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Breast Cancer: Targets and Therapy

journal
https://www.readbyqxmd.com/read/30410392/intracellular-aggregated-trpv1-is-associated-with-lower-survival-in-breast-cancer-patients
#1
Carlo Lozano, Claudio Córdova, Ivanny Marchant, Rodrigo Zúñiga, Paola Ochova, Ricardo Ramírez-Barrantes, Wilfredo Alejandro González-Arriagada, Belén Rodriguez, Pablo Olivero
Background: Breast cancer is a malignant disease that represents an important public health burden. The description of new molecular markers can be important to diagnosis, classification, and treatment. Transient receptor potential vanilloid 1 (TRPV1) polymodal channel is expressed in different neoplastic tissues and cell lines of breast cancer and associated with the regulation of tumor growth, tumor neurogenesis, cancer pain, and malignant progression of cancer. In primary and metastatic breast cancer tumors, TRPV1 is expressed during neoplastic transformation, invasive behavior, and resistance to cytotoxic therapy...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/30323659/psychological-symptoms-in-adult-saudi-arabian-cancer-patients-prevalence-and-association-with-self-rated-oral-health
#2
Anwar E Ahmed, Alhanouf N Albalawi, Eiman T Qureshey, Aisha T Qureshey, Nagarajkumar Yenugadhati, Hamdan Al-Jahdali, Abdul Rahman Jazieh
Background: Although psychological symptoms and oral health status are associated with health management and outcomes among cancer patients, their association has not been assessed in Saudi Arabia. We aimed to assess the symptoms of depression, anxiety, and stress and their association with their oral health status, adjusting for sociodemographic and clinical factors. Methods: A self-reported study included 375 adult cancer patients who received outpatient healthcare services in the Oncology Department, King Abdulaziz Medical City-Riyadh, Saudi Arabia, between April 1 and August 31, 2017...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/30323658/hypofractionated-radiotherapy-after-conservative-surgery-may-increase-low-intermediate-grade-late-fibrosis-in-breast-cancer-patients
#3
Cinzia Digesù, Francesco Deodato, Gabriella Macchia, Savino Cilla, Martina Pieri, Alice Zamagni, Andrea Farioli, Milly Buwenge, Gabriella Ferrandina, Alessio G Morganti
Aim: To compare late toxicity after postoperative hypofractionated radiotherapy (RT) and standard fractionated RT in patients with early-stage breast carcinoma. Methods: This retrospective study included 447 patients (Modulated Accelerated Radiotherapy [MARA-1]: 317 patients, and control group [CG]: 130 patients). In the CG, the whole breast received 50.4 Gy in 28 fractions (fx) using 3D-radiotherapy, plus a sequential electron boost (10 Gy in 4 fx) to tumor bed...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/30237735/anticancer-and-cardio-protective-effects-of-liposomal-doxorubicin-in-the-treatment-of-breast-cancer
#4
REVIEW
Yesenia L Franco, Tanaya R Vaidya, Sihem Ait-Oudhia
Breast cancer (BC) is a highly prevalent disease, accounting for the second highest number of cancer-related mortalities worldwide. The anthracycline doxorubicin (DOX), isolated from Streptomyces peucetius var. caesius , is a potent chemotherapeutic drug that is successfully used to treat various forms of liquid and solid tumors and is currently approved to treat BC. DOX exerts its effects by intercalation into DNA and inhibition of topoisomerases I and II, causing damage to DNA and the formation of reactive oxygen species (ROS), resulting in the activation of caspases, which ultimately leads to apoptosis...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/30087576/single-day-her2neu-amplification-assessment-using-chip-based-digital-pcr-in-formalin-fixed-paraffin-embedded-breast-carcinoma-tissue
#5
Parth S Shah, Shiva Murarka, Anupam Joshi, Bhavna Mehta, Vipal Parmar, Nidhi Shah, Khushbu Patel, Jacob Sands
