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Advanced Pharmaceutical Bulletin

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https://www.readbyqxmd.com/read/29670852/a-molecular-study-on-drug-delivery-system-based-on-carbon-nanotube-compared-to-silicon-carbide-nanotube-for-encapsulation-of-platinum-based-anticancer-drug
#1
Zahra Khatti, Seyed Majid Hashemianzadeh, Seyed Ali Shafiei
Purpose: Drug delivery has a critical role in the treatment of cancer, in particular, carbon nanotubes for their potential use in various biomedical devices and therapies. From many other materials which could be more biocompatible and biodegradable and which could form single-walled nanotubes, silicon carbide was selected. Methods: To compare two drug delivery systems based on single-walled nanotubes, molecular dynamic simulations were applied and encapsulation behavior of the drug carboplatin was investigated inside the silicon carbide nanotube and the carbon nanotube...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670851/determination-and-quantification-of-the-vinblastine-content-in-purple-red-and-white-catharanthus-roseus-leaves-using-rp-hplc-method
#2
Rohanizah Abdul Rahim, Nor Hazwani Ahmad, Khaldun Mohammad Al Azzam, Ishak Mat
Purpose: To determine and quantify vinblastine in different varieties of Catharanthus roseus using reversed-phase HPLC method. Methods: The liquid chromatographic separation was performed using a reversed phase C18, Microsorb - MV column (250 mm x 4.6 mm, 5 µm) at room temperature and eluted with a mobile phase containing methanol - phosphate buffer (5 mM, pH 6.0) - acetonitrile with different proportion gradient elution at a flow rate of 2.0 mL min-1 and detection at 254 nm. Results: The HPLC method was utilized for the quantification of vinblastine in purple, red and white varieties of Catharanthus roseus leaves...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670850/green-synthesis-of-carbon-dots-derived-from-walnut-oil-and-an-investigation-of-their-cytotoxic-and-apoptogenic-activities-toward-cancer-cells
#3
Elham Arkan, Ali Barati, Mohsen Rahmanpanah, Leila Hosseinzadeh, Samaneh Moradi, Marziyeh Hajialyani
Purpose: This paper introduces a green and simple hydrothermal synthesis to prepare carbon quantum dots (CQDs) from walnut oil with a high quantum yield. In addition, cytotoxic and apoptogenic properties of the CQDs were analyzed on human cancer cell lines. Methods: The optical properties and morphological characteristic were investigated by the TEM, XRD, FT-IR, UV-vis and photoluminescence (PL).The cytotoxic potential of walnut CQDs was evaluated on PC3, MCF-7 and HT-29 human carcinoma cell lines using the MTT methods...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670849/ameliorative-activity-of-ethanolic-extract-of-artocarpus-heterophyllus-stem-bark-on-alloxan-induced-diabetic-rats
#4
Basiru Olaitan Ajiboye, Oluwafemi Adeleke Ojo, Oluwatosin Adeyonu, Oluwatosin Imiere, Babatunji Emmanuel Oyinloye, Oluwafemi Ogunmodede
Purpose: Diabetes mellitus is one of the major endocrine disorders, characterized by impaired insulin action and deficiency. Traditionally, Artocarpus heterophyllus stem bark has been reputably used in the management of diabetes mellitus and its complications. The present study evaluates the ameliorative activity of ethanol extract of Artocarpus heterophyllus stem bark in alloxan-induced diabetic rats. Methods: Diabetes mellitus was induced by single intraperitoneal injection of 150 mg/kg body weight of alloxan and the animals were orally administered with 50, 100 and 150 mg/kg body weight ethanol extract of Artocarpus heterophyllus stem bark once daily for 21 days...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670848/-teucrium-polium-extract-enhances-the-anti-angiogenesis-effect-of-tranilast-on-human-umbilical-vein-endothelial-cells
#5
Fatemeh Sheikhbahaei, Mozafar Khazaei, Seyed Noureddin Nematollahi-Mahani
Purpose: Angiogenesis plays an important role in numerous pathophysiological events like cancer. As a result of this, tranilast as an anti-fibrotic drug induces the promising antitumor activities through the inhibition of angiogenesis. Further, Teucrium polium (TP) is a herbal medicine (family Lamaceae) with antitumor properties. This study was conducted to investigate the combination effects of tranilast and T. polium on human umbilical vein endothelial cells (HUVECs) viability and apoptotic genes expression...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670847/changes-of-insulin-resistance-and-adipokines-following-supplementation-with-glycyrrhiza-glabra-l-extract-in-combination-with-a-low-calorie-diet-in-overweight-and-obese-subjects-a-randomized-double-blind-clinical-trial
