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Toxicological Research

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https://www.readbyqxmd.com/read/29377025/erratum-to-anti-inflammatory-effect-of-3-bromo-4-5-dihydroxybenzaldehyde-a-component-of-polysiphonia-morrowii-in-vivo-and-in-vitro-toxicol-res-33-2017-325-332
#1
Na-Jin Kang, Sang-Chul Han, Hyun-Jae Kang, Geum Ko, Weon-Jong Yoon, Hee-Kyoung Kang, Eun-Sook Yoo
[This corrects the article on p. 325 in vol. 33, PMID: 29071017.].
January 2018: Toxicological Research
https://www.readbyqxmd.com/read/29372004/mental-stress-from-animal-experiments-a-survey-with-korean-researchers
#2
Minji Kang, AhRam Han, Da-Eun Kim, Troy Seidle, Kyung-Min Lim, SeungJin Bae
Animal experiments have been widely conducted in the life sciences for more than a century, and have long been a subject of ethical and societal controversy due to the deliberate infliction of harm upon sentient animals. However, the harmful use of animals may also negatively impact the mental health of researchers themselves. We sought to evaluate the anxiety level of researchers engaged in animal use to analyse the mental stress from animal testing. The State Anxiety Scale of the State-Trait Anxiety Inventory (STAI) was used to evaluate how researchers feel when they conduct animal, as opposed to non-animal, based experiments (95 non-animal and 98 animal testing researchers)...
January 2018: Toxicological Research
https://www.readbyqxmd.com/read/29372003/pretreatment-of-low-dose-and-super-low-dose-lps-on-the-production-of-in-vitro-lps-induced-inflammatory-mediators
#3
Byeong Suk Chae
Pretreatment of low-dose lipopolysaccharide (LPS) induces a hyporesponsive state to subsequent secondary challenge with high-dose LPS in innate immune cells, whereas super-low-dose LPS results in augmented expression of pro-inflammatory cytokines. However, little is known about the difference between super-low-dose and low-dose LPS pretreatments on immune cell-mediated inflammatory and hepatic acute-phase responses to secondary LPS. In the present study, RAW 264.7 cells, EL4 cells, and Hepa-1c1c7 cells were pretreated with super-low-dose LPS (SL-LPS: 50 pg/mL) or low-dose LPS (L-LPS: 50 ng/mL) in fresh complete medium once a day for 2~3 days and then cultured in fresh complete medium for 24 hr or 48 hr in the presence or absence of LPS (1~10 μg/mL) or concanavalin A (Con A)...
January 2018: Toxicological Research
https://www.readbyqxmd.com/read/29372002/subchronic-oral-dose-toxicity-study-of-enterococcus-faecalis-2001-ef-2001-in-mice
#4
Yeun-Hwa Gu, Takenori Yamasita, Ki-Mun Kang
As a part of general toxicity studies of Enterococcus Faecalis 2001 (EF 2001) prepared using heat-treatment bacillus mort body EF 2001 in mice, this study examined the toxicity of EF 2001 in single and repeated administrations following the previous report in order to apply this product to preventive medicine. The safety of oral ingestion of EF 2001 was examined in 6-week-old male and female ICR mice with 1,000 mg/kg, 3,000 mg/kg and 5,000 mg/kg body weight/day administrated by gavage of the maximum acceptable dose of EF 2001...
January 2018: Toxicological Research
https://www.readbyqxmd.com/read/29372001/subacute-inhalation-toxicity-of-cyclohexanone-in-b6c3f1-mice
#5
Yong-Hoon Lee, Yong Hyun Chung, Hyeon-Yeong Kim, Seo Ho Shin, Sang Bae Lee
Cyclohexanone (C6H10O, CAS No. 108-94-1) is a colorless oily liquid obtained through the oxidation of cyclohexane or dehydrogenation of phenol. It is used in the manufacture of adhesives, sealant chemicals, agricultural chemicals, paint and coating additives, solvent, electrical and electronic products, paints and coatings, photographic supplies, film, photochemicals, and as an intermediate in nylon production. Owing to the lack of information on repeated inhalation toxicity of cyclohexaone, in this study, we aimed to characterize the subacute inhalation toxicity...
