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https://www.readbyqxmd.com/read/29321951/utility-of-the-phenacyl-protecting-group-in-traceless-protein-semisynthesis-through-ligation-desulfurization-chemistry
#1
Maria Matveenko, Stefanie Hackl, Christian F W Becker
Semisynthesis of proteins via expressed protein ligation is a widely applicable method, even more so because of the possibility of ligation at non-cysteine sites using β-mercapto amino acids that can be converted to the corresponding native amino acids by desulfurization. A drawback of this ligation- desulfurization approach is the removal of any unprotected native cysteine residues within the ligated protein segments. Here, we show that the phenacyl (PAc) moiety can be successfully used to protect cysteines within recombinantly generated protein segments...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29318102/extending-the-scope-of-19f-hyperpolarization-through-signal-amplification-by-reversible-exchange-in-mri-and-nmr-spectroscopy
#2
Alexandra M Olaru, Thomas B R Robertson, Jennifer S Lewis, Alex Antony, Wissam Iali, Ryan E Mewis, Simon B Duckett
Fluorinated ligands have a variety of uses in chemistry and industry, but it is their medical applications as 18F-labelled positron emission tomography (PET) tracers where they are most visible. In this work, we illustrate the potential of using 19F-containing ligands as future magnetic resonance imaging (MRI) contrast agents and as probes in magnetic resonance spectroscopy studies by significantly increasing their magnetic resonance detectability through the signal amplification by reversible exchange (SABRE) hyperpolarization method...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29318101/n-type-doped-silicon-thin-film-on-a-porous-cu-current-collector-as-the-negative-electrode-for-li-ion-batteries
#3
Aliya Mukanova, Arailym Nurpeissova, Sung-Soo Kim, Maksym Myronov, Zhumabay Bakenov
This work reports the preparation of a three-dimensional Si thin film negative electrode employing a porous Cu current collector. A previously reported copper etching procedure was modified to develop the porous structures inside a 9 μm thick copper foil. Magnetron sputtering was used for the deposition of an n-type doped 400 nm thick amorphous Si thin film. Electrochemical cycling of the prepared anode confirmed the effectiveness of utilizing the approach. The designed Si thin film electrode retained a capacity of around 67 μAh cm-2 (1675 mAh g-1) in 100th cycle...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29318100/hydrogenolysis-of-c-o-chemical-bonds-of-broad-scope-mediated-by-a-new-spherical-sol-gel-catalyst
#4
Valerica Pandarus, Rosaria Ciriminna, Geneviève Gingras, François Béland, Mario Pagliaro, Serge Kaliaguine
The new spherical sol-gel hybrid material SiliaCat Pd0 selectively mediates the hydrogenolysis of aromatic alcohols, aldehydes, and ketones by using an ultralow catalytic amount (0.1 mol % Pd) under mild reaction conditions. The broad reaction scope as well as the catalyst's superior activity and pronounced stability open the route to green and convenient reductive deoxygenation processes of primary synthetic relevance in chemical research as well as in the fine chemical and petrochemical industries.
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29318099/a-small-molecule-impedes-insulin-fibrillation-another-new-role-of-phenothiazine-derivatives
#5
Meghomukta Mukherjee, Jagannath Jana, Subhrangsu Chatterjee
Protein misfolding is interrelated to several diseases, including neurodegenerative diseases and type II diabetes. Misfolded/unfolded proteins produce soluble oligomers that accumulate into "amyloid plaques". Inhibition of amyloid-plaque formation by those misfolded/unfolded proteins will lead to the invention of new therapeutic approaches for amyloid-related diseases. Herein, methylene blue (MB), a well-defined drug against multiple diseases and disorders, is used to impede insulin fibrillation. In this study, we perform an array of in vitro experiments to monitor the effects of MB on the fibrillation of bovine insulin...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29318098/synthesis-and-liquid-crystalline-properties-of-unsymmetrically-substituted-naphthalenediimides-with-a-polar-headgroup-effect-of-amide-hydrogen-bonding-and-alkyl-chain-length
#6
Namdev V Ghule, Rajesh S Bhosale, Sidhanath V Bhosale, Turlapati Srikanth, Nandiraju V S Rao, Sheshanath V Bhosale
A series of new unsymmetrically substituted naphthalenediimide (NDI) moieties NDI-1 to NDI-6 were synthesized. The structures of these compounds were confirmed by means of FT-IR, 1H NMR, 13C NMR, ESI-mass and HRMS spectroscopic measurements. UV/Vis and fluorescence spectroscopy were employed to investigate the photophysical properties of the prepared compounds in solution and in the solid state. Using the onset of UV/Vis absorption, the optical band gaps were calculated. Cyclic voltammetry measurements were performed to study the electrochemical behavior and to calculate the LUMO energy levels...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29318097/flavin-based-light-driven-fluorescent-probe-for-the-detection-of-antioxidant-amino-acids
#7
Kyeong-Im Hong, Seong Min Lee, Woo-Dong Jang
