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Lancet Diabetes & Endocrinology

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https://www.readbyqxmd.com/read/30413396/efficacy-of-a-novel-inhibitor-of-vascular-adhesion-protein-1-in-reducing-albuminuria-in-patients-with-diabetic-kidney-disease-album-a-randomised-placebo-controlled-phase-2-trial
#1
Dick de Zeeuw, Ronny W Renfurm, George Bakris, Peter Rossing, Vlado Perkovic, Fan Fan Hou, Masaomi Nangaku, Kumar Sharma, Hiddo J L Heerspink, Alberto Garcia-Hernandez, Tobias E Larsson
BACKGROUND: Many patients with diabetic kidney disease have residual albuminuria and are at risk of disease progression. The ALBUM trial investigated the efficacy of a novel, orally active inhibitor of vascular adhesion protein-1, ASP8232, compared with placebo for reducing albuminuria in individuals with type 2 diabetes and chronic kidney disease. METHODS: In this randomised, double-blind, placebo-controlled phase 2 trial, we randomly assigned individuals (aged 18-85 years) from 64 clinical sites in nine European countries to receive ASP8232 40 mg or placebo orally once daily for 12 weeks using a web-based randomisation schedule (block size 4), stratified by country...
November 6, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30413395/emerging-paradigms-of-treating-diabetic-nephropathy
#2
Yongen Chang, Hamid Moradi, Kamyar Kalantar-Zadeh
No abstract text is available yet for this article.
November 6, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30396866/the-perils-of-polyvascular-disease-in-type-2-diabetes
#3
Subodh Verma, C David Mazer, Deepak L Bhatt
No abstract text is available yet for this article.
November 2, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30396865/polyvascular-disease-type-2-diabetes-and-long-term-vascular-risk-a-secondary-analysis-of-the-improve-it-trial
#4
Marc P Bonaca, J Antonio Gutierrez, Christopher Cannon, Robert Giugliano, Michael Blazing, Jeong-Gun Park, Jennifer White, Andrew Tershakovec, Eugene Braunwald
BACKGROUND: Polyvascular disease and type 2 diabetes are each associated with increased cardiovascular risk, but whether these risks are additive is unknown. In this exploratory analysis of a randomised trial, we explored the long-term cardiovascular risk associated with polyvascular disease, type 2 diabetes, and their combination in patients with acute coronary syndrome, and assessed the effect of ezetimibe given on top of statin therapy in patients with these concomitant conditions...
November 2, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30389323/association-of-bmi-with-overall-and-cause-specific-mortality-a-population-based-cohort-study-of-3%C3%A2-6-million-adults-in-the-uk
#5
Krishnan Bhaskaran, Isabel Dos-Santos-Silva, David A Leon, Ian J Douglas, Liam Smeeth
BACKGROUND: BMI is known to be strongly associated with all-cause mortality, but few studies have been large enough to reliably examine associations between BMI and a comprehensive range of cause-specific mortality outcomes. METHODS: In this population-based cohort study, we used UK primary care data from the Clinical Practice Research Datalink (CPRD) linked to national mortality registration data and fitted adjusted Cox regression models to examine associations between BMI and all-cause mortality, and between BMI and a comprehensive range of cause-specific mortality outcomes (recorded by International Classification of Diseases, 10th revision [ICD-10] codes)...
October 30, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30389322/the-association-between-bmi-and-mortality-implications-for-obesity-prevention
#6
Deirdre K Tobias, Frank B Hu
No abstract text is available yet for this article.
October 30, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30287104/public-health-and-health-systems-implications-for-the-prevention-and-management-of-type-2-diabetes-in-south-asia
#7
REVIEW
Andrew P Hills, Anoop Misra, Jason M R Gill, Nuala M Byrne, Mario J Soares, Ambady Ramachandran, Latha Palaniappan, Steven J Street, Ranil Jayawardena, Kamlesh Khunti, Ross Arena
Many non-communicable chronic diseases, including type 2 diabetes, are highly prevalent, costly, and largely preventable. The prevention and management of type 2 diabetes in south Asia requires a combination of lifestyle changes and long-term health-care management. However, public health and health-care systems in south Asian countries face serious challenges, including the need to provide services to many people with inadequate resources, and substantial between-population and within-population inequalities...
