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Prostate International

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https://www.readbyqxmd.com/read/27995116/studying-the-effect-of-type-2-diabetes-mellitus-on-prostate-related-parameters-a-prospective-single-institutional-study
#1
Ahmed Elabbady, Mohamed M Hashad, Ahmed F Kotb, Ali E Ghanem
BACKGROUND: To examine the effects of type 2 diabetes mellitus (DM) on the variables associated with prostatic growth including serum prostate-specific antigen (PSA), serum testosterone, and prostate volume, and to correlate these variables with the duration of diabetes treatment. METHODS: Our study was conducted over 3 months recruiting 501 men aged ≥ 55 years; of whom 207 had type 2 DM. Exclusion criteria were active urinary tract infection, suspicious rectal examination, urologic cancer, end-organ damage, and recent urological manipulations...
December 2016: Prostate International
https://www.readbyqxmd.com/read/27995115/impact-of-gleason-pattern-5-on-outcomes-of-patients-with-prostate-cancer-and-iodine-125-prostate-brachytherapy
#2
Tomoyuki Makino, Sotaro Miwa, Kiyoshi Koshida
BACKGROUND: The Gleason grading system is a powerful predictor of prostate cancer (PCa) prognosis. Gleason scores (GS) of 8-10 are considered as a single high-risk grade category, and Gleason Pattern 5 (GP5) predicts biochemical recurrence. We report the clinical outcomes of patients treated with (125)I prostate brachytherapy for clinically localized PCa and prognosis in the presence or absence of GP5. METHODS: We enrolled 316 patients with T1c-T2N0M0 PCa and undergoing prostate brachytherapy treatment...
December 2016: Prostate International
https://www.readbyqxmd.com/read/27995114/gleason-group-concordance-between-biopsy-and-radical-prostatectomy-specimens-a-cohort-study-from-prostate-cancer-outcome-registry-victoria
#3
Sue M Evans, Varuni Patabendi Bandarage, Caroline Kronborg, Arul Earnest, Jeremy Millar, David Clouston
BACKGROUND: A new prostate cancer (PCa) prognostic grading system [Gleason groups (GGs)] has been proposed based on the contemporary Gleason scores (GSs), which has five simplified prognostic categories. The objective of this study was to evaluate the agreement between the GGs of prostate biopsy and radical prostatectomy specimens and to identify predictive factors for upgrading GGs. METHODS: A total of 5339 cases of RP notified to the Prostate Cancer Outcomes Registry, Victoria, Australia over 6 years (2009-2014) from 46 hospitals, were included...
December 2016: Prostate International
https://www.readbyqxmd.com/read/27995113/feasibility-of-classical-secondary-hormonal-therapies-prior-to-docetaxel-therapy-in-japanese-patients-with-castration-resistant-prostate-cancer-multicenter-retrospective-study
#4
Shuya Kandori, Takayuki Yoshino, Masakazu Tsutsumi, Atsushi Yamauchi, Mikinobu Ohtani, Yoshiharu Fukuhara, Naoto Miyanaga, Jun Miyazaki, Hiroyuki Nishiyama, Toru Shimazui
BACKGROUND: We retrospectively analyzed castration-resistant prostate cancer (CRPC) patients treated with secondary hormonal therapies (SHTs) prior to docetaxel therapy. METHODS: The cases of 73 CRPC patients who underwent docetaxel therapy in 2005-2011 at four hospitals in Ibaraki, Japan were analyzed. We determined the cause-specific survival (CSS) from the start of docetaxel therapy and the time point of CRPC diagnosis, and we compared the CSS achieved with/without prior classical SHTs, which were defined as low-dose steroid and estramustine phosphate...
December 2016: Prostate International
https://www.readbyqxmd.com/read/27995112/primary-care-follow-up-of-radical-prostatectomy-patients-a-regional-new-zealand-experience
#5
Omid Yassaie, Ben McLaughlin, Marlon Perera, Todd Manning, Nathan Lawrentschuk, Andrew Malcolm
BACKGROUND: Contemporary recommendations regarding the duration of follow-up after radical prostatectomy (RP) are highly heterogeneous. Protocol-based follow-up schemes have been implemented to facilitate the expeditious identification of patients with recurrence. The aim of this study is to assess the reliability and comfort of general practitioners (GPs) in follow-up of RP. METHODS: Following institutional ethical approval, we performed a retrospective review in patients undergoing follow-up after RP between January 2004 and December 2010...
