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Journal of Stroke

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https://www.readbyqxmd.com/read/29402073/ethnic-differences-in-intracranial-artery-tortuosity-a-possible-reason-for-different-locations-of-cerebral-atherosclerosis
#1
Bum Joon Kim, Kyung Mi Lee, Sung-Ho Lee, Hyug-Gi Kim, Eui Jong Kim, Sung Hyuk Heo, Dae-Il Chang, Jong S Kim
No abstract text is available yet for this article.
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402072/air-pollution-and-stroke
#2
REVIEW
Kuan Ken Lee, Mark R Miller, Anoop S V Shah
The adverse health effects of air pollution have long been recognised; however, there is less awareness that the majority of the morbidity and mortality caused by air pollution is due to its effects on the cardiovascular system. Evidence from epidemiological studies have demonstrated a strong association between air pollution and cardiovascular diseases including stroke. Although the relative risk is small at an individual level, the ubiquitous nature of exposure to air pollution means that the absolute risk at a population level is on a par with "traditional" risk factors for cardiovascular disease...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402071/sleep-disturbances-as-a-risk-factor-for-stroke
#3
REVIEW
Dae Lim Koo, Hyunwoo Nam, Robert J Thomas, Chang-Ho Yun
Sleep, a vital process of human being, is carefully orchestrated by the brain and consists of cyclic transitions between rapid eye movement (REM) and non-REM (NREM) sleep. Autonomic tranquility during NREM sleep is characterized by vagal dominance and stable breathing, providing an opportunity for the cardiovascular-neural axis to restore homeostasis, in response to use, distress or fatigue inflicted during wakefulness. Abrupt irregular swings in sympathovagal balance during REM sleep act as phasic loads on the resting cardiovascular system...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402070/heart-failure-as-a-risk-factor-for-stroke
#4
REVIEW
Woohyeun Kim, Eung Ju Kim
Heart failure (HF) is one of the major causes of death worldwide. Despite the high incidence of stroke in patients with HF, there has been a controversy as to whether HF itself is a risk factor for stroke. Recently, there is a great deal of evidence that HF itself increases the risk of stroke. In previous studies, the benefit of warfarin for stroke prevention in patients with HF was offset by the risk of bleeding. In the era of non-vitamin K antagonist oral anticoagulants with low bleeding profiles, we can expect a more effective stroke prevention in patients with HF by selective anticoagulation...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402069/treatments-to-promote-neural-repair-after-stroke
#5
REVIEW
Steven C Cramer
Stroke remains a major cause of human disability worldwide. In parallel with advances in acute stroke interventions, new therapies are under development that target restorative processes. Such therapies have a treatment time window measured in days, weeks, or longer and so have the advantage that they may be accessible by a majority of patients. Several categories of restorative therapy have been studied and are reviewed herein, including drugs, growth factors, monoclonal antibodies, activity-related therapies including telerehabilitation, and a host of devices such as those related to brain stimulation or robotics...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402068/association-of-microrna-biogenesis-genes-polymorphisms-with-ischemic-stroke-susceptibility-and-post-stroke-mortality
#6
Jung Oh Kim, Jinkun Bae, Jinkwon Kim, Seung Hun Oh, Hui Jeong An, In Bo Han, Doyeun Oh, Ok Joon Kim, Nam Keun Kim
BACKGROUND AND PURPOSE: MicroRNA (miRNA) expression has been examined in multiple conditions, including various cancers, neurological diseases, and cerebrovascular diseases, particularly stroke. Existing evidence indicates that miRNA biosynthesis and function play crucial roles in ischemic stroke physiology and pathology. In this study, we selected six known polymorphisms in miRNA-biogenesis genes; DICER rs13078A>T, rs3742330A>G; DROSHA rs10719T>C, rs6877842G>C; Ran GTPase ( RAN ) rs14035C>T; exportin 5 ( XPO5 ) rs11077A>C...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402067/differences-between-the-molecular-mechanisms-underlying-ruptured-and-non-ruptured-carotid-plaques-and-the-significance-of-abca1
#7
Sung Hyuk Heo, Eun-Hye Lee, Hyun-Hee Park, Bum Joon Kim, Hyo Chul Youn, Young Seo Kim, Hyun Young Kim, Seong-Ho Koh, Dae-Il Chang
BACKGROUND AND PURPOSE: Carotid plaques are a strong risk factor for ischemic stroke, and plaque rupture poses an even higher risk. Although many studies have investigated the pathogenic mechanisms of carotid plaque formation, few have studied the differences in molecular mechanisms underlying the rupture and non-rupture of carotid plaques. In addition, since early diagnosis and treatment of carotid plaque rupture are critical for the prevention of ischemic stroke, many studies have sought to identify the important target molecules involved in the rupture...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402066/development-of-new-endovascular-devices-for-aneurysm-treatment
