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Medical Mycology Case Reports

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https://www.readbyqxmd.com/read/29348997/diagnosis-and-management-of-a-fatal-case-of-sepsis-caused-by-candida-parapsilosis-sensu-stricto-in-a-neonate-with-omphalocele
#1
Simone Santana, Tania Salci, Patricia Andriato, Patricia Bonfim-Mendonça, Silvana Caparroz-Assef, Melyssa Negri, Terezinha Svidzinski
We present a fatal case of persistent neonatal candidemia by Candida parapsilosis following omphalocele, without other anomalies. Despite an encouraging initial prognosis, after surgical correction and closure of the abdominal wall the case became difficult to treat, as in addition to the exposure of the patient to multiple risk factors for candidemia, antifungal therapy apparently was not adequate.
June 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29264110/successful-treatment-of-breakthrough-disseminated-trichosporon-asahii-fungemia-in-a-patient-with-acute-myeloid-leukemia-receiving-itraconazole-prophylaxis
#2
Daiki Karigane, Masatoshi Sakurai, Emiko Matsuyama, Kentaro Ide, Sakiko Yamamoto-Takeuchi, Toyoko Inazumi, Sumiko Kohashi
We encountered a case of a 73-year-old man with acute myeloid leukemia who developed Trichosporon asahii systemic infection while on itraconazole prophylaxis during severe neutropenia. Cryptococcal antigen was useful for diagnosis. Although itraconazole was ineffective in protecting against trichosporonosis, treatment was successful with voriconazole following liposomal amphotericin B.
June 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29379706/histoplasmosis-an-oral-malignancy-like-clinical-picture
#3
Tomasz Chroboczek, Julie Dufour, Alain Renaux, Christine Aznar, Magalie Demar, Pierre Couppie, Antoine Adenis
HIV-associated histoplasmosis is mainly misdiagnosed for granulomatous diseases, such as tuberculosis. Nonetheless, malignancy-like lesions have been reported sporadically in HIV-infected patients. Although the main reported lesions are erosive or ulcerated, here a rare case of oral tumor is reported. This case raises the awareness of this presentation, and the importance of accurate identification in the laboratory. Performing systematic specific stains for fungal elements and culture on tissue samples ensures accurate differential diagnosis...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29379705/the-important-role-of-co-infections-in-patients-with-aids-and-progressive-disseminated-histoplasmosis-pdh-a-cohort-from-colombia
#4
Diego H Caceres, Ángela M Tobón, Ángela Restrepo, Tom Chiller, Beatriz L Gómez
A total of 23/45 (51%) patients with AIDS and histoplasmosis from Medellín, Colombia had other infections. Tuberculosis was the most common (n = 16/23, 70%). Pneumocystosis and cryptococcosis were found in three patients each (13%), bacterial infection and cytomegalovirus occurred each in two patients (9%) while toxoplasmosis, herpes virus and esophageal candidiasis were recorded in one patient each (4%). Of all co-infected patients, 18/23 (78%) had one, four (17%) had two and one (4%) had three additional opportunistic infections...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29379704/paradoxical-respiratory-failure-due-to-cryptococcal-pneumonia-after-amphotericin-b-treatment-for-hiv-associated-cryptococcal-meningitis
#5
James E Scriven, Francois Cj Botha, Charlotte Schutz, David G Lalloo, Helen Wainwright, Graeme Meintjes
We present a 27-year-old lady with HIV-1 infection who died due to rapidly worsening respiratory failure one day after commencing amphotericin B deoxycholate therapy for cryptococcal meningitis. Chest x-ray appearances were consistent with pneumocystis pneumonia but post mortem examination showed evidence of severe necrotizing cryptococcal pneumonia. Cryptococcal pneumonia is an underrecognized condition and should be considered in the differential of patients with HIV-1 infection and low CD4 count who develop respiratory symptoms...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29379703/clinical-features-of-three-patients-with-paradoxical-immune-reconstitution-inflammatory-syndrome-associated-with-talaromyces-marneffei-infection
#6
Nguyen Tat Thanh, Le Duc Vinh, Nguyen Thanh Liem, Cecilia Shikuma, Jeremy N Day, Guy Thwaites, Thuy Le
Talaromyces marneffei infection is a major cause of death in HIV-infected individuals in South and Southeast Asia. Talaromycosis immune reconstitution inflammatory syndrome has not been well described. Here we report the clinical features, management, and outcomes of three HIV-infected patients with talaromycosis-associated paradoxical immune reconstitution inflammatory syndrome in Ho Chi Minh City, Vietnam.
