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Research and Reports in Urology

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https://www.readbyqxmd.com/read/28507979/microtubule-associated-protein-tau-is-associated-with-the-resistance-to-docetaxel-in-prostate-cancer-cell-lines
#1
Jian Yang, Yang Yu, Wei Liu, Zhi Li, Zhongqing Wei, Rongjiang Jiang
Tau, a microtubule-associated protein, has been investigated primarily in neurons. Recently, tau has been explored to be associated with increased drug resistance in various kinds of cancers. We found that the tau was expressed in prostate cancer cell lines DU145 and PC-3. We also reported that recurrent prostate cancer cells after docetaxel treatment have higher levels of microtubule-associated protein tau. In vitro, inactivation of tau by gene knockdown suppressed cell proliferation and sensitized docetaxel cytotoxicity...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28491861/enteric-coated-and-highly-standardized-cranberry-extract-reduces-antibiotic-and-nonsteroidal-anti-inflammatory-drug-use-for-urinary-tract-infections-during-radiotherapy-for-prostate-carcinoma
#2
Alberto Bonetta, Giandomenico Roviello, Daniele Generali, Laura Zanotti, Maria Rosa Cappelletti, Chiara Pacifico, Francesco Di Pierro
INTRODUCTION: Worldwide, bacterial resistance to antibiotic therapy is a major concern for the medical community. Antibiotic resistance mainly affects Gram-negative bacteria that are an important cause of lower urinary tract infections (LUTIs). Pelvic irradiation for prostate cancer is a risk factor for LUTIs. Cranberry extract is reported to reduce the incidence of LUTIs. The prophylactic role of an enteric-coated, highly standardized cranberry extract (VO370(®)) in reducing LUTI episodes, urinary discomfort, and nonsteroidal anti-inflammatory drug (NSAID) and antibiotic use during radiotherapy for prostate carcinoma was evaluated...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28459044/prostate-mri-prior-to-radical-prostatectomy-effects-on-nerve-sparing-and-pathological-margin-status
#3
Sasha C Druskin, Jen-Jane Liu, Allen Young, Zhaoyong Feng, Seyed S Dianat, Wesley W Ludwig, Bruce J Trock, Katarzyna J Macura, Christian P Pavlovich
OBJECTIVES: The aim of this study was to assess the positive surgical margin (PSM) and nerve sparing (NS) rates in patients who underwent prostate MRI (pMRI) prior to radical prostatectomy (RP) and compare them with matched, nonimaged control RP patients. METHODS: We identified 204 men who underwent preoperative pelvic MRI (pelMRI), of whom 176 (86.3%) underwent pMRIs, within 60 days of RP, and compared them (1:1) with a nonim-aged control group matched by surgeon, age, race, body mass index (BMI), prostate-specific antigen (PSA), pathological Gleason score, prostate specimen weight, and RP year...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28357204/eosinophilic-cystitis-with-recurrent-urinary-retention-case-report
#4
Hongzoo Park
Eosinophilic cystitis is a rare inflammatory disease of the bladder whose origin, pathogenesis, and treatment are unknown. Frequency, dysuria, and hematuria are frequent symptoms. Here, we report a rare occurrence of recurrent urinary retention and repetitive catheterization. A 67-year-old male presented with acute urinary retention and intermittent gross hematuria of 2 weeks duration. Urethral catheterization followed by a trial without catheter, was successful. Complete blood count showed presence of eosinophils (eosinophilia) and computed tomography of kidneys, ureter and bladder with contrast showed thickened bladder wall and small prostate...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28352615/results-of-a-randomized-prospective-double-dummy-double-blind-trial-to-compare-efficacy-and-safety-of-a-herbal-combination-containing-tropaeoli-majoris-herba-and-armoraciae-rusticanae-radix-with-co-trimoxazole-in-patients-with-acute-and-uncomplicated-cystitis
#5
Rainer Stange, Berthold Schneider, Uwe Albrecht, Valentina Mueller, Joerg Schnitker, Andreas Michalsen
OBJECTIVES: To demonstrate non-inferiority of an herbal combination (horseradish root and nasturtium herb) to an antibiotic (co-trimoxazole) in acute uncomplicated cystitis. DESIGN: Randomized, prospective, double-blind, double-dummy, multicenter, phase III clinical study, using block randomization of 4 blocks (size 2). SETTING: Twenty-six centers in Germany, from May 2011 to June 2013. PARTICIPANTS: Adult patients (median age, 38...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28280717/impact-of-preoperative-screening-for-rectal-colonization-with-fluoroquinolone-resistant-enteric-bacteria-on-the-incidence-of-sepsis-following-transrectal-ultrasound-guided-prostate-biopsy
#6
John J Farrell, Jennifer L Hicks, Stephanie E Wallace, Allen D Seftel
With the universal adoption of antibiotic prophylaxis prior to prostate biopsy, the current risk of post-biopsy infection (including sepsis) is <2%. Preoperative prophylactic antibiotic regimens can vary, and although fluoroquinolones have emerged as the standard of care, there is no universally agreed upon preoperative antibiotic regimen. Recently, an increase in the proportion of postoperative infections caused by fluoroquinolone-resistant Escherichia coli (as well as other Enterobacteriaceae) has led to the exploration of simple, practical, and cost-effective methods to minimize this postoperative infection risk...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28261572/effect-of-triptorelin-on-lower-urinary-tract-symptoms-in-australian-prostate-cancer-patients
#7
Henry H Woo, Declan G Murphy, Gerard M Testa, Jeremy P Grummet, Michael Chong, Andrew P Stork
PURPOSE: Prostate cancer is often comorbidly associated with lower urinary tract symptoms (LUTS), but few studies have assessed the effects of androgen deprivation therapy on LUTS in this patient group. PATIENTS AND METHODS: We conducted a prospective, noninterventional, multicenter, observational study to assess the effectiveness of triptorelin (11.25 mg every 12 weeks) over 48 weeks in men presenting with local stage T3/4 prostate cancer and moderate to severe LUTS (International Prostate Symptom Score [IPSS] >7) in a routine practice setting in Australia...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28203551/digital-ureteroscopes-technology-update
#8
REVIEW
Chad M Gridley, Bodo E Knudsen
The field of ureteroscopy has undergone a continual evolution since the first ureteroscopes were introduced. Over the past 10 years, we have entered into the digital era of ureteroscopy with both semirigid and flexible options becoming available. The following review looks at the benefits and drawbacks of digital flexible ureteroscopes as well as the current commercially available options.
