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Leukemia Research Reports

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https://www.readbyqxmd.com/read/29892554/incident-adverse-events-following-therapy-for-acute-promyelocytic-leukemia
#1
Peter Geon Kim, Kelly Bridgham, Evan C Chen, Mahesh K Vidula, Olga Pozdnyakova, Andrew M Brunner, Amir T Fathi
The use of all-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO) with or without cytotoxic chemotherapy is highly effective in acute promyelocytic leukemia (APL) but incident chronic adverse events (AEs) after initiation of therapy are not well understood. We retrospectively analyzed adult patients with newly diagnosed APL from 2004 through 2014 to identify incident AEs following treatment and contributing risk factors. Cardiac and neurologic AEs were more common and characterized in detail. Cardiac AEs such as the development of coronary artery disease (CAD), arrhythmias, and heart failure had a cumulative incidence of 6...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29892553/acute-myeloid-leukemia-with-t-4-12-q12-p13-treated-with-an-allogeneic-stem-cell-transplant-a-case-report-and-review-of-the-literature
#2
Christie Hancock, Dimitra Kanaloupitis, Ronald Sirota, Jillene Kogan, Leonard Klein, John Eklund
No abstract text is available yet for this article.
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29892552/secondary-clonal-hematologic-neoplasia-following-successful-therapy-for-acute-promyelocytic-leukemia-apl-a-report-of-two-cases-and-review-of-the-literature
#3
Daria Gaut, Joshua Sasine, Gary Schiller
Although rare, secondary clonal hematologic neoplasia may occur after successful therapy for acute promyelocytic leukemia (APL). These secondary clonal events may be considered therapy-related, but may also be due to an underlying background of clonal hematopoiesis from which both malignancies may develop. In this manuscript, we describe two patients with secondary clones after APL therapy characterized in one patient by deletion of chromosome 11q23 and, in the other, by monosomy of chromosome 7, and also provide a review of all secondary clonal disorders described after APL therapy...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29892551/delayed-diagnosis-of-shwachman-diamond-syndrome-with-short-telomeres-and-a-review-of-cases-in-asia
#4
Shin Yeu Ong, Shao-Tzu Li, Gee Chuan Wong, Aloysius Yew Leng Ho, Chandramouli Nagarajan, Joanne Ngeow
Inherited bone marrow failure syndrome (IBMFS) including Shwachman Diamond Syndrome (SDS) can present initially to the hematologist with myelodysplastic syndrome (MDS). Accurate diagnosis affects choice of chemotherapy, donor selection, and transplant conditioning. We report a case of delayed diagnosis of SDS in a family with another child with aplastic anemia, and review reported cases of SDS in Asia. This highlights the gap in identifying inherited bone marrow failure syndromes in adults with hematologic malignancies...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29892550/the-fear-of-lymphadenopathy-a-cautionary-case-of-sarcoidosis-masquerading-as-recurrent-diffuse-large-b-cell-lymphoma-dlbcl
#5
Peter D Whooley, Russell K Dorer, David M Aboulafia
We describe the cautionary case of a patient with advanced-stage large B-cell lymphoma (DLBCL). After combination chemotherapy, CT-PET revealed a persistent focus of likely DLBCL for which he received radiotherapy. Follow-up CT-PET showed diffuse hypermetabolic adenopathy and recurrent DLBCL was presumed. As part of clinical trial assessment, multiple biopsies showed non-caseating lymphadenitis consistent with sarcoidosis. No treatment for asymptomatic sarcoidosis was required and 18 months later he remains cancer-free...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29892549/a-case-of-chronic-eosinophilic-leukemia-with-secondary-transformation-to-acute-myeloid-leukemia
#6
Mattias Hofmans, Anke Delie, Karl Vandepoele, Nadine Van Roy, Joni Van der Meulen, Jan Philippé, Ine Moors
The natural history of primary eosinophilia remains highly variable and is characterized by underlying disease heterogeneity. Chronic eosinophilic leukemia, not otherwise specified (CEL-NOS) is a rare and aggressive disease characterized by non-specific cytogenetic abnormalities or elevated blasts, with high risk of transformation to acute leukemia. We describe a case of CEL-NOS with two hierarchically related non-specific cytogenetic rearrangements, associated with an NPM1 mutation and followed by evolution to secondary AML...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29892548/anti-cd19-chimeric-antigen-receptor-targeting-of-cd19-acute-myeloid-leukemia