#8
REVIEW
Zhen Yu Jia, Hai Bin Shi, Shigeru Miyachi, Sun Moon Hwang, Jae Jon Sheen, Yun Sun Song, Joong Goo Kim, Deok Hee Lee, Dae Chul Suh
Since the first use of the Guglielmi detachable coil system for cerebral aneurysm embolization in 1990, various endovascular methods have been developed to treat large numbers of aneurysms. The main strategic and technical modifications introduced to date include balloon-assisted coil embolization, stent-assisted coil embolization, flow diverters, and flow disrupters. The development and introduction of such devices have been so persistent and rapid that new devices are being approved worldwide even before the earlier ones become available in some countries...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402065/incidental-statin-use-and-the-risk-of-stroke-or-transient-ischemic-attack-after-radiotherapy-for-head-and-neck-cancer
#9
Daniel Addison, Patrick R Lawler, Hamed Emami, Sumbal A Janjua, Pedro V Staziaki, Travis R Hallett, Orla Hennessy, Hang Lee, Bálint Szilveszter, Michael Lu, Negar Mousavi, Matthew G Nayor, Francesca N Delling, Javier M Romero, Lori J Wirth, Annie W Chan, Udo Hoffmann, Tomas G Neilan
BACKGROUND AND PURPOSE: Interventions to reduce the risk for cerebrovascular events (CVE; stroke and transient ischemic attack [TIA]) after radiotherapy (RT) for head and neck cancer (HNCA) are needed. Among broad populations, statins reduce CVEs; however, whether statins reduce CVEs after RT for HNCA is unclear. Therefore, we aimed to test whether incidental statin use at the time of RT is associated with a lower rate of CVEs after RT for HNCA. METHODS: From an institutional database we identified all consecutive subjects treated with neck RT from 2002 to 2012 for HNCA...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402064/low-versus-standard-dose-intravenous-alteplase-in-the-context-of-bridging-therapy-for-acute-ischemic-stroke-a-korean-enchanted-study
#10
Jong S Kim, Yeon-Jung Kim, Kyung Bok Lee, Jae Kwan Cha, Jong-Moo Park, Yangha Hwang, Eung-Gyu Kim, Joung-Ho Rha, Jaseong Koo, Jei Kim, Yong-Jae Kim, Woo-Keun Seo, Dong-Eog Kim, Thompson G Robinson, Richard I Lindley, Xia Wang, John Chalmers, Craig S Anderson
BACKGROUND AND PURPOSE: Following the positive results from recent trials on endovascular therapy (EVT), bridging therapy (intravenous alteplase plus EVT) is increasingly being used for the treatment of acute ischemic stroke. However, the optimal dose of intravenous alteplase remains unknown in centers where bridging therapy is actively performed. The optimal dose for eventual recanalization and positive clinical outcomes in patients receiving bridging therapy also remains unknown. METHODS: In this prospective Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) sub-study, we explored the outcomes following treatment with two different doses (low- [0...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402063/folic-acid-in-stroke-prevention-in-countries-without-mandatory-folic-acid-food-fortification-a-meta-analysis-of-randomized-controlled-trials
#11
Chia-Yu Hsu, Shao-Wen Chiu, Keun-Sik Hong, Jeffrey L Saver, Yi-Ling Wu, Jiann-Der Lee, Meng Lee, Bruce Ovbiagele
BACKGROUND AND PURPOSE: Additional folic acid (FA) treatment appears to have a neutral effect on reducing vascular risk in countries that mandate FA fortification of food (e.g., USA and Canada). However, it is uncertain whether FA therapy reduces stroke risk in countries without FA food fortification. The purpose of this study was to comprehensively evaluate the efficacy of FA therapy on stroke prevention in countries without FA food fortification. METHODS: PubMed, EMBASE, and clinicaltrials...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402062/basilar-artery-plaque-and-pontine-infarction-location-and-vascular-geometry
#12
Bum Joon Kim, Kyung Mi Lee, Hyun Young Kim, Young Seo Kim, Seong-Ho Koh, Sung Hyuk Heo, Dae-Il Chang
BACKGROUND AND PURPOSE: Subclinical atherosclerotic plaques are common in patients with pontine infarctions (PIs) but without basilar artery (BA) stenosis. We hypothesized that BA plaque locations may differ by PI type and vertical location as well as vertebrobasilar artery geometry. METHODS: Ninety-six patients with PI but without BA stenosis on magnetic resonance imaging (MRI) and magnetic resonance angiography were enrolled. PIs were classified by type (paramedian, deep, or lateral) and vertical location (rostral, middle, or caudal)...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402061/unconventional-yet-important-risk-factors-for-stroke
#13
Jong S Kim
No abstract text is available yet for this article.
