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Medical Mycology Case Reports

Gabriel J Echeverri, Luis-Armando Caicedo, Alejandro Delgado, Laura-Sofia Thomas, Victor H Garcia, Catalina Gomez, Ana M Aristizabal, Ana M Arrunátegui, Fernando Rosso
We present the first cirrhotic patient who underwent liver transplantation (LT) and presented a hepatic artery thrombosis of the graft due to Aspergillus fumigatu s, within the first month of LT. This culminated in graft loss, re-transplant with multiple biliary and infectious complications. To our knowledge, this is a case report of an early hepatic artery thrombosis due to Aspergillus fumigatus in an infection-free patient.
December 2018: Medical Mycology Case Reports
Maricela Valerio, Marina Machado, Santiago Cedeño, Maria Luisa Rodríguez, Fernando Anaya, Antonio Vena, Jesús Guinea, Pilar Escribano, Emilio Bouza, Patricia Muñoz
The risk of transmission of infectious diseases from allograft to recipient is well known. Viruses and bacteria are the most frequent causes of transmissible infections. Donor-derived invasive aspergillosis is rare and occurred under particular circumstances. We report 2 cases of kidney transplant recipients who acquired aspergillosis from a single donor.
December 2018: Medical Mycology Case Reports
Ayaka Tashiro, Takahito Nei, Ryoji Sugimoto, Akiko Watanabe, Jun Hagiwara, Toru Takiguchi, Hiroyuki Yokota, Katsuhiko Kamei
Kodamaea ohmeri is a relatively rare yeast isolated form clinical specimens, and it is known to be a causative fungus of severe invasive infectious diseases in immunocompromised hosts. Herein, we describe fungemia due to K. ohmeri in a patient with a severe extended burn. The isolate was obtained from not only blood specimens but also skin lesions. We should be aware of risk for fungemia including K. ohmeri in case of severe burn.
December 2018: Medical Mycology Case Reports
Tjomme van der Bruggen, Anna Kolecka, Bart Theelen, Johanna M Kwakkel-van Erp, Bert Arets, Teun Boekhout
Cystic fibrosis (CF) patients are colonized with a multitude of bacteria and fungi. From respiratory samples of two CF patients in our institute, a difficult to identify yeast was isolated repeatedly. This yeast was eventually identified as Cutaneotrichosporon ( Cryptococcus ) cyanovorans by internal transcribed spacer (ITS) and ribosomal large subunit (LSU) sequencing. C. cyanovorans is a basidiomycetous yeast originally reported as environmental isolate from South African soil and has not been described before as clinical isolate from CF patients...
December 2018: Medical Mycology Case Reports
Simon Arunga, Teddy Kwaga, Astrid Leck, Victor H Hu, Matthew J Burton
A 35-year-old male presented with Candida keratitis in the left eye. He was HIV positive with a CD4 of 352 cells/µL. The eye quickly deteriorated, despite intensive antifungal treatment and was eviscerated. Five months later, he re-presented with Candida keratitis in his right eye. A focal source of Candida infection was suspected and a urine culture identified Candida spp, despite being asymptomatic for genitourinary candidiasis. He was subsequently treated with good outcome (max. 75 words).
December 2018: Medical Mycology Case Reports
Felix Bongomin, Isabel Rodriguez-Goncer, Carol Lorden, Akaninyene Otu, Rohit Bazaz
Antifungal agents account for approximately 3% of Drug-Induced Liver Injury (DILI) cases. Isavuconazole is a novel triazole, and experience with long-term use of it is lacking. We report a case of late-onset DILI occurring after 11 months of isavuconazole therapy in a 55-year old man of Angolan descent on long-term antifungal therapy for the management of chronic pulmonary aspergillosis complicating previously treated pulmonary tuberculosis. The DILI could be described as idiosyncratic as it was not associated with high isavuconazole serum levels and his liver function tests returned to normal following treatment discontinuation...
December 2018: Medical Mycology Case Reports
Iker Falces-Romero, Emilio Cendejas-Bueno, María Laplaza-González, Luis Escosa-García, Cristina Schuffelmann-Gutiérrez, Belén Calderón-Llopis, Javier Pemán, Pedro de la Oliva, Julio García-Rodríguez
A case of 1-year- old male multivisceral transplant recipient with candidemia diagnosed by the T2Candida® test is presented. Optimal management of the candidemia complemented the treatment of the global clinical episode. Duration of treatment might be established much more precisely with the T2Candida® test than with blood cultures.
