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Lancet Respiratory Medicine

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https://www.readbyqxmd.com/read/28918970/corrections
#1
(no author information available yet)
No abstract text is available yet for this article.
September 14, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28923239/a-novel-formulation-of-inhaled-sodium-cromoglicate-pa101-in-idiopathic-pulmonary-fibrosis-and-chronic-cough-a-randomised-double-blind-proof-of-concept-phase-2-trial
#2
Surinder S Birring, Marlies S Wijsenbeek, Sanjay Agrawal, Jan W K van den Berg, Helen Stone, Toby M Maher, Ahmet Tutuncu, Alyn H Morice
BACKGROUND: Cough can be a debilitating symptom of idiopathic pulmonary fibrosis (IPF) and is difficult to treat. PA101 is a novel formulation of sodium cromoglicate delivered via a high-efficiency eFlow nebuliser that achieves significantly higher drug deposition in the lung compared with the existing formulations. We aimed to test the efficacy and safety of inhaled PA101 in patients with IPF and chronic cough and, to explore the antitussive mechanism of PA101, patients with chronic idiopathic cough (CIC) were also studied...
September 8, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28923238/old-drug-new-tricks-reducing-cough-in-ipf
#3
Stuart B Mazzone
No abstract text is available yet for this article.
September 8, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28919201/macitentan-for-the-treatment-of-inoperable-chronic-thromboembolic-pulmonary-hypertension-merit-1-results-from-the-multicentre-phase-2-randomised-double-blind-placebo-controlled-study
#4
Hossein-Ardeschir Ghofrani, Gérald Simonneau, Andrea M D'Armini, Peter Fedullo, Luke S Howard, Xavier Jaïs, David P Jenkins, Zhi-Cheng Jing, Michael M Madani, Nicolas Martin, Eckhard Mayer, Kelly Papadakis, Dominik Richard, Nick H Kim
BACKGROUND: Macitentan is beneficial for long-term treatment of pulmonary arterial hypertension. The microvasculopathy of chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension are similar. METHODS: The phase 2, double-blind, randomised, placebo-controlled MERIT-1 trial assessed macitentan in 80 patients with CTEPH adjudicated as inoperable. Patients identified as WHO functional class II-IV with a pulmonary vascular resistance (PVR) of at least 400 dyn·s/cm(5) and a walk distance of 150-450 m in 6 min were randomly assigned (1:1), via an interactive voice/web response system, to receive oral macitentan (10 mg once a day) or placebo...
September 8, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28919200/predictors-of-enhanced-response-with-benralizumab-for-patients-with-severe-asthma-pooled-analysis-of-the-sirocco-and-calima-studies
#5
J Mark FitzGerald, Eugene R Bleecker, Andrew Menzies-Gow, James G Zangrilli, Ian Hirsch, Paul Metcalfe, Paul Newbold, Mitchell Goldman
BACKGROUND: Benralizumab is an anti-eosinophilic, anti-interleukin-5 receptor α monoclonal antibody that has been shown to significantly reduce asthma exacerbations and improve lung function for patients with severe, uncontrolled asthma. We further explored the efficacy of benralizumab for patients with different baseline blood eosinophil thresholds and exacerbation histories. METHODS: This study is a pooled analysis of the results from the randomised, double-blind, placebo-controlled SIROCCO (NCT01928771) and CALIMA (NCT01914757) phase 3 studies...
September 8, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28919199/increasing-confidence-in-the-therapeutic-relevance-of-eosinophils-in-severe-asthma
#6
Marc Humbert
No abstract text is available yet for this article.
September 8, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28919198/macitentan-for-treatment-of-cteph-why-merit-merits-attention
#7
Adam Torbicki
No abstract text is available yet for this article.
September 8, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28888349/trump-administration-halts-mountaintop-coal-mining-health-study
#8
Bryant Furlow
No abstract text is available yet for this article.
