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Biomarker Research

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https://www.readbyqxmd.com/read/28018598/cd34-and-cd38-are-prognostic-biomarkers-for-acute-b-lymphoblastic-leukemia
#1
REVIEW
Zhiwu Jiang, Di Wu, Shouheng Lin, Peng Li
CD34 and CD38 proteins are usually used as surface markers to identify HSCs and Leukemic stem cells. However, there have been cases that lacked CD34 or CD38 protein but still had leukemia initiating capacity in B-ALL suggesting the restrictive of these two markers. CD34 and CD38 expression were detected in most B-ALL and can serve as a specific biomarker for the prognosis of this subset of leukemia. Lack of CD34 or high CD38 expression is associated with favorable prognosis.
2016: Biomarker Research
https://www.readbyqxmd.com/read/27999674/development-and-validation-of-a-novel-bioassay-to-determine-glucocorticoid-sensitivity
#2
Emily L Williams, Madeleine L Stimpson, Peter L Collins, Doyo G Enki, Ashish Sinha, Richard W Lee, Ashwin D Dhanda
BACKGROUND: Glucocorticoids (GCs) remain the first line treatment for almost all non-infectious inflammatory diseases, ranging from acute asthma to rheumatoid arthritis. However, across all conditions, patients have a variable response to GCs with approximately 30% being non-responders. This group of GC resistant patients is typically exposed to high-dose GCs and their side-effects before more appropriate immunotherapy is instituted. Hence, there is a pressing clinical need for a predictive biomarker of GC responsiveness...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27999673/application-of-multi-target-phytotherapeutic-concept-in-malaria-drug-discovery-a-systems-biology-approach-in-biomarker-identification
#3
REVIEW
Protus Arrey Tarkang, Regina Appiah-Opong, Michael F Ofori, Lawrence S Ayong, Alexander K Nyarko
There is an urgent need for new anti-malaria drugs with broad therapeutic potential and novel mode of action, for effective treatment and to overcome emerging drug resistance. Plant-derived anti-malarials remain a significant source of bioactive molecules in this regard. The multicomponent formulation forms the basis of phytotherapy. Mechanistic reasons for the poly-pharmacological effects of plants constitute increased bioavailability, interference with cellular transport processes, activation of pro-drugs/deactivation of active compounds to inactive metabolites and action of synergistic partners at different points of the same signaling cascade...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27999672/dental-implant-bioactive-surface-modifications-and-their-effects-on-osseointegration-a-review
#4
REVIEW
Hsiu-Wan Meng, Esther Yun Chien, Hua-Hong Chien
BACKGROUND: The purpose of this article is to review and update the current developments of biologically active dental implant surfaces and their effect on osseointegration. METHODS: PubMed was searched for entries from January 2006 to January 2016. Only in-vivo studies that evaluated the effects of biomolecular coatings on titanium dental implants inserted into the bone of animals or humans were included. RESULTS: Thirty four non-review studies provided data and observations were included in this review...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27999671/plasma-microrna-biomarker-detection-for-mild-cognitive-impairment-using-differential-correlation-analysis
#5
Mitsunori Kayano, Sayuri Higaki, Jun-Ichi Satoh, Kenji Matsumoto, Etsuro Matsubara, Osamu Takikawa, Shumpei Niida
BACKGROUND: Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia including Alzheimer's disease. Early detection of dementia, and MCI, is a crucial issue in terms of secondary prevention. Blood biomarker detection is a possible way for early detection of MCI. Although disease biomarkers are detected by, in general, using single molecular analysis such as t-test, another possible approach is based on interaction between molecules. RESULTS: Differential correlation analysis, which detects difference on correlation of two variables in case/control study, was carried out to plasma microRNA (miRNA) expression profiles of 30 age- and race-matched controls and 23 Japanese MCI patients...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27895916/mechanically-produced-schistosomula-as-a-higher-throughput-tools-for-phenotypic-pre-screening-in-drug-sensitivity-assays-current-research-and-future-trends