January 2018: Toxicological Research
https://www.readbyqxmd.com/read/29372000/highly-active-antiretroviral-therapy-alters-sperm-parameters-and-testicular-antioxidant-status-in-diet-induced-obese-rats
#6
Ibukun P Oyeyipo, Bongekile T Skosana, Frans P Everson, Hans Strijdom, Stefan S du Plessis
The efficacy of highly active antiretroviral therapy (HAART) has led to an increase demand for therapeutic use, thereby necessitating investigation into drug toxicity. This study was designed to investigate the in vivo effects of HAART on sperm parameters and testicular oxidative stress in lean and obese rats. Wistar rats (males, n = 40, weighing 180~200 g) were assigned randomly into 4 groups and treated accordingly for 16 weeks as follows: Control (C): lean group fed with standard rat chow; Diet induced obesity (DIO): obese animals fed a high caloric diet; C + ART: lean animals treated with HAART; DIO + ART: obese animals treated with HAART...
January 2018: Toxicological Research
https://www.readbyqxmd.com/read/29371999/antioxidant-and-skin-anti-aging-effects-of-marigold-methanol-extract
#7
Chul Ho Kang, Sung Ja Rhie, Young Chul Kim
The objective of this study was to evaluate the antioxidant and anti-aging effects of marigold methanol extract (MGME) in human dermal fibroblasts. Total polyphenolic and flavonoid contents in MGME were 74.8 mg TAE (tannic acid equivalent)/g and 85.6 mg RE (rutin equivalent)/g, respectively. MGME (500 μg/mL) increased 1,1-diphenyl-2-picryl hydrazyl (DPPH) and 2,2'-azino-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical-scavenging, and superoxide dismutase (SOD)-like antioxidant activities by 36.5, 54.7, and 14...
January 2018: Toxicological Research
https://www.readbyqxmd.com/read/29371998/protective-effect-of-isoliquiritigenin-against-ethanol-induced-hepatic-steatosis-by-regulating-the-sirt1-ampk-pathway
#8
Ann-Yae Na, Eun-Ju Yang, Ju Mi Jeon, Sung Hwan Ki, Kyung-Sik Song, Sangkyu Lee
Ethanol-induced fat accumulation, the earliest and most common response of the liver to ethanol exposure, may be involved in the pathogenesis of liver diseases. Isoliquiritigenin (ISL), an important constituent of Glycyrrhizae Radix, is a chalcone derivative that exhibits antioxidant, anti-inflammatory, and phytoestrogenic activities. However, the effect of ISL treatment on lipid accumulation in hepatocytes and alcoholic hepatitis remains unclear. Therefore, we evaluated the effect and underlying mechanism of ISL on ethanol-induced hepatic steatosis by treating AML-12 cells with 200 mM ethanol and/or ISL (0~50 μM) for 72 hr...
January 2018: Toxicological Research
https://www.readbyqxmd.com/read/29371997/inhibition-of-adipocyte-differentiation-by-anthocyanins-isolated-from-the-fruit-of-vitis-coignetiae-pulliat-is-associated-with-the-activation-of-ampk-signaling-pathway
#9
Min Ho Han, Hong Jae Kim, Jin-Woo Jeong, Cheol Park, Byung Woo Kim, Yung Hyun Choi
Anthocyanins are naturally occurring water-soluble polyphenolic pigments in plants that have been shown to protect against cardiovascular diseases, and certain cancers, as well as other chronic human disorders. However, the anti-obesity effects of anthocyanins are not fully understood. In this study, we investigated the effects of anthocyanins isolated from the fruit of Vitis coignetiae Pulliat on the adipogenesis of 3T3-L1 preadipocytes. Our data indicated that anthocyanins attenuated the terminal differentiation of 3T3-L1 preadipocytes, as confirmed by a decrease in the number of lipid droplets, lipid content, and triglyceride production...
January 2018: Toxicological Research
https://www.readbyqxmd.com/read/29371996/molecular-mechanism-of-atopic-dermatitis-induction-following-sensitization-and-challenge-with-2-4-dinitrochlorobenzene-in-mouse-skin-tissue
#10
JiYoun Kim, JaeHee Lee, SoJung Shin, AhRang Cho, Yong Heo
Laboratory animal models have been developed to investigate preventive or therapeutic effect of medicinal products, or occurrence or progression mechanism of atopic dermatitis (AD), a pruritic and persistent inflammatory skin disease. The murine model with immunologic phenomena resembling human AD was introduced, which demonstrated skewedness toward predominance of type-2 helper T cell reactivity and pathophysiological changes similar as human AD following 2,4-dinitrochlorobenzene (DNCB) sensitization and challenge...
