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Prostate International

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https://www.readbyqxmd.com/read/28828356/relation-between-histological-prostatitis-and-lower-urinary-tract-symptoms-and-erectile-function
#1
Taiki Mizuno, Ippei Hiramatsu, Yusuke Aoki, Hirofumi Shimoyama, Taiji Nozaki, Masato Shirai, Yan Lu, Shigeo Horie, Akira Tsujimura
BACKGROUND: Chronic prostatitis (CP) significantly worsens a patient's quality of life (QOL), but its etiology is heterogeneous. Although the inflammatory process must be associated with CP symptoms, not all patients with benign prostatic hyperplasia and histological prostatitis complain of CP symptoms. The relation between the severity of histological inflammation and lower urinary tract symptoms (LUTS) and erectile function is not fully understood. METHODS: This study comprised 26 men with suspected prostate cancer but with no malignant lesion by pathological examination of prostate biopsy specimens...
September 2017: Prostate International
https://www.readbyqxmd.com/read/28828355/efficacy-and-safety-of-silodosin-in-the-treatment-of-lower-urinary-tract-symptoms-in-elderly-men-taking-antihypertensive-medications
#2
Woo Suk Choi, Min Chul Cho, Jeong Woo Lee, Sang Hoon Song, Jin Kyu Oh, Sang Wook Lee, Sung Yong Cho, Jae Young Park
BACKGROUND: Both hypertension and lower urinary tract symptoms (LUTS) are common conditions in the elderly population. This study investigated the efficacy and safety of silodosin in the treatment of LUTS in elderly men who were taking antihypertensive medications. METHODS: This is an observational study which collected the medical records of patients who started silodosin medication for their LUTS between April 2015 and December 2015. Inclusion criteria were age ≥ 65 years, currently taking antihypertensive medication, and International Prostate Symptom Score (IPSS) ≥ 8...
September 2017: Prostate International
https://www.readbyqxmd.com/read/28828354/fibrinogen-and-d-dimer-levels-in-prostate-cancer-preliminary-results
#3
Selahattin Çalışkan, Mustafa Sungur
BACKGROUND: Prostate cancer is one of the most common malignancy in men. The main risk factors for coagulation activation and thrombosis are malignancy and older age. The thrombosis risk may be associated with increased level of coagulation markers such as fibrinogen and D-dimer. The aim of this study is evaluate the relationship between coagulation markers and prostate cancer. METHODS: This prospective study includes the patients who underwent transrectal ultrasound guided prostate biopsy and prostate surgery was performed between January 2015 and January 2016...
September 2017: Prostate International
https://www.readbyqxmd.com/read/28828353/impact-of-poor-glycemic-control-of-type-2-diabetes-mellitus-on-serum-prostate-specific-antigen-concentrations-in-men
#4
Hasan Anıl Atalay, Murat Akarsu, Lutfi Canat, Volkan Ülker, İlter Alkan, Unsal Ozkuvancı
BACKGROUND: To evaluate the impact of poor glycemic control of type 2 diabetes mellitus (T2DM) on serum prostate-specific antigen (PSA) concentrations in men. METHODS: We performed a prospective analysis of 215 consecutive patients affected by erectile dysfunction (ED). ED was evaluated using the IIEF-5 questionnaire and the poor glycemic control (PGC) of T2DM was assessed according to the HbA1c criteria (International Diabetes Federation). Patients were divided into PGC group (HbA1c ≥ 7%) and control group (CG) (HbA1c < 6%)...
September 2017: Prostate International
https://www.readbyqxmd.com/read/28828352/report-of-the-second-asian-prostate-cancer-a-cap-study-meeting
#5
Choung-Soo Kim, Ji Youl Lee, Byung Ha Chung, Wun-Jae Kim, Ng Chi Fai, Lukman Hakim, Rainy Umbas, Teng Aik Ong, Jasmine Lim, Jason L Letran, Edmund Chiong, Tong-Lin Wu, Bannakij Lojanapiwat, Levent Türkeri, Declan G Murphy, Robert A Gardiner, Kim Moretti, Matthew Cooperberg, Peter Carroll, Seong Ki Mun, Shiro Hinotsu, Yoshihiko Hirao, Seiichiro Ozono, Shigeo Horie, Mizuki Onozawa, Yasuhide Kitagawa, Tadaichi Kitamura, Mikio Namiki, Hideyuki Akaza
The Asian Prostate Cancer (A-CaP) Study is an Asia-wide initiative that has been developed over the course of 2 years. The study was launched in December 2015 in Tokyo, Japan, and the participating countries and regions engaged in preparations for the study during the course of 2016, including patient registration and creation of databases for the purpose of the study. The Second A-CaP Meeting was held on September 8, 2016 in Seoul, Korea, with the participation of members and collaborators from 12 countries and regions...
