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Chinese Clinical Oncology

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https://www.readbyqxmd.com/read/29486570/sweet-syndrome-as-the-leading-symptom-in-the-diagnosis-of-gastric-cancer
#1
Alberto Jacobo Cunquero-Tomás, Jose María Ortiz-Salvador, Vega Iranzo, Carlos Camps
Sweet syndrome is a neutrophilic infiltration of the papillary dermis, which may be associated with the presence of unknown malignancies, either haematological or solid tumours, in 1 out of 5 cases, being considered then as a paraneoplastic syndrome. We present the case of a male with a locally advanced gastric cancer whose final diagnosis was led by the prior debut of Sweet syndrome not explained by other causes.
February 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29486569/-cor-occidere-a-novel-strategy-of-targeting-the-tumor-core-by-radiosurgery-in-a-radio-and-chemo-resistant-intracranial-hemangiopericytoma
#2
You Quan Li, Eu Tiong Chua, Kevin L M Chua, Melvin L K Chua
Intracranial hemangiopericytomas (HPC) are chemotherapy- and radiotherapy (RT)-resistant. Here, we report on a novel stereotactic radiosurgery (SRS) technique-"Cor Occidere" (Latin), as a potential strategy of overcoming radioresistance of HPC. A 36-year old female presented to our clinic for consideration of a 3rd-course of RT for her recurrent cavernous sinus HPC, following previous cranial RT at 13 and 5 years prior, and a failed 9 months trial of bevacizumab/temozolomide. The tumor-adjacent brain stem and carotid artery risked substantial damage given the cumulative RT doses to these organs...
February 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29486568/comprehensive-clinical-genetics-care-for-patients-with-inherited-colorectal-cancer-associated-with-lynch-syndrome-western-and-asian-perspectives
#3
Yun Yang, Y Nancy You
Lynch syndrome (LS) arises from germline mutations that lead to defective functioning of the DNA mismatch repair (MMR) system. It is the most common cause of inherited colorectal cancer (CRC), and predisposes individuals to significantly elevated risks for extracolonic cancers. A sensitive and accurate diagnostic approach will enable proactive management of the proband and at-risk relatives in order to minimize their cancer burden. Comprehensive clinical genetics care should include personalized and tailored multidisciplinary oncologic care, with consideration for the extent of surgical resection, the choice of systemic agents, and the use of radiation...
February 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29486567/role-of-immune-checkpoint-inhibitors-and-novel-immunotherapies-in-uveal-melanoma
#4
Vishal Jindal
Uveal melanoma (UM) is one of the rare malignancies, which can be lethal despite local treatment. Treatment options available now can control UM in early stages, but once it metastasized to distant organs especially liver, prognosis is poor. Immune checkpoint inhibitors (ICIs) are the new revolutionary treatment in management of metastatic cutaneous melanoma. UM and cutaneous melanoma are similar as both of them derived from melanocytes but in terms of mutational load and expression of antigens they are distinct...
February 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29486566/pancreaticoduodenectomy-with-en-bloc-vein-resection-for-locally-advanced-pancreatic-cancer-a-case-series-without-venous-reconstruction
#5
Michele M Gage, Bradley N Reames, Aslam Ejaz, Johnathan Sham, Elliot K Fishman, Matthew J Weiss, Christopher L Wolfgang, Jin He
Resection with clean margin (R0 resection) is associated with better survival in patients with pancreatic cancer. Over the last decade, advancements in preoperative chemotherapy and radiation therapy in pancreatic cancer have led to expansion of indications for surgical resection. Current guidelines define pancreatic cancer with unreconstructable vascular involvement as locally advanced, or surgically unresectable. We present our experience in managing patients with locally advanced pancreatic cancer with a very unique series of patients who achieved R0 resection despite "unresectable" vascular involvement...
February 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29307196/emilia-use-cunning-to-survive-cancer
#6
Joseph Gligorov, Sandrine Richard, Xavier Pivot
No abstract text is available yet for this article.
February 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29307195/choice-of-chemotherapy-regimen-for-early-her2-positive-breast-cancer-in-elderly-patients
#7
Noam Pondé, Evandro de Azambuja
No abstract text is available yet for this article.
February 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29307204/targeting-the-stroma-in-pancreatic-cancer
#8
Daniel H Ahn, Ramesh K Ramanathan
The tumor stroma in pancreatic adenocarcinoma is recognized as an integral component in tumorigenesis through its effects on cell signaling, immunosuppression and inhibitory effect on therapeutic agents. Promising preclinical activity has been observed with novel therapeutic agents that target the tumor microenvironment and represent one of many potential treatment strategies of interest in this disease. Herein, we will highlight and review therapeutic novel agents aimed at tumor stroma in pancreas cancer.
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29307203/interventional-endoscopy-in-the-diagnosis-and-management-of-pancreatic-adenocarcinoma
#9
Asim S Khokhar, Amna F Sher, Mark Schattner
Pancreatic cancer accounts for approximately 3% of all cancers in US, and is the fourth leading cause of mortality in both men and women. It is a silent killer due to lack of early symptoms and the majority of patients present at advanced stage at the time of initial diagnosis. Only 15-20% of patients are candidates for curative resection and even then, the 5-year survival rates range from 10-25%. Despite recent advances in the treatment of advanced pancreatic cancer, the prognosis remains grim with 5-year overall survival (OS) of approximately 10%...
