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Research and Reports in Urology

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https://www.readbyqxmd.com/read/29497605/enzalutamide-and-blocking-androgen-receptor-in-advanced-prostate-cancer-lessons-learnt-from-the-history-of-drug-development-of-antiandrogens
#1
REVIEW
Yusuke Ito, Marianne D Sadar
Enzalutamide is a nonsteroidal antiandrogen for the treatment of metastatic castration-resistant prostate cancer (mCRPC) both before and after chemotherapy. Enzalutamide is more effective than its predecessor bicalutamide, which was analyzed in head-to-head studies of patients with CRPC. This family of nonsteroidal antiandrogens is now comprised of four drugs approved by the US Food and Drug Administration with two investigational drugs in clinical trials. Antiandrogens have been employed clinically for more than five decades to provide a rich resource of information...
2018: Research and Reports in Urology
https://www.readbyqxmd.com/read/29492398/prostatic-artery-embolization-versus-transurethral-resection-of-the-prostate-in-the-treatment-of-benign-prostatic-hyperplasia-protocol-for-a-non-inferiority-clinical-trial
#2
Saturnino Napal Lecumberri, Iñigo Insausti Gorbea, Ana Sáez de Ocáriz García, Saioa Solchaga Álvarez, José Luis Cebrián Lostal, Raquel Monreal Beortegui, Pedro José Giral Villalta, Fermín Urtasun Grijalba
Background: Benign prostatic hyperplasia (BPH) is a prevalent disease associated with lower urinary tract symptoms (LUTS). The standard of care for moderate-to-severe LUTS unresponsive to pharmacological treatment is the transurethral resection of the prostate (TURP). However, this intervention is not exempt from complications. Prostatic artery embolization (PAE) has been described as a new, effective and safe procedure for the treatment of LUTS secondary to BPH. To date, only one clinical trial has been published on the use of PAE for LUTS, but the study was methodologically flawed in terms of safety monitoring...
2018: Research and Reports in Urology
https://www.readbyqxmd.com/read/29417045/urothelial-carcinoma-the-evolving-landscape-of-immunotherapy-for-patients-with-advanced-disease
#3
REVIEW
Brian Dietrich, Sandy Srinivas
Urothelial carcinoma is the sixth most common malignancy in the US. While most patients present with non-muscle-invasive disease, many will develop recurrent disease including some progressing to muscle invasive metastatic cancer. Treatment outcomes have remained poor and stagnant for those with more advanced illness, with typical 5-year survival rates in the range of ≤15%. While first-line, platinum-based chemotherapy remains the current standard for those eligible, the recent incorporation of checkpoint inhibitors into the management of advanced bladder cancer has resulted in an expansion of treatment options for a difficult-to-treat disease...
2018: Research and Reports in Urology
https://www.readbyqxmd.com/read/29392121/incidental-prostate-cancer-a-10-year-review-of-a-tertiary-center-tehran-iran
#4
Amir-Reza Abedi, Morteza Fallah-Karkan, Farzad Allameh, Arash Ranjbar, Afshin Shadmehr
Objective: Incidental prostate cancer (IPCa) is defined as a symptom-free cancer unexpectedly discovered upon microscopic examination of resected tissue. The aim of this study was to report the correlation between some specific clinical criteria in patients incidentally diagnosed with prostate cancer (PCa) during transurethral resection of the prostate (TURP) or open prostatectomy (OP) after clinically suspected benign prostatic hyperplasia. Patients and methods: This was a cross-sectional, retrospective study...