September 2018: Medical Mycology Case Reports
Jennifer L Anderson, Matthew C Hall, Jennifer K Meece
Asymptomatic blastomycosis infections are rarely identified or described in the literature, but are believed to comprise 50% of cases. In this report we describe five sporadic cases of blastomycosis in asymptomatic patients. All of these cases were initially identified as incidental findings of lung nodules on CXR or CT. To our knowledge, these are the first detailed descriptions of asymptomatic blastomycosis, occurring as sporadic disease, in the literature.
September 2018: Medical Mycology Case Reports
Isabel Rodriguez-Goncer, Felix Bongomin, Helen M Doran, Lily Novak-Frazer, Rikesh Masania, Caroline B Moore, Malcolm D Richardson
We report a case of Cryptococcus gattii infection in the UK in a 76-year-old woman on biologic therapy for intra-abdominal non-Hodgkin lymphoma. An incidental nodular lung lesion was found on a chest imaging and histology, culture and molecular mycology studies of the lobectomy specimen revealed the presence of C. gattii .
September 2018: Medical Mycology Case Reports
Eric Y Chang, Shaheen Fatima, Shuba Balan, Kshama Bhyravabhotla, Marc Erickson, Austin Chan, Chinedu Ivonye, Cinnamon Bradley
Candida dubliniensis infections are rare in the absence of prolonged immunocompromised status or intravenous drug abuse. We present a case of a C. dubliniensis soft tissue abscess in a patient with uncontrolled diabetes as his only immunocompromising risk factor, treated with surgical drainage and medical management.
September 2018: Medical Mycology Case Reports
Walaiporn Wangchinda, Piriyaporn Chongtrakool, Jantima Tanboon, Anupop Jitmuang
Lomentospora prolificans is a rare cause of vertebral osteomyelitis. We report a case of L. prolificans thoracic vertebral osteomyelitis with spinal epidural abscess in a patient without apparent immunodeficiency. Clinical manifestations and radiographic findings could not distinguish from other etiologic agents. Treatment is also challenging because L. prolificans is usually resistant to antifungal agents. The patient underwent surgical debridement and has been receiving a prolonged combination of antifungal therapy to prevent an infection relapse...
September 2018: Medical Mycology Case Reports
Merad Yassine, Adjmi-Hamoudi Haiet
Ear self-mutilation have been reported in schizophrenia, Mechanical damages to the auditory canal, like cleaning ear with hard and unsterile objects are predisposing factors of otomycosis. We present a case of repeated self-induced auricular trauma in schizophrenic patient. Aural swab were collected and examined by direct microscopy and culture, revealing Aspergillus flavus . A traumatized external ear canal skin can present favourable condition for fungal growth in the psychiatric population.
September 2018: Medical Mycology Case Reports
A P P Teh, T Hirai, S Ito, Y Hidaka, Y Goto, H Furukawa, J Sawada, R Yamaguchi
A 7-month-old female Japanese Black calf developed elongated, nodular mass measuring 30 × 16 cm extended from the retropharyngeal region to mid lateral neck region. Histological examination revealed granulomatous lymphangitis with non-septate fungal hyphae recognized throughout the lesions. Fungal culture, DNA sequencing and molecular phylogenetic tree analysis confirmed the sequence of Lichtheimia corymbifera . The lymphogenous route was speculated to be the main route of fungal spread leading to the characteristic nodular appearance of this case...
September 2018: Medical Mycology Case Reports
Blenda Fernandes, Rachel Basques Caligiorne, Dayana Monteiro Coutinho, Renata R Gomes, Fabiana Rocha-Silva, Amanda Sanchez Machado, Emanoelle Fernandes Rutren La Santrer, Claudia Barbosa Assunção, Cássio Ferreira Guimarães, Maria Silvia Laborne, Mauricio Buzelin Nunes, Vania A Vicente, Sybren de Hoog
This paper presents a case of disseminated sporotrichosis in a 13-year-old female, originating from a rural area in Minas Gerais state, Brazil. The patient was hospitalized in Santa Casa hospital of Belo Horizonte, with hyporexia, prostration, fever and disseminated ulcerative lesions, besides anemia, leucopenia and sepsis of probable cutaneous focus. The patient was admitted without proven immunosuppression. She was diagnosed with cutaneous-disseminated sporotrichosis. The drug therapy chosen was itraconazole during 12 months, leading to important clinical improvement and healing of cutaneous lesions...
