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Lancet Respiratory Medicine

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https://www.readbyqxmd.com/read/29331313/predictors-of-exacerbation-risk-and-response-to-budesonide-in-patients-with-chronic-obstructive-pulmonary-disease-a-post-hoc-analysis-of-three-randomised-trials
#1
Mona Bafadhel, Stefan Peterson, Miguel A De Blas, Peter M Calverley, Stephen I Rennard, Kai Richter, Malin Fagerås
BACKGROUND: The peripheral blood eosinophil count might help identify those patients with chronic obstructive pulmonary disease (COPD) who will experience fewer exacerbations when taking inhaled corticosteroids (ICS). Previous post-hoc analyses have proposed eosinophil cutoffs that are both arbitrary and limited in evaluating complex interactions of treatment response. We modelled eosinophil count as a continuous variable to determine the characteristics that determine both exacerbation risk and clinical response to ICS in patients with COPD...
January 10, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29331312/brighter-than-gold
#2
Joan B Soriano
No abstract text is available yet for this article.
January 10, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29331311/prediction-of-mortality-in-patients-with-chronic-obstructive-pulmonary-disease-with-the-new-global-initiative-for-chronic-obstructive-lung-disease-2017-classification-a-cohort-study
#3
Anne Gedebjerg, Szimonetta Komjáthiné Szépligeti, Laura-Maria Holm Wackerhausen, Erzsébet Horváth-Puhó, Ronald Dahl, Jens Georg Hansen, Henrik Toft Sørensen, Mette Nørgaard, Peter Lange, Reimar Wernich Thomsen
BACKGROUND: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 classification separates the spirometric 1-4 staging from the ABCD groups defined by symptoms and exacerbations. Little is known about how this new classification predicts mortality in patients with chronic obstructive pulmonary disease (COPD). We aimed to establish the predictive ability of the GOLD 2017 classification, compared with earlier classifications, for all-cause and respiratory mortality, both when using its main ABCD groups and when further subdividing according to spirometric 1-4 staging...
January 10, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29331310/blood-eosinophil-counts-as-a-guide-for-copd-treatment-strategies
#4
Nicolas Roche, Maeva Zysman, Pierre-Régis Burgel
No abstract text is available yet for this article.
January 10, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29325753/induced-hypothermia-in-patients-with-septic-shock-and-respiratory-failure-cass-a-randomised-controlled-open-label-trial
#5
Theis Skovsgaard Itenov, Maria Egede Johansen, Morten Bestle, Katrin Thormar, Lars Hein, Louise Gyldensted, Anne Lindhardt, Henrik Christensen, Stine Estrup, Henrik Planck Pedersen, Matthew Harmon, Uday Kant Soni, Silvia Perez-Protto, Nicolai Wesche, Ulrik Skram, John Asger Petersen, Thomas Mohr, Tina Waldau, Lone Musaeus Poulsen, Ditte Strange, Nicole P Juffermans, Daniel I Sessler, Else Tønnesen, Kirsten Møller, Dennis Karsten Kristensen, Alessandro Cozzi-Lepri, Jens D Lundgren, Jens-Ulrik Jensen
BACKGROUND: Animal models of serious infection suggest that 24 h of induced hypothermia improves circulatory and respiratory function and reduces mortality. We tested the hypothesis that a reduction of core temperature to 32-34°C attenuates organ dysfunction and reduces mortality in ventilator-dependent patients with septic shock. METHODS: In this randomised, controlled, open-label trial, we recruited patients from ten intensive care units (ICUs) in three countries in Europe and North America...
January 8, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29325752/body-temperature-in-sepsis-a-hot-topic
#6
Djillali Annane
No abstract text is available yet for this article.
January 8, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29273539/effectiveness-of-who-s-pragmatic-screening-algorithm-for-child-contacts-of-tuberculosis-cases-in-resource-constrained-settings-a-prospective-cohort-study-in-uganda
#7
Leonardo Martinez, Ye Shen, Andreas Handel, Srijita Chakraburty, Catherine M Stein, LaShaunda L Malone, W Henry Boom, Frederick D Quinn, Moses L Joloba, Christopher C Whalen, Sarah Zalwango
BACKGROUND: Tuberculosis is a leading cause of global childhood mortality; however, interventions to detect undiagnosed tuberculosis in children are underused. Child contact tracing has been widely recommended but poorly implemented in resource-constrained settings. WHO has proposed a pragmatic screening approach for managing child contacts. We assessed the effectiveness of this screening approach and alternative symptom-based algorithms in identifying secondary tuberculosis in a prospectively followed cohort of Ugandan child contacts...
December 19, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29273538/planning-ahead-to-avert-a-respiratory-winter-avalanche
#8
EDITORIAL
The Lancet Respiratory Medicine
No abstract text is available yet for this article.
December 19, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29273537/symptom-based-screening-of-children-with-household-tuberculosis-contact
#9
Ben J Marais
No abstract text is available yet for this article.
