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Prostate International

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https://www.readbyqxmd.com/read/29556488/lipid-associated-antioxidants-arylesterase-and-paraoxonase-1-in-benign-prostatic-hyperplasia-treatment-na%C3%A3-ve-patients
#1
George Awuku Asare, Sabina Ekua Andam, Henry Asare-Anane, Seth Ammanquah, Yvonne Anang-Quartey, Daniel K Afriyie, Iddis Musah
Background: Oxidative stress and antioxidants have been implicated in many diseases including prostate cancer and benign prostatic hyperplasia (BPH). Lipid peroxidation contributes to oxidative stress. However, new and emerging antioxidants such as paraoxonase 1 (PON1) and arylesterase (ARE) associated with lipoprotein peroxidation have not been examined in BPH patients. PON1 and ARE, a high-density lipoprotein (HDL) cholesterol-bound enzyme system of antioxidants, protect low-density lipoprotein (LDL) cholesterol and HDL from oxidation by hydrolysis...
March 2018: Prostate International
https://www.readbyqxmd.com/read/29556487/survival-outcomes-of-younger-men-55-years-undergoing-radical-prostatectomy
#2
Lynn Tan, Luke L Wang, Weranja Ranasinghe, Raj Persad, Damien Bolton, Nathan Lawrentschuk, Shomik Sengupta
Background: The aim of the paper is to investigate the outcomes of patients younger than 55 years in Victoria, Australia undergoing radical prostatectomy (RP) for prostate cancer. Materials and methods: Data on all men undergoing RP in Victoria between January 1, 2004 and December 31, 2014 were obtained from the Victorian Cancer Registry. Tumor characteristics including Gleason grade, stage of disease (based on final pathology specimen), and cause of death were also obtained...
March 2018: Prostate International
https://www.readbyqxmd.com/read/29556486/differences-in-clinical-outcome-between-docetaxel-and-abiraterone-acetate-as-the-first-line-treatment-in-chemo-na%C3%A3-ve-metastatic-castration-resistant-prostate-cancer-patients-with-or-without-the-ineligible-clinical-factors-of-the-cou-aa-302-study
#3
Darren M C Poon, Kuen Chan, Siu H Lee, Tim W Chan, Henry Sze, Eric K C Lee, Daisy Lam, Michelle F T Chan
Background: This study aimed to compare the efficacy of abiraterone acetate (AA) versus docetaxel (T) as first-line treatment in chemo-naïve metastatic castration-resistant prostate cancer (mCRPC) patients with or without the ineligible factors of the COU-AA-302 study (presence of visceral metastases, symptomatic disease, and/or Eastern Cooperative Oncology Group performance status ≥ 2). Materials and methods: The clinical records of chemo-naïve mCRPC patients who received AA in six public oncology centers or T in two of these centers between 2003 and 2014 were reviewed...
March 2018: Prostate International
https://www.readbyqxmd.com/read/29556485/early-abiraterone-acetate-treatment-is-beneficial-in-japanese-castration-resistant-prostate-cancer-after-failure-of-primary-combined-androgen-blockade
#4
Takashi Nagai, Taku Naiki, Keitaro Iida, Toshiki Etani, Ryosuke Ando, Shuzo Hamamoto, Yosuke Sugiyama, Hidetoshi Akita, Hiroki Kubota, Yoshihiro Hashimoto, Noriyasu Kawai, Takahiro Yasui
Background: Development of novel agents targeting the androgen axis has led to improved overall survival in castration-resistant prostate cancer (CRPC). This study aimed to investigate the optimal timing of treatment with one such agent, abiraterone acetate (AA), in Japanese patients. Materials and methods: Between July 2014 and February 2016, 106 CRPC patients were administered AA in Nagoya City University Hospital, Nagoya, Japan and in four affiliated hospitals following failure of primary combined androgen blockade (CAB)...
March 2018: Prostate International
https://www.readbyqxmd.com/read/29556484/discrimination-of-local-recurrence-after-radical-prostatectomy-value-of-diffusion-weighted-magnetic-resonance-imaging
#5
Taekmin Kwon, Jeong Kon Kim, Chanwoo Lee, Jaeyoon Jung, Hanjong Ahn, Choung-Soo Kim, Jun Hyuk Hong
Background: Multiparametric magnetic resonance is the most accurate imaging technique for prostate cancer detection, staging, localization, and aggressiveness evaluation. We assessed accuracy of diffusion-weighted imaging in local recurrence diagnosis after radical prostatectomy. Materials and methods: A retrospective study was conducted in 118 patients with findings suggestive of local recurrence in dynamic contrast-enhanced-magnetic resonance imaging. Local recurrence was defined clinically as a rising prostate-specific antigen level (biochemical recurrence) without radiographic evidence of distant metastasis over 6 months after surgery...
