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Breast Cancer: Targets and Therapy

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https://www.readbyqxmd.com/read/28503075/imprint-cytology-versus-frozen-section-analysis-for-intraoperative-assessment-of-sentinel-lymph-node-in-breast-cancer
#1
Thalia Petropoulou, Antonia Kapoula, Aikaterini Mastoraki, Aikaterini Politi, Eleni Spanidou-Karvouni, Ioannis Psychogios, Ioannis Vassiliou, Nikolaos Arkadopoulos
INTRODUCTION: Sentinel lymph node (SLN) biopsy is the gold standard for surgical staging of the axilla in breast cancer (BC). Frozen section (FS) remains the most popular means of intraoperative SLN diagnosis. Imprint cytology (IC) has also been suggested as a less expensive and equally accurate alternative to FS. The aim of our study was to perform a direct comparison between IC and FS on the same SLNs of BC cases operated in a single center by the same surgical team. MATERIALS AND METHODS: Into this prospective study we enrolled 60 consecutive patients with histologically proven T1-T3 BC and clinically negative axilla...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28503074/acute-radiation-dermatitis-in-breast-cancer-patients-challenges-and-solutions
#2
REVIEW
Adam J Kole, Lauren Kole, Meena S Moran
Nearly all women who receive radiotherapy (RT) for breast cancer experience some degree of radiation dermatitis. However, evidence describing the appropriate management of radiation dermatitis is often lacking or contradictory. Here, we summarize the available literature regarding radiation dermatitis causes, the presentation and timing of symptoms, methods for dermatitis assessment and prevention, and review evidence-based management strategies.
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28496363/prognostic-value-of-histone-chaperone-fact-subunits-expression-in-breast-cancer
#3
Kristopher Attwood, Daria Fleyshman, Laura Prendergast, Geraldine Paszkiewicz, Angela R Omilian, Wiam Bshara, Katerina Gurova
Understanding the underlying reasons for tumor aggressiveness, such as why some tumors grow slowly and locally, while others rapidly progress to a lethal metastatic disease, is still limited. This is especially critical in breast cancer (BrCa) due to its high prevalence and also due to the possibility that it can be detected early. Several oncogenes and tumor suppressors have been identified and are used in the prognosis and treatment of BrCa. However, even with these markers, the outcome within BrCa subtypes is highly variable...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28496362/metaplastic-breast-carcinoma-with-upper-limb-gangrene
#4
Reynu Rajan, Norlia Abdullah, Nik Muhd Aslan Abdullah, Abdul Yazid Mohd Kassim
Metaplastic breast carcinomas (MBCs) are rapidly growing tumors with histological heterogeneity, and triple negative receptor status. The aim of this case report is to highlight a case of advanced MBC with axillary artery infiltration leading to gangrene of the ipsilateral upper limb, in a young woman.
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28496361/improved-immediate-breast-reconstruction-as-a-result-of-oncoplastic-multidisciplinary-meeting
#5
Mohsen M El Gammal, Maria Lim, Rajan Uppal, Richard Sainsbury
INTRODUCTION: The National Institute for Health and Clinical Excellence guidelines recommend that breast reconstruction should be available to all women undergoing mastectomy and discussed at the initial surgical consultation (2002, and updated 2009). The National Mastectomy and Breast Reconstruction Audit (2009) showed that 21% of mastectomy patients underwent immediate breast reconstruction (IBR) and 11% had delayed breast reconstruction (DBR). Breast reconstruction has been shown to have a positive effect on quality of life postmastectomy...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28490901/breast-cancer-and-amyloid-bodies-is-there-a-role-for-amyloidosis-in-cancer-cell-dormancy
#6
Gerald J Mizejewski
