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Biomarker Research

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https://www.readbyqxmd.com/read/29780592/preleukemic-and-second-hit-mutational-events-in-an-acute-myeloid-leukemia-patient-with-a-novel-germline-runx1-mutation
#1
Isaac Ks Ng, Joanne Lee, Christopher Ng, Bustamin Kosmo, Lily Chiu, Elaine Seah, Michelle Meng Huang Mok, Karen Tan, Motomi Osato, Wee-Joo Chng, Benedict Yan, Lip Kun Tan
Background: Germline mutations in the RUNX1 transcription factor give rise to a rare autosomal dominant genetic condition classified under the entity: Familial Platelet Disorders with predisposition to Acute Myeloid Leukaemia (FPD/AML). While several studies have identified a myriad of germline RUNX1 mutations implicated in this disorder, second-hit mutational events are necessary for patients with hereditary thrombocytopenia to develop full-blown AML. The molecular picture behind this process remains unclear...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29713473/nkx2-2-pdx-1-and-cdx-2-as-potential-biomarkers-to-differentiate-well-differentiated-neuroendocrine-tumors
#2
Michelle X Yang, Ryan F Coates, Abiy Ambaye, Valerie Cortright, Jeannette M Mitchell, Alexa M Buskey, Richard Zubarik, James G Liu, Steven Ades, Maura M Barry
Background: Well-differentiated neuroendocrine tumors (NET) most frequently arise from the gastrointestinal tract (GI), pancreas, and lung. Patients often present as metastasis with an unknown primary, and the clinical management and outcome depend on multiple factors, including the accurate diagnosis with the tumor primary site. Determining the site of the NET with unknown primary remains challenging. Many biomarkers have been investigated in primary NETs and metastatic NETs, with heterogeneous sensitivity and specificity observed...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29651336/pi3k-p38-and-jak-stat-signalling-in-bronchial-tissue-from-patients-with-asthma-following-allergen-challenge
#3
Thomas Southworth, Sarah Mason, Alan Bell, Isabel Ramis, Marta Calbet, Anna Domenech, Neus Prats, Montserrat Miralpeix, Dave Singh
Background: Inhaled allergen challenges are often used to evaluate novel asthma treatments in early phase clinical trials. Current novel therapeutic targets in asthma include phosphoinositide 3-kinases (PI3K) delta and gamma, p38 mitogen-activated protein kinase (p38) and Janus kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signalling pathways. The activation of these pathways following allergen exposure in atopic asthma patients it is not known. Methods: We collected bronchial biopsies from 11 atopic asthma patients at baseline and after allergen challenge to investigate biomarkers of PI3K, p38 MAPK and JAK/STAT activation by immunohistochemistry...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29588856/diagnosis-of-gata2-haplo-insufficiency-in-a-young-woman-prompted-by-pancytopenia-with-deficiencies-of-b-cell-and-dendritic-cell-development
#4
Allen Sanyi, David L Jaye, Cecilia B Rosand, Amanda Box, Chandrakasan Shanmuganathan, Edmund K Waller
Background: GATA2 deficiency presents with a spectrum of phenotypes including increased susceptibility to viral and bacterial infections, multi-lineage cytopenias, aplastic anemia, leukemic transformation and lymphedema. Allogeneic transplantation is only curative therapy for GATA2 deficiency, but is associated with significant treatment related morbidity and mortality. Given the spectrum of clinical presentation, accurate diagnosis of GATA2 deficiency is necessary to identify patients early in their disease course when allogeneic bone marrow transplantation may be of clinical benefit...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29568526/erythrocyte-fatty-acid-profiles-in-children-are-not-predictive-of-autism-spectrum-disorder-status-a-case-control-study
#5
Daniel P Howsmon, James B Adams, Uwe Kruger, Elizabeth Geis, Eva Gehn, Juergen Hahn
