Charlotte van Gorp, Ilse Hilligje de Lange, Matthias Hütten, Carmen López-Iglesias, Kimberly Massy, Lilian Kessels, Boris Kramer, Willine van de Wetering, Brad Spiller, George Birchenough, Wim van Gemert, Luc Zimmermann, Tim Wolfs
Disruption of the intestinal mucus barrier and intestinal epithelial endoplasmic reticulum (ER) stress contribute to necrotizing enterocolitis (NEC). Previously, we observed intestinal goblet cell loss and increased intestinal epithelial ER stress following chorioamnionitis. Here, we investigated how chorioamnionitis affects goblet cells by assessing their cellular characteristics. Importantly, goblet cell features are compared with those in clinical NEC biopsies. Mucus thickness was assessed as read-out of goblet cell function...
December 28, 2022: Tissue Barriers