December 19, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29269004/redefining-pulmonary-hypertension
#10
Bradley A Maron, Evan L Brittain, Gaurav Choudhary, Mark T Gladwin
No abstract text is available yet for this article.
December 18, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29249325/outcomes-in-patients-with-non-small-cell-lung-cancer-and-acquired-thr790met-mutation-treated-with-osimertinib-a-genomic-study
#11
Chia-Chi Lin, Jin-Yuan Shih, Chong-Jen Yu, Chao-Chi Ho, Wei-Yu Liao, Jih-Hsing Lee, Tzu-Hsiu Tsai, Kang-Yi Su, Min-Shu Hsieh, Yih-Leong Chang, Ya-Ying Bai, Derek De-Rui Huang, Kenneth S Thress, James Chih-Hsin Yang
BACKGROUND: Osimertinib is approved for the treatment of non-small-cell lung cancer in patients who develop the EGFR Thr790Met mutation after treatment with epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs). We assessed outcomes in patients with non-small-cell lung cancer and the EGFR Thr790Met mutation who were treated with osimertinib, a third-generation EGFR TKI, after previous treatment failure with one or more other EGFR TKIs. METHODS: Eligible patients had been enrolled at one centre in the AURA study, had shown resistance to a previous EGFR TKI, and had EGFR-activating mutations and acquired Thr790Met mutation detectable in tumour tissue or plasma...
December 14, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29249324/dna-shedding-in-non-small-cell-lung-cancer-useful-to-assess
#12
Kenichi Suda
No abstract text is available yet for this article.
December 14, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29248433/physiotherapy-breathing-retraining-for-asthma-a-randomised-controlled-trial
#13
Anne Bruton, Amanda Lee, Lucy Yardley, James Raftery, Emily Arden-Close, Sarah Kirby, Shihua Zhu, Manimekalai Thiruvothiyur, Frances Webley, Lyn Taylor, Denise Gibson, Guiqing Yao, Mark Stafford-Watson, Jenny Versnel, Michael Moore, Steve George, Paul Little, Ratko Djukanovic, David Price, Ian D Pavord, Stephen T Holgate, Mike Thomas
BACKGROUND: Despite effective pharmacotherapy, asthma continues to impair quality of life for most patients. Non-pharmacological approaches, including breathing retraining, are therefore of great interest to patients. However, clinicians rarely advocate breathing retraining and access to this intervention is restricted for most patients due to the limited availability of suitable physiotherapists and poor integration of breathing retraining into standard care. We aimed to assess the effectiveness of a digital self-guided breathing retraining intervention...
December 13, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29248432/remote-or-in-person-breathing-retraining-for-uncontrolled-asthma-symptoms
#14
John D Blakey, Renu Abraham
No abstract text is available yet for this article.
December 13, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29248431/tezacaftor-ivacaftor-is-safe-and-efficacious-in-patients-with-cystic-fibrosis-with-phe508del-mutations
#15
Tony Kirby
No abstract text is available yet for this article.
December 13, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29241977/patients-with-ipf-and-lung-cancer-diagnosis-and-management
#16
Argyris Tzouvelekis, Paolo Spagnolo, Francesco Bonella, Carlo Vancheri, Vasilios Tzilas, Bruno Crestani, Michael Kreuter, Demosthenes Bouros
No abstract text is available yet for this article.
December 11, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29217462/e-cigarettes-further-flavours-of-controversy-within-the-controversy
#17
David Bareham, Keivan Ahmadi, Mathieu Elie, Arwel W Jones, Martin McKee
No abstract text is available yet for this article.
December 4, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29217461/the-irresponsible-promotion-of-e-cigarettes-and-swaptober
#18
LETTER
Stuart W Flint, Arwel W Jones
No abstract text is available yet for this article.
December 4, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29196047/antibiotic-administration-in-the-ambulance
#19
Jean-Louis Vincent
No abstract text is available yet for this article.
November 28, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29196046/prehospital-antibiotics-in-the-ambulance-for-sepsis-a-multicentre-open-label-randomised-trial
#20
Nadia Alam, Erick Oskam, Patricia M Stassen, Pieternel van Exter, Peter M van de Ven, Harm R Haak, Frits Holleman, Arthur van Zanten, Hien van Leeuwen-Nguyen, Victor Bon, Bart A M Duineveld, Rishi S Nannan Panday, Mark H H Kramer, Prabath W B Nanayakkara
BACKGROUND: Emergency medical services (EMS) personnel have already made substantial contributions to improving care for patients with time-dependent illnesses, such as trauma and myocardial infarction. Patients with sepsis could also benefit from timely prehospital care. METHODS: After training EMS personnel in recognising sepsis, we did a randomised controlled open-label trial in ten large regional ambulance services serving 34 secondary and tertiary care hospitals in the Netherlands...
November 28, 2017: Lancet Respiratory Medicine
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