December 2016: Prostate International
https://www.readbyqxmd.com/read/27995111/prostate-cancer-biomarkers-are-we-hitting-the-mark
#6
REVIEW
Shannon McGrath, Daniel Christidis, Marlon Perera, Sung Kyu Hong, Todd Manning, Ian Vela, Nathan Lawrentschuk
PURPOSE: Localised prostate cancer diagnosis and management is increasingly complex due to its heterogeneous progression and prognostic subgroups. Pitfalls in current screening and diagnosis have prompted the search for accurate and invasive molecular and genetic biomarkers for prostate cancer. Such tools may be able to distinguish clinically significant cancers from less aggressive variants to assist with prostate cancer risk stratification and guide decisions and healthcare algorithms...
December 2016: Prostate International
https://www.readbyqxmd.com/read/27995110/prostate-cancer-screening-with-prostate-specific-antigen-a-guide-to-the-guidelines
#7
REVIEW
Sonja Cabarkapa, Marlon Perera, Shannon McGrath, Nathan Lawrentschuk
BACKGROUND: Prostate cancer remains the most common non-skin cancer malignancy in men. Prostate-specific antigen (PSA) is recognized as a biomarker for the diagnosis, monitoring, and risk prediction of prostate cancer. Its use in the setting of prostate cancer screening has been controversial due to the risk of over diagnosis and over treatment. OBJECTIVE: Within Australia, there are inconsistent recommendations surrounding the use of PSA screening in clinical practice...
December 2016: Prostate International
https://www.readbyqxmd.com/read/27689070/incidence-and-mortality-of-prostate-cancer-and-their-relationship-with-the-human-development-index-worldwide
#8
S Hassanipour-Azgomi, Abdollah Mohammadian-Hafshejani, Mahshid Ghoncheh, Farhad Towhidi, Saeid Jamehshorani, Hamid Salehiniya
BACKGROUND: The aim of this study was to evaluate the incidence and mortality of prostate cancer and their relationship with the Human Development Index (HDI) and its components in Asia in 2012. METHODS: This study was an ecological study conducted based on the GLOBOCAN project of the World Health Organization. The correlation between standardized incidence rate (SIR) and standardized mortality rate (SMR) of prostate cancer with HDI and its components was assessed using SPSS Inc Version 18...
September 2016: Prostate International
https://www.readbyqxmd.com/read/27689069/optimizing-prophylactic-antibiotic-regimen-in-patients-admitted-for%C3%A2-transrectal-ultrasound-guided-prostate-biopsies-a-prospective-randomized-study
#9
Ahmed Fahmy, Hazem Rhashad, Mohamed Mohi, Ahmed Elabbadie, Ahmed Kotb
BACKGROUND: Transrectal ultrasound-guided prostate biopsies (TRUSBx), in spite of being one of the most frequently performed urological office procedures, are associated with a spectrum of complications, most significantly including infection. The aim of the study is to evaluate the prevalence of fluoroquinolone-resistant bacteria in rectal swabs from our local population prior to TRUSBx and to identify risk factors among a patient population harboring fluoroquinolone-resistant organisms...
September 2016: Prostate International
https://www.readbyqxmd.com/read/27689068/incidental-prostate-cancer-diagnosed-at-radical-cystoprostatectomy-for-bladder-cancer-disease-specific-outcomes-and-survival
#10
Joshua B Kaelberer, Michael A O'Donnell, Darrion L Mitchell, Anthony N Snow, Sarah L Mott, John M Buatti, Mark C Smith, John M Watkins
BACKGROUND: The current standard of care for men with muscle-invasive bladder cancer is radical cystoprostatectomy (RCP). One-third of RCP specimens demonstrate incidental prostate cancer, primarily reported in small series with limited follow-up. The aim of this study is to report mature outcomes, including patterns of failure and disease-specific recurrence rates, and survival, for a large cohort of men with incidental prostate cancer at RCP performed at a tertiary referral center. METHODS: This retrospective study describes cancer control and survival rates for men who underwent RCP for bladder cancer and were found incidentally to have prostate cancer...