January 2018: Toxicological Research
https://www.readbyqxmd.com/read/29371995/fluorescence-detection-of-cell-death-in-liver-of-mice-treated-with-thioacetamide
#11
Jin Seok Kang
The purpose of this study was to detect cell death in the liver of mice treated with thioacetamide (TAA) using fluorescence bioimaging and compare this outcome with that using conventional histopathological examination. At 6 weeks of age, 24 mice were randomly divided into three groups: group 1 (G1), control group; group 2 (G2), fluorescence probe control group; group 3 (G3), TAA-treated group. G3 mice were treated with TAA. Twenty-two hours after TAA treatment, G2 and G3 mice were treated with Annexin-Vivo 750...
January 2018: Toxicological Research
https://www.readbyqxmd.com/read/29071019/lamivudine-therapy-exacerbates-bilirubinemia-in-patients-underlying-severely-advanced-hepatitis
#12
Young Hee Choi, Chang Ho Lee, Myong Suk Ko, Hyun Joo Han, Sang Geon Kim
Lamivudine belongs to the set of antiviral agents effective against hepatitis B virus infection. Given case reports on liver injuries after certain antiviral agent treatments, this study examined the effects of lamivudine on alanine aminotransferase (ALT) and total bilirubin (TB) using a medical system database. A total of 1,321 patients taking lamivudine alone or with others were evaluated using laboratory hits in an electronic medical system at Seoul National University Hospital from 2005 through 2011. The patients were grouped according to prior ALT results: G#1, ALT < 40 IU/L; G#2, 40 IU/L ≤ ALT < 120 IU/L; G#3, 120 IU/L ≤ ALT < 240 IU/L; and G#4, ALT ≥ 240 IU/L...
October 2017: Toxicological Research
https://www.readbyqxmd.com/read/29071018/a-90-day-inhalation-toxicity-study-of-ethyl-formate-in-rats
#13
Mi Ju Lee, Hyeon-Yeong Kim
Ethyl formate, a volatile solvent, has insecticidal and fungicidal properties and is suggested as a potential fumigant for stored crop and fruit. Its primary contact route is through the respiratory tract; however, reliable repeated toxicological studies focusing on the inhalation route have not been published to date. Therefore, the present study was conducted to investigate the safety of a 90-day repeated inhalation exposure in rats. Forty male and 40 female rats were exposed to ethyl formate vapor via inhalation at concentrations of 0, 66, 330, and 1,320 ppm for 6 hr/day, 5 days a week for 13 weeks...
October 2017: Toxicological Research
https://www.readbyqxmd.com/read/29071017/anti-inflammatory-effect-of-3-bromo-4-5-dihydroxybenzaldehyde-a-component-of-polysiphonia-morrowii-in-vivo-and-in-vitro
#14
Na-Jin Kang, Sang-Chul Han, Hyun-Jae Kang, Geum Ko, Weon-Jong Yoon, Hee-Kyoung Kang, Eun-Sook Yoo
3-Bromo-4,5-dihydroxybenzaldehyde (BDB) is a natural bromophenol compound that is most commonly isolated from red algae. The present study was designed to investigate the anti-inflammatory properties of BDB on atopic dermatitis (AD) in mice induced by 2,4-dinitrochlorobenzene (DNCB) and on lipopolysaccharide (LPS)-stimulated murine macrophages. BDB treatment (100 mg/kg) resulted in suppression of the development of AD symptoms compared with the control treatment (induction-only), as demonstrated by reduced immunoglobulin E levels in serum, smaller lymph nodes with reduced thickness and length, a decrease in ear edema, and reduced levels of inflammatory cell infiltration in the ears...
October 2017: Toxicological Research
https://www.readbyqxmd.com/read/29071016/environmental-exposure-of-sperm-sex-chromosomes-a-gender-selection-technique
#15
Ibukun P Oyeyipo, Michelle van der Linde, Stefan S du Plessis
Preconceptual sex selection is still a highly debatable process whereby X- and Y-chromosome-bearing spermatozoa are isolated prior to fertilization of the oocyte. Although various separation techniques are available, none can guarantee 100% accuracy. The aim of this study was to separate X- and Y-chromosome-bearing spermatozoa using methods based on the viability difference between the X- and Y-chromosome-bearing spermatozoa. A total of 18 experimental semen samples were used, written consent was obtained from all donors and results were analysed in a blinded fashion...
