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Toxicological Research

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https://www.readbyqxmd.com/read/30057701/proteomic-changes-in-chick-brain-proteome-post-treatment-with-lathyrus-sativus-neurotoxin-%C3%AE-n-oxalyl-l-%C3%AE-%C3%AE-diaminopropionic-acid-l-odap-a-better-insight-to-transient-neurolathyrism
#1
D Anil Kumar, Sumathi Natarajan, Nabil A M Bin Omar, Preeti Singh, Rohan Bhimani, Surya Satyanarayana Singh
Neurolathyrism is a neurodegenerative disorder characterized by spastic paraplegia resulting from the excessive consumption of Lathyrus sativus (Grass pea). β-N-Oxalyl-L-α,β-diaminopropionic acid (L-ODAP) is the primary neurotoxic component in this pea. The present study attempted to evaluate the proteome-wide alterations in chick brain 2 hr and 4 hr post L-ODAP treatment. Proteomic analysis of chick brain homogenates revealed several proteins involved in cytoskeletal structure, signaling, cellular metabolism, free radical scavenging, oxidative stress and neurodegenerative disorders were initially up-regulated at 2 hr and later recovered to normal levels by 4 hr...
July 2018: Toxicological Research
https://www.readbyqxmd.com/read/30057700/genotoxicity-study-of-glycopeptide-g-7-nana
#2
Ha-Young Kim, Min-Hee Kim, Hee-Kyong Kim, Yeong-Chul Park
Glycomacropeptide (GMP), a whey protein of milk, has functions including differentiation and development of nervous system, and anticancer and antiviral effects. To develop new functions, N-acetylneuraminic acid (NANA) containing 7% sialic acid was separated from GMP to produce G-7%NANA. N-glycolylneuraminic acid (Neu5Gc) is another type of sialic acid separated from GMP, which has been linked to immune disorders and chronic inflammation-mediated diseases. Therefore, safety was a concern in the use of G-7%NANA in functional foods...
July 2018: Toxicological Research
https://www.readbyqxmd.com/read/30057699/role-of-glutathione-redox-system-on-the-t-2-toxin-tolerance-of-pheasant-phasianus-colchicus
#3
Csaba Fernye, Zsolt Ancsin, Andrea Bócsai, Krisztián Balogh, Miklós Mézes, Márta Erdélyi
The purpose of the present study was to evaluate the effects of different dietary concentrations of T-2 toxin on blood plasma protein content, lipid peroxidation and glutathione redox system of pheasant ( Phasianus colchicus ). A total of 320 one-day-old female pheasants were randomly assigned to four treatment groups fed with a diet contaminated with different concentrations of T-2 toxin (control, 4 mg/kg, 8 mg/kg and 16 mg/kg). Birds were sacrificed at early (12, 24 and 72 hr) and late (1, 2 and 3 weeks) stages of the experiment to demonstrate the effect of T-2 toxin on lipid peroxidation and glutathione redox status in different tissues...
July 2018: Toxicological Research
https://www.readbyqxmd.com/read/30057698/lactobacillus-aggravate-bile-duct-ligation-induced-liver-inflammation-and-fibrosis-in-mice
#4
Yoon Seok Roh, Ara Cho, Youn-Soo Cha, Suk-Heung Oh, Chae Woong Lim, Bumseok Kim
Lactobacillus (LAB) have been reported to exert both harmful and beneficial effects on human and animal health. Recently, it has been reported that dysbiosis and bacterial translocation contribute to liver fibrosis. However, the role of Gram-positive LAB in the situation of chronic liver diseases has not been yet elucidated. Liver injury was induced by bile duct ligation (BDL) in LAB or control-administered mice. Liver fibrosis was enhanced in LAB-administered mice compared with control-treated mice as demonstrated by quantification of Sirius-red positive area, hydroxyproline contents and fibrosis-related genes (Col1α1, Acta2, Timp1, Tgfb1)...
July 2018: Toxicological Research
https://www.readbyqxmd.com/read/30057697/modulatory-role-of-selenium-and-vitamin-e-natural-antioxidants-against-bisphenol-a-induced-oxidative-stress-in-wistar-albinos-rats
#5
Wahiba Amraoui, Nesrine Adjabi, Fatiha Bououza, Mahieddine Boumendjel, Faiza Taibi, Amel Boumendjel, Cherif Abdennour, Mahfoud Messarah
Bisphenol A, an everywhere chemical, is applied as a plasticizer in polycarbonate plastics, which often used in our everyday products and in epoxy resins as protective coatings and linings for food and beverage cans for decades. Human exposure to BPA may lead to adverse effects by interfering with oestrogen receptors. Our present study was conducted to investigate the protective effects of selenium (Se) and vitamin E (Vit E) on BPA-induced damage in the liver of male rats. Animals were randomly divided into four groups: the first group received olive oil and served as control...
