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Drugs in Context

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https://www.readbyqxmd.com/read/27803726/lanthanum-carbonate-oral-powder-satisfaction-preference-and-adherence-in-french-and-spanish-patients-with-end-stage-renal-disease
#1
Michael Keith, Patricia de Sequera, François Clair, Riccardo Pedersini
BACKGROUND: Phosphate binders, such as lanthanum carbonate, control elevated serum-phosphate levels in patients with end-stage renal disease (ESRD). Lanthanum carbonate is available in oral powder and tablet form. The aim of this survey was to investigate satisfaction with, preference for, and adherence to lanthanum carbonate oral powder in patients with ESRD. SCOPE: Patients from France and Spain who had been taking lanthanum carbonate powder for at least 4 weeks, and who had experience of other phosphate binders of any formulation, were asked to complete an online or telephone survey...
2016: Drugs in Context
https://www.readbyqxmd.com/read/27708677/pharmacoeconomic-comparison-of-aripiprazole-once-monthly-and-paliperidone-palmitate-from-a-head-to-head-clinical-trial-in-schizophrenia-a-us-analysis
#2
Christophe Sapin, Ann Hartry, Siddhesh A Kamat, Maud Beillat, Ross A Baker, Anna Eramo
Schizophrenia presents a substantial clinical and economic burden to the health-care system. In QUAlity of LIfe with AbiliFY Maintena (QUALIFY), a randomized head-to-head study of aripiprazole once-monthly 400 mg (AOM 400) compared with paliperidone palmitate (PP; 78-234 mg/mo), AOM 400 demonstrated greater improvement in health-related quality of life and functioning in patients with stable schizophrenia. The present analysis used health economics assessment data collected during the QUALIFY study to determine the direct medical and pharmacy costs and the cost-effectiveness associated with each treatment over 6 months...
2016: Drugs in Context
https://www.readbyqxmd.com/read/27648101/closing-the-knowledge-gap-on-cardiovascular-disease-in-type-2-diabetes-the-empa-reg-outcome-trial-and-beyond
#3
REVIEW
Elif A Oral
Type 2 diabetes mellitus (T2DM) is associated with marked cardiovascular (CV) morbidity and mortality, including heart failure (HF). Until recently, an oral glucose-lowering agent that improved hyperglycemia as well as provided CV benefits in patients with T2DM and cardiovascular disease (CVD) was lacking. The newest class of glucose-lowering agents, sodium glucose cotransporter 2 (SGLT2) inhibitors, includes canagliflozin, dapagliflozin, and empagliflozin. Prior to the release of the LEADER trial results, the recent EMPA-REG OUTCOME study was the only dedicated CV trial to demonstrate a reduction in major adverse cardiac events, CV mortality, and all-cause mortality and a reduction in hospitalization for HF with empagliflozin, given on top of standard-of-care therapy in patients with T2DM and CVD...
2016: Drugs in Context
https://www.readbyqxmd.com/read/27540409/evaluating-cost-benefits-of-combination-therapies-for-advanced-melanoma
#4
Ivar S Jensen, Emily Zacherle, Christopher M Blanchette, Jie Zhang, Wes Yin
BACKGROUND: Although a number of monoimmunotherapies and targeted therapies are available to treat BRAF+ advanced melanoma, response rates remain relatively low in the range of 22-53% with progression-free survival (PFS) in the range of 4.8-8.8 months. Recently, combination targeted therapies have improved response rates to about 66-69%, PFS to 11.0-12.6 months and overall survival (OS) to 25.1-25.6 months. While combination immunotherapies have improved response rates of 67 compared with 19-29% with monotherapies and improved PFS of 11...
2016: Drugs in Context
https://www.readbyqxmd.com/read/27540408/influenza-vaccination-key-facts-for-general-practitioners-in-europe-a-synthesis-by-european-experts-based-on-national-guidelines-and-best-practices-in-the-united-kingdom-and-the-netherlands
#5
George Kassianos, Patricia Blank, Oana Falup-Pecurariu, Ernest Kuchar, Jan Kyncl, Raul Ortiz De Lejarazu, Aneta Nitsch-Osuch, Gerrit A van Essen
Currently there is no influenza vaccination guidance for European general practitioners. Furthermore, although the European Council recommends a target seasonal influenza vaccination rate of 75% in the elderly (65 years and above) and in anyone aged >6 months with a chronic medical condition, there remain wide discrepancies throughout Europe. A harmonised guideline regarding not only vaccination strategy but also for the consistent diagnosis of influenza across Europe is essential to support a common approach for the implementation of seasonal influenza vaccination across Europe...
