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Infection & Chemotherapy

Eun Jung Kim, Eu Suk Kim
No abstract text is available yet for this article.
September 2018: Infection & Chemotherapy
Yang Ree Kim
No abstract text is available yet for this article.
September 2018: Infection & Chemotherapy
Hyo Suk Kim, Myun Hee Lee, Young Sun Kim, Jae Ki Choi, Jin Hong Yoo
Streptococcus suis is a zoonotic pathogen that can cause severe systemic infections in humans as well as swine. In recent decades, the number of S. suis infections in humans has increased, particularly in Southeast Asia. Although most cases of S. suis human infections are reported as sporadic, a few outbreaks have been noted. Interestingly, these outbreaks have been proposed to be associated with concomitant outbreaks in swine. In Korea, four sporadic and non-fatal cases of S. suis infection have been reported...
September 2018: Infection & Chemotherapy
Yong Kyun Kim, Kyeong Min Jo, Ji Hoon Jang, Chang Min Heo, Jae Ha Lee, Jin Han Park, Sunyoung Kim, Hang Jae Jang, Hyeon Kuk Kim, Sungmin Kiem
Emphysematous osteomyelitis, characterized by intraosseous gas, is a rare but potentially fatal condition that requires prompt diagnosis and aggressive therapy. Causative organisms are members of the bacterial family Enterobacteriaceae or anaerobes in most cases and significant comorbidities such as diabetes mellitus and malignancy, may predispose an individual to the development of emphysematous osteomyelitis. We report a case of extensive emphysematous osteomyelitis via hematogenous spread from Klebsiella pneumoniae liver abscess, complicated by gas-containing abscesses in adjacent soft tissues and epidural space, and multiple systemic septic emboli in a diabetic patient...
September 2018: Infection & Chemotherapy
Sang Ah Lee, Shin Woo Kim, Hyun Ha Chang, Hyejin Jung, Yoonjung Kim, Soyoon Hwang, Sujeong Kim, Han Ki Park, Jong Myung Lee
BACKGROUND: Dual regimen with dolutegravir plus cobicistat-boosted darunavir (DTG/DRV/c) is reasonable alternative option for patients with existing resistance and/or intolerance to nucleoside reverse transcriptase inhibitors (NRTIs). MATERIAL AND METHODS: All patients who switched to DTG/DRV/c among treatment-experienced patients with human immunodeficiency virus (HIV) in a tertiary university hospital were selected. We analyzed the effectiveness, safety, and tolerability based on serial laboratory data and clinical findings...
September 2018: Infection & Chemotherapy
Hyejin Jung, Shin Woo Kim, Hyun Ha Chang, Sang Ah Lee, Yoonjung Kim, Soyoon Hwang, Su Jeong Kim, Jong Myung Lee
BACKGROUND: Endogenous endophthalmitis (EE) is a fulminant ocular disease. This study was conducted to explore frequent pathogens and significant prognostic factors associated with poor ocular outcomes. MATERIALS AND METHODS: A retrospective analysis was performed in a tertiary hospital in Korea. Thirty-nine patients, treated between January 2000 and June 2017, were eligible for the analysis. Ocular outcomes were classified as follows: 1) no light perception (NLP), 2) light perception (LP), 3) hand motion (HM), 4) counting fingers (CF), and 5) 20/200 or better...
September 2018: Infection & Chemotherapy
Minoru Kobayashi, Toshitaka Uematsu, Gaku Nakamura, Hidetoshi Kokubun, Tomoya Mizuno, Hironori Betsunoh, Takao Kamai
BACKGROUND: Diabetes is considered a risk factor for acquisition of febrile urinary tract infection (f-UTI), but information on the association of diabetes with subsequent course of the disease is lacking. Thus, we investigated the clinical variables including diabetic status which determined the clinical course in patients with community-acquired f-UTI. MATERIALS AND METHODS: Patients hospitalized consecutively for f-UTI between February 2016 and January 2018 were used for this single center study...
September 2018: Infection & Chemotherapy
Sun Huh
BACKGROUND: In 2013, Infection & Chemotherapy changed the main language of its articles to English so that they could be submitted to PubMed Central. This study presents the recent status of journal metrics for Infection & Chemotherapy and introduces scholarly journal publishing policies or guidelines that have recently appeared. MATERIALS AND METHODS: A variety of journal metrics were analyzed based on the Web of Science Core Collection, including the nationality of authors the proportion of funded articles to Journal Articles , manually calculated impact factor, the titles of journals in which articles were cited", and the Hirsch index...
September 2018: Infection & Chemotherapy
Jae Bum Jun
Since the mid 1980s, the prevalence of liver abscess caused by hypervirulent Klebsiella pneumoniae strain has increased in Asia, particularly in Taiwan and Korea. This strain is mostly K1 or K2 serotype, and has hypercapsular and hypermucoid phenotypes. Most infections are community acquired, and patients rarely have a hepatobiliary disease prior to infection. Clinical manifestations are characterized by fever and high C-reactive protein, and metastatic infections, such as septic emboli in the lung and endophthalmitis and meningitis are frequently observed...
September 2018: Infection & Chemotherapy
Kyung Hwa Park, Robin Patel
Prosthetic joint infection (PJI) poses a burden on patients and health care resources. PJI diagnosis can be challenging, owing to imperfect definition, alongside inadequate diagnostic techniques. In this review, we describe consensus definitions of PJI, approaches to diagnosis using methods available in Korea, and novel diagnostic methods.