#6
Mohammad Alizadeh, Nazli Namazi, Elham Mirtaheri, Nafiseh Sargheini, Sorayya Kheirouri
Purpose: Adipose tissue is a highly active endocrine organ which plays a key role in energy homeostasis. The aim of this study was to determine the effects of dried licorice extract along with a calorie restricted diet on body composition, insulin resistance and adipokines in overweight and obese subjects. Methods: Sixty-four overweight and obese volunteers (27 men, 37 women) were recruited into this double-blind, placebo-controlled, randomized, clinical trial. Participants were randomly allocated to the Licorice (n=32) or the placebo group (n=32), and each group received a low-calorie diet with either 1...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670846/evaluation-of-volatile-profile-fatty-acids-composition-and-in-vitro-bioactivity-of-tagetes-minuta-growing-wild-in-northern-iran
#7
Farshid Rezaei, Rashid Jamei, Reza Heidari
Purpose: The aim of the present study was to investigate the chemical properties of wild Tagetes minuta L. (family Astreacea) collected from Northern Iran during the flowering period concerning the chemical combination of the essential oil along with its antioxidant properties and composition of fatty acids. Methods: The essential oil of the plant was extracted by a Clevenger approach and analyzed using gas chromatography-mass spectroscopy (Capillary HP-5ms GC/MS Column). Fatty acid contents of this species as a result of hexane extraction were analyzed by means of gas chromatography (GC-FID) while their phenolic contents were analyzed by high performance liquid chromatography (HPLC-UV)...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670845/chemical-rheological-and-nutritional-characteristics-of-sesame-and-olive-oils-blended-with-linseed-oil
#8
Fataneh Hashempour-Baltork, Mohammadali Torbati, Sodeif Azadmard-Damirchi, Geoffrey Peter Savage
Purpose: Nutritional quality and oxidation stability are two main factors in the evaluation of edible oils. Oils in their pure form do not have an ideal fatty acid composition or suitable oxidative stability during processing or storage. Methods: This study was designed to evaluate the chemical, nutritional and rheological properties of oil mixtures in three ratios of olive: sesame: linseed, 65:30:5; 60:30:10 and 55:30:15. Acidity value, peroxide value, rancimat test, fatty acid profile, nutritional indexes and rheological properties of the oil blends were determined...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670844/the-eeffect-of-metformin-combined-with-calcium-vitamin-d-3-against-diet-induced-nonalcoholic-fatty-liver-disease
#9
Sara Shojaei Zarghani, Samin Abbaszadeh, Mohammad Alizadeh, Maryam Rameshrad, Alireza Garjani, Hamid Soraya
Purpose: Metformin is one of the most popular drugs tested against nonalcoholic fatty liver disease (NAFLD). The present study aimed to investigate whether calcium-vitamin D3 cosupplementation will intensify the effect of metformin on the prevention of high-fat, high-fructose (HFFr) diet-induced hepatic steatosis. Methods: Male wistar rats (210±16 g) were assigned into the following seven groups: a Control group to receive a standard chow and six HFFr-fed groups to receive diets containing either normal (0...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670843/bacteriophage-isolated-from-sewage-eliminates-and-prevents-the-establishment-of-escherichia-coli-biofilm
#10
Karla Veloso Gonçalves Ribeiro, Cleberson Ribeiro, Roberto Sousa Dias, Silvia Almeida Cardoso, Sergio Oliveira de Paula, Jose Cola Zanuncio, Leandro Licursi de Oliveira
Purpose: Biofilm growth exerts a negative impact on industry and health, necessitating the development of strategies to control. The objective of this work was study the lytic activity of the phage isolated from the sewage network in the formation and degradation of Escherichia coli biofilms. Methods: E. coli cultures were incubated in 96-well polystyrene microplates under controlled conditions to evaluate the biofilm formation. The E. coli cultures and established biofilms were treated with the suspensions of the vB_EcoM-UFV017 (EcoM017) bacteriophage obtained from sewage for 24 hours...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670842/investigation-of-effective-parameters-on-size-of-paclitaxel-loaded-plga-nanoparticles