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29234588/emerging-fluconazole-resistance-implications-for-the-management-of-cryptococcal-meningitis
#7
Edward Mpoza, Joshua Rhein, Mahsa Abassi
We present the case of an HIV-seropositive individual with cryptococcal meningitis who was found to have a fluconazole resistant strain of Cryptococcus neoformans. The individual required multiple rounds of amphotericin and fluconazole 800-1200 mg after several episodes of clinical relapse. Cerebrospinal fluid sterilization was achieved and maintained with high doses of fluconazole. This case demonstrates the emerging dilemma of increasing rates of fluconazole resistance in Cryptococcus and the clinical difficulties in meningitis management...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29234587/pulmonary-papillary-adenocarcinoma-with-aspergillus-versicolor-infection-in-a-dog
#8
Rathiymaler Maniam, Gayathri Thevi Selvarajah, Mazlina Mazlan, Leslie Thian Lung Than
Papillary adenocarcinoma of the lungs is the most common primary lung adenocarcinoma, with the feature of papillary-like structure formation by cells. A dog was presented with the primary complaint of vomiting, hyporexia and increased respiratory effort. Thoracic radiography revealed increased soft tissue radiopacity of the right cranial lung lobe suggestive of possible consolidation or collapsed lung lobe, with generalised miliary nodular pattern throughout the other lung fields. The dog was euthanized humanely and necropsy was performed...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29234586/aspergillus-tamarii-keratitis-in-a-contact-lens-wearer
#9
Juan Cuadros, Juan Gros-Otero, Patricia Gallego-Angui, Ann Karolin Scheu, Ángeles Montes-Mollón, Cinta Pérez-Rico, Javier Paz Moreno, Peña Gómez-Herruz, Juan Soliveri, Miguel Teus
Keratitis produced by Aspergillus tamarii has been previously described associated to an ocular injury. We report a case in a contact lens wearer with a history of previous bilateral myopic LASIK ablation, bilateral intracorneal rings and vitrectomy and scleral buckling in his left eye. The fungus could be quickly identified combining phenotype, microscopy and mass spectrometry. Treatment with intravenous amphotericin, oral voriconazole, and topical amphotericin and natamycin and voriconazole was needed for corneal preservation...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29204336/sporotrichosis-by-sporothrix-schenckii-senso-stricto-with-itraconazole-resistance-and-terbinafine-sensitivity-observed-in-vitro-and-in-vivo-case-report
#10
Rodrigo Vettorato, Daiane Heidrich, Fernanda Fraga, Amanda Carvalho Ribeiro, Danielle Machado Pagani, Carina Timotheo, Tais Guarienti Amaro, Gerson Vettorato, Maria Lúcia Scroferneker
We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29188178/tumor-shape-pulmonary-mucormycosis-associated-with-sinonasal-aspergillosis-in-a-diabetic-patient
#11
Sophie Point, Frédéric Gabriel, Hugues Bégueret, Jacques Jougon, Fanny Lanternier, Frédéric Grenouillet, Manal Abdel Fattah, Emilie Catherinot, Chantal Raherison, Elodie Blanchard
Mucormycosis is a rare and life-threatening fungal infection of the Mucorales order occurring mainly in immunosuppressed patients. The most common forms are rhinocerebral but pulmonary or disseminated forms may occur. We report the case of a 61-year-old patient in whom pulmonary mucormycosis was diagnosed during his first-ever episode of diabetic ketoacidosis. While receiving liposomal amphotericin B, a sinusal aspergillosis due to Aspergillus fumigatus occurred. Evolution was slowly favorable under antifungal tritherapy by liposomal amphotericin B, posaconazole and caspofungin...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29159027/a-case-of-paracoccidioidomycosis-due-to-paracoccidioides-lutzii-presenting-sarcoid-like-form
#12
Luiza Sarmento Tatagiba, Luana Bridi Pivatto, Álvaro A Faccini-Martínez, Paulo Mendes Peçanha, Tânia Regina Grão Velloso, Sarah Santos Gonçalves, Anderson Messias Rodrigues, Zoilo Pires Camargo, Aloísio Falqueto
Paracoccidioidomycosis (PCM) is a fungal disease caused by Paracoccidioides spp., which can cause a systemic granulomatous infection with tegumentary and visceral involvement. Sarcoid-like skin lesions are uncommon and can be misdiagnosed due to similarities with other granulomatous diseases. We report a case of a women presenting with erythematous infiltrated plaques on her face that was treated for leprosy and rosacea with no response and was later diagnosed with PCM, presenting positive serology for Paracoccidioides lutzii...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29071205/disseminated-paracoccidioidomycosis-prediagnosticated-as-neoplasm-an-important-challenge-in-diagnosis-using-rt-pcr
#13
Fabiana Rocha-Silva, Cássio Ferreira Guimarães, Edmundo Rocha de Oliveira Júnior, Sônia Maria de Figueiredo, Rachel Basques Caligiorne
This paper presents a case of disseminated paracoccidioidomycosis in a 62-year-old male patient, who lives in Belo Horizonte, MG, Brazil. The patient was hospitalized with icteric syndrome of cholestatic pattern and weight loss, with loss 30 kg in 5 months. The imaging of the abdomen showed lesion of infiltrative pattern, affecting gallbladder and intrahepatic bile ducts, suggesting neoplasia of malignant behavior, besides to presenting the yellow nail syndrome. Dermatological examination presented erythematous-infiltrated plaques in the occipital region...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29034160/eosinophilic-plasmacytic-conjunctivitis-concurrent-with-gingival-fistula-caused-by-schizophyllum-commune-in-a-captive-cheetah-acinonyx-jubatus
#14
Madoka Yoshizawa, Shinpei Kawarai, Yoshiko Torii, Kaori Ota, Kiyoshi Tasaka, Kazuko Nishimura, Chieko Fujii, Nobuyuki Kanemaki
We describe for the first time the diagnosis of Schizophyllum commune infection in a captive cheetah. Eosinophilic plasmacytic conjunctivitis was detected histopathologically in a biopsy specimen. Both a second surgical specimen and drainage fluid from a gingival mass and fistula contained fungal hyphae in giant cells with granulomatous inflammation. Allergic S. commune mycosis was suspected at this point. A monokaryotic isolate was characterized morphologically, and then identified genetically. Treatment with itraconazole and pimaricin was effective...
