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Journal of Stroke

Bo-Ching Lee, Cheng-Li Lin, Hsin-Hsi Tsai, Chia-Hung Kao
No abstract text is available yet for this article.
September 2018: Journal of Stroke
Liang Shu, Johannes Meyne, Olav Jansen, Ulf Jensen-Kondering
No abstract text is available yet for this article.
September 2018: Journal of Stroke
Tapan Mehta, Smit Patel, Shailesh Male, Romil Parikh, Kathan Mehta, Kamakshi Lakshminarayan, Ramachandra Tummala, Mustapha Ezzeddine
No abstract text is available yet for this article.
September 2018: Journal of Stroke
Jong S Kim, Han Bin Lee, Hyuck Sung Kwon
No abstract text is available yet for this article.
September 2018: Journal of Stroke
Jin Soo Lee, Seong-Joon Lee, Joon Sang Yoo, Jeong-Ho Hong, Chang-Hyun Kim, Yong-Won Kim, Dong-Hun Kang, Yong-Sun Kim, Ji Man Hong, Jin Wook Choi, Bruce Ovbiagele, Andrew M Demchuk, Sung-Il Sohn, Yang-Ha Hwang
BACKGROUND AND PURPOSE: Little is known about prognosis after endovascular therapy (EVT) for acute large artery occlusion (LAO) caused by underlying intracranial atherosclerotic stenosis (ICAS). Therefore, we investigated the prognosis following EVT according to the underlying etiology of LAO. METHODS: Patients from the Acute Stroke due to Intracranial Atherosclerotic occlusion and Neurointervention-Korean Retrospective (ASIAN KR) registry (n=720) were included if their occlusion was in the intracranial anterior circulation and their onset-to-puncture time was <24 hours...
September 2018: Journal of Stroke
Federico Di Maria, Mikael Mazighi, Maéva Kyheng, Julien Labreuche, Georges Rodesch, Arturo Consoli, Oguzhan Coskun, Benjamin Gory, Bertrand Lapergue
BACKGROUND AND PURPOSE: Recent single-center series and meta-analyses suggest that mechanical thrombectomy (MT) without prior intravenous thrombolysis (IVT) might be equally effective to bridging therapy. We analyzed, within the Endovascular Treatment in Ischemic Stroke (ETIS) prospective observational registry, the angiographic and clinical outcomes after IVT+MT versus MT alone. METHODS: From December 2012 to December 2016, a total of 1,507 consecutive patients with a proximal arterial occlusion of the anterior circulation were treated by MT...
September 2018: Journal of Stroke
Slaven Pikija, Vladimir Trkulja, Christian Ramesmayer, Johannes S Mutzenbach, Monika Killer-Oberpfalzer, Constantin Hecker, Nele Bubel, Michael Ulrich Füssel, Johann Sellner
BACKGROUND AND PURPOSE: Reports investigating the relationship between in-procedure blood pressure (BP) and outcomes in patients undergoing endovascular thrombectomy (EVT) due to anterior circulation stroke are sparse and contradictory. METHODS: Consecutive EVT-treated adults (modern stent retrievers, BP managed in line with the recommendations, general anesthesia, invasive BP measurements) were evaluated for associations of the rate of in-procedure systolic BP (SBP) and mean arterial pressure (MAP) excursions to >120%/<80% of the reference values (serial measurements at anesthesia induction) and of the reference BP/weighted in-procedure mean BP with post-procedure imaging outcomes (ischemic lesion volume [ILV], hemorrhages) and 3-month functional outcome (modified Rankin Scale [mRS], score 0 to 2 vs...
September 2018: Journal of Stroke
Katharina Schregel, Ioannis Tsogkas, Carolin Peter, Antonia Zapf, Daniel Behme, Marlena Schnieder, Ilko L Maier, Jan Liman, Michael Knauth, Marios-Nikos Psychogios
BACKGROUND AND PURPOSE: Collateral status is an important factor determining outcome in acute ischemic stroke (AIS). Hence, different collateral scoring systems have been introduced. We applied different scoring systems on single- and multi-phase computed tomography (CT) angiography (spCTA and mpCTA) and compared them to CT perfusion (CTP) parameters to identify the best method for collateral evaluation in patients with AIS. METHODS: A total of 102 patients with AIS due to large vessel occlusion in the anterior circulation who underwent multimodal CT imaging and who were treated endovascularly were included...