We have synthesized a flavin-N(5)-oxide derivative with a p-toluenesulfonyl (Ts-OF) group as a "turn-on" fluorescent probe for the detection of several antioxidant amino acids and biothiols. Oxidized flavin was synthesized by using dithiothreitol as the reducing agent. Ts-OF showed a light-driven fluorescence enhancement in the presence of several amino acids and biothiols such as histidine (His), methionine (Met), cysteine (Cys), glutathione (GSH), and homocysteine (Hcy). The 1H NMR study indicated the reductive elimination of the p-toluenesulfonyl group from Ts-OF in the presence of antioxidants and photo-irradiation...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29318096/a-two-photon-ratiometric-fluorescent-probe-for-imaging-of-hydrogen-peroxide-levels-in-rat-organ-tissues
#8
Chang Su Lim, Myoung Ki Cho, Mi Yeon Park, Hwan Myung Kim
Hydrogen peroxide (H2O2) is important in the regulation of a variety of biological processes and is involved in various diseases. Quantitative measurement of H2O2 levels at the subcellular level is important for understanding its positive and negative effects on biological processes. Herein, a two-photon ratiometric fluorescent probe (SHP-Cyto) with a boronate-based carbamate leaving group as the H2O2 reactive trigger and 6-(benzo[d]thiazol-2'-yl)-2-(N,N-dimethylamino) naphthalene (BTDAN) as the fluorophore was synthesized and examined for its ability to detect cytosolic H2O2 in situ...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29318095/green-and-red-fluorescent-dyes-for-translational-applications-in-imaging-and-sensing-analytes-a-dual-color-flag
#9
REVIEW
Elisabete Oliveira, Emilia Bértolo, Cristina Núñez, Viviane Pilla, Hugo M Santos, Javier Fernández-Lodeiro, Adrian Fernández-Lodeiro, Jamila Djafari, José Luis Capelo, Carlos Lodeiro
Red and green are two of the most-preferred colors from the entire chromatic spectrum, and red and green dyes are widely used in biochemistry, immunohistochemistry, immune-staining, and nanochemistry applications. Selective dyes with green and red excitable chromophores can be used in biological environments, such as tissues and cells, and can be irradiated with visible light without cell damage. This critical review, covering a period of five years, provides an overview of the most-relevant results on the use of red and green fluorescent dyes in the fields of bio-, chemo- and nanoscience...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29318094/translational-chemistry-the-future-in-science
#10
EDITORIAL
Carlos Lodeiro, Jose Luis Capelo
No abstract text is available yet for this article.
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29318093/onwards-and-upwards-for-chemistryopen
#11
EDITORIAL
Kate Lawrence
No abstract text is available yet for this article.
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29318092/green-and-red-fluorescent-dyes-for-translational-applications-in-imaging-and-sensing-analytes-a-dual-color-flag
#12
Elisabete Oliveira, Emilia Bértolo, Cristina Núñez, Viviane Pilla, Hugo M Santos, Javier Fernández-Lodeiro, Adrian Fernández-Lodeiro, Jamila Djafari, José Luis Capelo, Carlos Lodeiro
Invited for this month's cover picture is the BIOSCOPE group of Professors Carlos Lodeiro and José Luis Capelo at the REQUIMTE/UCIBIO-LAQv-FCT University NOVA of Lisbon (Portugal), and their collaborators. The cover picture is devoted to Translational Research, and shows the Portuguese Flag represented by the interaction between cells and Janus gold/silver nanoparticles functionalized with rhodamine (red) and Fluorescein (green) dyes as tools for biomedical translational research. Read the full text of their Review at 10...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29226062/interactions-of-protonated-guanidine-and-guanidine-derivatives-with-multiply-deprotonated-rna-probed-by-electrospray-ionization-and-collisionally-activated-dissociation
#13
Jovana Vušurović, Eva-Maria Schneeberger, Kathrin Breuker
Interactions of ribonucleic acid (RNA) with guanidine and guanidine derivatives are important features in RNA-protein and RNA-drug binding. Here we have investigated noncovalently bound complexes of an 8-nucleotide RNA and six different ligands, all of which have a guanidinium moiety, by using electrospray ionization (ESI) and collisionally activated dissociation (CAD) mass spectrometry (MS). The order of complex stability correlated almost linearly with the number of ligand atoms that can potentially be involved in hydrogen-bond or salt-bridge interactions with the RNA, but not with the proton affinity of the ligands...
December 2017: ChemistryOpen
https://www.readbyqxmd.com/read/29226061/shaping-polyyne-rods-by-using-an-electric-field
#14
Esther Rozental, Eli Altus, Dan Thomas Major, Shmaryahu Hoz
When a homogenous electric field is applied to polyynes (C10 and C20) perpendicular to their long axis, they bend to form an arch. The height of the arch is proportional to the intensity of the electric field. The direction of the bend and its magnitude depend on the electronic nature (donor/acceptor) of the substituents at the termini of the polyyne. The driving force for the formation of the arch is the dipole moment produced in the system parallel to the electric field. This dipole moment stems from the substituents and from additional polarization by the field...