Biomarkers promise biomolecular explanations as well as reliable diagnostics, stratification, and treatment strategies that have the potential to help mitigate the effects of disorders. While no reliable biomarker has yet been found for autism spectrum disorder (ASD), fatty acids have been investigated as potential biomarkers because of their association with brain development and neural functions. However, the ability of fatty acids to classify individuals with ASD from age/gender-matched neurotypical (NEU) peers has largely been ignored in favor of investigating population-level differences...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29564133/suitability-of-yin-yang-1-transcript-and-protein-levels-for-biomarker-studies-in-b-cell-non-hodgkin-lymphoma
#6
Jéssica Arribas Arranz, Dalia Nilufar Winter, Hans Günter Drexler, Sonja Eberth
Background: Yin Yang 1 (YY1) is a transcription factor that plays an important role during all stages of B cell differentiation. Several studies reported upregulation of YY1 in B cell derived lymphoma, indicating that it might act as an oncogene. Furthermore, aberrant YY1 expression has been associated with survival in some entities of B cell non-Hodgkin lymphoma (B-NHL), suggesting that YY1 could be a valuable biomarker in B-NHL. However, studies are controversial and methodologically disparate, partially because some studies are based on transcript levels while others rely on YY1 protein data...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29556394/epigenetic-regulation-of-cancer-progression-by-ezh2-from-biological-insights-to-therapeutic-potential
#7
REVIEW
Lu Gan, Yanan Yang, Qian Li, Yi Feng, Tianshu Liu, Weijian Guo
Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery. EZH2 also functions both as a transcriptional suppressor and a transcriptional co-activator, depending on H3K27me3 or not and on the different cellular contexts. Unsurprisingly, numerous studies have highlighted the role of EZH2 in cancer development and progression. Through modulating critical gene expression, EZH2 promotes cell survival, proliferation, epithelial to mesenchymal, invasion, and drug resistance of cancer cells...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29541473/correction-to-circulating-tumor-cell-clusters-associated-gene-plakoglobin-is-a-significant-prognostic-predictor-in-patients-with-breast-cancer
#8
W Goto, S Kashiwagi, Y Asano, K Takada, K Takahashi, T Hatano, T Takashima, S Tomita, H Motomura, M Ohsawa, K Hirakawa, M Ohira
[This corrects the article DOI: 10.1186/s40364-017-0099-2.].
2018: Biomarker Research
https://www.readbyqxmd.com/read/29456860/protein-kinase-inhibitors-for-acute-leukemia
#9
REVIEW
Yuan Ling, Qing Xie, Zikang Zhang, Hua Zhang
Conventional treatments for acute leukemia include chemotherapy, radiation therapy, and intensive combined treatments (including bone marrow transplant or stem cell transplants). Novel treatment approaches are in active development. Recently, protein kinase inhibitors are on clinical trials and offer hope as new drugs for acute leukemia treatment. This review will provide a brief summary of the protein kinase inhibitors in clinical applications for acute leukemia treatment.
2018: Biomarker Research
https://www.readbyqxmd.com/read/29456859/acute-myeloid-leukemia-in-a-father-and-son-with-a-germline-mutation-of-asxl1
#10
Karen Seiter, Kyaw Htun, Paul Baskind, Zach Liu
Background: Myelodysplastic syndromes and acute myeloid leukemia usually occur sporadically in older adults. More recently cases of familial acute myeloid leukemia and/or myelodysplastic syndrome have been reported. Case presentation: Currently we report a father and son who both developed myelodysplastic syndrome that progressed to acute myeloid leukemia. Both patients were found to have the identical mutation of ASXL1 on nextgen sequencing of both hematologic and nonhematologic tissues...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29441205/sphingosine-kinase-2-supports-the-development-of-bcr-abl-independent-acute-lymphoblastic-leukemia-in-mice
#11
Vicki Xie, Daochen Tong, Craig T Wallington-Beddoe, Ken F Bradstock, Linda J Bendall
