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Lancet Respiratory Medicine

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https://www.readbyqxmd.com/read/28784580/diesel-and-petrol-cars-to-be-banned-by-2040
#1
Aaron van Dorn
No abstract text is available yet for this article.
August 4, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28784579/uk-government-announces-new-life-sciences-inquiry
#2
Kathryn Clark
No abstract text is available yet for this article.
August 4, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28781029/hospital-acquired-pneumonia-surveillance-an-unmet-need
#3
Victoria C Ewan, Miles D Witham, Martin Kiernan, A John Simpson
No abstract text is available yet for this article.
August 3, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28780183/does-inhaled-steroid-therapy-help-emerging-asthma-in-early-childhood
#4
REVIEW
Elissa M Abrams, Stanley J Szefler, Allan B Becker
Although early childhood wheeze is common, persistent asthma is less common. However, of those children who do progress to persistent asthma, lung function abnormalities and airway remodelling can already be seen early in life and can increase in magnitude with time. There has been a general expectation that early use of inhaled corticosteroid (ICS) could change the natural history of asthma if started in the young child with wheeze. Despite this expectation, the role of ICS therapy in altering the natural course of disease in children with emerging asthma is not well defined...
August 2, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28736045/comparative-effectiveness-of-high-dose-versus-standard-dose-influenza-vaccination-on-numbers-of-us-nursing-home-residents-admitted-to-hospital-a-cluster-randomised-trial
#5
Stefan Gravenstein, H Edward Davidson, Monica Taljaard, Jessica Ogarek, Pedro Gozalo, Lisa Han, Vincent Mor
BACKGROUND: Immune responses to influenza vaccines decline with age, reducing clinical effectiveness. We compared the effect of the more immunogenic high-dose trivalent influenza vaccine with a standard-dose vaccine to identify the effect on reducing hospital admissions of nursing home residents in the USA. METHODS: We did a single-blind, pragmatic, comparative effectiveness, cluster-randomised trial with a 2 × 2 factorial design. Medicare-certified nursing homes in the USA located within 50 miles of a Centers for Disease Control and Prevention influenza reporting city were recruited, so long as the facilities were not located in a hospital, had more than 50 long-stay residents, had less than 20% of the population aged under 65 years, and were not already planning to administer the high-dose influenza vaccine to residents...
July 20, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28736044/high-dose-influenza-vaccine-in-nursing-home-residents-not-to-be-sneezed-at
#6
Marc-Alain Widdowson, Joseph S Bresee
No abstract text is available yet for this article.
July 20, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28734825/trials-of-statins-in-delirium-stymied-by-complex-methods
#7
Yoanna Skrobik, John Devlin
No abstract text is available yet for this article.
July 19, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28734824/is-there-a-vanishing-pulmonary-capillary-syndrome
#8
Marius M Hoeper, Anton Vonk-Noordegraaf
No abstract text is available yet for this article.
July 19, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28734823/evaluation-of-early-administration-of-simvastatin-in-the-prevention-and-treatment-of-delirium-in-critically-ill-patients-undergoing-mechanical-ventilation-modus-a-randomised-double-blind-placebo-controlled-trial
#9
Valerie J Page, Annalisa Casarin, E Wesley Ely, Xiao Bei Zhao, Cliona McDowell, Lynn Murphy, Daniel F McAuley
BACKGROUND: Delirium in critically ill patients is associated with poor clinical outcomes. Neuroinflammation might be an important mechanism in the pathogenesis of delirium, and since simvastatin has anti-inflammatory properties it might reduce delirium. We aimed to establish whether early treatment with simvastatin would decrease the time that survivors of critical illness spent in delirium or coma. METHODS: We undertook this randomised, double-blind, placebo-controlled trial in a general adult intensive care unit (ICU) in Watford General Hospital (Watford, UK)...
July 19, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28734822/icotinib-versus-whole-brain-irradiation-in-patients-with-egfr-mutant-non-small-cell-lung-cancer-and-multiple-brain-metastases-brain-a-multicentre-phase-3-open-label-parallel-randomised-controlled-trial
#10
Jin-Ji Yang, Caicun Zhou, Yisheng Huang, Jifeng Feng, Sun Lu, Yong Song, Cheng Huang, Gang Wu, Li Zhang, Ying Cheng, Chengping Hu, Gongyan Chen, Li Zhang, Xiaoqing Liu, Hong Hong Yan, Fen Lai Tan, Wenzhao Zhong, Yi-Long Wu
BACKGROUND: For patients with non-small-cell lung cancer (NSCLC) and multiple brain metastases, whole-brain irradiation (WBI) is a standard-of-care treatment, but its effects on neurocognition are complex and concerning. We compared the efficacy of an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), icotinib, versus WBI with or without chemotherapy in a phase 3 trial of patients with EGFR-mutant NSCLC and multiple brain metastases. METHODS: We did a multicentre, open-label, parallel randomised controlled trial (BRAIN) at 17 hospitals in China...