2016: Drugs in Context
https://www.readbyqxmd.com/read/27403194/clinical-and-cost-outcomes-from-different-hyaluronic-acid-treatments-in-patients-with-knee-osteoarthritis-evidence-from-a-us-health-plan-claims-database
#6
Vinod Dasa, Mitch DeKoven, Kainan Sun, Allan Scott, Sooyeol Lim
BACKGROUND: Intra-articular injection of hyaluronic acid (HA) for knee osteoarthritis (OA) effectively reduces pain and delays total knee replacement (TKR) surgery; however, little is known about relative differences in clinical and cost outcomes among different HA products. OBJECTIVE: To compare disease-specific costs and risk of TKR among patients receiving different HA treatments in a commercially insured cohort of patients with knee OA in the USA. METHOD: Retrospective analyses using IMS Health's PharMetrics Plus Health Plan Claims Database were conducted by identifying knee OA patients with claims indicating initiation of HA treatment at an 'index date' during the selection period (2007-2010)...
2016: Drugs in Context
https://www.readbyqxmd.com/read/27403193/anticoagulation-for-the-prevention-of-stroke-in-non-valvular-af-in-general-practice-room-for-improvement
#7
Adam Ioannou, Sofia Metaxa, George Kassianos, Constantinos G Missouris
OBJECTIVE: Our aim was to assess whether the recommendations and guidelines for thromboprophylaxis in patients with atrial fibrillation (AF) have been adopted in general practice (GP). METHODS: We conducted a retrospective study using the GP computer database (Hatfield, UK) on all 9400 patients to assess the quality of anticoagulation in patients with a recorded diagnosis of AF. RESULTS: Of the 180 patients with a diagnosis of AF, 107 (59...
2016: Drugs in Context
https://www.readbyqxmd.com/read/27403192/efficacy-of-telbivudine-with-conditional-tenofovir-intensification-in-patients-with-chronic-hepatitis-b-results-from-the-2-year-roadmap-strategy
#8
Teerha Piratvisuth, Piyawat Komolmit, Henry Ly Chan, Tawesak Tanwandee, Wattana Sukeepaisarnjaroen, Mário G Pessoa, Eduardo Fassio, Suzane K Ono, Fernando Bessone, Jorge Daruich, Stefan Zeuzem, Michael Manns, Alkaz Uddin, Yuhong Dong, Aldo Trylesinski
BACKGROUND: A 2-year roadmap study was conducted to evaluate the efficacy and safety of tenofovir intensification at Week 24 in patients with chronic hepatitis B (CHB) receiving telbivudine. SCOPE: A prospective multicenter study was conducted in treatment-naive patients with hepatitis B e antigen (HBeAg)-positive CHB. All patients received telbivudine (600 mg/day) until Week 24. Thereafter, patients with detectable hepatitis B virus (HBV) DNA (≥300 copies/mL) were administered tenofovir (300 mg/day) plus telbivudine, and patients with undetectable HBV DNA continued telbivudine monotherapy until Week 104...
2016: Drugs in Context
https://www.readbyqxmd.com/read/27114741/human-plasma-derived-fviii-vwd-concentrate-biostate-a-review-of-experimental-and-clinical-pharmacokinetic-efficacy-and-safety-data
#9
REVIEW
Paul Harper, Emmanuel J Favaloro, Julie Curtin, Chris Barnes, Scott Dunkley
Human plasma-derived factor VIII/von Willebrand factor complex concentrates are used to control bleeding in patients with von Willebrand disease (VWD) or haemophilia A (HA). The properties of these haemostatic factor concentrates vary widely, which can have significant clinical implications. This review provides an extensive overview of the molecular properties, in addition to pharmacokinetic, efficacy and safety data, and case studies of clinical experience of one such concentrate, Biostate. These data are discussed in the context of various therapeutic applications and compared with other factor concentrate products...
