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Research and Reports in Urology

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https://www.readbyqxmd.com/read/29134181/pregnancy-and-live-birth-after-follicle-stimulating-hormone-treatment-for-an-infertile-couple-including-a-male-affected-by-sertoli-cell-only-syndrome
#1
Gianni Paulis, Luca Paulis, Gennaro Romano, Carmen Concas, Marika Di Sarno, Renata Pagano, Antonio Di Filippo, Maria Luisa Di Petrillo
In males with nonobstructive azoospermia, one of the main histopathologic patterns of the testis is Sertoli cell-only syndrome (SCOS), in which no germ cells are present and only Sertoli cells are contained in the seminiferous tubules. There is not any formal treatment for this pathological condition. However, several studies reported the possibility to perform testicular sperm extraction in patients with SCOS, although, according to some authors, sperm retrieval is possible only in the presence of focal spermatogenesis...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/29034222/risk-factor-assessment-in-high-risk-bacillus-calmette-gu%C3%A3-rin-treated-non-muscle-invasive-bladder-cancer
#2
Serge Holz, Simone Albisinni, Jacques Gilsoul, Michel Pirson, Véronique Duthie, Thierry Quackels, Marc Vanden Bossche, Thierry Roumeguère
OBJECTIVE: To assess the risk factors associated with recurrence, progression and survival in high-risk non-muscle-invasive bladder cancer (NMIBC) patients treated with bacillus Calmette-Guérin (BCG) and validate the European Organization for Research and Treatment of Cancer (EORTC) and Spanish Urological Club for Oncological Treatment (CUETO) scores. PATIENTS AND METHODS: We retrospectively analyzed all BCG-treated NMIBC patients from 1998 to 2012. Multiple variables were tested as risk factors for recurrence-free survival and progression-free survival (PFS)...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/29034221/atypical-small-acinar-proliferation-and-two-or-more-cores-of-high-grade-intraepithelial-neoplasia-on-a-previous-prostate-biopsy-are-significant-predictors-of-cancer-during-a-transperineal-template-guided-saturation-biopsy-aimed-at-sampling-one-core-for-each
#3
Yasushi Nakai, Nobumichi Tanaka, Makito Miyake, Shunta Hori, Yoshihiro Tatsumi, Yosuke Morizawa, Tomomi Fujii, Noboru Konishi, Kiyohide Fujimoto
OBJECTIVE: The objective of this study was to evaluate whether high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP) predict prostate cancer (PCa) during repeat transperineal template saturation biopsy with a high number of cores per prostate volume in patients with persistent clinical suspicion of PCa who underwent at least one previous negative transrectal ultrasound (TRUS)-guided biopsy. METHODS: We retrospectively evaluated 135 consecutive patients with persistent clinical suspicion of PCa, despite a set of negative TRUS-guided biopsies and increasing prostate-specific antigen levels; abnormal findings on digital rectal examination, TRUS, or magnetic resonance imaging; previous biopsy showing HGPIN; and previous biopsy showing atypical glands...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28979891/at1-expression-in-human-urethral-stricture-tissue
#4
Safendra Siregar, Aga Parardya, Jupiter Sibarani, Tjahjodjati Romdan, Kuncoro Adi, Bethy S Hernowo, Anglita Yantisetiasti
BACKGROUND: Urethral stricture has a high recurrence rate. There is a common doctrine stating that "once a stricture, always a stricture". This fibrotic disease pathophysiology, pathologically characterized by excessive production, deposition and contraction of extracellular matrix is unknown. Angiotensin II type 1 (AT1) receptor primarily induces angiogenesis, cellular proliferation and inflammatory responses. AT1 receptors are also expressed in the fibroblasts of hypertrophic scars, whereas angiotensin II (AngII) regulates DNA synthesis in hypertrophic scar fibroblasts through a negative cross talk between AT1 and angiotensin II type 2 (AT2) receptors, which might contribute to the formation and maturation of human hypertrophic scars...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28920056/management-of-refractory-ischemic-priapism-current-perspectives
#5
REVIEW
Marco Capece, Arianna Gillo, Andrea Cocci, Giulio Garaffa, Massimiliano Timpano, Marco Falcone