2018: Research and Reports in Urology
https://www.readbyqxmd.com/read/29264358/degarelix-treatment-is-compatible-with-diabetes-and-antithrombotic-therapy-in-patients-with-prostate-cancer
#5
Suguru Tokiwa, Hiroaki Shimmura, Shuhei Nomura, Ryota Watanabe, Minoru Kurita, Naoto Yoshida, Kaori Yamashita, Yoshitaka Nishikawa, Alexander Kouzmenko, Shigeaki Kato
Introduction: Therapeutically induced androgen deficiency (AD) is a standard treatment for patients with prostate cancer, but it is often associated with various adverse effects (AEs) that may lead to discontinuation. Some AEs may depend on the patient's health condition, while others may be due to complications of the drug delivery method. Degarelix is a gonadotropin-releasing hormone (GnRH) antagonist widely used for the treatment of androgen-dependent prostate cancer. This study aimed to ascertain the following: 1) the compatibility of degarelix treatment with diabetes and 2) any specific causal associations of degarelix injections with increased blood clotting and antithrombotic therapy requirements...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/29238702/clinical-usefulness-of-urine-cytology-in-the-detection-of-bladder-tumors-in-patients-with-neurogenic-lower-urinary-tract-dysfunction
#6
Jürgen Pannek, Franziska Rademacher, Jens Wöllner
Introduction: Screening for bladder cancer in patients with neurogenic lower urinary tract dysfunction is a challenge. Cystoscopy alone is not sufficient to detect bladder tumors in this patient group. We investigated the usefulness of combined cystoscopy and urine cytology. Materials and methods: By a systematic chart review, we identified all patients with neurogenic lower urinary tract dysfunction who underwent combined cystoscopy and urine cytology testing. In patients with suspicious findings either in cytology or cystoscopy, transurethral resection was performed...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/29184855/dealing-with-complex-overactive-bladder-syndrome-patient-profiles-with-focus-on-fesoterodine-in-or-out-of-the-eau-guidelines
#7
REVIEW
John Heesakkers, Montserrat Espuña Pons, Philip Toozs Hobson, Emmanuel Chartier-Kastler
Overactive bladder (OAB) syndrome is a common, complex, and challenging condition. To assist the management of these patients, the European Association of Urology (EAU) updates its guidelines annually. This review reports the presentations from the symposium titled "Dealing with complex OAB patient profiles: in or out of the EAU guidelines?" held at the 32nd EAU Annual Congress in March 2017 in London. The symposium focused on three groups of OAB patients: women who may also suffer pelvic organ prolapse, stress urinary incontinence, the genitourinary syndrome of menopause (GSM); patients at risk of cognitive impairment; and elderly patients...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/29134181/pregnancy-and-live-birth-after-follicle-stimulating-hormone-treatment-for-an-infertile-couple-including-a-male-affected-by-sertoli-cell-only-syndrome
#8
Gianni Paulis, Luca Paulis, Gennaro Romano, Carmen Concas, Marika Di Sarno, Renata Pagano, Antonio Di Filippo, Maria Luisa Di Petrillo
In males with nonobstructive azoospermia, one of the main histopathologic patterns of the testis is Sertoli cell-only syndrome (SCOS), in which no germ cells are present and only Sertoli cells are contained in the seminiferous tubules. There is not any formal treatment for this pathological condition. However, several studies reported the possibility to perform testicular sperm extraction in patients with SCOS, although, according to some authors, sperm retrieval is possible only in the presence of focal spermatogenesis...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/29034222/risk-factor-assessment-in-high-risk-bacillus-calmette-gu%C3%A3-rin-treated-non-muscle-invasive-bladder-cancer
#9
Serge Holz, Simone Albisinni, Jacques Gilsoul, Michel Pirson, Véronique Duthie, Thierry Quackels, Marc Vanden Bossche, Thierry Roumeguère
OBJECTIVE: To assess the risk factors associated with recurrence, progression and survival in high-risk non-muscle-invasive bladder cancer (NMIBC) patients treated with bacillus Calmette-Guérin (BCG) and validate the European Organization for Research and Treatment of Cancer (EORTC) and Spanish Urological Club for Oncological Treatment (CUETO) scores. PATIENTS AND METHODS: We retrospectively analyzed all BCG-treated NMIBC patients from 1998 to 2012. Multiple variables were tested as risk factors for recurrence-free survival and progression-free survival (PFS)...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/29034221/atypical-small-acinar-proliferation-and-two-or-more-cores-of-high-grade-intraepithelial-neoplasia-on-a-previous-prostate-biopsy-are-significant-predictors-of-cancer-during-a-transperineal-template-guided-saturation-biopsy-aimed-at-sampling-one-core-for-each