2016: Drugs in Context
https://www.readbyqxmd.com/read/27114740/effectiveness-tolerability-and-practical-application-of-the-newer-generation-anti-obesity-medications
#10
REVIEW
Jeffrey S MacDaniels, Thomas L Schwartz
OBJECTIVE: Comparison of the efficacy and tolerability of five newer anti-obesity medications to guide clinical decision making, examining bupropion-naltrexone combination, liraglutide, lorcaserin, orlistat, and phentermine-topiramate combination. METHODS: A brief literature review and internet search for high-powered, randomized and placebo-controlled drug trials was conducted. Drug trial information was established for five currently approved anti-obesity medications...
2016: Drugs in Context
https://www.readbyqxmd.com/read/27114739/inpatient-resource-use-and-costs-associated-with-switching-from-oral-antipsychotics-to-aripiprazole-once-monthly-for-the-treatment-of-schizophrenia
#11
Michele Wilson, Benjamin Gutierrez, Steve J Offord, Christopher M Blanchette, Anna Eramo, Stephanie Earnshaw, Siddhesh A Kamat
BACKGROUND: Schizophrenia is associated with high direct healthcare costs due to progression of disease and frequent occurrence of relapses. Aripiprazole once-monthly (AOM) has been shown to reduce total psychiatric hospitalizations among patients who switched from oral standard of care (SOC) therapy to AOM in a multicenter, open-label, mirror-image study of patients with schizophrenia. Because of the increasing need to improve patient outcomes while containing costs, it is important to understand the impact of AOM treatment initiation on medical costs associated with psychiatric hospitalizations and antipsychotic pharmacy costs...
2016: Drugs in Context
https://www.readbyqxmd.com/read/26633984/combination-therapy-in-type-2-diabetes-mellitus-adding-empagliflozin-to-basal-insulin
#12
Andrew Ahmann
Type 2 diabetes mellitus (T2DM) management is complex, with few patients successfully achieving recommended glycemic targets with monotherapy, most progressing to combination therapy, and many eventually requiring insulin. Sodium glucose cotransporter 2 (SGLT2) inhibitors are an emerging class of antidiabetes agents with an insulin-independent mechanism of action, making them suitable for use in combination with any other class of antidiabetes agents, including insulin. This review evaluates a 78-week, randomized, double-blind, placebo-controlled trial investigating the impact of empagliflozin, an SGLT2 inhibitor, as add-on to basal insulin in patients with inadequate glycemic control on basal insulin, with or without metformin and/or a sulfonylurea...
2015: Drugs in Context
https://www.readbyqxmd.com/read/26576188/antidepressant-efficacy-and-side-effect-burden-a-quick-guide-for-clinicians
#13
REVIEW
Daniel Santarsieri, Thomas L Schwartz
Prescribing of antidepressant treatment (ADT) for major depressive disorder (MDD) has increased in quantity and popularity over the last two decades. This is likely due to the approval of safer medications, better education of clinicians and their patients, direct-to-consumer marketing practices, and less stigma associated with those taking ADT. This trend has also been met with some controversy, however, as the ongoing safety and effectiveness of these treatments have at times been called into question. This paper discusses the differing levels of evidence that support the use of ADT based on (A) Food and Drug Administration approvals, (B) data from randomized controlled trials or meta-analyses and, where these are not available, the authors discuss and apply, (C) theoretical pharmacodynamic principles to justify antidepressant choice in the treatment of MDD patients...
2015: Drugs in Context
https://www.readbyqxmd.com/read/26576187/metastatic-squamous-cell-non-small-cell-lung-cancer-nsclc-disrupting-the-drug-treatment-paradigm-with-immunotherapies
#14
REVIEW
Sarah L Scarpace
Lung cancer is the third most commonly diagnosed cancer and the leading cause of cancer-related death in the United States. Unlike non-squamous NSCLC, squamous NSCLC rarely harbor epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) mutations for which there are directed therapies, and until the recent approval of immunotherapies for squamous NSCLC, a limited number of traditional cytotoxic chemotherapy drugs have been FDA-approved for use in the treatment of advanced and metastatic squamous NSCLC...