July 2018: Toxicological Research
https://www.readbyqxmd.com/read/30057696/investigating-organ-toxicity-profile-of-tenofovir-and-tenofovir-nanoparticle-on-the-liver-and-kidney-experimental-animal-study
#6
Aniekan Imo Peter, Edwin Cs Naidu, Edidiong Akang, Oluwatosin O Ogedengbe, Ugochukwu Offor, Sanjeev Rambharose, Rahul Kalhapure, Anil Chuturgoon, Thirumala Govender, Onyemaechi O Azu
Tenofovir nanoparticles are novel therapeutic intervention in human immunodeficiency virus (HIV) infection reaching the virus in their sanctuary sites. However, there has been no systemic toxicity testing of this formulation despite global concerns on the safety of nano drugs. Therefore, this study was designed to investigate the toxicity of Tenofovir nanoparticle (NTDF) on the liver and kidney using an animal model. Fifteen adult male Sprague-Dawley (SD) rats maintained at the animal house of the biomedical resources unit of the University of KwaZulu-Natal were weighed and divided into three groups...
July 2018: Toxicological Research
https://www.readbyqxmd.com/read/30057695/oxidative-stress-in-extrahepatic-tissues-of-rats-co-exposed-to-aflatoxin-b1-and-low-protein-diet
#7
Oluwakemi A Rotimi, Solomon O Rotimi, Flora Oluwafemi, Oladipo Ademuyiwa, Elizabeth A Balogun
Early life exposure to aflatoxin B1 (AFB1) and low protein diet through complementary foods during weaning is common in parts of Africa and Asia. This study evaluated the effect of co-exposure to AFB1 and low protein diet on the extrahepatic tissues of rats. Twenty-four three-week old weanling male albino rats were used for this study and were randomly assigned into four groups: group 1 served as control and was fed normal protein diet (20% protein), group 2 was fed low protein diet (5% protein), group 3 was fed normal protein diet + 40 ppb AFB1 while group 4 received low protein diet + 40 ppb AFB1, all for eight weeks...
July 2018: Toxicological Research
https://www.readbyqxmd.com/read/30057694/metabolic-profiling-of-eccentric-exercise-induced-muscle-damage-in-human-urine
#8
Hyun-Jun Jang, Jung Dae Lee, Hyun-Sik Jeon, Ah-Ram Kim, Suhkmann Kim, Ho-Seong Lee, Kyu-Bong Kim
Skeletal muscle can be ultrastructurally damaged by eccentric exercise, and the damage causes metabolic disruption in muscle. This study aimed to determine changes in the metabolomic patterns in urine and metabolomic markers in muscle damage after eccentric exercise. Five men and 6 women aged 19~23 years performed 30 min of the bench step exercise at 70 steps per min at a determined step height of 110% of the lower leg length, and stepping frequency at 15 cycles per min. 1 H NMR spectral analysis was performed in urine collected from all participants before and after eccentric exercise-induced muscle damage conventionally determined using a visual analogue scale (VAS) and maximal voluntary contraction (MVC)...
July 2018: Toxicological Research
https://www.readbyqxmd.com/read/30057693/a-collaborative-study-to-establish-the-second-korean-national-reference-standard-for-snake-venom
#9
Kiwon Han, Kikyung Jung, Hokyung Oh, Hojin Song, Sangmi Park, Ji-Hye Kim, Garam Min, Byung-Hwa Lee, Hyun-Sik Nam, Yang Jin Kim, Manabu Ato, Jayoung Jeong, Chiyoung Ahn
In 2015, a candidate for the second national reference standard (NRS) of Gloydius snake venom was produced to replace the first NRS of Gloydius snake venom. In the present study, the potencies of the candidate were determined by a collaborative study, and the qualification of the candidate was estimated. The potencies of the candidate were determined by measuring the murine lethal titers and lapine hemorrhagic titers of venom against the regional working reference standard (RWRS) for antivenom using the methods described in the previous report for the first NRS of Gloydius snake venom...