#6
REVIEW
Emmanuel Mouafo Tekwu, William Kofi Anyan, Daniel Boamah, Kofi Owusu Baffour-Awuah, Stephanie Keyetat Tekwu, Veronique Penlap Beng, Alexander Kwadwo Nyarko, Kwabena Mante Bosompem
It is crucial to develop new antischistosomal drugs since there is no vaccine and the whole world is relying on only a single drug for the treatment of schistosomiasis. One of the obstacles to the development of drugs is the absence of the high throughput objective screening methods to assess drug compounds efficacy. Thus for identification of new drug compounds candidates, fast and accurate in vitro assays are unavoidable and more research efforts in the field of drug discovery can target schistosomula. This review presents a substantial overview of the present state of in vitro drug sensitivity assays developed so far for the determination of anti-schistosomula activity of drug compounds, natural products and derivatives using newly transformed schistosomula (NTS)...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27795830/advance-in-microrna-as-a-potential-biomarker-for-early-detection-of-pancreatic-cancer
#7
REVIEW
Jing Huang, Jianzhou Liu, Kevin Chen-Xiao, Xuemei Zhang, W N Paul Lee, Vay Liang W Go, Gary Guishan Xiao
Pancreatic cancer is characterized as a disease with low survival and high mortality because of no effective diagnostic and therapeutic strategies available in clinic. Conventional clinical diagnostic methods including serum markers and radiological imaging (CT, MRI, EUS, etc.) often fail to detect precancerous or early stage lesions. Development of effective biomarkers is unmet for reduction of mortality of pancreatic cancer. MicroRNAs (miRNAs) are a group of small non-protein-coding RNAs playing roles in regulation of cell physiology including tumorigenesis, apoptotic escape, proliferation, invasion, epithelial-mesenchymal transition (EMT), metastasis and chemoresistance...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27777768/jak2-v617f-mutation-multiple-hematologic-and-non-hematologic-processes-an-association
#8
Kenneth G Liu, Amit Verma, Olga Derman, Noah Kornblum, Murali Janakiram, Ira Braunschweig, Ramakrishna Battini
BACKGROUND: Population studies showed that patients with JAK2 V617F mutation had increased mortality, and increased risk of any cancer, hematologic cancer, and myeloproliferative disease. CASE PRESENTATION: A 68-year-old Asian male with JAK2 V617F mutation developed four different hematologic and non-hematologic neoplastic processes. In 2009, he was diagnosed with stage IA lung adenocarcinoma and also noted to have worsening leukocytosis and thrombocytosis with peak platelet count of 1,054,000/mL)...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27651903/hypercalcemia-associated-with-isolated-bone-marrow-sarcoidosis-in-a-patient-with-underlying-monoclonal-gammopathy-of-undetermined-significance-case-report-and-review-of-literature
#9
John Gubatan, Xiaohui Wang, Abner Louissaint, Anuj Mahindra, John Vanderpool
BACKGROUND: Bone marrow sarcoidosis is extremely rare. The association between sarcoidosis and lymphoproliferative disorders has been previously speculated, although the diagnosis of sarcoidosis often precedes any hematological derangements. CASE PRESENTATION: Here, we report for the first time, a case of a 57-year-old Caucasian woman with a previous diagnosis of monoclonal gammopathy of undetermined significance (MGUS) developing hypercalcemia and renal failure with workup notable for isolated bone marrow sarcoidosis and not multiple myeloma as expected...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27595000/extramedullary-hematopoiesis-presented-as-cytopenia-and-massive-paraspinal-masses-leading-to-cord-compression-in-a-patient-with-hereditary-persistence-of-fetal-hemoglobin
#10
Tasleem Katchi, Krishna Kolandaivel, Pallavi Khattar, Taliya Farooq, Humayun Islam, Delong Liu
BACKGROUND: Extramedullary hematopoeisis (EMH) can occur in various physiological and pathologic states. The spleen is the most common site of EMH. CASE PRESENTATION: We report a case with hereditary persistence of fetal hemoglobin with extramedullary hematopoiesis presented as cord compression and cytopenia secondary to multi-paraspinal masses. CONCLUSION: Treatment can be a challenge. Relapse is a possibility.
