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Journal of Cardiovascular and Thoracic Research

Panagiotis Kalogris, Kosmas Iliadis, Gregory Amanatidis, Alexandros Demis, Anna Smyrli, Konstantinos Petsios
We describe a case of a 43-year old woman with Marfan's syndrome, tricuspid valve regurgitation and severe pectus excavatum who required an aortic root replacement and valvuloplasty for an ascending aortic aneurism with aortic valve regurgitation and tricuspid valve regurgitation. There was a severe angulation of the sternum which was close to 1.5 cm to the column vertebrae. Such cases are quite rare and always a challenge for surgeons to achieve adequate exposure of the heart and prevent excessive cardiac compression...
2018: Journal of Cardiovascular and Thoracic Research
Mustafa Houmsse, Asia McDavid, Ahmet Kilic
An ascending aortic thrombus is a rare source for embolic transient ischemic attack (TIA) or stroke without an associated aortic pathology. Here we describe a case of a patient who presented with generalized symptoms of headache and fatigue who, on subsequent work-up , was found to have an ascending aortic thrombus with no obvious associated aortic pathology, and was successfully treated with apixaban, a newer direct oral anticoagulant.
2018: Journal of Cardiovascular and Thoracic Research
Ahmad Separham, Mohsen Abbasnezhad, Golnesa Shahnazarli, Alireza Khoshbahar
Introduction: Cancer antigen 125 (CA-125) is a tumor marker of ovarian cancer, which has shown to be increased in different cardiovascular diseases. Although the prognostic role of CA-125 in heart failure and coronary heart disease is well-established, there is little known about its role in acute myocardial infarction (AMI). In this study we aimed to evaluate the serum levels of CA-125 in patients with AMI and its prognostic role in evaluating the in-hospital outcome of AMI. Methods: We evaluated 120 male patients with AMI and 120 male normal subjects...
2018: Journal of Cardiovascular and Thoracic Research
Saeid Komasi, Ali Soroush, Mozhgan Saeidi, Agostino Brugnera, Massimo Rabboni, Mario Fulcheri, Danilo Carrozzino, Paolo Marchettini, Angelo Compare
Introduction: The causal attributions and perceived risk factors can affect patients' health behaviors. Therefore, the present study aimed to assess (i) the effect of an outpatient cardiac rehabilitation (CR) program on perceived heart risk factors (PHRFs) and on psychological stress, and (ii) the role of changes of PHRFs at pre-post CR in predicting changes in psychological stress. Methods: In this longitudinal study, 110 CR patients were assessed from June to November 2016 in a hospital in Iran. Perceived heart risk factors and perceived stress were investigated using the PHRFs scale and the Depression, Anxiety, Stress Scale-21, respectively...
2018: Journal of Cardiovascular and Thoracic Research
Vajihe Izadi, Ahmad Esmaillzadeh, Mahin Hashemipour, Pamela J Surkan, Leila Azadbakht, Roya Kelishadi
Introduction: Limited information exists regarding the effects of high protein (HP) diets on cardiovascular disease (CVD) risk factors among overweight and obese children. Our aim was to determine the effects of an HP diet on anthropometric indexes and CVD risk factors among overweight and obese children. Methods: In a parallel randomized controlled trial, we recruited 50 overweight and obese children, aged 6-11 years, for a 10 week HP or control diet (protein, carbohydrate, fat: 25%, 45%, 30% in the HP diet vs...
2018: Journal of Cardiovascular and Thoracic Research
Sahand Hamidi, Javad Kojuri, Armin Attar, Jamshid Roozbeh, Alireza Moaref, Mohammad Hossein Nikoo
Introduction: Cardiac dysfunction is a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). Previous studies have shown that kidney transplantation can reverse some of the gross changes in the myocardial structure such as left ventricular ejection fraction (LVEF) and volumes. Whether kidney transplantation can reverse the subtle and early myocardial changes in ESRD patients who do not suffer from gross alternations in myocardial function is not yet studied. The aim of this study was to answer this question...
2018: Journal of Cardiovascular and Thoracic Research
Sohrab Minaei Beyrami, Mohammad Hasan Khadem Ansari, Yousef Rasemi, Nader Shakib, Pouran Karimi
Introduction: Lipid phosphatase and tensin homolog deleted from chromosome 10 (PTEN) antagonizes phosphoinositide 3-kinase (PI3K)/AKT cell survival pathway. The effect of PTEN inhibitors has been rarely examined on cell survival following reperfusion injury. In this study, we investigated the neuroprotective effect of SF1670, as a new PTEN inhibitor, on an in vitro stroke-like model. Methods: PC12 cells were exposed to oxygen-glucose deprivation/reperfusion (OGD/R). The cells were treated in five conditions as follows: normoxic normoglycemic (NO/NG); 60 minutes OGD; 60 minutes OGD and 6 h reperfusion (OGD/R); OGD/R treated with 10 µM SF1670 (OGD/R-SF), and NO/NG treated with 10 µM SF1670 (NO/NG-SF)...