#11
Fatemeh Madani, Seyedeh Sara Esnaashari, Basil Mujokoro, Farid Dorkoosh, Masood Khosravani, Mahdi Adabi
Purpose: The size of polymeric nanoparticles is considered as an effective factor in cancer therapy due to enterance into tumor tissue via the EPR effect. The purpose of this work was to investigate the effective parameters on poly(lactic-co-glycolic acid)-paclitaxel (PLGA -PTX) nanoparticles size. Methods: We prepared PLGA-PTX nanoparticles via single emulsion and precipitation methods with variable paremeters including drug concentration, aqueous to organic phase volume ratio, polymer concentration, sonication time and PVA concentration...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670841/effect-of-onopordon-acanthium-l-as-add-on-antihypertensive-therapy-in-patients-with-primary-hypertension-taking-losartan-a-pilot-study
#12
Roshanak Ghods, Manouchehr Gharouni, Massoud Amanlou, Niusha Sharifi, Ali Ghobadi, Gholamreza Amin
Purpose: Onopordon acanthium L. is known for its medicinal properties. Our recent study showed that its seed extract is a novel natura angiotensin-converting-enzyme inhibitor (ACEI). This study was carried out to investigate its possible antihypertensive effects in patients receiving losartan. Methods: This uncontrolled clinical trial was carried out among 20 patients (30-60y) with uncontrolled hypertension despite receiving 50 mg losartan (stage I & II) in two hospitals in Iran. After completing informed consent, patients were treated by 2 capsules [each 1g of Onopordon acanthium seed extract (OSE)] as add-on therapy, two times per day...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670840/investigating-effect-of-rapamycin-and-metformin-on-angiogenesis-in-hepatocellular-carcinoma-cell-line
#13
Mandana Rastegar, Haji-Amin Marjani, Yaghoub Yazdani, Majid Shahbazi, Masoud Golalipour, Touraj Farazmandfar
Purpose: Human hepatocellular carcinoma is one of the most common causes of death in the world. Metformin and rapamycin may decrease the expression of VEGF protein and subsequently angiogenesis. The purpose of this study was to evaluate the effect of these two drugs on expression of VEGF protein and the cell proliferation in the hepatocellular carcinoma cell line (ATCC HB-8065). Methods: HepG2 was cultured in RPMI-1640 medium at 37°C for 48h as a pre-culture and then treated by different concentrations of metformin (0, 5, 10 and 20 mM) and rapamycin (0, 5, 10 and 20 nM) at different times (12, 24 and 48 h)...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670839/effects-of-postconditioning-with-fructose-on-arrhythmias-and-the-size-of-infarct-caused-by-global-ischemia-and-reperfusion-in-isolated-rat-heart
#14
Jila Haghi, Tahereh Eteraf-Oskouei, Moslem Najafi
Purpose: In the present study, postconditioning effect of fructose against ischemia/reperfusion (I/R)-induced arrhythmias and infarct size were investigated in isolated rat heart. Methods: The isolated hearts were divided into 7 groups, mounted on a Langendorff apparatus at constant pressure then subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. In the control group, normal Krebs-Henseleit (K/H) solution was perfused into the hearts throughout the experiment. In two separate sets of experiments, the treatment groups received 12, 24 and 48 mM of fructose with/without normal glucose in K/H solution for 20 min at the beginning of reperfusion...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670838/novel-combination-of-silver-nanoparticles-and-carbon-nanotubes-for-plasmonic-photo-thermal-therapy-in-melanoma-cancer-model
#15
Mohammad Ali Behnam, Farzin Emami, Zahra Sobhani, Omid Koohi-Hosseinabadi, Amir Reza Dehghanian, Seyed Mojtaba Zebarjad, Mohammad Hadi Moghim, Ahmad Oryan
Purpose: Plasmonic photo thermal therapy (PPTT) is a therapeutic method in which the photon energy is rapidly transformed into heat via a series of radiative and non-radiative phenomena to ablate cancer. Plasmonic NPs, such as silver NPs (Ag NPs), have considerable properties in optical absorbance. Furthermore, good thermal conductivity and cell penetration ability of carbon nanotubes (CNTs) could improve the efficacy of Ag NPs for PPTT. Decoration of the multi-walled carbon nanotubes (MWCNTs) with silver has been developed to enhance thermal conductivity of the MWCNT particles...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670837/assessing-the-effect-of-high-performance-inulin-supplementation-via-klf5-mrna-expression-in-adults-with-type-2-diabetes-a-randomized-placebo-controlled-clinical-trail