December 2017: ChemistryOpen
https://www.readbyqxmd.com/read/29226060/stable-europium-iii-complexes-with-short-linkers-for-site-specific-labeling-of-biomolecules
#15
Felix Faschinger, Martin Ertl, Mirjam Zimmermann, Andreas Horner, Markus Himmelsbach, Wolfgang Schöfberger, Günther Knör, Hermann J Gruber
In this study, two new terpyridine-based EuIII complexes were synthesized, the structures of which were optimized for luminescence resonance energy-transfer (LRET) experiments. The complexes showed high quantum yields (32 %); a single long lifetime (1.25 ms), which was not influenced by coupling to protein; very high stability in the presence of chelators such as ethylenediamine-N,N,N',N'-tetraacetate and ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid; and no interaction with cofactors such as adenosine triphosphate and guanosine triphosphate...
December 2017: ChemistryOpen
https://www.readbyqxmd.com/read/29226059/reversible-broad-spectrum-control-of-selective-reflections-of-chiral-nematic-phases-by-closed-open-type-axially-chiral-azo-dopants
#16
Hiroya Nishikawa, Daigou Mochizuki, Hiroki Higuchi, Yasushi Okumura, Hirotsugu Kikuchi
We demonstrate reversible RGB-color photocontrol of a chiral nematic liquid crystal (N*LC) by using newly synthesized closed- and open-type chiral dopants. The photoswitching elements in the dopants are azobenzene units on axially chiral binaphthyl cores. Owing to cis-trans photoisomerization of the azobenzene units, both closed- and open-type compounds showed higher solubility, larger helical twisting power (HTP), and larger changes in HTP than conventional chiral dopants in host LCs. Thus, even at very low dopant concentrations, we successfully controlled the chirality of the induced helical structure of the N*LCs...
December 2017: ChemistryOpen
https://www.readbyqxmd.com/read/29226058/towards-fingermark-dating-a-raman-spectroscopy-proof-of-concept-study
#17
Per Ola Andersson, Christian Lejon, Therese Mikaelsson, Lars Landström
Fingermarks have, for a long time, been vital in the forensic community for the identification of individuals, and a possibility to non-destructively date the fingermarks would of course be beneficial. Raman spectroscopy is, herein, evaluated for the purpose of estimating the age of fingermarks deposits. Well-resolved spectra were non-destructively acquired to reveal spectral uniqueness, resembling those of epidermis, and several molecular markers were identified that showed different decay kinetics: carotenoids > squalene > unsaturated fatty acids > proteins...
December 2017: ChemistryOpen
https://www.readbyqxmd.com/read/29226057/photocatalytic-overall-water-splitting-over-mil-125-ti-upon-copi-and-pt-co-catalyst-deposition
#18
Yang An, Benyan Xu, Yuanyuan Liu, Zeyan Wang, Peng Wang, Ying Dai, Xiaoyan Qin, Xiaoyang Zhang, Baibiao Huang
Photocatalytic overall water splitting is realized by taking advantage of the semiconductive and porous properties of MIL-125(Ti). CoPi and Pt are deposited into MIL-125(Ti) in two steps. The co-catalysts CoPi and Pt not only act as reactive sites for oxygen and hydrogen evolution, respectively, but also improve the photogenerated charge separation efficiency. The above conclusions are supported by the photoelectrical and photophysical results.
December 2017: ChemistryOpen
https://www.readbyqxmd.com/read/29226056/%C3%AE-deuterium-isotope-effects-on-firefly-luciferase-bioluminescence
#19
Michael C Pirrung, Allyson Dorsey, Natalie De Howitt, Jiayu Liao
A 5,5-d2 -luciferin was prepared to measure isotope effects on reactions of two intermediates in firefly bioluminescence: emission by oxyluciferin and elimination of a putative luciferyl adenylate hydroperoxide to dehydroluciferin. A negligible isotope effect on bioluminescence provides further support for the belief that the emitting species is the keto-phenolate of oxyluciferin and rules out its excited-state tautomerization, one potential contribution to a bioluminescence quantum yield less than unity. A small isotope effect on dehydroluciferin formation supports a single-electron-transfer mechanism for reaction of the luciferyl adenylate enolate with oxygen to form the hydroperoxide or dehydroluciferin...
December 2017: ChemistryOpen
https://www.readbyqxmd.com/read/29226055/fluorescence-sensing-with-cellulose-based-materials
#20
REVIEW
Meng Li, Xiaoning Li, Hui-Ning Xiao, Tony D James
Cellulose-based materials functionalized with fluorescence sensors are highly topical and are employed in many areas of functional materials, including the sensing of heavy-metal ions and anions as well as being widely used as chemical sensors and tools for environmental applications. In this Review, we cover recent progress in the development of cellulose-based fluorescence sensors as parts of membranes and nanoscale materials for the detection of biological analytes. We believe that this Review will be of interest to chemists, chemical engineers, and biochemists in the sensor community as well as researchers working with biological material systems...
December 2017: ChemistryOpen
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