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Lancet Diabetes & Endocrinology

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https://www.readbyqxmd.com/read/28629907/the-role-of-biosimilar-manufacturers-in-improving-access-to-insulin-globally
#1
LETTER
Christophe Perrin, Margaret Ewen, David Beran
No abstract text is available yet for this article.
June 16, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28615150/metformin-in-type-1-diabetes
#2
Eberhard Standl
No abstract text is available yet for this article.
June 9, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28615149/cardiovascular-and-metabolic-effects-of-metformin-in-patients-with-type-1-diabetes-removal-a-double-blind-randomised-placebo-controlled-trial
#3
John R Petrie, Nishi Chaturvedi, Ian Ford, Martijn C G J Brouwers, Nicola Greenlaw, Therese Tillin, Irene Hramiak, Alun D Hughes, Alicia J Jenkins, Barbara E K Klein, Ronald Klein, Teik C Ooi, Peter Rossing, Coen D A Stehouwer, Naveed Sattar, Helen M Colhoun
BACKGROUND: Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 diabetes, but whether it has cardiovascular benefits is unknown. We aimed to investigate whether metformin treatment (added to titrated insulin therapy) reduced atherosclerosis, as measured by progression of common carotid artery intima-media thickness (cIMT), in adults with type 1 diabetes at increased risk for cardiovascular disease. METHODS: REMOVAL was a double-blind, placebo-controlled trial undertaken at 23 hospital diabetes clinics in five countries (Australia, Canada, Denmark, the Netherlands, and the UK)...
June 9, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28606729/person-centred-type-2-diabetes-care-time-for-a-paradigm-shift
#4
Guy E H M Rutten, Aus Alzaid
No abstract text is available yet for this article.
June 9, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28602362/correction-to-lancet-diabetes-endocrinol-2017-published-online-june-7-http-dx-doi-org-10-1016-s2213-8587-17-30174-2
#5
(no author information available yet)
No abstract text is available yet for this article.
June 8, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28601585/prevalence-of-diabetes-and-prediabetes-in-15-states-of-india-results-from-the-icmr-indiab-population-based-cross-sectional-study
#6
Ranjit Mohan Anjana, Mohan Deepa, Rajendra Pradeepa, Jagadish Mahanta, Kanwar Narain, Hiranya Kumar Das, Prabha Adhikari, Paturi Vishnupriya Rao, Banshi Saboo, Ajay Kumar, Anil Bhansali, Mary John, Rosang Luaia, Taranga Reang, Somorjit Ningombam, Lobsang Jampa, Richard O Budnah, Nirmal Elangovan, Radhakrishnan Subashini, Ulagamathesan Venkatesan, Ranjit Unnikrishnan, Ashok Kumar Das, Sri Venkata Madhu, Mohammed K Ali, Arvind Pandey, Rupinder Singh Dhaliwal, Tanvir Kaur, Soumya Swaminathan, Viswanathan Mohan
BACKGROUND: Previous studies have not adequately captured the heterogeneous nature of the diabetes epidemic in India. The aim of the ongoing national Indian Council of Medical Research-INdia DIABetes study is to estimate the national prevalence of diabetes and prediabetes in India by estimating the prevalence by state. METHODS: We used a stratified multistage design to obtain a community-based sample of 57 117 individuals aged 20 years or older. The sample population represented 14 of India's 28 states (eight from the mainland and six from the northeast of the country) and one union territory...
June 7, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28601583/should-we-officially-recognise-obesity-as-a-disease
#7
EDITORIAL
The Lancet Diabetes Endocrinology
No abstract text is available yet for this article.
June 7, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28601582/research-digest-topical-trials-in-thyroid-disease
#8
David Preiss, Steve Cleland, Naveed Sattar
No abstract text is available yet for this article.
June 7, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28601584/the-need-for-improved-diabetes-care-in-india
#9
Vijay Viswanathan
No abstract text is available yet for this article.
June 6, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28576688/rating-the-blood-pressure-outcome-after-adrenalectomy-for-unilateral-primary-aldosteronism
#10
Olivier Steichen
No abstract text is available yet for this article.