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402060/penumbral-imaging-based-thrombolysis-with-tenecteplase-is-feasible-up-to-24-hours-after-symptom-onset
#14
Mahesh Kate, Robert Wannamaker, Harsha Kamble, Parnian Riaz, Laura C Gioia, Brian Buck, Thomas Jeerakathil, Penelope Smyth, Ashfaq Shuaib, Kenneth Butcher, Derek Emery
BACKGROUND AND PURPOSE: Thrombolysis >4.5 hours after ischemic stroke onset is unproven. We assessed the feasibility of tenecteplase (TNK) treatment in patients with evidence of an ischemic penumbra 4.5 to 24 hours after onset. METHODS: Acute ischemic stroke patients underwent perfusion computed tomography (CT)/magnetic resonance imaging. Patients with cerebral blood volume (CBV) or diffusion weighted imaging Alberta Stroke Program Early CT Scores (ASPECTS) >6 and mismatch score >2 (defined as >2 ASPECTS regions with delay on mean transit time maps and normal CBV) were eligible for treatment with TNK (0...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29081215/erratum-stroke-epidemiology-in-south-east-and-south-east-asia-a-review
#15
Narayanaswamy Venketasubramanian, Byung Woo Yoon, Jeyaraj Pandian, Jose C Navarro
[This corrects the article on p. 286 in vol. 19.].
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29037016/intracranial-atherosclerosis-where-are-we-now
#16
Jong S Kim
No abstract text is available yet for this article.
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29037015/comparison-of-spot-sign-blend-sign-and-black-hole-sign-for-outcome-prediction-in-patients-with-intracerebral-hemorrhage
#17
Peter B Sporns, Michael Schwake, André Kemmling, Jens Minnerup, Wolfram Schwindt, Thomas Niederstadt, Rene Schmidt, Uta Hanning
BACKGROUND AND PURPOSE: Blend sign (BS) and black hole sign (BHS) on non-contrast computed tomography (NCCT) and spot sign (SS) on CT-angiography (CTA) are indicators of early hematoma expansion in spontaneous intracerebral hemorrhage (ICH). However, their independent contributions to outcome have not been well explored. METHODS: In this retrospective study, inclusion criteria were: 1) spontaneous ICH and 2) NCCT and CTA performed on admission within 6 hours after onset of symptoms...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29037014/deep-into-the-brain-artificial-intelligence-in-stroke-imaging
#18
REVIEW
Eun-Jae Lee, Yong-Hwan Kim, Namkug Kim, Dong-Wha Kang
Artificial intelligence (AI), a computer system aiming to mimic human intelligence, is gaining increasing interest and is being incorporated into many fields, including medicine. Stroke medicine is one such area of application of AI, for improving the accuracy of diagnosis and the quality of patient care. For stroke management, adequate analysis of stroke imaging is crucial. Recently, AI techniques have been applied to decipher the data from stroke imaging and have demonstrated some promising results. In the very near future, such AI techniques may play a pivotal role in determining the therapeutic methods and predicting the prognosis for stroke patients in an individualized manner...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29037013/angioplasty-stenting-and-other-potential-treatments-of-atherosclerotic-stenosis-of-the-intracranial-arteries-past-present-and-future
#19
REVIEW
Ashley Wabnitz, Marc Chimowitz
Although there is an intuitive appeal to treat symptomatic stenotic intracranial arteries with endovascular therapies such as angioplasty and stenting, current data from randomized trials show intensive medical therapy is far superior for preventing stroke. This is in large part due to the high risk of peri-procedural stroke from angioplasty and stenting. If angioplasty and stenting is to emerge as a proven treatment for intracranial stenosis, endovascular techniques will need to become much safer, identification of patients with intracranial stenosis who are at particularly high risk of stroke despite intensive medical therapy will need to be targeted, and well-designed randomized trials will be necessary to show endovascular therapy is superior to medical therapy in these high-risk patients...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29037012/medical-treatment-of-intracranial-atherosclerosis-an-update
#20
REVIEW
Jong S Kim, Oh Young Bang
For patients with symptomatic intracranial atherosclerosis (ICAS), antithrombotic agents are the mainstay of therapy. Anticoagulation (warfarin) is not widely used since it is not more effective than aspirin and carries a high risk of bleeding. New oral anticoagulants are showing promise, but their use has not been investigated in appropriate clinical trials. Since the recurrent stroke risk is high with aspirin monotherapy, dual antiplatelets are considered in the early stage of symptomatic ICAS. Based on the Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events (CHANCE) and Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) results, aspirin plus clopidogrel has been recommended...
September 2017: Journal of Stroke
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