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Lancet Diabetes & Endocrinology

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https://www.readbyqxmd.com/read/27916515/oestrogen-and-anti-androgen-therapy-for-transgender-women
#1
REVIEW
Vin Tangpricha, Martin den Heijer
Transgender women experience lifelong gender dysphoria due to a gender assignment at birth that is incongruent with their gender identity. They often seek hormone therapy, with or without surgery, to improve their gender dysphoria and to better align their physical and psychological features with a more feminine gender role. Some of the desired physical changes from oestrogen and anti-androgen therapy include decreased body and facial hair, decreased muscle mass, breast growth, and redistribution of fat. Overall the risks of treatment are low, but include thromboembolism, the risk of which depends on the dose and route of oestrogen administration...
December 1, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27915035/hyperinsulinaemic-hypoglycaemia-in-children-and-adults
#2
REVIEW
Pratik Shah, Sofia A Rahman, Huseyin Demirbilek, Maria Güemes, Khalid Hussain
Pancreatic β cells are functionally programmed to release insulin in response to changes in plasma glucose concentration. Insulin secretion is precisely regulated so that, under normal physiological conditions, fasting plasma glucose concentrations are kept within a narrow range of 3·5-5·5 mmol/L. In hyperinsulinaemic hypoglycaemia, insulin secretion becomes dysregulated (ie, uncoupled from glucose metabolism) so that insulin secretion persists in the presence of low plasma glucose concentrations. Hyperinsulinaemic hypoglycaemia is the most common cause of severe and persistent hypoglycaemia in neonates and children...
November 30, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27913173/hacking-diabetes-diy-artificial-pancreas-systems
#3
Conor Farrington
No abstract text is available yet for this article.
November 29, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27908689/pcsk9-genetic-variants-and-risk-of-type-2-diabetes-a-mendelian-randomisation-study
#4
Amand F Schmidt, Daniel I Swerdlow, Michael V Holmes, Riyaz S Patel, Zammy Fairhurst-Hunter, Donald M Lyall, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hyppönen, Christine Power, Max Moldovan, Erik van Iperen, G Kees Hovingh, Ilja Demuth, Kristina Norman, Elisabeth Steinhagen-Thiessen, Juri Demuth, Lars Bertram, Tian Liu, Stefan Coassin, Johann Willeit, Stefan Kiechl, Karin Willeit, Dan Mason, John Wright, Richard Morris, Goya Wanamethee, Peter Whincup, Yoav Ben-Shlomo, Stela McLachlan, Jackie F Price, Mika Kivimaki, Catherine Welch, Adelaida Sanchez-Galvez, Pedro Marques-Vidal, Andrew Nicolaides, Andrie G Panayiotou, N Charlotte Onland-Moret, Yvonne T van der Schouw, Giuseppe Matullo, Giovanni Fiorito, Simonetta Guarrera, Carlotta Sacerdote, Nicholas J Wareham, Claudia Langenberg, Robert Scott, Jian'an Luan, Martin Bobak, Sofia Malyutina, Andrzej Pająk, Ruzena Kubinova, Abdonas Tamosiunas, Hynek Pikhart, Lise Lotte Nystrup Husemoen, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Kenneth Starup Simonsen, Jackie Cooper, Steve E Humphries, Murray Brilliant, Terrie Kitchner, Hakon Hakonarson, David S Carrell, Catherine A McCarty, H Lester Kirchner, Eric B Larson, David R Crosslin, Mariza de Andrade, Dan M Roden, Joshua C Denny, Cara Carty, Stephen Hancock, John Attia, Elizabeth Holliday, Martin O' Donnell, Salim Yusuf, Michael Chong, Guillaume Pare, Pim van der Harst, M Abdullah Said, Ruben N Eppinga, Niek Verweij, Harold Snieder, Tim Christen, Dennis O Mook-Kanamori, Stefan Gustafsson, Lars Lind, Erik Ingelsson, Raha Pazoki, Oscar Franco, Albert Hofman, Andre Uitterlinden, Abbas Dehghan, Alexander Teumer, Sebastian Baumeister, Marcus Dörr, Markus M Lerch, Uwe Völker, Henry Völzke, Joey Ward, Jill P Pell, Daniel J Smith, Tom Meade, Anke H Maitland-van der Zee, Ekaterina V Baranova, Robin Young, Ian Ford, Archie Campbell, Sandosh Padmanabhan, Michiel L Bots, Diederick E Grobbee, Philippe Froguel, Dorothée Thuillier, Beverley Balkau, Amélie Bonnefond, Bertrand Cariou, Melissa Smart, Yanchun Bao, Meena Kumari, Anubha Mahajan, Paul M Ridker, Daniel I Chasman, Alex P Reiner, Leslie A Lange, Marylyn D Ritchie, Folkert W Asselbergs, Juan-Pablo Casas, Brendan J Keating, David Preiss, Aroon D Hingorani, Naveed Sattar
BACKGROUND: Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk...