March 2018: Prostate International
https://www.readbyqxmd.com/read/29556483/background-factors-and-short-term-health-related-quality-of-life-in-patients-who-initially-underwent-radical-prostatectomy-or-androgen-deprivation-therapy-for-localized-prostate-cancer-in-a-japanese-prospective-observational-study-j-cap-innovative-study-1
#6
Satoru Ueno, Yasuhide Kitagawa, Mizuki Onozawa, Shiro Hinotsu, Hideyuki Akaza, Atsushi Mizokami, Mikio Namiki
Background: This prospective observational study elucidated the usefulness of hormonal therapy for localized prostate cancer. Background factors and the health-related quality of life in patients who initially underwent radical prostatectomy (RP) or primary androgen deprivation therapy (PADT) for localized prostate cancer are summarized. Materials and methods: Patients aged 67-76 years with clinical stage T1c or T2 localized prostate cancer treated with PADT or RP, a prostate-specific antigen concentration of <20 ng/mL, and Gleason score of ≤7 were included...
March 2018: Prostate International
https://www.readbyqxmd.com/read/29556482/reporting-and-ideal-testosterone-levels-in-men-undergoing-androgen-deprivation-for-prostate-cancer-time-for-a-rethink
#7
REVIEW
Sonja Cabarkapa, Marlon Perera, Ken Sikaris, Jonathan S O'Brien, Damien M Bolton, Nathan Lawrentschuk
Background: This study aims to review current laboratory reporting strategies across Australia and New Zealand with a view to propose a more useful template for reporting serum testosterone in the context of prostate cancer. Materials and methods: Registered pathology laboratories in Australia and New Zealand were enrolled into the current study. An electronic or a phone survey was utilized to collect data from each participating laboratory. Obtained information included assay utilized, units reported, reference intervals, lowest reported value, and lowest detectable value...
March 2018: Prostate International
https://www.readbyqxmd.com/read/29188203/comparison-of-visual-prostate-symptom-score-and-international-prostate-symptom-score-in-the-evaluation-of-men-with-benign-prostatic-hyperplasia-a-prospective-study-from-an-indian-population
#8
Yogesh Taneja, Priyatama Ram, Satish Kumar, Kishan Raj, Charan K Singh, Santosh K Dhaked, Jiten Jaipuria
Background: Lower urinary tract symptoms (LUTSs) due to benign prostatic hyperplasia (BPH) are common conditions in middle-age or older men. The International Prostate Symptom Score (IPSS) is a useful and validated questionnaire to evaluate LUTS secondary to BPH. Van der Walt et al have developed an alternative questionnaire named the Visual Prostate Symptom Score (VPSS) questionnaire. This study aimed to evaluate the relationship between the VPSS and IPSS in the evaluation of men with LUTSs due to BPH in an Indian population...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29188202/seminal-plasma-enables-selection-and-monitoring-of-active-surveillance-candidates-using-nuclear-magnetic-resonance-based-metabolomics-a-preliminary-investigation
#9
Matthew J Roberts, Renee S Richards, Clement W K Chow, Marion Buck, John Yaxley, Martin F Lavin, Horst Joachim Schirra, Robert A Gardiner
Background: Diagnosis and monitoring of localized prostate cancer requires discovery and validation of noninvasive biomarkers. Nuclear magnetic resonance (NMR)-based metabolomics of seminal plasma reportedly improves diagnostic accuracy, but requires validation in a high-risk clinical cohort. Materials and methods: Seminal plasma samples of 151 men being investigated for prostate cancer were analyzed with1 H-NMR spectroscopy. After adjustment for buffer (add-to-subtract) and endogenous enzyme influence on metabolites, metabolite profiling was performed with multivariate statistical analysis (principal components analysis, partial least squares) and targeted quantitation...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29188201/significant-prognostic-difference-between-grade-group-4-and-5-in-the-2014-international-society-of-urological-pathology-grading-system-for-high-grade-prostate-cancer-with-bone-metastasis
#10
Yasutaka Yamada, Shinichi Sakamoto, Jun Shimazaki, Masahiro Sugiura, Yoshiyasu Amiya, Makoto Sasaki, Takayuki Shima, Akira Komiya, Noriyuki Suzuki, Koichiro Akakura, Tomohiko Ichikawa, Hiroomi Nakatsu
Background: To investigate prognostic difference between Gleason Score (GS) 8 and 9-10, as the 2014 International Society of Urological Pathology Gleason Grading Systems proposed, in patients with prostate cancer (PCa) with bone metastasis. Materials and methods: We retrospectively reviewed data on 106 patients with GS 8-10 between 2006 and 2016. All patients received androgen deprivation therapy immediately. We validated biochemical recurrence, PCa-specific survival, and overall survival, and analyzed the predictive value for overall survival...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29188200/management-and-outcomes-of-gleason-six-prostate-cancer-detected-on-needle-biopsy-a-single-surgeon-experience-over-6-years
