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Chinese Clinical Oncology

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https://www.readbyqxmd.com/read/28285540/professor-norman-wolmark-perseverance-sometimes-pays-off
#1
He Chao-Xiu Melanie
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28285539/commentary-on-lncrna-nbr2-engages-a-metabolic-checkpoint-by-regulating-ampk-under-energy-stress
#2
Sara Malih, Massoud Saidijam
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28285538/the-prospective-of-laparoscopic-pancreaticoduodenectomy-for-cancer-management
#3
REVIEW
Hendi Maher, Weiwei Jin, Yiping Mou, Henry Davies
Laparoscopic pancreaticoduodenectomy (LPD) is an extremely challenging surgery. First described in 1994, LPD has been gaining a favorable position in the majority of pancreatic surgery. Now, LPD is worldwide accepted. A literature search was conducted in PubMed, and only papers written in English containing more than 26 publications of LPD were selected. Papers in distal and robotic pancreatic procedure were not included in the review of a total of 222 LPD publications. The total number of patients analyzed was 1,082 from 25 articles and the largest series...
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28285537/milestone-clinical-trials-of-the-national-surgical-adjuvant-breast-and-bowel-project-nsabp
#4
REVIEW
Priya Rastogi, D Lawrence Wickerham, Charles E Geyer, Eleftherios P Mamounas, Thomas B Julian, Norman Wolmark
The National Surgical Adjuvant Breast and Bowel Project (NSABP) has made significant contributions in reducing the extent of breast surgery and in improving outcomes of patients with early-stage breast cancer through the conduct of large randomized clinical trials evaluating local and systemic therapy. In 2014, the NSABP merged with two other US National Cancer Institute-funded cooperative groups, the Radiation Therapy Oncology Group (RTOG) and the Gynecologic Oncology Group (GOG), to form NRG Oncology. The combined organization has 218 member institutions with more than 600 affiliate centers located throughout the United States, Canada, Puerto Rico, and other international sites...
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28285536/comparison-of-short-term-outcomes-between-laparoscopic-assisted-and-open-complete-mesocolic-excision-cme-for-the-treatment-of-transverse-colon-cancer
#5
COMPARATIVE STUDY
Yong Wang, Chuan Zhang, Yi-Fei Feng, Zan Fu, Yue-Ming Sun
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer worldwide. Although laparoscopic-assisted complete mesocolic excision (LCME) is a superior treatment, there are few studies available on it owe to the low incidence and technical difficulty of LCME in transverse colon cancer. METHODS: The clinical data of 78 patients with transverse colon cancer who were treated by LCME and open complete mesocolic excision (OCME) were retrospectively analyzed. A total of 39 cases had been treated by LCME, compared with 39 cases treated by OCME...
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28285535/improving-clinical-outcomes-with-pembrolizumab-in-patients-with-advanced-melanoma
#6
Dae Won Kim, Jonathan S Zager, Zeynep Eroglu
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28249540/pancreaticoduodenectomy-for-pancreatic-cancer-perspective-from-the-united-states
#7
Aslam Ejaz, Jin He
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28249539/the-promise-of-using-histone-deacetylase-inhibitors-in-combination-treatment-against-breast-cancer-and-other-solid-tumors
#8
Nirmal Perera, Alexander Hergovich
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28249538/parp-inhibitor-and-platinum-agent-in-triple-negative-breast-cancer-utilizing-innovative-trial-design-to-bring-together-something-new-and-something-old
#9
Priyanka Sharma
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061528/an-icgc-major-achievement-in-breast-cancer-a-comprehensive-catalog-of-mutations-and-mutational-signatures
#10
François Bertucci, Max Chaffanet, Daniel Birnbaum
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27506807/chromodomain-helicase-dna-binding-protein-4-a-novel-therapeutic-target-in-liver-cancer-stem-cells
#11
Kouki Nio, Taro Yamashita, Shuichi Kaneko
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27334462/beginnings-of-a-gene-cloud-definition-in-hepatocellular-carcinoma
#12
Christopher Taylor Barry
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27334459/future-prospect-of-gallbladder-therapy-using-hedgehog-signaling-inhibitor
#13
Hideya Onishi
No abstract text is available yet for this article.
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061546/professor-i-craig-henderson-triple-negative-breast-cancer-is-most-chemo-sensitive-of-all-subtypes-of-cancer
#14
Lucille L Ye
No abstract text is available yet for this article.
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061545/professor-charles-m-balch-higher-sophistication-and-accuracy-of-clean-data-are-important-for-sophisticated-clinical-trials
#15
Chao-Xiu He
No abstract text is available yet for this article.
