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Liver Cancer

journal
https://www.readbyqxmd.com/read/27995093/new-perspectives-in-the-treatment-of-colorectal-metastases
#1
REVIEW
Dominique Elias, Luca Viganò, Franco Orsi, Marta Scorsetti, Tiziana Comito, Jan Lerut, Davide Cosola, Guido Torzilli
BACKGROUND: In recent years, the management of metastatic colorectal cancer has become more aggressive and more multidisciplinary. New treatment options have been proposed in addition to the standard approach of resection of liver metastases and chemotherapy. SUMMARY: Selected patients with synchronous limited peritoneal and liver disease (peritoneal cancer index <12 and <3 liver metastases) can be scheduled for aggressive treatment, including cytoreductive surgery, hyperthermic intraperitoneal chemotherapy, and liver resection...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27995092/surgery-of-colorectal-liver-metastases-pushing-the-limits
#2
REVIEW
Guido Torzilli, René Adam, Luca Viganò, Katsunori Imai, Jeremias Goransky, Andrea Fontana, Christian Toso, Pietro Majno, Eduardo de Santibañes
BACKGROUND: The recent advent of more effective chemotherapy and the development of surgical procedures have expanded the pool of resectable patients with colorectal liver metastases (CLM). Two-stage hepatectomy (TSH), associated liver partition and portal vein ligation for staged hepatectomy (ALPPS), and ultrasound-guided enhanced one-stage hepatectomy (e-OSH) are the surgical solutions proposed for these patients, but the range of indications for these procedures vary from institution to institution...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27995091/recent-advances-in-chemotherapy-and-surgery-for-colorectal-liver-metastases
#3
REVIEW
Guillaume Passot, Olivier Soubrane, Felice Giuliante, Giuseppe Zimmitti, Diane Goéré, Suguru Yamashita, Jean-Nicolas Vauthey
BACKGROUND: The liver is the most common site of metastases for colorectal cancer, and combined resection with systemic chemotherapy is the most effective strategy for survival. The aim of this article is to provide a comprehensive summary on four hot topics related to chemotherapy and surgery for colorectal liver metastases (CLM), namely: (1) chemotherapy-related liver injuries: prediction and impact, (2) surgery for initially unresectable CLM, (3) the emerging role of RAS mutations, and (4) the role of hepatic arterial infusion of chemotherapy (HAIC)...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27995090/colorectal-liver-metastases-a-critical-review-of-state-of-the-art
#4
REVIEW
Robert P Jones, Norihiro Kokudo, Gunnar Folprecht, Yoshihiro Mise, Michiaki Unno, Hassan Z Malik, Stephen W Fenwick, Graeme J Poston
BACKGROUND: Over 50% of patients with colorectal cancer will develop liver metastases. Only a minority of patients present with technically resectable disease. Around 40% of those undergoing surgical resection are alive five years after their diagnosis compared with less than 1% for those with disseminated disease treated with systemic chemotherapy. Surgical resection remains the only possibility for long-term survival for these patients and great efforts have been made to increase the rates of resection whilst improving long-term outcomes...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27995089/current-status-on-cholangiocarcinoma-and-gallbladder-cancer
#5
REVIEW
Tomoki Ebata, Giorgio Ercolani, Domenico Alvaro, Dario Ribero, Luca Di Tommaso, Juan W Valle
BACKGROUND: Cholangiocarcinomas (CC) as well as gallbladder cancers are relatively rare and intractable diseases. Clinical, pathological, and epidemiological studies on these tumors have been under investigation. The current status and/or topics on biliary tract cancers have been reported in the East West Association of Liver Tumor (EWALT), held in Milano, Italy in 2015. SUMMARY: All the authors, herein, specifcally reported the current status and leading-edge findings on biliary tract cancers as the following sequence: epidemiology of CC, surgical therapy for intrahepatic CC, surgical therapy for perihilar CC, surgical therapy for gallblad der cancer, chemotherapy for biliary tract cancers, and new histological features in CC...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27995088/current-technical-issues-for-surgery-of-primary-liver-cancer
#6
REVIEW
Yoshikuni Kawaguchi, Goro Honda, Itaru Endo, Daniel Cherqui, Norihiro Kokudo
Primary liver cancer is the fifth most common cancer worldwide. Apart from liver transplantation, surgical resection has been accepted as the effective local treatment for hepatocellular carcinoma (HCC), one of the most common primary liver cancers. Recent technological innovations including navigation technology and intraoperative real-time fluorescence guidance have been utilized for liver resections in clinical practice. With respect to liver resection techniques, the laparoscopic approach has been increasingly gaining popularity as one of the minimally-invasive treatments of HCC...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27995087/surgery-and-hepatocellular-carcinoma
#7
REVIEW
Nobuhisa Akamatsu, Umberto Cillo, Alessandro Cucchetti, Matteo Donadon, Antonio Daniele Pinna, Guido Torzilli, Norihiro Kokudo
