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Advanced Pharmaceutical Bulletin

Monica Budău, Gabriel Hancu, Aura Rusu, Melania Cârcu-Dobrin, Daniela Lucia Muntean
[This corrects the article DOI: 10.15171/apb.2017.061.].
June 2018: Advanced Pharmaceutical Bulletin
Ata Mahmoodpoor, Mahsa Medghalchi, Hossein Nazemiyeh, Parina Asgharian, Kamran Shadvar, Hadi Hamishehkar
Purpose: Cucurbita maxima Duchense (C. maxima) has been widely used in China and Mexico as a hypoglycemic plant for controlling blood glucose in diabetic patients. Furthermore, in northwest of Iran, this plant is used traditionally for controlling of diabetes. We examined the effect of C. maxima pulp besides insulin on control of hyperglycemia in diabetic patients admitted to Intensive care unit (ICU). Methods: Twenty critically ill patients who were admitted to the ICU were enrolled in this study. 5g lyophilized powder of C...
June 2018: Advanced Pharmaceutical Bulletin
Yousef Sohrabi, Hossein Mohammadzadeh-Aghdash, Elham Baghbani, Parvin Dehghan, Jafar Ezzati Nazhad Dolatabadi
Purpose: Ascorbyl palmitate (AP) is a widely used food additive in food industry. In this study, AP was evaluated for potential cyto-genotoxicity on Human Umbilical Vein Endothelial Cells (HUVECs). Methods: MTT assay and flow cytometry analysis was used for cytotoxicity evaluation, while genotoxicity was carried out using DAPI staining assays and real time PCR. Results: The growth of HUVECs was decreased upon treatment with AP in dose-and time-dependent manner. Early/late apoptosis percentage in HUVECs treated with this additive was detected using flow cytometry analysis...
June 2018: Advanced Pharmaceutical Bulletin
Hojatolla Nikravesh, Mohammad Javad Khodayar, Masoud Mahdavinia, Esrafil Mansouri, Leila Zeidooni, Fereshteh Dehbashi
Purpose: Gemfibrozil (GEM) apart from agonist activity at peroxisome proliferator-activated receptor-alpha (PPAR-α) has antioxidant and anti-inflammatory properties. Accordingly, the present study was designed to investigate the protective effect of GEM on acute liver toxicity induced by acetaminophen (APAP) in mice. Methods: In this study, mice divided in seven groups include, control group, APAP group, GEM group, three APAP groups pretreated with GEM at the doses of 25, 50 and 100 mg/kg respectively and APAP group pretreated with N-Acetyl cysteine...
June 2018: Advanced Pharmaceutical Bulletin
Goltaj Bayrami, Alireza Alihemmati, Pouran Karimi, Aniseh Javadi, Rana Keyhanmanesh, Mustafa Mohammadi, Milad Zadi-Heydarabad, Reza Badalzadeh
Purpose: Diabetic hearts are resistant to cardioprotection by ischemic-postconditioning (IPostC). Protection of diabetic hearts and finding related interfering mechanisms would have clinical benefits. This study investigated the combination effects of vildagliptin (Vilda) and IPostC on cardioprotection and the levels of autophagy and mitochondrial function following myocardial ischemia/reperfusion (I/R) injury in type-II diabetic rats. Methods: Diabetes was established by high fat diet/low dose of streptozotocin and lasted for 12 weeks...
June 2018: Advanced Pharmaceutical Bulletin
Somayyeh Asghari, Maryam Rafraf, Laleh Farzin, Mohammad Asghari-Jafarabadi, Seyed-Mostafa Ghavami, Mohammad-Hossein Somi
Purpose: Despite a proposed role for oxidative stress in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), antioxidant approaches have not been sufficiently investigated in human NAFLD management. Resveratrol has been reported to possess a wide range of biological functions, including antioxidant activities. This study aimed to evaluate the effects of resveratrol supplementation on oxidative/anti-oxidative status in patients with NAFLD. Methods: This randomized, double-blind, placebo-controlled clinical trial was conducted on 60 patients with NAFLD (males and females) aged 20 to 60 years, and body mass index (BMI) of 25-35 kg/m2...
June 2018: Advanced Pharmaceutical Bulletin
Sorayya Jacer, Hajar Shafaei, Jafar Soleimani Rad
Purpose: Adipose tissue derived stem cells (ASCs) and chondrocytes are best cells for articular cartilage regeneration. Chondrocyte with peri-cellular matrix (PCM) is called chondron provides ideal microenviroment than chondrocytes. We aimed to evaluate the regenerative effects of intra-articular injection of ASCs co-cultures with chondron in induced osteoarthritis (OA). Methods: ASC, from the peri-renal fat of male rat and chondron from primary newborn rat hyaline cartilage were isolated. ASCs were cultured for at least three passages in vitro...