#7
Gina Ma, Yi Wang, Tahmeena Ahmed, Ann-Leslie Zaslav, Laura Hogan, Cecilia Avila, Masayuki Wada, Huda Salman
Aberrant expression of CD19 in acute myeloid leukemia (AML) is commonly associated with t(8;21)(q22;q22), although AML cases lacking this translocation occasionally express CD19. Mixed-phenotype acute leukemia also frequently expresses CD19. Chimeric antigen receptor (CAR) technology is a major breakthrough for cancer treatment, with the recent approval of CD19-directed CAR (CD19CAR) for treating B-cell malignancies. However, little information exists on using CD19CAR for other CD19 positive neoplasms such as AML...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29892547/1-25-oh-2-vitamin-d-3-and-akt-inhibition-increase-glucocorticoid-induced-apoptosis-in-a-model-of-t-cell-acute-lymphoblastic-leukemia-all
#8
Maximilian Pistor, Lisa Schrewe, Steffen Haupeltshofer, Andrei Miclea, Simon Faissner, Andrew Chan, Robert Hoepner
In acute lymphoblastic leukemia (ALL), steroid resistance and hypovitaminosis D are both associated with a poor prognosis. We show that methylprednisolone, calcitriol and the AKT-inhibitor MK-2206 have a synergistic effect on the apoptosis of steroid resistant T-ALL cells. Compared to methylprednisolone monotherapy, calcitriol increases methylprednisolone induced apoptosis dose-dependently (1.37-1.92-fold; p < 0.05). Pre-incubation with calcitriol increases the apoptotic effect of MK-2206 even further (3...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29892546/acute-promyelocytic-leukemia-presenting-with-features-of-metastatic-osseous-disease
#9
Carmen Winters, Andy I Chen, Stephen Moore, Elie Traer, Jennifer Dunlap
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia defined by a balanced translocation between chromosomes 15 and 17 resulting in fusion of the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid receptor-alpha gene (RARα) on chromosome 17. APL often presents with pancytopenia and is associated with a life threatening coagulopathy making prompt diagnosis and initiation of therapy critical. We report an unusual case of APL in a 59 year old female without peripheral blood abnormalities or diffuse marrow involvement...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29892545/forskolin-attenuates-doxorubicin-induced-accumulation-of-asymmetric-dimethylarginine-and-s-adenosylhomocysteine-via-methyltransferase-activity-in-leukemic-monocytes
#10
Sandhiya Ramachandran, Swetha Loganathan, Vinnie Cheeran, Soniya Charles, Ganesh Munuswamy-Ramanujan, Mohankumar Ramasamy, Vijay Raj, Kanchana Mala
Doxorubicin (DOX) is an antitumor drug, associated with cardiomyopathy. Strategies to address DOX-cardiomyopathy are scarce. Here, we identify the effect of forskolin (FSK) on DOX-induced-asymmetric-dimethylarginine (ADMA) accumulation in monocytoid cells. DOX-challenge led to i) augmented cytotoxicity, reactive-oxygen-species (ROS) production and methyltransferase-enzyme-activity identified as ADMA and s-adenosylhomocysteine (SAH) accumulation (SAH-A). However, except cytotoxicity, other DOX effects were decreased by metformin and FSK...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29892544/a-rare-case-of-a-minimally-secretory-plasma-cell-leukemia-with-a-hemorrhagic-gastric-plasmacytoma
#11
Akshjot Puri, Michelle W Lau, Xianfeng F Zhao, Keith C Chan, Kimberly Bader
No abstract text is available yet for this article.
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29892543/rituximab-monotherapy-become-an-optimal-treatment-for-primary-pulmonary-malt-lymphoma
#12
A I Alvarez-Sánchez, C Martínez-Losada
No abstract text is available yet for this article.
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29892542/subcutaneous-rituximab-given-to-patients-for-other-indications-than-cd20-b-cell-lymphoma-a-monocentric-study-of-20-cases
#13
Pierre Peterlin, Thierry Guillaume, Alice Garnier, Amandine Le Bourgeois, Beatrice Mahé, Viviane Dubruille, Nicolas Blin, Pierre Gallas, Cyrille Touzeau, Thomas Gastinne, Anne Lok, Patrick Thomare, Cecile Chauvin, Steven Le Gouill, Philippe Moreau, Patrice Chevallier
No abstract text is available yet for this article.
