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Infection & Chemotherapy

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https://www.readbyqxmd.com/read/28608662/prosthetic-valve-endocarditis-caused-by-hacek-organisms-a-case-reports-and-systematic-review-of-the-literature
#1
Ha Na Choi, Ki Ho Park, Soyoung Park, Jae Min Kim, Hyun Joon Kang, Jae Hun Park, Mi Suk Lee
HACEK is a rare cause of prosthetic valve endocarditis (PVE). We describe 42-year-old male patient who presented with Aggregatibacter aphrophilus PVE and cerebral infarct. A. aphrophilus was isolated from his blood cultures as the sole pathogen, which was confirmed by subsequent 16S rRNA sequencing. He was treated with valve replacement surgery and an 8 week course of pathogen-directed antibiotic therapy and followed for 20 months without recurrence.
May 26, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28608661/campylobacter-jejuni-bacteremia-in-a-liver-cirrhosis-patient-and-review-of-literature-a-case-study
#2
Jin Gu Yoon, Saem Na Lee, Hak Jun Hyun, Min Joo Choi, Ji Ho Jeon, Eunju Jung, Seonghui Kang, Jeeyong Kim, Ji Yun Noh, Won Suk Choi, Joon Young Song, Hee Jin Cheong, Woo Joo Kim
Campylobacter infection causes gastrointestinal symptoms such as abdominal pain or diarrhea. Occasionally, Campylobacter bacteremia affects immunocompromised patients; however, serious outcomes are known to be rare. Here, we present a case of a patient with Campylobacter bacteremia who had underlying liver cirrhosis. The patient had fever and diarrhea. These symptoms subsided after treatment with cefotaxime. Campylobacter jejuni was isolated in the blood culture after 10 days. In addition, previously reported cases of Campylobacter bacteremia in Asian countries were reviewed with respect to antimicrobial sensitivities...
May 26, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28608658/massilia-varians-isolated-from-a-clinical-specimen
#3
Jooyoung Cho, Keon Han Kim, Jung Ok Kim, Jun Sung Hong, Seok Hoon Jeong, Kyungwon Lee
We report a case of Massilia varians isolated from a deep finger wound following orthopedic surgery on an immunocompetent patient. The bacterium was identified by 16S rDNA sequence analysis. This is the first case of M. varians isolated from a clinical specimen since the first report in 2008.
May 24, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28608657/maldi-tof-ms-fingerprinting-provides-evidence-of-urosepsis-caused-by-aerococcus-urinae
#4
Jieun Kim, Sung Kuk Hong, Myungsook Kim, Dongeun Yong, Kyungwon Lee
Urosepsis due to Aerococcus urinae is rare in clinical settings with only a few of reported cases worldwide by 16S rRNA sequencing. Here we report a case of sepsis caused by A. urinae in a 86 year-old male with complicated urinary tract infection which was confirmed through peptide mass fingerprinting of matrix-assisted laser desorption ionization time of flight mass spectrometry.
May 23, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28608656/primary-sternal-osteomyelitis-caused-by-staphylococcus-aureus-in-an-immunocompetent-adult
#5
Yu Na Jang, Hyung Sun Sohn, Sung Yeon Cho, Su Mi Choi
Primary sternal osteomyelitis (PSO) is a rare condition that may develop without any contiguous focus of infection. Due to the rarity of the disease, early diagnosis and appropriate treatment are often delayed. Herein, we describe a patient with PSO caused by Staphylococcus aureus that presented with chest pain and fever. The patient had no predisposing factors for sternal osteomyelitis. The chest pain was thought to be non-cardiogenic, as electrocardiography and cardiac enzyme did not reveal ischemic changes when he visited the emergency room...
May 23, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28681579/community-associated-methicillin-resistant-staphylococcus-aureus-in-nosocomial-infections
#6
EDITORIAL
Eun Ju Choo
No abstract text is available yet for this article.
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28681578/trend-in-cd4-cell-counts-at-diagnosis-in-human-immunodeficiency-virus-infected-persons-in-korea
#7
EDITORIAL
Nam Joong Kim
No abstract text is available yet for this article.
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28681577/tuberculous-meningitis-mimicking-varicella-zoster-meningitis
#8
Sun In Hong, Taeeun Kim, Jiwon Jung, Se Yoon Park, Yong Pil Chong, Sang Oh Lee, Sang Ho Choi, Yang Soo Kim, Jun Hee Woo, Sang Ahm Lee, Sung Han Kim
BACKGROUND: Varicella-zoster virus (VZV) is one of the most common etiologies of aseptic meningitis. The severest manifestation of VZV meningitis is occasionally confused with tuberculous meningitis (TBM). Thus, we investigated the clinical manifestations of VZV meningitis as compared with those of TBM. MATERIALS AND METHODS: All adult patients who were diagnosed with VZV meningitis or TBM were enrolled at a tertiary hospital in Seoul, South Korea, during an 8-year period...
