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International Journal of Fertility & Sterility

Pouria HosseinNia, Mehdi Hajian, Mojtaba Tahmoorespur, Sayyed Morteza Hosseini, Somayyeh Ostadhosseini, Mohammad Reza Nasiri, Mohammad Hossein Nasr-Esfahani
BACKGROUND: Little is understood about the regulation of gene expression during early goat embryo development. This study investigated the expression profile of 19 genes, known to be critical for early embryo development in mouse and human, at five different stages of goat in vitro embryo development (oocyte, 8-16 cell, morula, day-7 blastocyst, and day 14 blastocyst). MATERIALS AND METHODS: In this experimental study, stage-specific profiling using real time-quantitative polymerase chain reaction (RT-qPCR) revealed robust and dynamic patterns of stage-specific gene activity that fall into four major clusters depending on their respective mRNA profiles...
October 2016: International Journal of Fertility & Sterility
Mohammad Mehdi Heidari, Mehri Khatami, Amirhossein Danafar, Tahere Dianat, Ghazaleh Farahmand, Ali Reza Talebi
BACKGROUND: Several recent studies have shown that mitochondrial DNA mutations lead to major disabilities and premature death in carriers. More than 150 mutations in human mitochondrial DNA (mtDNA) genes have been associated with a wide spectrum of disorders. Varicocele, one of the causes of infertility in men wherein abnormal inflexion and distension of veins of the pampiniform plexus is observed within spermatic cord, can increase reactive oxygen species (ROS) production in semen and cause oxidative stress and sperm dysfunction in patients...
October 2016: International Journal of Fertility & Sterility
Shabnam Zarei Moradi, Najmehsadat Masoudi, Anahita Mohseni Meybodi, Khadijeh Anisi Hemaseh, Ramin Mozafari Kermani, Abolhasan Shahzadeh Fazeli, Hamid Gourabi
BACKGROUND: To verify the hypothesis that the incidence of chromosomal abnormalities increases in babies conceived by different assisted reproduction procedures. The availability of the umbilical cord blood encouraged us to study this hypothesis via this method. MATERIALS AND METHODS: This is a descriptive study, umbilical cord blood samples of assisted reproductive technology (ART) children were analyzed with standard cytogenetic techniques (G banding). Karyotyping was possible in 109 cases...
October 2016: International Journal of Fertility & Sterility
Seyedeh Zahra Masoumi, Maryam Garousian, Somayeh Khani, Seyedeh Reyhaneh Oliaei, Arezoo Shayan
BACKGROUND: Fertility plays an important role in sexual and psychological function in families. Infertility can result in major emotional, social, and mental disorders, including a reduction in satisfaction with marital life and quality of life. The present study aimed to compare the quality of life and marital satisfaction and sexual satisfaction between fertile and infertile couples. MATERIALS AND METHODS: This analytical cross-sectional study was conducted on 250 couples at the Fatemiyeh Educational Research Center affiliated to Hamadan University of Medical Sciences, Hamadan, Iran, from May to August in 2014...
October 2016: International Journal of Fertility & Sterility
Mehrandokht Abedini, Azadeh Ghaheri, Reza Omani Samani
BACKGROUND: Due to the worldwide increase in infertility, it is both necessary and important to have assisted reproductive technology (ART) registries. In Iran, donation and surrogacy programs are approved by decrees from religious scholars. ART has been used since 1984 in Iran and the first Iranian infant conceived by gamete intra-fallopian transfer (GIFT) was born in 1989. This report, however, is the first national report on Iranian ART centers. MATERIALS AND METHODS: This cross-sectional study, conducted under the supervision of the Iranian Ministry of Health, presented a summary of the numbers and percentages of centers that provided infertility services in Iran, as well as the status of ART in Iran during 2011...
October 2016: International Journal of Fertility & Sterility
Mahdi Sepidarkish, Amir Almasi-Hashiani, Fatemeh Shokri, Samira Vesali, Elaheh Karimi, Reza Omani Samani
BACKGROUND: Few studies have been conducted on the infertility problems in Iran. This study aimed to investigate the prevalence of infertility problems and related factors in Iranian infertile patients. MATERIALS AND METHODS: In this cross sectional study, 405 infertile patients referred to Royan Institute, Tehran, Iran, between 2014 and 2015, were selected by simple random sampling. Participants completed the Fertility Problem Inventory (FPI) including 46 questions in five domains (social concern, sexual concern, relationship concern, rejection of parenthood, and need for parenthood)...
