journal
MENU ▼
Read by QxMD icon Read
search

Breast Cancer: Targets and Therapy

journal
https://www.readbyqxmd.com/read/28223845/the-predictors-of-poor-quality-of-life-in-a-sample-of-saudi-women-with-breast-cancer
#1
Anwar E Ahmed, Abdulrahman G Alharbi, Mohannad A Alsadhan, Alaa S Almuzaini, Hanin S Almuzaini, Yosra Z Ali, Abdul-Rahman Jazieh
BACKGROUND: The protocols for treatment, along with many adverse effects, can strongly affect cancer patients' quality of life (QoL). As there is limited research on the QoL of Saudi Arabian women being treated for breast cancer, the purpose of this study was to identify the predictors of poor QoL in a sample of Saudi women with breast cancer. METHODS: A cross-sectional study was conducted on 145 Saudi women with breast cancer who attended the Oncology Outpatient Clinic at King Abdulaziz Medical City, Riyadh for routine follow-up...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28182136/reduction-in-breast-cancer-susceptibility-due-to-xbai-gene-polymorphism-of-alpha-estrogen-receptor-gene-in-jordanians
#2
Manar Fayiz Atoum, Foad Alzoughool
Breast cancer is a global health concern among women worldwide. Estrogen receptor alpha (ERα) mediates diverse polymorphic effects in breast tissues that may relate to breast cancer susceptibility. The aim of this study was to evaluate the effect of -397 PvuII (T/C) and -351 XbaI (A/G) restriction fragment length polymorphism within intron 1 of ERα, and its effect on breast cancer susceptibility. A total of 156 women who were histopathologically diagnosed with breast cancer and 142 healthy Jordanian women were enrolled in this case-control study...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28176956/docetaxel-associated-myalgia-arthralgia-syndrome-in-patients-with-breast-cancer
#3
Chelsea Seguin, Natalie Kovacevich, Ioannis A Voutsadakis
BACKGROUND: As taxanes are increasingly used in oncology, the myalgia-arthralgia syndrome (M-AS) that represents an adverse effect of these drugs is becoming more common. Nevertheless, information regarding predisposing factors, prevention, and therapy of the syndrome is still lacking. PATIENTS AND METHODS: Women who had received docetaxel as part of the FEC-D(T) regimen for the adjuvant treatment of breast cancer were retrospectively identified from the records of our oncology department...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28176935/breast-cancer-in-mongolia-an-increasingly-important-health-policy-issue
#4
REVIEW
Delgermaa Demchig, Claudia Mello-Thoms, Patrick C Brennan
Breast cancer is a leading cause of cancer-related death for women in both developed and developing countries. The incidence and mortality of breast cancer in Mongolia, while low compared with other counties, has been increasing on an annual basis. In addition, in Mongolia, approximately 90% of the patients are diagnosed at a late stage, resulting in high mortality, with the majority of individuals diagnosed with breast cancer dying within 5 years of diagnosis. Breast cancer screening plays an important role in reducing mortality in Western countries and has been adopted by a number of Asian countries; however, no such approach exists in Mongolia...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28144163/association-between-telomere-length-and-cyp19-ttta-repetition-polymorphism-in-healthy-and-breast-cancer-diagnosed-women
#5
Blanca Murillo-Ortiz, Sandra Martínez-Garza, David Suárez García, Rosa Del Carmen Castillo Valenzuela, Juan Francisco García Regalado, Gerardo Cano Velázquez
INTRODUCTION: Several studies have reported an increase in breast cancer (BC) risk when patients are carriers of the CYP19 TTA polymorphism with ≥10 repeats; moreover, it has been reported that telomere length is associated with a higher susceptibility of developing cancer. OBJECTIVE: The objective of this study was to understand the relationship between CYP19 TTTA repetition polymorphism and telomere length and its effects on serum estradiol, estrone and follicle-stimulating hormone (FSH)...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28096694/luteolin-inhibits-lung-metastasis-cell-migration-and-viability-of-triple-negative-breast-cancer-cells
#6
Matthew T Cook, Yayun Liang, Cynthia Besch-Williford, Salman M Hyder
Most breast cancer-related deaths from triple-negative breast cancer (TNBC) occur following metastasis of cancer cells and development of tumors at secondary sites. Because TNBCs lack the three receptors targeted by current chemotherapeutic regimens, they are typically treated with extremely aggressive and highly toxic non-targeted treatment strategies. Women with TNBC frequently develop metastatic lesions originating from drug-resistant residual cells and have poor prognosis. For this reason, novel therapeutic strategies that are safer and more effective are sought...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28096693/gastric-and-colon-metastasis-from-breast-cancer-case-report-review-of-the-literature-and-possible-underlying-mechanisms