July 2018: Toxicological Research
https://www.readbyqxmd.com/read/30057692/systemic-and-local-anaphylaxis-is-not-induced-by-korean-red-ginseng-mixture-in-guinea-pigs
#10
Sun Hee Hyun, Jong Soo Kyung, Yong Bum Song, Seung-Ho So, Young Sook Kim
Currently, injuries to customers due to health functional foods are annually increasing. To evaluate the antigenicity of Korean red ginseng mixture (KRGM), we tested for systemic anaphylactic shock and passive cutaneous anaphylaxis in guinea pigs. Based on a comparison of measured body weights, there were no changes in body weight for the KRGM treatment group compared with the control group. In the ovalbumin treated group, however, there was a statistically significant decrease in body weight. For the active systemic anaphylaxis test, after the induction, there were no symptoms that suggested anaphylactic shock in the control and KRGM treatment group...
July 2018: Toxicological Research
https://www.readbyqxmd.com/read/29686779/valproic-acid-exposure-of-pregnant-rats-during-organogenesis-disturbs-pancreas-development-in-insulin-synthesis-and-secretion-of-the-offspring
#11
Komariah Komariah, Wasmen Manalu, Bambang Kiranadi, Adi Winarto, Ekowati Handharyani, M Orliando Roeslan
Valproic acid (VPA) plays a role in histone modifications that eventually inhibit the activity of histone deacetylase (HDAC), and will affect the expressions of genes Pdx1, Nkx6.1, and Ngn3 during pancreatic organogenesis. This experiment was designed to study the effect of VPA exposure in pregnant rats on the activity of HDAC that controls the expression of genes regulating the development of beta cells in the pancreas to synthesize and secrete insulin. This study used 30 pregnant Sprague-Dawley rats, divided into 4 groups, as follows: (1) a control group of pregnant rats without VPA administration, (2) pregnant rats administered with 250 mg VPA on day 10 of pregnancy, (3) pregnant rats administered with 250 mg VPA on day 13 of pregnancy, and (4) pregnant rats administered with 250 mg VPA on day 16 of pregnancy...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29686778/comparison-of-mutagenic-activities-of-various-ultra-fine-particles
#12
Chang Gyun Park, Hyun Ki Cho, Han Jae Shin, Ki Hong Park, Heung Bin Lim
Air pollution is increasing, along with consumption of fossil fuels such as coal and diesel gas. Air pollutants are known to be a major cause of respiratory-related illness and death, however, there are few reports on the genotoxic characterization of diverse air pollutants in Korea. In this study, we investigated the mutagenic activity of various particles such as diesel exhaust particles (DEP), combustion of rice straw (RSC), pine stem (PSC), and coal (CC), tunnel dust (TD), and road side dust (RD). Ultra-fine particles (UFPs) were collected by the glass fiber filter pad...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29686777/anti-diabetic-effects-of-dung-beetle-glycosaminoglycan-on-db-mice-and-gene-expression-profiling
#13
Mi Young Ahn, Ban Ji Kim, Hyung Joo Yoon, Jae Sam Hwang, Kun-Koo Park
Anti-diabetes activity of Catharsius molossus (Ca, a type of dung beetle) glycosaminoglycan (G) was evaluated to reduce glucose, creatinine kinase, triglyceride and free fatty acid levels in db mice. Diabetic mice in six groups were administrated intraperitoneally: Db heterozygous (Normal), Db homozygous (CON), Heuchys sanguinea glycosaminoglycan (HEG, 5 mg/kg), dung beetle glycosaminoglycan (CaG, 5 mg/kg), bumblebee ( Bombus ignitus ) queen glycosaminoglycan (IQG, 5 mg/kg) and metformin (10 mg/kg), for 1 month...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29686776/vanadate-induced-renal-camp-and-malondialdehyde-accumulation-suppresses-alpha-1-sodium-potassium-adenosine-triphosphatase-protein-levels
#14
Somchit Eiam-Ong, Yuyen Nakchui, Mookda Chaipipat, Somchai Eiam-Ong
It has been demonstrated that vanadate causes nephrotoxicity. Vanadate inhibits renal sodium potassium adenosine triphosphatase (Na, K-ATPase) activity and this is more pronounced in injured renal tissues. Cardiac cyclic adenosine monophosphate (cAMP) is enhanced by vanadate, while increased cAMP suppresses Na, K-ATPase action in renal tubular cells. There are no in vivo data collectively demonstrating the effect of vanadate on renal cAMP levels; on the abundance of the alpha 1 isoform (α1 ) of the Na, K-ATPase protein or its cellular localization; or on renal tissue injury...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29686775/beneficial-effects-of-cynaroside-on-cisplatin-induced-kidney-injury-in-vitro-and-in-vivo
#15
Jong-Hyun Nho, Ho-Kyung Jung, Mu-Jin Lee, Ji-Hun Jang, Mi-Ok Sim, Da-Eun Jeong, Hyun-Woo Cho, Jong-Choon Kim
