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Chinese Clinical Oncology

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https://www.readbyqxmd.com/read/28595424/animal-models-of-meningiomas
#1
Christian Mawrin
Meningiomas are frequent intracranial and intraspinal tumors. They are tumors of the elderly, and meningioma growth at certain localizations, as well as recurrent tumors or primary aggressive biology may pose a therapeutic challenge. To understand the growth characteristics of meningiomas, animal models can provide insights both from a biological and therapeutical point of view. Using genetically-engineered mouse models (GEMM), it has been proven that alterations of the neurofibromatosis type 2 (NF2) gene are key steps for benign meningioma development...
June 4, 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28595423/classification-of-meningiomas-advances-and-controversies
#2
Patrick N Harter, Yannick Braun, Karl H Plate
Meningiomas are the most frequent primary central nervous system (CNS) tumors. Although approximately 80% of the tumors are slow growing and benign, some subtypes are associated with a less favorable outcome. An adequate classification system aims at providing a tool for estimating recurrence and overall survival of meningioma patients. The 2016 version of the World Health Organization (WHO) classification for CNS tumors constitutes a hallmark for neuropathological tumor classification since genetic alterations and histopathology are combined for a final diagnosis...
June 4, 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28482675/a-novel-diagnostic-biomarker-for-human-uterine-leiomyosarcoma-psmb9-%C3%AE-1i
#3
Takuma Hayashi, Miki Kawano, Kenji Sano, Tomoyuki Ichimura, Gal Gur, Pnina Yaish, Dorit Zharhary, Yae Kanai, Susumu Tonegawa, Tanri Shiozawa, Nobuo Yaegashi, Ikuo Konishi
No abstract text is available yet for this article.
April 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28482674/management-of-hepatocellular-in-the-united-states
#4
Ali A Mokdad, Caitlin A Hester, Amit G Singal, Adam C Yopp
Hepatocellular carcinoma (HCC) is a major cause of cancer burden globally. In the United States, the incidence of HCC is forecast to continue to rise for the next 15 years. Patients with HCC vary markedly owing to heterogeneous tumor characteristics and concomitant liver dysfunction. In the United States and Europe, HCC is staged and managed according to the Barcelona Clinic Liver Cancer (BCLC) system. For very early and early stage HCC, or BCLC 0/A, liver transplant is the optimal treatment option. Liver resection and radiofrequency or microwave ablation are alternative treatment options...
April 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28482673/immunotherapy-of-patients-with-metastatic-melanoma
#5
Zhe Yu, Lu Si
Malignant melanoma (MM) is the primary cause of skin cancer related death and the incidence is increasing in the past years. Advanced MM still has a poor prognosis, but in recent years, the development of immunotherapy has changed its poor prognosis. Immune checkpoints show the revolutionary treatment of metastatic melanoma. Ipilimumab and pembrolizumab, monoclonal antibodies against the CTLA-4 and PD-1 respectively, have been shown to prolong overall survival (OS) in patients with advanced melanoma. The combination immunotherapy seems to be superior to monotherapy...
April 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28482672/next-generation-approaches-for-tumor-vaccination
#6
Anand Patel, Howard L Kaufman, Mary L Disis
Tumor vaccines have been an attractive concept in the immunotherapy of cancer based on the central role of tumor-associated antigens in allowing the immune system to recognize cancer cells and the large variety of platforms in which to present such antigens to the immune system. Early clinical studies of vaccines, however, were largely disappointing. Recent evidence that cancer-mediated T cell suppression may prevent T cell activation is leading to renewed interest in vaccine development. The use of T cell checkpoint inhibitors alone has revolutionized the contemporary treatment of human cancer, and has suggested that the emergence of neoantigens may be an important biomarker of therapeutic response...
April 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28482671/advances-in-evidence-based-cancer-adoptive-cell-therapy
#7
Chunlei Ge, Ruilei Li, Xin Song, Shukui Qin
Adoptive cell therapy (ACT) has been developed in cancer treatment by transferring/infusing immune cells into cancer patients, which are able to recognize, target, and destroy tumor cells. Recently, sipuleucel-T and genetically-modified T cells expressing chimeric antigen receptors (CAR) show a great potential to control metastatic castration-resistant prostate cancer and hematologic malignancies in clinic. This review summarized some of the major evidence-based ACT and the challenges to improve cell quality and reduce the side effects in the field...
April 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28482670/immune-checkpoint-inhibitors-in-lung-cancer-current-status-and-future-directions
#8
Yun Fan, Weimin Mao
Recently, the immune checkpoint inhibitors that target programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) have made a breakthrough in treating advanced non-small cell lung cancer (NSCLC) with the efficacy of approximately 20%; among which, nivolumab has acquired treatment indications in lung squamous cell carcinoma. The inhibitors targeting cytotoxic T lymphocyte associated antigen 4 (CTLA-4) are also undergoing clinical trials. Researches on immune checkpoint inhibitors have been rapidly implemented in a variety of different types of lung cancer, such as small cell lung cancer (SCLC) and locally advanced NSCLC, and these inhibitors began to be applied in combination with some established treatments, including chemotherapy, targeting therapy and radiotherapy...