OBJECTIVES: The aim of the present manuscript is to review the current literature on priapism, focusing on the state-of-the-art knowledge of both the diagnosis and the treatment of the refractory ischemic priapism (IP). METHODS: Pubmed and EMBASE search engines were used to search for words "priapism", "refractory priapism", "penile prosthesis", "diagnosis priapism", "priapism treatment", "penile fibrosis", "priapism therapy". All the studies were carefully examined by the authors and then included in the review...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28920055/distinguishing-testicular-torsion-from-torsion-of-the-appendix-testis-by-clinical-features-and-signs-in-patients-with-acute-scrotum
#6
Naoyuki Fujita, Mitsuhiro Tambo, Takatsugu Okegawa, Eiji Higashihara, Kikuo Nutahara
PURPOSE: Many physicians encounter confusion and difficulty in distinguishing testicular torsion (TT) from torsion of the appendix testis (TAT) in patients with acute scrotum because of the overlapping signs and symptoms. The objective of our study was to evaluate the clinical features and signs that can help distinguish TT from TAT. PATIENTS AND METHODS: We performed a retrospective study of patients with surgically confirmed TT and TAT at our institute from January 1990 to December 2013...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28861405/procedural-techniques-and-multicenter-postmarket-experience-using-minimally-invasive-convective-radiofrequency-thermal-therapy-with-rez%C3%A5-m-system-for-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia
#7
Micheal F Darson, Erik E Alexander, Zvi J Schiffman, Michael Lewitton, Robert A Light, Mark A Sutton, Carlos Delgado-Rodriguez, Ricardo R Gonzalez
OBJECTIVE: This report evaluates clinical experience with the Rezūm system after US Food and Drug Administration clearance in consecutive cases accrued by multiple community urologists for the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Treatment techniques for transurethral convective radiofrequency water-vapor thermal therapy and outcomes with up to 12 months' follow-up are presented. MATERIALS AND METHODS: A total of 131 patients with moderate-severe LUTS were included in a retrospective analysis of BPH procedures with the Rezūm system...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28861404/effectiveness-of-percutaneous-tibial-nerve-stimulation-in-the-treatment-of-overactive-bladder-syndrome
#8
REVIEW
Liesbeth L de Wall, John Pfa Heesakkers
Overactive bladder syndrome (OAB) is a common condition affecting adults and children worldwide, resulting in a substantial economic and psychological burden. Percutaneous tibial nerve stimulation (PTNS) is derived from acupuncture used in Chinese traditional medicine and was first described in the early 1980s. It is a neuromodulation technique used to modulate bladder function and facilitate storage. Being a minimally invasive, easily applicable, but time-consuming treatment, future developments with implantable devices might be the solution for the logistical problems and economic burden associated with PTNS on the long term...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28861403/acotiamide-hydrochloride-hydrate-added-to-combination-treatment-with-an-%C3%AE-blocker-and-a-cholinergic-drug-improved-the-qol-of-women-with-acute-urinary-retention-case-series
#9
Koichi Sugimoto, Takahiro Akiyama, Nobutaka Shimizu, Naoki Matsumura, Mamoru Hashimoto, Takafumi Minami, Kazuhiro Nose, Masahiro Nozawa, Kazuhiro Yoshimura, Hirotsugu Uemura
Acute urinary retention is the most common urological emergency. To resolve this emergency, urethral catheterization is performed. If the procedure fails and permanent transurethral catheterization is required, the patient's quality of life is significantly affected. Therefore, catheter-free treatment is the ideal goal of therapy for patients with acute urinary retention. Especially, for women, placement of a catheter poses a cosmetic problem. Therefore, the aim of this study was to treat female patients who had already received urapidil/distigmine bromide with acotiamide...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28791261/rationale-of-combination-therapy-with-antioxidants-in-medical-management-of-peyronie-s-disease-results-of-clinical-application
#10
Gianni Paulis, Andrea Paulis, Gennaro Romano, Davide Barletta, Andrea Fabiani
