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Chinese Clinical Oncology

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https://www.readbyqxmd.com/read/28061546/professor-i-craig-henderson-triple-negative-breast-cancer-is-most-chemo-sensitive-of-all-subtypes-of-cancer
#1
Lucille L Ye
No abstract text is available yet for this article.
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061545/professor-charles-m-balch-higher-sophistication-and-accuracy-of-clean-data-are-important-for-sophisticated-clinical-trials
#2
Chao-Xiu He
No abstract text is available yet for this article.
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061544/findings-from-the-adjuvant-colon-cancer-end-points-accent-collaborative-group-the-power-of-pooled-individual-patient-data-from-multiple-clinical-trials
#3
Lindsay A Renfro, Daniel J Sargent
The Adjuvant Colon Cancer End Points (ACCENT) Collaborative Group was formed 15 years ago to address scientific questions in early stage colon cancer that could best be answered by pooling individual patient data across many randomized clinical trials. Today, the ACCENT database contains detailed information collected from over 40,000 patients enrolled onto 27 major adjuvant colon cancer trials conducted between 1977 and 2009. Since its inception, the ACCENT group has led many sophisticated analyses addressing a variety of clinical questions, such as the long-term survivorship of colon cancer patients by treatment, the time course of oxaliplatin benefit, and support for the use of disease-free survival (DFS) as a surrogate endpoint for overall survival (OS), among many others...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061543/transdermal-granisetron-for-the-prevention-of-nausea-and-vomiting-following-moderately-or-highly-emetogenic-chemotherapy-in-chinese-patients-a-randomized-double-blind-phase-iii-study
#4
Liu-Qing Yang, Xin-Chen Sun, Shu-Kui Qin, Ying-Xia Chen, He-Long Zhang, Ying Cheng, Zhen-Dong Chen, Jian-Hua Shi, Qiong Wu, Yu-Xian Bai, Bao-Hui Han, Wei Liu, Xue-Nong Ouyang, Ji-Wei Liu, Zhi-Hui Zhang, Yong-Qiang Li, Jian-Ming Xu, Shi-Ying Yu
BACKGROUND: The granisetron transdermal delivery system (GTDS) has been demonstrated effectiveness in the control of chemotherapy-induced nausea and vomiting (CINV) in previous studies. This is the first phase III study to evaluate the efficacy and tolerability of GTDS in patients receiving moderately emetogenic chemotherapy (MEC) or highly emetogenic chemotherapy (HEC) in China. METHODS: A total of 313 patients were randomized into the GTDS group (one transdermal granisetron patch, 7 days) or the oral granisetron group (granisetron oral 2 mg/day, ≥2 days)...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061542/an-efficient-method-for-native-protein-purification-in-the-selected-range-from-prostate-cancer-tissue-digests
#5
Rumana Ahmad, Carrie D Nicora, Anil K Shukla, Richard D Smith, Wei-Jun Qian, Alvin Y Liu
BACKGROUND: Prostate cancer (CP) cells differ from their normal counterpart in gene expression. Genes encoding secreted or extracellular proteins with increased expression in CP may serve as potential biomarkers. For their detection and quantification, assays based on monoclonal antibodies are best suited for development in the clinical setting. One approach to obtain antibodies is to use recombinant proteins as immunogen. However, the synthesis of recombinant protein for each identified candidate is time-consuming and expensive...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061541/a-prospective-multicenter-phase-ii-trial-of-low-dose-erlotinib-as-maintenance-treatment-after-platinum-doublet-chemotherapy-for-advanced-non-small-cell-lung-cancer-harboring-egfr-mutation
#6
Satoshi Hirano, Go Naka, Yuichiro Takeda, Motoyasu Iikura, Noriko Hayama, Asako Yanagisawa, Hiroyuki Amano, Makoto Nakamura, Sukeyuki Nakamura, Hiroshi Tabeta, Haruhito Sugiyama
BACKGROUND: Maintenance therapy with full-dose erlotinib for patients with advanced non-small cell lung cancer (NSCLC) has demonstrated a significant overall survival (OS) benefit. However, 150 mg/day of erlotinib seems too toxic as maintenance therapy. This study aimed to evaluate the efficacy and safety of low-dose erlotinib (25 mg/day) as maintenance treatment after platinum doublet chemotherapy in NSCLC harboring epidermal growth factor receptor (EGFR) mutation. METHODS: Activated EGFR-mutation-positive NSCLC patients who did not progress after first-line platinum-doublet chemotherapy, ≥20 and ≤85 years old, with performance status (PS) 0-3 were included in this study...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061540/metallothionein-2a-an-interactive-protein-linking-phosphorylated-fadd-to-nf-%C3%AE%C2%BAb-pathway-leads-to-colorectal-cancer-formation
#7
Faiz M M T Marikar, Guanghui Jin, Wang Sheng, Dingyuan Ma, Zichun Hua
BACKGROUND: The rapid increase in the incidence rate of colorectal cancer has led to the search and identification of biomarkers that can predict risk for and future behavior of this malignancy and management. To study the biological role of the phosphorylated Fas associated death domain (pFADD) gene in colorectal cancer, we performed a GAL4-based yeast two-hybrid screening of a human heart cDNA library. METHODS: A series of two yeast hybrid method was used to identification of protein-protein interaction...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27701872/does-hepatitis-b-virus-infection-cause-breast-cancer
#8
Vishnu Prasad Adhikari, Lin-Jie Lu, Ling-Quan Kong
Lifestyle and family history are two of the most important risk factors for breast cancer (BC). However, these risk factors cannot explain the differences in the incidence and early BC onset among Chinese females compared to their western counterparts. We propose in this hypothesis the potential mechanism of indirect oncogenesis of hepatitis B virus (HBV) in causing BC through its persistence as occult infection and continuous replication with long term subtle liver damage. Estrogen is mainly deactivated in the liver and long term necro-inflammatory damage to liver may result in persistent high level of estrogen, which is a dominant risk factor for BC...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27701871/resistance-patterns-to-anti-pd-1-therapy-in-metastatic-melanoma
#9
Alpaslan Ozgun, Vernon K Sondak, Joseph Markowitz
No abstract text is available yet for this article.
