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Journal of Alcoholism and Drug Dependence

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https://www.readbyqxmd.com/read/29038792/neuroanatomical-relationships-between-orexin-hypocretin-containing-neurons-nerve-fibers-and-nicotine-induced-c-fos-activated-cells-of-the-reward-addiction-neurocircuitry
#1
Ozra Dehkordi, Jed E Rose, Martha I Dávila-García, Richard M Millis, Samar Ali Mirzaei, Kebreten F Manaye, Annapurni Jayam-Trouth
Orexin/hypocretin-containing neurons in lateral hypothalamus (LH) are implicated in the neurobiology of nicotine addiction. However, the neuroanatomical relationships between orexin-neurons/nerve fibers and nicotine-activated cells within the reward-addiction neurocircuitry is not known. In the present study in mice, we first used c-Fos immunohistochemistry to identify CNS cells stimulated by an acute single injection of nicotine (NIC, 2 mg/kg, IP). Sequential double-labelling was then performed to identify the location of orexin-containing neurons and nerve fibers with respect to NIC-induced c-Fos activated cells and/or tyrosine hydroxylase (TH) immunoreactive (IR) cells of the mesocorticolimbic reward-addiction pathways...
August 2017: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/29034263/modeling-causal-relationships-among-brain-areas-in-the-mesocorticolimbic-system-during-resting-state-in-cocaine-users-utilizing-a-graph-theoretic-approach
#2
Suchismita Ray, Bharat B Biswal, Ashley Aya, Suril Gohel, Aradhana Srinagesh, Catherine Hanson, Stephen J Hanson
OBJECTIVE: While effective connectivity (EC, causal interaction) between brain areas has been investigated in chronic users of cocaine as they view cocaine pictures cues, no study has examined EC while they take part in a resting-state scan. This resting-state fMRI study aims to investigate the causal interaction among brain areas in the mesocorticolimbic system (MCLS), which is involved in reward and motivation, in cocaine users (vs. controls). METHOD: Twenty cocaine users and 17 healthy controls finished a structural and a resting-state scan...
August 2017: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/29046888/imaging-sex-differences-in-regional-brain-metabolism-during-acute-opioid-withdrawal
#3
Giovanni C Santoro, Joseph Carrion, Stephen L Dewey
The rate of opioid overdose continues to rise, necessitating improved treatment options. Current therapeutic approaches rely on administration of either a blocking agent, such as naloxone, or chronic treatment with replacement drugs, including methadone and/or buprenorphine. Recent findings suggest that males and females respond to these treatments uniquely. In an effort to better understand this sex-specific variation in treatment efficacy, we investigated the effects of acute opioid withdrawal in male and female rats using 18FDG and microPET...
April 2017: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/28845437/examining-brain-networks-in-prescription-opioid-users
#4
Suchismita Ray
No abstract text is available yet for this article.
April 2017: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/28730160/epigenetic-interactions-between-alcohol-and-cannabinergic-effects-focus-on-histone-modification-and-dna-methylation
#5
Tiyash Parira, Alejandra Laverde, Marisela Agudelo
Epigenetic studies have led to a more profound understanding of the mechanisms involved in chronic conditions. In the case of alcohol addiction, according to the National Institute on Alcohol Abuse and Alcoholism, 16 million adults suffer from Alcohol Use Disorders (AUDs). Even though therapeutic interventions like behavioral therapy and medications to prevent relapse are currently available, no robust cure exists, which stems from the lack of understanding the mechanisms of action of alcohol and the lack of development of precision medicine approaches to treat AUDs...
April 2017: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/28868323/fetal-alcohol-exposure-the-common-toll
#6
Marie R Nakhoul, Karl E Seif, Natasha Haddad, Georges E Haddad
Alcohol has always been present in human life, and currently it is estimated that 50% of women of childbearing age consume alcohol. It has become increasingly clear over the last years that alcohol exposure during fetal development can have detrimental effects on various organ systems, and these effects are exerted by alcohol through multiple means, including effects on free radical formation, cellular apoptosis, as well as gene expression. Fetal alcohol exposure can lead to a spectrum of short term as well as long-term problems, with Fetal Alcohol Syndrome being on the more severe end of that spectrum...
February 2017: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/28164142/importance-of-substrate-coupled-proton-antiport-by-the-vesicular-monoamine-transporter-in-the-actions-of-amphetamines-in-drosophila-brain
#7
Takato Hiranita, Zachary Freyberg
No abstract text is available yet for this article.
December 2016: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/28070538/lack-of-effects-of-toll-like-receptor-4-antagonists-on-the-reinforcing-effects-of-cocaine-and-remifentanil
#8
COMMENT
Takato Hiranita
No abstract text is available yet for this article.
December 2016: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/27034967/knowledge-awareness-and-behavior-hiv-aids-and-disasters
#9
Eloise Dunlap
African Americans are the most affected by HIV/AIDS. Both males and females continue to be disproportionately affected by HIV/AIDS. They are often drug users or participate in street/drug subculture. Recent weather disasters have required identification of knowledge, beliefs, conduct norms and behavior patterns that are HIV/AIDS risk factors for disaster survivors. This paper examines patterns of behavior and common practices related to HIV among disaster survivors. STUDY BACKGROUND: Data for this paper come from a three year renewal project which focused upon the processes by which illicit drug markets were reformulated after disasters and practices of risk behaviors for HIV/AIDS...
