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World Journal of Transplantation

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https://www.readbyqxmd.com/read/27683639/evaluating-twenty-years-of-follow-up-after-orthotopic-liver-transplantation-best-practice-for-donor-recipient-matching-what-can-we-learn-from-the-past-era
#1
Niklas Buescher, Daniel Seehofer, Michael Helbig, Andreas Andreou, Marcus Bahra, Andreas Pascher, Johann Pratschke, Wenzel Schoening
AIM: To characterize major determinants of 20-year survival after liver transplantation (LT). METHODS: This longitudinal single-institution study includes 313 consecutive patients who received a LT between 1988 and 1992. Pretransplant clinical characteristics and laboratory values were assessed and compared between 20-year survivors and non-survivors. Particular attention was paid to the Model for End-Stage Liver Disease (labMELD)-score and the Eurotransplant Donor Risk Index (ET-DRI) to unravel their impact on 20-year survival after LT...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27683638/underutilization-of-palliative-care-services-in-the-liver-transplant-population
#2
Priya Kathpalia, Alexander Smith, Jennifer C Lai
AIM: To evaluate use of palliative care services in patients with end-stage liver disease who do not have access to liver transplant. METHODS: Evaluated were end-stage liver disease patients who were removed from the liver transplant wait-list or died prior to transplant at a single transplant center over a 2-year period. Those who were removed due to noncompliance or ultimately transplanted elsewhere were excluded from this study. Patient characteristics associated with palliative care consultation were assessed using logistic regression analysis...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27683637/thromboelastographic-reference-ranges-for-a-cirrhotic-patient-population-undergoing-liver-transplantation
#3
Lesley De Pietri, Marcello Bianchini, Gianluca Rompianesi, Elisabetta Bertellini, Bruno Begliomini
AIM: To describe the thromboelastography (TEG) "reference" values within a population of liver transplant (LT) candidates that underline the differences from healthy patients. METHODS: Between 2000 and 2013, 261 liver transplant patients with a model for end-stage liver disease (MELD) score between 15 and 40 were studied. In particular the adult patients (aged 18-70 years) underwent to a first LT with a MELD score between 15 and 40 were included, while all patients with acute liver failure, congenital bleeding disorders, and anticoagulant and/or antiplatelet drug use were excluded...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27683636/pharmacological-tie2-activation-in-kidney-transplantation
#4
Kristina Thamm, Florence Njau, Paul Van Slyke, Daniel J Dumont, Joon-Keun Park, Hermann Haller, Sascha David
AIM: To investigate the therapeutic potential of vasculotide (VT) - a Tie2 activating therapeutic - in kidney transplantation. METHODS: We performed a murine MHC-mismatched renal transplant model (C57Bl/6 male into Balb/c female) with 60 min cold and 30 min warm ischemia time. 500 ng VT was administered i.p. to donor mice 1 h before organ removal. In addition, recipients received 500 ng VT i.p. directly and 3 d after surgery. Survival was monitored and remaining animals were sacrificed 28 d after transplantation...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27683635/updates-on-antibody-mediated-rejection-in-intestinal-transplantation
#5
REVIEW
Guo-Sheng Wu
Antibody-mediated rejection (ABMR) has increasingly emerged as an important cause of allograft loss after intestinal transplantation (ITx). Compelling evidence indicates that donor-specific antibodies can mediate and promote acute and chronic rejection after ITx. However, diagnostic criteria for ABMR after ITx have not been established yet and the mechanisms of antibody-mediated graft injury are not well-known. Effective approaches to prevent and treat ABMR are required to improve long-term outcomes of intestine recipients...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27683634/tregs-and-kidney-from-diabetic-nephropathy-to-renal-transplantation
#6
REVIEW
Periklis Dousdampanis, Kostantina Trigka, Athanasia Mouzaki
Kidney transplantation is recognised as the most effective treatment for patients with end-stage renal disease (ESRD). Kidney transplantation continues to face several challenges including long-term graft and patient survival, and the side effects of immunosuppressive therapy. The tendency in kidney transplantation is to avoid the side effects of immunosuppresants and induce immune tolerance. Regulatory T-cells (Tregs) contribute to self-tolerance, tolerance to alloantigen and transplant tolerance, mainly by suppressing the activation and function of reactive effector T-cells...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27683633/current-techniques-for-ab0-incompatible-living-donor-liver-transplantation
#7
REVIEW
Silke Rummler, Astrid Bauschke, Erik Bärthel, Heike Jütte, Katrin Maier, Patrice Ziehm, Christina Malessa, Utz Settmacher
