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Advanced Pharmaceutical Bulletin

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https://www.readbyqxmd.com/read/30276150/astaxanthin-rich-haematococcus-pluvialis-algal-hepatic-modulation-in-d-galactose-induced-aging-in-rats-role-of-nrf2
#1
Farouk Kamel El-Baz, Rehab Ali Hussein, Gehad Abdel Raheem Abdel Jaleel, Dalia Osama Saleh
Purpose: Aging is associated with hepatic morphological and physiological deterioration due to the accumulation of endogenous and exogenous free radicals and the resultant oxidative stress. The present study aims to investigate the effect of Haematococcus pluvialis microalgae on hepatic changes associated with D-galactose (D-Gal)-induced aging in rats. Methods: Aging was induced in rats by daily intraperitoneal injection of D-Gal (200 mg/kg/day) for eight consecutive weeks. D-Gal-injected rats were treated by astaxanthin (ATX)-rich H...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276149/presynaptic-activity-of-an-isolated-fraction-from-rhinella-schneideri-poison
#2
Sandro Rostelato-Ferreira, Cháriston André Dal Belo, Pedro Ismael da Silva Junior, Stephen Hyslop, Léa Rodrigues-Simioni, Thomaz Augusto Alves Rocha-E-Silva
Purpose: Rhinella schneideri is a toad found in many regions of the South America. The poison of the glands has cardiotoxic effect in animals and neuromuscular effects in mice and avian preparation. The purpose of this work was to identify the toxin responsible for the neuromuscular effect in avian and mice neuromuscular preparation. Methods: The methanolic extract from R. schneideri poison was fractioned by reversed phase HPLC. The purity and molecular mass were determined by LC/MS mass spectrometry. Chick biventer cervicis and mouse phrenic-nerve diaphragm were used as neuromuscular preparations to identify the toxin...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276148/the-cytotoxic-and-antimigratory-activity-of-brazilin-doxorubicin-on-mcf-7-her2-cells
#3
Riris Istighfari Jenie, Sri Handayani, Ratna Asmah Susidarti, Linar Zalinar Udin, Edy Meiyanto
Purpose: Breast cancer cells with overexpression of HER2 are known to be more aggressive, invasive, and resistant to chemotherapeutic agent. Brazilin, the major compound in the Caesalpinia sappan L. (CS) heartwood, has been studied for it's anticancer activity. The purpose of this study was to investigate the cytotoxic and antimigratory activity of brazilin (Bi) in combination with doxorubicin (Dox) on MCF-7/HER2 cells. Methods: Cytotoxic activities of Bi individually and in combination with Dox were examined by MTT assay...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276147/determining-abuse-deterrence-performance-of-poly-ethylene-oxide-using-a-factorial-design
#4
Yogesh Joshi, Srinath Muppalaneni, Alborz Omidian, David Jude Mastropietro, Hamid Omidian
Purpose: The purpose of this study was to determine the effects of thermal processing and antioxidant formulation variables on the abuse deterrence performance of a high molecular weight poly(ethylene oxide) (PEO) polymer. Methods: A 24 factorial design with one categorical factor (antioxidant type) and three continuous factors (curing time, curing temperature, % antioxidant) was used. Abuse deterrence performance was evaluated using solution viscosity, surface melting temperature, and mechanical strength. Thermal degradation of PEO powders before compaction was also studied using DSC, FTIR spectroscopy, and viscosity analysis...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276146/evaluation-of-npp1-as-a-novel-biomarker-of-coronary-artery-disease-a-pilot-study-in-human-beings
#5
Amir Hooshang Mohammadpour, Saeed Nazemi, Fatemeh Mashhadi, Atefeh Rezapour, Mohammad Afshar, Sepideh Afzalnia, Afsaneh Mohammadi, Hamid Reza Mashreghi Moghadam, Maryam Moradian, Seyed Mohammad Hasan Moallem, Saeed Falahaty, Azadeh Zayerzadeh, Sepideh Elyasi
Purpose: Coronary artery calcification (CAC) is utilized as an important tool for global risk assessment of cardiovascular events in individuals with intermediate risk. Ecto phosphodiesterase/nucleotide phosphohydrolase-1(ENPP1) converts extracellular nucleotides into inorganic pyrophosphate and it is a key regulator of tissue calcification that adjusts calcification in tissues like vascular smooth muscle cells. The main purpose of this clinical study was to find out the correlation between ENPP1 serum concentration and CAC in human for the first time...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276145/oleoylethanolamide-supplementation-reduces-inflammation-and-oxidative-stress-in-obese-people-a-clinical-trial
