journal
MENU ▼
Read by QxMD icon Read
search

Tissue Barriers

journal
https://www.readbyqxmd.com/read/27583195/claudin-based-barrier-differentiation-in-the-colonic-epithelial-crypt-niche-involves-hopx-klf4-and-tcf7l2-hnf4-%C3%AE-cascades
#1
Loukia N Lili, Attila E Farkas, Christian Gerner-Smidt, Christian E Overgaard, Carlos S Moreno, Charles A Parkos, Christopher T Capaldo, Asma Nusrat
Colonic enterocytes form a rapidly renewing epithelium and barrier to luminal antigens. During renewal, coordinated expression of the claudin family of genes is vital to maintain the epithelial barrier. Disruption of this process contributes to barrier compromise and mucosal inflammatory diseases. However, little is known about the regulation of this critical aspect of epithelial cell differentiation. In order to identify claudin regulatory factors we utilized high-throughput gene microarrays and correlation analyses...
July 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27583194/intestinal-barrier-analysis-by-assessment-of-mucins-tight-junctions-and-%C3%AE-defensins-in-healthy-c57bl-6j-and-balb-cj-mice
#2
Valentina Volynets, Andreas Rings, Gyöngyi Bárdos, Maureen J Ostaff, Jan Wehkamp, Stephan C Bischoff
The intestinal barrier is gaining increasing attention because it is related to intestinal homeostasis and disease. Different parameters have been used in the past to assess intestinal barrier functions in experimental studies; however most of them are poorly defined in healthy mice. Here, we compared a number of barrier markers in healthy mice, established normal values and correlations. In 48 mice (24 C57BL/6J, 24 BALB/cJ background), we measured mucus thickness, and expression of mucin-2, α-defensin-1 and -4, zonula occludens-1, occludin, junctional adhesion molecule-A, claudin-1, 2 and -5...
July 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27583193/il-1%C3%AE-mediates-cellular-cross-talk-in-the-airway-epithelial-mesenchymal-trophic-unit
#3
Alison R Hill, Jessica E Donaldson, Cornelia Blume, Natalie Smithers, Liku Tezera, Kamran Tariq, Patrick Dennison, Hitasha Rupani, Matthew J Edwards, Peter H Howarth, Christopher Grainge, Donna E Davies, Emily J Swindle
The bronchial epithelium and underlying fibroblasts form an epithelial mesenchymal trophic unit (EMTU) which controls the airway microenvironment. We hypothesized that cell-cell communication within the EMTU propagates and amplifies the innate immune response to respiratory viral infections. EMTU co-culture models incorporating polarized (16HBE14o-) or differentiated primary human bronchial epithelial cells (HBECs) and fibroblasts were challenged with double-stranded RNA (dsRNA) or rhinovirus. In the polarized EMTU model, dsRNA affected ionic but not macromolecular permeability or cell viability...
July 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27583192/control-of-cell-mechanics-by-rhoa-and-calcium-fluxes-during-epithelial-scattering
#4
REVIEW
Hillary J Haws, Melissa A McNeil, Marc D H Hansen
Epithelial tissues use adherens junctions to maintain tight interactions and coordinate cellular activities. Adherens junctions are remodeled during epithelial morphogenesis, including instances of epithelial-mesenchymal transition, or EMT, wherein individual cells detach from the tissue and migrate as individual cells. EMT has been recapitulated by growth factor induction of epithelial scattering in cell culture. In culture systems, cells undergo a highly reproducible series of cell morphology changes, most notably cell spreading followed by cellular compaction and cell migration...
July 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27583191/indomethacin-induces-increase-in-gastric-epithelial-tight-junction-permeability-via-redistribution-of-occludin-and-activation-of-p38-mapk-in-mkn-28-cells
#5
Meghali Thakre-Nighot, Anthony T Blikslager
Tight Junctions (TJ) create a paracellular barrier that is compromised when nonsteriodal anti-inflammatory drugs (NSAIDs) injure the gastric epithelium, leading to increased permeability. However, the mechanism of NSAID-induced gastric injury is unclear. Here, we examined the effect of indomethacin on barrier function and TJ in gastric MKN-28 cells. In concentration response studies, 500 µm indomethacin induced a significant decrease in transepithelial resistance (TER; 380 vs. 220 Ω·cm(2) for control and indomethacin-treated cells respectively, p < 0...