Breast cancer and Alzheimer's disease (AD) are major causes of death in older women. Interestingly, breast cancer occurs less frequently in AD patients than in the general population. Amyloidosis, the aggregation of amyloid proteins to form amyloid bodies, plays a central role in the pathogenesis of AD and other human neuropathies by forming intracellular fibrillary proteins. Contrary to popular belief, amyloidosis is a common occurrence in mammalian cells, and has recently been reported to be a natural physiological process in response to environmental stress stimulations (such as pH and temperature extremes, hypoxia, and oxidative stress)...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28458580/lymphoscintigraphy-detecting-alterations-of-upper-limb-lymphatic-flow-following-early-sentinel-lymph-node-biopsy-in-breast-cancer
#7
Almir Jose Sarri, Eduardo Tinois da Silva, Rene Aloisio da Costa Vieira, Katia Hiromoto Koga, Pedro Henrique Moriguchi Cação, Vitor Coca Sarri, Sonia Marta Moriguchi
PURPOSE: To evaluate early variations in lymphatic circulation of the arm pre- and post-sentinel lymph node biopsy (SLNB) and conservative breast surgery by lymphoscintigraphy (LS). PATIENTS AND METHODS: Between 2005 and 2012, 15 patients underwent LS before and after the SLNB (total=30 studies). The pre-SLNB study was considered the control. Early images within twenty minutes (dynamic and static images) and delayed images within ninety minutes of arms and armpits were acquired using a gamma camera...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28458579/mentha-arvensis-linn-mediated-green-silver-nanoparticles-trigger-caspase-9-dependent-cell-death-in-mcf7-and-mda-mb-231-cells
#8
Prajna Paramita Banerjee, Arindam Bandyopadhyay, Singapura Nagesh Harsha, Rudragoud S Policegoudra, Shelley Bhattacharya, Niranjan Karak, Ansuman Chattopadhyay
INTRODUCTION: Leaf extract of Mentha arvensis or mint plant was used as reducing agent for the synthesis of green silver nanoparticles (GSNPs) as a cost-effective, eco-friendly process compared to that of chemical synthesis. The existence of nanoparticles was characterized by ultraviolet-visible spectrophotometry, dynamic light scattering, Fourier transform infrared spectroscopy, X-ray diffraction, energy-dispersive X-ray analysis, atomic-force microscopy and transmission electron microscopy analyses, which ascertained the formation of spherical GSNPs with a size range of 3-9 nm...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28458578/intraoperative-radiation-therapy-for-breast-cancer-patients-current-perspectives
#9
REVIEW
Sunil W Dutta, Shayna L Showalter, Timothy N Showalter, Bruce Libby, Daniel M Trifiletti
Accelerated partial breast irradiation (APBI) provides an attractive alternative to whole breast irradiation (WBI) through normal tissue radiation exposure and reduced treatment duration. Intraoperative radiation therapy (IORT) is a form of APBI with the shortest time interval, as it delivers the entirety of a planned radiation course at the time of breast surgery. However, faster is not always better, and IORT has been met with healthy skepticism. Patients treated with IORT have an increased compliance and overall satisfaction when compared to patients treated with WBI...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28450788/effects-of-cyp2d6-and-cyp3a5-polymorphisms-on-tamoxifen-and-its-metabolites-in-thai-breast-cancer-patients
#10
Wanaporn Charoenchokthavee, Nutthada Areepium, Duangchit Panomvana, Virote Sriuranpong
PURPOSE: This study aimed to determine the effects of CYP2D6 and CYP3A5 polymorphisms on the levels of tamoxifen (TAM) and its metabolites in the plasma of breast cancer patients. The protocol was designed to test the associations between CYP2D6, CYP3A5 genotypes and phenotypes (extensive metabolizer [EM], intermediate metabolizer [IM] and poor metabolizer [PM]) and TAM, N-desmethyl tamoxifen (NDMT), endoxifen (END) and 4-hydroxytamoxifen (4OHT) concentrations. PATIENTS AND METHODS: One hundred and thirty-four Thai breast cancer patients from the Thai Tamoxifen Project undergoing TAM treatment who met the inclusion/exclusion criteria were recruited...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28442932/granular-cell-tumor-in-breast-a-case-report
#11
Maria Castillo Lara, Antonia Martínez Herrera, Rafael Torrejón Cardoso, Daniel Maria Lubián López
