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Medical Mycology Case Reports

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https://www.readbyqxmd.com/read/29755935/aspergillus-endocarditis-of-the-mitral-valve-with-ventricular-myocardial-invasion-cerebral-vasculitis-and-intracranial-mycotic-aneurysm-formation-in-a-patient-with-hemophagocytic-lymphohistiocytosis
#1
Bibin Varghese, Kevin Ting, Juan Lopez-Mattei, Cezar Iliescu, Joseph Kim, Peter Kim
Aspergillus endocarditis is a rare infection and reported mainly in immunocompromised hosts. We report a case of mitral valve aspergillus endocarditis with ventricular myocardial invasion, cerebral vasculitis and intracranial fungal aneurysm formation in a patient with hemophagocytic lymphohistiocytosis (HLH). This case illustrates the importance of prompt investigation and treatment of masses seen on an echocardiogram for rare infections such as Aspergillus endocarditis in immunocompromised patients.
September 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29560305/invasive-pulmonary-mucormycosis-and-aspergillosis-in-a-patient-with-decompensated-hepatic-cirrhosis
#2
Jon G Persichino, Argun D Can, Tam T Van, Michele N Matthews, Scott G Filler
Invasive pulmonary mucormycosis and aspergillosis are rare, life-threatening fungal infections. Most documented cases have been reported in non-cirrhotic patients with diabetes mellitus, neutropenia, or treatment with corticosteroids. The prevalence of each infection is low among patients with hepatic cirrhosis. We report the first likely case of combined invasive pulmonary mucormycosis and aspergillosis in a male with decompensated hepatic cirrhosis. This report also highlights the first non-diabetic case of invasive pulmonary mucormycosis with decompensated hepatic cirrhosis...
September 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29560304/two-cases-of-fungal-keratitis-caused-by-metarhizium-anisopliae
#3
Abigail L Goodman, Shawn R Lockhart, Colleen B Lysen, Lars F Westblade, Carey-Ann D Burnham, Eileen M Burd
We present two cases of keratitis due to Metarhizium anisopliae in geographically separated areas of the United States. The isolates were microscopically similar but morphologically different and were identified by ribosomal DNA sequencing. Both isolates had low minimum inhibitory concentration (MIC) values to caspofungin and micafungin, but high MIC values to amphotericin B. The morphologic and antifungal susceptibility differences between the two isolates indicate possible polyphylogeny of the group.
September 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29556453/subcutaneous-abscesses-caused-by-trichophyton-rubrum-in-the-unilateral-groin-of-an-immunocompromised-patient-a-case-report
#4
Utako Okata-Karigane, Yasuki Hata, Emiko Watanabe-Okada, Shunichi Miyakawa, Michi Ota, Yutaka Uzawa, Shigekazu Iguchi, Atsushi Yoshida, Ken Kikuchi
A 60-year-old Japanese man presented with multiple subcutaneous nodules in his left groin. Histologically, the nodules consisted of suppurative granulomas and abscesses not involving the hair follicles. Trichophyton rubrum TWCC57922 was detected by fungal culture and polymerase chain reaction (PCR) sequencing of the rDNA genes. We diagnosed these nodules as deeper dermal dermatophytosis, a rare form of invasive dermatophytosis. He was treated with terbinafine. We compared these findings with previous reports of deep dermal dermatophytosis...
September 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29657917/hemophagocytic-lymphohistiocytosis-hlh-secondary-to-disseminated-histoplasmosis-in-the-setting-of-acquired-immunodeficiency-syndrome-aids
#5
Samuel Asanad, Brendan Cerk, Veronica Ramirez
Hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease involving immune system over-activation leading to hemophagocytosis. HLH requires early diagnosis and prompt treatment initiation, especially in patients with Acquired Immunodeficiency Syndrome (AIDS). We present a case of a middle-aged male with AIDS and renal failure, who developed HLH secondary to disseminated histoplasmosis. Etoposide chemotherapy as recommended by the HLH 2004 Guidelines was deferred and treatment focused instead on anti-fungal therapy...
June 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29552460/acute-fulminant-invasive-pulmonary-aspergillosis-in-an-immunocompetent-host-an-autopsy-case-report
#6
Yuuki Ohara, Takahiko Ito, Makoto Ito, Kyoko Yamashita, Shinya Toyokuni
A 62-year-old previously healthy male who was a welder/smoker/drinker was admitted to Kani Tono Hospital for severe hypoxemia (Day 0). Initial physical and radiological examinations suggested an acute exacerbation of chronic obstructive pulmonary disease. However, respiratory failure developed rapidly, and he died on Day + 4. Aspergillus fumigatus was identified after his death, and he was diagnosed with invasive pulmonary aspergillosis. The clinical and pathological features are precisely described with pathogenetic considerations...
