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Liver Cancer

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https://www.readbyqxmd.com/read/29234641/albi-score-as-a-novel-tool-in-staging-and-treatment-planning-for-hepatocellular-carcinoma-advantage-of-albi-grade-for-universal-assessment-of-hepatic-function
#1
Atsushi Hiraoka, Kojiro Michitaka, Takashi Kumada, Masashi Kudo
No abstract text is available yet for this article.
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234640/albi-score-as-a-novel-tool-in-staging-and-treatment-planning-for-hepatocellular-carcinoma-is-it-sufficient
#2
Teh-Ia Huo, Po-Hong Liu, Chia-Yang Hsu
No abstract text is available yet for this article.
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234639/hepatocellular-carcinoma-with-macrovascular-invasion-defining-the-optimal-treatment-strategy
#3
REVIEW
Charlotte E Costentin, Cristina R Ferrone, Ronald S Arellano, Suvranu Ganguli, Theodore S Hong, Andrew X Zhu
Background: Tumoral macrovascular invasion (MVI) of hepatic and/or portal vein branches is a common phenomenon in hepatocellular carcinoma (HCC) and is associated with poorer prognosis when compared to HCC without MVI. Summary: Current international guidelines for the management of HCC recommend sorafenib as the only treatment option in case of MVI. Despite guideline recommendations, several alternative options have been tested to manage HCC with MVI: surgery, transarterial chemoembolization, external or internal radiation, hepatic arterial infusion chemotherapy, percutaneous treatment, cryotherapy, or the combination of two or more of these strategies, with or without sorafenib...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234638/prospective-comparison-of-gd-eob-dtpa-enhanced-mri-with-dynamic-ct-for-detecting-recurrence-of-hcc-after-radiofrequency-ablation
#4
Yasuharu Imai, Kazuhiro Katayama, Masatoshi Hori, Takayuki Yakushijin, Kenji Fujimoto, Toshifumi Itoh, Takumi Igura, Mitsuru Sakakibara, Manabu Takamura, Masakatsu Tsurusaki, Hiroto Takahashi, Katsuyuki Nakanishi, Noriaki Usuki, Koh Tsuji, Hiroshi Ohashi, Tonsok Kim, Tetsuo Takehara, Takamichi Murakami
Background: We prospectively compared the efficacy of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) with that of dynamic multidetector computed tomography (MDCT) for detection of recurrent hypervascular hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). Methods: Institutional review board approval and written informed consent were obtained for this multicenter study. Ninety-seven HCC patients treated with curative RFA underwent both Gd-EOB-DTPA-enhanced MRI and dynamic MDCT every 3-4 months...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234637/efficacy-and-safety-of-systemic-therapies-for-advanced-hepatocellular-carcinoma-a-network-meta-analysis-of-phase-iii-trials
#5
Alessandro Cucchetti, Fabio Piscaglia, Antonio Daniele Pinna, Benjamin Djulbegovic, Federico Mazzotti, Luigi Bolondi
Aim/Background: After the introduction of sorafenib in the treatment of advanced hepatocellular carcinoma (HCC), different studies tried to evaluate whether other systemic therapies can improve survival. To provide a comprehensive indirect treatment comparison of efficacy and safety of novel drugs, a network meta-analysis (NMA) of phase III randomized controlled trials was performed. Methods: After pertinent literature search up to November 1, 2016, 6 studies were eligible for the analysis including 4,812 individual patients with advanced HCC: 2,454 received sorafenib, 577 received brivanib, 530 received sunitinib, 514 received linifanib, 358 received sorafenib + erlotinib and 379 received placebo...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234636/validation-and-potential-of-albumin-bilirubin-grade-and-prognostication-in-a-nationwide-survey-of-46-681-hepatocellular-carcinoma-patients-in-japan-the-need-for-a-more-detailed-evaluation-of-hepatic-function
#6
Atsushi Hiraoka, Kojiro Michitaka, Takashi Kumada, Namiki Izumi, Masumi Kadoya, Norihiro Kokudo, Shoji Kubo, Yutaka Matsuyama, Osamu Nakashima, Michiie Sakamoto, Tadatoshi Takayama, Takashi Kokudo, Kosuke Kashiwabara, Masatoshi Kudo
