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Medical Mycology Case Reports

John L Kiley, Jason Zack, Simon Ritchie, Kevin Krauland, Elizabeth Markelz
Patients with toxic epidermal necrolysis, a condition that causes full thickness epidermal necrosis that affects over 30% of the skin surface and mucosal membranes, often develop comorbid infections throughout the recovery of the disease [1]. While most commonly these are related to a bacterial source, infections due to viral, mycobacterial, and rarely fungal organisms occur. We present a case of a patient who developed a deep cutaneous fungal infection caused by Trichosporon asahii and discuss the management...
March 2019: Medical Mycology Case Reports
John Burston, Mark Robertson, Sebastian van Hal, Angie N Pinto
No abstract text is available yet for this article.
March 2019: Medical Mycology Case Reports
Mustafa Fadhel, Swapnil Patel, Edward Liu, Michael Levitt, Arif Asif
Saccharomyces cerevisiae has recently been used as an ingredient in probiotic supplements. Invasive Saccharomyces infection have been documented, and multiple predisposing risk factors have been identified including critical illness, ICU admission, antibiotics use, central venous catheters, probiotics use, and immunosuppression. We report a case of a 74-year-old man admitted for acute cholangitis taking a probiotic supplement containing the subtype Saccharomyces boulardii. He later developed S. cerevisiae fungemia that was successfully treated with Micafungin and Fluconazole...
March 2019: Medical Mycology Case Reports
Ruth Tunney, Kirsty Rodger, David W Denning, Chris Kosmidis
Chronic pulmonary aspergillosis (CPA) is predominantly found alongside cavitating or bullous lung diseases. Although pulmonary embolism may cause cavitation, an association with CPA has not been well described. We describe a case of CPA in a 79-year-old female following bilateral pulmonary emboli. The clinical implications are numerous, including the dilemma of anticoagulation. This link suggests that a lower threshold for suspecting CPA following pulmonary embolus is required, even in the absence of other respiratory disease...
March 2019: Medical Mycology Case Reports
Walter A Eyer-Silva, Marcelo Costa Velho Mendes de Azevedo, Guilherme Almeida Rosa da Silva, Rodrigo Panno Basílio-de-Oliveira, Luciana Ferreira de Araujo, Isabela Vieira do Lago, Franciele Cristina Ferreira Pereira, Miriã Boaretto Teixeira Fernandes, Maria Helena Galdino Figueiredo-Carvalho, Vanessa Brito de Souza Rabello, Rosely Maria Zancopé-Oliveira, Rodrigo de Almeida-Paes, Fernando Raphael de Almeida Ferry, Rogério Neves-Motta
Sporotrichosis is a human and animal disease caused by dimorphic pathogenic species of the genus Sporothrix . We report a dramatic presentation of Sporothrix brasiliensis infection, with destruction of the nasal septum, soft palate, and uvula of an HIV-infected woman. She was successfully treated with amphotericin B deoxycholate followed by itraconazole. Sporotrichosis remains a neglected opportunistic infection in patients with AIDS and awareness of this potentially fatal infection is of utmost importance.
March 2019: Medical Mycology Case Reports
Ana María Garcia-Giraldo, Barbara Lucia Mora, Jorge Mario Loaiza-Castaño, Jorge Andrés Cedano, Fernando Rosso
Invasive aspergillosis usually affects immunocompromised hosts with variable manifestations depending on the site of infection. In this article, we present two cases of invasive Aspergillosis in two non-immunocompromised patients; both cases had a paranasal sinuses infection, with intraorbital and intracranial extension, requiring surgery and antifungal treatment with Voriconazole. These cases were initially diagnosed as paranasal sinus neoplasms. However, the pathology and microbiology studies revealed invasive fungal infection by Aspergillus flavus ...
March 2019: Medical Mycology Case Reports
Clarisse Máximo Arpini, Yhuri Cardoso Nóbrega, Vinícius Davel Castheloge, Daniel Santos Neves, Carlos Eduardo Tadokoro, Gisela Lara da Costa, Manoel Marques Evangelista Oliveira, Marcelo Renan de Deus Santos
This paper reports a case of Purpureocillium lilacinum infection in seven loggerhead sea turtle ( Caretta caretta ) hatchlings kept in an aquarium under inadequate condition. The fungus was isolated from skin and pulmonary lesions. Metilene blue and NaCl solutions, Schinus terebinthifolius and eucalyptus essential oils Minimum Inhibitory Concentrations were determined indicating new possibilities for treatment.
