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Lancet Respiratory Medicine

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https://www.readbyqxmd.com/read/30220492/the-long-wait-for-lungs
#1
EDITORIAL
The Lancet Respiratory Medicine
No abstract text is available yet for this article.
September 13, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30219243/sharp-rise-in-sepsis-deaths-in-the-uk
#2
Talha Khan Burki
No abstract text is available yet for this article.
September 12, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30170904/effect-of-ambulatory-oxygen-on-quality-of-life-for-patients-with-fibrotic-lung-disease-ambox-a-prospective-open-label-mixed-method-crossover-randomised-controlled-trial
#3
Dina Visca, Letizia Mori, Vicky Tsipouri, Sharon Fleming, Ashi Firouzi, Matteo Bonini, Matthew J Pavitt, Veronica Alfieri, Sara Canu, Martina Bonifazi, Cristina Boccabella, Angelo De Lauretis, Carmel J W Stock, Peter Saunders, Andrew Montgomery, Charlotte Hogben, Anna Stockford, Margaux Pittet, Jo Brown, Felix Chua, Peter M George, Philip L Molyneaux, Georgios A Margaritopoulos, Maria Kokosi, Vasileios Kouranos, Anne Marie Russell, Surinder S Birring, Alfredo Chetta, Toby M Maher, Paul Cullinan, Nicholas S Hopkinson, Winston Banya, Jennifer A Whitty, Huzaifa Adamali, Lisa G Spencer, Morag Farquhar, Piersante Sestini, Athol U Wells, Elisabetta A Renzoni
BACKGROUND: In fibrotic interstitial lung diseases, exertional breathlessness is strongly linked to health-related quality of life (HRQOL). Breathlessness is often associated with oxygen desaturation, but few data about the use of ambulatory oxygen in patients with fibrotic interstitial lung disease are available. We aimed to assess the effects of ambulatory oxygen on HRQOL in patients with interstitial lung disease with isolated exertional hypoxia. METHODS: AmbOx was a prospective, open-label, mixed-method, crossover randomised controlled clinical trial done at three centres for interstitial lung disease in the UK...
August 28, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30170903/ambulatory-oxygen-and-quality-of-life-in-interstitial-lung-disease
#4
David B Page, Victor J Thannickal
No abstract text is available yet for this article.
August 28, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30150014/erlotinib-versus-vinorelbine-plus-cisplatin-as-adjuvant-therapy-in-chinese-patients-with-stage-iiia-egfr-mutation-positive-non-small-cell-lung-cancer-evan-a-randomised-open-label-phase-2-trial
#5
Dongsheng Yue, Shidong Xu, Qun Wang, Xiaofei Li, Yi Shen, Heng Zhao, Chun Chen, Weimin Mao, Wei Liu, Junfeng Liu, Lanjun Zhang, Haitao Ma, Qiang Li, Yue Yang, Yongyu Liu, Haiquan Chen, Changli Wang
BACKGROUND: Adjuvant chemotherapy after radical resection of stage IIIA non-small-cell lung cancer (NSCLC) has quite poor outcomes. We aimed to investigate whether adjuvant erlotinib therapy improves 2-year disease-free survival compared with chemotherapy in epidermal growth factor receptor (EGFR) mutation-positive stage IIIA NSCLC. METHODS: In this randomised, open-label, phase 2 trial, eligible patients aged 18-75 years who had undergone complete (R0) resection of histologically or pathologically confirmed stage IIIA EGFR mutation-positive NSCLC and had not received any previous anticancer therapies were enrolled...
August 24, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30150013/erlotinib-as-adjuvant-therapy-in-egfr-mutant-nsclc
#6
Jacek Jassem
No abstract text is available yet for this article.
August 24, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30150012/sepsis-care-bundles-a-work-in-progress
#7
Judith A Gilbert
No abstract text is available yet for this article.
August 24, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30143445/taking-cystic-fibrosis-to-the-stage
#8
Peter Ranscombe
No abstract text is available yet for this article.
August 21, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30104169/changing-the-treatment-landscape-for-latent-tuberculosis-with-rifampicin
#9
Priya Venkatesan
No abstract text is available yet for this article.