Background/Aim: Recently, albumin-bilirubin (ALBI) scoring/grading, consisting of only albumin and total bilirubin, has been proposed. We examined the efficacy of this grading system for determining hepatic function in patients with hepatocellular carcinoma (HCC). Methods/Materials: The prognoses of 46,681 HCC patients based on results obtained from a nationwide survey conducted in Japan from 2001 to 2007 were evaluated using (1) Japan Integrated Staging (JIS), consisting of Child-Pugh classification and TNM staging (TNM), (2) modified JIS (m-JIS), consisting of liver damage grading and TNM, and (3) ALBI-TNM (ALBI-T), consisting of ALBI grading and TNM, and the results were compared...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234635/treatment-stage-migration-maximizes-survival-outcomes-in-patients-with-hepatocellular-carcinoma-treated-with-sorafenib-an-observational-study
#7
Clarence Yen, Rohini Sharma, Lorenza Rimassa, Tadaaki Arizumi, Dominik Bettinger, Huay Yee Choo, Tiziana Pressiani, Michela E Burlone, Mario Pirisi, Laura Giordano, Anisa Abdulrahman, Masatoshi Kudo, Robert Thimme, Joong Won Park, David James Pinato
Background: Level I evidence supports the use of sorafenib in patients with Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma, where heterogeneity in efficacy exists due to varying clinicopathologic features of the disease. Aim: We evaluated whether prior treatment with curative or locoregional therapies influences sorafenib-specific survival. Methods: From a prospective data set of 785 consecutive patients from international specialist centres, 264 patients (34%) were treatment naïve (TN) and 521 (66%) were pre-treated (PT), most frequently with transarterial chemoembolization (n = 413; 79%)...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234634/association-of-serum-ferritin-with-diabetes-and-alcohol-in-patients-with-non-viral-liver-disease-related-hepatocellular-carcinoma
#8
Rohan C Siriwardana, Madunil A Niriella, Anuradha Dassanayake, Dileepa Ediriweera, Bhagya Gunetilleke, Thenuka Sivasundaram, Janaka de Silva
INTRODUCTION: Non-alcoholic fatty liver disease is a leading cause for hepatocellular carcinoma (HCC) in Sri Lanka. Diabetes mellitus, alcohol abuse, and liver inflammation are known to increase the risk of HCC. The present study evaluates serum ferritin levels in a cohort of patients with non-viral HCC (nvHCC). METHODOLOGY: Consecutive patients with nvHCC presenting to the Colombo North Liver transplant Service, Ragama, from January 2012 to July 2013 were investigated...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234633/clinical-factors-predicting-better-survival-outcome-for-pulmonary-metastasectomy-of-hepatocellular-carcinoma
#9
Tse-Ming Kuo, Kai-Ming Chang, Tsun-I Cheng, Kuo-Jang Kao
Background: In patients with lung metastasis of hepatocellular carcinoma (HCC), it remains uncertain how a better survival outcome can be predicted after metastasectomy. This study aims to identify clinical factors that may be used to guide patient selection for such a therapeutic modality. A total of 28 patients who received pulmonary metastasectomy for HCC between 1993 and 2012 were identified. All relevant clinical factors were extracted from medical records up to September 2015. Patients were classified into high- and low-risk groups according to survival outcome after metastasectomy...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234632/an-ecological-study-of-the-association-between-air-pollution-and-hepatocellular-carcinoma-incidence-in-texas
#10
Luca Cicalese, Loren Raun, Ali Shirafkan, Laura Campos, Daria Zorzi, Mauro Montalbano, Colin Rhoads, Valia Gazis, Katherine Ensor, Cristiana Rastellini
