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Iranian Journal of Pharmaceutical Research: IJPR

Siamak Aghlmand, Bahlol Rahimi, Hamidreza Farrokh-Eslamlou, Bahram Nabilou, Hassan Yusefzadeh
Among non-oil and in trade arena, drug has always been strategic importance and most government especially industrialized countries pay special attention to its production and trade issues. Thus, having a comprehensive view from economic perspective to this section is essential for suggesting intervention. This was a descriptive-analytical and panel study. In this study, gravity model is used to estimate Iran's bilateral intra-industry trade in pharmaceutical products in the 2001-2012 periods. To illustrate the extent of pharmaceutical's intra-industry trade between Iran and its major trading partners, the explanatory variables of market size, income, factor endowments, distance, cultural contributions, and similarities and also special trade arrangements have been applied...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Gloria Shalviri, Bahareh Yazdizadeh, Fariba Mirbaha, Kheirollah Gholami, Reza Majdzadeh
Adverse drug events (ADEs) may cause serious injuries including death. Spontaneous reporting of ADEs plays a great role in detection and prevention of them; however, underreporting always exists. Although several interventions have been utilized to solve this problem, they are mainly based on experience and the rationale for choosing them has no theoretical base. The vast variety of behavioural theories makes it difficult to choose appropriate theory. Theoretical domains framework (TDF) is suggested as a solution...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Mouhamad Hasan Pourrashid, Farzaneh Dastan, Jamshid Salamzadeh, Alireza Eslaminejad, Maryam Edalatifard
Burden of Chronic Obstructive Pulmonary Disease (COPD) is substantial and increasing in the world. There are controversial reports regarding vitamin D supplementation in COPD. We investigated relationship between vitamin D3 (Cholecalciferol) supplementation with Health Related Quality of Life (HRQOL) and symptom recovery in AECOPD patients with concurrent Vitamin D Deficiency (VDD). A placebo-controlled randomized clinical trial was designed. AECOPD patients with VDD were randomly allocated to receive either vitamin D 300,000 IU (n = 35) or placebo (n = 35) by intramuscular injection...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Kayvan Saeedfar, Mehrdad Behmanesh, Esmaeil Mortaz, Mohammad Reza Masjedi
The response to glucocorticoids (GCs) therapy classifies severe refractory asthma (SRA) and mild asthma, so the glucocorticoid receptors (GCRs) gene expression may be involved in SRA pathogenesis. Thus, it is aimed to compare the expression levels of two GCR isoforms (GCRα and GCRβ) in SRA, mild asthmatics, and healthy controls. Total RNA was isolated from the peripheral blood mononuclear lymphocytes of 13 SRA patients, 14 mild asthma patients and 30 healthy volunteers. The expression levels of GCR isoforms were evaluated using quantitative real-time polymerase chain reaction (qRT-PCR)...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Omid Hesami, Mohammad Reza Shams, Ladan Ayazkhoo, Farhad Assarzadegan, Behnam Safarpour Lima, Hosein Delavar Kasmaei, Mohammad Sistanizad
Patients suffering from headache, particularly migraine type, are among the most dissatisfied patients. The aim of this study was comparing the efficacy of pregabalin with valproate sodium, in preventing migraine headache. In a randomized, double-blinded study, adult patients eligible for prophylactic treatment ( i.e. , patients with 4-15 attacks per month in last two months) were recruited. Patients' demographic data, duration of symptoms, headache frequency (attacks per month) and intensity (based on visual analogue scale) and also drugs used to relief headache were recorded...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Yalda Hosseinzadeh Ardakani, Hoda Lavasani, Mohammad-Reza Rouini
The stereoselective pharmacokinetic of Tramadol (T) and its main metabolites concerning the influence of CYP2D6 phenotype and gender on the phase I metabolism of this compound was studied after administration of 100 mg single oral dose of racemic T to 24 male and female subjects. The pharmacokinetic parameters were estimated from plasma concentrations of the analytes enantiomers. The metabolic ratio of T enantiomers was used for CYP2D6 phenotype determination. The plasma concentrations of both tramadol enantiomers were considerably higher in Poor metabolizers (PM) than in extensive metabolizers (EM), resulting in 43% and 37% increase in AUC values of (+)-T and (-)-T respectively...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Mohammad Ali Khosravi Zanjani, Mohammad Reza Ehsani, Babak Ghiassi Tarzi, Anousheh Sharifan