Background: Sphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the development of acute lymphoblastic leukemia (ALL). Methods: In this and our previous study we use mouse models: in the previous study the disease was driven by the proto-oncogene BCR/ABL1, while in this study cancer risk was elevated by deletion of the tumor suppressor ARF...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29387418/comparative-analysis-of-cerebrospinal-fluid-metabolites-in-alzheimer-s-disease-and-idiopathic-normal-pressure-hydrocephalus-in-a-japanese-cohort
#12
Yuki Nagata, Akiyoshi Hirayama, Satsuki Ikeda, Aoi Shirahata, Futaba Shoji, Midori Maruyama, Mitsunori Kayano, Masahiko Bundo, Kotaro Hattori, Sumiko Yoshida, Yu-Ichi Goto, Katsuya Urakami, Tomoyoshi Soga, Kouichi Ozaki, Shumpei Niida
Background: Alzheimer's disease (AD) is a most common dementia in elderly people. Since AD symptoms resemble those of other neurodegenerative diseases, including idiopathic normal pressure hydrocephalus (iNPH), it is difficult to distinguish AD from iNPH for a precise and early diagnosis. iNPH is caused by the accumulation of cerebrospinal fluid (CSF) and involves gait disturbance, urinary incontinence, and dementia. iNPH is treatable with shunt operation which removes accumulated CSF from the brain ventricles...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29387417/biomarkers-of-cytokine-release-syndrome-and-neurotoxicity-related-to-car-t-cell-therapy
#13
REVIEW
Zhenguang Wang, Weidong Han
Severe cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T cell (CAR-T) therapy can be life-threatening in some cases, and management of those toxicities is still a great challenge for physicians. Researchers hope to understand the pathophysiology of CRS and neurotoxicity, and identify predictive biomarkers that can forecast those toxicities in advance. Some risk factors for severe CRS and/or neurotoxicity including patient and treatment characteristics have been identified in multiple clinical trials of CAR-T cell therapy...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29344362/development-of-biomarker-combinations-for-postoperative-acute-kidney-injury-via-bayesian-model-selection-in-a-multicenter-cohort-study
#14
Allison Meisner, Kathleen F Kerr, Heather Thiessen-Philbrook, Francis Perry Wilson, Amit X Garg, Michael G Shlipak, Peter Kavsak, Richard P Whitlock, Steven G Coca, Chirag R Parikh
Background: Acute kidney injury (AKI) is a frequent complication of cardiac surgery. We sought prognostic combinations of postoperative biomarkers measured within 6 h of surgery, potentially in combination with cardiopulmonary bypass time (to account for the degree of insult to the kidney). We used data from a large cohort of patients and adapted methods for developing biomarker combinations to account for the multicenter design of the study. Methods: The primary endpoint was sustained mild AKI, defined as an increase of 50% or more in serum creatinine over preoperative levels lasting at least 2 days during the hospital stay...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29344361/platelet-protein-biomarker-panel-for-ovarian-cancer-diagnosis
#15
Marta Lomnytska, Rui Pinto, Susanne Becker, Ulla Engström, Sonja Gustafsson, Christina Björklund, Markus Templin, Jan Bergstrand, Lei Xu, Jerker Widengren, Elisabeth Epstein, Bo Franzén, Gert Auer
Background: Platelets support cancer growth and spread making platelet proteins candidates in the search for biomarkers. Methods: Two-dimensional (2D) gel electrophoresis, Partial Least Squares Discriminant Analysis (PLS-DA), Western blot, DigiWest. Results: PLS-DA of platelet protein expression in 2D gels suggested differences between the International Federation of Gynaecology and Obstetrics (FIGO) stages III-IV of ovarian cancer, compared to benign adnexal lesions with a sensitivity of 96% and a specificity of 88%...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29308206/sall4-as-a-transcriptional-and-epigenetic-regulator-in-normal-and-leukemic-hematopoiesis
#16
REVIEW
Jianchang Yang
