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Breast Cancer: Targets and Therapy

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https://www.readbyqxmd.com/read/28331367/knowledge-attitudes-and-behaviors-of-primary-health-care-nurses-and-midwives-in-breast-cancer-early-diagnosis-applications
#1
Aliye Bulut, Aziz Bulut
PURPOSE: The purpose of this research was to analyze the knowledge, attitudes and behaviors of the nurses and midwives about the early diagnosis of breast cancer. MATERIALS AND METHODS: This cross-sectional study was carried out at 9 family medical centers (FMCs) and 1 community health center (CHC) in Bingol; the population of this research consisted of 25 midwives and 38 nurses. The protocol for this study was approved by the regional ethics committee of Bingol University...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28331366/the-effects-of-turmeric-curcumin-on-tumor-suppressor-protein-p53-and-estrogen-receptor-er%C3%AE-in-breast-cancer-cells
#2
Kelly Hallman, Katie Aleck, Brigitte Dwyer, Victoria Lloyd, Meghan Quigley, Nada Sitto, Amy E Siebert, Sumi Dinda
Curcumin (CUR) is a compound that has antibacterial, antiviral, anti-inflammatory, and anticancer properties. In this study, we have analyzed the effects of CUR on the expression of ERα and p53 in the presence of hormones and anti-hormones in breast cancer cells. Cells were cultured in a medium containing charcoal-stripped fetal bovine serum to deplete any endogenous steroids and treated with CUR at varying concentrations or in combination with hormones and anti-hormones. Protein analysis revealed a relative decrease in the levels of p53 and ERα upon treatment with 5-60 µM CUR...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28331365/mastectomy-skin-flap-necrosis-challenges-and-solutions
#3
REVIEW
Stuart A Robertson, Johann A Jeevaratnam, Avi Agrawal, Ramsey I Cutress
INTRODUCTION: Mastectomy skin flap necrosis (MSFN) has a reported incidence of 5%-30% in the literature. It is often a significant and underappreciated problem. The aim of this article was to review the associated challenges and possible solutions. METHODS: A MEDLINE search was performed using the search term "mastectomy skin flap necrosis". Titles and abstracts from peer-reviewed publications were screened for relevance. RESULTS: MSFN is a common complication and may present as partial- or full-thickness necrosis...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28331364/silicone-induced-granuloma-of-breast-implant-capsule-sigbic-similarities-and-differences-with-anaplastic-large-cell-lymphoma-alcl-and-their-differential-diagnosis
#4
REVIEW
Eduardo de Faria Castro Fleury, Milena Morais Rêgo, Luciana Costa Ramalho, Veronica Jorge Ayres, Rodrigo Oliveira Seleti, Carlos Alberto Pecci Ferreira, Decio Roveda
Primary breast lymphoma is a rare disease and accounts for 0.5% of cases of breast cancer. Most primary breast lymphomas develop from B cells, and the involvement of T cells is rare. Anaplastic large cell lymphoma (ALCL) is a recently discovered T-cell lymphoma associated with breast implants. Only a few cases have been reported to date. It is believed that the incidence of ALCL is increasing because of the increasing number of breast implants. The clinical presentation is variable and can manifest as a palpable mass in the breast or armpit, breast pain, or capsular contracture...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28331363/recent-insights-into-cigarette-smoking-as-a-lifestyle-risk-factor-for-breast-cancer
#5
REVIEW
Shannon Kispert, Jane McHowat
There have been many cohort studies published reviewing the epidemiological evidence that links breast cancer to cigarette smoking, yet the underlying mechanisms are largely unknown and research studies are few and incomplete. Although cohort studies are important in establishing a connection between breast cancer and cigarette smoking, basic science research is necessary to prove the relationship and to highlight potential interventions and drug targets that can be used to manage the disease. This subject has been controversial for many decades; however, there has been a recent resurgence in interest because of the widespread acknowledgment of the role lifestyle choices play in cancer development and progression...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28293119/intensity-modulated-radiation-therapy-for-breast-cancer-current-perspectives
#6
REVIEW