#6
Laleh Payahoo, Yaser Khajebishak, Mohammad Asghari Jafarabadi, Alireza Ostadrahimi
Purpose: Obesity as a serious public health problem worldwide, results in the incidence of many chronic diseases. Obesity has been recognized as a chronic low-grade inflammation disorder. Altered endocannabinoid system tone is also involved in the pathogenesis of obesity. The present study aimed to investigate the effects of oleoylethanolamide supplementation on inflammatory biomarkers and oxidative stress in obese people. Methods: This randomized, double-blind, placebo-controlled clinical trial was carried out on 60 healthy obese people in 2016 in Tabriz, Iran...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276144/impact-of-omega-3-supplementation-on-high-sensitive-c-reactive-protein-level-and-30-day-major-adverse-cardiac-events-after-the-implementation-of-coronary-stent-in-patients-with-chronic-kidney-disease-a-randomized-clinical-study
#7
Farzaneh Foroughinia, Bahram Movahed Nouri, Javad Kojuri, Mohammad Ali Ostovan
Purpose: Studies have revealed that patients with chronic kidney disease (CKD) are more susceptible to adverse effects of percutaneous coronary intervention (PCI). In addition, the role of elevated high sensitive C-reactive protein (hs-CRP) in the prediction of adverse cardiac outcomes after coronary stent implantation has already been shown. Therefore, in this study, we aimed to evaluate the effect of omega-3 supplementation on hs-CRP and 30-day major adverse cardiac events (MACE) in patients with CKD undergoing elective PCI...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276143/dual-preconditioning-a-novel-strategy-to-withstand-mesenchymal-stem-cells-against-harsh-microenvironments
#8
Hamed Bashiri, Fatemeh Amiri, Ali Hosseini, Masoud Hamidi, Amaneh Mohammadi Roushandeh, Yoshikazu Kuwahara, Mohammad Ali Jalili, Mehryar Habibi Roudkenar
Purpose: Poor survival rate of mesenchymal stem cells (MSCs) following their transplantation is one of the major challenges in their therapeutic application. Therefore, it is necessary to augment the viability of the MSCs in order to improve their therapeutic efficacy. Several strategies have been used to overcome this problem. Preconditioning of MSCs with oxidative stresses has gained a lot of attention. Therefore, in the present study, we investigated the effects of simultaneous preconditioning of MSCs with hydrogen peroxide and serum deprivation stresses on their survival and resistance to stressful conditions...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276142/mummy-material-can-promote-differentiation-of-adipose-derived-stem-cells-into-osteoblast-through-enhancement-of-bone-specific-transcription-factors-expression
#9
Maryam Eyvazi, Raheleh Farahzadi, Nahid Karimian Fathi, Mohammad Karimipour, Jafar Soleimani Rad, Azadeh Montaseri
Purpose: Application of Mummy material for treatment of different diseases such as bone fracture, cutaneous wounds and joint inflammation has been advised since hundred years ago in Persian traditional medicine. Due to the claims of indigenous people and advice of traditional medicine for application of this material in healing of bone fractures, this study has been designed to evaluate whether Mummy material can promote the differentiation of mesenchymal stem cells into osteoblasts and enhance the expression of bone specific genes and proteins...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276141/simulation-and-stability-assessment-of-anti-epcam-immunotoxin-for-cancer-therapy
#10
Seyed-Ali Hosseinian, Aliakbar Haddad-Mashadrizeh, Samaneh Dolatabadi
Purpose: Epithelial cell adhesion molecule (EpCAM) is a dominant antigen in human colon carcinoma tissue. Topology features of this antigen are different in normal and malignant conditions; for instance, EpCAM is much less accessible to antibodies in normal cells than in cancerous tissues. Hence, EpCAM has been considered as a suitable candidate for cancer target therapy via immunotoxins (ITs) development. In this study, attention was focused on the stability assessment of anti-EpCAM-IT (anti-Ep-IT) to design a novel IT...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276140/snail-1-silencing-by-sirna-inhibits-migration-of-te-8-esophageal-cancer-cells-through-downregulation-of-metastasis-related-genes