The optimal surgical strategy for hepatocellular carcinoma (HCC) is under active debate. Bio-markers of the liver functional reserve as well as volumetric analysis of the future liver remnant are essential for safe liver resection of HCC. The present algorithms applied to surgical strategies for HCC are not ideal because many patients who could potentially undergo safe resection are deemed liver transplant candidates in Western countries, whereas the opposite is the case in Eastern countries. In addition, there is too much focus on expanded criteria for patients with HCC to undergo liver transplantation...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27995086/hepatocellular-carcinoma-the-role-of-interventional-oncology
#8
REVIEW
Matteo Donadon, Luigi Solbiati, Laura Dawson, Aisling Barry, Gonzalo Sapisochin, Paul D Greig, Shuichiro Shiina, Andrea Fontana, Guido Torzilli
BACKGROUND: Hepatocellular carcinoma (HCC) remains a major health issue because of its increasing incidence and because of the complexity of its management. In addition to the traditional potentially curative treatments, i.e., liver transplantation and surgical resection, other new and emerging local therapies have been applied with promising results. SUMMARY: Radiotherapy (RT) and interstitial treatments, such as radiofrequency ablation (RFA), microwave ablation (MWA), and irreversible electroporation (IRE), have recently opened new and interesting treatment scenarios for HCC and are associated with promising results in selected patients...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27995085/transarterial-therapies-for-hepatocellular-carcinoma
#9
REVIEW
Ezio Lanza, Matteo Donadon, Dario Poretti, Vittorio Pedicini, Marco Tramarin, Massimo Roncalli, Hyungjin Rhee, Young Nyun Park, Guido Torzilli
BACKGROUND: The treatment of hepatocellular carcinoma (HCC) is still a major health issue because of its increasing incidence and because of the complexity of its management. Transarterial embolization (TAE) and transarterial chemoembolization (TACE) are two widely used locoregional therapies in the treatment of HCC, especially for unresectable intermediate and advanced HCCs. SUMMARY: The modern use of TAE and TACE opens new scenarios for the treatment of unresectable HCC and has yielded interesting results...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27995084/hepatocellular-carcinoma-therapeutic-guidelines-and-medical-treatment
#10
REVIEW
Masatoshi Kudo, Franco Trevisani, Ghassan K Abou-Alfa, Lorenza Rimassa
Western and Eastern perspectives on therapeutic guidelines for hepatocellular carcinoma (HCC) have many commonalities but may also differ in certain aspects, as described in this article. In view of the limited therapeutic options for advanced HCC, evidence-based therapies are few, and thus there is a dependence on consensus-based guidelines. This article focuses on the Italian Association for the Study of the Liver guidelines and the Japanese approaches to therapy, while drawing attention to certain controversies from other academic bodies where applicable and appropriate...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27995083/ewalt-east-meets-west-in-a-multidisciplinary-setting-to-improve-the-management-of-liver-tumors
#11
EDITORIAL
Guido Torzilli, Jean-Nicolas Vauthey, Jacques Belghiti, Masatoshi Makuuchi, Matteo Donadon, Luca Viganò, Norihiro Kokudo
No abstract text is available yet for this article.
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27995082/immune-checkpoint-blockade-in-hepatocellular-carcinoma-2017-update
#12
EDITORIAL
M Kudo
No abstract text is available yet for this article.
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27781202/selective-internal-radiation-therapy-sirt-as-conversion-therapy-for-unresectable-primary-liver-malignancies
#13
REVIEW
Alessandro Cucchetti, Alberta Cappelli, Giorgio Ercolani, Cristina Mosconi, Matteo Cescon, Rita Golfieri, Antonio Daniele Pinna
BACKGROUND: Many patients with primary liver cancers are not candidates for surgery, and systemic therapies are seldom effective. Selective internal radiation therapy (SIRT) has been shown to obtain partial and even complete response in unresectable primary tumors. As a "side effect", SIRT can induce contra-lateral liver hypertrophy. Tumor response to SIRT can be sufficient to allow disengagement from normal vital structures whose involvement is the cause of the initial unresectability...
October 2016: Liver Cancer
https://www.readbyqxmd.com/read/27781201/molecular-pathogenesis-of-hepatocellular-carcinoma
#14
Daniel Wai-Hung Ho, Regina Cheuk-Lam Lo, Lo-Kong Chan, Irene Oi-Lin Ng
The pathogenesis of hepatocellular carcinoma (HCC) is a multistep process involving the progressive accumulation of molecular alterations pinpointing different molecular and cellular events. The next-generation sequencing technology is facilitating the global and systematic evaluation of molecular landscapes in HCC. There is emerging evidence supporting the importance of cancer metabolism and tumor microenvironment in providing a favorable and supportive niche to expedite HCC development. Moreover, recent studies have identified distinct surface markers of cancer stem cell (CSC) in HCC, and they also put forward the profound involvement of altered signaling pathways and epigenetic modifications in CSCs, in addition to the concomitant drug resistance and metastasis...
