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Sanne M T Raes, Ludovic Jourdin, Livio Carlucci, Adriaan van den Bruinhorst, David P B T B Strik, Cees J N Buisman
The conversion of organic waste streams into carboxylic acids as renewable feedstocks results in relatively dilute aqueous streams. Carboxylic acids can be recovered from such streams by using liquid-liquid extraction. Hydrophobic ionic liquids (ILs) are novel extractants that can be used for carboxylic acid recovery. To integrate these ILs as in situ extractants in several biotechnological applications, the IL must be compatible with the bioprocesses. Herein the ILs [P666,14 ][oleate] and [N8888 ][oleate] were synthesized in water and their bioprocess compatibility was assessed by temporary exposure to an aqueous phase that contained methanogenic granular sludge...
November 2018: ChemistryOpen
Anirban Karmakar, Guilherme M D M Rúbio, M Fátima C Guedes da Silva, Armando J L Pombeiro
The reactions of 3,3'-{(pyridine-2,6-dicarbonyl)bis(azanediyl)}dibenzoic acid (H2 L) with zinc(II), cadmium(II), and samarium(III) nitrates were studied, and the obtained compounds, [Zn(1κ O :2κ O' -L)(H2 O)2 ] n ( 1 ), [Cd(1κ O 2 :2κ O 2 -L)(H2 O)2 ]2 ⋅ 6 n  H2 O ⋅ n  C4 H8 O2 ⋅ 1.5 n  DMF ( 2 ), and [Sm(1κ O :2κO ' O '' :3κ O''' -L)(NO3 )(H2 O)(dmf)] n ⋅ n  DMF ( 3 ), were characterized by elemental analysis, FTIR spectroscopy, thermogravimetric analysis, and X-ray single-crystal diffraction...
November 2018: ChemistryOpen
Caroline E Knapp, Elizabeth A Metcalf, Shreya Mrig, Clara Sanchez-Perez, Samuel P Douglas, Patrick Choquet, Nicolas D Boscher
Bidentate diamine and amino-alcohol ligands have been used to form solid, water-soluble, and air-stable monomeric copper complexes of the type [Cu(NH2 CH2 CH(R)Y)2 (NO3 )2 ] ( 1 , R=H, Y=NH2 ; 2 , R=H, Y=OH; 3 , R=Me, Y=OH). The complexes were characterized by elemental analysis, mass spectrometry, infrared spectroscopy, thermal gravimetric analysis, and single-crystal X-ray diffraction. Irrespective of their decomposition temperature, precursors 1 - 3 yield highly conductive copper features [1.5×10-6  Ω m (±5×10-7  Ω m)] upon atmospheric-pressure plasma-enhanced sintering...
November 2018: ChemistryOpen
Masamune Morita, Kaoru Katoh, Naohiro Noda
Bacterial cultivation techniques are classic, basic, and common processes used to characterize the physiological activity of bacteria in their environment. Owing to recent advances in bacterial cultivation techniques, the physiological activity of bacteria can be elucidated at the single-cell culture level. Here, we report a novel method to monitor the real-time activity of bacterial growth at the single-cell level inside giant unilamellar vesicles (GUVs). This method consists of two steps: 1) encapsulation of single bacteria in 1-33 pL scale GUVs and 2) immobilization of the GUVs on a planar lipid bilayer membrane on a glass surface...
November 2018: ChemistryOpen
Masamune Morita, Kaoru Katoh, Naohiro Noda
Invited for this month's cover picture are Dr. Masamune Morita, Dr. Kaoru Katoh and Dr. Naohiro Noda from the Biomedical Research Institute at the National Institute of Advanced Industrial Science and Technology (AIST, Japan). The cover picture shows direct monitoring of real-time activity of bacterial growth at the single-cell level inside giant unilamellar vesicles (GUVs); entrapped single bacterial cells are actively increasing to a great number of cells inside GUVs. This study shows new applications for GUVs, and can offer a novel tool for culturing bacteria in bacterial studies...
November 2018: ChemistryOpen
Andrea Pinto, Zeina El Ali, Sébastien Moniot, Lucia Tamborini, Clemens Steegborn, Roberta Foresti, Carlo De Micheli
Natural and synthetic electrophilic compounds have been shown to activate the antioxidant protective Nrf2 (nuclear factor erythroid 2-related factor 2)/heme oxygenase-1 (HO-1) axis in cells and tissues. Here, we tested the ability of different isoxazoline-based electrophiles to up-regulate Nrf2/HO-1. The potency of activation is dependent on the leaving group at the 3-position of the isoxazoline nucleus, and an additional ring on the molecule limits the Nrf2/HO-1 activating properties. Among the synthetized compounds, we identified 3-bromo-5-phenyl-4,5-dihydroisoxazole 1 as the derivative with best activating properties in THP-1 human monocytic cells...