August 10, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30100403/epigenetic-prediction-of-response-to-anti-pd-1-treatment-in-non-small-cell-lung-cancer-a-multicentre-retrospective-analysis
#10
Michäel Duruisseaux, Anna Martínez-Cardús, Maria E Calleja-Cervantes, Sebastian Moran, Manuel Castro de Moura, Veronica Davalos, David Piñeyro, Montse Sanchez-Cespedes, Nicolas Girard, Marie Brevet, Etienne Giroux-Leprieur, Coraline Dumenil, Monica Pradotto, Paolo Bironzo, Enrica Capelletto, Silvia Novello, Alexis Cortot, Marie-Christine Copin, Niki Karachaliou, Maria Gonzalez-Cao, Sergio Peralta, Luis M Montuenga, Ignacio Gil-Bazo, Iosune Baraibar, Maria D Lozano, Mar Varela, Jose C Ruffinelli, Ramon Palmero, Ernest Nadal, Teresa Moran, Lidia Perez, Immaculada Ramos, Qingyang Xiao, Agustin F Fernandez, Mario F Fraga, Marta Gut, Ivo Gut, Cristina Teixidó, Noelia Vilariño, Aleix Prat, Noemi Reguart, Amparo Benito, Pilar Garrido, Isabel Barragan, Jean-François Emile, Rafael Rosell, Elisabeth Brambilla, Manel Esteller
BACKGROUND: Anti-programmed death-1 (PD-1) treatment for advanced non-small-cell lung cancer (NSCLC) has improved the survival of patients. However, a substantial percentage of patients do not respond to this treatment. We examined the use of DNA methylation profiles to determine the efficacy of anti-PD-1 treatment in patients recruited with current stage IV NSCLC. METHODS: In this multicentre study, we recruited adult patients from 15 hospitals in France, Spain, and Italy who had histologically proven stage IV NSCLC and had been exposed to PD-1 blockade during the course of the disease...
August 9, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30076121/can-antibiotic-resistance-be-reduced-by-vaccinating-against-respiratory-disease
#11
Katherine E Atkins, Marc Lipsitch
No abstract text is available yet for this article.
July 31, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30076120/let-s-add-invasive-aspergillosis-to-the-list-of-influenza-complications
#12
Frederic Lamoth, Thierry Calandra
No abstract text is available yet for this article.
July 31, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30076119/invasive-aspergillosis-in-patients-admitted-to-the-intensive-care-unit-with-severe-influenza-a-retrospective-cohort-study
#13
Alexander F A D Schauwvlieghe, Bart J A Rijnders, Nele Philips, Rosanne Verwijs, Lore Vanderbeke, Carla Van Tienen, Katrien Lagrou, Paul E Verweij, Frank L Van de Veerdonk, Diederik Gommers, Peter Spronk, Dennis C J J Bergmans, Astrid Hoedemaekers, Eleni-Rosalina Andrinopoulou, Charlotte H S B van den Berg, Nicole P Juffermans, Casper J Hodiamont, Alieke G Vonk, Pieter Depuydt, Jerina Boelens, Joost Wauters
BACKGROUND: Invasive pulmonary aspergillosis typically occurs in an immunocompromised host. For almost a century, influenza has been known to set up for bacterial superinfections, but recently patients with severe influenza were also reported to develop invasive pulmonary aspergillosis. We aimed to measure the incidence of invasive pulmonary aspergillosis over several seasons in patients with influenza pneumonia in the intensive care unit (ICU) and to assess whether influenza was an independent risk factor for invasive pulmonary aspergillosis...
July 31, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30037714/six-lobe-bronchoalveolar-lavage-in-children-with-cystic-fibrosis
#14
LETTER
Barry Linnane, Paul McNally
No abstract text is available yet for this article.
July 20, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30037712/six-lobe-bronchoalveolar-lavage-in-children-with-cystic-fibrosis-authors-reply
#15
LETTER
Julian T Forton, Iolo Doull, Lena P Thia
No abstract text is available yet for this article.
July 20, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30029969/corrections
#16
(no author information available yet)
No abstract text is available yet for this article.
July 17, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30006071/the-role-of-glucocorticoids-as-adjunctive-treatment-for-sepsis-in-the-modern-era
#17
Paul E Marik
Glucocorticoids have been used as adjunctive therapy in patients with sepsis and septic shock for more than four decades. The rationale for the use of glucocorticoids is that this class of drugs downregulates the proinflammatory response and limits the anti-inflammatory response while preserving innate immunity. Between 1976 and 2017, 22 randomised placebo-controlled trials have been published evaluating the benefit of glucocorticoids in patients with community-acquired pneumonia, sepsis, and septic shock. These studies produced conflicting results...
July 10, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30001996/tropism-replication-competence-and-innate-immune-responses-of-influenza-virus-an-analysis-of-human-airway-organoids-and-ex-vivo-bronchus-cultures
#18
Kenrie P Y Hui, Rachel H H Ching, Stan K H Chan, John M Nicholls, Norman Sachs, Hans Clevers, J S Malik Peiris, Michael C W Chan
BACKGROUND: Human airway organoids are three-dimensional cultures derived from stem cells, which self-organise in ex-vivo conditions to form so-called mini-airways. The cellular morphology of these cultures is physiologically similar to the human airway, with cilia, goblet cells, and club cells facing the inner lumen and basal cells situated at the outer layer. The aim of this study was to compare replication competence, tissue tropism, and host responses elicited by human and avian strains of influenza A virus in ex-vivo human bronchus and human airway organoids...
July 9, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30001993/cell-culture-keeps-pace-with-influenza-virus
#19
Jessica A Belser
No abstract text is available yet for this article.
July 9, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29954691/black-lung-is-still-a-threat
#20
Jules Morgan
No abstract text is available yet for this article.
June 26, 2018: Lancet Respiratory Medicine
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