#10
Yasushi Nakai, Nobumichi Tanaka, Makito Miyake, Shunta Hori, Yoshihiro Tatsumi, Yosuke Morizawa, Tomomi Fujii, Noboru Konishi, Kiyohide Fujimoto
OBJECTIVE: The objective of this study was to evaluate whether high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP) predict prostate cancer (PCa) during repeat transperineal template saturation biopsy with a high number of cores per prostate volume in patients with persistent clinical suspicion of PCa who underwent at least one previous negative transrectal ultrasound (TRUS)-guided biopsy. METHODS: We retrospectively evaluated 135 consecutive patients with persistent clinical suspicion of PCa, despite a set of negative TRUS-guided biopsies and increasing prostate-specific antigen levels; abnormal findings on digital rectal examination, TRUS, or magnetic resonance imaging; previous biopsy showing HGPIN; and previous biopsy showing atypical glands...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28979891/at1-expression-in-human-urethral-stricture-tissue
#11
Safendra Siregar, Aga Parardya, Jupiter Sibarani, Tjahjodjati Romdan, Kuncoro Adi, Bethy S Hernowo, Anglita Yantisetiasti
BACKGROUND: Urethral stricture has a high recurrence rate. There is a common doctrine stating that "once a stricture, always a stricture". This fibrotic disease pathophysiology, pathologically characterized by excessive production, deposition and contraction of extracellular matrix is unknown. Angiotensin II type 1 (AT1) receptor primarily induces angiogenesis, cellular proliferation and inflammatory responses. AT1 receptors are also expressed in the fibroblasts of hypertrophic scars, whereas angiotensin II (AngII) regulates DNA synthesis in hypertrophic scar fibroblasts through a negative cross talk between AT1 and angiotensin II type 2 (AT2) receptors, which might contribute to the formation and maturation of human hypertrophic scars...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28920056/management-of-refractory-ischemic-priapism-current-perspectives
#12
REVIEW
Marco Capece, Arianna Gillo, Andrea Cocci, Giulio Garaffa, Massimiliano Timpano, Marco Falcone
OBJECTIVES: The aim of the present manuscript is to review the current literature on priapism, focusing on the state-of-the-art knowledge of both the diagnosis and the treatment of the refractory ischemic priapism (IP). METHODS: Pubmed and EMBASE search engines were used to search for words "priapism", "refractory priapism", "penile prosthesis", "diagnosis priapism", "priapism treatment", "penile fibrosis", "priapism therapy"...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28920055/distinguishing-testicular-torsion-from-torsion-of-the-appendix-testis-by-clinical-features-and-signs-in-patients-with-acute-scrotum
#13
Naoyuki Fujita, Mitsuhiro Tambo, Takatsugu Okegawa, Eiji Higashihara, Kikuo Nutahara
PURPOSE: Many physicians encounter confusion and difficulty in distinguishing testicular torsion (TT) from torsion of the appendix testis (TAT) in patients with acute scrotum because of the overlapping signs and symptoms. The objective of our study was to evaluate the clinical features and signs that can help distinguish TT from TAT. PATIENTS AND METHODS: We performed a retrospective study of patients with surgically confirmed TT and TAT at our institute from January 1990 to December 2013...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28861405/procedural-techniques-and-multicenter-postmarket-experience-using-minimally-invasive-convective-radiofrequency-thermal-therapy-with-rez%C3%A5-m-system-for-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia
#14
Micheal F Darson, Erik E Alexander, Zvi J Schiffman, Michael Lewitton, Robert A Light, Mark A Sutton, Carlos Delgado-Rodriguez, Ricardo R Gonzalez
OBJECTIVE: This report evaluates clinical experience with the Rezūm system after US Food and Drug Administration clearance in consecutive cases accrued by multiple community urologists for the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Treatment techniques for transurethral convective radiofrequency water-vapor thermal therapy and outcomes with up to 12 months' follow-up are presented. MATERIALS AND METHODS: A total of 131 patients with moderate-severe LUTS were included in a retrospective analysis of BPH procedures with the Rezūm system...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28861404/effectiveness-of-percutaneous-tibial-nerve-stimulation-in-the-treatment-of-overactive-bladder-syndrome
#15
REVIEW
Liesbeth L de Wall, John Pfa Heesakkers