November 2018: ChemistryOpen
Osama Saber, Abdullah Aljaafari, Mostafa Osama, Hasan Alabdulgader
The present study has two aims, first to accelerate the degradation of pollutants by coating carbon nanotubes (CNTs) with nanoplatelets or nanocomposites of aluminum zinc oxides and second to fabricate an advanced photocatalyst. Accordingly, Zn-Al layered double hydroxides (LDHs) were grown in the presence of functionalized CNTs during urea hydrolysis. The presence of CNTs led to the formation of LDH nanoplatelets, and TEM images showed that the CNTs were coated with nanoplatelets. The nanoplatelets were thermally treated to form nanocomposite-coated CNTs...
October 2018: ChemistryOpen
Pingping Zhao, Hongyou Cui, Yunyun Zhang, Yuan Zhang, Yong Wang, Yali Zhang, Yujiao Xie, Weiming Yi
The effective dehydration of glucose to 5-hydroxymethylfurfural (HMF) has attracted increasing attention. Herein, a series of sulfonic-acid-functionalized ionic liquid (IL)-heteropolyacid (HPA) hybrid catalysts are proposed for the conversion of glucose to HMF. A maximum total yield of HMF and levoglucosan (LGA; ≈71 %) was achieved in the presence of pyrazine IL-HPA hybrid catalyst [PzS]H2 PW in THF/H2 O-NaCl (v/v 5:1). The mechanism of glucose dehydration was studied by tailoring the Brønsted/Lewis acid sites of the hybrid catalysts and altering the solvent composition...
October 2018: ChemistryOpen
Nagwa M M Hamada
In this study, 2-mercapto-3-phenyl-2,3-dihydro-1 H -quinazolin-4-one ( 1 ), which exists as a thiol and thione tautomer, was treated with acetylacetone to give the target compound, namely, 1-methyl-5-phenyl-5 H -pyrido[1,2- a ]quinazoline-3,6-dione ( 2 ). The spectroscopic data, including UV/Vis, IR, 1 H NMR, 13 C NMR, and mass data, of this compound were recorded. The molecular structures of the starting material ( 1 ) and the product ( 2 ) were optimized by using density functional theory (DFT) by employing the B3LYP exchange correlation with the 6-311G (d, p) and 6-31G++ (d, p) basis sets...
October 2018: ChemistryOpen
Sheng-Yan Zhang, Kai Yu, Yu-Shuang Guo, Rui-Qi Mou, Xiao-Fan Lu, Dian-Shun Guo
A new type of heterogeneous palladium catalyst, PdMgAl-LDH, was facilely prepared by the immobilization of Pd2+ species in the layers of a Mg-Al layered double hydroxide (LDH) with co-precipitation, and then fully characterized by using powder XRD, thermogravimetric differential thermal analysis, TEM, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy techniques. These catalysts can efficiently catalyze copper-free Sonogashira, Suzuki and Heck coupling reactions of various aryl iodides, bromides, and chlorides in aqueous media under phosphine-ligand- and organic-base-free conditions...
October 2018: ChemistryOpen
Xinghui Jin, Jianhua Zhou, Bingcheng Hu
Density functional theory was employed to investigate ten 1,2,4,5-tetrahydro-1,2,4,5-tetrazine-based energetic materials. The heats of formation and detonation properties were calculated by isodesmic reactions and Kamlet-Jacobs equations. The thermal stabilities and impact sensitivities were also estimated to give a better understanding of their decomposition mechanism. The results indicate that all of the designed compounds have high positive heats of formation ranging from 525.1 to 1639.1 kJ mol-1 , moderate detonation properties (heats of detonation of 536...
October 2018: ChemistryOpen
Rita B Restani, Rita F Pires, Anna Tolmatcheva, Rita Cabral, Pedro V Baptista, Alexandra R Fernandes, Teresa Casimiro, Vasco D B Bonifácio, Ana Aguiar-Ricardo
POxylated polyurea dendrimer (PUREG4 OOx48 )-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2 -assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4 OOx48 nanoparticles were much more cytotoxic than the free drug...
October 2018: ChemistryOpen
Shinya Kimura, Naoki Saito
A formal total synthesis of the antitumor marine natural product ( rac )-renieramycin T, which possesses a characteristic ecteinascidin-type A ring in the renieramycin-saframycin core skeleton, was elaborated. The key steps in the synthesis of ( rac )-renieramycin T are a modified Pictet-Spengler cyclization of dialkylated oxomalonate derivatives and decarboxylation via a monocarboxylic acid derivative followed by stereocontrolled protonation of the enol intermediate. A key intermediate in our previous synthesis of renieramycin T was used, and the formal synthesis was accomplished in 21 steps from a known piperazine-2,5-dione derivative...
October 2018: ChemistryOpen
Adolfo Fernández-Figueiras, Fátima Lucio-Martínez, Paula Munín-Cruz, Juan M Ortigueira, Paula Polo-Ces, Francisco Reigosa, M Teresa Pereira, José M Vila
In the world of science, in particular the section concerning the field of chemistry, when the results encountered during the experiment do not meet our expectations, our shrewdness may play an important role to open up new unexplored fields that could be much more interesting than what we were seeking. In those cases, our research undergoes an unforeseen shift, delivering novel and challenging results that may altogether alter our point of view and our future work. We have then struck serendipity. Specifically, in our investigation linked to palladacycles we have found that the new trends in their reactivity, as well as in their structure, have been, in many cases, related to this experience, broadening our research scope within this field...