Peyronie's disease (PD) is a connective tissue disorder involving the tunica albuginea of the corpora cavernosa of the penis. We have published several studies describing a "combined therapy" for PD patients, but the present study aims to clearly demonstrate how the association between various antioxidants in PD treatment can significantly increase the likelihood of therapeutic success. We used the following substances: silymarin, ginkgo biloba, vitamin E, bilberry, topical diclofenac sodium, and pentoxifylline (PTX)...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28761863/management-of-urinary-tract-infections-in-patients-with-neurogenic-bladder-challenges-and-solutions
#11
REVIEW
Jürgen Pannek, Jens Wöllner
INTRODUCTION: Urinary tract infections (UTIs) are one of the most common morbidities in persons with neurogenic lower urinary tract dysfunction (NLUTD). They are associated with a significant morbidity and mortality, and they affect the quality of life of the affected patients. Diagnosis and treatment of UTI in this group of patients are challenging. In this review, the current strategies regarding diagnosis, treatment, and prevention are summarized. DIAGNOSTICS: it is important to correctly diagnose a UTI, as treatment of bacteriuria should strictly be avoided...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28721348/systematic-genetic-screening-in-a-prospective-group-of-danish-patients-with-pheochromocytoma
#12
Morten Steen Svarer Hansen, Niels Jacobsen, Anja Lisbeth Frederiksen, Lars Lund, Marianne Skovsager Andersen, Dorte Glintborg
Recent guidelines recommend consideration of genetic screening in all newly diagnosed patients with pheochromocytoma. Patients diagnosed with pheochromocytoma in the Region of Southern Denmark during 2006-2013 without previously recognized monogenetic etiology were offered genetic screening for mutations in the VHL, RET, SDHB, SDHC, and SDHD genes. A total of 41 patients were included, and genetic data were available in 35. In four of the 35 patients, a pathogenic variant was identified prior to the diagnosis of pheochromocytoma (von Hippel-Lindau disease, n=2; neurofibromatosis type 1, n=2)...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28685130/surgical-intervention-for-renal-cell-carcinoma-with-inferior-vena-cava-extension-combined-with-laparoscopic-procedure
#13
Toshio Kamimura, Kazutaka Kida, Masashi Takeda, Shunsuke Sato, Masato Fujii, Masahiro Inoue, Hiromasa Tsukino, Shoichiro Mukai, Atsushi Nanashima, Kunihide Nakamura, Toshiyuki Kamoto
Clear cell renal cell carcinoma (ccRCC) shows extreme hypervascularity, which may cause significant bleeding during surgery. For this reason, control of arterial blood supply is an important factor in the choice of operative procedure and in avoiding perioperative complications. This case series reports the successful dissection of renal artery in the preliminary stage of laparoscopic procedure in three ccRCC patients with inferior vena cava (IVC) extension. Patient 1 had right renal cell carcinoma (RCC) with level I tumor thrombus through two renal veins, and the renal artery was successfully dissected by retroperitonealscopic approach...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28685129/does-intraperitoneal-injection-of-propofol-prior-to-detorsion-improve-testes-weight-and-histopathological-findings-in-a-rat-model
#14
Shahriar Amirhassani, Sasan Mehrabi, Seyed Mohammad Hosseinipanah, Abdolmajid Iloon Kashkouli, Saadat Torabian, Mohammad Kazem Moslemi
OBJECTIVES: To determine the long-term preventive effects of intraperitoneal propofol on testicular ischemia-reperfusion injury in a rat model. MATERIALS AND METHODS: Forty adult male albino Wistar rats were divided randomly into the following four groups according to the planned treatment (n=10 per group): group I, control; group II, sham-operated; group III, torsion/detorsion (T/D); and group IV, T/D plus propofol. Testicular ischemia was achieved by twisting the left testis 720° clockwise (ie, applying torsion) for 1 h...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28652996/mitochondrial-stress-and-activation-of-pi3k-and-akt-survival-pathway-in-bladder-ischemia
#15
Jing-Hua Yang, Mike B Siroky, Subbarao V Yalla, Kazem M Azadzoi
PURPOSE: Detrusor overactivity contributes to bothersome constellation of lower urinary tract symptoms (LUTS) in men and women as they age. However, the underlying mechanisms of non-obstructive detrusor overactivity and LUTS remain largely unknown. Growing evidence suggests that ischemia may be an independent factor in the development of non-obstructive bladder dysfunction. Our goal was to determine the effects of ischemia on detrusor function and voiding behavior and define redox-mediated cellular stress and cell survival signaling in the ischemic bladder...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28546955/biofabrication-and-biomaterials-for-urinary-tract-reconstruction