In recent years, there has been substantial progress in our knowledge of the molecular pathways by which stem cell factor SALL4 regulates the embryonic stem cell (ESC) properties, developmental events, and human cancers. This review summarizes recent advances in the biology of SALL4 with a focus on its regulatory functions in normal and leukemic hematopoiesis. In the normal hematopoietic system, expression of SALL4 is mainly enriched in the bone marrow hematopoietic stem/progenitor cells (HSCs/HPCs), but is rapidly silenced following lineage differentiation...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29255607/interleukin-10-and-soluble-tumor-necrosis-factor-receptor-ii-are-potential-biomarkers-of-plasmodium-falciparum-infections-in-pregnant-women-a-case-control-study-from-nanoro-burkina-faso
#17
E Ruizendaal, H D F H Schallig, J Bradley, M Traore-Coulibaly, P Lompo, U d'Alessandro, S Scott, F Njie, S H Zango, O Sawadogo, M D de Jong, H Tinto, P F Mens
Background: Diagnosis of malaria in pregnancy is problematic due to the low sensitivity of conventional diagnostic tests (rapid diagnostic test and microscopy), which is exacerbated due to low peripheral parasite densities, and lack of clinical symptoms. In this study, six potential biomarkers to support malaria diagnosis in pregnancy were evaluated. Methods: Blood samples were collected from pregnant women at antenatal clinic visits and at delivery. Microscopy and real-time PCR were performed for malaria diagnosis and biomarker analyses were performed by ELISA (interleukin 10, IL-10; tumor necrosis factor-α, TNF-α; soluble tumor necrosis factor receptor II, sTNF-RII; soluble fms-like tyrosine kinase 1, sFlt-1; leptin and apolipoprotein B, Apo-B)...
2017: Biomarker Research
https://www.readbyqxmd.com/read/29225884/-setbp1-mutations-as-a-biomarker-for-myelodysplasia-myeloproliferative-neoplasm-overlap-syndrome
#18
REVIEW
Katherine Linder, Chaitanya Iragavarapu, Delong Liu
Myelodysplasia (MDS) /myeloproliferative neoplasm (MPN) overlap syndrome has been described since the 2001 WHO classification as disorders that have both proliferative and dysplastic changes simultaneously. Specific disorders include chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML), BCR-ABL negative atypical chronic myeloid leukemia (aCML) and unclassifiable MDS/MPN (MPN/MDS-U). Recurrent gene mutations in these conditions have been described. Among them, SETBP1 mutations have been identified in up to 32% of aCML, 24% of JMML, 18% of CMML and 10% of MDS/MPN-U patients...
2017: Biomarker Research
https://www.readbyqxmd.com/read/29152306/evaluation-of-two-high-throughput-proteomic-technologies-for-plasma-biomarker-discovery-in-immunotherapy-treated-melanoma-patients
#19
Su Yin Lim, Jenny H Lee, Sarah J Welsh, Seong Beom Ahn, Edmond Breen, Alamgir Khan, Matteo S Carlino, Alexander M Menzies, Richard F Kefford, Richard A Scolyer, Georgina V Long, Helen Rizos
Background: Selective kinase and immune checkpoint inhibitors, and their combinations, have significantly improved the survival of patients with advanced metastatic melanoma. Not all patients will respond to treatment however, and some patients will present with significant toxicities. Hence, the identification of biomarkers is critical for the selection and management of patients receiving treatment. Biomarker discovery often involves proteomic techniques that simultaneously profile multiple proteins but few studies have compared these platforms...
2017: Biomarker Research
https://www.readbyqxmd.com/read/29152305/critical-appraisal-of-the-role-of-serum-albumin-in-cardiovascular-disease
#20
REVIEW
Shih-Chieh Chien, Chun-Yen Chen, Chao-Feng Lin, Hung-I Yeh
Concentration of serum albumin (SA), a multifunctional circulatory protein, is influenced by several factors, including its synthesis rate, catabolism rate, extravascular distribution, and exogenous loss. Moreover, both nutritional status and systemic inflammation affect the synthesis of SA. Determining SA concentration aids in risk prediction in various clinical settings. It is of interest to understand the prognostic value of SA in the full spectrum of cardiovascular disease (CVD) in the era of newly developed pharmacological and interventional treatments...
2017: Biomarker Research
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