November 28, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27890485/nizar-albache-championing-the-cause-of-syrian-refugees-with-diabetes
#5
Jennifer Thorley
No abstract text is available yet for this article.
November 24, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27865757/guilt-or-guilt-by-association-insulin-therapy-in-type-2-diabetes-and-death
#6
Amanda I Adler
No abstract text is available yet for this article.
November 16, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27865756/association-of-insulin-dosage-with-mortality-or-major-adverse-cardiovascular-events-a-retrospective-cohort-study
#7
John-Michael Gamble, Eugene Chibrikov, Laurie K Twells, William K Midodzi, Stephanie W Young, Don MacDonald, Sumit R Majumdar
BACKGROUND: Existing studies have shown conflicting evidence regarding the safety of exogenous insulin therapy in patients with type 2 diabetes. In particular, observational studies have reported an increased risk of death and cardiovascular disease among users of higher versus lower doses of insulin. We aimed to quantify the association between increasing dosage of insulin exposure and death and cardiovascular events, while taking into account time-dependent confounding and mediation that might have biased previous studies...
November 16, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27863980/the-need-for-international-consensus-on-prediabetes
#8
Lydia E Makaroff
No abstract text is available yet for this article.
November 15, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27863979/comparative-prognostic-performance-of-definitions-of-prediabetes-a-prospective-cohort-analysis-of-the-atherosclerosis-risk-in-communities-aric-study
#9
Bethany Warren, James S Pankow, Kunihiro Matsushita, Naresh M Punjabi, Natalie R Daya, Morgan Grams, Mark Woodward, Elizabeth Selvin
BACKGROUND: No consensus on definitions of prediabetes exists among international organisations. Analysis of associations with different definitions and clinical complications can inform the comparative value of different prediabetes definitions. We compared the risk of future outcomes across different prediabetes definitions based on fasting glucose concentration, HbA1c, and 2 h glucose concentration during over two decades of follow-up in the community-based Atherosclerosis Risk in Communities (ARIC) study...
November 15, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27836235/closed-loop-insulin-delivery-in-inpatients-with-type-2-diabetes-a-randomised-parallel-group-trial
#10
Hood Thabit, Sara Hartnell, Janet M Allen, Andrea Lake, Malgorzata E Wilinska, Yue Ruan, Mark L Evans, Anthony P Coll, Roman Hovorka
BACKGROUND: We assessed whether fully closed-loop insulin delivery (the so-called artificial pancreas) is safe and effective compared with standard subcutaneous insulin therapy in patients with type 2 diabetes in the general ward. METHODS: For this single-centre, open-label, parallel-group, randomised controlled trial, we enrolled patients aged 18 years or older with type 2 diabetes who were receiving insulin therapy. Patients were recruited from general wards at Addenbrooke's Hospital, Cambridge, UK...