October 2017: Toxicological Research
https://www.readbyqxmd.com/read/29071015/comparative-in-vitro-biological-toxicity-of-four-kinds-of-air-pollution-particles
#16
Han-Jae Shin, Hyun Gi Cho, Chang Kyun Park, Ki Hong Park, Heung Bin Lim
Accumulating epidemiological evidence indicates that exposure to fine air pollution particles (APPs) is associated with a variety of adverse health effects. However, the exact physiochemical properties and biological toxicities of fine APPs are still not well characterized. We collected four types of fine particle (FP) (diesel exhaust particles [DEPs], natural organic combustion [NOC] ash, synthetic organic combustion [SOC] ash, and yellow sand dust [YSD]) and investigated their physicochemical properties and in vitro biological toxicity...
October 2017: Toxicological Research
https://www.readbyqxmd.com/read/29071014/chelation-of-thallium-iii-in-rats-using-combined-deferasirox-and-deferiprone-therapy
#17
Samie Salehi, Amir Sh Saljooghi, Somayeh Badiee, Mojtaba Mashmool Moqadam
Thallium and its compounds are a class of highly toxic chemicals that cause wide-ranging symptoms such as gastrointestinal disturbances; polyneuritis; encephalopathy; tachycardia; skin eruptions; hepatic, renal, cardiac, and neurological toxicities; and have mutagenic and genotoxic effects. The present research aimed to evaluate the efficacy of the chelating agents deferasirox (DFX) and deferiprone (L1) in reducing serum and tissue thallium levels after the administration of thallium (III), according to two different dosing regimens, to several groups of Wistar rats for 60 days...
October 2017: Toxicological Research
https://www.readbyqxmd.com/read/29071013/recommended-rice-intake-levels-based-on-average-daily-dose-and-urinary-excretion-of-cadmium-in-a-cadmium-contaminated-area-of-northwestern-thailand
#18
Aroon La-Up, Phongtape Wiwatanadate, Sakda Pruenglampoo, Sureeporn Uthaikhup
This study was performed to investigate the dose-response relationship between average daily cadmium dose (ADCD) from rice and the occurrence of urinary cadmium (U-Cd) in individuals eating that rice. This was a retrospective cohort designed to compare populations from two areas with different levels of cadmium contamination. Five-hundred and sixty-seven participants aged 18 years or older were interviewed to estimate their rice intake, and were assessed for U-Cd. The sources of consumed rice were sampled for cadmium measurement, from which the ADCD was estimated...
October 2017: Toxicological Research
https://www.readbyqxmd.com/read/29071012/suppression-of-primary-splenocyte-proliferation-by-artemisia-capillaris-and-its-components
#19
Hye Eun Lee, Gabsik Yang, Jae Sue Choi, Joo Young Lee
The host immune system is the first line of host defense, consisting mainly of innate and adaptive immunity. Immunity must be maintained, orchestrated, and harmonized, since overactivation of immune responses can lead to inflammation and autoimmune diseases, while immune deficiency can lead to infectious diseases. We investigated the regulation of innate and adaptive immune cell activation by Artemisia capillaris and its components (ursolic acid, hyperoside, scopoletin, and scopolin). Macrophage phagocytic activity was determined using fluorescently labeled Escherichia coli, as an indicator of innate immune activation...
October 2017: Toxicological Research
https://www.readbyqxmd.com/read/29071011/cancer-chemopreventive-potential-of-procyanidin
#20
REVIEW
Yongkyu Lee
Chemoprevention entails the use of synthetic agents or naturally occurring dietary phytochemicals to prevent cancer development and progression. One promising chemopreventive agent, procyanidin, is a naturally occurring polyphenol that exhibits beneficial health effects including anti-inflammatory, antiproliferative, and antitumor activities. Currently, many preclinical reports suggest procyanidin as a promising lead compound for cancer prevention and treatment. As a potential anticancer agent, procyanidin has been shown to inhibit the proliferation of various cancer cells in "in vitro and in vivo"...
October 2017: Toxicological Research
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