July 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27583190/multiple-roles-for-keratin-intermediate-filaments-in-the-regulation-of-epithelial-barrier-function-and-apico-basal-polarity
#6
REVIEW
Pedro J Salas, Radia Forteza, Anastasia Mashukova
As multicellular organisms evolved a family of cytoskeletal proteins, the keratins (types I and II) expressed in epithelial cells diversified in more than 20 genes in vertebrates. There is no question that keratin filaments confer mechanical stiffness to cells. However, such a number of genes can hardly be explained by evolutionary advantages in mechanical features. The use of transgenic mouse models has revealed unexpected functional relationships between keratin intermediate filaments and intracellular signaling...
July 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27583189/role-of-autophagy-in-the-regulation-of-epithelial-cell-junctions
#7
REVIEW
Prashant Nighot, Thomas Ma
Autophagy is a cell survival mechanism by which bulk cytoplasmic material, including soluble macromolecules and organelles, is targeted for lysosomal degradation. The role of autophagy in diverse cellular processes such as metabolic stress, neurodegeneration, cancer, aging, immunity, and inflammatory diseases is being increasingly recognized. Epithelial cell junctions play an integral role in the cell homeostasis via physical binding, regulating paracellular pathways, integrating extracellular cues into intracellular signaling, and cell-cell communication...
July 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27583188/current-trends-in-salivary-gland-tight-junctions
#8
REVIEW
Olga J Baker
Tight junctions form a continuous intercellular barrier between epithelial cells that is required to separate tissue spaces and regulate selective movement of solutes across the epithelium. They are composed of strands containing integral membrane proteins (e.g., claudins, occludin and tricellulin, junctional adhesion molecules and the coxsackie adenovirus receptor). These proteins are anchored to the cytoskeleton via scaffolding proteins such as ZO-1 and ZO-2. In salivary glands, tight junctions are involved in polarized saliva secretion and barrier maintenance between the extracellular environment and the glandular lumen...
July 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27583187/human-immunodeficiency-virus-associated-disruption-of-mucosal-barriers-and-its-role-in-hiv-transmission-and-pathogenesis-of-hiv-aids-disease
#9
REVIEW
Sharof Tugizov
Oral, intestinal and genital mucosal epithelia have a barrier function to prevent paracellular penetration by viral, bacterial and other pathogens, including human immunodeficiency virus (HIV). HIV can overcome these barriers by disrupting the tight and adherens junctions of mucosal epithelia. HIV-associated disruption of epithelial junctions may also facilitate paracellular penetration and dissemination of other viral pathogens. This review focuses on possible molecular mechanisms of HIV-associated disruption of mucosal epithelial junctions and its role in HIV transmission and pathogenesis of HIV and acquired immune deficiency syndrome (AIDS)...
July 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27358759/introduction-for-the-special-issue-on-recent-advances-in-drug-delivery-across-tissue-barriers
#10
Randall J Mrsny, David J Brayden
This special issue of Tissue Barriers contains a series of reviews with the common theme of how biological barriers established at epithelial tissues limit the uptake of macromolecular therapeutics. By improving our functional understanding of these barriers, the majority of the authors have highlighted potential strategies that might be applied to the non-invasive delivery of biopharmaceuticals that would otherwise require an injection format for administration. Half of the articles focus on the potential of particular technologies to assist oral delivery of peptides, proteins and other macromolecules...
April 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27358758/erratum
#11
(no author information available yet)
[This corrects the article DOI: 10.1080/21688370.2016.1142493.].
April 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27358757/cell-penetrating-peptides-as-tools-to-enhance-non-injectable-delivery-of-biopharmaceuticals
#12
REVIEW
Mie Kristensen, Hanne Mørck Nielsen
Non-injectable delivery of peptide and protein drugs is hampered by their labile nature, hydrophilicity, and large molecular size; thus limiting their permeation across mucosae, which represent major biochemical and physical barriers to drugs administered via e.g. the oral, nasal, and pulmonary routes. However, in recent years cell-penetrating peptides (CPP) have emerged as promising tools to enhance mucosal delivery of co-administered or conjugated peptide and protein cargo and more advanced CPP-cargo formulations are emerging...