November 8, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27836233/closer-to-closing-the-loop-on-inpatient-glycaemia
#11
Gerry Rayman
No abstract text is available yet for this article.
November 8, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27818210/neuroendocrine-tumours-emerge-from-the-shadows
#12
Judith A Gilbert
No abstract text is available yet for this article.
November 3, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27815093/antibiotics-infections-and-childhood-obesity
#13
Christopher B Forrest, Jason P Block, L Charles Bailey
No abstract text is available yet for this article.
November 1, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27815092/alafia-samuels-fast-food-watchdog-in-the-caribbean
#14
Ray Cavanaugh
No abstract text is available yet for this article.
November 1, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27815091/infection-and-antibiotic-use-in-infancy-and-risk-of-childhood-obesity-a-longitudinal-birth-cohort-study
#15
De-Kun Li, Hong Chen, Jeannette Ferber, Roxana Odouli
BACKGROUND: Data from previous studies have suggested a possible association between antibiotic use in infancy and risk of childhood obesity, with implications for health-care delivery and obesity prevention strategies. However, whether the observed association was due to antibiotic use or underlying infection, or both, is unclear. We aimed to disentangle the effect of antibiotic use in infancy from that of underlying infection on the risk of childhood obesity. METHODS: In this longitudinal birth cohort study, we included infants in the Kaiser Permanente Northern California population born between Jan 1, 1997, and March 31, 2013...
November 1, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27773653/leveraging-the-immune-system-to-treat-advanced-thyroid-cancers
#16
Jena D French, Keith Bible, Christine Spitzweg, Bryan R Haugen, Mabel Ryder
Inflammation has long been associated with the thyroid and with thyroid cancers, raising seminal questions about the role of the immune system in the pathogenesis of advanced thyroid cancers. With a growing understanding of dynamic tumour-immune cell interactions and the mechanisms by which tumour cells evade antitumour immunity, the field of cancer immunotherapy has been revolutionised. In this Review, we provide evidence to support the presence of an antitumour immune response in advanced thyroid cancers linked to cytotoxic T cells and NK cells...
October 20, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27745849/black-and-white-autoimmunity-early-warning-colours-of-adrenal-crisis
#17
Thomas Cuny, Marc Klein
No abstract text is available yet for this article.
October 10, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27743978/influence-of-maternal-obesity-on-the-long-term-health-of-offspring
#18
Keith M Godfrey, Rebecca M Reynolds, Susan L Prescott, Moffat Nyirenda, Vincent W V Jaddoe, Johan G Eriksson, Birit F P Broekman
In addition to immediate implications for pregnancy complications, increasing evidence implicates maternal obesity as a major determinant of offspring health during childhood and later adult life. Observational studies provide evidence for effects of maternal obesity on her offspring's risks of obesity, coronary heart disease, stroke, type 2 diabetes, and asthma. Maternal obesity could also lead to poorer cognitive performance and increased risk of neurodevelopmental disorders, including cerebral palsy. Preliminary evidence suggests potential implications for immune and infectious-disease-related outcomes...
October 10, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27743974/interventions-to-prevent-maternal-obesity-before-conception-during-pregnancy-and-post-partum
#19
Mark Hanson, Mary Barker, Jodie M Dodd, Shiriki Kumanyika, Shane Norris, Eric Steegers, Judith Stephenson, Shakila Thangaratinam, Huixia Yang
Prevention of obesity in women of reproductive age is widely recognised to be important both for their health and for that of their offspring. Weight-control interventions, including drug treatment, in pregnant women who are obese or overweight have not had sufficient impact on pregnancy and birth outcomes, which suggests that the focus for intervention should include preconception or post-partum periods. Further research is needed into the long-term effects of nutritional and lifestyle interventions before conception...
October 10, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27720352/pablo-perel-leading-improvements-in-global-cardiovascular-health
#20
Fiona Mitchell
No abstract text is available yet for this article.
October 5, 2016: Lancet Diabetes & Endocrinology
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