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28681576/humoral-and-cellular-immunogenicity-induced-by-avian-influenza-a-h7n9-dna-vaccine-in-mice
#9
Eun Jin Choi, Han Sol Lee, Ji Yun Noh, Joon Young Song, Hee Jin Cheong, Ok Sarah Shin, Hyojin Lee, Moonsup Jeong, Woo Joo Kim
BACKGROUND: In March 2013, human infection with avian influenza A (H7N9) virus emerged in China, causing serious public health concerns and raising the possibility of avian-source pandemic influenza. Thus, the development of an effective vaccine for preventing and rapidly controlling avian influenza A (H7N9) virus is needed. In this study, we evaluated the immunogenicity of a synthetic DNA vaccine against H7 HA antigens in mice. MATERIALS AND METHODS: The synthetic consensus H7 HA DNA vaccine (25 or 50 μg) was administered to BALB/c mice at 0, 14, and 28 days by intramuscular injection followed by electroporation...
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28681575/an-update-on-zika-virus-in-asia
#10
REVIEW
Sl Ki Lim, Jacqueline Kyungah Lim, In Kyu Yoon
Zika virus (ZIKV) was first isolated in Asia from mosquitoes from Malaysia in 1966. However, the incidence of Zika and Zika-related neurological complications in Asia is not well known. The few studies of Zika in Asia have been inconsistent in pointing to likely transmission levels, with some studies suggesting substantial transmission and others not. Interpretation of existing epidemiological and public health data from Asia is constrained by the non-specific symptomatology of Zika, the high proportion of subclinical ZIKV infections, relatively low viremia, and the lack of accurate serological assays...
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28608665/comparison-of-plasma-concentrations-of-posaconazole-with-the-oral-suspension-and-tablet-in-korean-patients-with-hematologic-malignancies
#11
Hyeon Jeong Suh, Inho Kim, Joo Youn Cho, Sang In Park, Seo Hyun Yoon, Jeong Ok Lee, Youngil Koh, Kyoung Ho Song, Pyoeng Gyun Choe, Kyung Sang Yu, Eu Suk Kim, Hong Bin Kim, Soo Mee Bang, Nam Joong Kim, Sang Hoon Song, Wan Beom Park, Myoung Don Oh
The posaconazole tablet formulation was developed to have improved bioavailability compared to the oral suspension. Here, we compared posaconazole plasma concentration (PPC) with the posaconazole oral suspension versus the tablet in Korean patients undergoing remission induction chemotherapy for hematologic malignancies. PPC was measured at 3, 8, and 15 days of treatment with the oral suspension (174 patients) or the tablet (40 patients). At all time-points, mean PPC was significantly higher with the tablet compared to the oral suspension...
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28608664/trend-of-cd4-cell-counts-at-diagnosis-and-initiation-of-highly-active-antiretroviral-therapy-haart-korea-hiv-aids-cohort-study-1992-2015
#12
Min Jung Kim, Hyun Ha Chang, Sang Il Kim, Youn Jeong Kim, Dae Won Park, Chun Kang, Mee Kyung Kee, Ju Yeon Choi, Soo Min Kim, Bo Youl Choi, Woo Joo Kim, June Myung Kim, Jun Yong Choi, Young Hwa Choi, Jin Soo Lee, Shin Woo Kim
BACKGROUND: CD4+ cell counts reflect immunologic status of human immunodeficiency virus (HIV) patients. Recommended CD4+ cell counts for the initiation of highly active antiretroviral therapy (HAART) has increased over the past several years in various HIV treatment guidelines. We investigated the trend of CD4+ cell counts at diagnosis and treatment start using data from the Korea HIV/acquired immune deficiency syndrome (AIDS) Cohort Study. MATERIALS AND METHODS: The Korea HIV/AIDS Cohort Study started in 2006 and enrolled HIV patients from 21 tertiary and secondary hospitals in South Korea...
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28608663/enterovirus-infection-in-adults-presenting-with-nonspecific-febrile-illness-during-summer
#13
LETTER
Areum Durey, Young Su Je, Hea Yoon Kwon, Jae Hyoung Im, Ji Hyeon Baek, Sun Myoung Lee, Young Kyoung Park, Jin Soo Lee
No abstract text is available yet for this article.