July 19, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28734821/deep-learning-poised-to-revolutionise-diagnostic-imaging
#11
Bryant Furlow
No abstract text is available yet for this article.
July 19, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28734820/brain-metastases-in-patients-with-egfr-mutant-non-small-cell-lung-cancer
#12
Rafael Rosell, Niki Karachaliou
No abstract text is available yet for this article.
July 19, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28705688/treatment-limitations-in-the-era-of-ecmo
#13
Daniel Brodie, J Randall Curtis, Jean-Louis Vincent, Jan Bakker, Crystal E Brown, Jacques Creteur, Laurent Papazian, Robert N Sladen, V Marco Ranieri
No abstract text is available yet for this article.
July 10, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28693987/a-pragmatic-approach-to-simplify-inhaler-therapy-for-copd
#14
Brian Lipworth, Sunny Jabbal
No abstract text is available yet for this article.
July 7, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28666610/spanish-flu-the-first-horseman
#15
Talha Khan Burki
No abstract text is available yet for this article.
June 27, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28666608/strict-adherence-rules-to-obtain-monoclonal-therapy-might-cost-lives
#16
Ruth H Green, Dominick Shaw
No abstract text is available yet for this article.
June 27, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28624389/plasma-proteome-analysis-in-patients-with-pulmonary-arterial-hypertension-an-observational-cohort-study
#17
Christopher J Rhodes, John Wharton, Pavandeep Ghataorhe, Geoffrey Watson, Barbara Girerd, Luke S Howard, J Simon R Gibbs, Robin Condliffe, Charles A Elliot, David G Kiely, Gerald Simonneau, David Montani, Olivier Sitbon, Henning Gall, Ralph T Schermuly, H Ardeschir Ghofrani, Allan Lawrie, Marc Humbert, Martin R Wilkins
BACKGROUND: Idiopathic and heritable pulmonary arterial hypertension form a rare but molecularly heterogeneous disease group. We aimed to measure and validate differences in plasma concentrations of proteins that are associated with survival in patients with idiopathic or heritable pulmonary arterial hypertension to improve risk stratification. METHODS: In this observational cohort study, we enrolled patients with idiopathic or heritable pulmonary arterial hypertension from London (UK; cohorts 1 and 2), Giessen (Germany; cohort 3), and Paris (France; cohort 4)...
June 14, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28624387/aptamer-based-proteomic-profiling-for-prognostication-in-pulmonary-arterial-hypertension
#18
Evangelos Giannitsis, Matthias Mueller-Hennessen, Hugo A Katus
No abstract text is available yet for this article.
June 14, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28606620/efficacy-and-safety-of-lumacaftor-and-ivacaftor-in-patients-aged-6-11-years-with-cystic-fibrosis-homozygous-for-f508del-cftr-a-randomised-placebo-controlled-phase-3-trial
#19
Felix Ratjen, Christopher Hug, Gautham Marigowda, Simon Tian, Xiaohong Huang, Sanja Stanojevic, Carlos E Milla, Paul D Robinson, David Waltz, Jane C Davies
BACKGROUND: Lumacaftor and ivacaftor combination treatment showed efficacy in patients aged 12 years or older with cystic fibrosis homozygous for F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in placebo-controlled studies and patients aged 6-11 years with cystic fibrosis homozygous for F508del-CFTR in an open-label study. We report efficacy and safety of lumacaftor and ivacaftor in patients with cystic fibrosis aged 6-11 years homozygous for F508del-CFTR. METHODS: In this phase 3, randomised, double-blind, placebo-controlled, multicentre study, patients were enrolled at 54 hospitals and medical centres in nine countries (the USA, Australia, Belgium, Canada, Denmark, France, Germany, Sweden, and the UK)...
June 8, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28601554/eosinophils-in-copd-just-another-biomarker
#20
REVIEW
Mona Bafadhel, Ian D Pavord, Richard E K Russell
Eosinophils are innate immune cells that, under certain conditions, can be recruited to the lungs, where they have an incompletely understood role in health and disease. Eosinophils have been found in the airways, tissues, and circulation of patients with COPD, during both stable disease and exacerbations. Epidemiological studies and post-hoc analyses of clinical trials of corticosteroid treatment for COPD have shown that the blood eosinophil count is associated with the risk of COPD exacerbations, mortality, decline in FEV1, and response to both inhaled and systemic corticosteroids...
June 7, 2017: Lancet Respiratory Medicine
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