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Journal of Stroke

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https://www.readbyqxmd.com/read/30121972/penumbral-imaging-based-thrombolysis-with-tenecteplase-is-feasible-up-to-24-hours-after-symptom-onset
#1
Mahesh Kate, Robert Wannamaker, Harsha Kamble, Parnian Riaz, Laura C Gioia, Brian Buck, Thomas Jeerakathil, Penelope Smyth, Ashfaq Shuaib, Kenneth Butcher, Derek Emery
No abstract text is available yet for this article.
August 20, 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29961304/susceptibility-vessel-sign-in-the-aster-trial-higher-recanalization-rate-and-more-favourable-clinical-outcome-after-first-line-stent-retriever-compared-to-contact-aspiration
#2
Romain Bourcier, Mickael Mazighi, Julien Labreuche, Robert Fahed, Raphael Blanc, Benjamin Gory, Alain Duhamel, Gaultier Marnat, Suzana Saleme, Vincent Costalat, Serge Bracard, Hubert Desal, Arturo Consoli, Michel Piotin, Bertrand Lapergue
No abstract text is available yet for this article.
June 29, 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29961303/recent-advances-in-primary-and-secondary-prevention-of-atherosclerotic-stroke
#3
Georgios Tsivgoulis, Apostolos Safouris, Dong-Eog Kim, Andrei V Alexandrov
No abstract text is available yet for this article.
June 29, 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29886725/neuroprotectants-in-the-era-of-reperfusion-therapy
#4
REVIEW
Ángel Chamorro
For decades, numerous pharmacological and non-pharmacological strategies have been evaluated without success to limit the consequences of the ischemic cascade, but more rarely the therapies were explored as add on remedies on individuals also receiving reperfusion therapies. It is plausible that these putative neuroprotectants never reached the ischemic brain in adequate concentrations. Currently, the concept of neuroprotection incorporates cerebral perfusion as an obligatory substrate upon which ischemic brain survival depends, and it is plausible that some of the compounds tested in previous neuroprotection trials might have resulted in more favorable results if reperfusion therapies had been co-administered...
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29886724/differences-in-therapeutic-responses-and-factors-affecting-post-stroke-depression-at-a-later-stage-according-to-baseline-depression
#5
Eun-Jae Lee, Jong S Kim, Dae-Il Chang, Jong-Ho Park, Seong Hwan Ahn, Jae-Kwan Cha, Ji Hoe Heo, Sung-Il Sohn, Byung-Chul Lee, Dong-Eog Kim, Hahn Young Kim, Seongheon Kim, Do-Young Kwon, Jei Kim, Woo-Keun Seo, Jun Lee, Sang-Won Park, Seong-Ho Koh, Jin Young Kim, Smi Choi-Kwon, Min-Sun Kim, Ji Sung Lee
BACKGROUND AND PURPOSE: The pathophysiology of post-stroke depression (PSD) is complex and may differ according to an individual's mood immediately after stroke. Here, we compared the therapeutic response and clinical characteristics of PSD at a later stage between patients with and without depression immediately after stroke. METHODS: This study involved a post hoc analysis of data from EMOTION (ClinicalTrials.gov NCT01278498), a placebo-controlled, double-blind trial that examined the efficacy of escitalopram (10 mg/day) on PSD and other emotional disturbances among 478 patients with acute stroke...
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29886723/serum-neurofilament-light-chain-levels-are-related-to-small-vessel-disease-burden
#6
Marco Duering, Marek J Konieczny, Steffen Tiedt, Ebru Baykara, Anil Man Tuladhar, Esther van Leijsen, Philippe Lyrer, Stefan T Engelter, Benno Gesierich, Melanie Achmüller, Christian Barro, Ruth Adam, Michael Ewers, Martin Dichgans, Jens Kuhle, Frank-Erik de Leeuw, Nils Peters
BACKGROUND AND PURPOSE: Neurofilament light chain (NfL) is a blood marker for neuroaxonal damage. We assessed the association between serum NfL and cerebral small vessel disease (SVD), which is highly prevalent in elderly individuals and a major cause of stroke and vascular cognitive impairment. METHODS: Using a cross-sectional design, we studied 53 and 439 patients with genetically defined SVD (Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy [CADASIL]) and sporadic SVD, respectively, as well as 93 healthy controls...