October 2018: ChemistryOpen
Emőke Sikora, Ádám Prekob, Gyula Halasi, László Vanyorek, Péter Pekker, Ferenc Kristály, Tamás Varga, János Kiss, Zoltán Kónya, Béla Viskolcz
Nitrogen-doped, bamboo-like carbon nanotubes (BCNTs) were synthesized from butylamine by catalytic chemical vapor deposition (CCVD method). The nanotubes were oxidized by H2 SO4 /HNO3 treatment and used to prepare calcium alginate gelled BCNT spheres. These beads were first carbonized and then Pd, Rh and Ni nanoparticles were anchored on the surface of the spheres. These systems were then applied as catalysts in CO2 hydrogenation. The BCNT support was examined by Raman spectroscopy, dynamic light scattering (DLS) and X-ray photoelectron spectroscopy (XPS)...
October 2018: ChemistryOpen
Selda Ozkan, JeongEun Yoo, Nhat Truong Nguyen, Shiva Mohajernia, Raul Zazpe, Jan Prikryl, Jan M Macak, Patrik Schmuki
In the present work, we report the use of TiO2 nanotube (NT) layers with a regular intertube spacing that are decorated by Pt nanoparticles through the atomic layer deposition (ALD) of Pt. These Pt-decorated spaced (SP) TiO2 NTs are subsequently explored for photocatalytic H2 evolution and are compared to classical close-packed (CP) TiO2 NTs that are also decorated with various amounts of Pt by using ALD. On both tube types, by varying the number of ALD cycles, Pt nanoparticles of different sizes and areal densities are formed, uniformly decorating the inner and outer walls from tube top to tube bottom...
October 2018: ChemistryOpen
Shinya Kimura, Naoki Saito
Invited for this month's cover picture is the group of Professor Naoki Saito at the Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University (Japan). They achieved the first total synthesis of renieramycin T in 2016, and they have been following an alternative route to supply a large amount of it in order to promote research of the next stage, such as structure-activity relationship studies. This paper reports a formal total synthesis in 21 steps from a known piperazine-2,5-dione derivative...
October 2018: ChemistryOpen
Boulos Zacharie, Shaun D Abbott, Jean-Simon Duceppe, Lyne Gagnon, Brigitte Grouix, Lilianne Geerts, Liette Gervais, François Sarra-Bournet, Valérie Perron, Nicole Wilb, Christopher L Penney, Pierre Laurin
Low-molecular-weight synthetic molecules 1 with the general 2-(fluorophenylamino)-4,6-disubstituted 1,3,5-triazine structure and showing anti-inflammatory and anticancer activities were explored. Structure-activity relationship studies demonstrated the importance of the aminopentyl chain, the 3- or 4-fluorophenylaniline component, and the presence of at least one substituent, such as a tyramine moiety, attached directly to the triazine ring as essential for good activity. These compounds, represented by leads 4-{2-[4-(5-Aminopentylamino)-6-(3-fluorophenylamino)-1,3,5-triazin-2-ylamino]ethyl}phenol ( 6 ) and 4-{2-[4-(5-Aminopentylamino)-6-(4-fluorophenylamino)-1,3,5-triazin-2-ylamino]ethyl}phenol ( 10 ), displayed moderate and significant in vitro and in vivo dual activities, respectively, and address the molecular link between inflammation and cancer...
September 2018: ChemistryOpen
Xican Li, Qian Jiang, Ban Chen, Xiaoling Luo, Dongfeng Chen
The structure-activity relationships of 31 xanthones were analyzed by using the ferric reducing antioxidant power (FRAP) assay to determine their electron-transfer (ET) potential. It was proven that the ET potential of xanthones was dominated by four moieties (i.e. hydroquinone moiety, 5,6-catechol moiety, 6,7-catechol moiety, and 7,8-catechol moiety) and was only slightly affected by other structural features, including a single phenolic OH group, the resorcinol moiety, the transannular dihydroxy moiety, a methoxy group, a sugar residue, an isoprenyl group, a cyclized isoprenyl group, and an isopentanol group...
September 2018: ChemistryOpen
László Szabó, Sari Imanishi, Naohiro Kawashima, Rina Hoshino, Daisuke Hirose, Takayuki Tsukegi, Kazuaki Ninomiya, Kenji Takahashi
Given our possible future dependence on carbon fiber reinforced composites, the introduction of a renewable matrix might be advantageous for the vision of a sustainable world. Cellulose is a superior green candidate and provides exceptional freedom in composite design as the free OH groups can be conveniently functionalized to give tailor-made materials. To obtain a high-performing carbon fiber reinforced cellulose propionate composite, we accurately tailored the interfacial adhesion by invoking click chemistry...
September 2018: ChemistryOpen
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