May 30, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28576687/outcomes-after-adrenalectomy-for-unilateral-primary-aldosteronism-an-international-consensus-on-outcome-measures-and-analysis-of-remission-rates-in-an-international-cohort
#11
Tracy A Williams, Jacques W M Lenders, Paolo Mulatero, Jacopo Burrello, Marietta Rottenkolber, Christian Adolf, Fumitoshi Satoh, Laurence Amar, Marcus Quinkler, Jaap Deinum, Felix Beuschlein, Kanako K Kitamoto, Uyen Pham, Ryo Morimoto, Hironobu Umakoshi, Aleksander Prejbisz, Tomaz Kocjan, Mitsuhide Naruse, Michael Stowasser, Tetsuo Nishikawa, William F Young, Celso E Gomez-Sanchez, John W Funder, Martin Reincke
BACKGROUND: Although unilateral primary aldosteronism is the most common surgically correctable cause of hypertension, no standard criteria exist to classify surgical outcomes. We aimed to create consensus criteria for clinical and biochemical outcomes and follow-up of adrenalectomy for unilateral primary aldosteronism and apply these criteria to an international cohort to analyse the frequency of remission and identify preoperative determinants of successful outcome. METHODS: The Primary Aldosteronism Surgical Outcome (PASO) study was an international project to develop consensus criteria for outcomes and follow-up of adrenalectomy for unilateral primary aldosteronism...
May 30, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28566219/lipoprotein-a-and-cardiovascular-mortality-mystery-still-unsolved
#12
Raul D Santos
No abstract text is available yet for this article.
May 26, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28566218/relations-between-lipoprotein-a-concentrations-lpa-genetic-variants-and-the-risk-of-mortality-in-patients-with-established-coronary-heart-disease-a-molecular-and-genetic-association-study
#13
Stephen Zewinger, Marcus E Kleber, Vinicius Tragante, Raymond O McCubrey, Amand F Schmidt, Kenan Direk, Ulrich Laufs, Christian Werner, Wolfgang Koenig, Dietrich Rothenbacher, Ute Mons, Lutz P Breitling, Herrmann Brenner, Richard T Jennings, Ioannis Petrakis, Sarah Triem, Mira Klug, Alexandra Filips, Stefan Blankenberg, Christoph Waldeyer, Christoph Sinning, Renate B Schnabel, Karl J Lackner, Efthymia Vlachopoulou, Ottar Nygård, Gard Frodahl Tveitevåg Svingen, Eva Ringdal Pedersen, Grethe S Tell, Juha Sinisalo, Markku S Nieminen, Reijo Laaksonen, Stella Trompet, Roelof A J Smit, Naveed Sattar, J Wouter Jukema, Heinrich V Groesdonk, Graciela Delgado, Tatjana Stojakovic, Anna P Pilbrow, Vicky A Cameron, A Mark Richards, Robert N Doughty, Yan Gong, Rhonda Cooper-DeHoff, Julie Johnson, Markus Scholz, Frank Beutner, Joachim Thiery, J Gustav Smith, Ragnar O Vilmundarson, Ruth McPherson, Alexandre F R Stewart, Sharon Cresci, Petra A Lenzini, John A Spertus, Oliviero Olivieri, Domenico Girelli, Nicola I Martinelli, Andreas Leiherer, Christoph H Saely, Heinz Drexel, Axel Mündlein, Peter S Braund, Christopher P Nelson, Nilesh J Samani, Daniel Kofink, Imo E Hoefer, Gerard Pasterkamp, Arshed A Quyyumi, Yi-An Ko, Jaana A Hartiala, Hooman Allayee, W H Wilson Tang, Stanley L Hazen, Niclas Eriksson, Claes Held, Emil Hagström, Lars Wallentin, Axel Åkerblom, Agneta Siegbahn, Igor Karp, Christopher Labos, Louise Pilote, James C Engert, James M Brophy, George Thanassoulis, Peter Bogaty, Wojciech Szczeklik, Marcin Kaczor, Marek Sanak, Salim S Virani, Christie M Ballantyne, Vei-Vei Lee, Eric Boerwinkle, Michael V Holmes, Benjamin D Horne, Aroon Hingorani, Folkert W Asselbergs, Riyaz S Patel, Bernhard K Krämer, Hubert Scharnagl, Danilo Fliser, Winfried März, Thimoteus Speer
BACKGROUND: Lipoprotein(a) concentrations in plasma are associated with cardiovascular risk in the general population. Whether lipoprotein(a) concentrations or LPA genetic variants predict long-term mortality in patients with established coronary heart disease remains less clear. METHODS: We obtained data from 3313 patients with established coronary heart disease in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. We tested associations of tertiles of lipoprotein(a) concentration in plasma and two LPA single-nucleotide polymorphisms ([SNPs] rs10455872 and rs3798220) with all-cause mortality and cardiovascular mortality by Cox regression analysis and with severity of disease by generalised linear modelling, with and without adjustment for age, sex, diabetes diagnosis, systolic blood pressure, BMI, smoking status, estimated glomerular filtration rate, LDL-cholesterol concentration, and use of lipid-lowering therapy...
