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Medical Mycology Case Reports

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https://www.readbyqxmd.com/read/28491490/rapid-emergence-of-fks-mutations-in-candida-glabrata-isolates-in-a-peritoneal-candidiasis
#1
Milène Sasso, Claire Roger, Laurence Lachaud
We report a rapid acquisition of echinocandin resistance after 12 days of micafungin treatment, without prior exposure, in a patient with peritoneal candidiasis due to C. glabrata. Isolates recovered before and after treatment were compared by multilocus sequence typing. Results of antifungal susceptibility testing and FKS mutations were reported. The interest of repeating antifungal susceptibility testing for echinocandin molecules during the treatment is discussed and a strategy to research FKS mutations proposed...
June 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28458993/chromoblastomycosis-caused-by-rhinocladiella-similis-case-report
#2
Daiane Heidrich, Gloria M González, Danielle M Pagani, Mauricio Ramírez-Castrillón, Maria Lucia Scroferneker
We report a case of chromoblastomycosis in lesions on the chest and foot. Itraconazole was chosen as the initial treatment for this patient, who was followed up for 8 months before becoming noncompliant. The pathogenic fungal species was identified as Rhinocladiella similis by ITS region sequencing. In vitro analyses indicate that the fungus was sensitive to posaconazole and itraconazole. This report presents R. similis as a new agent of chromoblastomycosis and raises the hypothesis that this species could be more resistant to some antifungals than R...
June 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28417063/melanized-fungus-as-an-epidural-abscess-a-diagnostic-and-therapeutic-challenge
#3
Adesh Shrivastava, Karuna Tadepalli, Garima Goel, Kajal Gupta, Pradeep Kumar Gupta
Curvularia a dematiaceous fungus is ubiquitously found in soil around the world. We report an epidural abscess due to Curvularia lunata in a 48 years male farmer who underwent decompressive laminectomy as primary modality of treatment followed by isolation, identification and confirmation of the isolate from tissue by ITS sequencing. Antifungal therapy with voriconazole and amphotericin B for 3 and 2 weeks respectively improved patient's condition and is presently on regular follow up with no sequelae since last 7 months...
June 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28409094/successful-treatment-of-azole-resistant-invasive-aspergillosis-in-a-bottlenose-dolphin-with-high-dose-posaconazole
#4
Paulien E Bunskoek, Seyedmojtaba Seyedmousavi, Steven J M Gans, Peter B J van Vierzen, Willem J G Melchers, Cornelis E van Elk, Johan W Mouton, Paul E Verweij
Invasive aspergillosis due to azole-resistant Aspergillus fumigatus is difficult to manage. We describe a case of azole-resistant invasive aspergillosis in a female bottlenose dolphin, who failed to respond to voriconazole and posaconazole therapy. As intravenous therapy was precluded, high dose posaconazole was initiated aimed at achieving trough levels exceeding 3 mg/l. Posaconazole serum levels of 3-9.5 mg/l were achieved without significant side-effects. Follow-up bronchoscopy and computed tomography showed complete resolution of the lesions...
June 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28409093/first-case-of-invasive-magnusiomyces-capitatus-infection-in-slovakia
#5
Dominika Tanuskova, Julia Horakova, Peter Svec, Ivana Bodova, Martina Lengerova, Matej Bezdicek, Miroslava Poczova, Jozef Koppl, Alexandra Kolenova
Magnusiomyces capitatus (previously known as Geotrichum capitatum or Blastoschizomyces capitatus or Trichosporon capitatum) is a rare cause of fungal infection in immunocompromised patients. Most of these cases (87%) have been reported from the Mediterranean region, as it is extremely rare to recognize it in other regions. Here we report a first case of disseminated M. capitatus infection in Slovakia. The patient - 19 year old woman with myelodysplastic syndrome was diagnosed with M. capitatus fungemia after allogeneic stem cell transplantation...