October 2016: International Journal of Fertility & Sterility
Hatem Abu Hashim
Orally active aromatase inhibitors (AIs) have gained attention for treatment of infertile women with endometriosis in whom aromatase p450 is aberrantly expressed. This review aimed to critically appraise and summarize the available evidence concerning the use of AIs for management of endometriosis-associated infertility. PubMed was searched to May 2015 with the following key words: endometriosis, infertility and aromatase. Priority was given for randomized controlled trials (RCTs) followed by other study designs...
October 2016: International Journal of Fertility & Sterility
Antonio Simone Laganà, Salvatore Giovanni Vitale, Paola Iaconianni, Simona Gatti, Francesco Padula
Male fertility significantly decreased in the last 50 years, as showed in several studies reporting a reduction of sperm counts per ml in the seminal fluid. Several "acute" pharmacological treatments, as antibiotics, could cause subclinical and temporary reduction of male fertility; conversely, long-term medical treatment may severely affect male fertility, although this effect could be considered transient in most of the cases. Thus, nowadays, several long-term pharmacological treatments may represent a clinical challenge...
October 2016: International Journal of Fertility & Sterility
Adrija Kumar Datta
No abstract text is available yet for this article.
July 2016: International Journal of Fertility & Sterility
Naeimeh Sadat Abtahi, Bita Ebrahimi, Rouhollah Fathi, Sepideh Khodaverdi, Abolfazl Mehdizadeh Kashi, Mojtaba Rezazadeh Valojerdi
From December 2000 until 2010, the researchers at Royan Institute conducted a wide range of investigations on ovarian tissue cryopreservation with the intent to provide fertility pres- ervation to cancer patients that were considered to be candidates for these services. In 2010, Royan Institute established the Royan Human Ovarian Tissue Bank as a subgroup of the Embryology Department. Since its inception, approximately 180 patients between the ages of 747 years have undergone consultations. Ovarian samples were cryopreserved from 47 patients (age: 7-35 years) diagnosed with cervical adenocarcinoma (n=9); breast carcinoma (n=7), Ewing's sarcoma (n=7), opposite side ovarian tumor (n=7), endometrial adenocarci- noma (n=4), malignant colon tumors (n=3), as well as Hodgkin's lymphoma, major thalas- semia and acute lymphoblastic leukemia (n=1-2 patients for each disease)...
July 2016: International Journal of Fertility & Sterility
Mohammad Hossein Nasr Esfahani, Mohammad Reza Deemeh, Marziyeh Tavalaee, Mohammad Hadi Sekhavati, Hamid Gourabi
BACKGROUND: Selection of sperm for intra-cytoplasmic sperm injection (ICSI) is usually considered as the ultimate technique to alleviate male-factor infertility. In routine ICSI, selection is based on morphology and viability which does not necessarily preclude the chance injection of DNA-damaged or apoptotic sperm into the oocyte. Sperm with high negative surface electrical charge, named "Zeta potential", are mature and more likely to have intact chromatin. In addition, X-bearing spermatozoa carry more negative charge...
July 2016: International Journal of Fertility & Sterility
Hamid Reza Momeni, Najmeh Eskandari
BACKGROUND: The aim of this study was to investigate the effects of curcumin on epididy- mal sperm parameters in adult male Navel Medical Research Institute (NMRI) mice ex- posed to sodium arsenite. MATERIALS AND METHODS: In this experimental study, we divided the animals into four groups: control, sodium arsenite (5 mg/kg), curcumin (100 mg/kg) and curcumin+sodium arsenite. Exposures were performed by intraperitoneal injections for a 5-week period. After the exposure period, we recorded the animals' body and left testes weights...
July 2016: International Journal of Fertility & Sterility
Batool Rahmati, Mohammad Hassan Ghosian Moghaddam, Mohsen Khalili, Ehsan Enayati, Maryam Maleki, Saeedeh Rezaeei
BACKGROUND: Opioid consumption has been widely increasing across the globe; how- ever, it can cause adverse effects on the body. Morphine, an opioid, can reduce sex hor- mones and fertility. Withania somnifera (WS) is a traditional herb used to improve sexual activities. This study strives to investigate the effect of WS on sex hormones and gonado- tropins in addicted male rats. MATERIALS AND METHODS: In this experimental study, forty-eight male National Maritime Research Institute (NMRI) rats were randomly divided into four groups: i...
July 2016: International Journal of Fertility & Sterility
Gholamreza Najafi, Elham Atashfaraz, Farah Farokhi
BACKGROUND: Methotrexate (MTX), as an anti-folate agent, is widely used in the treatment of rheumatic disorders and malignant tumors, however it damages reproductive sys- tem in mice. The aim of this research was to study the effects of ethyl pyruvate (EP) on embryo development and oxidative stress changes in the testis of mice treated with MTX. MATERIALS AND METHODS: In this experimental study, thirty-two adult male Naval Medical Research Institute mice, with average weight of 26 ± 2 g, were divided into four groups...
