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Clinical Medicine Insights. Ear, Nose and Throat

Maria K Peltola, Joel S Lehikoinen, Lauri T Sippola, Kauko Saarilahti, Antti A Mäkitie
INTRODUCTION: The patient's role in toxicity reporting is increasingly acknowledged. There is also a need for developing modern communication methods between the patient and the medical personnel. Furthermore, the increasing number of head and neck cancer (HNC) patients is reflected in the volume of treatment follow-up visits, which remains a challenge for the health care. Electronic patient-reported outcome (ePRO) measures may provide a cost-efficient way to organize follow-up for cancer patients...
2016: Clinical Medicine Insights. Ear, Nose and Throat
Cinzia L Marchica, Issam Saliba
OBJECTIVES: To identify whether measurement of the prosthesis length is mandatory in patients requiring otosclerosis surgeries and to assess their postoperative audiometric outcomes. In addition, evaluation of prosthesis length used in revision compared to primary stapedectomy was carried out. STUDY DESIGN: Case series with chart review. METHODS: Chart review of 393 patients undergoing primary (321) versus revision stapedectomy (72) was performed in a tertiary referral center...
2015: Clinical Medicine Insights. Ear, Nose and Throat
Catherine Wanjiru Irungu, Herbert O Oburra, Betha Ochola
We assessed the prevalence and predictors of malnutrition in patients with nasopharyngeal carcinoma. Sixty cases and 123 controls matched for age and gender were included. Bio-data, dietary history, height, weight, body mass index (BMI), ideal body weight, and serum albumin levels were recorded. Pretreatment weight loss of >5% was present in 35% of subjects (P < 0.0001). A BMI of < 18.5 kg/m(2) was present in 13.3% (P < 0.001), percent ideal body weight of <90% was present in 30% (P < 0.001), and serum albumin levels <30 g/dL was present in 23...
2015: Clinical Medicine Insights. Ear, Nose and Throat
Karin Blomgren, Lotta Eliander, Maija Hytönen, Suvi Ylinen, Mirja Laitio, Paula Virkkula
BACKGROUND: Antral irrigation earlier had an important role in the diagnosis and treatment of rhinosinusitis. Nowadays, it is often considered too unpleasant. However, the experience of patients of this procedure has been very seldom evaluated. Nor has the effect on pain in rhinosinusitis been evaluated. The aim of this study was to evaluate patients' experience of discomfort and pain during antral irrigation. We also assessed facial pain caused by rhinosinusitis before the procedure and pain soon after the procedure...
2015: Clinical Medicine Insights. Ear, Nose and Throat
Paula Virkkula, Antti A Mäkitie, Seija I Vento
AIMS: Surgical treatment of nasal septal perforation remains a challenging field of rhinology. A large variety of techniques and grafts with promising results have been introduced for perforation repair. However, the use of fascia or fascia with periosteum has not been previously evaluated for a large sample of patients. METHODS: During the years 2007-2014, 105 operations were performed and 98 patients were treated for nasal septal perforation at the Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, Helsinki, Finland...
2015: Clinical Medicine Insights. Ear, Nose and Throat
Ismail Zohdi, Louay S El Sharkawy, Mahmoud F El Bestar, Hazem M Abdel Tawab, Mo'men Aa Hamela, Amal A Hareedy
OBJECTIVES: To evaluate the effectiveness of selective neck dissection of sublevel IIa and level III in cases of glottis and supraglottic laryngeal carcinoma in the absence of lymph node metastasis and to show if there is value in dissecting the sublevel IIb or level IV in these cases. PATIENTS AND METHODS: Twenty-five patients with N0 glottic or supraglottic cancer were subjected to unilateral or bilateral selective neck dissection according to the site and the extent of the tumor, and the specimens were histopathologically examined for metastasis...
2015: Clinical Medicine Insights. Ear, Nose and Throat
Patorn Piromchai, Sanguansak Thanaviratananich
BACKGROUND: Invasive fungal rhinosinusitis is an uncommon disease with high mortality rates. There is currently no consensus on the best treatment timing. We studied the impact of the treatment timing on the survival of patients experiencing invasive fungal rhinosinusitis. METHODS: We conducted a retrospective study of patients suffering from invasive fungal rhinosinusitis. The duration of symptoms, clinical presentations, clinical signs, diagnoses, treatments, and outcomes were collected...