Granular cell tumor (GCT) is a rare neoplasm of the soft tissues, and <1% of all GCTs are malignant. It usually appears in the tongue and sometimes may affect the female breast. Initially, GCT was considered to be a myogenic lesion affecting female breast (myoblastoma). Actually, it is assumed as a tumor originating from perineural or putative Schwann cells of peripheral nerves or their precursors that grows in the lobular breast tissue, due to the immunohistochemical features. Here, we review the importance of differentiating between this tumor and malignant breast carcinoma...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28424560/an-exploratory-study-of-host-polymorphisms-in-genes-that-clinically-characterize-breast-cancer-tumors-and-pretreatment-cognitive-performance-in-breast-cancer-survivors
#12
Theresa A Koleck, Catherine M Bender, Beth Z Clark, Christopher M Ryan, Puja Ghotkar, Adam Brufsky, Priscilla F McAuliffe, Priya Rastogi, Susan M Sereika, Yvette P Conley
PURPOSE: Inspired by the hypothesis that heterogeneity in the biology of breast cancers at the cellular level may account for cognitive dysfunction symptom variability in survivors, the current study explored relationships between host single-nucleotide polymorphisms (SNPs) in 25 breast cancer-related candidate genes (AURKA, BAG1, BCL2, BIRC5, CCNB1, CD68, CENPA, CMC2, CTSL2, DIAPH3, ERBB2, ESR1, GRB7, GSTM1, MELK, MKI67, MMP11, MYBL2, NDC80, ORC6, PGR, RACGAP1, RFC4, RRM2, and SCUBE2), identified from clinically relevant prognostic multigene-expression profiles for breast cancer, and pretreatment cognitive performance...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28408853/tumescent-mastectomy-the-current-indications-and-operative-tips-and-tricks
#13
Ashraf Khater, Alaa Mazy, Mona Gad, Ola Taha Abd Eldayem, Mohamed Hegazy
BACKGROUND: Tumescent mastectomy refers to usage of a mixture of lidocaine and epinephrine in a diluting saline solution that makes flaps firm and tense, thus minimizing systemic drugs toxicity and making surgery possible with minimal bleeding. This technique is very useful in elder women and those with American Society of Anesthesiologists; score III and IV. The objective was to establish an alternative safe technique to general anesthesia in some selected mastectomy patients. PATIENTS AND METHODS: Twenty candidate women for total mastectomy and axillary dissection were enrolled and consented to participate...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28408852/the-role-of-the-chemokine-receptor-xcr1-in-breast-cancer-cells
#14
Xiao Li Yang, Li Guo Qi, Feng Juan Lin, Zhou Luo Ou
Considerable attention has recently been paid to the application of chemokines to cancer immunotherapy due to their complex role in cell proliferation, invasion, metastasis, and tumorigenesis, which extends beyond the regulation of lymphocyte migration during immune responses. The expression and the function of the chemokine receptor XCR1 on breast cancer have remained elusive to date. In this study, the expressions of XCR1 mRNA were tested by quantitative real-time polymerase chain reaction in one breast epithelial cell line (MCF-10A) and nine breast cancer cell lines (MDA-MB-231, 231HM, 231BO, MDA-MB-468, MCF-7, T47D, Bcap-37, ZR-75-30, and SK-BR-3)...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28392714/economic-analysis-of-the-breast-cancer-screening-program-used-by-the-uk-nhs-should-the-program-be-maintained
#15
REVIEW
Robert Morton, Meelad Sayma, Manraj Singh Sura
INTRODUCTION: One key tool thought to combat the spiraling costs of late-stage breast cancer diagnosis is the use of breast cancer screening. However, over recent years, more effective treatments and questions being raised over the safety implications of using mammography have led to the cost-effectiveness of breast cancer screening to be highlighted as an important issue to investigate. METHODS: A cost-utility analysis was conducted to appraise the breast cancer screening program...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28360536/intensity-modulated-radiation-therapy-for-early-stage-breast-cancer-is-it-ready-for-prime-time
#16
REVIEW
Tabitha Y Chan, Poh Wee Tan, Johann I Tang