For a long time, it was considered medical malpractice to neglect the blood group system during transplantation. Because there are far more patients waiting for organs than organs available, a variety of attempts have been made to transplant AB0-incompatible (AB0i) grafts. Improvements in AB0i graft survival rates have been achieved with immunosuppression regimens and plasma treatment procedures. Nevertheless, some grafts are rejected early after AB0i living donor liver transplantation (LDLT) due to antibody mediated rejection or later biliary complications that affect the quality of life...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27683632/hemodynamic-monitoring-in-heart-failure-and-pulmonary-hypertension-from-analog-tracings-to-the-digital-age
#8
REVIEW
Ryan Davey, Amresh Raina
Hemodynamic monitoring has long formed the cornerstone of heart failure (HF) and pulmonary hypertension diagnosis and management. We review the long history of invasive hemodynamic monitors initially using pulmonary artery (PA) pressure catheters in the hospital setting, to evaluating the utility of a number of implantable devices that can allow for ambulatory determination of intracardiac pressures. Although the use of indwelling PA catheters has fallen out of favor in a number of settings, implantable devices have afforded clinicians an opportunity for objective determination of a patient's volume status and pulmonary pressures...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27683631/genetic-barriers-in-transplantation-medicine
#9
REVIEW
Hisham A Edinur, Siti M Manaf, Nor F Che Mat
The successful of transplantation is determined by the shared human leukocyte antigens (HLAs) and ABO blood group antigens between donor and recipient. In recent years, killer cell receptor [i.e., killer cell immunoglobulin-like receptor (KIR)] and major histocompatibility complex (MHC) class I chain-related gene molecule (i.e., MICA) were also reported as important determinants of transplant compatibility. At present, several different genotyping techniques (e.g., sequence specific primer and sequence based typing) can be used to characterize blood group, HLA, MICA and KIR and loci...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27683630/physical-rehabilitation-for-lung-transplant-candidates-and-recipients-an-evidence-informed-clinical-approach
#10
REVIEW
Lisa Wickerson, Dmitry Rozenberg, Tania Janaudis-Ferreira, Robin Deliva, Vincent Lo, Gary Beauchamp, Denise Helm, Chaya Gottesman, Polyana Mendes, Luciana Vieira, Margaret Herridge, Lianne G Singer, Sunita Mathur
Physical rehabilitation of lung transplant candidates and recipients plays an important in optimizing physical function prior to transplant and facilitating recovery of function post-transplant. As medical and surgical interventions in lung transplantation have evolved over time, there has been a demographic shift of individuals undergoing lung transplantation including older individuals, those with multiple co-morbidites, and candidates with respiratory failure requiring bridging to transplantation. These changes have an impact on the rehabilitation needs of lung transplant candidates and recipients...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27683629/recent-insights-in-the-pathogenesis-of-post-transplantation-lymphoproliferative-disorders
#11
REVIEW
Julie Morscio, Thomas Tousseyn
Post-transplant lymphoproliferative disorder (PTLD) is an aggressive complication of solid organ and hematopoietic stem cell transplantation that arises in up to 20% of transplant recipients. Infection or reactivation of the Epstein-Barr virus (EBV), a ubiquitous human herpesvirus, in combination with chronic immunosuppression are considered as the main predisposing factors, however insight in PTLD biology is fragmentary. The study of PTLD is complicated by its morphological heterogeneity and the lack of prospective trials, which also impede treatment optimization...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27683628/bk-nephropathy-in-the-native-kidneys-of-patients-with-organ-transplants-clinical-spectrum-of-bk-infection
#12
REVIEW
Darlene Vigil, Nikifor K Konstantinov, Marc Barry, Antonia M Harford, Karen S Servilla, Young Ho Kim, Yijuan Sun, Kavitha Ganta, Antonios H Tzamaloukas
Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy (BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27683627/cryptosporidium-infection-in-solid-organ-transplantation
#13
REVIEW
Diana F Florescu, Uriel Sandkovsky
Diarrhea is a common complication in solid organ transplant (SOT) recipients and may be attributed to immunosuppressive drugs or infectious organisms such as bacteria, viruses or parasites. Cryptosporidium usually causes self-limited diarrhea in immunocompetent hosts. Although it is estimated that cryptosporidium is involved in about 12% of cases of infectious diarrhea in developing countries and causes approximately 748000 cases each year in the United States, it is still an under recognized and important cause of infectious diarrhea in SOT recipients...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27683626/deceased-organ-donation-for-transplantation-challenges-and-opportunities
#14
EDITORIAL
Raffaele Girlanda
Organ transplantation saves thousands of lives every year but the shortage of donors is a major limiting factor to increase transplantation rates. To allow more patients to be transplanted before they die on the wait-list an increase in the number of donors is necessary. Patients with devastating irreversible brain injury, if medically suitable, are potential deceased donors and strategies are needed to successfully convert them into actual donors. Multiple steps in the process of deceased organ donation can be targeted to increase the number of organs suitable for transplant...