March 2019: Medical Mycology Case Reports
Fatehi Elzein, Kiran Kalam, Nazik Mohammed, Ahmed Elzein, Fadhel Zaben Alotaibi, Mujtaba Khan, Abeer Albadani
We report on an elderly male patient with headache and right-side weakness. Imaging studies revealed multiple space-occupying lesions in the parietal and occipital cerebral regions. Biopsy revealed broad aseptate ribbon-like structures branching at right angles, suggestive of mucormycosis. Improvement was observed after medical therapy with 20 weeks of liposomal amphotericin B (5 mg/kg/day) combined with posaconazole, followed by posaconazole (400 mg twice a day) alone for 1 month. The patient recovered without neurological deficits; however, multidrug-resistant bacteraemia and hospital-acquired pneumonia occurred, resulting in death...
March 2019: Medical Mycology Case Reports
Timothy J Hatlen, Scott G Filler, Arnold Bayer, Sonia Shah, Shivani Shodhan, Tam T Van
Fungal endocarditis remains an uncommon clinical diagnosis, though is likely to become more frequent due to the global increase in transplantations and cardiac valvular surgery. A case of prosthetic valve endocarditis due to Aspergillus fumigatus is described that was diagnosed with serologic fungal markers and confirmed with positive blood cultures, an uncommon finding.
March 2019: Medical Mycology Case Reports
Ruchika Bagga, Vijay Kumar Chattu
Invasive fungal infections are a leading cause of morbidity and mortality in the immunocompromised patients. We report a case of Triadelphia pulvinata , a rare dematiaceous fungi causing invasive fungal infection in a 68 year old diabetic Iraqi female. The diagnosis was made by combining the phenotypic findings and genome sequencing. There are only 4 case reports in literature and this is probably the first from India which was treated by Liposomal Amphotericin B.
December 2018: Medical Mycology Case Reports
Raymond M Wilson, Nyambura Moremi, Martha F Mushi, Oliver Bader, Patrick S Ngoya, Bernard M Desderius, Peter Rambau, Rodrick Kabangila, Uwe Groß, Stephen E Mshana
We report a case of disseminated cryptococcosis in a 42-year old immunocompetent female. Prior to admission at Bugando Medical Center, the patient was attended at three hospitals for hypertension and clinically diagnosed malaria. Following diagnosis of disseminated Cryptococcus at our center, she was successfully treated with fluconazole but remained with visual loss. Blood cultures should be considered in the management of any adult presenting with fever to enable early detection of the least expected differentials like in this case...
December 2018: Medical Mycology Case Reports
Peter F Bennett, Jessica J Talbot, Patricia Martin, Sarah E Kidd, Mariano Makara, Vanessa R Barrs
Canine disseminated fungal infection by Aspergillus species carries a guarded to grave prognosis as they often rapidly progress and are refractory to treatment with many euthanased soon after diagnosis. This case report describes a 2.5 year old female spayed German Shepherd Dog diagnosed with disseminated Aspergillus deflectus infection for which definitive treatment was declined by the owners. With only palliative management the dog survived three years and two months before succumbing to chronic kidney disease...
December 2018: Medical Mycology Case Reports
Taher Sabobeh, Kamran Mushtaq, Ahmed Elsotouhy, Adham A Ammar, Sameera Rashid
Immunocompromised status is associated with invasive fungal infections including mucormycosis. These infections are challenging to treat and associated with high overall mortality. Here we report a fatal case of invasive mucormycosis in a cirrhotic, diabetic patient. Despite the swift diagnosis and management; the fungal invasion of the right internal carotid artery lead to massive ischemic stroke. Timely diagnosis and management is crucial for management but it seems not always enough and new approaches for treatment must be sought...