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29886722/prevalence-and-risk-factors-of-cerebral-small-vessel-disease-in-a-chinese-population-based-sample
#7
Fei Han, Fei-Fei Zhai, Quan Wang, Li-Xin Zhou, Jun Ni, Ming Yao, Ming-Li Li, Shu-Yang Zhang, Li-Ying Cui, Zheng-Yu Jin, Yi-Cheng Zhu
BACKGROUND AND PURPOSE: Epidemiological data of cerebral small vessel disease (CSVD) in the general population of China are lacking. We report on the prevalence of lacunes, white matter hyperintensity (WMH), and cerebral microbleeds (CMBs) in a community-based sample in China and compare the results with those of other studies. METHODS: This was a cross-sectional analysis of the population-based Shunyi Study in China. A total of 1,211 stroke-free participants (mean age, 55...
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29886721/self-rated-health-status-and-risk-of-incident-stroke-in-0-5-million-chinese-adults-the-china-kadoorie-biobank-study
#8
Wenhong Dong, Xiong-Fei Pan, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Tangchun Wu, Zhengming Chen, An Pan, Liming Li
BACKGROUND AND PURPOSE: Self-rated health (SRH) is a consistent and strong predictor of all-cause and cardiovascular mortality in various populations. However, the associations between SRH measures and risk of first-ever or recurrent stroke were rarely explored. We thus aim to prospectively investigate the associations between SRH measures and risk of total and subtypes of stroke in Chinese population. METHODS: A total of 494,113 participants from the China Kadoorie Biobank without prior heart diseases or cancer (486,541 without stroke and 7,572 with stroke) were followed from baseline (2004 to 2008) until December 31, 2013...
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29886720/alcohol-intake-and-risk-of-ischemic-and-haemorrhagic-stroke-results-from-a-mendelian-randomisation-study
#9
Anne I Christensen, Børge G Nordestgaard, Janne S Tolstrup
BACKGROUND AND PURPOSE: To test whether alcohol intake, both observational and estimated by genetic instruments, is associated with risk of ischemic and haemorrhagic stroke. METHODS: We used data from the Copenhagen City Heart Study 1991 to 1994 and 2001 to 2003, and the Copenhagen General Population Study 2003 to 2012 (n=78,546). As measure of alcohol exposure, self-reported consumption and genetic variation in alcohol metabolizing genes (alcohol dehydrogenase ADH1B and ADH1C ) as instrumental variables were used...
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29886719/advances-in-stroke-prevention-in-2018
#10
M Edip Gurol, Jong S Kim
No abstract text is available yet for this article.
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29886718/nationwide-estimation-of-eligibility-for-endovascular-thrombectomy-based-on-the-dawn-trial
#11
Keon-Joo Lee, Beom Joon Kim, Dong-Eog Kim, Wi-Sun Ryu, Moon-Ku Han, Joon-Tae Kim, Kang-Ho Choi, Ki-Hyun Cho, Jae-Kwan Cha, Dae-Hyun Kim, Hyun-Wook Nah, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Mi-Sun Oh, Kyung-Ho Yu, Byung-Chul Lee, Keun-Sik Hong, Yong-Jin Cho, Tai Hwan Park, Kyung Bok Lee, Jun Lee, Ji Sung Lee, Juneyoung Lee, Hee-Joon Bae
No abstract text is available yet for this article.
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29886717/updates-on-prevention-of-hemorrhagic-and-lacunar-strokes
#12
Hsin-Hsi Tsai, Jong S Kim, Eric Jouvent, M Edip Gurol
Intracerebral hemorrhage (ICH) and lacunar infarction (LI) are the major acute clinical manifestations of cerebral small vessel diseases (cSVDs). Hypertensive small vessel disease, cerebral amyloid angiopathy, and hereditary causes, such as Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), constitute the three common cSVD categories. Diagnosing the underlying vascular pathology in these patients is important because the risk and types of recurrent strokes show significant differences...
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29886716/updates-on-prevention-of-cardioembolic-strokes
#13
Mehmet Akif Topcuoglu, Liping Liu, Dong-Eog Kim, M Edip Gurol
Cardiac embolism continues to be a leading etiology of ischemic strokes worldwide. Although pathologies that result in cardioembolism have not changed over the past decade, there have been significant advances in the treatment and stroke prevention methods for these conditions. Atrial fibrillation remains the prototypical cause of cardioembolic strokes. The availability of new long-term monitoring devices for atrial fibrillation detection such as insertable cardiac monitors has allowed accurate detection of this leading cause of cardioembolism...
