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Lancet Respiratory Medicine

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https://www.readbyqxmd.com/read/28545978/benralizumab-for-patients-with-mild-to-moderate-persistent-asthma-bise-a-randomised-double-blind-placebo-controlled-phase-3-trial
#1
Gary T Ferguson, J Mark FitzGerald, Eugene R Bleecker, Michel Laviolette, David Bernstein, Craig LaForce, Lyndon Mansfield, Peter Barker, Yanping Wu, Maria Jison, Mitchell Goldman
BACKGROUND: Benralizumab is a humanised, anti-interleukin 5 receptor α monoclonal antibody that directly and rapidly depletes eosinophils, reduces asthma exacerbations, and improves lung function for patients with severe eosinophilic asthma. The objective of this trial was to assess the safety and efficacy of benralizumab for patients with mild to moderate, persistent asthma. METHODS: In this randomised, double-blind, placebo-controlled, phase 3 trial, we recruited patients aged 18-75 years, weighing at least 40 kg, and with a postbronchodilator reversibility in forced expiratory volume in 1 s (FEV1) of at least 12% at screening, from 52 clinical research centres in six countries...
May 22, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28529101/enhancing-preparedness-for-tackling-new-epidemic-threats
#2
Alimuddin Zumla, Giuseppe Ippolito, Brian McCloskey, Matthew Bates, Rashid Ansumana, David Heymann, Richard Kock, Francine Ntoumi
No abstract text is available yet for this article.
May 18, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28532664/corrections
#3
(no author information available yet)
No abstract text is available yet for this article.
May 16, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28526233/keratinocyte-growth-factor-for-the-treatment-of-the-acute-respiratory-distress-syndrome-kare-a-randomised-double-blind-placebo-controlled-phase-2-trial
#4
Daniel F McAuley, Lj Mark Cross, Umar Hamid, Evie Gardner, J Stuart Elborn, Kathy M Cullen, Ahilanandan Dushianthan, Michael Pw Grocott, Michael A Matthay, Cecilia M O'Kane
BACKGROUND: Data from in-vitro, animal, and human lung injury models suggest that keratinocyte growth factor (KGF) might be beneficial in acute respiratory distress syndrome (ARDS). The objective of this trial was to investigate the effect of KGF in patients with ARDS. METHODS: We did a double-blind, allocation concealed, randomised, placebo-controlled phase 2 trial in two intensive care units in the UK, involving patients fulfilling the American-European Consensus Conference Definition of ARDS...
May 16, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28526232/keratinocyte-growth-factor-in-acute-respiratory-distress-syndrome
#5
István Vadász
No abstract text is available yet for this article.
May 16, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28522353/serotherapy-for-patients-with-severe-influenza
#6
Dorothy Scott, Jay S Epstein, Frederick G Hayden
No abstract text is available yet for this article.
May 15, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28522352/immune-plasma-for-the-treatment-of-severe-influenza-an-open-label-multicentre-phase-2-randomised-study
#7
John H Beigel, Pablo Tebas, Marie-Carmelle Elie-Turenne, Ednan Bajwa, Todd E Bell, Charles B Cairns, Shmuel Shoham, Jaime G Deville, Eric Feucht, Judith Feinberg, Thomas Luke, Kanakatte Raviprakash, Janine Danko, Dorothy O'Neil, Julia A Metcalf, Karen King, Timothy H Burgess, Evgenia Aga, H Clifford Lane, Michael D Hughes, Richard T Davey
BACKGROUND: Influenza causes substantial morbidity and mortality despite available treatments. Anecdotal reports suggest that plasma with high antibody titres to influenza might be of benefit in the treatment of severe influenza. METHODS: In this randomised, open-label, multicentre, phase 2 trial, 29 academic medical centres in the USA assessed the safety and efficacy of anti-influenza plasma with haemagglutination inhibition antibody titres of 1:80 or more to the infecting strain...