June 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28386527/coccidioidal-meningitis-complicated-by-central-nervous-system-vasculitis-in-a-patient-with-leukemia
#6
Dany Tager, Anne Hatch, Jennifer Segar, Brentin Roller, Mayar Al Mohajer, Tirdad T Zangeneh
Central Nervous System (CNS) vasculitis is the most common life-threatening complication of coccidioidal meningitis. It is manifested by cerebral ischemia, hemorrhage, and infarction. We report a case of CNS vasculitis in a patient receiving chemotherapy and review of the literature on coccidioidal meningitis. The patient was treated with combination antifungal therapy and a short course of high dose corticosteroids with a modest improvement in her neurological examination after initiation of steroids.
June 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28386526/kmucormicosys-due-to-saksenaea-vasiformis-in-a-dog
#7
Francisco J Reynaldi, Gabriela Giacoboni, Susana B Córdoba, Julián Romero, Enso H Reinoso, Ruben Abrantes
A 2-year-old female Border collie was examined for dermatitis with a partial alopecic zone around her left front member. Six months later the lesion became swollen, alopecic with ulcerated areas. Microscopy analysis of samples showed numerous non-septate, branching, thin-walled and irregular shaped hyphal elements. Fungal cultures and molecular studies identified Saksenaea vasiformis. Treatments with griseofulvin, itraconazole and surgical debridement were used, however, fourteen months later the dog was euthanatized because of the unfavorable clinical outcome...
June 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28377868/a-case-of-breakthrough-candida-parapsilosis-fungemia-during-micafungin-therapy-for-a-candida-glabrata-bloodstream-infection
#8
Yuta Norimatsu, Daiichi Morii, Asako Kogure, Taeko Hamanaka, Yoshihiro Kuwano, Takayuki Yokozawa, Toshimi Oda
We describe a case of breakthrough Candida parapsilosis fungemia in an 80-year-old woman with pyoderma gangrenosum and rheumatoid arthritis. C. parapsilosis was detected in blood culture while the patient was treated with micafungin for a Candida glabrata bloodstream infection. The breakthrough infection was successfully treated with liposomal amphotericin B.
June 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28280685/catheter-related-saccharomyces-cerevisiae-fungemia-following-saccharomyces-boulardii-probiotic-treatment-in-a-child-in-intensive-care-unit-and-review-of-the-literature
#9
Serkan Atıcı, Ahmet Soysal, Kıvılcım Karadeniz Cerit, Şerife Yılmaz, Burak Aksu, Gürsu Kıyan, Mustafa Bakır
Although Saccharomyces boulardii is usually a non-pathogenic fungus, in rare occasions it can cause invasive infection in children. We present the case of an 8-year-old patient in pediatric surgical intensive care unit who developed S. cerevisiae fungemia following probiotic treatment containing S. boulardii. Caspofungin was not effective in this case and he was treated with amphotericin B. We want to emphasize that physicians should be careful about probiotic usage in critically ill patients.
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28275534/disseminated-phaeohyphomycosis-in-a-dog
#10
Lana S Rothenburg, Timothy A Snider, Allison Wilson, Anthony W Confer, Akhilesh Ramachandran, Rinosh Mani, Theresa Rizzi, Laura Nafe
Phaeohyphomycosis is a rare but emerging disease caused by dematiaceous fungi. Here we describe the case of an immunosuppressed dog with disseminated phaeohyphomycosis secondary to Bipolaris spicifera infection. Regionally extensive infiltration of the paw pads, skin, myocardium, liver, renal interstitium and diaphragm was identified on histopathology. Candida glabrata and Fusarium oxysporum were also cultured from multiple sites post-mortem. The dog was treated with fluconazole, itraconazole, terbinafine and liposomal amphotericin B, but was euthanized due to its poor prognosis after 12 days of therapy...