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29307202/imaging-for-pancreatic-ductal-adenocarcinoma
#10
Natally Horvat, Davinia E Ryan, Maria D LaGratta, Pari M Shah, Richard Kinh Do
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide due to its aggressiveness and the challenge to early diagnosis. Complete surgical resection is the only curative option, but fewer than 20% of patients have potentially resectable disease at the time of the diagnosis. Radiologists can assess whether PDAC is resectable, borderline resectable, locally advanced or metastatic based on current imaging tests. This review will outline the role of imaging in both the diagnosis and staging of PDAC, with the goal of assisting the multidisciplinary team in tailoring the best treatment for patients...
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29307201/risk-factors-biomarker-and-imaging-techniques-used-for-pancreatic-cancer-screening
#11
Cyrus Thomas
Pancreatic cancer (PC) is one of the most lethal epithelial malignancies. There have been many attempts aimed at improving survival rates; however, the fatality of PC has been attributed to its few, nonspecific and diverse symptoms that delay diagnosis, rapid metastatic progression and overall treatment resistance. The aggressive nature of PC has stimulated interest in detecting smaller asymptomatic cancers or precursor lesions that are more likely to be curable. This review discusses potential risk factors including lifestyle and genetic variables that are believed to be the most important in contributing to the development of PC...
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29307200/the-diagnosis-and-management-of-cystic-lesions-of-the-pancreas
#12
Peter J Allen
Cystic lesions of the pancreas are radiographic findings that have a very broad histologic differential. This differential spans the spectrum from benign to cancerous, and includes non-neoplastic pseudocysts, benign neoplastic cysts, pre-malignant cysts, and cystic lesions with invasive carcinoma. This chapter will highlight the challenges with diagnosis and management of patients who present with cystic neoplasms of the pancreas.
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29307199/pathologic-classification-of-pancreatic-cancers-current-concepts-and-challenges
#13
Mohamed E Mostafa, Ipek Erbarut-Seven, Burcin Pehlivanoglu, Volkan Adsay
As the most common and most important cancer of the pancreas, with rapid mortality and now also as the third leading cause of cancer-related deaths in the United States, pancreatic ductal adenocarcinoma (PDAC) has become synonymous with "pancreas cancer". PDAC is also the prototype of the "pancreatobiliary-type" adenocarcinomas, along the biliary tract, ampullary and gallbladder cancers with the similar morphology and behavior. Recent molecular profiling studies have identified distinct subsets of PDAC, potentially with different behaviors and targetability...
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29307198/inherited-pancreatic-cancer
#14
Fei Chen, Nicholas J Roberts, Alison P Klein
Pancreatic cancers arise through a series of genetic events both inherited and acquired. Inherited genetic changes, both high penetrance and low penetrance, are an important component of pancreatic cancer risk, and may be used to characterize populations who will benefit from early detection. Furthermore, pancreatic cancer patients with inherited mutations may be particularly sensitive to certain targeted agents, providing an opportunity to personalized treatment. Family history of pancreatic cancer is one of the strongest risk factors for the disease, and is associated with an increased risk of caners at other sites, including but not limited to breast, ovarian and colorectal cancer...
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29307197/preface-for-special-edition-pancreas-cancer
#15
Eileen M O'Reilly, Lei Zheng
No abstract text is available yet for this article.
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29156888/chimeric-antigen-receptor-car-t-and-other-t-cell-strategies-for-pancreas-adenocarcinoma
#16
Anna M Varghese
Treatments in metastatic pancreas cancer remain based in cytotoxic chemotherapy, and novel treatment strategies are needed. Building on the emerging role of T cell therapy in hematologic malignancies and our understanding of the underlying biology of pancreas cancer, research is growing in the role of T cell therapy for patients with solid tumors in general and more specifically patients with pancreas cancer. This review will focus on describing the biology of T cell therapy and its current applications in pancreas cancer...
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29156887/technical-aspects-of-pancreaticoduodenectomy-and-their-outcomes
#17
Katherine Giuliano, Aslam Ejaz, Jin He
Pancreatic cancer is the fourth leading cause of cancer-related death in the Unites States and is rising in incidence. For the 15-25% of patients who do not have either metastatic or locally advanced disease, surgical resection with pancreaticoduodenectomy is the standard of care and results in improved 5-year survival of 15-25%. While mortality at high-volume centers is less than 5%, morbidity remains high at approximately 30-45%. This paper reviews technical aspects of pancreaticoduodenectomy and their outcomes...
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29156886/advocacy-and-pancreas-cancer-a-new-world
#18
Jane Mahoney Holt, Matthew R Alsante
No abstract text is available yet for this article.
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29156891/investigating-the-role-of-tumor-infiltrating-lymphocytes-in-advanced-her2-positive-breast-cancer
#19
EDITORIAL
Stephen J Luen, Sherene Loi
No abstract text is available yet for this article.
November 14, 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29156890/why-the-results-of-adjuvant-pertuzumab-in-her2-positive-early-breast-cancer-has-been-received-as-a-mitigate-success
#20
EDITORIAL
Xavier Pivot, David G Cox, Joseph Gligorov
No abstract text is available yet for this article.
November 9, 2017: Chinese Clinical Oncology
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