April 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28482669/evaluation-of-mir-22-and-mir-20a-as-diagnostic-biomarkers-for-gastric-cancer
#9
Zahra Jafarzadeh-Samani, Sareh Sohrabi, Khadije Shirmohammadi, Hosein Effatpanah, Reza Yadegarazari, Massoud Saidijam
BACKGROUND: Gastric cancer (GC) is the fourth most common cancers and the second reason for cancer-related death around the world, particularly in East Asian countries. Diagnosing GC in its early stages is followed by more successful treatment. Unfortunately, there is no accurate method for GC diagnosis in its early stages. Recently, miRNAs have been investigated in the most cancer researches which have demonstrated that they have been dysregulated in many cancers. METHODS: This case-control study aims to investigate the expression rate of miR-22 and miR-20a in 32 cancerous tissues as well as 32 healthy adjacent tissues...
April 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28482668/multigene-testing-for-breast-cancer-risk-assessment-an-illusion-of-added-clinical-value
#10
Anna Sokolenko, Evgeny Imyanitov
No abstract text is available yet for this article.
April 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28482667/granisetron-transdermal-delivery-system-is-effective-in-the-control-of-chemotherapy-induced-nausea-and-vomiting-in-patients-receiving-moderately-emetogenic-chemotherapy-mec-or-highly-emetogenic-chemotherapy-hec-in-china
#11
https://www.readbyqxmd.com/read/28285540/professor-norman-wolmark-perseverance-sometimes-pays-off
#12
He Chao-Xiu Melanie
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28285539/commentary-on-lncrna-nbr2-engages-a-metabolic-checkpoint-by-regulating-ampk-under-energy-stress
#13
Sara Malih, Massoud Saidijam
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28285538/the-prospective-of-laparoscopic-pancreaticoduodenectomy-for-cancer-management
#14
REVIEW
Hendi Maher, Weiwei Jin, Yiping Mou, Henry Davies
Laparoscopic pancreaticoduodenectomy (LPD) is an extremely challenging surgery. First described in 1994, LPD has been gaining a favorable position in the majority of pancreatic surgery. Now, LPD is worldwide accepted. A literature search was conducted in PubMed, and only papers written in English containing more than 26 publications of LPD were selected. Papers in distal and robotic pancreatic procedure were not included in the review of a total of 222 LPD publications. The total number of patients analyzed was 1,082 from 25 articles and the largest series...
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28285537/milestone-clinical-trials-of-the-national-surgical-adjuvant-breast-and-bowel-project-nsabp
#15
REVIEW
Priya Rastogi, D Lawrence Wickerham, Charles E Geyer, Eleftherios P Mamounas, Thomas B Julian, Norman Wolmark
The National Surgical Adjuvant Breast and Bowel Project (NSABP) has made significant contributions in reducing the extent of breast surgery and in improving outcomes of patients with early-stage breast cancer through the conduct of large randomized clinical trials evaluating local and systemic therapy. In 2014, the NSABP merged with two other US National Cancer Institute-funded cooperative groups, the Radiation Therapy Oncology Group (RTOG) and the Gynecologic Oncology Group (GOG), to form NRG Oncology. The combined organization has 218 member institutions with more than 600 affiliate centers located throughout the United States, Canada, Puerto Rico, and other international sites...
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28285536/comparison-of-short-term-outcomes-between-laparoscopic-assisted-and-open-complete-mesocolic-excision-cme-for-the-treatment-of-transverse-colon-cancer
#16
COMPARATIVE STUDY
Yong Wang, Chuan Zhang, Yi-Fei Feng, Zan Fu, Yue-Ming Sun
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer worldwide. Although laparoscopic-assisted complete mesocolic excision (LCME) is a superior treatment, there are few studies available on it owe to the low incidence and technical difficulty of LCME in transverse colon cancer. METHODS: The clinical data of 78 patients with transverse colon cancer who were treated by LCME and open complete mesocolic excision (OCME) were retrospectively analyzed. A total of 39 cases had been treated by LCME, compared with 39 cases treated by OCME...
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28285535/improving-clinical-outcomes-with-pembrolizumab-in-patients-with-advanced-melanoma
#17
Dae Won Kim, Jonathan S Zager, Zeynep Eroglu
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28249540/pancreaticoduodenectomy-for-pancreatic-cancer-perspective-from-the-united-states
#18
Aslam Ejaz, Jin He
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28249539/the-promise-of-using-histone-deacetylase-inhibitors-in-combination-treatment-against-breast-cancer-and-other-solid-tumors
#19
Nirmal Perera, Alexander Hergovich
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28249538/parp-inhibitor-and-platinum-agent-in-triple-negative-breast-cancer-utilizing-innovative-trial-design-to-bring-together-something-new-and-something-old
#20
Priyanka Sharma
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
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