Overactive bladder syndrome (OAB) is a common condition affecting adults and children worldwide, resulting in a substantial economic and psychological burden. Percutaneous tibial nerve stimulation (PTNS) is derived from acupuncture used in Chinese traditional medicine and was first described in the early 1980s. It is a neuromodulation technique used to modulate bladder function and facilitate storage. Being a minimally invasive, easily applicable, but time-consuming treatment, future developments with implantable devices might be the solution for the logistical problems and economic burden associated with PTNS on the long term...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28861403/acotiamide-hydrochloride-hydrate-added-to-combination-treatment-with-an-%C3%AE-blocker-and-a-cholinergic-drug-improved-the-qol-of-women-with-acute-urinary-retention-case-series
#16
Koichi Sugimoto, Takahiro Akiyama, Nobutaka Shimizu, Naoki Matsumura, Mamoru Hashimoto, Takafumi Minami, Kazuhiro Nose, Masahiro Nozawa, Kazuhiro Yoshimura, Hirotsugu Uemura
Acute urinary retention is the most common urological emergency. To resolve this emergency, urethral catheterization is performed. If the procedure fails and permanent transurethral catheterization is required, the patient's quality of life is significantly affected. Therefore, catheter-free treatment is the ideal goal of therapy for patients with acute urinary retention. Especially, for women, placement of a catheter poses a cosmetic problem. Therefore, the aim of this study was to treat female patients who had already received urapidil/distigmine bromide with acotiamide...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28791261/rationale-of-combination-therapy-with-antioxidants-in-medical-management-of-peyronie-s-disease-results-of-clinical-application
#17
Gianni Paulis, Andrea Paulis, Gennaro Romano, Davide Barletta, Andrea Fabiani
Peyronie's disease (PD) is a connective tissue disorder involving the tunica albuginea of the corpora cavernosa of the penis. We have published several studies describing a "combined therapy" for PD patients, but the present study aims to clearly demonstrate how the association between various antioxidants in PD treatment can significantly increase the likelihood of therapeutic success. We used the following substances: silymarin, ginkgo biloba , vitamin E, bilberry, topical diclofenac sodium, and pentoxifylline (PTX)...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28761863/management-of-urinary-tract-infections-in-patients-with-neurogenic-bladder-challenges-and-solutions
#18
REVIEW
Jürgen Pannek, Jens Wöllner
INTRODUCTION: Urinary tract infections (UTIs) are one of the most common morbidities in persons with neurogenic lower urinary tract dysfunction (NLUTD). They are associated with a significant morbidity and mortality, and they affect the quality of life of the affected patients. Diagnosis and treatment of UTI in this group of patients are challenging. In this review, the current strategies regarding diagnosis, treatment, and prevention are summarized. DIAGNOSTICS: it is important to correctly diagnose a UTI, as treatment of bacteriuria should strictly be avoided...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28721348/systematic-genetic-screening-in-a-prospective-group-of-danish-patients-with-pheochromocytoma
#19
Morten Steen Svarer Hansen, Niels Jacobsen, Anja Lisbeth Frederiksen, Lars Lund, Marianne Skovsager Andersen, Dorte Glintborg
Recent guidelines recommend consideration of genetic screening in all newly diagnosed patients with pheochromocytoma. Patients diagnosed with pheochromocytoma in the Region of Southern Denmark during 2006-2013 without previously recognized monogenetic etiology were offered genetic screening for mutations in the VHL, RET, SDHB, SDHC, and SDHD genes. A total of 41 patients were included, and genetic data were available in 35. In four of the 35 patients, a pathogenic variant was identified prior to the diagnosis of pheochromocytoma (von Hippel-Lindau disease, n=2; neurofibromatosis type 1, n=2)...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28685130/surgical-intervention-for-renal-cell-carcinoma-with-inferior-vena-cava-extension-combined-with-laparoscopic-procedure
#20
Toshio Kamimura, Kazutaka Kida, Masashi Takeda, Shunsuke Sato, Masato Fujii, Masahiro Inoue, Hiromasa Tsukino, Shoichiro Mukai, Atsushi Nanashima, Kunihide Nakamura, Toshiyuki Kamoto
Clear cell renal cell carcinoma (ccRCC) shows extreme hypervascularity, which may cause significant bleeding during surgery. For this reason, control of arterial blood supply is an important factor in the choice of operative procedure and in avoiding perioperative complications. This case series reports the successful dissection of renal artery in the preliminary stage of laparoscopic procedure in three ccRCC patients with inferior vena cava (IVC) extension. Patient 1 had right renal cell carcinoma (RCC) with level I tumor thrombus through two renal veins, and the renal artery was successfully dissected by retroperitonealscopic approach...
2017: Research and Reports in Urology
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