September 2017: Prostate International
https://www.readbyqxmd.com/read/28828351/characteristics-and-national-trends-of-patients-receiving-treatment-of-the-primary-tumor-for-metastatic-prostate-cancer
#6
Sumi Sinha, Vinayak Muralidhar, Felix Y Feng, Paul L Nguyen
BACKGROUND: We sought to determine temporal trends in the receipt of prostatectomy or locoregional radiation to the prostate for patients with metastatic prostate cancer and to identify predictors of receipt of local treatment. METHODS: We identified 39,976 patients with metastatic prostate cancer diagnosed in 2004-2012 using the National Cancer Database (NCDB). We used logistic multivariable regression to determine trends in the receipt of prostate and/or pelvic radiation or radical prostatectomy after adjusting for demographic and clinical factors...
September 2017: Prostate International
https://www.readbyqxmd.com/read/28828350/looking-to-the-metabolic-landscapes-for-prostate-health-monitoring
#7
REVIEW
Wun-Jae Kim, Jayoung Kim
Abnormal metabolism is a widely accepted biological signature of prostatic diseases, including prostate cancer and benign prostate hyperplasia. Recently accumulated epidemiological and experimental evidence illustrate that the metabolic syndrome, impaired mitochondrial function, and prostatic pathological conditions intersect. The perturbed metabolism and metabolic mediates influence key signaling pathways in various prostatic pathological conditions. This short review article aids to highlight recent findings on metabolism, metabolic mechanisms, and mitochondrial metabolism as a possible route to finding a cure for prostate diseases, including prostate cancer...
September 2017: Prostate International
https://www.readbyqxmd.com/read/28593171/withania-somnifera-targets-interleukin-8-and-cyclooxygenase-2-in-human-prostate-cancer-progression
#8
Anand Setty Balakrishnan, Abel Arul Nathan, Mukesh Kumar, Sudhakar Ramamoorthy, Sathish Kumar Ramia Mothilal
BACKGROUND: Prostate cancer (PC) is a common noncutaneous malignancy in men. The incidence of PC is increasing at an alarming rate across the globe. Progression of PC is associated with elevated levels of interleukin-8 (IL-8) and cyclooxygenase-2 (COX-2) in malignant cells. Overexpression of these players is accompanied by chronic inflammation, increased angiogenesis, proliferation, migration, and inhibition of apoptosis. Moreover, their elevated circulating levels promote the disease progression from androgen-dependent to androgen-independent state...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28593170/increased-detrusor-collagen-is-associated-with-detrusor-overactivity-and-decreased-bladder-compliance-in-men-with-benign-prostatic-obstruction
#9
Carlos H S Bellucci, Wesley de O Ribeiro, Thiago S Hemerly, José de Bessa, Alberto A Antunes, Katia R M Leite, Homero Bruschini, Miguel Srougi, Cristiano M Gomes
BACKGROUND: This study aimed to investigate the relationship between detrusor collagen content and urodynamic parameters in men with benign prostatic obstruction. MATERIAL AND METHODS: Nineteen consecutive patients undergoing open prostatectomy for bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH) were evaluated. Urodynamic tests were performed in all patients. BOO and detrusor contractility were assessed with the BOO index (BOOI) and the bladder contractility index (BCI), respectively...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28593169/atherosclerosis-is-associated-with-erectile-function-and-lower-urinary-tract-symptoms-especially-nocturia-in-middle-aged-men
#10
Akira Tsujimura, Ippei Hiramatsu, Yusuke Aoki, Hirofumi Shimoyama, Taiki Mizuno, Taiji Nozaki, Masato Shirai, Kazuhiro Kobayashi, Yoshiaki Kumamoto, Shigeo Horie
