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Iranian Journal of Pharmaceutical Research: IJPR

Afshin Vahabzadeh, Hossein Vatanpour, Rasoul Dinarvand, Ali Rajabzadeh, Jamshid Salamzadeh, Mehdi Mohammadzadeh
The influence of company reputation or what is often referred to as corporate reputation on branding strategy and producing intangible asset for different industries has been researched in western countries, but there is a gap for the generalizability of findings to countries out of the United State and Europe. To establish the western researcher's external validity of theories in other countries and to obtain a better understanding of the influences of branding and company reputation on pharmaceutical business markets, the researchers applied this study for Iran, a country in the Middle East...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Majid Annabi, Abbas Kebriaeezadeh, Timor Mohammadi, Seyed Nasrolah Marashi Shoshtari, Farid Abedin Dorkoosh, Abolghasem Pourreza, Hassan Heydari
The aim of this study was to measure the potential of production and the capacity used in the pharmaceutical industry. Capacity use is the actual production rate to the potential output, which reflects the gap between actual production and production capacity . Through econometric methods, translog cost function in the short run along with functions of share cost of production factors is estimated through seemingly unrelated repeated regression (SURE) as a multivariate regression analysis provided by zeller...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Negar Mortazavi, Hossein Esmaeilzadeh, Mohammad Abbasinazari, Delara Babaie, Soheila Alyasin, Hesamodin Nabavizadeh, Elmira Esmailzadeh
This study aimed to investigate the efficacy and the underlining mechanism of aspirin desensitization among patients with Aspirin Exacerbated Respiratory Disease (AERD). Thirty-eight patients, who had undergone an aspirin challenge test and were diagnosed as having AERD, were engaged in a double-blind randomized clinical trial. They were divided into two groups-an active group of patients who went through aspirin desensitization, and the control group, receiving placebo. Clinical symptoms and the quality of life of the patients-in addition to the levels of interleukin 4 and 5 (IL4), (IL5)-were documented at the beginning of the study and again after six months of aspirin desensitization...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Atieh Modarresi, Shadi Ziaie, Jamshid Salamzadeh, Zahra Sahraei, Mohsen Nafar, Yunes Panahi, Mahmoud Parvin, Behzad Einollahi
N-acetylcysteine (NAC) is a potent antioxidant that acts through regenerating glutathione stores and scavenging oxygen-free radicals. This study assesses the short-term effects of NAC in cadaveric kidney transplant (KT) recipients. A double blind, randomized, placebo controlled trial was designed and patients were randomly assigned to receive either NAC or placebo. Glutathione peroxidase (GPX) activity in erythrocytes and serum malondialdehyde (MDA) levels were measured and serum creatinine levels and estimated glomerular filtration rate (eGFR) determined in the early phase after transplantation, were also compared between two study groups...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Maryam Khoubnasabjafari, Khalil Ansarin, Vahid Jouyban-Gharamaleki, Vahid Panahi-Azar, Samin Hamidi, Zhila Azarmir, Abolghasem Jouyban
Drug abuse is a serious problem causing health, economical and psycho-social negative outcomes. Methadone is commonly used drug for management of drug addiction. Exhaled breath condensate (EBC) is a promising non-invasive biological sample which attracted more attention in recent years. This work aimed to extend the applicability of a developed preconcentration - liquid chromatographic method for analysis of methadone in serum and urine samples. Drug concentrations in EBC, serum and urine are also investigated for dose-concentration and their inter-correlations...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Ossama Mansour, Rawaa Al-Kayali
Antibiotic resistance is a major public health concern. This study was conducted to evaluate the knowledge, attitudes of community pharmacists regarding antibiotic use and potential drug resistance besides assessing their behaviors about dispensing antibiotic without prescription and correlation of the outcomes with demographic variables. A cross-sectional survey was conducted on a random sample of 250 pharmacies in Aleppo, using validated self-administered questionnaire. The total scores of the pharmacists' knowledge and attitudes were correlated with participant demographics using Chi-squared test...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Esmat Kamali Dolatabadi, Mohammadreza Ostadali Dehaghi, Naser Amirizadeh, Kazem Parivar, Reza Mahdian
