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Lancet Respiratory Medicine

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https://www.readbyqxmd.com/read/30642778/ecmo-for-ards-from-salvage-to-standard-of-care
#1
Darryl Abrams, Niall D Ferguson, Laurent Brochard, Eddy Fan, Alain Mercat, Alain Combes, Vin Pellegrino, Matthieu Schmidt, Arthur S Slutsky, Daniel Brodie
No abstract text is available yet for this article.
January 11, 2019: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30642777/ecmo-in-severe-acute-respiratory-distress-syndrome
#2
Michael A Matthay
No abstract text is available yet for this article.
January 11, 2019: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30642776/venovenous-extracorporeal-membrane-oxygenation-for-acute-respiratory-distress-syndrome-a-systematic-review-and-meta-analysis
#3
Laveena Munshi, Allan Walkey, Ewan Goligher, Tai Pham, Elizabeth M Uleryk, Eddy Fan
BACKGROUND: Use of extracorporeal membrane oxygenation (ECMO) in adults with severe acute respiratory distress syndrome has increased in the past 10 years. However, the efficacy of venovenous ECMO in people with acute respiratory distress syndrome is uncertain according to the most recent data. We aimed to estimate the effect of venovenous ECMO on mortality from acute respiratory distress syndrome. METHODS: In this systematic review and meta-analysis, we searched MEDLINE (including MEDLINE In-Process and Epub Ahead of Print), Embase and the Wiley search platform in the Cochrane database for randomised controlled trials and observational studies with matching of conventional mechanical ventilation with and without venovenous ECMO in adults with acute respiratory distress syndrome...
January 11, 2019: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30638907/the-innovations-cleaning-our-air
#4
Talha Khan Burki
No abstract text is available yet for this article.
January 9, 2019: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30630779/delamanid-does-it-have-a-role-in-tuberculosis-treatment
#5
Rosella Centis, Giovanni Sotgiu, Giovanni Battista Migliori
No abstract text is available yet for this article.
January 7, 2019: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30630778/efficacy-and-safety-of-delamanid-in-combination-with-an-optimised-background-regimen-for-treatment-of-multidrug-resistant-tuberculosis-a-multicentre-randomised-double-blind-placebo-controlled-parallel-group-phase-3-trial
#6
Florian von Groote-Bidlingmaier, Ramonde Patientia, Epifanio Sanchez, Vincent Balanag, Eduardo Ticona, Patricia Segura, Elizabeth Cadena, Charles Yu, Andra Cirule, Victor Lizarbe, Edita Davidaviciene, Liliana Domente, Ebrahim Variava, Janice Caoili, Manfrid Danilovits, Virgaine Bielskiene, Suzanne Staples, Norbert Hittel, Carolyn Petersen, Charles Wells, Jeffrey Hafkin, Lawrence J Geiter, Rajesh Gupta
BACKGROUND: Delamanid is one of two recently approved drugs for the treatment of multidrug-resistant tuberculosis. We aimed to evaluate the safety and efficacy of delamanid in the first 6 months of treatment. METHODS: This randomised, double-blind, placebo-controlled, phase 3 trial was done at 17 sites in seven countries (Estonia, Latvia, Lithuania, Moldova, Peru, the Philippines, and South Africa). We enrolled eligible adults (>18 years) with pulmonary multidrug-resistant tuberculosis to receive, in combination with an optimised background regimen developed according to WHO and national guidelines, either oral delamanid (100 mg twice daily) for 2 months followed by 200 mg once daily for 4 months or placebo (same regimen)...
January 7, 2019: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30584055/dna-methylation-signatures-of-atopy-and-asthma
#7
Ivana V Yang
No abstract text is available yet for this article.
December 21, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30584054/dna-methylation-in-nasal-epithelium-atopy-and-atopic-asthma-in-children-a-genome-wide-study
#8
Erick Forno, Ting Wang, Cancan Qi, Qi Yan, Cheng-Jian Xu, Nadia Boutaoui, Yueh-Ying Han, Daniel E Weeks, Yale Jiang, Franziska Rosser, Judith M Vonk, Sharon Brouwer, Edna Acosta-Perez, Angel Colón-Semidey, María Alvarez, Glorisa Canino, Gerard H Koppelman, Wei Chen, Juan C Celedón
BACKGROUND: Epigenetic mechanisms could alter the airway epithelial barrier and ultimately lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that are associated with-and could accurately classify-atopy and atopic asthma in school-aged children. METHODS: We did a genome-wide study of DNA methylation in nasal epithelium and atopy or atopic asthma in 483 Puerto Rican children aged 9-20 years, recruited using multistage probability sampling...