#11
Brayden March, George Koufogiannis, Mark Louie-Johnsun
Objective: To assess the management and oncological outcomes in men diagnosed with Gleason score (GS) 6 prostate cancer on needle biopsy in a regional centre, as compared with published international data. Materials and methods: A retrospective analysis was conducted of patients who were diagnosed with GS 6 prostate cancer via transrectal ultrasound-guided or transperineal biopsy between June 2009 and September 2015 under the care of a single surgeon. Data were obtained from a prospectively collected database...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29188199/effects-of-25-and-30-degree-trendelenburg-positions-on-intraocular-pressure-changes-during-robot-assisted-radical-prostatectomy
#12
Masatomo Nishikawa, Hiromitsu Watanabe, Tomofumi Kurahashi
Background: The objective of this study was to assess the effects of 25-degree and 30-degree Trendelenburg positions on intraocular pressure (IOP) changes during robot-assisted radical prostatectomy (RARP). Materials and methods: This prospective study involved a total of 30 consecutive patients undergoing RARP. All participants were randomly divided into two groups: Trendelenburg position with the head down at 25 degrees or 30 degrees. In addition to representative operative outcomes, IOP was measured at six discrete time points; Time 1 (T1): before induction of general anesthesia, patients in a horizontal supine position; T2: after induction of general anesthesia, patients in a horizontal supine position; T3: 1 hour after adopting the Trendelenburg position; T4: 2 hours after adopting the Trendelenburg position; T5: after pneumoperitoneum resolution in the Trendelenburg position; T6: anesthetized before awakening in a supine position...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29188198/evaluation-of-the-changing-landscape-of-prostate-cancer-diagnosis-and-management-from-2005-to-2016
#13
Kirsten R Carlaw, Henry H Woo
Background: Approaches to prostate cancer (PCa) diagnosis and treatment have evolved significantly over past decades. There has been an increasing focus on minimizing overdiagnosis and overtreatment of clinically insignificant PCa. The objective of this study was to evaluate the changes in the diagnostic approach and initial treatment strategy that has evolved over time in an Australian urological private practice. Materials and methods: Men with newly diagnosed PCa were identified from the private practice electronic and paper medical records from 2005 to 2016 and data was consolidated into six groups of 2-year intervals...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29188197/-68-ga-prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography-in-advanced-prostate-cancer-current-state-and-future-trends
#14
REVIEW
Cristian Udovicich, Marlon Perera, Michael S Hofman, Shankar Siva, Andres Del Rio, Declan G Murphy, Nathan Lawrentschuk
The early and accurate detection of prostate cancer is important to ensure timely management and appropriate individualized treatment. Currently, conventional imaging has limitations particularly in the early detection of metastases and at prostate-specific antigen (PSA) levels < 2.0 ng/mL. Furthermore, disease management such as salvage radiotherapy is best at low PSA levels. Thus, it is critical to capture the disease in the oligometastatic stage as disease progression and commencement of systemic therapies can be delayed by metastasis-directed therapy...
December 2017: Prostate International
https://www.readbyqxmd.com/read/28828356/relation-between-histological-prostatitis-and-lower-urinary-tract-symptoms-and-erectile-function
#15
Taiki Mizuno, Ippei Hiramatsu, Yusuke Aoki, Hirofumi Shimoyama, Taiji Nozaki, Masato Shirai, Yan Lu, Shigeo Horie, Akira Tsujimura
BACKGROUND: Chronic prostatitis (CP) significantly worsens a patient's quality of life (QOL), but its etiology is heterogeneous. Although the inflammatory process must be associated with CP symptoms, not all patients with benign prostatic hyperplasia and histological prostatitis complain of CP symptoms. The relation between the severity of histological inflammation and lower urinary tract symptoms (LUTS) and erectile function is not fully understood. METHODS: This study comprised 26 men with suspected prostate cancer but with no malignant lesion by pathological examination of prostate biopsy specimens...