October 2016: Liver Cancer
https://www.readbyqxmd.com/read/27781200/is-surgical-resection-justified-for-advanced-intrahepatic-cholangiocarcinoma
#15
Tomoaki Yoh, Etsuro Hatano, Kenya Yamanaka, Takahiro Nishio, Satoru Seo, Kojiro Taura, Kentaro Yasuchika, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto
BACKGROUNDS: Prognosis for patients with advanced intrahepatic cholangiocarcinoma (ICC) with intrahepatic metastasis (IM), vascular invasion (VI), or regional lymph node metastasis (LM) remains poor. The aim of this study was to clarify the indications for surgical resection for advanced ICC. METHODS: We retrospectively divided 213 ICC patients treated at Kyoto University Hospital between 1993 and 2013 into a resection (n=164) group and a non-resection (n=49) group...
October 2016: Liver Cancer
https://www.readbyqxmd.com/read/27781199/feasibility-of-extracted-overlay-fusion-imaging-for-intraoperative-treatment-evaluation-of-radiofrequency-ablation-for-hepatocellular-carcinoma
#16
Yuki Makino, Yasuharu Imai, Takumi Igura, Sachiyo Kogita, Yoshiyuki Sawai, Kazuto Fukuda, Takayuki Iwamoto, Junya Okabe, Manabu Takamura, Norihiko Fujita, Masatoshi Hori, Tetsuo Takehara, Masatoshi Kudo, Takamichi Murakami
BACKGROUND AND AIMS: Extracted-overlay fusion imaging is a novel computed tomography/magnetic resonance-ultrasonography (CT/MR-US) imaging technique in which a target tumor with a virtual ablative margin is extracted from CT/MR volume data and synchronously overlaid on US images. We investigated the applicability of the technique to intraoperative evaluation of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). METHODS: This retrospective study analyzed 85 HCCs treated with RFA using extracted-overlay fusion imaging for guidance and evaluation...
October 2016: Liver Cancer
https://www.readbyqxmd.com/read/27781198/novel-pretreatment-scoring-incorporating-c-reactive-protein-to-predict-overall-survival-in-advanced-hepatocellular-carcinoma-with-sorafenib-treatment
#17
Hiroyuki Nakanishi, Masayuki Kurosaki, Kaoru Tsuchiya, Yutaka Yasui, Mayu Higuchi, Tsubasa Yoshida, Yasuyuki Komiyama, Kenta Takaura, Tsuguru Hayashi, Konomi Kuwabara, Natsuko Nakakuki, Hitomi Takada, Masako Ueda, Nobuharu Tamaki, Shoko Suzuki, Jun Itakura, Yuka Takahashi, Namiki Izumi
OBJECTIVES: This study aimed to build a prediction score of prognosis for patients with advanced hepatocellular carcinoma (HCC) after sorafenib treatment. METHODS: A total of 165 patients with advanced HCC who were treated with sorafenib were analyzed. Readily available baseline factors were used to establish a scoring system for the prediction of survival. RESULTS: The median survival time (MST) was 14.2 months. The independent prognostic factors were C-reactive protein (CRP) <1...
October 2016: Liver Cancer
https://www.readbyqxmd.com/read/27781197/surgery-for-intermediate-and-advanced-hepatocellular-carcinoma-a-consensus-report-from-the-5th-asia-pacific-primary-liver-cancer-expert-meeting-apple-2014
#18
Ming-Chih Ho, Kiyoshi Hasegawa, Xiao-Ping Chen, Hiroaki Nagano, Young-Joo Lee, Gar-Yang Chau, Jian Zhou, Chih-Chi Wang, Young Rok Choi, Ronnie Tung-Ping Poon, Norihiro Kokudo
BACKGROUND: The Barcelona Clinic Liver Cancer (BCLC) staging and treatment strategy does not recommended surgery for treating BCLC stage B and C hepatocellular carcinoma (HCC). However, numerous Asia-Pacific institutes still perform surgery for this patient group. This consensus report from the 5th Asia-Pacific Primary Liver Cancer Expert Meeting aimed to share opinions and experiences pertaining to liver resection for intermediate and advanced HCCs and to provide evidence to issue recommendations for surgery in this patient group...
October 2016: Liver Cancer
https://www.readbyqxmd.com/read/27781196/regorafenib-as-second-line-systemic-therapy-may-change-the-treatment-strategy-and-management-paradigm-for-hepatocellular-carcinoma
#19
EDITORIAL
https://www.readbyqxmd.com/read/27493897/personalized-clinical-trials-in-hepatocellular-carcinoma-based-on-biomarker-selection
#20
REVIEW
Bingnan Zhang, Richard S Finn
BACKGROUND: Since the approval of sorafenib there have been numerous failures of new agents in Phase III studies for treatment of advanced hepatocellular carcinoma (HCC). These studies have generally ignored the molecular heterogeneity of HCC and they have not enrolled patients based on predictive markers of response. The development of molecular targeted therapeutics in HCC needs to model the approach that has been taken with great success in other solid tumors, to decrease the likelihood of failure in future studies...
July 2016: Liver Cancer
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