October 1, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30287103/clinical-management-of-type-2-diabetes-in-south-asia
#8
REVIEW
Anoop Misra, Naveed Sattar, Nikhil Tandon, Usha Shrivastava, Naval K Vikram, Kamlesh Khunti, Andrew P Hills
Compared with other ethnic groups, south Asian people with type 2 diabetes tend to develop the disease at a younger age and manifest with higher glycaemia, dyslipidaemia, nephropathy, and cardiovascular diseases. Additionally, specific issues that can affect treatment of type 2 diabetes in south Asia include poor awareness of the disease, delay in diagnosis, inadequate treatment, the use of ineffective and often harmful alternative medicines, and frequent non-compliance with lifestyle recommendations and drug treatment...
October 1, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30287102/epidemiology-and-determinants-of-type-2-diabetes-in-south-asia
#9
REVIEW
Andrew P Hills, Ross Arena, Kamlesh Khunti, Chittaranjan Sakerlal Yajnik, Ranil Jayawardena, Christiani Jeyakumar Henry, Steven J Street, Mario J Soares, Anoop Misra
Type 2 diabetes has rapidly developed into a major public health problem in south Asia (defined here as Bangladesh, Bhutan, India, Nepal, Pakistan, and Sri Lanka) in recent decades. During this period, major lifestyle changes associated with economic transition, industrialisation, urbanisation, and globalisation have been key determinants in the increasing burden of non-communicable diseases. A decline in nutrition quality, reduced physical activity, and increased sedentary behaviours are reflected in the increasing prevalence of type 2 diabetes and related risk factors in the region...
October 1, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30224285/real-world-diabetes-prevention-from-theory-to-practice
#10
Robert E J Ryder
No abstract text is available yet for this article.
September 13, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30174213/non-alcoholic-fatty-liver-disease-causes-diagnosis-cardiometabolic-consequences-and-treatment-strategies
#11
REVIEW
Norbert Stefan, Hans-Ulrich Häring, Kenneth Cusi
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. In some patients with NAFLD, isolated steatosis can progress to advanced stages with non-alcoholic steatohepatitis (NASH) and fibrosis, increasing the risk of cirrhosis and hepatocellular carcinoma. Furthermore, NAFLD is believed to be involved in the pathogenesis of common disorders such as type 2 diabetes and cardiovascular disease. In this Review, we highlight novel concepts related to diagnosis, risk prediction, and treatment of NAFLD...
August 30, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30174212/correction-to-lancet-diabetes-endocrinol-2018-published-online-july-30-https-doi-org-10-1016-s2213-8587-18-30074-3
#12
(no author information available yet)
No abstract text is available yet for this article.
August 30, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30170949/availability-and-affordability-of-essential-medicines-for-diabetes-across-high-income-middle-income-and-low-income-countries-a-prospective-epidemiological-study
#13
Clara K Chow, Chinthanie Ramasundarahettige, Weihong Hu, Khalid F AlHabib, Alvaro Avezum, Xiaoru Cheng, Jephat Chifamba, Gilles Dagenais, Antonio Dans, Bonaventure A Egbujie, Rajeev Gupta, Romaina Iqbal, Noorhassim Ismail, Mirac V Keskinler, Rasha Khatib, Lanthé Kruger, Rajesh Kumar, Fernando Lanas, Scott Lear, Patricio Lopez-Jaramillo, Martin McKee, Noushin Mohammadifard, Viswanathan Mohan, Prem Mony, Andres Orlandini, Annika Rosengren, Krishnapillai Vijayakumar, Li Wei, Karen Yeates, Khalid Yusoff, Rita Yusuf, Afzalhussein Yusufali, Katarzyna Zatonska, Yihong Zhou, Shariful Islam, Daniel Corsi, Sumathy Rangarajan, Koon Teo, Hertzel C Gerstein, Salim Yusuf
BACKGROUND: Data are scarce on the availability and affordability of essential medicines for diabetes. Our aim was to examine the availability and affordability of metformin, sulfonylureas, and insulin across multiple regions of the world and explore the effect of these on medicine use. METHODS: In the Prospective Urban Rural Epidemiology (PURE) study, participants aged 35-70 years (n=156 625) were recruited from 110 803 households, in 604 communities and 22 countries; availability (presence of any dose of medication in the pharmacy on the day of audit) and medicine cost data were collected from pharmacies with the Environmental Profile of a Community's Health audit tool...