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27506806/molecular-features-of-response-to-anti-pd-1-therapy
#10
Dirk Schadendorf, Bastian Schilling
No abstract text is available yet for this article.
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27334463/that-s-how-you-make-drugs
#11
Peter Kapitein
Although the science is able to proof that a drug works for the BRCA mutation in breast cancer, prostate cancer and pancreatic cancer (and maybe in other BRCA-mutated cancers) we stick to the registration path of doing phase 1, 2 and 3 trials based on organs. With the knowledge of today and the practice of personalized medicine we are able to give the drug olaparib much faster and save lives or at least extend lives with a good quality of life. This can be done differently if patients are involved in the process of determining the research, designing the trials and organizing the trials...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27334461/setdb1-is-a-new-promising-target-in-hcc-therapy
#12
Carla Cicchini, Cecilia Battistelli, Marco Tripodi
No abstract text is available yet for this article.
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27164857/dysregulation-of-the-epigenetic-regulator-setdb1-in-liver-carcinogenesis-more-than-one-way-to-skin-a-cat
#13
Thomas Longerich
Hepatocellular carcinoma (HCC) is one of the most prevalent human cancers worldwide. Its development is considered a step-wise process in which genetic and epigenetic alterations lead to the activation of oncogenes and the inactivation of tumor suppressor genes. In contrast to genetic alterations, epigenetic changes that include aberrant methylation, histone modification and RNA interference do not alter the genetic code, but affect the level of mRNA transcripts. In addition, these epigenetic alterations may influence each other...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061528/an-icgc-major-achievement-in-breast-cancer-a-comprehensive-catalog-of-mutations-and-mutational-signatures
#14
EDITORIAL
François Bertucci, Max Chaffanet, Daniel Birnbaum
No abstract text is available yet for this article.
November 9, 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27829284/professor-charles-e-geyer-neoadjuvant-therapy-is-becoming-standard-of-care-for-her2-breast-cancer
#15
Lucille L Ye
No abstract text is available yet for this article.
October 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27829283/professor-william-j-gradishar-individualized-treatment-scheme-for-breast-cancer
#16
Celine Lin
No abstract text is available yet for this article.
October 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27829282/dan-sargent-cco-associate-editor-and-mayo-biostatistician-and-clinical-trialist-dies-unexpectedly-at-46
#17
Helen Seliman
No abstract text is available yet for this article.
October 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27829281/percutaneous-biliary-interventions-and-complications-in-malignant-bile-duct-obstruction
#18
Hooman Yarmohammadi, Anne M Covey
Malignant bile duct obstruction can be a challenging clinical problem for patients and physicians alike. Indications for intervention include pruritus, cholangitis, lowering bilirubin pre-operatively or to allow for administration of some chemotherapeutic agents, and to divert bile from a post-operative leak. Low biliary obstruction, obstruction below the common hepatic duct, is usually straightforward and is often treated endoscopically. High bile duct obstruction is more complicated because it often involves isolation of ductal segments...
October 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27829280/gallbladder-cancer-south-american-experience
#19
Gerardo F Arroyo, Alberto Gentile, Luis A Parada
Large differences in terms of incidence and mortality due to gallbladder cancer (GBC) have been reported worldwide. Moreover, it seems that GBC has unique characteristics in South America. We surveyed the literature looking for information about the epidemiology, basic and translational research, and clinical trials performed in South America in order to critically analyze the magnitude of this health problem in the region. Compared to other geographic areas, age-standardized mortality rates (ASMR) for GBC in women are very high, particularly in many western areas of South America...
October 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27829279/combined-intrahepatic-cholangiocarcinoma-and-hepatocellular-carcinoma
#20
Louise C Connell, James J Harding, Jinru Shia, Ghassan K Abou-Alfa
Hepatocellular carcinoma (HCC), the fifth most common cancer globally and third leading cause of cancer-related mortality is a heterogeneous disease with a highly variable clinical course. The inherent biological diversity of hepatic carcinomas may hinder therapeutic decision making and prognostication for patients. One distinct, albeit rare, subtype of primary hepatic carcinoma is combined intrahepatic cholangiocarcinoma and hepatocellular carcinoma (cHCC-ICC), which carries an overall worse prognosis than either HCC or intrahepatic cholangiocarcinoma (ICC) alone...
October 2016: Chinese Clinical Oncology
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