February 2016: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/27588299/dat-conformation-does-not-predict-the-ability-of-atypical-dopamine-uptake-inhibitors-to-substitute-for-cocaine
#10
Takato Hiranita
No abstract text is available yet for this article.
2016: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/27588298/identification-of-antagonists-selective-for-sigma-receptor-subtypes-that-are-active-in-vivo
#11
Takato Hiranita
No abstract text is available yet for this article.
2016: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/27376101/identification-of-the-sigma-2-receptor-distinct-from-the-progesterone-receptor-membrane-component-1-pgrmc1
#12
Takato Hiranita
No abstract text is available yet for this article.
2016: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/27376100/-trans-%C3%AE-9-tetrahydrocannabinol-like-discriminative-stimulus-effects-of-gabapentin-in-cannabis-users
#13
Takato Hiranita
No abstract text is available yet for this article.
2016: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/27066517/sexual-risk-behavior-among-male-and-female-truant-youths-exploratory-multi-group-latent-class-analysis
#14
Richard Dembo, Jennifer Wareham, Julie Krupa, Ken C Winters
Little is known of sexual risk behaviors among truant youths across gender. This study utilized latent class analysis to examined heterogeneity of sexual risk behaviors across gender among a sample of 300 truant adolescents. Results revealed two latent subgroups within gender: low vs. high sexual risk behaviors. There were gender differences in baseline covariates of sexual risk behaviors, with male truants in higher risk group experiencing ADHD (attention deficit hyperactivity disorder) problems, and female truants in higher risk group experienced marijuana use and depression symptoms...
December 1, 2015: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/26692436/teen-alcohol-use-and-social-networks-the-contributions-of-friend-influence-and-friendship-selection
#15
Jacob E Cheadle, Katrina M Walsemann, Bridget J Goosby
BACKGROUND: We evaluated the contributions of teen alcohol use to the formation and continuation of new and existing friendships while in turn estimating the influence of friend drinking on individuals' regular use and heavy drinking. METHOD: Longitudinal network analysis was used to assess the mutual influences between teen drinking and social networks among adolescents in two large Add Health schools where full network data was collected three times. Friendship processes were disaggregated into the formation of new friendships and the continuation of existing friendships in a joint model isolating friendship selection and friend influences...
October 2015: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/27377120/in-vivo-significance-of-in-vitro-studies-on-g-protein-coupled-receptor-heteromers
#16
Takato Hiranita
No abstract text is available yet for this article.
April 2015: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/26146647/methamphetamine-use-among-homeless-former-foster-youth-the-mediating-role-of-social-networks
#17
Amanda Yoshioka-Maxwell, Eric Rice, Harmony Rhoades, Hailey Winetrobe
OBJECTIVES: Social network analysis can provide added causal insight into otherwise confusing epidemiologic findings in public health research. Although foster care and homelessness are risk factors for methamphetamine use, current research has failed to explicate why homeless youth with foster care experience engage in methamphetamine use at higher rates than other homeless young adults. This study examined the mediating effect of network engagement and time spent homeless on the relationship between foster care experience and recent methamphetamine use among homeless youth in Los Angeles...
April 2015: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/26501067/platelets-contribute-to-bbb-disruption-induced-by-hiv-and-alcohol
#18
Madhavan Nair, Jose Mb Maria, Marisela Agudelo, Adriana Yndart, Mayra E Vargas-Rivera
The role of platelets in the neurological diseases that underlie cognitive impairment has attracted increasing attention in recent years. Multiple pathways in platelets contribute to host defenses, as well as to CNS function. In the current study, we hypothesize that the Blood Brain Barrier (BBB) is disrupted when exposed to platelets from patients with triple Co-morbidity (hazardous alcohol users+ HIV+ thrombocytopenia), compared to those with dual, single or no morbidity (HIV only, alcohol only or healthy controls)...
February 2015: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/26478902/alcohol-versus-cannabinoids-a-review-of-their-opposite-neuro-immunomodulatory-effects-and-future-therapeutic-potentials
#19
Madhavan P Nair, Gloria Figueroa, Gianna Casteleiro, Karla Muñoz, Marisela Agudelo
Due to the legalization of marijuana and the increased demand for cannabis and alcohol consumption, research efforts highlighting the biomedical consequences of the use of alcohol and cannabinoids are not only relevant to the substance abuse scientific field, but are also of public health interest. Moreover, an overview of the recent literature about alcohol and cannabinoids neuro-immunomodulatory effects highlighting their future therapeutic potentials will provide a significant contribution to science and medicine...
February 2015: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/27413771/medications-discovery-importance-of-assessment-of-drug-self-administration-dose-effect-curves
#20
Takato Hiranita
No abstract text is available yet for this article.
2015: Journal of Alcoholism and Drug Dependence
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