisms with recurrent pregnancy loss (RPL) risk. However, the results remain controversial and incomplete. Hence, we performed a meta-analysis to evaluate the association of the TNF-α -308G>A and -238G>A polymorphisms with RPL risk. Materials and Methods: In this meta-analysis, a comprehensive search of PubMed, Web of Knowledge and EMBASE was performed to identify relevant studies published until December 1, 2017...
January 2019: International Journal of Fertility & Sterility
Reza Omani-Samani, Payam Amini, Behnaz Navid, Mahdi Sepidarkish, Saman Maroufizadeh, Amir Almasi-Hashiani
Infertile women are at a higher risk of sexual dysfunction compared to fertile women. Infertility is a major source of stress, anxiety, and depression, which strongly affects sexual health. The aim of this study is to estimate the prevalence of female sexual dysfunction (FSD) among infertile Iranian women. We searched the main international databases (Web of Science, PubMed, Medline, and Scopus) and national databases (Scientific Information Database, Magiran, and IranMedex) from their inception until April, 2017...
January 2019: International Journal of Fertility & Sterility
Parastoo Modarres, Marziyeh Tavalaee, Kamran Ghaedi, Mohammad Hossein Nasr-Esfahani
Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI). A variety of processes, organelles and structures are involved in acrosome biogenesis including, trans-golgi network (TGN), acroplaxome and cellular trafficking. This review aims to explain roles of related signals and molecules involved in this process and also describe how their absence in form of mutation, deletion and knockout model may lead to phenomenon referred to globozoospermia...
January 2019: International Journal of Fertility & Sterility
Asghar Beigi Harchegani, Ali Irandoost, Mahdiyeh Mirnamniha, Hamid Rahmani, Eisa Tahmasbpour, Alireza Shahriary
Calcium (Ca) is a significant element that acts as an intracellular second messenger. It is necessary for many physiological processes in spermatozoa including spermatogenesis, sperm motility, capacitation, acrosome reaction and fertilization. Although influences of Ca deficiency on sperm function and male infertility have been widely studied, mechanisms for these abnormalities are not well considered. Poor sperm motility, impairment of chemotaxis, capacitation, acrosome reaction and steroidogenesis are the major mechanisms by which Ca deficiency induces male infertility...
January 2019: International Journal of Fertility & Sterility
Ardeshir Bahmanimehr, Shahryar Zeighami, Bahia Namavar Jahromi, Zahra Anvar, Mohammad Ebrahim Parsanezhad, Maryam Davari, Somayeh Montazeri
Background: Y chromosome deletions (YCDs) in azoospermia factor (AZF) region are associated with abnormal spermatogenesis and may lead to azoospermia or severe oligozoospermia. Assisted reproductive technologies (ART) by intracytoplasmic sperm injection (ICSI) and testicular sperm extraction (TESE) are commonly required for infertility management of patients carrying YCDs. The aim of this study was to estimate the frequency of YCDs, to find the most frequent variant in infertile men candidate for ART and to compare YCD distribution with a control fertile group...
July 2018: International Journal of Fertility & Sterility
Meysam Jangkhah, Faramarz Farrahi, Mohammad Ali Sadighi Gilani, Seyed Jalil Hosseini, Farid Dadkhah, Reza Salmanyazdi, Mohammad Chehrazi
Background: The main purpose of this study is to evaluate the effects of varicocelectomy on serum testosterone levels and semen quality in infertile men who suffer from varicocele. MATERIALS AND METHODS: This prospective study enrolled 115 subjects with clinical varicocele grades II and III and 240 fertile men as the control group. Total volume of testosterone serum level (ng/dl) and semen quality were compared before and after microscopic varicocelectomy. We normalized testosterone serum levels for age, grade, and testis size basis...
July 2018: International Journal of Fertility & Sterility
Nafiye Yilmaz, Ebru Ersoy, Aytekin Tokmak, Ayla Sargin, A Seval Ozgu-Erdinc, Salim Erkaya, Halil Ibrahim Yakut
Background: Recent studies have shown that vitamin D has an essential role in the reproductive system. In this study, we aimed to investigate the effect of vitamin D levels in patients undergoing ovulation induction (OI), and subsequent intrauterine insemination (IUI) procedure. MATERIALS AND METHODS: One hundred and four infertile and one hundred and three fertile women were recruited in this cross-sectional study which was conducted in a tertiary level maternity hospital...
July 2018: International Journal of Fertility & Sterility
Saghar Saeedabadi, Amir Hossein Abazari-Kia, Hoda Rajabi, Kazem Parivar, Mohammad Salehi
Background: DNA methylation is one the epigenetic mechanisms, which is critically involved in gene expression. This phenomenon is mediated by DNA methyl-transferases and is affected by environmental stress, including in vitro maturation (IVM) of oocytes. Melatonin, as an antioxidant, may theoretically be involved in epigenetic regulation via reductions of reactive oxygen species. This study was performed to investigate DNA methylation and the possibility of goat oocyte development after treatment with different concentrations of melatonin...
July 2018: International Journal of Fertility & Sterility
Sahar Bagheri, Rasoul Roghanian, Naser Golbang, Pouran Golbang, Mohammad Hossein Nasr Esfahani
Background: Chlamydia trachomatis (CT) infection is the most common sexually transmitted disease in the world that can persist and also ascend in the genital tract. This intracellular and silent infection is related to some adverse pregnancy outcomes, such as miscarriage. The aims of this study were to explore the best CT screening tests using blood and vaginal samples and to investigate the correlation between CT infection and the incidence of miscarriage. MATERIALS AND METHODS: This case-control study was done in October 2013 through June 2014, using purposive sampling from 157 female participants with or without a history of miscarriage...
July 2018: International Journal of Fertility & Sterility
Zohreh Rahimi, Foroogh Chamaie-Nejad, Shohreh Saeidi, Ziba Rahimi, Ali Ebrahimi, Ebrahim Shakiba, Asad Vaisi-Raygani
Background: The aim of present study was to clarify the role of the peroxisome proliferator-activated receptor (PPAR) γ Pro12Ala and C161T polymorphisms in the pathogenesis of polycystic ovary syndrome (PCOS) and their influence on lipid and lipoprotein profiles of patients. MATERIALS AND METHODS: The present cross-sectional study consisted of 50 women with PCOS, who referred to the Kermanshah University of Medical Sciences Clinic between April and October 2015, and 233 unrelated age-matched healthy women from the same region (West Iran)...
July 2018: International Journal of Fertility & Sterility
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