September 2018: Journal of Stroke
Hye Youn Sung, Ji Yeoun Lee, Ae Kyung Park, Youn Joo Moon, Inho Jo, Eun-Mi Park, Kyu-Chang Wang, Ji Hoon Phi, Jung-Hyuck Ahn, Seung-Ki Kim
BACKGROUND AND PURPOSE: The pathogenesis of moyamoya disease (MMD) remains poorly understood, and no reliable molecular biomarkers for MMD have been identified to date. The present study aimed to identify epigenetic biomarkers for use in the diagnosis of MMD. METHODS: We performed integrated analyses of gene expression profiles and DNA methylation profiles in endothelial colony forming cells (ECFCs) from three patients with MMD and two healthy individuals. Candidate gene mRNA expression and DNA methylation status were further validated using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and pyrosequencing analysis of an expanded ECFC sample set from nine patients with MMD and ten controls...
September 2018: Journal of Stroke
Lu Zheng, Wen Jie Yang, Chun Bo Niu, Hai Lu Zhao, Ka Sing Wong, Thomas Wai Hong Leung, Xiang Yan Chen
BACKGROUND AND PURPOSE: Vasa vasorum (VV) have been believed to be rare or non-existent in small-caliber intracranial arteries. In a series of human cerebral artery specimens, we identified and examined the distribution of VV in association with co-existing intracranial atherosclerosis. METHODS: We obtained cerebral artery specimens from 32 consecutive autopsies of subjects aged 45 years or above. We scrutinized middle cerebral artery (MCA), vertebral artery (VA), and basilar artery (BA) for the presence of adventitial VV...
September 2018: Journal of Stroke
Annick Kronenburg, Esther van den Berg, Monique M van Schooneveld, Kees P J Braun, Lionel Calviere, Albert van der Zwan, Catharina J M Klijn
BACKGROUND AND PURPOSE: Patients with moyamoya vasculopathy (MMV) may experience cognitive impairment, but its reported frequency, severity, and nature vary. In a systematic review and metaanalysis, we aimed to assess the presence, severity, and nature of cognitive impairments in children and adults with MMV. METHODS: We followed the MOOSE guidelines for meta-analysis and systematic reviews of observational studies. We searched Ovid Medline and Embase for studies published between January 1, 1969 and October 4, 2016...
September 2018: Journal of Stroke
Kazunori Toyoda, Hiroshi Yamagami, Masatoshi Koga
Development of direct oral anticoagulants and their antidotes has led to the need to reconsider the eligibility of acute stroke patients who have been taking oral anticoagulants for intravenous thrombolysis. Officially authorized Japanese guidelines on this issue were revised twice at the time of approval for clinical use of direct oral anticoagulants and idarucizumab, a specific reversal agent for dabigatran. A unique recommendation in the latest Japanese clinical guides was that thrombolysis can be recommended if the time of the last dose of direct oral anticoagulants exceeds 4 hours and if commonly available anticoagulation markers are normal or subnormal, i...
September 2018: Journal of Stroke
Elisa Cuadrado-Godia, Pratistha Dwivedi, Sanjiv Sharma, Angel Ois Santiago, Jaume Roquer Gonzalez, Mercedes Balcells, John Laird, Monika Turk, Harman S Suri, Andrew Nicolaides, Luca Saba, Narendra N Khanna, Jasjit S Suri
Cerebral small vessel disease (cSVD) has a crucial role in lacunar stroke and brain hemorrhages and is a leading cause of cognitive decline and functional loss in elderly patients. Based on underlying pathophysiology, cSVD can be subdivided into amyloidal and non-amyloidal subtypes. Genetic factors of cSVD play a pivotal role in terms of unraveling molecular mechanism. An important pathophysiological mechanism of cSVD is blood-brain barrier leakage and endothelium dysfunction which gives a clue in identification of the disease through circulating biological markers...