September 2018: Infection & Chemotherapy
Mi Suk Lee, Jee Youn Oh, Cheol In Kang, Eu Suk Kim, Sunghoon Park, Chin Kook Rhee, Ji Ye Jung, Kyung Wook Jo, Eun Young Heo, Dong Ah Park, Gee Young Suh, Sungmin Kiem
Community-acquired pneumonia is common and important infectious disease in adults. This work represents an update to 2009 treatment guideline for community-acquired pneumonia in Korea. The present clinical practice guideline provides revised recommendations on the appropriate diagnosis, treatment, and prevention of community-acquired pneumonia in adults aged 19 years or older, taking into account the current situation regarding community-acquired pneumonia in Korea. This guideline may help reduce the difference in the level of treatment between medical institutions and medical staff, and enable efficient treatment...
June 2018: Infection & Chemotherapy
Jae Ki Choi, Sung Yeon Cho, Su Mi Choi, Gyo Hui Kim, Sung Eun Lee, Seok Lee, Dong Wook Kim, Dong Gun Lee
Dasatinib, a tyrosine kinase inhibitor, is widely used for patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Although the drug has a potent immunosuppressive effect, infectious complications during dasatinib treatment have been reported rarely. We describe five patients who developed cytomegalovirus (CMV) colitis during dasatinib treatment, in whom the colitis was initially confused with other causes. The patients, three with chronic myeloid leukemia, and two with acute lymphoblastic leukemia, were diagnosed with CMV colitis based on endoscopic and histologic findings...
June 2018: Infection & Chemotherapy
Jee Young Lee, Yongduk Jeon, Mi Young Ahn, Hea Won Ann, In Young Jung, Wooyong Jung, Moo Hyun Kim, Jin Young Ahn, Je Eun Song, Yong Chan Kim, Dong Hyun Oh, Eun Jin Kim, Su Jin Jeong, Nam Su Ku, Hyunsoo Kim, Kyungwon Lee, June Myung Kim, Jun Yong Choi
Brucellosis is a zoonotic infection that is usually transmitted from cattle to humans through ingestion of animal milk, direct contact with animal parts, or inhalation of aerosolized particles. In Korea, brucellosis seem to be transmitted through close contact with blood, fetus, urine, and placenta of domestic cow that has been infected by Brucella abortus, or inhalation of B. arbortus while examining or slaughtering cow. Brucella melitensis infection is rare in Korea and there have been no reported cases of B...
June 2018: Infection & Chemotherapy
Ka Young Kim, Jae Hyun Cho, Chang Min Yu, Kyung Jin Lee, Jae Min Lee, Seokyoung Koh, Mingu Kwon, Dasol Jeong
Kocuria kristinae, part of the normal flora of the skin and oral mucosa, is seldom reported as a human pathogen; infection is mostly associated with immunocompromised patients in healthcare facilities. Here, we describe the first case of bacteremic empyema caused by K. kristinae acquired from the community. K. kristinae was isolated from pleural effusion and two sets of peripheral blood samples drawn from two different sites. The empyema resolved after the insertion of a chest tube and intravenous administration of piperacillin-tazobactam and levofloxacin...
June 2018: Infection & Chemotherapy
Se Eun Go, Kyung Jin Lee, Yaeni Kim, Jae Ki Choi, Yoo Jin Kim, Dong Gun Lee
Because primary antifungal prophylaxis is widely used for immunocompromised hosts, the incidences of unusual fungal infections have increased. Trichosporon asahii has emerged as an important life-threatening opportunistic systemic pathogen because of the increased use of cytotoxic or immunosuppressant agents, along with high mortality rates. Here, we describe a case of catheter-related T. asahii bloodstream infection with multiple septic skin nodules in both the arms and legs of the patient who was in the neutropenic period after allogeneic stem cell transplantation for myelodysplastic syndrome treated with prophylactic ciprofloxacin and itraconazole...
June 2018: Infection & Chemotherapy
So Yeon Park, Joong Sik Eom, Jin Seo Lee, Young Su Ju, Ji Young Park
BACKGROUND: The emergence of multidrug-resistant, Gram-negative bacteria has resulted in reconsideration of colistimethate sodium (CMS) as a last resort for treatment of such infections. However, acute kidney injury (AKI) may represent a major limiting adverse effect of use of CMS. Early AKI detection in CMS-treated patients can help prevent progression to acute failure and reduce the need of renal replacement therapy. We hypothesized that plasma neutrophil gelatinase-associated lipocalin (NGAL) may be an early biomarker of AKI in CMS-treated patients...
June 2018: Infection & Chemotherapy
Yo Han Park
BACKGROUND: Yeoncheon is an endemic region for hemorrhagic fever with renal syndrome (HFRS) and has been reporting HFRS cases intermittently in other seasons, including autumn. This study was conducted to determine whether a seasonal variation pattern of HFRS exists in Yeoncheon. MATERIALS AND METHODS: From 2002 to 2016, raw data of the number of patients with HFRS in Yeoncheon and nationwide was collected from the Korea Center for Disease Control and Prevention...
June 2018: Infection & Chemotherapy
Tark Kim, Heungsup Sung, Yong Pil Chong, Sung Han Kim, Eun Ju Choo, Sang Ho Choi, Tae Hyong Kim, Jun Hee Woo, Yang Soo Kim, Sang Oh Lee
BACKGROUND: Trimethoprim/sufamethoxazole (TMP/SMX) is the recommended treatment for Pneumocystis jirovecii pneumonia (PCP). However, the efficacy and the safety of alternative salvage treatments are less guarauteed especially when patient experiences treatment failure and/or an adverse drug reactions (ADR). The purpose of this study is to recognize potential risk factors imitating successful treatment with TMP/SMX among PCP patients. MATERIALS AND METHODS: Ninety one adult patients diagnosed with PCP were included after searching electronical medical records from January 2013 through July 2015 at Asan Medical Center Seoul, Korea...
June 2018: Infection & Chemotherapy
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