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Lancet Respiratory Medicine

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https://www.readbyqxmd.com/read/28438502/us-drug-shortages-might-have-led-to-more-patient-deaths
#1
Bryant Furlow
No abstract text is available yet for this article.
April 21, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28438501/fatigue-in-copd-an-important-yet-ignored-symptom
#2
Martijn A Spruit, Jan H Vercoulen, Mirjam A G Sprangers, Emiel F M Wouters
No abstract text is available yet for this article.
April 21, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28412184/clinical-trial-research-in-focus-why-do-so-many-clinical-trials-fail-in-ipf
#3
Paolo Spagnolo, Toby M Maher
No abstract text is available yet for this article.
April 12, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28410947/marching-for-science
#4
Aaron van Dorn
No abstract text is available yet for this article.
April 11, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28408245/combined-bevacizumab-and-erlotinib-treatment-in-patients-with-lung-cancer-with-the-t790m-resistance-mutation
#5
Tetsuya Mitsudomi
No abstract text is available yet for this article.
April 10, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28408244/us-pollution-policy-up-in-the-air
#6
EDITORIAL
The Lancet Respiratory Medicine
No abstract text is available yet for this article.
April 10, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28408243/erlotinib-and-bevacizumab-in-patients-with-advanced-non-small-cell-lung-cancer-and-activating-egfr-mutations-belief-an-international-multicentre-single-arm-phase-2-trial
#7
Rafael Rosell, Urania Dafni, Enriqueta Felip, Alessandra Curioni-Fontecedro, Oliver Gautschi, Solange Peters, Bartomeu Massutí, Ramon Palmero, Santiago Ponce Aix, Enric Carcereny, Martin Früh, Miklos Pless, Sanjay Popat, Athanasios Kotsakis, Sinead Cuffe, Paolo Bidoli, Adolfo Favaretto, Patrizia Froesch, Noemí Reguart, Javier Puente, Linda Coate, Fabrice Barlesi, Daniel Rauch, Michael Thomas, Carlos Camps, Jose Gómez-Codina, Margarita Majem, Rut Porta, Riyaz Shah, Emer Hanrahan, Roswitha Kammler, Barbara Ruepp, Manuela Rabaglio, Marie Kassapian, Niki Karachaliou, Rachel Tam, David S Shames, Miguel A Molina-Vila, Rolf A Stahel
BACKGROUND: The tyrosine kinase inhibitor erlotinib improves the outcomes of patients with advanced non-small-cell lung carcinoma (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutations. The coexistence of the T790M resistance mutation with another EGFR mutation in treatment-naive patients has been associated with a shorter progression-free survival to EGFR inhibition than in the absence of the T790M mutation. To test this hypothesis clinically, we developed a proof-of-concept study, in which patients with EGFR-mutant NSCLC were treated with the combination of erlotinib and bevacizumab, stratified by the presence of the pretreatment T790M mutation...
April 10, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28392237/routine-molecular-point-of-care-testing-for-respiratory-viruses-in-adults-presenting-to-hospital-with-acute-respiratory-illness-respoc-a-pragmatic-open-label-randomised-controlled-trial
#8
Nathan J Brendish, Ahalya K Malachira, Lawrence Armstrong, Rebecca Houghton, Sandra Aitken, Esther Nyimbili, Sean Ewings, Patrick J Lillie, Tristan W Clark
BACKGROUND: Respiratory virus infection is a common cause of hospitalisation in adults. Rapid point-of-care testing (POCT) for respiratory viruses might improve clinical care by reducing unnecessary antibiotic use, shortening length of hospital stay, improving influenza detection and treatment, and rationalising isolation facility use; however, insufficient evidence exists to support its use over standard clinical care. We aimed to assess the effect of routine POCT on a broad range of clinical outcomes including antibiotic use...