#11
Maryam Hemmatzadeh, Hamed Mohammadi, Farhad Babaie, Mehdi Yousefi, Mehrdad Ebrazeh, Behzad Mansoori, Dariush Shanehbandi, Behzad Baradaran
Purpose: Snail-1 is a transcription factor, which takes part in EMT, a process related to the emergence of invasion and cancer progression. The purpose of this study was to evaluate the effect of Snail-1 silencing on the human esophageal squamous cell carcinoma cell line, namely TE-8, in vitro. Methods: In this study, transfection of Snail-1 specific siRNA was conducted into TE-8 cells. The relative mRNA expression levels of Snail-1, Vimentin, CXCR4 and MMP-9 and transcription levels of miR-34a and let-7a were investigated by quantitative Real-time PCR...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276139/effect-of-ghrelin-on-caspase-3-and-bcl2-gene-expression-in-h2o2-treated-rat-s-bone-marrow-stromal-cells
#12
Alireza Abdanipour, Masoud Dadkhah, Mohsen Alipour, Hadi Feizi
Purpose: The antiapoptotic effect of ghrelin in various cell lines including bone marrow stromal cells (BMSCs) has been proved. However, the real mechanism of this effect is not clear. Caspase3 and Bcl2 are well-known pro- and antiapoptotic regulatory genes in eukaryotes. The aim of the study was to find out the effect of ghrelin on Caspase 3 and Bcl2 change in BMSCs. Methods: Rat BMSCs were cultivated in DMEM. Passage 3 BMSCs were treated with ghrelin 100 μM for 48 h. Real-time PCR for Caspase 3 and Bcl2 was carried out from B (untreated BMSCs), BH (BMSCs treated with 125 µM H2O2), BGH (BMSCs treated with 100 µM ghrelin then 125 µM H2O2) and BG (BMSCs treated with 100 µM ghrelin) groups...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276138/fabrication-and-characterization-of-gliclazide-nanocrystals
#13
Nagaraju Ravouru, Rajeswari Surya Anusha Venna, Subhash Chandra Bose Penjuri, Saritha Damineni, Venkata Subbaiah Kotakadi, Srikanth Reddy Poreddy
Purpose: The main aim of the present investigation was to enhance the solubility of poorly soluble Gliclazide by nanocrystallization. Methods: In present investigation gliclazide nanocrystals were prepared by sonoprecipitation using Pluronic F68, Poly Vinyl Alcohol (PVA), Poly ethylene Glycol 6000 (PEG), Poly Vinyl Pyrrolidine (PVP K30) and Sodium Lauryl Sulphate (SLS) as stabilizers. Fourier Transform Infrared Spectroscopic study (FTIR), Differential Scanning Calorimetry (DSC) and X ray diffraction (XRD) studies were conducted to study the drug interactions...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276137/enhanced-intestinal-permeation-of-doxorubicin-using-chitosan-nanoparticles
#14
Marziyeh Zare, Soliman Mohammadi Samani, Zahra Sobhani
Purpose: Due to limited oral bioavailability of doxorubicin (Dox) many efforts during the last decades focused on the development of novel delivery systems to overcome these limitations. In the present study, Dox encapsulated chitosan nanoparticles were prepared to evaluate the intestinal permeation of Dox via oral administration. Methods: Nanoparticles were fabricated based on ionic gelation method using tripolyphosphate. Some physicochemical properties, such as nanoparticle size and morphology, loading efficiency and in vitro drug release in 3 different pH values (5...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276136/comparison-of-pectin-layers-for-nicotine-transdermal-patch-preparation
#15
Jirapornchai Suksaeree, Jessada Prasomkij, Kamon Panrat, Wiwat Pichayakorn
Purpose: The objective of the present investigation was to prepare and evaluate transdermal patches for nicotine. Methods: Pectin isolated from the hulls of Monthong durian or leaves of Krueo Ma Noy was used as a matrix membrane for the controlled release of nicotine and compared with commercial pectin. The mechanical properties, moisture uptake, and Fourier transform infrared spectra were characterized. The in vitro stability of these patches was evaluated and compared to commercial nicotine patches. Results: The mechanical properties of the patches made from isolated pectin were greater than those prepared from commercial pectin; brittle commercial patches were obtained after nicotine loading...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276135/nanotechnology-in-wound-healing-semisolid-dosage-forms-containing-curcumin-ampicillin-solid-lipid-nanoparticles-in-vitro-ex-vivo-and-in-vivo-characteristics