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28608660/emergence-of-community-genotype-methicillin-resistant-staphylococcus-aureus-in-korean-hospitals-clinical-characteristics-of-nosocomial-infections-by-community-genotype-strain
#14
Eun Jeong Joo, Doo Ryeon Chung, So Hyun Kim, Jin Yang Baek, Nam Yong Lee, Sun Young Cho, Young Eun Ha, Cheol In Kang, Kyong Ran Peck, Jae Hoon Song
BACKGROUND: As community-genotype methicillin-resistant Staphylococcus aureus (MRSA) strains spread into hospitals, the genotypes of the MRSA strains causing hospital-acquired (HA) infections have become more diverse. We describe clinical characteristics of nosocomial MRSA infections by a community-genotype of sequence type (ST) 72. MATERIALS AND METHODS: A case-control study was designed among patients with HA-MRSA infections. Forty patients with infections caused by ST72-MRSA SCCmec type IV were selected as cases...
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28608659/is-the-initial-size-of-tuberculous-lymphadenopathy-associated-with-lymph-node-enlargement-during-treatment
#15
Yun Jae Seol, Se Yoon Park, Shi Nae Yu, Tark Kim, Eun Jung Lee, Min Huok Jeon, Eun Ju Choo, Tae Hyong Kim
There are little data on the changes in lymph node (LN) size during the treatment of tuberculous lymphadenopathy (TB LAP). This study aimed to provide data on LN changes during treatment. Between March 2014 and December 2015, 20 patients who were diagnosed with cervical TB LAP were enrolled. LN enlargement within two months (50%, 4/8 vs. 8.3%, 1/12; P = 0.04) was more frequently observed in patients with initial LN size ≥ 7.5 cm². Enlarged LNs were excised in three patients owing to pain and fistula formation...
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28271649/emphysematous-osteomyelitis-due-to-escherichia-coli
#16
Jinhee Lee, Chai Ho Jeong, Myun Hee Lee, Eun Gyo Jeong, Youn Jeong Kim, Sang Il Kim, Yang Ree Kim
Emphysematous osteomyelitis, especially that involving the extra-axial skeleton, is an extremely rare presentation but associated with significant morbidity and mortality. Here, we report a case in which a 58-year-old female patient with diabetes mellitus presented with emphysematous osteomyelitis that involved the sternum, clavicle, and pelvic bone and was caused by Escherichia coli via hematogenous spread of urinary tract infection. We successfully treated her with urgent and aggressive surgical drainage with prolonged antibiotics therapy...
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28271648/henoch-sch%C3%A3-nlein-purpura-with-concurrent-cytomegalovirus-duodenitis
#17
Sae Bom Shin, Yeong Jin Choi, Jieun Lee, Bong Gye Kwak, Yong Hee Kim, Kyung Sun Ha, Jin Hyoung Kang
Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving the small vessels with distinct clinical features. The etiology of HSP is diverse, and viral infection is one of the many predisposing factors. Cytomegalovirus (CMV) infection mostly affects immune-suppressed patients, but rarely patients with normal immunity can also be affected. Authors experienced a case of HSP patient, with underlying small-cell lung cancer (SCLC) with CMV duodenitis. This is a rare case of HSP diagnosed in SCLC patient with predisposing factor of CMV infection...
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28271644/a-case-of-disseminated-infection-with-skin-manifestation-due-to-non-neoformans-and-non-gattii-cryptococcus-in-a-patient-with-refractory-acute-myeloid-leukemia
#18
Sun Seob Park, Hyewon Lee, Weon Seo Park, Sang Hyun Hwang, Sang Il Choi, Mi Hong Choi, Si Won Lee, Eun Jung Ko, Young Ju Choi, Hyeon Seok Eom
Cryptococcus spp. other than Cryptococcus neoformans or Cryptococcus gattii were previously considered saprophytes and thought to be non-pathogenic to humans. However, opportunistic infections associated with non-neoformans and non-gattii species, such as Cryptococcus laurentii and Cryptococcus albidus, have increased over the past four decades. We experienced a case of cryptococcosis caused by non-neoformans and non-gattii spp. in a 47-year-old female with refractory acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation...
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28378540/mitochondrial-dysfunction-and-immune-cell-metabolism-in-sepsis
#19
REVIEW
Dae Won Park, Jaroslaw W Zmijewski
Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations of immune cells due to sepsis, as well as indicates plausible therapeutic opportunities...
March 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28332349/antimicrobial-stewardship-with-intravenous-to-oral-conversion-and-future-directions-of-antimicrobial-stewardship
#20
EDITORIAL
Shin Woo Kim
No abstract text is available yet for this article.
March 2017: Infection & Chemotherapy
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