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28176949/prophylactic-furosemide-infusion-decreasing-early-major-postoperative-renal-dysfunction-in-on-pump-adult-cardiac-surgery-a-randomized-clinical-trial
#9
Solmaz Fakhari, Fariba Mirzaei Bavil, Eissa Bilehjani, Sona Abolhasani, Moussa Mirinazhad, Bahman Naghipour
INTRODUCTION: Acute renal dysfunction is a common complication of cardiac surgery. Furosemide is used in prevention, or treatment, of acute renal dysfunction. This study was conducted to evaluate the protective effects of intra- and early postoperative furosemide infusion on preventing acute renal dysfunction in elective adult cardiac surgery. METHODS: Eighty-one patients, candidates of elective cardiac surgery, were enrolled in this study in either the furosemide (n=41) or placebo (n=40) group...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28176914/upward-migration-of-a-ureteric-stone-in-a-military-trainer-a-case-report
#10
Moayid Fallatah, Sakher Tahaineh, Rawan Abu Mughli, Seddig M Fallatah
Retrograde ureteric stone migration is an extremely rare phenomenon with only one previously reported case in the literature. We report on a case of upward spontaneous migration of a ureteric stone in a 39-year-old male military trainer in Saudi Arabia who was diagnosed with upper left ureteric stone based on non-contrast spiral computerized tomography kidney ureter bladder (CT-KUB) scan. The plan was to treat the patient conservatively with alpha blockers and oral hydration. Two weeks after treatment started, repeated CT-KUB scan revealed an upward migration of the stone to the left renal calyx...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28116283/using-central-venous-catheter-for-suprapubic-catheterization-in-cardiac-surgery
#11
Eissa Bilehjani, Solmaz Fakhari
Suprapubic catheterization is an alternative method for urinary drainage that is used when transurethral catheterization fails. Traditionally, inserted large-bore suprapubic catheters may cause fatal complications. During the past decade, we used a small central venous catheter (CVC) suprapubicly in 16 male patients for the purpose of urinary drainage, when transurethral catheterization failed. The procedure is performed in no more than 10 minutes. Success rate was 100% and this approach did not lead to any complications...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/27981044/evaluation-of-biochemical-recurrence-in-patients-with-high-risk-prostate-cancer-treated-with-radical-prostatectomy-and-radiotherapy-plus-androgen-deprivation-therapy
#12
Yutaka Yamamoto, Keisuke Kiba, Motokiyo Yoshikawa, Akihide Hirayama, Seiji Kunikata, Hirotsugu Uemura
OBJECTIVE: The aim of this study was to evaluate the biochemical recurrence (BCR) in patients with high-risk prostate cancer (PCa) treated with radical prostatectomy (RP) or radiotherapy (RT) plus androgen deprivation therapy (ADT). METHODS: Subjects were patients with National Comprehensive Cancer Network-defined high-risk PCa treated with either RP or RT plus ADT. We calculated BCR-free survival in patients with those treatments and evaluated risk factor against BCR...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27942507/impact-of-enzalutamide-on-patient-related-outcomes-in-metastatic-castration-resistant-prostate-cancer-current-perspectives
#13
REVIEW
Jia Luo, Julie N Graff
Prostate cancer claims the lives of more than 25,000 men in the United States yearly, most from metastatic disease. In the past decade, several new medications have been approved for the treatment of metastatic prostate cancer including the antiandrogen enzalutamide. In addition, there has been mounting interest in evaluating health-related quality of life (QoL) in patients with cancer including new more detailed recommendations released by the Prostate Cancer Working Group 3 on how to evaluate patient-related outcomes in clinical trials...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27921028/two-year-results-after-convective-radiofrequency-water-vapor-thermal-therapy-of-symptomatic-benign-prostatic-hyperplasia
#14
Christopher M Dixon, Edwin Rijo Cedano, Dalibor Pacik, Vítězslav Vit, Gabriel Varga, Lennart Wagrell, Thayne R Larson, Lance A Mynderse
OBJECTIVE: The objective of this study was to assess the effectiveness and safety of convective radiofrequency (RF) water vapor thermal therapy in men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH); a pilot study design with 2-year follow-up evaluations. PATIENTS AND METHODS: Men aged ≥45 years with an International Prostate Symptom Score ≥13, a maximum urinary flow rate (Qmax) ≤15 mL/s, and prostate volume 20-120 cc were enrolled in a prospective, open-label pilot study using convective RF water vapor energy with the Rezūm System...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27822463/association-of-prostate-volume-with-incidence-and-aggressiveness-of-prostate-cancer