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28217436/the-first-report-of-onychomycosis-caused-by-cryptococcus-friedmannii-naganishia-friedmannii-a-basidiomycetous-yeast
#11
Masoome Ekhtiari, Shirin Farahyar, Mehraban Falahati, Elham Razmjou, Mahtab Ashrafi-Khozani, Zeinab Ghasemi, Ziba Abbasi-Nejat
Yeasts are common etiologic agents of onychomycosis. This study reported a case of onychomycosis due to Cryptococcus friedmannii (Naganishia friedmannii). This yeast was isolated of the right great toenail of 57-year-old man. Microscopic examination of nail scrapings showed budding cells with thin capsule. Sequence analyzes of the internal transcribed spacer regions was closely related to Cryptococcus friedmannii. The results of susceptibility testing showed the Cryptococcus friedmannii to be sensitive to fluconazole, itraconazole and amphotericin B...
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28217435/a-rare-fungal-infection-phaehyphomycosis-due-to-veronaea-botryosa-and-review-of-literature
#12
Anne Welfringer, Valérie Vuong, Nicolas Argy, Christian Chochillon, Lydia Deschamps, Guillaume Rollin, Stanislas Harent, Véronique Joly, William Vindrios, Vincent Descamps
We report a rare case of phaehyphomycosis in a 71-year-old heart transplant recipient Togo native patient. Four months after the transplant, he presented painless nodules on the right heel with superficial ulceration. The polyphasic identification uncovered a rare cause of phaehyphomycose: V. botryosa. The treatment combined surgical excision of the lesions and anti-fungal therapy with posaconazole. We discussed eleven reported cases in literature since 1990.
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28180057/cutaneous-alternariosis-in-a-renal-transplant-patient-successfully-treated-with-posaconazole-case-report-and-literature-review
#13
Rajinder Bajwa, Amy L Wojciechowski, Chiu-Bin Hsiao
Cutaneous alternariosis is an uncommon fungal infection that most commonly presents in organ transplant patients on immunosuppressive therapy. There are no clinical trials or guidelines to guide treatment of this condition, however itraconazole is the most commonly used antifungal in published cases. Here we report on a case of cutaneous alternariosis in a renal transplant recipient treated with a newer antifungal, posaconazole. A review of published reports of cutaneous alternariosis since 2008 is also discussed...
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28116230/cutaneous-blastomycosis-and-dermatophytic-pseudomycetoma-in-a-persian-cat-from-bangkok-thailand
#14
Lerpen Duangkaew, Lawan Larsuprom, Chaiyan Kasondorkbua, Charles Chen, Ariya Chindamporn
This is a case report of concurrent of blastomycosis and pseudomycetoma in a 3 year-old Persian cat from Bangkok, Thailand. Histopathology from antemortem and postmortem samples revealed blastomycosis and dermatophyte pseudomycetoma. The PCR analysis of the formalin-embedded tissue of antemortem sample confirmed that blastomycosis was caused by Blastomyces dermatitidis. Dermatophyte infection was caused by Microsporum canis. According to the author's knowledge, this is the first case of Blastomyces dermatitidis and dermatophyte pseudomycetoma in South-East Asia...
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28053852/allergic-bronchopulmonary-mycosis-caused-by-penicillium-luteum
#15
Chiyako Oshikata, Maiko Watanabe, Akemi Saito, Hiroshi Yasueda, Kazuo Akiyama, Yoichi Kamata, Naomi Tsurikisawa
A 65-year-old Japanese male had severe bronchial asthma had increased mold-containing sputum. Serum total IgE level had increased to 798 IU/mL and antigen-specific precipitating antibodies to P. luteum and P. notatum were present but not those reactive toward any species of Aspergillus. Chest computed tomography revealed central bronchiectasis and bronchial wall thickness. After antigen-specific provocation with 10 mg/mL of P. luteum, the patient developed asthma exacerbation, but not with A. fumigatus. We present a rare case of Penicillium-induced allergic bronchopulmonary mycosis caused by P...