BACKGROUND: Atherosclerosis is a systematic disease in which plaque builds up inside the arteries that can lead to serious problems related to quality of life (QOL). Lower urinary tract symptoms (LUTS), erectile dysfunction (ED), and late-onset hypogonadism (LOH) are highly prevalent in aging men and are significantly associated with a reduced QOL. However, few questionnaire-based studies have fully examined the relation between atherosclerosis and several urological symptoms. MATERIALS AND METHODS: The study comprised 303 outpatients who visited our clinic with symptoms of LOH...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28593168/prostate-specific-antigen-reduction-after-empiric-antibiotic-treatment-does-not-rule-out-biopsy-in-patients-with-lower-urinary-tract-symptoms-prospective-controlled-single-center-study
#11
Hasan Anıl Atalay, Lutfi Canat, İlter Alkan, Suleyman Sami Çakir, Fatih Altunrende
BACKGROUND: To evaluate men, with lower urinary tract symptoms and newly elevated serum prostate specific antigen (PSA) to determine whether a three-week course of ciprofloxacin antibiotics lowers serum PSA levels and affects recommendations for prostate biopsy. METHODS: A prospective, controlled, single-center prospective trial of 177 men with a newly elevated PSA and lower urinary tract symptoms was conducted. Patients were randomized to three weeks of ciprofloxacin or observation...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28593167/correlation-between-postoperative-prostate-specific-antigen-and-biochemical-recurrence-in-positive-surgical-margin-patients-single-surgeon-series
#12
Won Ik Seo, Pil Moon Kang, Jang Ho Yoon, Wansuk Kim, Jae Il Chung
BACKGROUND: To evaluate the relationship between postoperative prostate-specific antigen (PSA) levels and biochemical recurrence (BCR) after radical prostatectomy, especially in patients with positive surgical margins (PSMs). MATERIALS AND METHODS: A total of 144 patients who underwent radical prostatectomies performed by a single surgeon without any neoadjuvant or adjuvant treatment were analyzed. Differences in clinicopathological factors were compared by surgical margin status, and the relationship between postoperative PSA level and BCR in patients with PSMs was evaluated...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28593166/protective-effect-of-chuquiraga-spinosa-extract-on-n-methyl-nitrosourea-nmu-induced-prostate-cancer-in-rats
#13
Jorge Arroyo-Acevedo, Oscar Herrera-Calderón, Roberto Chávez-Asmat, Andrea Anampa-Guzmán, Víctor Chumpitaz-Cerrate, Edwin Enciso-Roca
BACKGROUND: The main objective was to evaluate the possible protective effect of Chuquiraga spinosa extract on N-methyl nitrosourea (NMU)-induced prostate cancer in rats and DU-145 cell line. MATERIALS AND METHODS: Prostate carcinogenesis was induced in 30 male Holtzman rats by providing cyproterone acetate, testosterone, and NMU. The tumors were monitored and hematological and biochemical parameters and frequency of micronucleated polychromatic erythrocytes were recorded...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28593165/minimally-invasive-surgical-therapies-for-benign-prostatic-hypertrophy-the-rise-in-minimally-invasive-surgical-therapies
#14
REVIEW
Daniel Christidis, Shannon McGrath, Marlon Perera, Todd Manning, Damien Bolton, Nathan Lawrentschuk
The prevalence of benign prostatic hypertrophy (BPH) causing bothersome lower urinary tract symptoms increases with our ageing population. Treatment of BPH traditionally begins with medical therapy and surgical intervention is then considered for those whose symptoms progress despite treatment. Minimally invasive surgical therapies have been developed as an intermediary in the treatment of BPH with the aim of decreasing the invasiveness of interventions. These therapies also aim to reduce morbidity and dysfunction related to invasive surgical procedures...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28352623/corrigendum-to-modified-urethrovesical-anastomosis-during-robot-assisted-simple-prostatectomy-technique-and-results-prostate-int-4-2016-61-64
#15
Octavio A Castillo, Ivar Vidal-Mora, Arquimedes Rodriguez-Carlin, Andres Silva, Oscar Schatloff, Vincenzo Borgna
[This corrects the article DOI: 10.1016/j.prnil.2016.04.001.].