2016: Biomarker Research
https://www.readbyqxmd.com/read/27570624/a-novel-three-way-rearrangement-involving-etv6-12p13-and-abl1-9q34-with-an-unknown-partner-on-3p25-resulting-in-a-possible-etv6-abl1-fusion-in-a-patient-with-acute-myeloid-leukemia-a-case-report-and-a-review-of-the-literature
#11
Carlos A Tirado, Ken Siangchin, David S Shabsovich, Maryam Sharifian, Gary Schiller
BACKGROUND: Acute myeloid leukemia (AML) is commonly characterized by several chromosomal abnormalities resulting in the formation of chimeric genes that play various roles in leukemogenesis. Translocations resulting in the ETV6-ABL1 fusion gene are rare in AML and other hematologic malignancies with only thirty-two previously reported cases in the literature, five of which were AML. FINDINGS: Herein, we report the case of a 73-year-old male with acute myeloid leukemia arising from MDS, negative for PDGFRA and PDGFRB, positive for bone marrow eosinophilia, rash, and marked fluid retention, which improved dramatically with imatinib therapy...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27468353/gastric-mucosa-associated-lymphoid-tissue-lymphoma-and-helicobacter-pylori-infection-a-review-of-current-diagnosis-and-management
#12
REVIEW
Qinglong Hu, Yizhuo Zhang, Xiaoyan Zhang, Kai Fu
Helicobacter pylori (H. pylori)-associated gastritis is one of the most common infectious diseases in the United States, China and worldwide. Gastric mucosa-associated tissue lymphoma (MALT lymphoma) is a rare mature B-cell neoplasm associated with H. pylori infection that is curable by antibiotics therapy alone. The pathological diagnosis of gastric MALT lymphoma can be reached by histological examination, immunohistochemical staining and B-cell clonality analysis. H. pylori eradication is the choice of therapy for early-stage gastric MALT lymphoma...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27453784/pediatric-chronic-myeloid-leukemia-with-inv-3-q21q26-2-and-t-lymphoblastic-transformation-a-case-report
#13
Margaret Lewen, Renee Gresh, Maria Queenan, Michele Paessler, Vinodh Pillai, Elizabeth Hexner, Dale Frank, Adam Bagg, Richard Aplenc, Emi Caywood, Gerald Wertheim
BACKGROUND: Chronic myeloid leukemia (CML) comprises ~3 % of pediatric leukemia. Although therapy with tyrosine kinase inhibitors (TKIs) is highly effective for CML, multiple factors have been identified as predictive of treatment failure. Chromosomal abnormalities involving the MECOM locus at 3q26 portend therapy resistant disease in adults, yet have never been described in pediatric patients and have not been associated with T lymphoblastic progression. CASE PRESENTATION: We present a case of an 11-year-old boy with CML possessing the unique combination of T lymphoblastic transformation and a subclone harboring inv(3)(q21q26...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27340553/the-effect-of-n-3-polyunsaturated-fatty-acids-on-incidence-and-severity-of-oxaliplatin-induced-peripheral-neuropathy-a-randomized-controlled-trial
#14
Ali Esfahani, Mohammad Hossein Somi, Hormoz Ayromlou, Alireza Nikanfar, Mohammad Asghari Jafarabadi, Bina Eftekhar Sadat, Zohreh Ghoreishi
BACKGROUND: Oxaliplatin induced peripheral neurotoxicity (OXIPN) is the major dose-limiting and long-lasting side effect of oxaliplatin. N-3 PUFAs have neuroprotective property via their effects on voltage-gated ion channels and by reducing the production of proinflammatory cytokines that causes neuropathy. This study was a randomized double blind placebo controlled trial to find the possible advantages of n-3 PUFAs for preventing and reducing the severity of OXIPN in patients with colon cancer...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27307990/the-cxcr4-antagonist-plerixafor-enhances-the-effect-of-rituximab-in-diffuse-large-b-cell-lymphoma-cell-lines
#15
Linn Reinholdt, Maria Bach Laursen, Alexander Schmitz, Julie Støve Bødker, Lasse Hjort Jakobsen, Martin Bøgsted, Hans Erik Johnsen, Karen Dybkær
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease with variable clinical outcome, accounting for at least 25-30 % of adult non-Hodgkin lymphomas. Approximately one third of DLBCL patients are not cured by the currently used treatment regimen, R-CHOP. Hence, new treatment strategies are needed. Antagonizing the CXCR4 receptor might be promising since the CXCR4-CXCL12 axis is implicated in several aspects of tumor pathogenesis as well as in protection from chemotherapeutic response...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27252855/identification-of-functional-metabolic-biomarkers-from-lung-cancer-patient-serum-using-pep-technology
