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Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology

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https://www.readbyqxmd.com/read/29786546/flt3-itd-compared-with-dnmt3a-r882-mutation-is-a-more-powerful-independent-inferior-prognostic-factor-in-adult-aml-patients-after-allogeneic-hematopoietic-stem-cell-transplantation-a-retrospective-cohort-study
#1
Majid Teremmahi Ardestani, Ahmad Kazemi, Bahram Chahardouli, Saeed Mohammadi, Mohsen Nikbakht, Shahrbano Rostami, Mahdi Jalili, Mohammad Vaezi, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
OBJECTIVE: To identify DNMT3A exon 23 mutations and their prognostic impact in the presence of FLT3-ITD and NPM1 mutations in acute myeloid leukemia (AML) patients treated with Allo-HSCT. MATERIALS AND METHODS: This study analyzed128 adult AML patients referred to the Hematology-Oncology & Stem Cell Research Center of Shariati hospital. FLT3-ITD and NPM1 mutations were detected using fragment analysis. For DNMT3A exon 23 mutation analysis, we used Sanger sequencing...
May 22, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29781803/tendency-of-k562-chronic-myeloid-leukemia-cells-towards-cell-reprogramming
#2
Açelya Yılmazer Aktuna
Cancer cell reprogramming is a potential tool to study cancer progression, disease pathology and drug sensitivity. Prior to performing cancer reprogramming studies, it is important to evaluate the stemness predisposition of cells that will be reprogrammed. Here, we performed a proof-of-concept study with chronic myeloid leukemia K562 cells in order to evaluate their tendency for cancer cell reprogramming. Expression of reprogramming factors, pluripotency markers and tumor-suppressor genes were analyzed at gene and protein level via real-time RT-PCR and flow cytometry...
May 21, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29726398/aggressive-clinicopathological-course-of-myeloma-with-t-3-16-q21-q22-cytogenetic-abnormality
#3
Süreyya Bozkur, Müfide Okay, C İbrahim Haznedaroğlu
Key Words: Multiple myeloma, rare translocations, cytogenetic abnormality.
May 4, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29716882/vacuolization-in-myeloid-and-erythroid-precursors-in-a-child-with-menkes-disease
#4
Seçil Sayın, Şule Ünal, Mualla Cetin, Fatma Gumruk
A five year-old boy, who was under follow-up with a clinical and biochemical diagnosis of Menkes Disease (MD) since ten months of age, was admitted with diarrhea. On examination he had a characteristic cherubic face hypopigmented, sparse hair, hepatosplenomegaly, hypotonia with brisk deep tendon reflexes. Hemogram revealed: Hb:5.5g/dL, Hct:16.2%, RBC:1.69x1012/L, MCV:95.8fL, MCH:32.3pg, RDW:19.2%, WBC:2.2x109/L and platelet count;157x109/L. Serum vitamin B12 level was 575pg/mL. Serum copper level was 81μg/dL and serum zinc level was 152μg/dL...
April 30, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29666040/results-of-the-haematology-laboratory-survey-what-has-changed-in-8-years
#5
İlknur Kozanoğlu, Türkan Patıroğlu, Klara Dalva, Gülderen Yanıkkaya Demirel, Teoman Soysal, Muzaffer Demir
No abstract text is available yet for this article.
April 18, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29666036/report-on-three-patients-with-blastic-plasmacytoid-dendritic-cell-neoplasm
#6
Hale Bülbül, Nazan Özsan, Mine Hekimgil, Güray Saydam, Mahmut Töbü
No abstract text is available yet for this article.
April 18, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29666035/anemia-and-its-effect-on-cardiovascular-findings-in-obese-adolescents
#7
Öner Yıldırım, Tülay Demircan, Özlem Tüfekçi, Özgür Kızılca, Pınar Kuyum, Mustafa Kır, Ayhan Abacı, Nurettin Ünal, Nur Arslan, Ece Böber, Şebnem Yılmaz, Hale Ören
OBJECTIVE: We assessed the effect of anemia on cardiovascular findings in obese adolescents. MATERIALS AND METHODS: We studied 29 anemic, 33 nonanemic obese adolescents, and 33 nonobese healthy adolescents. These three groups were investigated for clinical and laboratory features of anemia and obesity. Echocardiography was used to examine cardiac functions. RESULTS: The anemia was mild (mean hemoglobin 11.67±0.79g/dL), ferritin level was significantly low, and CRP and fibrinogen levels were significantly high in anemic obese patients...
April 18, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29589834/hierarchical-involvement-of-myeloid-derived-suppressor-cells-and-monocytes-expressing-latency-associated-peptide-in-plasma-cell-dyscrasias
#8
Tamar Tadmor, Ilana Levy, Zahava Vadasz
Plasma cell dyscrasias (PCD) are disorders of the plasma cells having in common the production of a monoclonal M-protein. They include a spectrum of conditions which may represent a natural progression of the same disease from monoclonal gammopathy of unknown significance (MGUS), to asymptomatic and symptomatic multiple myeloma and plasma cell leukemia and Waldenström's macroglobulinemia (WM). In PCD the immune system is actively suppressed through the secretion of suppressive factors and the recruitment of immune suppressive subpopulations...