June 2018: Advanced Pharmaceutical Bulletin
Davod Pashoutan Sarvar, Mohammad Hossein Karimi, Aliakbar Movassaghpour, Parvin Akbarzadehlaleh, Sara Aqmasheh, Hamze Timari, Karim Shamsasenjan
Purpose: Mesenchymal stem cells (MSCs) play an important role in the proliferation and differentiation of hematopoietic stem cells (HSCs) in the bone marrow via cell-to-cell contact, as well as secretion of cytokines and microvesicles (MVs). In this study, we investigated the effect of mesenchymal stem cell-derived microvesicles (MSC-MVs) on erythroid differentiation of umbilical cord blood-derived CD34+ cells. Methods: In this descriptive study, CD34+ cells were cultured with mixture of SCF (10 ng/ml) and rhEPO (5 U/ml) cytokines in complete IMDM medium as positive control group...
June 2018: Advanced Pharmaceutical Bulletin
Fereshteh Morrovati, Nahid Karimian Fathi, Jafar Soleimani Rad, Azadeh Montaseri
Purpose: In Persian traditional medicine, application of Mummy material has been advised since hundred years ago for treatment of different diseases as bone fracture, cutaneous wounds and joint inflammation. Regarding to the claim of indigenous people for application of this material in the treatment of joint inflammation, the present study was designed to evaluate whether Mummy can revoke the inflammatory responses in chondrocytes stimulated with interleukin 1-β (IL-1β). Methods: Isolated chondrocytes at the second passage were plated in 50 ml conical tubes at density of 1x106 for pellet culture or were plated in T75 culture flasks as monolayer...
June 2018: Advanced Pharmaceutical Bulletin
Elham Baghbani, Vahid Khaze, Sanam Sadreddini, Ahad Mokhtarzadeh, Behzad Mansoori, Ali Mohammadi, Vida Vatankhahan, Parisa Toosi, Behzad Baradaran
Purpose: T-cell acute lymphoblastic leukemia (T-ALL) is one of the most common malignancies associated with T-lymphocytes, accounting for 10 to 15 percent of ALL cases in children and 25 percent in adults. Innovative therapeutic approaches that overcome ineffective treatments on tumor cells may be a potential source of improvement in therapeutic approaches. Suppression of gene expression at transfusion level is one of the important strategies in gene therapy. The expression of PTPN22 and miR-181 genes in all types of hematologic malignancies increases and is likely to contribute to the survival and death of cells by affecting a variety of signaling pathways...
June 2018: Advanced Pharmaceutical Bulletin
Vnira Rakhimovna Akhmetova, Rozalia Akramovna Galimova, Nail Salavatovich Akhmadiev, Albina Midkhatovna Galimova, Ravil Akhmetzyanovich Khisamutdinov, Galiya Maratovna Nurtdinova, Eduard Feliksovich Agletdinov, Valery Alekseevich Kataev
Purpose: This research is devoted to designing the synthesis of sulfanyl-substituted 3,5-dimethylisoxazoles, which contain structural analogues of the SAM drug in the molecule. SAM (S-adenosyl-L-methionine), formed in the biosynthetic process, is used as an effective hepatoprotective drug. Complexation and hepatoprotective properties of the combinatorial series of bis(isoxazolylsulfanyl)ethane have been studied. Methods: Bis(isoxazol-4-ylmethylsulfanyl)alkanes were synthesized using the one-pot method. The structures of compounds were established by one-dimensional (1 H,13 C) and two-dimensional (COSY, HCQS, HMBC) NMR spectroscopy, mass-spectrometry and X-ray diffraction...
June 2018: Advanced Pharmaceutical Bulletin
Yadhu Krishnan, Shilpa Mukundan, Suresh Akhil, Swati Gupta, Vidya Viswanad
Purpose: The current study aims the lymphatic delivery of leflunomide loaded nanostructured lipid carriers (LNLC) for the treatment of rheumatoid arthritis, mainly focussed to enhance the lymphatic delivery via chylomicron formation, improved bioavailability and reduced systemic toxicity. Methods: Melt emulsification ultra-sonication method was used to formulate the nanostructured lipid carrier (NLC) containing leflunomide. Four batches were prepared by using various concentration of surfactants (tween 80 and poloxmer 188) and lipid mixtures (stearic acid and oleic acid)...
June 2018: Advanced Pharmaceutical Bulletin
Molood Alsadat Vakilinezhad, Shima Tanha, Hashem Montaseri, Rassoul Dinarvand, Amir Azadi, Hamid Akbari Javar
Purpose: Solid lipid nanoparticles (SLNs) have been proven to possess pharmaceutical advantages. They have the ability to deliver hydrophilic drugs through lipid membranes of the body. However, the loading of such drugs into SLNs is challenging. Hydrophilic nicotinamide, a histone deacetylase inhibitor, is used to establish SLNs with enhanced encapsulation efficiency by using statistical design. Methods: The possible effective parameters of these particles' characteristics were determined using pre-formulation studies and preliminary tests...