Introduction: Human epidermal growth factor receptor 2 (HER2) amplification is present in almost 15%-20% of breast cancer tumors, making it an important parameter for testing. The present study was designed to evaluate a chip-based digital PCR (dPCR) system for assessing HER2 amplification from formalin-fixed paraffin-embedded breast carcinoma tissue and to compare this system with immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). Materials and methods: A total of 84 breast carcinoma tissue samples were analyzed by IHC, FISH, and chip-based dPCR in a blinded manner...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/30034251/evaluation-of-the-snapchat-mobile-social-networking-application-for-breast-cancer-awareness-among-saudi-students-in-the-dammam-region-of-the-kingdom-of-saudi-arabia
#6
Turki M Alanzi, Alanoud Alobrah, Reem Alhumaidi, Shahad Aloraifi
Purpose: The main aim of this study was to investigate the feasibility and the effectiveness of the SnapChat social networking mobile application in increasing the awareness of breast cancer among the Saudi female students in the Dammam region of Saudi Arabia. Patients and methods: An intervention study was carried out with 200 participants divided among 2 groups: a control group and an intervention group. The control group did not receive any awareness materials, and the intervention group received awareness about breast cancer through SnapChat using videos, texts, and pictures...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29950894/complexes-formed-by-mutant-p53-and-their-roles-in-breast-cancer
#7
REVIEW
Arianna Bellazzo, Daria Sicari, Elena Valentino, Giannino Del Sal, Licio Collavin
Breast cancer is the most frequently diagnosed malignancy in women, and mutations in the tumor suppressor p53 are commonly detected in the most aggressive subtypes. The majority of TP53 gene alterations are missense substitutions, leading to expression of mutant forms of the p53 protein that are frequently detected at high levels in cancer cells. P53 mutants not only lose the physiological tumor-suppressive activity of the wild-type p53 protein but also acquire novel powerful oncogenic functions, referred to as gain of function, that may actively confer a selective advantage during tumor progression...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29928143/mechanism-of-metastasis-suppression-by-luteolin-in-breast-cancer
#8
REVIEW
Matthew T Cook
Metastatic breast cancer is typically an extremely aggressive cancer with poor prognosis. Metastasis requires the orchestration of homeostatic factors and cellular programs, many of which are potential therapeutic targets. Luteolin (2-[3,4-dihydroxyphenyl]-5,7-dihydroxy-4-chromenone), is a naturally occurring flavonoid found in fruits and vegetables that exhibits many anticancer properties. Luteolin obstructs metastasis through both direct and indirect mechanisms. For instance, luteolin may suppress breast cancer invasion by acting as an antiangiogenic therapeutic inhibiting VEGF production and its receptor's activity...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29910635/impact-of-semaphorin-expression-on-prognostic-characteristics-in-breast-cancer
#9
REVIEW
Ramesh Butti, Totakura Vs Kumar, Ramakrishna Nimma, Gopal C Kundu
Breast cancer is one of the major causes of cancer-related deaths among women worldwide. Aberrant regulation of various growth factors, cytokines, and other proteins and their receptors in cancer cells drives the activation of various oncogenic signaling pathways that lead to cancer progression. Semaphorins are a class of proteins which are differentially expressed in various types of cancer including breast cancer. Earlier, these proteins were known to have a major function in the nerve cell adhesion, migration, and development of the central nervous system...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29765247/progression-free-survival-time-to-progression-as-a-potential-surrogate-for-overall-survival-in-hr-her2-metastatic-breast-cancer
#10
Anna Forsythe, David Chandiwana, Janina Barth, Marroon Thabane, Johan Baeck, Gabriel Tremblay
Background: Several recent randomized controlled trials (RCTs) in hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (MBC) have demonstrated significant improvements in progression-free survival (PFS); however, few have reported improvement in overall survival (OS). The surrogacy of PFS or time to progression (TTP) for OS has not been formally investigated in HR+, HER2- MBC. Methods: A systematic literature review of RCTs in HR+, HER2- MBC was conducted to identify studies that reported both median PFS/TTP and OS...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29606888/a-combination-of-p53-activating-apr-246-and-phosphatidylserine-targeting-antibody-potently-inhibits-tumor-development-in-hormone-dependent-mutant-p53-expressing-breast-cancer-xenografts