Aberrant DNA methylation has been reported as an important phenotype in acute myeloid leukemia. However the clinical significance of methylation changes has not been clear yet. In this study methylation Specific Melting Curve Analysis (MS-MCA) and real time PCR was used to assess the CDKN2B promoter hyper-methylation and gene expression in 59 Iranian acute myeloid leukemia (AML) patients. The incidence of aberrant hyper methylation of CDKN2B gene and cytogenetic abnormalities were 37.3% (22 of 59 patients) and 35...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Liu Wei-Hong, Zhang Cheng-Gui, Gao Peng-Fei, Liu Heng, Yang Jian-Fang
Previous studies have reported inconsistent findings regarding the efficacy of omega-3 fatty acids on pregnant women with major depressive disorder (MDD). This meta-analysis was conducted to systematically evaluate the clinical applicability of omega-3 fatty acids in treating depression in pregnant women. Randomized controlled trials (RCTs) that compared omega-3 fatty acids to placebo for short-course treatment of depression in pregnant women were systematically reviewed between March 1999 and April 2015. The search terms used were 'depression', 'omega-3 fatty acids', 'fish oil', 'eicosapentaenoic acid' and 'docosahexaenoic acid'...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Mojtaba Mojtahedzadeh, Farhad Etezadi, Gholamreza Pourmand, Amir Hossein Najafi Abrandabadi, Javad Motaharinia
Ischemia reperfusion injury (IRI) is one of the main causes of delayed graft function (DGF) in deceased-donor kidney transplantation (DDKT). Evidences suggest that hypertonic saline (HS) has beneficial effects on IRI. The objective of the present study is to determine the effect of intraoperative HS, on graft function and urinary biomarkers of interleukin 18 (IL-18) and neutrophil gelatinase-associated lipocalin (NGAL), in patients with DDKT. The design of the study is a randomized, open-label, pilot trial in patients with DDKT...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Sally Aly Helmy, Mona Ibrahim El-Assal
Co-administration of norfloxacin (NFX) and tinidazole (TNZ) has been used for the treatment of gastrointestinal and urinary tract infections. Concomitant oral administration of NFX with TNZ may affect NFX absorption and consequently its blood concentration and pharmacological effect. The present study was undertaken to investigate the effect of TNZ at the usual clinical dosage on the pharmacokinetics of NFX in healthy volunteers. This study was conducted as an open-label, randomized, two-way crossover experimental design...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Zeinab Sharafi, Mahmood Barati, Mohammad Reza Khoshayand, Sina Adrangi
Among the two types of bacterial L-asparaginases, only type II enzymes have been used in the treatment of acute lymphoblastic leukemia owing to their higher affinity for L-asparagine. However, current screening media used for the isolation of L-asparaginase-producing microorganisms do not discriminate between the two types of L-asparaginase. During an optimization study conducted to increase L-asparaginase production by environmental Halomonas isolates, it was noticed that the pattern of L-asparaginase production in response to variations in glucose concentration varied between different isolates suggesting that they differ in their ability to produce type II L-asparaginases, an observation that was confirmed by further experiments...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Saeed Azadi, Arash Mahboubi, Nasser Naghdi, Roya Solaimanian, Seyyed Alireza Mortazavi
Recombinant protein production in Pichia pastoris is based on alcohol oxidase promoters which are regulated by methanol. However, the use of methanol has several disadvantages, which is why current trends in bioprocess development with Pichia pastoris (P. pastoris ) are focusing on methanol mixed feeding strategies. This work aimed to develop a new experimental method and compare the effect of various fractions of sorbitol in mixed feeding strategy with stepwise addition of methanol to maximize the productivity of human growth hormone...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Morteza Mohajeri Amiri, Mohammad Reza Fazeli, Mohsen Amini, Nasim Hayati Roodbari, Nasrin Samadi
Designing enriched probiotic supplements may have some advantages including protection of probiotic microorganism from oxidative destruction, improving enzyme activity of the gastrointestinal tract, and probably increasing half-life of micronutrient. In this study Saccharomyces cerevisiae enriched with dl-α-tocopherol was produced as an accumulator and transporter of a lipid soluble vitamin for the first time. By using one variable at the time screening studies, three independent variables were selected. Optimization of the level of dl-α-tocopherol entrapment in S...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Zeinab Faghfoori, Bahram Pourghassem Gargari, Amir Saber, Maryam Seyyedi, Ahmad Yari Khosroushahi