June 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29552459/differential-distribution-patterns-of-fonsecaea-agents-of-chromoblastomycosis-exemplified-by-the-first-case-due-to-f-monophora-from-argentina
#7
Marcelo Label, Luciana C Karayan, Sybren De Hoog, Javier Afeltra, Togo Bustamante, Roxana G Vitale
Chromoblastomycosis is a mutilating infection of the skin and subcutaneous tissues caused by melanized fungi belonging to the order Chaetothyriales. Proven cases of the main agent, Fonsecaea pedrosoi are mainly limited to (sub)tropical, humid climates of Latin and Central America and the Caribbean. Fonsecaea monophora has a global distribution along the equator. Cases outside the (sub)tropics have thus far mostly been considered to have been imported, but here we report the first endemic case by F. monophora from Argentina...
June 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29487779/late-presentation-of-pneumocystis-jirovecii-pneumonia-after-renal-transplant-a-case-report
#8
Prithiv Prasad, Kevin Bryan Lo, Pradhum Ram
The highest risk of opportunistic infections is from 1 to 6 months post-transplant. We report a rare case of Pneumocystis jirovecii pneumonia in a renal transplant recipient only on maintenance immunosuppression eleven years after transplant without concomitant CMV infection or recent episodes of graft rejection.
June 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29348997/diagnosis-and-management-of-a-fatal-case-of-sepsis-caused-by-candida-parapsilosis-sensu-stricto-in-a-neonate-with-omphalocele
#9
Simone Santana, Tania Salci, Patricia Andriato, Patricia Bonfim-Mendonça, Silvana Caparroz-Assef, Melyssa Negri, Terezinha Svidzinski
We present a fatal case of persistent neonatal candidemia by Candida parapsilosis following omphalocele, without other anomalies. Despite an encouraging initial prognosis, after surgical correction and closure of the abdominal wall the case became difficult to treat, as in addition to the exposure of the patient to multiple risk factors for candidemia, antifungal therapy apparently was not adequate.
June 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29264110/successful-treatment-of-breakthrough-disseminated-trichosporon-asahii-fungemia-in-a-patient-with-acute-myeloid-leukemia-receiving-itraconazole-prophylaxis
#10
Daiki Karigane, Masatoshi Sakurai, Emiko Matsuyama, Kentaro Ide, Sakiko Yamamoto-Takeuchi, Toyoko Inazumi, Sumiko Kohashi
We encountered a case of a 73-year-old man with acute myeloid leukemia who developed Trichosporon asahii systemic infection while on itraconazole prophylaxis during severe neutropenia. Cryptococcal antigen was useful for diagnosis. Although itraconazole was ineffective in protecting against trichosporonosis, treatment was successful with voriconazole following liposomal amphotericin B.
June 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29379706/histoplasmosis-an-oral-malignancy-like-clinical-picture
#11
Tomasz Chroboczek, Julie Dufour, Alain Renaux, Christine Aznar, Magalie Demar, Pierre Couppie, Antoine Adenis
HIV-associated histoplasmosis is mainly misdiagnosed for granulomatous diseases, such as tuberculosis. Nonetheless, malignancy-like lesions have been reported sporadically in HIV-infected patients. Although the main reported lesions are erosive or ulcerated, here a rare case of oral tumor is reported. This case raises the awareness of this presentation, and the importance of accurate identification in the laboratory. Performing systematic specific stains for fungal elements and culture on tissue samples ensures accurate differential diagnosis...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29379705/the-important-role-of-co-infections-in-patients-with-aids-and-progressive-disseminated-histoplasmosis-pdh-a-cohort-from-colombia
#12
Diego H Caceres, Ángela M Tobón, Ángela Restrepo, Tom Chiller, Beatriz L Gómez
A total of 23/45 (51%) patients with AIDS and histoplasmosis from Medellín, Colombia had other infections. Tuberculosis was the most common (n = 16/23, 70%). Pneumocystosis and cryptococcosis were found in three patients each (13%), bacterial infection and cytomegalovirus occurred each in two patients (9%) while toxoplasmosis, herpes virus and esophageal candidiasis were recorded in one patient each (4%). Of all co-infected patients, 18/23 (78%) had one, four (17%) had two and one (4%) had three additional opportunistic infections...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29379704/paradoxical-respiratory-failure-due-to-cryptococcal-pneumonia-after-amphotericin-b-treatment-for-hiv-associated-cryptococcal-meningitis
#13
James E Scriven, Francois Cj Botha, Charlotte Schutz, David G Lalloo, Helen Wainwright, Graeme Meintjes
We present a 27-year-old lady with HIV-1 infection who died due to rapidly worsening respiratory failure one day after commencing amphotericin B deoxycholate therapy for cryptococcal meningitis. Chest x-ray appearances were consistent with pneumocystis pneumonia but post mortem examination showed evidence of severe necrotizing cryptococcal pneumonia. Cryptococcal pneumonia is an underrecognized condition and should be considered in the differential of patients with HIV-1 infection and low CD4 count who develop respiratory symptoms...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29379703/clinical-features-of-three-patients-with-paradoxical-immune-reconstitution-inflammatory-syndrome-associated-with-talaromyces-marneffei-infection
#14
Nguyen Tat Thanh, Le Duc Vinh, Nguyen Thanh Liem, Cecilia Shikuma, Jeremy N Day, Guy Thwaites, Thuy Le
Talaromyces marneffei infection is a major cause of death in HIV-infected individuals in South and Southeast Asia. Talaromycosis immune reconstitution inflammatory syndrome has not been well described. Here we report the clinical features, management, and outcomes of three HIV-infected patients with talaromycosis-associated paradoxical immune reconstitution inflammatory syndrome in Ho Chi Minh City, Vietnam.