Introduction: Primary liver cancer is a significant cause of cancer-related death in both the United States and the world at large. Hepatocellular carcinoma comprises 90% of these primary liver cancers and has numerous known etiologies. Evaluation of these identified etiologies and other traditional risk factors cannot explain the high incidence rates of hepatocellular carcinoma in Texas. Texas is home to the second largest petrochemical industry and agricultural industry in the nation; industrial activity and exposure to pathogenic chemicals have never been assessed as potential links to the state's increased incidence rate of hepatocellular carcinoma...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234631/sorafenib-versus-hepatic-arterial-infusion-chemotherapy-as-initial-treatment-for-hepatocellular-carcinoma-with-advanced-portal-vein-tumor-thrombosis
#11
Michihisa Moriguchi, Takeshi Aramaki, Hideyuki Nishiofuku, Rui Sato, Koiku Asakura, Kanji Yamaguchi, Toshihiro Tanaka, Masahiro Endo, Yoshito Itoh
Objective: To investigate the validity of hepatic arterial infusion chemotherapy with low-dose 5-fluorouracil and cisplatin (LFP) versus sorafenib as first-line treatment for hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (Vp3, Vp4). Patients and Methods: We retrospectively reviewed the cases of Child-Pugh A advanced HCC with Vp3 or Vp4 treated with LFP or sorafenib between October 2002 and December 2013. Results: There were 32 patients in the LFP group and 14 patients in the sorafenib group...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234630/consensus-on-stereotactic-body-radiation-therapy-for-small-sized-hepatocellular-carcinoma-at-the-7th-asia-pacific-primary-liver-cancer-expert-meeting
#12
Zhao-Chong Zeng, Jinsil Seong, Sang Min Yoon, Jason Chia-Hsien Cheng, Ka-On Lam, Ann-Shing Lee, Ada Law, Jian-Ying Zhang, Yong Hu
Background: Stereotactic body radiation therapy (SBRT) is an advanced technique of external beam radiation therapy that delivers large ablative doses of radiation. In the past decade, many cancer centers have adopted SBRT as one mode of radically treating small-sized hepatocellular carcinoma (HCC), based on encouraging clinical outcomes. SBRT thus seems reasonable as first-line treatment of inoperable HCC confined to the liver. However, most of the clinical studies to date have been retrospective in nature, with key issues still under investigation...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234629/lenvatinib-in-advanced-hepatocellular-carcinoma
#13
EDITORIAL
Masatoshi Kudo
No abstract text is available yet for this article.
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234628/adoption-of-sorafenib-for-the-treatment-of-advanced-stage-hepatocellular-carcinoma-in-oncology-practices-in-the-united-states
#14
Helen M Parsons, Quyen Chu, Jordan J Karlitz, Jennifer L Stevens, Linda C Harlan
Background: The adoption of sorafenib into oncology practice as a first-line systemic treatment for advanced hepatocellular carcinoma (HCC) is not well understood. We examined sorafenib use since Food and Drug Administration (FDA) approval in 2007 and associated survival for individuals diagnosed with advanced HCC, conducting a population-based evaluation of treatment patterns and outcomes for this newly approved drug in the US over time. Methods: We identified individuals diagnosed with Barcelona Clinic Liver Cancer Stage C from the 2007 and 2012 National Cancer Institute Patterns of Care study...
June 2017: Liver Cancer
https://www.readbyqxmd.com/read/28626734/beneficial-effect-of-maintaining-hepatic-reserve-during-chemotherapy-on-the-outcomes-of-patients-with-hepatocellular-carcinoma
#15
Takeshi Terashima, Tatsuya Yamashita, Kuniaki Arai, Kazunori Kawaguchi, Kazuya Kitamura, Taro Yamashita, Yoshio Sakai, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
Hepatocellular carcinoma (HCC) usually develops in chronically damaged liver. We investigated hepatic reserves during chemotherapy of patients with advanced HCC and compensated liver function to evaluate the effect on patients' outcomes of maintaining hepatic reserve after chemotherapy. We retrospectively reviewed the medical records of 190 patients with Child-Pugh A with advanced HCC who were treated with sorafenib or hepatic arterial infusion chemotherapy (HAIC). We investigated the Child-Pugh score and albumin-bilirubin grade for hepatic reserve, and evaluated the effect of the change in Child-Pugh scores on patients' outcomes...