December 2018: Medical Mycology Case Reports
Laura Trovato, Maria Domina, Ada Vancheri, Salvatore Oliveri, Nicola Ciancio
Several cases have been reported of B. capitatus infections in immunocompromised patients. Acute leukemia is the main predisposing factor. Chronic lymphocytic leukemia (CLL) is not usually associated with opportunistic infections. We report a case of pulmonary infection by B. capitatus in a patient with untreated chronic lymphocytic leukemia. Although the patient had a complete recovery, we believe that this report will alert clinicians to consider B. capitatus as possible cause of severe pneumonia in untreated CLL...
December 2018: Medical Mycology Case Reports
Tina Marinelli, Sarah Kidd, David Shaw, Emily Rowe
Aspergillus endocarditis is rare with most cases occurring in immunosuppressed patients. We present the case of an "immunocompetent" Indigenous Australian male with culture confirmed Aspergillus brain abscesses complicating bilateral endocarditis. The reported mortality rate for Aspergillus endocarditis approaches 100%. Despite sub-optimal therapy this patient survived beyond expectation.
December 2018: Medical Mycology Case Reports
Pongpratch Puapatanakul, Nuttha Lumlertgul, Nisa Thongbor, Jidapa Mahamongkholsawat, Talerngsak Kanjanabuch
As peritoneal dialysis (PD)-related fungal infection is associated with a high mortality rate, the international guidelines recommend immediate removal of the PD catheter in conjunction with at least 2-weeks of antifungal treatment. Some authors have reported successful management of such cases without removing the PD catheter - by instilling an antifungal lock into the retained PD catheter. However, the use of antifungal locks has generally not been well accepted as the standard treatment for fungal peritonitis in PD patients...
December 2018: Medical Mycology Case Reports
Peggy Vieille, Rodrigo Cruz, Paula León, Nicolás Cáceres, Gustavo Giusiano
Hereby we communicate the first autochthon isolation of Cryptococcus gattii VGIII in Chile, which was obtained from a nasal injury in a domestic cat in the Valparaíso region in Chile. The strain was identified using morphophysiological tests, MALDI-TOF, and URA5 gene PCR-RFLP analysis.
December 2018: Medical Mycology Case Reports
McKenna E Boyd, Harry Dao, Jerry D Estep, Yve T Huttenbach, Vagish Hemmige
We report the use of voriconazole troughs to achieve appropriate therapeutic levels in treatment of a cutaneous Scedosporium apiospermum infection. Following heart transplantation, a 63-year-old immunocompromised patient presented with post-traumatic nodular lesions on his right shin. Pathology showed fungal yeasts with culture revealing Scedosporium apiospermum. According to therapeutic drug monitoring, initial voriconazole treatment was subtherapeutic requiring increased dosing until appropriate therapeutic trough levels were attained, and resolution of the fungal infection was achieved...
December 2018: Medical Mycology Case Reports
José Antonio Vargas Soler, William Javier Morales Camacho, Claudia Ximena Flórez Rodríguez, Johana Andrea Navarro Mejía, Carlos Fernando Guerrero, María Alejandra Morales Camacho
Fungal endocarditis (FE) is a rare infection in pediatrics which accounts for 5% of the cases of infective endocarditis. This pathology affects immunosuppressed patients in a greater proportion. We present an immunocompetent 7- year-old female with a history of multiple cardiac surgeries who developed fungal endocarditis due to Aspergillus flavus . The histology study showed liquefactive necrosis and septate hyphae of Aspergillus sp type. The clinical outcome was favorable and the ambulatory follow-up after 12 months showed no new complications...
December 2018: Medical Mycology Case Reports
Stephanie Egge, Eric Wei, Erin Clements, Andrew Stevenson Joel Chandranesan
Mucorales infections typically occur in immunocompromised hosts. We describe a case of disseminated post-traumatic Apophysomyces elegans in an immunocompetent patient status-post soil inoculation. Fungi introduced at a deep arm laceration leads to neurovascular invasion and dissemination prior to amputation and systemic treatment. We specify strict post-traumatic wound surveillance protocol and roles of novel tissue tests to improve time to diagnosis and prognosis of frequently fatal post-traumatic Mucorales infections...
December 2018: Medical Mycology Case Reports
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