September 2017: Prostate International
https://www.readbyqxmd.com/read/28828355/efficacy-and-safety-of-silodosin-in-the-treatment-of-lower-urinary-tract-symptoms-in-elderly-men-taking-antihypertensive-medications
#16
Woo Suk Choi, Min Chul Cho, Jeong Woo Lee, Sang Hoon Song, Jin Kyu Oh, Sang Wook Lee, Sung Yong Cho, Jae Young Park
BACKGROUND: Both hypertension and lower urinary tract symptoms (LUTS) are common conditions in the elderly population. This study investigated the efficacy and safety of silodosin in the treatment of LUTS in elderly men who were taking antihypertensive medications. METHODS: This is an observational study which collected the medical records of patients who started silodosin medication for their LUTS between April 2015 and December 2015. Inclusion criteria were age ≥ 65 years, currently taking antihypertensive medication, and International Prostate Symptom Score (IPSS) ≥ 8...
September 2017: Prostate International
https://www.readbyqxmd.com/read/28828354/fibrinogen-and-d-dimer-levels-in-prostate-cancer-preliminary-results
#17
Selahattin Çalışkan, Mustafa Sungur
BACKGROUND: Prostate cancer is one of the most common malignancy in men. The main risk factors for coagulation activation and thrombosis are malignancy and older age. The thrombosis risk may be associated with increased level of coagulation markers such as fibrinogen and D-dimer. The aim of this study is evaluate the relationship between coagulation markers and prostate cancer. METHODS: This prospective study includes the patients who underwent transrectal ultrasound guided prostate biopsy and prostate surgery was performed between January 2015 and January 2016...
September 2017: Prostate International
https://www.readbyqxmd.com/read/28828353/impact-of-poor-glycemic-control-of-type-2-diabetes-mellitus-on-serum-prostate-specific-antigen-concentrations-in-men
#18
Hasan Anıl Atalay, Murat Akarsu, Lutfi Canat, Volkan Ülker, İlter Alkan, Unsal Ozkuvancı
BACKGROUND: To evaluate the impact of poor glycemic control of type 2 diabetes mellitus (T2DM) on serum prostate-specific antigen (PSA) concentrations in men. METHODS: We performed a prospective analysis of 215 consecutive patients affected by erectile dysfunction (ED). ED was evaluated using the IIEF-5 questionnaire and the poor glycemic control (PGC) of T2DM was assessed according to the HbA1c criteria (International Diabetes Federation). Patients were divided into PGC group (HbA1c ≥ 7%) and control group (CG) (HbA1c < 6%)...
September 2017: Prostate International
https://www.readbyqxmd.com/read/28828352/report-of-the-second-asian-prostate-cancer-a-cap-study-meeting
#19
Choung-Soo Kim, Ji Youl Lee, Byung Ha Chung, Wun-Jae Kim, Ng Chi Fai, Lukman Hakim, Rainy Umbas, Teng Aik Ong, Jasmine Lim, Jason L Letran, Edmund Chiong, Tong-Lin Wu, Bannakij Lojanapiwat, Levent Türkeri, Declan G Murphy, Robert A Gardiner, Kim Moretti, Matthew Cooperberg, Peter Carroll, Seong Ki Mun, Shiro Hinotsu, Yoshihiko Hirao, Seiichiro Ozono, Shigeo Horie, Mizuki Onozawa, Yasuhide Kitagawa, Tadaichi Kitamura, Mikio Namiki, Hideyuki Akaza
The Asian Prostate Cancer (A-CaP) Study is an Asia-wide initiative that has been developed over the course of 2 years. The study was launched in December 2015 in Tokyo, Japan, and the participating countries and regions engaged in preparations for the study during the course of 2016, including patient registration and creation of databases for the purpose of the study. The Second A-CaP Meeting was held on September 8, 2016 in Seoul, Korea, with the participation of members and collaborators from 12 countries and regions...
September 2017: Prostate International
https://www.readbyqxmd.com/read/28828351/characteristics-and-national-trends-of-patients-receiving-treatment-of-the-primary-tumor-for-metastatic-prostate-cancer
#20
Sumi Sinha, Vinayak Muralidhar, Felix Y Feng, Paul L Nguyen
BACKGROUND: We sought to determine temporal trends in the receipt of prostatectomy or locoregional radiation to the prostate for patients with metastatic prostate cancer and to identify predictors of receipt of local treatment. METHODS: We identified 39,976 patients with metastatic prostate cancer diagnosed in 2004-2012 using the National Cancer Database (NCDB). We used logistic multivariable regression to determine trends in the receipt of prostate and/or pelvic radiation or radical prostatectomy after adjusting for demographic and clinical factors...
September 2017: Prostate International
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