Milly Buwenge, Silvia Cammelli, Ilario Ammendolia, Giorgio Tolento, Alice Zamagni, Alessandra Arcelli, Gabriella Macchia, Francesco Deodato, Savino Cilla, Alessio G Morganti
BACKGROUND: Owing to highly conformed dose distribution, intensity modulated radiation therapy (IMRT) has the potential to improve treatment results of radiotherapy (RT). Postoperative RT is a standard adjuvant treatment in conservative treatment of breast cancer (BC). The aim of this review is to analyze available evidence from randomized controlled trials (RCTs) on IMRT in BC, particularly in terms of reduction of side effects. METHODS: A literature search of the bibliographic database PubMed, from January 1990 through November 2016, was performed...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28293118/cyp2d6-polymorphisms-may-predict-occurrence-of-adverse-effects-to-tamoxifen-a-preliminary-retrospective-study
#7
Ishani Wickramage, Kamani Hemamala Tennekoon, Merenchi Arachchige Yasantha Ariyaratne, Asanka Sudeshini Hewage, Tharmini Sundralingam
INTRODUCTION AND AIMS: Tamoxifen is an adjuvant drug effective in treating hormone receptor - positive breast cancer. However, 30%-50% of patients relapse and many develop adverse effects, such as hot flashes and fatty liver. Allelic variations altering the activity of cytochrome P450-2D6 enzyme affect response to tamoxifen by modulating metabolism of tamoxifen into its pharmacologically active metabolite endoxifen. Although association between CYP2D6 polymorphisms and recurrence of breast cancer in patients on tamoxifen had been reported, little evidence exists on association between these polymorphisms and adverse effects to tamoxifen...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28280388/alternative-therapies-for-metastatic-breast-cancer-multimodal-approach-targeting-tumor-cell-heterogeneity
#8
REVIEW
Manpreet Sambi, Sabah Haq, Vanessa Samuel, Bessi Qorri, Fiona Haxho, Kelli Hill, William Harless, Myron R Szewczuk
One of the primary challenges in developing effective therapies for malignant tumors is the specific targeting of a heterogeneous cancer cell population within the tumor. The cancerous tumor is made up of a variety of distinct cells with specialized receptors and proteins that could potentially be viable targets for drugs. In addition, the diverse signals from the local microenvironment may also contribute to the induction of tumor growth and metastasis. Collectively, these factors must be strategically studied and targeted in order to develop an effective treatment protocol...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28280387/ulva-lactuca-polysaccharides-prevent-wistar-rat-breast-carcinogenesis-through-the-augmentation-of-apoptosis-enhancement-of-antioxidant-defense-system-and-suppression-of-inflammation
#9
Gamal-Eldein F Abd-Ellatef, Osama M Ahmed, Eman S Abdel-Reheim, Abdel-Hamid Z Abdel-Hamid
BACKGROUND: Recently, several research studies have been focused on the isolation and function of the polysaccharides derived from different algal species, which revealed multiple biological activities such as antioxidant and antitumor activities. This study assesses the possible breast cancer chemopreventive properties of common seaweeds, sea lettuce, Ulva lactuca (ulvan) polysaccharides using in vitro bioassays on human breast cancer cell line (MCF-7) and an in vivo animal model of breast carcinogenesis...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28280386/nanomolar-concentration-of-blood-soluble-drag-reducing-polymer-inhibits-experimental-metastasis-of-human-breast-cancer-cells
#10
Zhijie Ding, Marion Joy, Marina V Kameneva, Partha Roy
Metastasis is the leading cause of cancer mortality. Extravasation of cancer cells is a critical step of metastasis. We report a novel proof-of-concept study that investigated whether non-toxic blood-soluble chemical agents capable of rheological modification of the near-vessel-wall blood flow can reduce extravasation of tumor cells and subsequent development of metastasis. Using an experimental metastasis model, we demonstrated that systemic administration of nanomolar concentrations of so-called drag-reducing polymer dramatically impeded extravasation and development of pulmonary metastasis of breast cancer cells in mice...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28280385/comment-on-gastric-and-colon-metastasis-from-breast-cancer-case-report-review-of-the-literature-and-possible-underlying-mechanisms
#11
COMMENT
Amin Talebi Bezmin Abadi
No abstract text is available yet for this article.