#16
REVIEW
Moustafa M Elsawy, Achala de Mel
Reconstructive urologists are constantly facing diverse and complex pathologies that require structural and functional restoration of urinary organs. There is always a demand for a biocompatible material to repair or substitute the urinary tract instead of using patient's autologous tissues with its associated morbidity. Biomimetic approaches are tissue-engineering tactics aiming to tailor the material physical and biological properties to behave physiologically similar to the urinary system. This review highlights the different strategies to mimic urinary tissues including modifications in structure, surface chemistry, and cellular response of a range of biological and synthetic materials...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28507979/microtubule-associated-protein-tau-is-associated-with-the-resistance-to-docetaxel-in-prostate-cancer-cell-lines
#17
Jian Yang, Yang Yu, Wei Liu, Zhi Li, Zhongqing Wei, Rongjiang Jiang
Tau, a microtubule-associated protein, has been investigated primarily in neurons. Recently, tau has been explored to be associated with increased drug resistance in various kinds of cancers. We found that the tau was expressed in prostate cancer cell lines DU145 and PC-3. We also reported that recurrent prostate cancer cells after docetaxel treatment have higher levels of microtubule-associated protein tau. In vitro, inactivation of tau by gene knockdown suppressed cell proliferation and sensitized docetaxel cytotoxicity...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28491861/enteric-coated-and-highly-standardized-cranberry-extract-reduces-antibiotic-and-nonsteroidal-anti-inflammatory-drug-use-for-urinary-tract-infections-during-radiotherapy-for-prostate-carcinoma
#18
Alberto Bonetta, Giandomenico Roviello, Daniele Generali, Laura Zanotti, Maria Rosa Cappelletti, Chiara Pacifico, Francesco Di Pierro
INTRODUCTION: Worldwide, bacterial resistance to antibiotic therapy is a major concern for the medical community. Antibiotic resistance mainly affects Gram-negative bacteria that are an important cause of lower urinary tract infections (LUTIs). Pelvic irradiation for prostate cancer is a risk factor for LUTIs. Cranberry extract is reported to reduce the incidence of LUTIs. The prophylactic role of an enteric-coated, highly standardized cranberry extract (VO370(®)) in reducing LUTI episodes, urinary discomfort, and nonsteroidal anti-inflammatory drug (NSAID) and antibiotic use during radiotherapy for prostate carcinoma was evaluated...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28459044/prostate-mri-prior-to-radical-prostatectomy-effects-on-nerve-sparing-and-pathological-margin-status
#19
Sasha C Druskin, Jen-Jane Liu, Allen Young, Zhaoyong Feng, Seyed S Dianat, Wesley W Ludwig, Bruce J Trock, Katarzyna J Macura, Christian P Pavlovich
OBJECTIVES: The aim of this study was to assess the positive surgical margin (PSM) and nerve sparing (NS) rates in patients who underwent prostate MRI (pMRI) prior to radical prostatectomy (RP) and compare them with matched, nonimaged control RP patients. METHODS: We identified 204 men who underwent preoperative pelvic MRI (pelMRI), of whom 176 (86.3%) underwent pMRIs, within 60 days of RP, and compared them (1:1) with a nonim-aged control group matched by surgeon, age, race, body mass index (BMI), prostate-specific antigen (PSA), pathological Gleason score, prostate specimen weight, and RP year...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28357204/eosinophilic-cystitis-with-recurrent-urinary-retention-case-report
#20
Hongzoo Park
Eosinophilic cystitis is a rare inflammatory disease of the bladder whose origin, pathogenesis, and treatment are unknown. Frequency, dysuria, and hematuria are frequent symptoms. Here, we report a rare occurrence of recurrent urinary retention and repetitive catheterization. A 67-year-old male presented with acute urinary retention and intermittent gross hematuria of 2 weeks duration. Urethral catheterization followed by a trial without catheter, was successful. Complete blood count showed presence of eosinophils (eosinophilia) and computed tomography of kidneys, ureter and bladder with contrast showed thickened bladder wall and small prostate...
2017: Research and Reports in Urology
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