#7
J Carlos Villa Guzmán, J Espinosa, R Cervera, M Delgado, R Patón, J M Cordero García
Gastrointestinal metastases from breast cancer are not common. We present a 58-year-old female diagnosed with lobular breast cancer some years before whose relapses were gastric and colonic mucosal. Simultaneous metastases are extremely rare. To our knowledge, no cases of initial dual affectation have been reported. The patient also showed gastritis by Helicobacter pylori. Invasive lobular breast carcinoma is the most frequent special type of breast cancer and carries some specific molecular alterations such as loss of expression of E-cadherin...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28008282/expression-and-functionality-of-trpv1-in-breast-cancer-cells
#8
Lea V Weber, Klaudia Al-Refae, Gerhard Wölk, Gabriele Bonatz, Janine Altmüller, Christian Becker, Günter Gisselmann, Hanns Hatt
Transient receptor potential (TRP) channels contribute to the regulation of intracellular calcium, which can promote cancer hallmarks in cases of dysregulation of gene transcription and calcium-dependent pro-proliferative or anti-apoptotic mechanisms. Several studies have begun to elucidate the roles of TRPV1, TRPV6, TRPM8, and TRPC1 in cancer progression; however, no study has examined the expression profiles of human TRP channels in breast cancer on a large scale. This study focused on the expression and functionality of TRPV1, a nonselective cation channel that was found to be expressed in different carcinoma tissues...
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27994484/role-of-natural-herbs-and-phytochemicals-to-minimize-tumor-and-economic-burden-in-breast-cancer-treatment
#9
COMMENT
Maria Shoaib, Syed Ahsanuddin Ahmed
No abstract text is available yet for this article.
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27994483/clinical-effects-of-prior-trastuzumab-on-combination-eribulin-mesylate-plus-trastuzumab-as-first-line-treatment-for-human-epidermal-growth-factor-receptor-2-positive-locally-recurrent-or-metastatic-breast-cancer-results-from-a-phase-ii-single-arm-multicenter
#10
Shannon Puhalla, Sharon Wilks, Adam M Brufsky, Joyce O'Shaughnessy, Lee S Schwartzberg, Erhan Berrak, James Song, Linda Vahdat
Eribulin mesylate, a novel nontaxane microtubule dynamics inhibitor in the halichondrin class of antineoplastic drugs, is indicated for the treatment of patients with metastatic breast cancer who previously received ≥2 chemotherapy regimens in the metastatic setting. Primary data from a Phase II trial for the first-line combination of eribulin plus trastuzumab in human epidermal growth factor receptor 2 positive patients showed a 71% objective response rate and tolerability consistent with the known profile of these agents...
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27920576/hmmr-antisense-rna-1-a-novel-long-noncoding-rna-regulates-the-progression-of-basal-like-breast-cancer-cells
#11
Wei Liu, Jun Ma, Yong Cheng, Hongbo Zhang, Wengguang Luo, Hongyan Zhang
Recently, accumulating evidence has suggested that long noncoding RNAs (lncRNAs) play crucial roles in carcinogenesis and cancer progression. Hyaluronan-mediated motility receptor (HMMR) is an essential cancer-related gene in basal-like breast cancer (BLBC). In our study, HMMR antisense RNA 1 (HMMR-AS1) was analyzed in BLBC patients through polymerase chain reaction analysis. Here, we found that the expression of HMMR was positively correlated with HMMR-AS1 (RP11-80G.1). When HMMR-AS1 (RP11-80G.1) was knocked down, the expression of HMMR markedly reduced...
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27895513/tumor-suppressor-ing4-inhibits-estrogen-receptor-activity-in-breast-cancer-cells
#12
Madeline M Keenen, Suwon Kim
Resistance to antiestrogen therapy remains a significant problem in breast cancer. Low expression of inhibitor of growth 4 (ING4) in primary tumors has been correlated with increased rates of recurrence in estrogen receptor-positive (ER+) breast cancer patients, suggesting a role for ING4 in ER signaling. This study provides evidence that ING4 inhibits ER activity. ING4 overexpression increased the sensitivity of T47D and MCF7 ER+ breast cancer cells to hormone deprivation. ING4 attenuated maximal estrogen-dependent cell growth without affecting the dose-response of estrogen...
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27895512/are-another-5-years-of-adjuvant-aromatase-inhibitor-therapy-needed
#13
COMMENT
Qin-Guo Mo, De-Quan Li, Jian-Hong Zhong, Chang-Yuan Wei
No abstract text is available yet for this article.