#11
Yayun Liang, Benford Mafuvadze, Cynthia Besch-Williford, Salman M Hyder
Background: Between 30 and 40% of human breast cancers express a defective tumor suppressor p53 gene. Wild-type p53 tumor suppressor protein promotes cell-cycle arrest and apoptosis and inhibits vascular endothelial growth factor-dependent angiogenesis, whereas mutant p53 protein (mtp53) lacks these functions, resulting in tumor cell survival and metastasis. Restoration of p53 function is therefore a promising drug-targeted strategy for combating mtp53-expressing breast cancer. Methods: In this study, we sought to determine whether administration of APR-246, a small-molecule drug that restores p53 function, in combination with 2aG4, an antibody that targets phosphatidylserine residues on tumor blood vessels and disrupts tumor vasculature, effectively inhibits advanced hormone-dependent breast cancer tumor growth...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29589598/erratum-profile-of-buparlisib-and-its-potential-in-the-treatment-of-breast-cancer-evidence-to-date-corrigendum
#12
(no author information available yet)
[This corrects the article on p. 23 in vol. 10, PMID: 29430197.].
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29551913/spotlight-on-triptorelin-in-the-treatment-of-premenopausal-women-with-early-stage-breast-cancer
#13
REVIEW
Marta Venturelli, Giorgia Guaitoli, Claudia Omarini, Luca Moscetti
Endocrine treatment represents the cornerstone of endocrine-sensitive premenopausal early breast cancer. The estrogen blockade plays a leading role in the therapeutic management of hormone receptor-positive breast cancer together with surgery, radiotherapy, and selective antiestrogen treatments. For several years, selective estrogen receptor modulators, such as tamoxifen, have represented the mainstay of therapy. The role of amenorrhea has been extensively elucidated in the past year: the benefit observed with chemotherapy-induced amenorrhea has strengthened its therapeutic role...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29445299/choosing-wisely-after-publication-of-level-i-evidence-in-breast-cancer-radiotherapy
#14
Joshua R Niska, Sameer R Keole, Barbara A Pockaj, Michele Y Halyard, Samir H Patel, Donald W Northfelt, Richard J Gray, Nabil Wasif, Carlos E Vargas, William W Wong
Background: Recent trials in early-stage breast cancer support hypofractionated whole-breast radiotherapy (WBRT) as part of breast-conserving therapy (BCT). Evidence also suggests that radiotherapy (RT) omission may be reasonable for some patients over 70 years. Among radiation-delivery techniques, intensity-modulated RT (IMRT) is more expensive than 3-dimensional conformal RT (3DCRT). Based on this evidence, in 2013, the American Society for Radiation Oncology (ASTRO) recommended hypofractionated schedules for women aged ≥50 years with early-stage breast cancer and avoiding routine use of IMRT for WBRT...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29430197/profile-of-buparlisib-and-its-potential-in-the-treatment-of-breast-cancer-evidence-to-date
#15
REVIEW
Carmen Criscitiello, Giulia Viale, Giuseppe Curigliano, Aron Goldhirsch
Alteration of the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin signaling pathway is key for the growth and survival of several cancers, including breast cancer. In addition, dysregulation of PI3K signaling may contribute to resistance to several anticancer agents. PI3K inhibitors may, therefore, be effective as antineoplastic therapy. Buparlisib is a potent and highly specific oral inhibitor of the pan-class I PI3K family. Buparlisib specifically inhibits class I PIK3 in the PI3K/AKT kinase signaling pathway in an ATP-competitive manner, thus inhibiting the production of the secondary messenger phosphatidylinositol (3,4,5)-trisphosphate and activation of the PI3K signaling pathway...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29416374/one-step-nucleic-acid-amplification-the-possible-value-in-assessing-sentinel-lymph-node-metastasis-during-mastectomy