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28223845/the-predictors-of-poor-quality-of-life-in-a-sample-of-saudi-women-with-breast-cancer
#12
Anwar E Ahmed, Abdulrahman G Alharbi, Mohannad A Alsadhan, Alaa S Almuzaini, Hanin S Almuzaini, Yosra Z Ali, Abdul-Rahman Jazieh
BACKGROUND: The protocols for treatment, along with many adverse effects, can strongly affect cancer patients' quality of life (QoL). As there is limited research on the QoL of Saudi Arabian women being treated for breast cancer, the purpose of this study was to identify the predictors of poor QoL in a sample of Saudi women with breast cancer. METHODS: A cross-sectional study was conducted on 145 Saudi women with breast cancer who attended the Oncology Outpatient Clinic at King Abdulaziz Medical City, Riyadh for routine follow-up...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28182136/reduction-in-breast-cancer-susceptibility-due-to-xbai-gene-polymorphism-of-alpha-estrogen-receptor-gene-in-jordanians
#13
Manar Fayiz Atoum, Foad Alzoughool
Breast cancer is a global health concern among women worldwide. Estrogen receptor alpha (ERα) mediates diverse polymorphic effects in breast tissues that may relate to breast cancer susceptibility. The aim of this study was to evaluate the effect of -397 PvuII (T/C) and -351 XbaI (A/G) restriction fragment length polymorphism within intron 1 of ERα, and its effect on breast cancer susceptibility. A total of 156 women who were histopathologically diagnosed with breast cancer and 142 healthy Jordanian women were enrolled in this case-control study...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28176956/docetaxel-associated-myalgia-arthralgia-syndrome-in-patients-with-breast-cancer
#14
Chelsea Seguin, Natalie Kovacevich, Ioannis A Voutsadakis
BACKGROUND: As taxanes are increasingly used in oncology, the myalgia-arthralgia syndrome (M-AS) that represents an adverse effect of these drugs is becoming more common. Nevertheless, information regarding predisposing factors, prevention, and therapy of the syndrome is still lacking. PATIENTS AND METHODS: Women who had received docetaxel as part of the FEC-D(T) regimen for the adjuvant treatment of breast cancer were retrospectively identified from the records of our oncology department...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28176935/breast-cancer-in-mongolia-an-increasingly-important-health-policy-issue
#15
REVIEW
Delgermaa Demchig, Claudia Mello-Thoms, Patrick C Brennan
Breast cancer is a leading cause of cancer-related death for women in both developed and developing countries. The incidence and mortality of breast cancer in Mongolia, while low compared with other counties, has been increasing on an annual basis. In addition, in Mongolia, approximately 90% of the patients are diagnosed at a late stage, resulting in high mortality, with the majority of individuals diagnosed with breast cancer dying within 5 years of diagnosis. Breast cancer screening plays an important role in reducing mortality in Western countries and has been adopted by a number of Asian countries; however, no such approach exists in Mongolia...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28144163/association-between-telomere-length-and-cyp19-ttta-repetition-polymorphism-in-healthy-and-breast-cancer-diagnosed-women
#16
Blanca Murillo-Ortiz, Sandra Martínez-Garza, David Suárez García, Rosa Del Carmen Castillo Valenzuela, Juan Francisco García Regalado, Gerardo Cano Velázquez
INTRODUCTION: Several studies have reported an increase in breast cancer (BC) risk when patients are carriers of the CYP19 TTA polymorphism with ≥10 repeats; moreover, it has been reported that telomere length is associated with a higher susceptibility of developing cancer. OBJECTIVE: The objective of this study was to understand the relationship between CYP19 TTTA repetition polymorphism and telomere length and its effects on serum estradiol, estrone and follicle-stimulating hormone (FSH)...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28096694/luteolin-inhibits-lung-metastasis-cell-migration-and-viability-of-triple-negative-breast-cancer-cells
#17
Matthew T Cook, Yayun Liang, Cynthia Besch-Williford, Salman M Hyder
Most breast cancer-related deaths from triple-negative breast cancer (TNBC) occur following metastasis of cancer cells and development of tumors at secondary sites. Because TNBCs lack the three receptors targeted by current chemotherapeutic regimens, they are typically treated with extremely aggressive and highly toxic non-targeted treatment strategies. Women with TNBC frequently develop metastatic lesions originating from drug-resistant residual cells and have poor prognosis. For this reason, novel therapeutic strategies that are safer and more effective are sought...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28096693/gastric-and-colon-metastasis-from-breast-cancer-case-report-review-of-the-literature-and-possible-underlying-mechanisms
#18
J Carlos Villa Guzmán, J Espinosa, R Cervera, M Delgado, R Patón, J M Cordero García
Gastrointestinal metastases from breast cancer are not common. We present a 58-year-old female diagnosed with lobular breast cancer some years before whose relapses were gastric and colonic mucosal. Simultaneous metastases are extremely rare. To our knowledge, no cases of initial dual affectation have been reported. The patient also showed gastritis by Helicobacter pylori. Invasive lobular breast carcinoma is the most frequent special type of breast cancer and carries some specific molecular alterations such as loss of expression of E-cadherin...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28008282/expression-and-functionality-of-trpv1-in-breast-cancer-cells
#19
Lea V Weber, Klaudia Al-Refae, Gerhard Wölk, Gabriele Bonatz, Janine Altmüller, Christian Becker, Günter Gisselmann, Hanns Hatt
Transient receptor potential (TRP) channels contribute to the regulation of intracellular calcium, which can promote cancer hallmarks in cases of dysregulation of gene transcription and calcium-dependent pro-proliferative or anti-apoptotic mechanisms. Several studies have begun to elucidate the roles of TRPV1, TRPV6, TRPM8, and TRPC1 in cancer progression; however, no study has examined the expression profiles of human TRP channels in breast cancer on a large scale. This study focused on the expression and functionality of TRPV1, a nonselective cation channel that was found to be expressed in different carcinoma tissues...
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27994484/role-of-natural-herbs-and-phytochemicals-to-minimize-tumor-and-economic-burden-in-breast-cancer-treatment
#20
COMMENT
Maria Shoaib, Syed Ahsanuddin Ahmed
No abstract text is available yet for this article.
2016: Breast Cancer: Targets and Therapy
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