September 2018: Journal of Stroke
Thorsten Steiner, Martin Köhrmann, Peter D Schellinger, Georgios Tsivgoulis
Oral anticoagulant-associated intracerebral hemorrhage (OAC-ICH) accounts for nearly 20% of all ICH. The number of patients with an indication for oral anticoagulant therapy (OAT) increases with increasing age. OAT became less complicate with the introduction of non-vitamin K oral anticoagulants (NOAC) OAT because of easier handling, favorable risk-benefit profile, reduced rates of ICH compared to vitamin K antagonists and no need for routine coagulation testing. Consequently, despite a better safety profile of NOAC the number of patients with OAC-ICH will increase...
September 2018: Journal of Stroke
Peter D Schellinger, Georgios Tsivgoulis, Thorsten Steiner, Martin Köhrmann
The authors review the current status of percutaneous left atrial appendage (LAA) occlusion therapy in patients with atrial fibrillation with the goal to prevent ischemic stroke and systemic embolism and to reduce oral anticoagulation associated bleeding. While we cover the historical and also surgical background, and all tested devices, the main focus rests on the single currently U.S. Food and Drug Administration (FDA) approved LAA occluder, the WATCHMAN device, and its approval process. The authors also give a critical appraisal beyond the review of mere facts, trying to put the current data into perspective...
September 2018: Journal of Stroke
Mahesh Kate, Robert Wannamaker, Harsha Kamble, Parnian Riaz, Laura C Gioia, Brian Buck, Thomas Jeerakathil, Penelope Smyth, Ashfaq Shuaib, Derek Emery, Kenneth Butcher
No abstract text is available yet for this article.
September 2018: Journal of Stroke
Romain Bourcier, Mickael Mazighi, Julien Labreuche, Robert Fahed, Raphael Blanc, Benjamin Gory, Alain Duhamel, Gaultier Marnat, Suzana Saleme, Vincent Costalat, Serge Bracard, Hubert Desal, Arturo Consoli, Michel Piotin, Bertrand Lapergue
No abstract text is available yet for this article.
September 2018: Journal of Stroke
Georgios Tsivgoulis, Apostolos Safouris, Dong-Eog Kim, Andrei V Alexandrov
No abstract text is available yet for this article.
September 2018: Journal of Stroke
Ángel Chamorro
For decades, numerous pharmacological and non-pharmacological strategies have been evaluated without success to limit the consequences of the ischemic cascade, but more rarely the therapies were explored as add on remedies on individuals also receiving reperfusion therapies. It is plausible that these putative neuroprotectants never reached the ischemic brain in adequate concentrations. Currently, the concept of neuroprotection incorporates cerebral perfusion as an obligatory substrate upon which ischemic brain survival depends, and it is plausible that some of the compounds tested in previous neuroprotection trials might have resulted in more favorable results if reperfusion therapies had been co-administered...
May 2018: Journal of Stroke
Eun-Jae Lee, Jong S Kim, Dae-Il Chang, Jong-Ho Park, Seong Hwan Ahn, Jae-Kwan Cha, Ji Hoe Heo, Sung-Il Sohn, Byung-Chul Lee, Dong-Eog Kim, Hahn Young Kim, Seongheon Kim, Do-Young Kwon, Jei Kim, Woo-Keun Seo, Jun Lee, Sang-Won Park, Seong-Ho Koh, Jin Young Kim, Smi Choi-Kwon, Min-Sun Kim, Ji Sung Lee
BACKGROUND AND PURPOSE: The pathophysiology of post-stroke depression (PSD) is complex and may differ according to an individual's mood immediately after stroke. Here, we compared the therapeutic response and clinical characteristics of PSD at a later stage between patients with and without depression immediately after stroke. METHODS: This study involved a post hoc analysis of data from EMOTION ( NCT01278498), a placebo-controlled, double-blind trial that examined the efficacy of escitalopram (10 mg/day) on PSD and other emotional disturbances among 478 patients with acute stroke...
May 2018: Journal of Stroke
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