2018: Journal of Cardiovascular and Thoracic Research
Mohammad Esmaeil Motlagh, Mostafa Qorbani, Amir-Masood Rafiemanzelat, Majzoubeh Taheri, Tahereh Aminaee, Gita Shafiee, Zeinab Ahadi, Mahshid Hajiali, Kimia Ghaderi, Ali Safaei, Azam Goodarzi, Hasan Ziaodini, Ramin Heshmat, Roya Kelishadi
Introduction: This study presents the prevalence of cardiometabolic risk factors in a nationally representative sample of Iranian children and adolescents. Methods: This multi-centric study was conducted in 2015 among 4200 students aged 7-18 years. They were selected by multistage cluster sampling from 30 provinces of Iran. Anthropometric indices, biochemical and clinical parameters were measured. Results: The mean of weight, height, waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting blood glucose (FBG) was higher in boys than in girls ( P < 0...
2018: Journal of Cardiovascular and Thoracic Research
Muriela Silva, Eduarda Pereira, Afonso Rocha, Dulce Sousa, Bruno Peixoto
Introduction: Prospective studies have shown the relation between acute coronary syndrome (ACS) and neurocognitive dysfunction with prevalence ranging between 10.51% and 66.8%. The present study aims to determine the prevalence level of neurocognitive dysfunction; the relations between sociodemographic, clinical and emotional variables and neurocognitive functioning in a sample of ACS patients. Methods: The sample comprised of 53 patients engaged in cardiac rehabilitation within 3 months after an ACS. Patients with any medical history of neuropsychiatric problems prior to the ACS and illiterate subjects were not included in the study...
2018: Journal of Cardiovascular and Thoracic Research
Jamal Hallajzadeh, Maliheh Khoramdad, Nahid Karamzad, Amir Almasi-Hashiani, Ali Janati, Erfan Ayubi, Reza Pakzad, Mark J M Sullman, Saeid Safiri
Introduction: The objectives of this study were to provide an estimate of the prevalence of metabolic syndrome (MetS ) and its components among women with PCOS; and calculate the odds ratio (OR) for MetS (using different definitions of MetS) in women with PCOS, compared to healthy controls. Methods: All of the relevant databases were used to search for appropriate articles that were published during the period 2003-2016. We included observational studies (cross-sectional, comparative cross-sectional) among women who met the inclusion criteria...
2018: Journal of Cardiovascular and Thoracic Research
Aayush Goyal, Rohit Shahapurkar, Balaji Aironi, Ninad Kotkar, Ankur Goel
Pericardial effusion after midline cardiac surgery may be transudative or exudative. The exudative infective or haemorrhagic variety requires early surgical intervention. However there are rare cases of collections like chylomediastinum which should be ruled out. Their low incidence prompts to establish protocol for evaluating postoperative pericardial collections, which includes echocardiography and biochemical analysis of aspirate. The same is important from the perspective of management as chylopericardium may be successfully managed without surgical intervention by aspiration, pig tail insertion, dietary and medical management, which we demonstrate through our rare case which occurred after midline double valve replacement...
2018: Journal of Cardiovascular and Thoracic Research
Fardin Mirbolouk, Mahboobeh Gholipour, Arsalan Salari, Maryam Shakiba, Jalal Kheyrkhah, Vahid Nikseresht, Nozar Sotoudeh, Negar Moghadam, Mohammad Jaafar Mirbolouk, Mani Moayeri Far
Introduction: No-reflow is one of the major complications of primary PCI in patients with acute ST elevation myocardial infarction. This phenomenon is associated with adverse outcomes in these patients. In the current study, we evaluated the effectiveness of CHA2DS2-VASc score in predicting no-reflow phenomenon. CHA2DS2-VASc score is a risk stratification method to estimate the risk of thromboembolism in patients with atrial fibrillation. Methods: In total, 396 patients with ST elevation myocardial infarction who had undergone primary PCI were evaluated in our study...
2018: Journal of Cardiovascular and Thoracic Research
Mehri Khatami, Mohammad Mehdi Heidari, Fatemeh Kazeminasab, Razieh Zare Bidaki
Introduction: Congenital heart diseases (CHDs) are structural cardiovascular malformations that arise from abnormal development of the heart during the prenatal life. Mutations in the TBX5 gene, encoding T-box transcription factor, are a major cause of CHD. To evaluate the TBX5 mutations in hotspot exons in sporadic pediatric patients with CHD phenotypes, analytical case/control study performed in an Iranian cohort of unrelated patients with clinical diagnosis of congenital heart malformations. Methods: We investigated TBX5 coding exons 4, 5, 6 and 7 in 95 sporadic patients with CHD phenotypes and compared to 82 healthy controls using PCR-SSCP and DNA sequencing approaches...