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28053851/verruconis-gallopava-cardiac-and-endovascular-infection-with-dissemination-after-renal-transplantation-case-report-and-lessons-learned
#16
Zoe Jennings, Kathy Kable, Catriona L Halliday, Brian J Nankivell, Jen Kok, Germaine Wong, Sharon C-A Chen
Verruconis gallopava is an uncommon cause of phaeohyphomycosis. We describe an unusual case of disseminated V. gallopava infection in a renal transplant recipient involving the endocardium but without endocarditis, associated with fungaemia and infection in the skin, oral cavity, brain and lung. The isolate was first detected from blood cultures which is rare. Surgical resection of cardiac fungal mass was not possible. The patient died despite resolution of fungaemia and combination antifungal therapy.
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28053850/disseminated-coccidioidomycosis-presenting-with-intramedullary-spinal-cord-abscesses-management-challenges
#17
Kristina L Bajema, Mark F Dalesandro, David N Fredricks, Meena Ramchandani
Coccidioides species are endemic to the southwestern United States and typically cause a mild or asymptomatic primary infection. In some instances, infection can disseminate and involve the central nervous system with meningitis being the most common manifestation. Non-osseous spinal cord involvement is exceedingly rare. We report a case of disseminated coccidioidomycosis in an otherwise healthy 20 year old man with diffuse leptomeningeal enhancement, cerebrospinal fluid findings suggestive of meningitis, and intramedullary spinal cord abscesses...
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28053849/long-term-outcome-of-medical-and-surgical-co-management-of-craniospinal-aspergillosis-in-an-immunocompromised-patient
#18
Dipu Sathyapalan, Sabarish Balachandran, Anil Kumar, Bindu Mangalath Rajamma, Ashok Pillai, Vidya P Menon
35 yr old steroid dependent lady with Pulmonary TB underwent debridement of epidural abscess & posterior stabilization for paraparesis. With histopathology and cultures showing Aspergillus fumigatus, voricanozole was started. By the fourth week, she developed persistent fever, and altered mental status. Brain MRI and CSF study including multiplex PCR evaluation confirmed cerebral aspergillosis. Voricanozole was changed to intravenous lipid complex Amphotericin B to achieve sustained clinical and radiological response after six months of therapy...
December 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28053848/rapid-development-of-a-mycotic-aneurysm-of-the-intracranial-artery-secondary-to-scedosporium-apiospermum-sinusitis
#19
Yoshihiko Ogawa, Masatoshi Sato, Masato Tashiro, Masayuki Miyazaki, Kiyoshi Nagata, Nobuyuki Takahashi, Kei Kasahara, Koichi Izumikawa, Hisakazu Yano, Keiichi Mikasa
An 85-year-old man complained of a 2-month history of pain on the left side of his face. Brain computed tomography (CT) and magnetic resonance imaging/magnetic resonance angiography did not clearly show any intracranial abnormality and only showed fluid effusion in his left sphenoid sinus. Filamentous fungi were detected from the left sphenoid sinus specimen. The isolate was Scedosporium apiospermum. He was empirically treated with voriconazole, to which the isolate was susceptible. His consciousness decreased rapidly...
December 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28050341/cutaneous-pythiosis-in-calves-an-epidemiologic-pathologic-serologic-and-molecular-characterization
#20
Guilherme Konradt, Daniele Mariath Bassuino, Matheus Viezzer Bianchi, Lismara Castro, Rafaela Albuquerque Caprioli, Saulo Petinatti Pavarini, Janio M Santurio, Maria Isabel Azevedo, Francielli P Jesus, David Driemeier
This study reports the epidemiological, pathological and mycological findings of cutaneous pythiosis in cattle in southern Brazil. 23 calves, that were kept next to a river with extensive marshy regions, presented ulcerated cutaneous lesions in thoracic and pelvic limbs, sometimes extending to the ventral thoracic region. Histopathological examination revealed multifocal pyogranulomas in the superficial and deep dermis. The Grocott-Methenamine silver, immunohistochemistry anti-Pythium insidiosum, ELISA serology and molecular characterization demonstrated the agent P...
December 2016: Medical Mycology Case Reports
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