Anti-cancer drugs such as cisplatin and doxorubicin are effectively used more than radiotherapy. Cisplatin is a chemotherapeutic drug, used for treatment of various forms of cancer. However, it has side effects such as ototoxicity and nephrotoxicity. Cisplatin-induced nephrotoxicity increases tubular damage and renal dysfunction. Consequently, we investigated the beneficial effect of cynaroside on cisplatin-induced kidney injury using HK-2 cell (human proximal tubule cell line) and an animal model. Results indicated that 10 μM cynaroside diminished cisplatin-induced apoptosis, mitochondrial dysfunction and caspase-3 activation, cisplatin-induced upregulation of caspase-3/MST-1 pathway decreased by treatment of cynaroside in HK-2 cells...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29686774/determination-of-ethanol-in-blood-samples-using-partial-least-square-regression-applied-to-surface-enhanced-raman-spectroscopy
#16
Güneş Açikgöz, Berna Hamamci, Abdulkadir Yildiz
Alcohol consumption triggers toxic effect to organs and tissues in the human body. The risks are essentially thought to be related to ethanol content in alcoholic beverages. The identification of ethanol in blood samples requires rapid, minimal sample handling, and non-destructive analysis, such as Raman Spectroscopy. This study aims to apply Raman Spectroscopy for identification of ethanol in blood samples. Silver nanoparticles were synthesized to obtain Surface Enhanced Raman Spectroscopy (SERS) spectra of blood samples...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29686773/permitted-daily-exposure-for-diisopropyl-ether-as-a-residual-solvent-in-pharmaceuticals
#17
Luca Romanelli, Maria Grazia Evandri
Solvents can be used in the manufacture of medicinal products provided their residual levels in the final product comply with the acceptable limits based on safety data. At worldwide level, these limits are set by the "Guideline Q3C (R6) on impurities: guideline for residual solvents" issued by the ICH. Diisopropyl ether (DIPE) is a widely used solvent but the possibility of using it in the pharmaceutical manufacture is uncertain because the ICH Q3C guideline includes it in the group of solvents for which "no adequate toxicological data on which to base a Permitted Daily Exposure (PDE) was found"...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29686772/effects-of-7-mega-tm-500-on-oxidative-stress-inflammation-and-skin-regeneration-in-h-2-o-2-treated-skin-cells
#18
In-Bong Song, Hyejung Gu, Hye-Ju Han, Na-Young Lee, Ji-Yun Cha, Yeon-Kyong Son, Jungkee Kwon
Environmental stimuli can lead to the excessive accumulation of reactive oxygen species (ROS), which is one of the risk factors for premature skin aging. Here, we investigated the protective effects of 7-MEGATM 500 (50% palmitoleic acid, 7-MEGA) against oxidative stress-induced cellular damage and its underlying therapeutic mechanisms in the HaCaT human skin keratinocyte cell line (HaCaT cells). Our results showed that treatment with 7-MEGA prior to hydrogen peroxide (H2 O2 )-induced damage significantly increased the viability of HaCaT cells...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29686771/oral-wound-healing-effects-of-acai-berry-water-extracts-in-rat-oral-mucosa
#19
Mi Hyun Kang, Bae-Hwan Kim
The objective of this study was to determine the oral wound healing effects of acai berry water extracts (ABWE) in rat oral mucosa. To estimate the anti-oxidative effects of ABWE, the contents of phenolic compounds, and DPPH (1,1-diphenyl-2-picryl hydrazyl) and ABTS (2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) abilities were evaluated. Wound healing effects of ABWE were tested following 6-day exposure after induction of wound by applying 50% acetic acid to oral mucosa of Sprague-Dawley rats. Macroscopic and histopathological analyses were performed to determine wound healing effects of ABWE...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29686770/subacute-oral-toxicity-assesment-of-ethanol-extract-of-mariposa-christia-vespertilionis-leaves-in-male-sprague-dawley-rats
#20
Syahirah Ahmad Sayuti Nurul, Hamzah Hazilawati, Rosly Shaari Mohd, Farhan Hanif Reduan Mohd, Mohamed Mustapha Noordin, Md Esa Norhaizan
The term Butterfly tea refers to decoction of Mariposa christia vespertilionis leaves which is widely consumed by cancer patients throughout Malaysia and has gained a huge popularity among Malaysians, not only cancer patients but also researchers to discover the real potential of this plant. Herein, the study is aimed at evaluating the possible toxicity in 28-day subacute oral toxicity of ethanolic extract M. christia vespertilionis in male Sprague Dawley rats. The 28-day subacute toxicity study was conducted to detect the no-observed adverse effect level (NOAEL)...
April 2018: Toxicological Research
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