July 2016: International Journal of Fertility & Sterility
Analía Risso, Francisco Javier Pellegrino, Alejandro Enrique Relling, Yanina Corrada
BACKGROUND: Manipulating the dietary fatty acid (FA) content can alter FA profiles of reproductive tissues. Numerous researchers have evaluated the effect of fish oil (FO) supplementation on reproductive characteristics in domestic animals, but reliable information concerning dietary FO effects on semen quality and testosterone concentrations in dogs has not been reported. Therefore, this study evaluated the effects of dietary FO on semen quality and serum testosterone concentrations in dogs...
July 2016: International Journal of Fertility & Sterility
Mostafa Jamalan, Mohammad Ali Ghaffari, Pooneh Hoseinzadeh, Mahmoud Hashemitabar, Majid Zeinali
BACKGROUND: Metals can cause male infertility through affection of spermatogenesis and sperm quality. Strong evidences confirm that male infertility in metal-exposed humans is mediated via various mechanisms such as production of reactive oxygen species (ROS). Flavonoids have antioxidant and metal chelating properties which make them suitable candidates for neutralizing adverse effects of metals on semen quality. In the current study, we have evaluated the effects of five types of flavonoids (rutin, naringin, kaempferol, quercetin, and catechin) on recovery of sperm motility and prevention of membrane oxidative damage from aluminum chloride (AlCl3), cadmium chloride (CdCl2), and lead chloride (PbCl4)...
July 2016: International Journal of Fertility & Sterility
Gabriela Ruth Mendeluk, Mónica Rosales
BACKGROUND: The aim of this study was to evaluate the non-genomic action of thyroxin on sperm kinetic and its probable use to improve sperm recovery after applying an en- richment method like "swim-up" in comparison with the available one, pentoxifylline. MATERIALS AND METHODS: This is an experimental study. A total of 50 patients were re- cruited, followed by infertility consultation. Conventional sperm assays were performed according to World Health Organization criteria-2010 (WHO-2010)...
July 2016: International Journal of Fertility & Sterility
Parastoo Modarres, Somayeh Tanhaei, Marziyeh Tavalaee, Kamran Ghaedi, Mohammad Reza Deemeh, Mohammad Hossein Nasr-Esfahani
BACKGROUND: Globozoospermia is a rare syndrome with an incidence of less than 0.1% among infertile men. Researchers have recently identified a large deletion, about 200 kbp, encompassing the whole length of DPY19L2 or mutations in SPATA16 and PICK1 genes associated with globozoospermia. The aim of this study was to analyze the DPY19L2 gene deletion using polymerase chain reaction technique for the exons 1, 48, 11 and 22 as well as break point (BP) "a" in globozoospermic men. MATERIALS AND METHODS: In this experimental study, genome samples were collected from 27 men with globozoospermia (cases) and 36 fertile individuals (controls), and genomic analysis was carried out on each sample...
July 2016: International Journal of Fertility & Sterility
Maliheh Salimi, Zahra Alishah, Homayoun Khazali, Fariba Mahmoudi
BACKGROUND: Orexin is a hypothalamic orexigenic neuropeptide, which third cerebral injection of it mainly exerts inhibitory effects on reproductive functions. It increases significantly the Aromatase (Cyp19) gene expression in the hypothalamus of male rats. Aromatase is an enzyme which converts androgens to estradiol in the hypothalamus of rats. Prenatal or neonatal exposure of females to testosterone masculinizes the pattern of Cyp19 mRNA levels in adulthood. In the present study the effects of central injections of orexin-A on hypothalamic Cyp19 gene expression of adult female rats were investigated, while they had been androgenized on third day of postnatal life...
July 2016: International Journal of Fertility & Sterility
Reza Omani Samani, Saman Maroufizadeh, Zahra Ezabadi, Leila Alizadeh, Samira Vesali
BACKGROUND: In 1993, Muller developed the Prenatal Attachment Inventory (PAI) which has been used widely in many studies and translated into several languages. The current study aimed to translate the PAI into Persian, assess the underlying structure of the PAI, and the appropriateness of the one-factor solution proposed by Muller. MATERIALS AND METHODS: In this cross-sectional study, we recruited a total of 322 primi- gravidae in their 27(th) to 34(th) gestational weeks that referred to private and governmental prenatal clinics in Tehran, Iran...
July 2016: International Journal of Fertility & Sterility
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