#16
Abed Ghavami, Neda Roshanravan, Shahriar Alipour, Meisam Barati, Behzad Mansoori, Faezeh Ghalichi, Elyas Nattagh-Eshtivan, Alireza Ostadrahimi
Purpose: The worldwide prevalence of metabolic disorders such as diabetes is increasing rapidly. Currently, the complications of diabetes are the major health concern. The aim of this study was to investigate the effect of high performance (HP) inulin supplementation on glucose homeostasis via KLF5 mRNA expression in adults with type 2 diabetes. Methods: In the present clinical trial conducted for a duration of 6 weeks, 46 volunteers diabetic patients referring to diabetes clinic in Tabriz, Iran, were randomly assigned into intervention (n= 23, consuming 10 gr/d HP inulin) and control groups (n= 23, consuming 10 gr/ d starch)...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670836/construction-and-development-of-a-cardiac-tissue-specific-and-hypoxia-inducible-expression-vector
#17
Shahrooz Ghaderi, Neda Alidadiani, Jafar Soleimani Rad, Hamid Reza Heidari, Nafi Dilaver, Behzad Mansoori, Reza Rhabarghazi, Rezayat Parvizi, Vahid Khaze Shahgoli, Behzad Baradaran
Purpose: Cardiovascular gene therapy is a sophisticated approach, thanks to the safety of vectors, stable transgene expression, delivery method, and different layers of the heart. To date, numerous expression vectors have been introduced in biotechnology and biopharmacy industries in relation to genetic manipulation. Despite the rapid growth of these modalities, they must be intelligently designed, addressing the cardiac-specific transgene expression and less side effects. Herein, we conducted a pilot project aiming to design a cardiac-specific hypoxia-inducible expression cassette...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670835/preparation-of-the-potential-ocular-inserts-by-electrospinning-method-to-achieve-the-prolong-release-profile-of-triamcinolone-acetonide
#18
Shahla Mirzaeei, Kaveh Berenjian, Rasol Khazaei
Purpose: The poor bioavailability of drugs in the ocular delivery systems is an important issue and development of delivery systems with prolonged release profile could be in a major importance. This study aims to develop an ocular delivery system using electrospun nanofibers to be a candidate insert for delivery of triamcinolone acetonide. Methods: For this purpose, three different chitosan-based formulations were prepared by electrospinning method, and electrospun nanofibers were compared to a formulation comprising hydrophobic polymers (Eudragit S100 and Zein)...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670834/hybrid-scaffolds-of-hyaluronic-acid-and-collagen-loaded-with-prednisolone-an-interesting-system-for-osteoarthritis
#19
Farhad Mohammadi, Soliman Mohammadi Samani, Nader Tanideh, Fatemeh Ahmadi
Purpose: Cartilage regeneration by using polymeric scaffolds is a new option for treatment of osteoarthritis. A good scaffold for tissue engineering should copy the characteristics of natural extracellular matrix. The purpose of this study was to make a dosage form with proper reliability and stability for cartilage repair. Methods: Hybrid scaffolds containing different ratios of hyaluronic acid (HA) and collagen were prepared and loaded with prednisolone as anti-inflammatory agent. Two different dosage forms (lyophilized implantable disk and thermo-sensitive gels) were examined...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670833/interaction-of-coenzyme-q10-with-liposomes-and-its-impact-on-suppression-of-selenite-induced-experimental-cataract
#20
Medhat Wahba Shafaa, Amany Hasan Elshazly, Amira Zaki Dakrory, Maha Reda Elsyed
Purpose: To stress the influence of Coenzyme Q10 (CoQ10) on the structural properties of liposomes as model membranes and to investigate the possible role of CoQ10 or CoQ10 doped in liposomes when topically instilled as eye drops, in preventing cataract. Methods: The molecular interaction between liposomes and Coenzyme Q10 was examined using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). Rat pups were randomly divided into six groups comprising 15 pups. Group (1), control group...
March 2018: Advanced Pharmaceutical Bulletin
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