Microencapsulation with hydrocolloids as a modern technique has been used to prolong the survival of probiotics during exposure to harsh conditions. In this study, alginate-Hylon starch microcapsules with genipin cross-linked chitosan and poly-L-lysine coatings were developed to encapsulate four strains of probiotic bacteria, including Lactobacillus casei (ATCC 39392), Bifidobacterium bifidum (ATCC 29521), Lactobacillus rhamnosus (ATCC 7469), and Bifidobacterium adolescentis (ATCC 15703). The viability of probiotics was investigated under heat treatment (72, 85, and 90 °C, 0...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Hossein Safarpour, Morteza Shahmirzaie, Elham Rezaee, Mahmood Barati, Mohammad Reza Safarnejad, Farshad H Shirazi
Tumor necrosis factor alpha (TNF-α) expression amplifies to excess amounts in several disorders such as rheumatoid arthritis and psoriasis. Although, Anti-TNF biologics have revolutionized the treatment of these autoimmune diseases, formation of anti-drug antibodies (ADA) has dramatically affected their use. The next generation antibodies ( e.g. Fab, scFv) have not only reduced resulted immunogenicity, but also proved several benefits including better tumor penetration and more rapid blood clearance. Using affinity selection procedures in this study, a scFv antibody clone was isolated from naïve Tomlinson I phage display library that specifically recognizes and binds to TNF-α...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Fatemeh Ghasemi, Hanieh Tamadon, Narges Hosseinmardi, Mahyar Janahmadi
Epilepsy is a chronic neurological disease which disrupts the neuronal electrical activity. One-third of patients are resistant to treatment with available antiepileptic agents. The use of herbal medicine for treating several diseases including epilepsy is on the rise. Therefore, further investigation is required to verify the safety and effectiveness of Phytomedicine in treating diseases. The current study is an attempt to elucidate the electrophysiological mechanism of the effect of Dorema ammoniacum gum on a cellular model of epilepsy, using intracellular recording method...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Lei Yin, Enshuang Guan, Yuanbin Zhang, Zhiheng Shu, Bing Wang, Xiuli Wu, Jing Chen, Jingxia Liu, Xueyan Fu, Weihong Sun, Meifeng Liu
Glycyrrhiza uralensis Fisch. ( G. uralensis ) is one of the most widely used herbal medicines. This study was designed to enrich total flavonoids (TFF) from G. uralensis . The chemical profile of TFF was identified by HPLC and colorimetric assay. The TFF mainly contained liquiritin apioside, liquiritin, isoliquiritin apioside, liquiritigenin and isoliquiritigenin without glycyrrhizic acid. To study the anti-inflammatory activity of TFF, the DMB-induced ear vasodilatation assay and carrageenan-induced rat paw edema model have been utilized...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Hamid Moloudian, Sepideh Abbasian, Nasser Nassiri-Koopaei, Mohammad Reza Tahmasbi, Golnaz Alsadat Afzal, Maryam Sadat Ahosseini, Masud Yunesian, Mohammad Reza Khoshayand
In the present study, the physicochemical properties and antioxidant activities of different Iranian honey samples are investigated using various multivariate techniques in order to develop a quality control model. Forty-eight Iranian honey samples were tested for 15 physicochemical and antioxidant parameters. The parameters for which the samples were tested included color intensity, moisture, electrical conductivity, pH, free acidity, diastase activity, hydroxymethylfurfural content, proline level, total phenolic content, antioxidant activity, and radical scavenging activity...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Nanis G Allam, Ehab Mostafa M Ali, Samya Shabanna, Elsayed Abd-Elrahman
Cadmium (Cd) is a highly toxic heavy metal, wide occupational and an environmental pollutant, affecting human health. Probiotics especially lactic acid bacteria (LAB) have the capacity to bind, remove and to decrease tissue cadmium levels. The objective was to evaluate the potency of Cd binding capacity, antioxidative properties of probiotic bacteria against cadmium in-vitro and its probable detoxification effect against Cd-induced toxicity in mice. To asses this objective, resistance against cadmium and antioxidative properties (via DPPH radical scavenging and inhibition of lipid peroxidation) were estimated for thirteen probiotic bacteria...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Elhameh Nikkhah, Fariba Heshmati Afshar, Hossein Babaei, Parina Asgharian, Abbas Delazar
Scrophularia umbrosa is a medicinal plant used as a traditional herb. This study was designed to investigate the phytochemical analysis of methanol (MeOH), DCM, and n-Hexane extracts of rhizome as well as total phenol and total flavonoid contents (TPC and TFC). In-vitro β-hematin formation assay and DPPH method were applied for analyzing antimalarial and free-radical scavenging activities of the extracts, respectively. The formation of hemozoin has been proposed as an ideal drug target for antimalarial screening programs...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Nurten Ozsoy, Tugba Yilmaz-Ozden, Pinar Aksoy-Sagirli, Hasan Şahin, Aynur Sarı