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27853392/statins-and-risk-of-breast-cancer-recurrence
#14
Minas Sakellakis, Karolina Akinosoglou, Anastasia Kostaki, Despina Spyropoulou, Angelos Koutras
BACKGROUND: The primary end point of our study was to test whether the concurrent use of a statin is related to a lower risk of recurrence and increased relapse-free survival in patients with early breast cancer. MATERIALS AND METHODS: We reviewed 610 female patients with stage I, II, or III breast cancer who had been surgically treated and who had subsequently received at least adjuvant chemotherapy in order to prevent recurrence. RESULTS: Among the 610 patients with breast cancer, 83 (13...
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27785100/current-advances-in-biomarkers-for-targeted-therapy-in-triple-negative-breast-cancer
#15
REVIEW
Brett Fleisher, Charlotte Clarke, Sihem Ait-Oudhia
Triple-negative breast cancer (TNBC) is a complex heterogeneous disease characterized by the absence of three hallmark receptors: human epidermal growth factor receptor 2, estrogen receptor, and progesterone receptor. Compared to other breast cancer subtypes, TNBC is more aggressive, has a higher prevalence in African-Americans, and more frequently affects younger patients. Currently, TNBC lacks clinically accepted targets for tailored therapy, warranting the need for candidate biomarkers. BiomarkerBase, an online platform used to find biomarkers reported in clinical trials, was utilized to screen all potential biomarkers for TNBC and select only the ones registered in completed TNBC trials through clinicaltrials...
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27785099/economic-burden-related-to-chemotherapy-related-adverse-events-in-patients-with-metastatic-breast-cancer-in-an-integrated-health-care-system
#16
Nazia Rashid, Han A Koh, Hilda C Baca, Kathy J Lin, Susan E Malecha, Anthony Masaquel
BACKGROUND: Breast cancer is treated with many different modalities, including chemotherapy that can be given as a single agent or in combination. Patients often experience adverse events from chemotherapy during the cycles of treatment which can lead to economic burden. OBJECTIVE: The objective of this study was to evaluate costs related to chemotherapy-related adverse events in patients with metastatic breast cancer (mBC) in an integrated health care delivery system...
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27621667/reducing-infection-risk-in-implant-based-breast-reconstruction-surgery-challenges-and-solutions
#17
REVIEW
Adrian Sh Ooi, David H Song
Implant-based procedures are the most commonly performed method for postmastectomy breast reconstruction. While donor-site morbidity is low, these procedures are associated with a higher risk of reconstructive loss. Many of these are related to infection of the implant, which can lead to prolonged antibiotic treatment, undesired additional surgical procedures, and unsatisfactory results. This review combines a summary of the recent literature regarding implant-related breast-reconstruction infections and combines this with a practical approach to the patient and surgery aimed at reducing this risk...
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27578997/prognostic-value-of-androgen-receptor-expression-in-triple-negative-breast-carcinomas-personal-experience-and-comments-on-a-review-about-triple-negative-breast-cancer-treatment-challenges-and-solutions-by-collignon-et-al
#18
Antonio Ieni, Valeria Barresi, Giuseppina Rosaria Rita Ricciardi, Barbara Adamo, Vincenzo Adamo, Giovanni Tuccari
No abstract text is available yet for this article.
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27540311/prevalence-of-cyp2d6-2-cyp2d6-4-cyp2d6-10-and-cyp3a5-3-in-thai-breast-cancer-patients-undergoing-tamoxifen-treatment
#19
Wanaporn Charoenchokthavee, Duangchit Panomvana, Virote Sriuranpong, Nutthada Areepium
BACKGROUND: Tamoxifen (TAM) is used in breast cancer treatment, but interindividual variabilities in TAM-metabolizing enzymes exist and have been linked to single nucleotide polymorphisms in the respective encoding genes. The different alleles and genotypes of these genes have been presented for Caucasians and Asians. This study aimed to explore the prevalence of the incomplete functional alleles and genotypes of the CYP2D6 and CYP3A5 genes in Thai breast cancer patients undergoing TAM treatment...
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27524919/adjuvant-systemic-therapy-in-older-women-with-breast-cancer
#20
REVIEW
Julieta Leone, Bernardo Amadeo Leone, José Pablo Leone
Breast cancer in the elderly is an increasing clinical problem. In addition, ~60% of deaths from breast cancer occur in women aged 65 years and older. Despite this, older women with breast cancer have been underrepresented in clinical trials, and this has led to less than optimal evidence to guide their therapy. The management of elderly women with early breast cancer is a complex process that requires careful evaluation of life expectancy, comorbidities, patient values, and risks and benefits of available treatment options...
2016: Breast Cancer: Targets and Therapy
journal
journal
47837
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"