May 15, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28522351/effect-of-early-supplemental-parenteral-nutrition-in-the-paediatric-icu-a-preplanned-observational-study-of-post-randomisation-treatments-in-the-pepanic-trial
#8
Ilse Vanhorebeek, Sascha Verbruggen, Michaël P Casaer, Jan Gunst, Pieter J Wouters, Jan Hanot, Gonzalo Garcia Guerra, Dirk Vlasselaers, Koen Joosten, Greet Van den Berghe
BACKGROUND: Large randomised controlled trials have shown that early supplemental parenteral nutrition in patients admitted to adult and paediatric intensive care units (PICUs) is harmful. Overdosing of energy with too little protein was suggested as a potential reason for this. This study analysed which macronutrient was associated with harm caused by early supplemental parenteral nutrition in the Paediatric Early versus Late Parenteral Nutrition In Critical Illness (PEPaNIC) randomised trial...
May 15, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28522350/protein-provision-in-the-critically-ill-child-is-less-more
#9
Chengsi Ong, Jan Hau Lee
No abstract text is available yet for this article.
May 15, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28522349/respiratory-medicine-and-critical-care-a-call-for-papers-for-ers
#10
Laura Feetham, Sabine Kleinert
No abstract text is available yet for this article.
May 15, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28506429/deteriorating-respiratory-health-in-nepal-a-call-for-action
#11
Rajshree Thapa, Shiva Raj Mishra, Rupesh Gautam
No abstract text is available yet for this article.
May 11, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28495414/the-nhs-is-no-place-for-immigration-enforcement
#12
EDITORIAL
The Lancet Respiratory Medicine
No abstract text is available yet for this article.
May 8, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28483403/uk-government-must-publish-air-pollution-strategy
#13
Talha Khan Burki
No abstract text is available yet for this article.
May 5, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28483402/doxycycline-for-outpatient-treated-acute-exacerbations-of-copd-a-randomised-double-blind-placebo-controlled-trial
#14
Patricia van Velzen, Gerben Ter Riet, Paul Bresser, Jeroen J Baars, Bob T J van den Berg, Jan W K van den Berg, Paul Brinkman, Jennece W F Dagelet, Johannes M A Daniels, Dewi R G L Groeneveld-Tjiong, René E Jonkers, Coen van Kan, Frans H Krouwels, Karin Pool, Arjan Rudolphus, Peter J Sterk, Jan M Prins
BACKGROUND: Antibiotics do not reduce mortality or short-term treatment non-response in patients receiving treatment for acute exacerbations of COPD in an outpatient setting. However, the long-term effects of antibiotics are unknown. The aim of this study was to investigate if the antibiotic doxycycline added to the oral corticosteroid prednisolone prolongs time to next exacerbation in patients with COPD receiving treatment for an exacerbation in the outpatient setting. METHODS: In this randomised double-blind placebo-controlled trial, we recruited a cohort of patients with COPD from outpatient clinics of nine teaching hospitals and three primary care centres in the Netherlands...
May 5, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28483401/antibiotics-for-copd-exacerbations
#15
Wassim W Labaki, MeiLan K Han
No abstract text is available yet for this article.
May 5, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28461201/corrections
#16
(no author information available yet)
No abstract text is available yet for this article.
April 28, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28462898/latin-america-makes-progress-on-tobacco-control
#17
Talha Khan Burki
No abstract text is available yet for this article.
April 24, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28438502/us-drug-shortages-might-have-led-to-more-patient-deaths
#18
Bryant Furlow
No abstract text is available yet for this article.
April 21, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28438501/fatigue-in-copd-an-important-yet-ignored-symptom
#19
Martijn A Spruit, Jan H Vercoulen, Mirjam A G Sprangers, Emiel F M Wouters
No abstract text is available yet for this article.
April 21, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28412184/clinical-trial-research-in-focus-why-do-so-many-clinical-trials-fail-in-ipf
#20
Paolo Spagnolo, Toby M Maher
No abstract text is available yet for this article.
April 12, 2017: Lancet Respiratory Medicine
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