August 28, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30170948/availability-and-affordability-of-medicines-towards-an-evidence-base-for-routine-assessment
#14
Alessandra Ferrario
No abstract text is available yet for this article.
August 28, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30146449/preoperative-hyperglycaemia-and-risk-of-myocardial-injury-after-non-cardiac-surgery
#15
Arnold C T Ng, Jeroen J Bax
No abstract text is available yet for this article.
August 23, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30366567/effect-of-testosterone-replacement-on-measures-of-mobility-in-older-men-with-mobility-limitation-and-low-testosterone-concentrations-secondary-analyses-of-the-testosterone-trials
#16
Shalender Bhasin, Susan S Ellenberg, Thomas W Storer, Shehzad Basaria, Marco Pahor, Alisa J Stephens-Shields, Jane A Cauley, Kristine E Ensrud, John T Farrar, David Cella, Alvin M Matsumoto, Glenn R Cunningham, Ronald S Swerdloff, Christina Wang, Cora E Lewis, Mark E Molitch, Elizabeth Barrett-Connor, Jill P Crandall, Xiaoling Hou, Peter Preston, Denise Cifelli, Peter J Snyder, Thomas M Gill
BACKGROUND: The Physical Function Trial (PFT) was one of seven Testosterone Trials (TTrials), the aim of which was to assess the effect of testosterone on mobility, self-reported physical function, falls, and patient global impression-of-change (PGIC) in older men with low testosterone concentrations, self-reported mobility limitation, and walking speed of less than 1·2 m/s. Using data from the PFT and the overall TTrials study population, we also aimed to identify whether the effect of testosterone on mobility differed according to baseline walking speed, mobility limitation, or other participant-level factors...
November 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30366565/testosterone-therapy-and-physical-function
#17
Bradley D Anawalt, Stephanie T Page
No abstract text is available yet for this article.
November 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30322720/osteoporosis-a-roadmap-to-close-the-treatment-gap
#18
EDITORIAL
The Lancet Diabetes Endocrinology
No abstract text is available yet for this article.
November 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30293910/vitamin-d-and-bone-density-fractures-and-falls-the-end-of-the-story
#19
J Chris Gallagher
No abstract text is available yet for this article.
November 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/30293909/effects-of-vitamin-d-supplementation-on-musculoskeletal-health-a-systematic-review-meta-analysis-and-trial-sequential-analysis
#20
Mark J Bolland, Andrew Grey, Alison Avenell
BACKGROUND: The effects of vitamin D on fractures, falls, and bone mineral density are uncertain, particularly for high vitamin D doses. We aimed to determine the effect of vitamin D supplementation on fractures, falls, and bone density. METHODS: In this systematic review, random-effects meta-analysis, and trial sequential analysis, we used findings from literature searches in previously published meta-analyses. We updated these findings by searching PubMed, Embase, and Cochrane Central on Sept 14, 2017, and Feb 26, 2018, using the search term "vitamin D" and additional keywords, without any language restrictions...
November 2018: Lancet Diabetes & Endocrinology
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