Whole breast external beam radiotherapy (WBEBRT) is commonly used as an essential arm in the treatment management of women with early-stage breast cancer. Dosimetry planning for conventional WBEBRT typically involves a pair of tangential fields. Advancement in radiation technology and techniques has the potential to improve treatment outcomes with clinically meaningful long-term benefits. However, this advancement must be balanced with safety and improved efficacy. Intensity-modulated radiation therapy (IMRT) is an advanced technique that shows promise in improving the planning process and radiation delivery...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28356770/breast-cancer-in-patients-with-li-fraumeni-syndrome-a-case-series-study-and-review-of-literature
#17
Amara G Nandikolla, Sangeetha Venugopal, Jesus Anampa
BACKGROUND: Li-Fraumeni Syndrome (LFS) is a rare disease with autosomal dominant inheritance linked to germline mutations of tumor suppressor gene TP53. These patients are predisposed to malignancies such as sarcoma, breast cancer, leukemia, and other malignancies. Breast cancer, the most common malignancy in adult patients with LFS, has an early-onset presentation and is usually treated as per the guidelines for the general population due to the limited literature about breast cancer in LFS...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28356769/validation-of-health-behavior-and-stages-of-change-questionnaire
#18
Leivy Patricia Gonzalez-Ramirez, Jose Maria De la Roca-Chiapas, Cecilia Colunga-Rodriguez, Maria de Lourdes Preciado-Serrano, Adrian Daneri-Navarro, Francisco Javier Pedroza-Cabrera, Reyna Jazmin Martinez-Arriaga
BACKGROUND: The transtheoretical model (TTM) has been widely used to promote healthy behaviors in different groups. However, a questionnaire has not yet been developed to evaluate the health behaviors that medical practitioners often consider in individuals with cancer or at a high risk of developing cancer. PURPOSE: The aim of this study was to construct and validate the Health Behavior and Stages of Change Questionnaire (HBSCQ), which is based on the TTM and health recommendations related to risk and factors that protect against cancer...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28356768/drug-screening-and-genomic-analyses-of-her2-positive-breast-cancer-cell-lines-reveal-predictors-for-treatment-response
#19
Sandra Jernström, Vesa Hongisto, Suvi-Katri Leivonen, Eldri Undlien Due, Dagim Shiferaw Tadele, Henrik Edgren, Olli Kallioniemi, Merja Perälä, Gunhild Mari Mælandsmo, Kristine Kleivi Sahlberg
BACKGROUND: Approximately 15%-20% of all diagnosed breast cancers are characterized by amplified and overexpressed HER2 (= ErbB2). These breast cancers are aggressive and have a poor prognosis. Although improvements in treatment have been achieved after the introduction of trastuzumab and lapatinib, many patients do not benefit from these drugs. Therefore, in-depth understanding of the mechanisms behind the treatment responses is essential to find alternative therapeutic strategies. MATERIALS AND METHODS: Thirteen HER2 positive breast cancer cell lines were screened with 22 commercially available compounds, mainly targeting proteins in the ErbB2-signaling pathway, and molecular mechanisms related to treatment sensitivity were sought...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28352202/preexposure-of-mcf-7-breast-cancer-cell-line-to-dexamethasone-alters-the-cytotoxic-effect-of-paclitaxel-but-not-5-fluorouracil-or-epirubicin-chemotherapy
#20
Frederic Buxant, Nadège Kindt, Jean-Christophe Noël, Guy Laurent, Sven Saussez
PURPOSE: Glucocorticoids (GCs) are often administered prior to any chemotherapeutics to prevent the secondary effects of anticancer agents. Glucocorticoid receptors (GRs) are expressed in several types of cancer cells, particularly in several histological types of breast cancer. Activation of GRs is not associated with any specific cellular response. Both proapoptotic and antiapoptotic responses have been observed, depending on the study or the type of breast cancer cells. Therefore, it is of relevance to investigate the possible modulation of apoptotic effect of chemotherapeutic agents when cancerous cells have previously been exposed to GCs...
2017: Breast Cancer: Targets and Therapy
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