June 2018: Advanced Pharmaceutical Bulletin
Fataneh Narchin, Kambiz Larijani, Abdolhossein Rustaiyan, Samad Nejad Ebrahimi, Farzaneh Tafvizi
Purpose: A lot of plants are available which can produce nanoparticles used in medicine, life sciences, and the pharmaceutical industry. The present study aims to introduce safe biological and eco-friendly methods for synthesizing silver nanoparticles (AgNPs) by using Saturaja rechengri Jamzad extract, which can replace traditional chemical methods. In addition, the chemical nature and antimicrobial activities were identified and accordingly the anticancer effects of AgNPs was successfully reported on colon cancer cells (HT-29)...
June 2018: Advanced Pharmaceutical Bulletin
Smriti Ojha, Babita Kumar
Purpose: The objective of this study was to synthesize and statistically optimize dimethyl fumarate (DMF) loaded solid lipid nanoparticles (SLNs) for better management of multiple sclerosis (MS). Methods: SLNs were formulated by hot emulsion, ultrasonication method and optimized with response surface methodology (RSM). A three factor and three level box-behnken design was used to demonstrate the role of polynomial quadratic equation and contour plots in predicting the effect of independent variables on dependent responses that were particle size and % entrapment efficiency (%EE)...
June 2018: Advanced Pharmaceutical Bulletin
Seyyed Pouya Hadipour Moghaddam, Sajjad Farhat, Alireza Vatanara
Purpose: The goal of this study was to improve the solubility and dissolution behavior of Raloxifene Hydrochloride (RH) using Spray Freeze Drying (SFD) technique. Methods: For achieving this goal, series of samples containing RH with polyvinylpyrrolidone (PVP) or hydroxypropyl beta cyclodextrin (HPβCD) used as solubility enhancers were prepared and microparticles were formed via SFD. The resultant microparticles were physicochemically characterized. Morphology of the microparticles were observed using Scanning Electron Microscopy (SEM)...
June 2018: Advanced Pharmaceutical Bulletin
Behnoush Hossein-Nia, Sirous Khorram, Hassan Rezazadeh, Abdolrasol Safaiyan, Rafigheh Ghiasi, Ali Tarighat-Esfanjani
Purpose: To determine the effect of natural clinoptilolite (CLN) and nano-sized clinoptilolite (NCLN) on lipid profile, food intakes (FI) and weight changes in streptozotocin (STZ) induced diabetic rats. Methods: In this experimental study, 36 rats were randomly divided into two groups: diabetic group which was injected STZ (60 mg/kg BW), and a non-diabetic group. Three days after diabetes induction, each of these groups was randomly divided into 3 subgroups of 6 animals ((1) control, (2) 1%/food CLN, (3) 1%/food NCLN)...
June 2018: Advanced Pharmaceutical Bulletin
Ehsan Nassireslami, Morteza Ajdarzade
Purpose: Unique physiochemical properties of Fe2 O3 nanoparticles make them great agents to serve as therapeutic and diagnostic nanoparticles (NPs). In this study, we developed gold coated Fe2 O3 nanoparticles for photothermal therapy of breast cancer cells. Methods: Fe2 O3 nanoparticles was prepared via microemulsion method and their surface was modified via gold. Differential light scattering (DLS) and transmission electron microscopy (TEM) methods were applied to evaluate physicochemical properties of NPs...
June 2018: Advanced Pharmaceutical Bulletin
Mahmood Alizadeh-Sani, Hamed Hamishehkar, Arezou Khezerlou, Maryam Azizi-Lalabadi, Yaghob Azadi, Elyas Nattagh-Eshtivani, Mehdi Fasihi, Abed Ghavami, Aydin Aynehchi, Ali Ehsani
Emulsifiers are a large category of compounds considered as surface active agents or surfactants. An emulsifier acts by reducing the speed of chemical reactions, and enhancing its stability. Bioemulsifiers are known as surface active biomolecule materials, due to their unique features over chemical surfactants, such as non-toxicity, biodegradability, foaming, biocompatibility, efficiency at low concentrations, high selectivity in different pH, temperatures and salinities. Emulsifiers are found in various natural resources and are synthesized by Bacteria, Fungi and Yeast...
June 2018: Advanced Pharmaceutical Bulletin
Aura Rusu, Gabriel Hancu, Silvia Imre
To describe the chemical structure and characterize physico-chemical properties of organometallic complexes it is necessary to use a complex set of analysis methods. Thus, this review has been compiled as a relevant guide which includes the most commonly used methods of analysis in the study of silver complexes with antibacterial quinolones, compounds with promising biological potential. This selection of analysis methods puts on balance the obtained data and the accessibility of the experimental approach. The steps to follow in order to obtain reliable structural information about organometallic complexes of silver, particularly the silver complexes of antibacterial quinolones, are established and presented in the review...
June 2018: Advanced Pharmaceutical Bulletin
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