In this study, antioxidant, antiacetylcholinesterase, anti-inflammatory, and DNA protecting activities of the aerial parts of Glaucium grandiflorum var. grandiflorum were evaluated. The lyophilized methanolic extract of the aerial parts of G. grandiflorum var. grandiflorum was investigated for potential in-vitro antioxidant properties in thiobarbituric acid test using the lipid peroxidation of liposomes, ferric ion reducing antioxidant power (FRAP), 1,1-diphenyl-2-picrylhydrazyl,2,2'-azinobis(3-ethylbenzothiazoline-6-sulphonate) free-radicals and hypochlorous acid scavenging assays...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Fariba Heshmati Afshar, Abbas Delazar, Solmaz Asnaashari, Haleh Vaez, Elmira Zolali, Parina Asgharian
Scrophularia genus belonging to the family of Scrophulariaceae, is a medicinal plant widely distributed in Iran. In the present study, the anti-malarial activity of different extracts of three Iranian endemic species of Scrophularia including S. frigida , S. subaphylla and S. atropatana , was screened by an in-vitro preliminary assay. The plant materials were extracted successively with n-hexane, dichloromethane (DCM), and methanol (MeOH) at room temperature by soxhlet extractor. In order to assess anti-malarial activity of obtained extracts, cell free β-hematin formation assay was applied...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Samira Dodangeh, Maryam Niyyati, Mohammad Kamalinejad, Jacob Lorenzo-Morales, Abdolali Moshfe, Ali Haghighi, Eznolah Azargashb
Acanthamoeba keratitis (AK) is a sight-threatening infection of the cornea disease that often presents with a lengthy and not fully effective treatment. Current therapeutic options against Acanthamoeba are not very effective against the cyst. Calibrated trophozoite/cyst suspension was incubated with the same volume of serial dilutions of the Trigonella foenum graecum aqueous extract (200, 250, 350, 450, 600, and 750 mg/mL) in microcentrifuge tubes and mixed by pipetting up and down. After that, the tubes were incubated at 26 ºC for 24, 48, and 72 h...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Trinh Tat Cuong, Giang Huy Diem, Tran Trung Doan, Nguyen Quang Huy, Nguyen Phuong, Hoang The Hung
Wedelolactone is known to have biological activities such as anti-inflammation hepatitis, anti-hepatotoxic activity, and trypsin inhibitory effect. However, up to date, there has not been any deep study on the role of wedelolactone for zymosan-induced signaling pathways in the process of regulating the excessive inflammatory responses in host. Here, we demonstrated that wedelolactone plays an essential role for regulation of zymosan-induced inflammatory responses in murine bone marrow-derived macrophages (BMDMs)...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Sharareh Sharifi, Pargol Ghavam Mostafavi, Ali Mashinchian Moradi, Mohammad Hadi Givianrad, Hassan Niknejad
Marine Soft corals have frequently been studied in recent years because of their specific chemical compounds in tissue engineering and regenerative medicine. The aim of this study was to investigate anti-cancer property of extracted compound from Virgularia gustaviana and their effect on inducing of apoptosis. The extraction process was carried out with ethyl acetate for 5 days and the extract was separated by silica-gel column chromatography. The column was washed with n-hexane-ethyl acetate solvent at ratio of 10:0 to 0:10...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Javad Baharara, Tayebe Ramezani, Nasrein Hosseini, Marzieh Mousavi
The biosynthesis of nanoparticles is widely considered today. This investigation was aimed at the biosynthesis and coating of Ag.NPs with Zataria multiflora ( Zm- Ag.NPs) leaf extract and assessment of its apoptosis promoting effects. The Zm -Ag.NPs was characterized by UV-visible and FTIR spectroscopy, TEM, EDS, DLS, and measurement of zeta-potential. Apoptosis induction effects of Zm- Ag.NPs were assessed using acridine orange - propidium iodide ( AO/PI), DAPI staining, caspase3/9 activation assay, and annexinV/PI assay...
2018: Iranian Journal of Pharmaceutical Research: IJPR
James Oluwagbamigbe Fajemiroye, Keasling Adam, Zjawiony Jordan K, Costa Elson Alves, Adeleke Adesiyan Aderoju
The search for psychoactive plants possessing therapeutic potential in the treatment of anxiety and depression has attracted growing interest. One such plant, Nymphaea lotus (commonly known as water lily), is used in traditional medicine for analgesic and sedative effects. The present study sought to assess the anti-anxiety and antidepressant activities of crude leaf extract of N. lotus and determine possible mechanisms of action. Barbiturate sleep induction, rota-rod, light/dark box, elevated plus maze, forced swimming test (FST) and open field test (OFT) were conducted...
2018: Iranian Journal of Pharmaceutical Research: IJPR
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