March 28, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29589833/anemia-associated-with-worse-outcome-in-diffuse-large-b-cell-lymphoma-patients-a-single-center-retrospective-study
#9
Kenji Matsumoto, Shin Fujisawa, Taiki Ando, Megumi Koyama, Satoshi Koyama, Yoshimi Ishii, Ayumi Numata, Wataru Yamamoto, Kenji Motohashi, Maki Hagihara, Hideaki Nakajima
No abstract text is available yet for this article.
March 28, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29589832/acute-traumatic-coagulopathy-the-value-of-histone-in-pediatric-trauma-patients
#10
Emel Ulusoy, Murat Duman, Aykut Çağlar, Tuncay Küme, Anıl Er, Fatma Akgül, Hale Çitlenbik, Durgül Yılmaz, Hale Ören
OBJECTIVE: Acute traumatic coagulopathy occurs after trauma with impairment of hemostasis and activation of fibrinolysis. Some endogenous substances may play role in this failure of the coagulation system. Extracellular histone is one such molecule that has recently attracted attention. This study investigated the association between plasma histone- complexed DNA (hcDNA) fragments and coagulation abnormalities in pediatric trauma patients. MATERIALS AND METHODS: This prospective case- control study was conducted in pediatric patients with trauma...
March 28, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29553461/recognizing-pinch-purpura-as-the-first-manifestation-of-al-amyloidosis
#11
Erman Öztürk, Meltem Olga Akay, Burhan Ferhanoğlu
No abstract text is available yet for this article.
March 19, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29545231/use-of-a-high-purity-factor-x-concentrate-in-turkish-subjects-with-hereditary-factor-x-deficiency-post-hoc-cohort-subanalysis-of-a-phase-3-study
#12
Ahmet F Oner, Tiraje Celkan, Çetin Timur, Miranda Norton, Kaan Kavaklı
Hereditary factor X (FX) deficiency is a rare bleeding disorder more prevalent in countries with high rates of consanguineous marriage. In a prospective, open-label, multicentre, phase 3 study, 25 IU/kg pdFX was administered as on-demand treatment or short-term prophylaxis for 6 months-2 years. In Turkish subjects (N=6), 60.7% of bleeds were minor. A mean of 1.03 infusions was used to treat each bleed, and mean total dose per bleed was 25.38 IU/kg. Turkish subjects ratedpdFX efficacy as excellent or good for all 84 assessable bleeds; investigators judged overall pdFX efficacy to be excellent or good in all subjects...
March 16, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29516854/glomerular-and-tubular-functions-in-transfusion-dependent-thalassemia
#13
Pathum Sookaromdee, Viroj Wiwanitkit
No abstract text is available yet for this article.
March 8, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29391340/effectiveness-of-ankaferd-bloodstopper-in-prophylaxis-and-treatment-of-oral-mucositis-in-childhood-cancers-evaluated-with-plasma-citrulline-levels
#14
Türkan Patıroğlu, Nagihan Erdoğ Şahin, Ekrem Ünal, Mustafa Kendirci, Musa Karakükcü, Mehmet Akif Özdemir
No abstract text is available yet for this article.
March 1, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29391338/expansion-of-a-myeloma-associated-lesion-from-orbita-to-the-cerebrum
#15
Sinan Demircioğlu, Demet Aydoğdu, Özcan Çeneli
No abstract text is available yet for this article.
March 1, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29391334/invasive-fungal-infections-in-patients-with-hematological-malignancies-emergence-of-resistant-pathogens-and-new-antifungal-therapies
#16
Maria N Gamaletsou, Thomas J Walsh, Nikolaos V Sipsas
Invasive fungal infections caused by drug-resistant organisms are an emerging threat to heavily immunosuppressed patients with hematological malignancies. Modern early antifungal treatment strategies, such as prophylaxis and empirical and preemptive therapy, result in long-term exposure to antifungal agents, which is a major driving force for the development of resistance. The extended use of central venous catheters, the nonlinear pharmacokinetics of certain antifungal agents, neutropenia, other forms of intense immunosuppression, and drug toxicities are other contributing factors...
March 1, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29391333/t-9-19-q22-p13-in-acute-myelomonocytic-leukemia
#17
Moeinadin Safavi, Akbar Safaei, Marzieh Hosseini
No abstract text is available yet for this article.
March 1, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29212626/a-lesser-known-side-effect-of-tigecycline-hypofibrinogenemia
#18
Fulya Yılmaz Duran, Halil Yıldırım, Emre Mehmet Şen
No abstract text is available yet for this article.
March 1, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29192604/leukoagglutination-mycoplasma-pneumoniae-pneumonia-and-edta-acid-blood
#19
Beuy Joob, Viroj Wiwanitkit
No abstract text is available yet for this article.
March 1, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29192603/cyclic-guanosine-monophosphate-dependent-protein-kinase-i-stimulators-and-activators-are-therapeutic-alternatives-for-sickle-cell-disease
#20
Mohankrishna Ghanta, Elango Panchanathan, Bhaskar Vks Lakkakula
No abstract text is available yet for this article.
March 1, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
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