September 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27358792/cavitary-lung-lesion-6-years-after-renal-transplantation
#15
Arun Kumar Subbiah, Sudheer Arava, Soumita Bagchi, Karan Madan, Chandan J Das, Sanjay Kumar Agarwal
The differential diagnoses of a cavitary lung lesion in renal transplant recipients would include infection, malignancy and less commonly inflammatory diseases. Bacterial infection, Tuberculosis, Nocardiosis, fungal infections like Aspergillosis and Cryptococcosis need to be considered in these patients. Pulmonary cryptococcosis usually presents 16-21 mo after transplantation, more frequently in patients who have a high level of cumulative immunosuppression. Here we discuss an interesting patient who never received any induction/anti-rejection therapy but developed both BK virus nephropathy as well as severe pulmonary Cryptococcal infection after remaining stable for 6 years after transplantation...
June 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27358791/acute-bacterial-sternoclavicular-osteomyelitis-in-a-long-term-renal-transplant-recipient
#16
Evangelia Dounousi, Anila Duni, Sofia Xiromeriti, Charalambos Pappas, Kostas C Siamopoulos
Kidney transplantation is the treatment of choice for a significant number of patients with end-stage renal disease. Although immunosuppression therapy improves graft and patient's survival, it is a major risk factor for infection following kidney transplantation altering clinical manifestations of the infectious diseases and complicating both the diagnosis and management of renal transplant recipients (RTRs). Existing literature is very limited regarding osteomyelitis in RTRs. Sternoclavicular osteomyelitis is rare and has been mainly reported after contiguous spread of infection or direct traumatic seeding of the bacteria...
June 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27358790/islet-autotransplantation-in-a-patient-with-hypercoagulable-disorder
#17
Chirag S Desai, Khalid M Khan, Wanxing Cui
Total pancreatectomy and islet auto transplantation is a good option for chronic pancreatitis patients who suffer from significant pain, poor quality of life, and the potential of type 3C diabetes and pancreatic cancer. Portal vein thrombosis is the most feared complication of the surgery and chances are increased if the patient has a hypercoagulable disorder. We present a challenging case of islet auto transplantation from our institution. A 29-year-old woman with plasminogen activator inhibitor-4G/4G variant and a clinical history of venous thrombosis was successfully managed with a precise peri- and post-operative anticoagulation protocol...
June 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27358789/exercise-manual-for-liver-disease-patients
#18
Vivian Limongi, Daniele Costa Dos Santos, Aurea Maria de Oliveira da Silva, Ilka de Fátima Santana Ferreira Boin, Raquel Silveira Bello Stucchi
AIM: To increase inspiratory muscle strength and improve the quality of life of candidates for liver transplantation. METHODS: Twenty-three candidates for liver transplantation participated in the control group and 14 made up the intervention group. The control group consisted of 18 men and 5 women, body mass index (BMI) 27.3 ± 4.5 kg/m(2) and Model for End-Stage Liver Disease (MELD) 18.2 ± 6.1. The intervention group consisted of 11 men and 3 women, BMI 28.6 ± 5...
June 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27358788/deceased-donor-organ-procurement-injuries-in-the-united-states
#19
Tim E Taber, Nikole A Neidlinger, Muhammad A Mujtaba, Elling E Eidbo, Roxane L Cauwels, Elizabeth M Hannan, Jennifer R Miller, Anil S Paramesh
AIM: To determine the incidence of surgical injury during deceased donor organ procurements. METHODS: Organ damage was classified into three tiers, from 1-3, with the latter rendering the organ non-transplantable. For 12 consecutive months starting in January of 2014, 36 of 58 organ procurement organization's (OPO)'s prospectively submitted quality data regarding organ damage (as reported by the transplanting surgeon and confirmed by the OPO medical director) seen on the procured organ...
June 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27358787/proposal-of-new-expanded-selection-criteria-using-total-tumor-size-and-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-for-living-donor-liver-transplantation-in-patients-with-hepatocellular-carcinoma-the-national-cancer-center-korea
#20
Seung Duk Lee, Bora Lee, Seong Hoon Kim, Jungnam Joo, Seok-Ki Kim, Young-Kyu Kim, Sang-Jae Park
AIM: To expand the living donor liver transplantation (LT) pool of eligible patients with hepatocellular carcinoma (HCC) using new morphological and biological criteria. METHODS: Patients with HCC who underwent living donor LT (LDLT) from March 2005 to May 2013 at the National Cancer Center Korea (NCCK) were enrolled. We performed the (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) before LDLT. Overall and disease-free survival analysis was done in patients to evaluate the usefulness of new NCCK criteria using PET/CT and total tumor size (10 cm)...
June 24, 2016: World Journal of Transplantation
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