#16
Zhenyu Sun, Xiaofeng Chen, Gan Wang, Liang Li, Guofeng Fu, Matthew Kuruc, Xing Wang
BACKGROUND: Reprogrammed metabolism is a new hallmark of cancer. In many types of cancer, most of the genes in the glycolytic pathway are overexpressed, reflecting an essential shift of metabolism during cancer development. The reprogrammed metabolism contributes to cancer development in multiple ways, from supplying the elevated energy requirement to creating a microenvironment suitable for tumor growth and suppressing the human immune surveillance system. METHOD: In this study, a functional proteomics top-down approach was used to systematically monitor metabolic enzyme activities in resolved serum proteins produced by a modified 2-D gel separation and subsequent Protein Elution Plate, a method collectively called PEP...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27186374/expression-of-ifitm1-as-a-prognostic-biomarker-in-resected-gastric-and-esophageal-adenocarcinoma
#17
David Borg, Charlotta Hedner, Alexander Gaber, Björn Nodin, Richard Fristedt, Karin Jirström, Jakob Eberhard, Anders Johnsson
BACKGROUND: There is an increasing amount of reports on IFITM1 (interferon-inducible transmembrane protein 1) in various malignancies. The aim of this study was to examine the expression of IFITM1 and its prognostic significance in gastroesophageal adenocarcinoma. METHODS: Tissue samples were obtained from a consecutive cohort of 174 patients surgically treated between 2006 and 2010 for gastroesophageal (gastric, gastroesophageal junction and esophageal) adenocarcinoma, not subjected to neoadjuvant therapy...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27152197/evaluation-of-caspase-9b-and-pp2ac%C3%AE-2-as-potential-biomarkers-for-chronic-lymphocytic-leukemia
#18
Leticia Domínguez-Berrocal, Xiguang Zhang, Jean Marc Zini, Jesús Fominaya, Angelita Rebollo, Jerónimo Bravo
BACKGROUND: Disruption of alternative splicing in apoptotic factors has been associated to chronic lymphocytic leukemia among other cancers and hematological malignancies. The proapoptotic proteins Caspase-9 and PP2Acα are functionally related in a direct interaction, which constitutes a promising target for cancer therapy. Both proteins present aberrant mRNA splicing variants that are antiapoptotic (Caspase-9b) and catalytically inactive (PP2Acα2), respectively. RESULTS: In this work we have analyzed the relative abundance of the aberrant spliced forms Caspase-9b and PP2Acα2 in several cell lines and chronic lymphocytic leukemia patients and correlated it with several parameters of the disease...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27057311/the-combinatorial-approach-of-laser-captured-microdissection-and-reverse-transcription-quantitative-polymerase-chain-reaction-accurately-determines-her2-status-in-breast-cancer
#19
Elisabeth Hofmann, Rita Seeboeck, Nico Jacobi, Peter Obrist, Samuel Huter, Christian Klein, Kamil Oender, Christoph Wiesner, Harald Hundsberger, Andreas Eger
BACKGROUND: HER2 expression in breast cancer correlates with increased metastatic potential, higher tumor recurrence rates and improved response to targeted therapies. Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) are two methods commonly used for the analysis of HER2 in the clinic. However, lack of standardization, technical variability in laboratory protocols and subjective interpretation are major problems associated with these testing procedures. METHODS: Here we evaluated the applicability of reverse-transcription quantitative polymerase chain reaction (RT-qPCR) for HER2 testing in breast cancer...
2016: Biomarker Research
https://www.readbyqxmd.com/read/26966541/treatment-with-rituximab-and-brentuximab-vedotin-in-a-patient-of-common-variable-immune-deficiency-associated-classic-hodgkin-lymphoma
#20
Efren Rael, Kevin Rakszawski, Kristian Koller, Michael Bayerl, Manish Butte, Hong Zheng
BACKGROUND: Patients with common variable immunodeficiency (CVID) have an increased risk of developing lymphoproliferative diseases, including non-Hodgkins lymphoma (Blood 116:1228-1234, 2010; Blood 119:1650-7, 2012). The incidence and prognosis of Hodgkin lymphoma in this population is not clear, with only a few case reports in the literature. Conventional cytotoxic chemotherapy, although highly efficacious in treating Hodgkin lymphoma in immune competent patients, is problematic in patients with CVID due to the increased risk of infectious complications (Ther Umsch 69:687-91, 2012; Pediatr Hematol Oncol 24:337-42, 2012)...
2016: Biomarker Research
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