April 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27358756/safety-concerns-over-the-use-of-intestinal-permeation-enhancers-a-mini-review
#13
REVIEW
Fiona McCartney, John P Gleeson, David J Brayden
Intestinal permeation enhancers (PEs) are key components in ∼12 oral peptide formulations in clinical trials for a range of molecules, primarily insulin and glucagon-like-peptide 1 (GLP-1) analogs. The main PEs comprise medium chain fatty acid-based systems (sodium caprate, sodium caprylate, and N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC)), bile salts, acyl carnitines, and EDTA. Their mechanism of action is complex with subtle differences between the different molecules. With the exception of SNAC and EDTA, most PEs fluidize the plasma membrane causing plasma membrane perturbation, as well as enzymatic and intracellular mediator changes that lead to alteration of intestinal epithelial tight junction protein expression...
April 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27358755/poly-amido-amine-dendrimers-in-oral-delivery
#14
REVIEW
Venkata K Yellepeddi, Hamidreza Ghandehari
Poly(amidoamine) (PAMAM) dendrimers have been extensively investigated for oral delivery applications due to their ability to translocate across the gastrointestinal epithelium. In this Review, we highlight recent advances in the evaluation of PAMAM dendrimers as oral drug delivery carriers. Specifically, toxicity, mechanisms of transepithelial transport, models of the intestinal epithelial barrier including isolated human intestinal tissue model, detection of dendrimers, and surface modification are discussed...
April 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27358754/chemically-modified-peptides-and-proteins-critical-considerations-for-oral-delivery
#15
REVIEW
Stephen T Buckley, František Hubálek, Ulrik Lytt Rahbek
Numerous approaches have been explored to date in the pursuit of delivering peptides or proteins via the oral route. One such example is chemical modification, whereby the native structure of a peptide or protein is tailored to provide a more efficient uptake across the epithelial barrier of the gastrointestinal tract via incorporation of a chemical motif or moiety. In this regard, a diverse array of concepts have been reported, ranging from the exploitation of endogenous transport mechanisms to incorporation of physicochemical modifications in the molecule, which promote more favorable interactions with the absorptive membrane at the cell surface...
April 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27358753/tissue-barriers-and-novel-approaches-to-achieve-hepatoselectivity-of-subcutaneously-injected-insulin-therapeutics
#16
REVIEW
Juntang Shao, Jennica L Zaro, Wei-Chiang Shen
Current subcutaneously (s.c.)-injected insulin (INS) products result in a hyperinsulin exposure to peripheral tissues (skeletal muscle and adipose) while INS hardly accesses to liver after injection. This unphysiological distribution raises risks of hypoglycemia episode and causes weight gain after long term treatment. An ideal INS replacement therapy requires the distribution or action of exogenous INS to more closely mimic physiological INS in terms of its preferential hepatic action. However, there are 2 factors that limit the ability of s...
April 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27358752/of-microneedles-and-ultrasound-physical-modes-of-gastrointestinal-macromolecule-delivery
#17
REVIEW
Carl M Schoellhammer, Robert Langer, Giovanni Traverso
No abstract text is available yet for this article.
April 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27358751/plant-derived-edible-nanoparticles-as-a-new-therapeutic-approach-against-diseases
#18
REVIEW
Mingzhen Zhang, Emilie Viennois, Changlong Xu, Didier Merlin
In plant cells, nanoparticles containing miRNA, bioactive lipids and proteins serve as extracellular messengers to mediate cell-cell communication in a manner similar to the exosomes secreted by mammalian cells. Notably, such nanoparticles are edible. Moreover, given the proper origin and cargo, plant derived edible nanoparticles could function in interspecies communication and may serve as natural therapeutics against a variety of diseases. In addition, nanoparticles made of plant-derived lipids may be used to efficiently deliver specific drugs...
April 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27141428/introduction-for-the-special-issue-on-the-blood-brain-barrier
#19
Inge S Zuhorn
No abstract text is available yet for this article.
January 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27141427/junctional-proteins-of-the-blood-brain-barrier-new-insights-into-function-and-dysfunction
#20
REVIEW
Svetlana M Stamatovic, Allison M Johnson, Richard F Keep, Anuska V Andjelkovic
The blood-brain barrier (BBB) is a highly complex and dynamic barrier. It is formed by an interdependent network of brain capillary endothelial cells, endowed with barrier properties, and perivascular cells (astrocytes and pericytes) responsible for inducing and maintaining those properties. One of the primary properties of the BBB is a strict regulation of paracellular permeability due to the presence of junctional complexes (tight, adherens and gap junctions) between the endothelial cells. Alterations in junction assembly and function significantly affect BBB properties, particularly barrier permeability...
January 2016: Tissue Barriers
journal
journal
47856
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"