June 2017: Liver Cancer
https://www.readbyqxmd.com/read/28626733/the-overall-survival-of-patients-with-hepatocellular-carcinoma-correlates-with-the-newly-defined-time-to-progression-after-transarterial-chemoembolization
#16
Tadaaki Arizumi, Kazuomi Ueshima, Mina Iwanishi, Tomohiro Minami, Hirokazu Chishina, Masashi Kono, Masahiro Takita, Norihisa Yada, Satoru Hagiwara, Yasunori Minami, Hiroshi Ida, Yoriaki Komeda, Mamoru Takenaka, Toshiharu Sakurai, Tomohiro Watanabe, Naoshi Nishida, Masatoshi Kudo
AIM/BACKGROUND: The ultimate aim of any treatment for hepatocellular carcinoma (HCC) is to improve overall survival (OS); however, the clinical significance of time to progression (TTP) after transarterial chemoembolization (TACE) is unclear. This retrospective study examined the association between OS and the newly defined time to TACE progression (TTTP) to assess whether TTTP can be an alternative to OS in HCC patients with Barcelona Clinic Liver Cancer (BCLC) stage B. METHODS: Between January 2006 and December 2013, 592 patients with HCC (BCLC B1, n = 118; BCLC B2, n = 170) underwent TACE...
June 2017: Liver Cancer
https://www.readbyqxmd.com/read/28626732/albumin-bilirubin-albi-grade-as-part-of-the-evidence-based-clinical-practice-guideline-for-hcc-of-the-japan-society-of-hepatology-a-comparison-with-the-liver-damage-and-child-pugh-classifications
#17
Atsushi Hiraoka, Takashi Kumada, Masatoshi Kudo, Masashi Hirooka, Kunihiko Tsuji, Ei Itobayashi, Kazuya Kariyama, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Toshifumi Tada, Hidenori Toyoda, Kazuhiro Nouso, Kouji Joko, Hideki Kawasaki, Yoichi Hiasa, Kojiro Michitaka
AIM/BACKGROUND: The purpose of this study was to evaluate the validity of 3 classifications for assessing liver function, the liver damage and Child-Pugh classifications and the newly proposed albumin-bilirubin (ALBI) grade, in order to examine the feasibility of evaluating hepatic function using ALBI grade with the hepatocellular carcinoma (HCC) treatment algorithm used in Japan. METHODS: We analyzed the medical records of 3,495 Japanese HCC patients admitted from 2000 to 2015, which were comprised of 1,580 patients hospitalized in the Ehime Prefecture area and used as a training cohort (Ehime group), and 1,915 others who were used for validation (validation group)...
June 2017: Liver Cancer
https://www.readbyqxmd.com/read/28626731/how-to-differentiate-borderline-hepatic-nodules-in-hepatocarcinogenesis-emphasis-on-imaging-diagnosis
#18
REVIEW
Hyun Jeong Park, Byung Ihn Choi, Eun Sun Lee, Sung Bin Park, Jong Beum Lee
BACKGROUND: Rapid advances in liver imaging have improved the evaluation of hepatocarcinogenesis and early diagnosis and treatment of hepatocellular carcinoma (HCC). In this situation, detection of early-stage HCC in its development is important for the improvement of patient survival and optimal treatment strategies. Because early HCCs are considered precursors of progressed HCC, precise differentiation between a dysplastic nodule (DN), especially a high-grade DN, and early HCC is important...
June 2017: Liver Cancer
https://www.readbyqxmd.com/read/28626730/albumin-bilirubin-grade-and-hepatocellular-carcinoma-treatment-algorithm
#19
EDITORIAL
Masatoshi Kudo
No abstract text is available yet for this article.
June 2017: Liver Cancer
https://www.readbyqxmd.com/read/28626729/a-new-era-of-systemic-therapy-for-hepatocellular-carcinoma-with-regorafenib-and-lenvatinib
#20
EDITORIAL
Masatoshi Kudo
No abstract text is available yet for this article.
June 2017: Liver Cancer
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