2015: Drugs in Context
https://www.readbyqxmd.com/read/26322116/effect-of-variations-in-treatment-regimen-and-liver-cirrhosis-on-exposure-to-benzodiazepines-during-treatment-of-alcohol-withdrawal-syndrome
#15
Pavel Gershkovich, Kishor M Wasan, Charles Ribeyre, Fady Ibrahim, John H McNeill
PURPOSE: Benzodiazepines (BDZs) are the drugs of choice to prevent the symptoms of alcohol withdrawal syndrome (AWS). Various treatment protocols are published and have been shown to be effective in both office-managed and facility-managed treatment of AWS. The aim of this scientific commentary is to demonstrate the differences in the expected exposure to BDZs during AWS treatment using different treatment regimens available in the literature, in patients with or without alcoholic liver cirrhosis...
2015: Drugs in Context
https://www.readbyqxmd.com/read/26322115/alpha-2-receptor-agonists-for-the-treatment-of-posttraumatic-stress-disorder
#16
REVIEW
Molly R Belkin, Thomas L Schwartz
Clonidine and guanfacine are alpha-2 receptor agonists that decrease sympathetic outflow from the central nervous system. Posttraumatic stress disorder (PTSD) is an anxiety disorder that is theorized to be related to a hyperactive sympathetic nervous system. Currently, the only US Food and Drug Administration (FDA)-approved medications for PTSD are the selective serotonin reuptake inhibitors (SSRIs) sertraline and paroxetine. Sometimes use of the SSRIs may not lead to full remission and symptoms of hyperarousal often persist...
2015: Drugs in Context
https://www.readbyqxmd.com/read/26322114/an-assessment-of-chemotherapy-induced-nausea-and-vomiting-direct-costs-in-three-eu-countries
#17
Marco Turini, Vittoria Piovesana, Pierfrancesco Ruffo, Claudio Ripellino, Nazarena Cataldo
BACKGROUND: chemotherapy-induced nausea and vomiting (CINV) has been commonly reported as one of the most distressing adverse effects among treated patients with cancer. Inadequately treated, CINV can lead to increased resource utilization and severely impair patients' daily functioning and quality of life. Direct costs include acquisition cost of antiemetic drugs and rescue medication, administration devices, add-on treatments, such as hydration, and additional patient care, that is, nursing and physician time, unscheduled office visits, emergency room admissions, and, in some cases, extended hospitalization or readmission...
2015: Drugs in Context
https://www.readbyqxmd.com/read/26213556/a-clinical-review-of-glp-1-receptor-agonists-efficacy-and-safety-in-diabetes-and-beyond
#18
REVIEW
Lalita Prasad-Reddy, Diana Isaacs
The prevalence of type 2 diabetes is increasing at an astounding rate. Many of the agents used to treat type 2 diabetes have undesirable adverse effects of hypoglycemia and weight gain. Glucagon-like peptide-1 (GLP-1) receptor agonists represent a unique approach to the treatment of diabetes, with benefits extending outside glucose control, including positive effects on weight, blood pressure, cholesterol levels, and beta-cell function. They mimic the effects of the incretin hormone GLP-1, which is released from the intestine in response to food intake...
2015: Drugs in Context
https://www.readbyqxmd.com/read/26213555/a-review-of-current-treatment-strategies-for-gestational-diabetes-mellitus
#19
REVIEW
Kristi W Kelley, Dana G Carroll, Allison Meyer
Approximately 90% of diabetes cases in pregnant women are considered gestational diabetes mellitus (GDM). It is well known that uncontrolled glucose results in poor pregnancy outcomes in both the mother and fetus. Worldwide there are many guidelines with recommendations for appropriate management strategies for GDM once lifestyle modifications have been instituted and failed to achieve control. The efficacy and particularly the safety of other treatment modalities for GDM has been the source of much debate in recent years...
2015: Drugs in Context
https://www.readbyqxmd.com/read/26082796/diagnosis-and-management-of-lentigo-maligna-a-review
#20
REVIEW
Julia M Kasprzak, Yaohui G Xu
Lentigo maligna is a melanocytic neoplasm occurring on sun-exposed skin, usually on the head and neck, of middle-aged and elderly patients. It is thought to represent the in situ phase of lentigo maligna melanoma. The ill-defined nature and potentially large size of lesions can pose significant diagnostic and treatment challenges. The goal of therapy is to cure the lesions in order to prevent development of invasive disease, and surgical excision is the treatment of choice to achieve clear histological margins...
2015: Drugs in Context
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