December 21, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30553848/mortality-morbidity-and-hospitalisations-due-to-influenza-lower-respiratory-tract-infections-2017-an-analysis-for-the-global-burden-of-disease-study-2017
#9
(no author information available yet)
BACKGROUND: Although the burden of influenza is often discussed in the context of historical pandemics and the threat of future pandemics, every year a substantial burden of lower respiratory tract infections (LRTIs) and other respiratory conditions (like chronic obstructive pulmonary disease) are attributable to seasonal influenza. The Global Burden of Disease Study (GBD) 2017 is a systematic scientific effort to quantify the health loss associated with a comprehensive set of diseases and disabilities...
December 12, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30553847/calling-time-on-asthma-deaths-in-tropical-regions-how-much-longer-must-people-wait-for-essential-medicines
#10
Innes Asher, Karen Bissell, Chen-Yuan Chiang, Asma El Sony, Philippa Ellwood, Luis García-Marcos, Guy B Marks, Kevin Mortimer, Neil Pearce, David Strachan
No abstract text is available yet for this article.
December 12, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30553846/reconciling-estimates-of-the-global-influenza-burden
#11
Sheena G Sullivan, Benjamin J Cowling
No abstract text is available yet for this article.
December 12, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30553845/our-planet-or-our-patients-is-the-sky-the-limit-for-inhaler-choice
#12
Omar S Usmani, Jane Scullion, Duncan Keeley
No abstract text is available yet for this article.
December 12, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30552067/moderate-to-severe-asthma-in-individuals-of-european-ancestry-a-genome-wide-association-study
#13
Nick Shrine, Michael A Portelli, Catherine John, María Soler Artigas, Neil Bennett, Robert Hall, Jon Lewis, Amanda P Henry, Charlotte K Billington, Azaz Ahmad, Richard J Packer, Dominick Shaw, Zara E K Pogson, Andrew Fogarty, Tricia M McKeever, Amisha Singapuri, Liam G Heaney, Adel H Mansur, Rekha Chaudhuri, Neil C Thomson, John W Holloway, Gabrielle A Lockett, Peter H Howarth, Ratko Djukanovic, Jenny Hankinson, Robert Niven, Angela Simpson, Kian Fan Chung, Peter J Sterk, John D Blakey, Ian M Adcock, Sile Hu, Yike Guo, Maen Obeidat, Don D Sin, Maarten van den Berge, David C Nickle, Yohan Bossé, Martin D Tobin, Ian P Hall, Christopher E Brightling, Louise V Wain, Ian Sayers
BACKGROUND: Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribute to moderate-to-severe asthma, and provide novel mechanistic insights using expression analyses in patients with asthma. METHODS: In this genome-wide association study, we used a two-stage case-control design. In stage 1, we genotyped patient-level data from two UK cohorts (the Genetics of Asthma Severity and Phenotypes [GASP] initiative and the Unbiased BIOmarkers in PREDiction of respiratory disease outcomes [U-BIOPRED] project) and used data from the UK Biobank to collect patient-level genomic data for cases and controls of European ancestry in a 1:5 ratio...
December 11, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30552066/genetic-insights-into-moderate-to-severe-asthma
#14
Rachel Nadif
No abstract text is available yet for this article.
December 11, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30545610/nhs-staff-shortages-threaten-the-future-of-respiratory-health
#15
EDITORIAL
The Lancet Respiratory Medicine
No abstract text is available yet for this article.
December 10, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30529232/acute-respiratory-failure-in-immunocompromised-adults
#16
REVIEW
Elie Azoulay, Djamel Mokart, Achille Kouatchet, Alexandre Demoule, Virginie Lemiale
Acute respiratory failure occurs in up to half of patients with haematological malignancies and 15% of those with solid tumours or solid organ transplantation. Mortality remains high. Factors associated with mortality include a need for invasive mechanical ventilation, organ dysfunction, older age, frailty or poor performance status, delayed intensive care unit admission, and acute respiratory failure due to an invasive fungal infection or unknown cause. In addition to appropriate antibacterial therapy, initial clinical management aims to restore oxygenation and predict the most probable cause based on variables related to the underlying disease, acute respiratory failure characteristics, and radiographic findings...