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29761072/sezary-syndrome-manifesting-as-posttransplant-lymphoproliferative-disorder
#14
Thanh-Phuong Afiat, Xiaohui Zhang, Hailing Zhang, Ernesto Ayala, Ling Zhang, Lubomir Sokol
Posttransplant lymphoproliferative disorders (PTLDs) of T-cell orgin are rare biologically heterogeneous diseases of mature lymphoid cells manifesting in immunosuppressed patients. Only a few cases of mycosis fungoides diagnosed post allogeneic hematopoietic cell transplant (alloHSCT) have been described so far. We present a patient with myelodysplastic syndrome (MDS) post matched unrelated donor alloHSCT who was on long-term immunosuppressive therapy due to graft versus host disease. Three years after an alloHSCT, she developed generalized erythroderma and peripheral blood lymphocytosis...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29682446/systemic-lupus-erythematosus-and-myelofibrosis-a-case-report-and-revision-of-literature
#15
F Del Porto, C Tatarelli, A Di Napoli, M Proietta
Blood cytopenia represents one of the diagnostic criteria for systemic lupus erythematosus (SLE) and may occur as the first symptom of the disease. Antibody-mediated peripheral destruction of blood cells is the main cause of cytopenia observed in patients affected by SLE, however, inflammatory anemia, nutritional deficiencies, immunosuppressive therapy and, more rarely, myelofibrosis (MF) have also been documented. In the literature, 45 cases of autoimmune MF (AIMF) and SLE have been previously reported. Here the 46 th case of a 43-year-old female with a SLE and an underhand cytopenia, with a review of the literature...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29556468/unrelated-hla-mismatched-microtransplantation-in-a-patient-with-refractory-secondary-acute-myeloid-leukemia
#16
Nathan Punwani, Noah Merin, Ann Mohrbacher, George Yaghmour, Allison Sano, Laleh Ramezani, Preet M Chaudhary, Giridharan Ramsingh
Microtransplantation (MST), a type of HLA-mismatched allogeneic cellular therapy, is a promising, cellular therapy for acute myeloid leukemia (AML). MST transfuses granulocyte colony-stimulating factor (G-CSF)-mobilized, HLA-mismatched donor peripheral blood stem cells into patients undergoing conventional chemotherapy. MST, using haploidentical donors, has been shown to yield clinical benefit without any permanent marrow engraftment in AML. Consequently, graft-versus-host disease concerns are rendered irrelevant with no need for immunosuppression...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29326868/essential-thrombocytemia-following-immune-thrombocytopenia-with-jak2v617f-mutation
#17
Giovanni Caocci, Sandra Atzeni, Monica Usai, Giorgio La Nasa
JAK2V617F mutation is found in about 60% of cases of essential thrombocytemia (ET) and represents a driving mutation. Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a low platelet (PLT) count. So far, only 2 reports described ET following ITP. For the first time we analyzed in a patient the JAK2V617F allele burden at ITP onset occurred 13 years before the ET diagnosis and found the presence of a small clone JAK2V617F positive clone (3%) raised to 27% in the following years. The association of ET and ITP could suggest similar pathogenetic mechanisms that should be further investigated...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29270355/expression-of-a-specific-extracellular-matrix-signature-is-a-favorable-prognostic-factor-in-acute-myeloid-leukemia
#18
Valerio Izzi, Juho Lakkala, Raman Devarajan, Eeva-Riitta Savolainen, Pirjo Koistinen, Ritva Heljasvaara, Taina Pihlajaniemi
Relapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet been investigated. Here we have investigated whether the expression of a 15-ECM gene signature could be applied to clinical AML research evaluating a retrospective cohort of 61 AML patients and 12 healthy donors. Results show that patients whose ECM signature expression is at least twice as that of healthy donors have considerably longer relapse-free survival, with further stage-specific therapy outcomes...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29264111/alemtuzumab-based-therapy-for-secondary-malignant-histiocytosis-arising-from-pre-b-all
#19
Muhammad Bilal Abid, Karan Wadera, Jenny M Bird, Joya Pawade, David I Marks
•Secondary Malignant Histiocytosis (SMH) is an exceedingly rare, life-threatening condition that invariably occurs in the presence of an underlying monoclonal hematologic disorder. Prognosis of SMH remains dismal and there is no established treatment. •We report a case of a patient who developed SMH during induction chemotherapy for his underlying pre-B-ALL, that caused persistently high fevers and was only diagnosed by a marrow while cytopenic in phase 2 induction. He was treated with alemtuzumab-based therapy that reduced the histiocytic infiltration of the bone marrow from 80% to 15% and made him eligible to undergo T-cell replete allogeneic stem transplantation from his sibling...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29204341/case-report-exome-sequencing-identifies-t-all-with-myeloid-features-as-a-ikzf1-struck-early-precursor-t-cell-malignancy
#20
Marcus C Hansen, Line Nederby, Eigil Kjeldsen, Marianne A Petersen, Hans B Ommen, Peter Hokland
No abstract text is available yet for this article.
2018: Leukemia Research Reports
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