Nowadays, there is an increasing interest in the production of functional foods, particularly probiotic foods. Lactic acid bacteria (LAB) particularly strains of Lactobacillus are important bacteria in food microbiology and human nutrition due to their ability to fermented food production and have received considerable attention as probiotics. The traditional fermented dairy foods as a rich source of wild LAB can introduce new Lactobacillus strain with probiotic properties into food products. So, the present study was aimed to isolate and identify Lactobacilli spp ...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Fatma Njeh, Dhekra Mhalla, Ibtissem Ben Hammouda, Mohamed Trigui, Raoudha Mezghani-Jarraya
Hexane, ethyl acetate and methanol extracts of Onopordum espinae leaves were investigated for their antibacterial activities against Bacillus cereus , Staphylococcus aureus , Enterococcus faecalis , Escherichia coli , Pseudomonas aeruginosa, and Salmonella enteritidis . Hexane and ethyl acetate extracts were toxic to Gram-positive bacteria with inhibition zone diameters ranging between 12 and 30 mm. Two products, hispidulin 1 , and dehydromelitensin-8-(4ꞌ-hydroxy-methacrylate) 2 were isolated from the ethyl acetate extract of leaves and identified by 2D-NMR for the first time from this species...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Azadeh Hamedi, Gholamhossein Yousefi, Shirin Farjadian, Mitra Saadat Bour Bour, Elahenaz Parhizkar
Plants gums are complex mixtures of different polysaccharides with a variety of biological activities and pharmaceutical applications. Few studies have focused on physicochemical and biological properties of gums obtained from different plants. This study was designed to determine potential pharmaceutical and pharmacological values of the gum exudates and its isolated biopolymers obtained from Astragalus myriacanthus Boiss [syn. Astracantha myriacantha (Boiss.) Podlech] (Fabaceae). The physicochemical, rheological, and mucoadhesion properties of the gum and its fractions was measured at 7, 27, and 37 °C with and without the presence of NaCl (1%)...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Mona Hafez Hetta, Abeer Sayed Moawad, Manal Abdel-Aziz Hamed, Ahmed Ismail Sabri
This study was designed in order to correlate the flavonoid and lipoidal matters content of Spinach roots and flowers to their hypolipidemic potential. The total flavonoid content was measured via complexation with aluminum chloride while determination of fatty acids methyl esters and unsaponifiable matters in both organs was performed using GC/MS. In an in-vitro study, the crude ethanol extracts of both organs and their different fractions were separately examined for inhibition of β -hydroxy- β -methyl glutaryl coenzyme A reductase (HMG-CoA reductase); the rate limiting enzyme of cholesterol biosynthesis...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Tajmah Mombeini, Hamid Gholami Pourbadie, Mohammad Kamalinejad, Soroush Mazloumi, Ahmad Reza Dehpour
The present study was conducted to investigate the possible anxiolytic and sedative of an acute administration and 4-day repeated dosing of an aqueous extract of flowers of Alcea aucheri (Boiss.) Alef. (EFA)in rats subjected to the elevated plus-maze (EPM), open-field, and horizontal wire tests. All drugs were administered intraperitoneally. Phytochemical screening confirmed the presence of phenolic compounds, flavonoids, and polysaccharides in the extract. Repeated dosing of EFA (at dose of 35 mg/kg) significantly increased percentage of time spent on open arms and of open arms entries, and also decreased percentage of time spent on closed arms and of closed arms entries; compared with saline control, 24 h after treatment...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Eisa Tahmasbpour, Mostafa Ghanei, Yunes Panahi
Sulfur mustard (SM) is a strong alkylating and mutagenic compound that targets human airway system. We considered the expression of Forkhead box M1 ( FOXM1 ) and apolipoprotein E ( APOE ) genes, which are responsible for cell proliferation, differentiation, tumorigenesis, and increased risk of lung cancer, in the lung bronchial tissue of patients exposed to SM. After performing pulmonary functional tests (PFTs), 11 human subjects (five controls and six SM-exposed patients) were entered in this study. Total RNA were extracted from all biopsy samples and then cDNA was synthesised for each specimen using RT-PCR...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Fatemeh Mohammadpour, Seyed Nasser Ostad, Shima Aliebrahimi, Zahra Daman
Studies show that cancer cell invasion or metastasis is the primary cause of death in malignancies including breast cancer. The existence of cancer stem cells (CSCs) in breast cancer may account for tumor initiation, progression, and metastasis. Recent studies have reported different effects of cannabinoids on cancer cells via CB1 and CB2 cannabinoid receptors. In the present study, the effects of ACEA (a selective CB1 receptor agonist) and AM251 (a selective CB1 antagonist) on CSCs and their parental cells were investigated...
2017: Iranian Journal of Pharmaceutical Research: IJPR
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