#15
Shadi Al-Khalil, Christine Ibilibor, James Thomas Cammack, Werner de Riese
OBJECTIVE: The aim of this study was to investigate the possible correlation between prostate volume and aggressiveness and incidence of prostate cancer (PCa). PATIENTS AND METHODS: A chart review of a cohort of 448 consecutive prostate biopsy-naive men was performed. These men underwent at least a 12-core biopsy at our institution due to increased prostate-specific antigen serum levels (>4 ng/mL) and/or suspicious findings on digital rectal examination during the period between 2008 and 2013...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27822462/sacral-neuromodulation-in-overactive-bladder-a-review-and-current-perspectives
#16
REVIEW
Troy Sukhu, Michael J Kennelly, Raj Kurpad
Overactive bladder (OAB) symptoms of urgency, frequency, and urge incontinence currently affect a substantial portion of the population, especially as age increases. Sacral neuromodulation has become a popular option for refractory OAB symptoms over the past 2 decades. Studies have demonstrated that it is an effective treatment for OAB and urge incontinence as indicated by decreased number of voids, increased bladder capacity, and fewer leakage events. In addition, the effects have proved to be durable to multiple years following implantation...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27822461/retroperitoneal-fibrosis-retrospective-descriptive-study-on-clinical-features-and-management
#17
Ann-Sophie Laroche, Robert Z Bell, Sarah Bezzaoucha, Eva Földes, Caroline Lamarche, Michel Vallée
INTRODUCTION: Retroperitoneal fibrosis (RPF) is a rare condition characterized by the presence of inflammatory and fibrous retroperitoneal tissue that often encases the ureters or abdominal organs. This study describes the clinical characteristics, diagnostic methods, and treatments and their effects on renal function. METHODS: We conducted a retrospective analysis of patients diagnosed with RPF at Maisonneuve-Rosemont Hospital. RESULTS: We identified 17 patients with RPF between 1998 and 2013...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27800470/holmium-laser-enucleation-of-the-prostate-patient-selection-and-perspectives
#18
REVIEW
Tracy Marien, Mustafa Kadihasanoglu, Nicole L Miller
BACKGROUND: Multiple endoscopic surgical options exist to treat benign prostatic hyperplasia (BPH), including holmium laser enucleation of the prostate (HoLEP). HoLEP alleviates obstructive prostatic tissue via enucleation, both bluntly with a resectoscope and by cutting tissue with the holmium laser, and removal of adenoma via morcellation. This article reviews patient selection for HoLEP in order to optimize outcomes, costs, and patient satisfaction. METHODS: A literature review of all studies on HoLEP was conducted...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27730097/development-of-a-ct-guided-standard-approach-for-tined-lead-implantation-at-the-sacral-nerve-root-s3-in-minipigs-for-chronic-neuromodulation
#19
Elena Esra Foditsch, Reinhold Zimmermann
PURPOSE: The aim of this study was to develop a controlled approach for sacral neuromodulation (SNM) to improve both nerve targeting and tined lead placement, for which a new computed tomography (CT)-guided implantation technique was analyzed in minipigs. MATERIALS AND METHODS: This study included five female, adult Göttingen minipigs. In deep sedoanalgesia, the minipigs were placed in an extended prone position. Commercially available SNM materials were used (needle, introduction sheath, and quadripolar tined lead electrode)...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27695691/xanthogranulomatous-prostatitis-with-prostato-rectal-fistula-a-case-report-and-review-of-the-literature
#20
Liyong Xing, Zhifei Liu, Gang Deng, Huan Wang, Yanfeng Zhu, Peng Shi, Bingyue Huo, Yindong Li
PURPOSE: Xanthogranulomatous prostatitis (XP) is a rare form of nonspecific granulomatous prostatitis that can clinically mimic high-grade prostatic carcinoma. It is difficult to diagnose it definitely in clinical settings. METHODS: We report a case of XP with prostate-rectal fistula and review the relevant literatures. RESULT: A 75-year-old man presented with rectal bleeding when he urinated. A locally advanced carcinoma of prostate was suspected initially following the physical, imaging, and hematologic examinations...
2016: Research and Reports in Urology
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