#16
REVIEW
Alison E Hunter-Smith, Zenon Rayter
Breast cancer is the most common cancer in women, worldwide, and 1,400 deaths per day are attributed to it. The success of national screening programs has seen breast cancers being diagnosed at an earlier stage. With conservative surgery to the breast demonstrating equivalent long-term outcomes, the last 10 years have seen a growing interest in the safety of less invasive management for the axilla in breast cancer patients. One-step nucleic acid amplification (OSNA) is a validated, reliable, and efficient tool in identifying micro- and macro-metastases intraoperatively...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29403307/the-effects-of-black-cohosh-on-the-regulation-of-estrogen-receptor-er%C3%AE-and-progesterone-receptor-pr-in-breast-cancer-cells
#17
Monica Szmyd, Victoria Lloyd, Kelly Hallman, Katie Aleck, Viktoria Mladenovik, Christina McKee, Mia Morse, Tyler Bedgood, Sumi Dinda
The North American plant Cimicifuga racemosa , also known as black cohosh (BC), is a herb that recently has gained attention for its hormonal effects. As the usage of hormone replacement therapy is declining due to its adverse effects in women with cancer, many are turning to herbal remedies like BC to treat menopausal symptoms. It is crucial to determine whether the effects of BC involve estrogen receptor-alpha (ERα). Previous studies from our laboratory have shown ERα to be a possible molecular target for BC...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29263698/pleomorphic-lobular-carcinoma-is-it-more-similar-to-a-classic-lobular-cancer-or-to-a-high-grade-ductal-cancer
#18
Leopoldo Costarelli, Domenico Campagna, Alessandra Ascarelli, Francesco Cavaliere, Maria Helena Colavito, Tatiana Ponzani, Laura Broglia, Massimo La Pinta, Elena Manna, Lucio Fortunato
Background: Pleomorphic invasive lobular carcinoma (P-ILC) is an uncommon variety of invasive lobular carcinoma with aggressive clinical features. Little is described in the literature regarding this topic. Materials and methods: We reviewed our experiences from 2010 to 2015 and compared 40 patients with P-ILC, 126 patients with classic-ILC (C-ILC) and 574 cases of high-grade invasive ductal carcinoma (HG-IDC). We studied the histologic and immunohistochemical features, clinical presentation and surgical treatment...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29263697/recent-advances-of-cyclin-dependent-kinases-as-potential-therapeutic-targets-in-hr-her2-metastatic-breast-cancer-a-focus-on-ribociclib
#19
REVIEW
Dumessa Edessa, Mekonnen Sisay
In normal cell cycle progression, transition of G0/G1 phase to synthesis (S) phase for breast and other cells is regulated by association of cyclin D and cyclin-dependent kinases 4 and 6 (CDK4/6) that leads to phosphorylation of retinoblastoma (Rb) protein. Imbalance of this cyclin D-CDK4/6-inhibitors of CDK4/6-Rb phosphorylation pathway is associated with tumorigenesis of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancers. Despite effective first-line endocrine therapy, HR+/HER2- metastatic breast cancers remain still incurable...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29238220/effect-of-statins-on-breast-cancer-recurrence-and-mortality-a-review
#20
REVIEW
Renae D Van Wyhe, Omar M Rahal, Wendy A Woodward
Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are medications that have been used for decades to lower cholesterol and to prevent or treat cardiovascular diseases. Since their approval by the US Food and Drug Administration in the 1980s, other potential uses for statins have been speculated on and explored. Basic science and clinical research suggest that statins are also effective in the management of breast cancer. Specifically, in various breast cancer cell lines, statins increase apoptosis and radiosensitivity, inhibit proliferation and invasion, and decrease the metastatic dissemination of tumors...
2017: Breast Cancer: Targets and Therapy
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