#16
Solmaz Ghaffari, Faezeh Alihosseini, Seyed Mahdi Rezayat Sorkhabadi, Sepideh Arbabi Bidgoli, Seyyedeh Elaheh Mousavi, Setareh Haghighat, Ahoo Afshar Nasab, Nooshin Kianvash
Purpose: Wound healing is a natural biologic process, but the duration of it may take too long. Trying to shorten this process is one of the challenges for scientists. Many technologies were applied to achieve this goal as well as nanotechnology. In this study semi solid formulations containing curcumin and ampicillin solid lipid nanoparticles (SLNs) were prepared to evaluate as burn wound healing agent. Methods: Curcumin as an anti-inflammatory and anti-bacterial agent and ampicillin as an antibiotic were applied...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276134/targeted-co-delivery-of-docetaxel-and-cmet-sirna-for-treatment-of-mucin1-overexpressing-breast-cancer-cells
#17
Naime Majidi Zolbanin, Reza Jafari, Jafar Majidi, Fatemeh Atyabi, Mehdi Yousefi, Farhad Jadidi-Niaragh, Leili Aghebati-Maleki, Dariush Shanehbandi, Mohammad-Sadegh Soltani Zangbar, Alireza Mohajjel Nayebi
Purpose: Targeted treatment of breast cancer through combination of chemotherapeutic agents and siRNA had been drawing much attention in recent researches. This study was carried out to evaluate mucin1 aptamer-conjugated chitosan nanoparticles containing docetaxel and cMET siRNA on SKBR3 cells. Methods: Nano-drugs were characterized by transmission electron microscope, Zetasizer and loading efficiency calculation. siRNA entrapment onto nanoparticles, stability of siRNA-loaded nanoparticles and conjugation of mucin1 aptamer to nanoparticles were evaluated via separate electrophoresis...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276133/isotretinoin-a-review-on-the-utilization-pattern-in-pregnancy
#18
REVIEW
Sajad Khiali, Afshin Gharekhani, Taher Entezari-Maleki
Purpose: Isotretinoin is the most effective anti-acne drug with a long-term remission. However; it contains severe teratogenic effects with serious adverse drug reactions, which limits the use of medication. Methods: To review the use of isotretinoin during pregnancy, we carried out a comprehensive search of literature in Google Scholar, Scopus and PubMed/Medline from their inception until April 2015. Results: Database searching identified 277 records, of which, 38 articles were retrieved according to abstract and title assessment...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276132/natural-phytotherapeutic-antioxidants-in-the-treatment-of-mercury-intoxication-a-review
#19
REVIEW
Velid Unsal
Heavy metals taken into the organism can make the toxic effects on the metabolism in various ways. For example, they may interact with proteins to alter and inhibit their enzymatic and structural functions. Mercury is one of the toxic elements that are widely distributed in nature. Mercury toxicity poses a serious threat to human health. It is an element that causes oxidative stress to increase in individuals, leading to tissue damage. Oxidative stress is the result of the imbalance between the production of oxidative species and cellular antioxidant defense...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30276131/a-review-about-regulatory-status-and-recent-patents-of-pharmaceutical-co-crystals
#20
REVIEW
Arun Kumar, Sandeep Kumar, Arun Nanda
Pharmaceutical Co-crystals are not new, they have gained much attention since the last decade among scientists and pharmaceutical industry. Pharmaceutical co-crystals are multicomponent systems composed of two or more molecules and held together by non-covalent interactions. The development of pharmaceutical co-crystals, a new solid crystalline form, offer superior physico-chemical properties (such as melting point, stability, solubility, permeability, bioavailability, taste masking, etc.) without altering the pharmacological properties...
August 2018: Advanced Pharmaceutical Bulletin
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