2014: Clinical Medicine Insights. Ear, Nose and Throat
Harri Keski-Säntti, Timo Mustonen, Jukka Schildt, Kauko Saarilahti, Antti A Mäkitie
BACKGROUND: In many centers, (18)F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is used to monitor treatment response after definitive (chemo)radiotherapy [(C)RT] for head and neck squamous cell carcinoma (HNSCC), but its usefulness remains somewhat controversial. We aimed at assessing the accuracy of FDG-PET/CT in detecting residual disease after (C)RT. METHOD: All HNSCC patients with FDG-PET/CT performed to assess treatment response 10-18 weeks after definitive (C)RT at our institution during 2008-2010 were included...
2014: Clinical Medicine Insights. Ear, Nose and Throat
Hazem Mohammed Abdel Tawab, Fadi Mahmoud Gharib, Tareq M Algarf, Louay S ElSharkawy
OBJECTIVE: To compare the outcome and success of repair of uncomplicated tympanic membrane perforations with myringoplasty alone and when combined with mastoidectomy. METHODS: A prospective study where 40 patients with non-cholesteatomatous chronic suppurative otitis media (CSOM) were recruited during the period of June 2013 to December 2013 from the outpatient clinic of Otorhinolaryngology department, Faculty of medicine, Cairo University. Patients were managed medically and after dryness of their perforations they were operated upon...
2014: Clinical Medicine Insights. Ear, Nose and Throat
Mahmoud A Khalil, Hazem M Abdel Tawab
BACKGROUND: Bilateral abductor vocal fold paralysis can lead to respiratory distress and dyspnea. OBJECTIVES: To assess the efficacy of CO2 laser unilateral posterior cordotomy in cases with bilateral abductor paralysis as regards improvement of dyspnea with preservation of satisfactory voice and swallowing after the operation. METHODS: A prospective study was done on 18 patients with bilateral abductor vocal fold paralysis (10 females and 8 males) from November 2010 to December 2012 with their ages ranging from 32 to 64 years...
2014: Clinical Medicine Insights. Ear, Nose and Throat
Katri Aro, Tuomas Klockars, Ilmo Leivo, Antti Mäkitie
BACKGROUND: Salivary gland cancer (SGC) accounts for 3-5% of head and neck malignancies, and register-based studies estimate the familial proportion to be 0.15%. OBJECTIVE: We studied familial predisposition for SGC in the genetically distinct Finnish population. PATIENTS AND METHODS: We sent a patient questionnaire to 161 Finnish SGC patients, 86 of whom responded. RESULTS: A total of 76% of the patients reported having one or more relatives with cancer, 30% two or more, and 9% three or more but only one patient reported having a relative with SGC...
2014: Clinical Medicine Insights. Ear, Nose and Throat
Preetam Chappity, Rakesh Kumar, Ramesh C Deka, Venkatakarthikeyan Chokkalingam, Anoop Saraya, Kapil Sikka
BACKGROUND: Laryngopharyngeal reflux disease can present with a varied symptomatology because of the involvement of multiple sub-sites of the upper aero-digestive tract. It is a very common disease to be encountered in routine practice by both medical and ENT personnel. Its association with multiple pathologies including malignancy warrants an early diagnosis and management. The lack of cost effective and non-invasive tests constitutes a major hurdle in its early management. OBJECTIVES: 1...
2014: Clinical Medicine Insights. Ear, Nose and Throat
Mohammed A Gomaa, Abdel Rahim A Abdel Karim, Hosny S Abdel Ghany, Ahmed A Elhiny, Ahmed A Sadek
BACKGROUND: Acquired cholesteatomas are commonly seen in patients less than 30 years. There is a typical history of recurrent middle ear infections with tympanic membrane perforation. The diagnosis of cholesteatoma is usually made on otologic examination. OBJECTIVE: The aim of the work was to study the role of high resolution computed tomography (HRCT) in detecting, evaluating, and diagnosing middle ear cholesteatoma. PATIENTS AND METHODS: This was a prospective study that included 56 consecutive patients with chronic suppurative otitis media, unsafe type cholesteatomas...