September 2018: Medical Mycology Case Reports
Maddalena Iannaccone, Petra Rita Basso, Terenzio Congiu, Paolo Cavicchio, Valentina Ulivi, Marco Campolo
A young female Aldabra giant tortoise ( Adabrachelys gigantea ) was presented with anorexia, ataxia, severe constipation and bloating. Analysis revealed liver disease and collected biopsy diagnosed Candida krusei infection. Despite Itraconazole treatment, the tortoise got worse and died. Full necropsy was performed; microbiology showed Candida krusei presence in liver, but histopathology didn't confirm fungal presence with special stains, so scanning electron microscopy was essential to prove a detailed diagnosis of extensive mycosis...
September 2018: Medical Mycology Case Reports
Ciara O'Connor, Ciaran Farrell, Aurelie Fabre, Donna Eaton, Karen Redmond, David G McSharry, John B Conneely, Conor J Shields, Jim J Egan, Margaret M Hannan
Invasive fungal infections in immunosuppressed transplant patients are associated with significant morbidity and mortality. We present a case of splenic mucormycosis post-double lung transplant, presenting as uncontrolled near-fatal upper gastrointestinal haemorrhage, to remind clinicians of the need to consider pre-transplant invasive fungal infection risk factors if an unexpected fungal infection arises in the post-transplant period. This case also highlights the valuable contribution of molecular technology for fungal identification but also the need for clinical correlation...
September 2018: Medical Mycology Case Reports
Alexis Guenette, Shahid Husain, Ana Konvalinka, William Geddie, Coleman Rotstein
There are limited data on blastomycosis in solid organ transplant recipients with the subsequent development of the immune reconstitution inflammatory syndrome (IRIS). Herein we describe a case of pulmonary blastomycosis in a renal transplant recipient with the development of concomitant IRIS.
September 2018: Medical Mycology Case Reports
Maria Nina Chitasombat, Porkaew Petchkum, Suthas Horsirimanont, Pattana Sornmayura, Ariya Chindamporn, Theerapong Krajaejun
Vascular Pythiosis caused by Pythium insiodiosum rarely involves carotid artery. A case of concealed ruptured pseudoaneurysm of the carotid artery with neck abscesses, and cerebral septic emboli is described. Patient presented with large pulsatile neck mass that failed to response to surgery, antifungals and immunotherapeutic vaccine. Residual unresectable disease leads to death in the patient. Pythiosis should be considered as a differential diagnosis of head and neck infection.
September 2018: Medical Mycology Case Reports
Shukla Das, Richa Tigga, Gargi Rai, Praveen Kumar Singh, Shyama Datt, Asha Tyagi, Narendra Pal Singh
Candida auris has become a great challenge in diagnostic, therapeutic and hospital environmental adaptation. With a prevalence of 5.3% in intensive care unit (ICU) acquired candidemia in India, its colonization is very rapid which hastens hospital transmission. Strict surveillance and preventive measures need to be adopted in ICU as it can persist on dry, inanimate object, prompt adaptation and antifungal resistance can pose a future threat of a new drug hospital acquired pathogen.
September 2018: Medical Mycology Case Reports
Jessica D Workum, Suzanne W de Jong, Mark S Gresnigt, Katharina L Becker, Peter Pickkers, Frank L van de Veerdonk, Yvonne F Heijdra, Eva Kolwijck
Invasive pulmonary aspergillosis is increasingly described in non-neutropenic patients, such as patients with COPD receiving corticosteroids and the critically ill. Here, we present a case of a lethal pulmonary Aspergillus niger infection in a COPD patient. Immunological tests showed an impaired innate and adaptive immune response to Aspergillus . A history of COPD, unresponsiveness to antibiotics and especially a suggestive CT-scan should trigger the clinician to consider diseases caused by Aspergillus.
September 2018: Medical Mycology Case Reports
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