December 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28970974/pediatric-gastrointestinal-basidiobolomycosis-mimicking-malignancy
#15
Zainab Almoosa, Mohammed Alsuhaibani, Sadeq AlDandan, Dayel Alshahrani
Basidiobolomycosis is a rare fungal infection with high prevalence in southwestern province of Saudi Arabia (Tohama region); it mainly causes subcutaneous infections and rarely gastrointestinal disease. Because of its indolent presentation, it is often misdiagnosed as IBD, tuberculosis or Malignancy. We are reporting a 7 year old Saudi girl with abdominal mass, fever and eosinophilia resembling malignancy on radiological and pathological picture fully recovered with only medical therapy in the form of oral Voriconazole 2012 Elsevier Ltd...
December 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28808616/periprosthetic-hip-joint-infection-with-aspergillus-terreus-a-clinical-case-and-a-review-of-the-literature
#16
Rachel Bartash, Yi Guo, John B Pope, Michael H Levi, Wendy Szymczak, Nidhi Saraiya, Priya Nori
Fungal periprosthetic joint infections due to Aspergillus species are rare but are associated with significant cost and morbidity. We present a case of Asperigillus terreus prosthetic joint infection of the hip. The patient was successfully treated with a prolonged course of systemic antifungals along with surgical management.
December 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28794961/feline-cutaneous-histoplasmosis-the-first-case-report-from-thailand
#17
L Larsuprom, L Duangkaew, C Kasorndorkbua, C Chen, A Chindamporn, N Worasilchai
A 2-year-old, neutered female domestic shorthaired cat presented with a history of multiple papules and nodules on pinnae, nodules on the nose, and chronic wound at the lateral surface of left radial area for four months. Skin biopsy demonstrated moderate numbers of small, oval-to-round, single-walled yeasts inside the macrophages. In addition, PCR confirmed the sequence of Histoplasma capsulatum. This is the first case report of feline cutaneous histoplasmosis in Thailand.
December 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28794960/gastric-perforation-after-duodenopancreatectomy
#18
Henrik Bäcker, Frank Jp Beeres, Marco Rossi, Andreas Scheiwiller
Fungal and bacterial infections are often which may cause sepsis. Mucormycosis is an unfrequent, but often life-threatening disease. A timely diagnosis and treatment is the cornerstone of success. An increase in incidence can be expected, given an aging population and increasing incidence of obesity, diabetes and cancer. We present a rare case where early diagnosis has helped to treat the patient mainly with antifungal therapy as surgical therapy has had high risk of complications.
December 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28794959/cutaneous-lesions-due-to-trichosporon-jirovecii-in-a-tortoise-testudo-hermanni
#19
Simona Nardoni, Marco Salvadori, Alessandro Poli, Guido Rocchigiani, Francesca Mancianti
Cutaneous mycoses have been rarely reported in Chelonians. A Testudo hermanni adult male showed a thick erosion of the dorsal neck covered by necrotic material. Trichosporon sp. was cultivated, while arthrospores and hyphae were observed in histological sections. The causative agent was identified as Trichosporon jirovecii by PCR. After a surgical intervention povidone iodine and Iruxol® ointment were daily administered through the drainage for 2 weeks, along with enrofloxacin 5 mg diluted in saline 0.5 ml via the intracelomatic route...
December 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28794958/saccharomyces-cerevisiae-var-boulardii-fungemia-following-probiotic-treatment
#20
Marcelo C Appel-da-Silva, Gabriel A Narvaez, Leandro R R Perez, Laura Drehmer, Jairo Lewgoy
Probiotics are commonly prescribed as an adjuvant in the treatment of antibiotic-associated diarrhea caused by Clostridium difficile. We report the case of an immunocompromised 73-year-old patient on chemotherapy who developed Saccharomyces cerevisiae var. boulardii fungemia in a central venous catheter during treatment of antibiotic-associated pseudomembranous colitis with the probiotic Saccharomyces cerevisiae var. boulardii. Fungemia was resolved after interruption of probiotic administration without the need to replace the central venous line...
December 2017: Medical Mycology Case Reports
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