April 6, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28392236/reducing-diagnostic-uncertainty-to-improve-treatment-of-respiratory-infections
#9
Andrew T Pavia
No abstract text is available yet for this article.
April 6, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28392235/corrections
#10
(no author information available yet)
No abstract text is available yet for this article.
April 6, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28395936/efficacy-of-mepolizumab-add-on-therapy-on-health-related-quality-of-life-and-markers-of-asthma-control-in-severe-eosinophilic-asthma-musca-a-randomised-double-blind-placebo-controlled-parallel-group-multicentre-phase-3b-trial
#11
Geoffrey L Chupp, Eric S Bradford, Frank C Albers, Daniel J Bratton, Jie Wang-Jairaj, Linda M Nelsen, Jennifer L Trevor, Antoine Magnan, Anneke Ten Brinke
BACKGROUND: Mepolizumab, an anti-interleukin-5 monoclonal antibody approved as add-on therapy to standard of care for patients with severe eosinophilic asthma, has been shown in previous studies to reduce exacerbations and dependency on oral corticosteroids compared with placebo. We aimed to further assess mepolizumab in patients with severe eosinophilic asthma by examining its effect on health-related quality of life (HRQOL). METHODS: We did a randomised, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial (MUSCA) in 146 hospitals or research centres in 19 countries worldwide...
April 5, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28395935/mepolizumab-quality-of-life-and-severe-eosinophilic-asthma
#12
Ian D Pavord
No abstract text is available yet for this article.
April 5, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28395934/economic-effects-and-long-term-prospects-for-spain-s-respiratory-health
#13
Talha Khan Burki
No abstract text is available yet for this article.
April 5, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28389226/underdiagnosis-in-copd-a-battle-worth-fighting
#14
Pere Almagro, Joan B Soriano
No abstract text is available yet for this article.
April 4, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28389225/prognosis-of-asymptomatic-and-symptomatic-undiagnosed-copd-in-the-general-population-in-denmark-a-prospective-cohort-study
#15
Yunus Çolak, Shoaib Afzal, Børge G Nordestgaard, Jørgen Vestbo, Peter Lange
BACKGROUND: COPD can be diagnosed early using spirometry, but spirometry use is only recommended in symptomatic smokers, even though early stages of COPD can be asymptomatic. We investigated the prognosis of individuals with asymptomatic and symptomatic, undiagnosed COPD in the general population in Denmark. METHODS: In this prospective cohort study, we analysed data from 95 288 individuals aged 20-100 years from the Copenhagen General Population Study. 32 518 (34%) of these individuals were regarded as being at high risk for COPD (defined as individuals aged 40 years or older, with cumulative tobacco consumption of ten pack-years or higher, and without self-reported or a previous hospital contact for asthma)...
April 4, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28385476/can-india-lead-the-way-with-the-development-of-safer-cookstoves
#16
Bryant Furlow
No abstract text is available yet for this article.
April 3, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28385475/plans-to-reduce-the-high-asthma-burden-in-detroit
#17
Roxanne Nelson
No abstract text is available yet for this article.
April 3, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28365371/trump-administration-budget-proposals-bad-for-health-science-environment-and-america
#18
Bryant Furlow
No abstract text is available yet for this article.
March 29, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28363726/time-for-a-paradigm-shift-in-paediatric-anaesthesia-in-europe
#19
Jerrold Lerman
No abstract text is available yet for this article.
March 28, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28363725/incidence-of-severe-critical-events-in-paediatric-anaesthesia-apricot-a-prospective-multicentre-observational-study-in-261-hospitals-in-europe
#20
Walid Habre, Nicola Disma, Katalin Virag, Karin Becke, Tom G Hansen, Martin Jöhr, Brigitte Leva, Neil S Morton, Petronella M Vermeulen, Marzena Zielinska, Krisztina Boda, Francis Veyckemans
BACKGROUND: Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. METHODS: The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures...
March 28, 2017: Lancet Respiratory Medicine
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