September 2016: Prostate International
https://www.readbyqxmd.com/read/27689067/cytoreductive-surgery-for-men-with-metastatic-prostate-cancer
#11
Nikolas Katelaris, Declan Murphy, Nathan Lawrentschuk, Athos Katelaris, Daniel Moon
BACKGROUND: Cytoreductive surgery for metastatic prostate cancer is an emerging area of interest with a potential upside that includes local control, delayed initiation of hormone therapy, and possibly improved cancer specific survival. In order for radical prostatectomy to be an effective treatment option for men in this group, the benefits must outweigh the surgical morbidity. The aim of this study was to present a case series and assess the literature feasibility of cytoreductive surgery for men with metastatic prostate cancer...
September 2016: Prostate International
https://www.readbyqxmd.com/read/27689066/prostate-based-biofluids-for-the-detection-of-prostate-cancer-a-comparative-study-of-the-diagnostic-performance-of-cell-sourced-rna-biomarkers
#12
Matthew J Roberts, Renee S Richards, Clement W K Chow, Suhail A R Doi, Horst Joachim Schirra, Marion Buck, Hemamali Samaratunga, Joanna Perry-Keene, Diane Payton, John Yaxley, Martin F Lavin, Robert A Gardiner
BACKGROUND: Prostate cancer (PCa) diagnosis requires improvement with the aid of more accurate biomarkers. Postejaculate urethral washings (PEUW) could be a physiological equivalent to urine obtained following rectal prostatic massage, the current basis for the prostate cancer antigen 3 (PCA3) test. The aim of this study was to investigate if PEUW contained prostate-based material, evidenced by the presence of prostate specific antigen (PSA), and to evaluate the diagnostic performance of PEUW-based biomarkers...
September 2016: Prostate International
https://www.readbyqxmd.com/read/27689065/asia-prostate-cancer-study-a-cap-study-launch-symposium
#13
Hideyuki Akaza, Yoshihiko Hirao, Choung-Soo Kim, Mototsugu Oya, Seiichiro Ozono, Dingwei Ye, Matthew Cooperberg, Shiro Hinotsu, Ji Youl Lee, Gang Zhu, Mikio Namiki, Shigeo Horie, Byung Ha Chung, Chung-Hsin Chen, Ng Chi Fai, Lukman Hakim, Edmund Chiong, Jason Letran, Rainy Umbas, Kazuhiro Suzuki, Kazuo Nishimura, Teng Aik Ong, Bannakij Lojanapiwat, Tong-Lin Wu, Wun-Jae Kim, Declan Murphy, Osamu Ogawa, Peter Carroll, Seiji Naito, Taiji Tsukamoto
The Asian Prostate Cancer (A-CaP) Study is an Asia-wide initiative that has been developed over the course of 2 years. The A-CaP Study is scheduled to begin in 2016, when each participating country or region will begin registration of newly diagnosed prostate cancer patients and conduct prognosis investigations. From the data gathered, common research themes will be identified, such as comparisons among Asian countries of background factors in newly diagnosed prostate cancer patients. This is the first Asia-wide study of prostate cancer and has developed from single country research efforts in this field, including in Japan and Korea...
September 2016: Prostate International
https://www.readbyqxmd.com/read/27689064/oxidative-stress-in-prostate-cancer-patients-a-systematic-review-of-case-control-studies
#14
REVIEW
Byeongsang Oh, Gemma Figtree, Daniel Costa, Thomas Eade, George Hruby, Stephanie Lim, Aymen Elfiky, Neil Martine, David Rosenthal, Stephen Clarke, Michael Back
BACKGROUND: Prostate cancer (PCa) is the most common cancer in men in Western countries. In-vitro and in-vivo studies suggest that oxidative stress (OS) and antioxidants play a key role in the pathogenesis of chronic diseases including PCa, which is promoted by the production of reactive oxygen species and impaired antioxidant defense mechanisms. This study evaluates the association between OS and men with PCa. METHODS: A literature search was carried out on Medline, PubMed, and ScienceDirect databases, as well as manual searches from inception up to August 2015 using the keywords "Oxidative stress" or "Reactive oxygen species" or "Lipid peroxidation" AND "Prostate cancer...
September 2016: Prostate International
https://www.readbyqxmd.com/read/27358847/diagnosis-and-treatment-patterns-of-male-lower-urinary-tract-symptoms-suggestive-of-benign-prostatic-hyperplasia-in-murjani-general-hospital-central-kalimantan-indonesia
#15
Robert Adrianto Raharjo
BACKGROUND: The aim of this study was to describe the diagnosis and treatment patterns of male lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) and evaluate their appropriateness in an area without an urologist and with limited resources, such as the area covered by Murjani General Hospital, Sampit, Indonesia. METHODS: This descriptive study used data collected from medical records of patients who were diagnosed with LUTS suggestive of BPH in Murjani General Hospital between September 2013 and August 2015...