March 2017: Prostate International
https://www.readbyqxmd.com/read/28352622/predictive-factor-of-androgen-deprivation-therapy-for-patients-with-advanced-stage-prostate-cancer
#16
Chaiyut Kongseang, Worapat Attawettayanon, Watid Kanchanawanichkul, Choosak Pripatnanont
BACKGROUND: The purpose of this study was to identify the predictive factors for the efficacy of androgen deprivation therapy (ADT) in men with hormone-sensitive prostate cancer (PC) with or without distant metastasis. METHODS: A retrospective review of PC patients was conducted of the medical records. We enrolled 246 patients who received primary ADT. PC patients treated with ADT for presumed nonlocalized PC were evaluated on the efficacy of ADT using prostate-specific antigen (PSA) time to progression (TTP) and compared factors associated with TTP in patients with distant metastasis and patients without distant metastasis...
March 2017: Prostate International
https://www.readbyqxmd.com/read/28352621/granulomatous-prostatitis-clinical-and-histomorphologic-survey-of-the-disease-in-a-tertiary-care-hospital
#17
Prakriti Shukla, Hanni V Gulwani, Sukhpreet Kaur
BACKGROUND: Granulomatous prostatitis is an uncommon entity that is diagnosed incidentally on histopathology and is broadly classified as nonspecific, specific, postsurgical (post-transurethral resection), or secondary to other rare systemic granulomatous diseases. Only very few studies are available in the literature that describe the clinical and histomorphological spectrum of the disease. METHODS: A retrospective analysis of histopathological records of 1,181 prostatic specimens received in the pathology department was done over a period of 13 years (January 2003 to January 2016)...
March 2017: Prostate International
https://www.readbyqxmd.com/read/28352620/indications-for-a-second-prostate-biopsy-in-patients-suspected-with-prostate-cancer-after-an-initial-negative-prostate-biopsy
#18
Kwang Suk Lee, Kyo Chul Koo, Kang Su Cho, Seung Hwan Lee, Woong Kyu Han, Young Deuk Choi, Sung Joon Hong, Sang Un Park, Suk Young Lee, Woo Jin Ko, Young Sig Kim, Byung Ha Chung
BACKGROUND: The present study aimed to evaluate the indications for a second prostate biopsy in patients suspected with prostate cancer after an initial negative prostate biopsy. METHODS: The present study included 421 patients who underwent repeat prostate biopsy between January 2007 and December 2015 at three hospitals. Clinicopathological data, including patient age, body mass index, history of prostate biopsy, prostate volume, prostate-specific antigen (PSA) level, PSA density, PSA velocity, and PSA fluctuation patterns, were analyzed...
March 2017: Prostate International
https://www.readbyqxmd.com/read/28352619/low-levels-of-serum-testosterone-in-middle-aged-men-impact-pathological-features-of-prostate-cancer
#19
Elton Llukani, Benjamin F Katz, Ilir Agalliu, Andrew Lightfoot, Sue-Jean S Yu, Martin Kathrins, Ziho Lee, Yu-Kai Su, Kelly Monahan Agnew, Alice McGill, Daniel D Eun, David I Lee
BACKGROUND: Serum testosterone deficiency increases with aging. Age is also a major risk factor for prostate cancer (PrCa) and PCa tumors are more frequently diagnosed among men >65 years old. We evaluated the relationship between preoperative serum testosterone and clinical/ pathological features of PrCa in middle-aged and elderly patients. METHODS: A total of 605 PrCa patients who underwent robotic-assisted radical prostatectomy between September 2010 and January 2013 at the University of Pennsylvania, and who had serum testosterone levels measured using Elecsys Testosterone II Immunoassay were included in this IRB-approved protocol...
March 2017: Prostate International
https://www.readbyqxmd.com/read/28352618/safety-and-feasibility-of-robot-assisted-radical-prostatectomy-for-clinically-localized-prostate-cancer-in-elderly-japanese-patients
#20
Masatomo Nishikawa, Hiromitsu Watanabe, Tomofumi Kurahashi
BACKGROUND: This study was conducted to assess the safety and feasibility of robot-assisted radical prostatectomy (RARP) for elderly Japanese (aged ≥ 70 years) patients with clinically localized prostate cancer (PCa). METHODS: From April 2012 to March 2016, a total of 302 consecutive patients with clinically localized PCa underwent RARP at our institute. In this series, 109 (36.1%) and 193 (63.9%) of the patients were divided into older (aged ≥ 70 years) and younger (aged <70 years) groups, respectively...
March 2017: Prostate International
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