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061544/findings-from-the-adjuvant-colon-cancer-end-points-accent-collaborative-group-the-power-of-pooled-individual-patient-data-from-multiple-clinical-trials
#16
REVIEW
Lindsay A Renfro, Daniel J Sargent
The Adjuvant Colon Cancer End Points (ACCENT) Collaborative Group was formed 15 years ago to address scientific questions in early stage colon cancer that could best be answered by pooling individual patient data across many randomized clinical trials. Today, the ACCENT database contains detailed information collected from over 40,000 patients enrolled onto 27 major adjuvant colon cancer trials conducted between 1977 and 2009. Since its inception, the ACCENT group has led many sophisticated analyses addressing a variety of clinical questions, such as the long-term survivorship of colon cancer patients by treatment, the time course of oxaliplatin benefit, and support for the use of disease-free survival (DFS) as a surrogate endpoint for overall survival (OS), among many others...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061543/transdermal-granisetron-for-the-prevention-of-nausea-and-vomiting-following-moderately-or-highly-emetogenic-chemotherapy-in-chinese-patients-a-randomized-double-blind-phase-iii-study
#17
RANDOMIZED CONTROLLED TRIAL
Liu-Qing Yang, Xin-Chen Sun, Shu-Kui Qin, Ying-Xia Chen, He-Long Zhang, Ying Cheng, Zhen-Dong Chen, Jian-Hua Shi, Qiong Wu, Yu-Xian Bai, Bao-Hui Han, Wei Liu, Xue-Nong Ouyang, Ji-Wei Liu, Zhi-Hui Zhang, Yong-Qiang Li, Jian-Ming Xu, Shi-Ying Yu
BACKGROUND: The granisetron transdermal delivery system (GTDS) has been demonstrated effectiveness in the control of chemotherapy-induced nausea and vomiting (CINV) in previous studies. This is the first phase III study to evaluate the efficacy and tolerability of GTDS in patients receiving moderately emetogenic chemotherapy (MEC) or highly emetogenic chemotherapy (HEC) in China. METHODS: A total of 313 patients were randomized into the GTDS group (one transdermal granisetron patch, 7 days) or the oral granisetron group (granisetron oral 2 mg/day, ≥2 days)...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061542/an-efficient-method-for-native-protein-purification-in-the-selected-range-from-prostate-cancer-tissue-digests
#18
Rumana Ahmad, Carrie D Nicora, Anil K Shukla, Richard D Smith, Wei-Jun Qian, Alvin Y Liu
BACKGROUND: Prostate cancer (CP) cells differ from their normal counterpart in gene expression. Genes encoding secreted or extracellular proteins with increased expression in CP may serve as potential biomarkers. For their detection and quantification, assays based on monoclonal antibodies are best suited for development in the clinical setting. One approach to obtain antibodies is to use recombinant proteins as immunogen. However, the synthesis of recombinant protein for each identified candidate is time-consuming and expensive...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061541/a-prospective-multicenter-phase-ii-trial-of-low-dose-erlotinib-as-maintenance-treatment-after-platinum-doublet-chemotherapy-for-advanced-non-small-cell-lung-cancer-harboring-egfr-mutation
#19
MULTICENTER STUDY
Satoshi Hirano, Go Naka, Yuichiro Takeda, Motoyasu Iikura, Noriko Hayama, Asako Yanagisawa, Hiroyuki Amano, Makoto Nakamura, Sukeyuki Nakamura, Hiroshi Tabeta, Haruhito Sugiyama
BACKGROUND: Maintenance therapy with full-dose erlotinib for patients with advanced non-small cell lung cancer (NSCLC) has demonstrated a significant overall survival (OS) benefit. However, 150 mg/day of erlotinib seems too toxic as maintenance therapy. This study aimed to evaluate the efficacy and safety of low-dose erlotinib (25 mg/day) as maintenance treatment after platinum doublet chemotherapy in NSCLC harboring epidermal growth factor receptor (EGFR) mutation. METHODS: Activated EGFR-mutation-positive NSCLC patients who did not progress after first-line platinum-doublet chemotherapy, ≥20 and ≤85 years old, with performance status (PS) 0-3 were included in this study...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061540/metallothionein-2a-an-interactive-protein-linking-phosphorylated-fadd-to-nf-%C3%AE%C2%BAb-pathway-leads-to-colorectal-cancer-formation
#20
Faiz M M T Marikar, Guanghui Jin, Wang Sheng, Dingyuan Ma, Zichun Hua
BACKGROUND: The rapid increase in the incidence rate of colorectal cancer has led to the search and identification of biomarkers that can predict risk for and future behavior of this malignancy and management. To study the biological role of the phosphorylated Fas associated death domain (pFADD) gene in colorectal cancer, we performed a GAL4-based yeast two-hybrid screening of a human heart cDNA library. METHODS: A series of two yeast hybrid method was used to identification of protein-protein interaction...
December 2016: Chinese Clinical Oncology
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