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29886715/recent-advances-in-primary-and-secondary-prevention-of-atherosclerotic-stroke
#14
Georgios Tsivgoulis, Apostolos Safouris, Dong-Eog Kim, Andrei V Alexandrov
Atherosclerosis is a major cause of ischemic stroke that can be effectively prevented with appropriate lifestyle modifications and control of cardiovascular risk factors. Medical advances in recent years along with aggressive cardiovascular risk factor modifications have resulted in decreased recurrence rates of atherosclerotic stroke. Non-statin lipid-lowering molecules have recently shown clinical benefit and are recommended for very high-risk patients to reduce their risk of stroke. Aggressive hypertension treatment is crucial to reduce atherosclerotic stroke risk...
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29886714/susceptibility-vessel-sign-in-the-aster-trial-higher-recanalization-rate-and-more-favourable-clinical-outcome-after-first-line-stent-retriever-compared-to-contact-aspiration
#15
Romain Bourcier, Mickael Mazighi, Julien Labreuche, Robert Fahed, Raphael Blanc, Benjamin Gory, Alain Duhamel, Gaultier Marnat, Suzana Saleme, Vincent Costalat, Serge Bracard, Hubert Desal, Arturo Consoli, Michel Piotin, Bertrand Lapergue
BACKGROUND AND PURPOSE: In the Aspiration vs. Stent Retriever for Successful Revascularization (ASTER) trial, which evaluated contact aspiration (CA) versus stent retriever (SR) use as first-line technique, the impact of the susceptibility vessel sign (SVS) on magnetic resonance imaging (MRI) was studied to determine its influence on trial results. METHODS: We included patients having undergone CA or SR for M1 or M2 occlusions, who were screened by MRI with T2* gradient recalled echo...
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29886713/intracranial-large-artery-disease-of-non-atherosclerotic-origin-recent-progress-and-clinical-implications
#16
REVIEW
Oh Young Bang, Kazunori Toyoda, Juan F Arenillas, Liping Liu, Jong S Kim
Intracranial large artery disease (ILAD) is the major cause of stroke worldwide. With the application of recently introduced diagnostic techniques, the prevalence of non-atherosclerotic ILAD is expected to increase. Herein, we reviewed recent reports and summarized progress in the diagnosis and clinical impact of differentiation between ILAD of atherosclerotic and non-atherosclerotic origin. Our review of the literature suggests that more careful consideration of non-atherosclerotic causes and the application of appropriate diagnostic techniques in patients with ILAD may not only provide better results in the treatment of patients, but it may also lead to more successful clinical trials for the treatment of intracranial atherosclerosis...
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402073/ethnic-differences-in-intracranial-artery-tortuosity-a-possible-reason-for-different-locations-of-cerebral-atherosclerosis
#17
Bum Joon Kim, Kyung Mi Lee, Sung-Ho Lee, Hyug-Gi Kim, Eui Jong Kim, Sung Hyuk Heo, Dae-Il Chang, Jong S Kim
No abstract text is available yet for this article.
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402072/air-pollution-and-stroke
#18
REVIEW
Kuan Ken Lee, Mark R Miller, Anoop S V Shah
The adverse health effects of air pollution have long been recognised; however, there is less awareness that the majority of the morbidity and mortality caused by air pollution is due to its effects on the cardiovascular system. Evidence from epidemiological studies have demonstrated a strong association between air pollution and cardiovascular diseases including stroke. Although the relative risk is small at an individual level, the ubiquitous nature of exposure to air pollution means that the absolute risk at a population level is on a par with "traditional" risk factors for cardiovascular disease...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402071/sleep-disturbances-as-a-risk-factor-for-stroke
#19
REVIEW
Dae Lim Koo, Hyunwoo Nam, Robert J Thomas, Chang-Ho Yun
Sleep, a vital process of human being, is carefully orchestrated by the brain and consists of cyclic transitions between rapid eye movement (REM) and non-REM (NREM) sleep. Autonomic tranquility during NREM sleep is characterized by vagal dominance and stable breathing, providing an opportunity for the cardiovascular-neural axis to restore homeostasis, in response to use, distress or fatigue inflicted during wakefulness. Abrupt irregular swings in sympathovagal balance during REM sleep act as phasic loads on the resting cardiovascular system...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29402070/heart-failure-as-a-risk-factor-for-stroke
#20
REVIEW
Woohyeun Kim, Eung Ju Kim
Heart failure (HF) is one of the major causes of death worldwide. Despite the high incidence of stroke in patients with HF, there has been a controversy as to whether HF itself is a risk factor for stroke. Recently, there is a great deal of evidence that HF itself increases the risk of stroke. In previous studies, the benefit of warfarin for stroke prevention in patients with HF was offset by the risk of bleeding. In the era of non-vitamin K antagonist oral anticoagulants with low bleeding profiles, we can expect a more effective stroke prevention in patients with HF by selective anticoagulation...
January 2018: Journal of Stroke
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