December 7, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30527956/genetic-determinants-of-risk-in-pulmonary-arterial-hypertension-international-genome-wide-association-studies-and-meta-analysis
#17
Christopher J Rhodes, Ken Batai, Marta Bleda, Matthias Haimel, Laura Southgate, Marine Germain, Michael W Pauciulo, Charaka Hadinnapola, Jurjan Aman, Barbara Girerd, Amit Arora, Jo Knight, Ken B Hanscombe, Jason H Karnes, Marika Kaakinen, Henning Gall, Anna Ulrich, Lars Harbaum, Inês Cebola, Jorge Ferrer, Katie Lutz, Emilia M Swietlik, Ferhaan Ahmad, Philippe Amouyel, Stephen L Archer, Rahul Argula, Eric D Austin, David Badesch, Sahil Bakshi, Christopher Barnett, Raymond Benza, Nitin Bhatt, Harm J Bogaard, Charles D Burger, Murali Chakinala, Colin Church, John G Coghlan, Robin Condliffe, Paul A Corris, Cesare Danesino, Stéphanie Debette, C Gregory Elliott, Jean Elwing, Melanie Eyries, Terry Fortin, Andre Franke, Robert P Frantz, Adaani Frost, Joe G N Garcia, Stefano Ghio, Hossein-Ardeschir Ghofrani, J Simon R Gibbs, John Harley, Hua He, Nicholas S Hill, Russel Hirsch, Arjan C Houweling, Luke S Howard, Dunbar Ivy, David G Kiely, James Klinger, Gabor Kovacs, Tim Lahm, Matthias Laudes, Rajiv D Machado, Robert V MacKenzie Ross, Keith Marsolo, Lisa J Martin, Shahin Moledina, David Montani, Steven D Nathan, Michael Newnham, Andrea Olschewski, Horst Olschewski, Ronald J Oudiz, Willem H Ouwehand, Andrew J Peacock, Joanna Pepke-Zaba, Zia Rehman, Ivan Robbins, Dan M Roden, Erika B Rosenzweig, Ghulam Saydain, Laura Scelsi, Robert Schilz, Werner Seeger, Christian M Shaffer, Robert W Simms, Marc Simon, Olivier Sitbon, Jay Suntharalingam, Haiyang Tang, Alexander Y Tchourbanov, Thenappan Thenappan, Fernando Torres, Mark R Toshner, Carmen M Treacy, Anton Vonk Noordegraaf, Quinten Waisfisz, Anna K Walsworth, Robert E Walter, John Wharton, R James White, Jeffrey Wilt, Stephen J Wort, Delphine Yung, Allan Lawrie, Marc Humbert, Florent Soubrier, David-Alexandre Trégouët, Inga Prokopenko, Richard Kittles, Stefan Gräf, William C Nichols, Richard C Trembath, Ankit A Desai, Nicholas W Morrell, Martin R Wilkins
BACKGROUND: Rare genetic variants cause pulmonary arterial hypertension, but the contribution of common genetic variation to disease risk and natural history is poorly characterised. We tested for genome-wide association for pulmonary arterial hypertension in large international cohorts and assessed the contribution of associated regions to outcomes. METHODS: We did two separate genome-wide association studies (GWAS) and a meta-analysis of pulmonary arterial hypertension...
December 5, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30527955/common-genetic-variants-in-pulmonary-arterial-hypertension
#18
Sue Gu, Rahul Kumar, Michael H Lee, Claudia Mickael, Brian B Graham
No abstract text is available yet for this article.
December 5, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30503311/pandemics-past-present-and-future
#19
Talha Khan Burki
No abstract text is available yet for this article.
November 29, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30477764/subcutaneous-treprostinil-a-new-treatment-for-chronic-thromboembolic-pulmonary-hypertension
#20
Hossein-Ardeschir Ghofrani
No abstract text is available yet for this article.
November 23, 2018: Lancet Respiratory Medicine
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