2013: Clinical Medicine Insights. Ear, Nose and Throat
Peter Wong, Caroline Xu, Nahla Gomaa, Allan Ho
OBJECTIVE: To present a case of spontaneous, bilateral hemotympanum secondary to chemotherapy-induced thrombocytopenia. METHODS: Case report and review of the literature. RESULTS: Bilateral spontaneous hemotympanum is an exceedingly rare event. We present the first case of nontraumatic bilateral hemotympanum secondary to chemotherapy-induced thrombocytopenia in a patient with acute myelogenous leukemia. The patient presented with a 7-day history of progressive bilateral hearing loss and a platelet count of 10 × 10(9)/L after receiving his first dose of induction chemotherapy...
2013: Clinical Medicine Insights. Ear, Nose and Throat
Mohammed A Gomaa, Moustafa S Hammad, Abobakr Abdelmoghny, Ashraf M Elsherif, Heba M Tawfik
OBJECTIVE: The study purpose was to detect the value of magnetic resonance imaging (MRI) compared to computed tomography (CT) and different imaging modalities as conventional radiology in evaluation of sinonasal neoplasms diagnosed by Histopathology. METHODS: Thirty patients (16 males and 14 females) were complaining of symptoms related to sinonasal tract. After thorough clinical and local examination, the patients were subjected to the following: conventional radiography, CT, MRI, and histopathological examination...
2013: Clinical Medicine Insights. Ear, Nose and Throat
Hatem Soliman Badran, Khairy M Abulnasr, Sherien Abd El Hameed Nasser
OBJECTIVE: Language is almost always affected in fragile X syndrome (FXS), and a delay in language acquisition is one of the first characteristics. The aim of this work was to study the effect of recurrent middle ear infections on the language profile in boys with FXS. STUDY DESIGN: Prospective case series. SETTING: Academic Medical Center. SUBJECTS AND METHODS: The present study was conducted on 30 males, ranging in age from 4-10 years...
2013: Clinical Medicine Insights. Ear, Nose and Throat
Min Xiong, Huangwen Lai, Chuanhong Yang, Weiyi Huang, Jian Wang, Xiaoyan Fu, Qinglian He
OBJECTIVE: Oxidative damage is a critical role which involves hearing loss induced by impulse noise. That exogenous antioxidant agents reduce noise induced hearing loss (NIHL) has been well demonstrated in both animal studies and clinical practices. Choosing a stronger and more effective antioxidant is very important for treatment of NIHL. Vitamin E, α-lipoic acid, and radix astragali are the most commonly used anti-oxidants for cochlear oxidative damage from acoustic trauma. In this study, the protective effects of radix astragali, α-lipoic acid, and vitamin E on acute acoustic trauma are investigated...
2012: Clinical Medicine Insights. Ear, Nose and Throat
Pyeko Menach, Herbert O Oburra, Asmeeta Patel
Laryngeal squamous cell carcinoma (SCC) is strongly linked to cigarette smoking. It is estimated to account for more than 70% of laryngeal SCCs and up to 89% in combination with alcohol. We wished to determine the prevalence of cigarette smoking and alcohol ingestion among patients with laryngeal squamous cell carcinoma and estimate risk attributed to cigarette smoking and alcohol ingestion. Fifty experimental group patients and fifty controls were recruited of matching age, sex and region of residence. History of smoking and alcohol intake was taken and analyzed to estimate the relative strengths of these exposures...
2012: Clinical Medicine Insights. Ear, Nose and Throat
Akshar N Patel, Janice M Mehnert, Sung Kim
EGFR belongs to the ErbB family of receptor tyrosine kinases and is associated with worse prognosis in head and neck squamous cell carcinoma (HNSCC). Cetuximab is a monoclonal antibody to the extracellular domain of EGFR and inhibits its downstream actions via multiple mechanisms. Besides its proven efficacy in locally advanced and incurable HNSCC, cetuximab has the distinct advantage of having a relatively tolerable side effect profile and not potentiating radiation toxicity. Though therapies for advanced HNSCC are evolving, locoregional recurrence and/or distant metastases occur in a large percentage of patients...
2012: Clinical Medicine Insights. Ear, Nose and Throat
Patorn Piromchai, Surapol Suetrong, Suwanna Arunpongpaisal
BACKGROUND: Rhinoplasty is the most common operation performed by our facial plastic surgery unit. Recognition of patients with psychological problems which may result in an unfavourable post-operative outcome is essential. The objective of this study was to evaluate the psychological status of patients seeking rhinoplasty, compared with the general population. METHODS: We prospectively collected the data from patients who requested rhinoplasty in Srinagarind hospital, Thailand and controls...
2011: Clinical Medicine Insights. Ear, Nose and Throat
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