2018: Journal of Cardiovascular and Thoracic Research
Seyed Morteza Shamshirgaran, Hamid Barzkar, Darioush Savadi-Oskouei, Mohammad Yazdchi Marandi, Abdolrasoul Safaiyan, Ehsan Sarbazi, Hossein Novbakht, Saber Gaffari
Introduction: Stroke is one of the important causes of death and disability in Iran. This study aimed to examine the factors influencing the short-term mortality of stroke in Northwest of Iran. Methods: Study population were all patients with confirming the diagnosis of the first-ever stroke who were hospitalized in two referral teaching hospitals from October 2013 to March 2015. They were followed up to 30 days after onset of stroke. A neurology year three resident was responsible for extracting the clinical data and assessment of stroke severity on admission using National Institute of Health Stroke Scale (NIHSS), and information about risk factors and socio-demographic factors were collected using face to face interview...
2018: Journal of Cardiovascular and Thoracic Research
Vladimir A Shvartz, Anton R Kiselev, Anatoly S Karavaev, Kristina A Vulf, Ekaterina I Borovkova, Mikhail D Prokhorov, Andrey D Petrosyan, Olga L Bockeria
Introduction: Our aim was to perform a comparative study of short-term cardiovascular autonomic control in cardiac surgery patients who underwent coronary artery bypass grafting (CABG) or surgical correction of valvular heart disease (SCVHD ). Methods: The synchronous 15 minutes records of heart rate variability (HRV) and finger's photoplethysmographic waveform variability (PPGV) were performed in 42 cardiac surgery patients (12 women) aged 61.8 ± 8.6 years (mean ± standard deviation), who underwent CABG, and 36 patients (16 women) aged 54...
2018: Journal of Cardiovascular and Thoracic Research
Mehdi Nosratabadi, Zohreh Halvaiepour
Introduction: Evaluating patient satisfaction with self-care program can increase the likelihood of complying with treatment. There is no valid and reliable tool to be used in measuring Iranian patient's satisfaction with self-care program. So, this study intends to develop the patient satisfaction questionnaire in the context of cardiac rehabilitation and test its validity and reliability in Iranian patients. Methods: A cross-sectional study was conducted to develop and validate the patient satisfaction with self-care program questionnaire using structural modeling...
2018: Journal of Cardiovascular and Thoracic Research
Morteza Bagheri, Kamal Khadem-Vatani, Mir Hossein Seyed Mohammad Zad, Isa Abdi Rad, Behzad Rahimi, Alireza Rostamzadeh, Mojtaba Godarzi, Shabnam Ashena
Introduction: Premature coronary heart disease (PCHD) affects public health and leads to death. PCHD has several genetic and environmental risk factors. The aim of this study was to analysis of the mutations in exon 10 of MEFV gene in patients with PCHD in West Azerbaijan province of Iran. Methods: Totally 41 PCHD patients who were admitted to the cardiology unit of Sayedoshohada hospital (Urmia, Iran) enrolled in the study. Selection of the patients was done based on the strict criteria, that is, who had a minimum of one angiographically documented coronary artery with the stenosis of 50%...
2018: Journal of Cardiovascular and Thoracic Research
Yaseen Rashidi, Hesam Manaflouyan, Fatemeh Pournaghi Azar, Zeinab Nikniaz, Leila Nikniaz, Samad Ghaffari
Introduction: This study aimed at evaluating knowledge and awareness of hypertension and the risk factors for hypertension among hypertensive patients. Methods: In this study, 110 hypertensive patients were enrolled and filled out two self-administered questionnaires. The first questionnaire was about the demographic characteristics and the second one was about the knowledge (n = 10), attitude (n = 9) and practice (n = 8). The internal consistency and the stability of the questionnaires were approved. The Mann-Whitney U test and Kruskal-Wallis and Spearman correlation coefficient were used for statistical analysis...
2018: Journal of Cardiovascular and Thoracic Research
Seyyed Hossein Hassanpour, Mohammad Amin Dehghani, Seyyedeh Zeinab Karami
The relentlessly beating heart has the greatest oxygen consumption of any organ in the body at rest reflecting its huge metabolic turnover and energetic demands. The vast majority of its energy is produced and cycled in form of ATP which stems mainly from oxidative phosphorylation occurring at the respiratory chain in the mitochondria. A part from energy production, the respiratory chain is also the main source of reactive oxygen species and plays a pivotal role in the regulation of oxidative stress. Dysfunction of the respiratory chain is therefore found in most common heart conditions...
2018: Journal of Cardiovascular and Thoracic Research
Akram Sadeghi, Mohsen Setayesh Mehr, Ebrahim Esfandiari, Shabnam Mohammadi, Hamid Baharmian
Cephalic and basilic veins begin their path from around the wrist and continue towards the area above the forearm. The basilic vein becomes deep around the mid-arm, while the cephalic vein becomes deep around the upper forearm, in deltopectoral groove. The superficial veins are most commonly used for vein puncture, transfusion, bypass graft, and cardiac catheterization. In renal patients, the basilic vein use as an arteriovenous graft or fistula for haemodialysis access. During a routine dissection in the department of anatomy in Isfahan, we observed a variation in the left arm of an infant boy (six months old)...
2017: Journal of Cardiovascular and Thoracic Research
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