May 26, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28546097/10-years-of-denosumab-treatment-in-postmenopausal-women-with-osteoporosis-results-from-the-phase-3-randomised-freedom-trial-and-open-label-extension
#14
Henry G Bone, Rachel B Wagman, Maria L Brandi, Jacques P Brown, Roland Chapurlat, Steven R Cummings, Edward Czerwiński, Astrid Fahrleitner-Pammer, David L Kendler, Kurt Lippuner, Jean-Yves Reginster, Christian Roux, Jorge Malouf, Michelle N Bradley, Nadia S Daizadeh, Andrea Wang, Paula Dakin, Nicola Pannacciulli, David W Dempster, Socrates Papapoulos
BACKGROUND: Long-term safety and efficacy of osteoporosis treatment are important because of the chronic nature of the disease. We aimed to assess the long-term safety and efficacy of denosumab, which is widely used for the treatment of postmenopausal women with osteoporosis. METHODS: In the multicentre, randomised, double-blind, placebo-controlled, phase 3 FREEDOM trial, postmenopausal women aged 60-90 years with osteoporosis were enrolled in 214 centres in North America, Europe, Latin America, and Australasia and were randomly assigned (1:1) to receive 60 mg subcutaneous denosumab or placebo every 6 months for 3 years...
May 22, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28546096/bone-disease-in-diabetes-another-manifestation-of-microvascular-disease
#15
REVIEW
Vikram V Shanbhogue, Stinus Hansen, Morten Frost, Kim Brixen, Anne P Hermann
Type 1 and type 2 diabetes are generally accepted to be associated with increased bone fracture risk. However, the pathophysiological mechanisms of diabetic bone disease are poorly understood, and whether the associated increased skeletal fragility is a comorbidity or a complication of diabetes remains under debate. Although there is some indication of a direct deleterious effect of microangiopathy on bone, the evidence is open to question, and whether diabetic osteopathy can be classified as a chronic, microvascular complication of diabetes remains uncertain...
May 22, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28546095/puberty-suppression-in-transgender-children-and-adolescents
#16
REVIEW
Simone Mahfouda, Julia K Moore, Aris Siafarikas, Florian D Zepf, Ashleigh Lin
The World Professional Association for Transgender Health's standards of care recommend suspending puberty, preferably with the use of gonadotropin-releasing hormone agonists, in certain gender non-conforming minors (aged under 18 years) who have undergone a psychiatric assessment and have reached at least Tanner stage II of puberty. This approach seeks to lessen the discordance between assigned natal sex and gender identity by temporarily halting the development of secondary sexual characteristics, essentially widening the temporal window for gender clarification...
May 22, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28546094/safety-of-long-term-denosumab-therapy-for-osteoporosis
#17
Juliet Compston
No abstract text is available yet for this article.
May 22, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28533139/artificial-pancreas-research-you-can-observe-a-lot-by-watching
#18
Steven J Russell
No abstract text is available yet for this article.
May 19, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28533138/exercise-and-physical-activity-in-patients-with-type-1-diabetes-authors-reply
#19
LETTER
Michael C Riddell, Ian W Gallen, Remi Rabasa-Lhoret
No abstract text is available yet for this article.
May 19, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28533137/exercise-and-physical-activity-in-patients-with-type-1-diabetes
#20
LETTER
Matthew D Campbell, Nicola Kime, James McKenna
No abstract text is available yet for this article.
May 19, 2017: Lancet Diabetes & Endocrinology
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