June 2016: Prostate International
https://www.readbyqxmd.com/read/27358846/modified-urethrovesical-anastomosis-during-robot-assisted-simple-prostatectomy-technique-and-results
#16
Octavio Castillo, Ivar Vidal-Mora, Arquimedes Rodriguez-Carlin, Andres Silva, Oscar Schatloff
BACKGROUND: Despite significant developments in transurethral surgery for benign prostatic hyperplasia, simple prostatectomy remains an excellent option for patients with severely enlarged glands. The objective is to describe our results of robot-assisted simple prostatectomy (RASP) with a modified urethrovesical anastomosis (UVA). METHODS: From May 2011 to February 2014, RASP with UVA was performed in 34 patients by a single surgeon (O.C.) using the da Vinci S-HD surgical system...
June 2016: Prostate International
https://www.readbyqxmd.com/read/27358845/low-density-lipoprotein-receptors-play-an-important-role-in-the-inhibition-of-prostate-cancer-cell-proliferation-by-statins
#17
Yosuke Furuya, Yoshitaka Sekine, Haruo Kato, Yoshiyuki Miyazawa, Hidekazu Koike, Kazuhiro Suzuki
BACKGROUND: There are some reports about the antitumor effects of statins in these days. Statins decrease the level of cholesterol in the blood by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Inhibition of this enzyme decreases intracellular cholesterol synthesis. Thus, the expression of low-density lipoprotein receptor (LDLr) is increased to import more cholesterol from the bloodstream. In this study, we assessed the effects of statins on the proliferation of prostate cancer cells, and studied the relationship between the expression of LDLr and the effects of statins...
June 2016: Prostate International
https://www.readbyqxmd.com/read/27358844/feasibility-of-abiraterone-acetate-treatment-in-patients-with-metastatic-castration-resistant-prostate-cancer-and-atrial-fibrillation
#18
Simon Rauch, Dominic Fong, Elisa Morra, Francesca Maines, Orazio Caffo, Gilbert Spizzo
BACKGROUND: Abiraterone acetate (AA), a selective inhibitor of the CYP17 enzyme, demonstrated a significant improvement in the treatment of patients with metastatic castration-resistant prostate cancer. The risk of endocrine side effects, mainly an increased adrenal mineralocorticoid production, could limit its use in patients with atrial fibrillation. METHODS: We retrospectively reviewed the clinical records of 85 metastatic castration-resistant prostate cancer patients treated with AA at our institutions and identified six patients suffering from concomitant atrial fibrillation...
June 2016: Prostate International
https://www.readbyqxmd.com/read/27358843/holmium-laser-enucleation-of-the-prostate-followed-by-high-intensity-focused-ultrasound-treatment-for-patients-with-huge-prostate-adenoma-and-localized-prostate-cancer-5-year-follow-up
#19
Akira Horiuchi, Satoru Muto, Shigeo Horie
BACKGROUND: To evaluate the efficacy of holmium laser enucleation of the prostate (HoLEP) followed by high-intensity focused ultrasound (HIFU) for patients with huge prostate adenoma and localized prostate cancer (CaP) and compare the morbidity and efficacy results with those observed in a similar population treated only with HIFU for a follow-up period of up to 5 years. METHODS: The present retrospective study included 30 CaP patients who underwent HIFU alone and 10 patients who underwent HoLEP followed by HIFU...
June 2016: Prostate International
https://www.readbyqxmd.com/read/27358842/relationship-of-age-prostate-specific-antigen-and-prostate-volume-in-indonesian-men-with-benign-prostatic-hyperplasia
#20
Ida Bagus O W Putra, Agus R A H Hamid, Chaidir A Mochtar, Rainy Umbas
BACKGROUND: To investigate the relationship between age, prostate specific antigen (PSA), and prostate volume (PV) in Indonesian men with histologically proven benign prostatic hyperplasia. METHODS: Data were generated from our BPH database from June 1994 until December 2013. Subjects were men with a minimum age of 40 years with chief complaint of LUTS or urinary retention, diagnosed with BPH. All patients underwent TRUS-guided prostate biopsy. Patients with PSA level >10 ng/mL were excluded from the study to exclude the possibility of occult prostate cancer...
June 2016: Prostate International
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