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29234588/emerging-fluconazole-resistance-implications-for-the-management-of-cryptococcal-meningitis
#15
Edward Mpoza, Joshua Rhein, Mahsa Abassi
We present the case of an HIV-seropositive individual with cryptococcal meningitis who was found to have a fluconazole resistant strain of Cryptococcus neoformans . The individual required multiple rounds of amphotericin and fluconazole 800-1200 mg after several episodes of clinical relapse. Cerebrospinal fluid sterilization was achieved and maintained with high doses of fluconazole. This case demonstrates the emerging dilemma of increasing rates of fluconazole resistance in Cryptococcus and the clinical difficulties in meningitis management...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29234587/pulmonary-papillary-adenocarcinoma-with-aspergillus-versicolor-infection-in-a-dog
#16
Rathiymaler Maniam, Gayathri Thevi Selvarajah, Mazlina Mazlan, Leslie Thian Lung Than
Papillary adenocarcinoma of the lungs is the most common primary lung adenocarcinoma, with the feature of papillary-like structure formation by cells. A dog was presented with the primary complaint of vomiting, hyporexia and increased respiratory effort. Thoracic radiography revealed increased soft tissue radiopacity of the right cranial lung lobe suggestive of possible consolidation or collapsed lung lobe, with generalised miliary nodular pattern throughout the other lung fields. The dog was euthanized humanely and necropsy was performed...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29234586/aspergillus-tamarii-keratitis-in-a-contact-lens-wearer
#17
Juan Cuadros, Juan Gros-Otero, Patricia Gallego-Angui, Ann Karolin Scheu, Ángeles Montes-Mollón, Cinta Pérez-Rico, Javier Paz Moreno, Peña Gómez-Herruz, Juan Soliveri, Miguel Teus
Keratitis produced by Aspergillus tamarii has been previously described associated to an ocular injury. We report a case in a contact lens wearer with a history of previous bilateral myopic LASIK ablation, bilateral intracorneal rings and vitrectomy and scleral buckling in his left eye. The fungus could be quickly identified combining phenotype, microscopy and mass spectrometry. Treatment with intravenous amphotericin, oral voriconazole, and topical amphotericin and natamycin and voriconazole was needed for corneal preservation...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29204336/sporotrichosis-by-sporothrix-schenckii-senso-stricto-with-itraconazole-resistance-and-terbinafine-sensitivity-observed-in-vitro-and-in-vivo-case-report
#18
Rodrigo Vettorato, Daiane Heidrich, Fernanda Fraga, Amanda Carvalho Ribeiro, Danielle Machado Pagani, Carina Timotheo, Tais Guarienti Amaro, Gerson Vettorato, Maria Lúcia Scroferneker
We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29188178/tumor-shape-pulmonary-mucormycosis-associated-with-sinonasal-aspergillosis-in-a-diabetic-patient
#19
Sophie Point, Frédéric Gabriel, Hugues Bégueret, Jacques Jougon, Fanny Lanternier, Frédéric Grenouillet, Manal Abdel Fattah, Emilie Catherinot, Chantal Raherison, Elodie Blanchard
Mucormycosis is a rare and life-threatening fungal infection of the Mucorales order occurring mainly in immunosuppressed patients. The most common forms are rhinocerebral but pulmonary or disseminated forms may occur. We report the case of a 61-year-old patient in whom pulmonary mucormycosis was diagnosed during his first-ever episode of diabetic ketoacidosis. While receiving liposomal amphotericin B, a sinusal aspergillosis due to Aspergillus fumigatus occurred. Evolution was slowly favorable under antifungal tritherapy by liposomal amphotericin B, posaconazole and caspofungin...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29159027/a-case-of-paracoccidioidomycosis-due-to-paracoccidioides-lutzii-presenting-sarcoid-like-form
#20
Luiza Sarmento Tatagiba, Luana Bridi Pivatto, Álvaro A Faccini-Martínez, Paulo Mendes Peçanha, Tânia Regina Grão Velloso, Sarah Santos Gonçalves, Anderson Messias Rodrigues, Zoilo Pires Camargo, Aloísio Falqueto
Paracoccidioidomycosis (PCM) is a fungal disease caused by Paracoccidioides spp., which can cause a systemic granulomatous infection with tegumentary and visceral involvement. Sarcoid-like skin lesions are uncommon and can be misdiagnosed due to similarities with other granulomatous diseases. We report a case of a women presenting with erythematous infiltrated plaques on her face that was treated for leprosy and rosacea with no response and was later diagnosed with PCM, presenting positive serology for Paracoccidioides lutzii...
March 2018: Medical Mycology Case Reports
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