Ran You, Francesco J DeMayo, Jian Liu, Sung-Nam Cho, Bryan M Burt, Chad J Creighton, Roberto F Casal, Donald R Lazarus, Wen Lu, Hui-Ying Tung, Xiaoyi Yuan, Andrea A Hill, Myunghoo Kim, Sarah Perusich, Lorraine D Cornwell, Daniel Rosen, Li-Zhen Song, Silke Paust, Gretchen E Diehl, David B Corry, Farrah Kheradmand
Somatic mutations can promote malignant transformation of airway epithelial cells, and induce inflammatory responses directed against resultant tumors. Tumor-infiltrating T lymphocytes (TILs) in early stage non-small cell lung cancer (NSCLC) secrete distinct pro-inflammatory cytokines, but the contribution of these TILs to tumor development and metastasis remains unknown. We show here that TILs in early stage NSCLC are biased toward IL17A expression (Th17) when compared to adjacent tumor-free tissue, whereas Th17 cells are decreased in tumor infiltrating loco-regional lymph nodes in advanced NSCLC...
April 13, 2018: Cancer Immunology Research