September 6, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28887015/bedaquiline-or-delamanid-for-rifampin-resistant-tuberculosis
#9
Erica Lessem, Vivian Cox, Jennifer Furin
No abstract text is available yet for this article.
September 5, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28870698/asbestos-insights-from-women
#10
Deborah H Yates
No abstract text is available yet for this article.
September 1, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28865676/determining-the-outcomes-of-interventions-to-prevent-respiratory-syncytial-virus-disease-in-children-what-to-measure
#11
REVIEW
Ruth A Karron, Heather J Zar
Respiratory syncytial virus (RSV) is the most common cause of viral acute lower respiratory tract illness (LRTI) in young children, and a major cause of hospital admissions and health-care utilisation globally. Substantial efforts have been made to develop RSV vaccines and vaccine-like monoclonal antibodies to prevent acute RSV LRTI. Prevention of acute disease could improve long-term lung health, with potential effects on wheezing, asthma, and chronic lung disease. This Personal View describes assessments that should be initiated during clinical trials and continued after licensure to fully evaluate the effect of RSV preventive interventions...
August 30, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28864057/the-road-to-precision-medicine-in-sepsis-blood-transcriptome-endotypes
#12
Carlos Flores, Jesus Villar
No abstract text is available yet for this article.
August 29, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28864056/classification-of-patients-with-sepsis-according-to-blood-genomic-endotype-a-prospective-cohort-study
#13
Brendon P Scicluna, Lonneke A van Vught, Aeilko H Zwinderman, Maryse A Wiewel, Emma E Davenport, Katie L Burnham, Peter Nürnberg, Marcus J Schultz, Janneke Horn, Olaf L Cremer, Marc J Bonten, Charles J Hinds, Hector R Wong, Julian C Knight, Tom van der Poll
BACKGROUND: Host responses during sepsis are highly heterogeneous, which hampers the identification of patients at high risk of mortality and their selection for targeted therapies. In this study, we aimed to identify biologically relevant molecular endotypes in patients with sepsis. METHODS: This was a prospective observational cohort study that included consecutive patients admitted for sepsis to two intensive care units (ICUs) in the Netherlands between Jan 1, 2011, and July 20, 2012 (discovery and first validation cohorts) and patients admitted with sepsis due to community-acquired pneumonia to 29 ICUs in the UK (second validation cohort)...
August 29, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28822788/taking-on-a-new-significance
#14
EDITORIAL
The Lancet Respiratory Medicine
No abstract text is available yet for this article.
August 16, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28784580/diesel-and-petrol-cars-to-be-banned-by-2040
#15
Aaron van Dorn
No abstract text is available yet for this article.
August 4, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28784579/uk-government-announces-new-life-sciences-inquiry
#16
Kathryn Clark
No abstract text is available yet for this article.
August 4, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28781029/hospital-acquired-pneumonia-surveillance-an-unmet-need
#17
Victoria C Ewan, Miles D Witham, Martin Kiernan, A John Simpson
No abstract text is available yet for this article.
August 3, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28780183/does-inhaled-steroid-therapy-help-emerging-asthma-in-early-childhood
#18
REVIEW
Elissa M Abrams, Stanley J Szefler, Allan B Becker
Although early childhood wheeze is common, persistent asthma is less common. However, of those children who do progress to persistent asthma, lung function abnormalities and airway remodelling can already be seen early in life and can increase in magnitude with time. There has been a general expectation that early use of inhaled corticosteroid (ICS) could change the natural history of asthma if started in the young child with wheeze. Despite this expectation, the role of ICS therapy in altering the natural course of disease in children with emerging asthma is not well defined...
August 2, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28736044/high-dose-influenza-vaccine-in-nursing-home-residents-not-to-be-sneezed-at
#19
Marc-Alain Widdowson, Joseph S Bresee
No abstract text is available yet for this article.
July 20, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28734825/trials-of-statins-in-delirium-stymied-by-complex-methods
#20
Yoanna Skrobik, John Devlin
No abstract text is available yet for this article.
July 19, 2017: Lancet Respiratory Medicine
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