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Iranian Journal of Pharmaceutical Research: IJPR

Xiang-Lin Yang, Yuan Zhou, Xin-Ling Liu
A series of structurally related 2,4-dioxopyrimidine-1-carboxamide derivatives as highly potent inhibitors against acid ceramidase were subjected to hologram quantitative structure-activity relationship (HQSAR) analysis. A training set containing 24 compounds served to establish the HQSAR model. The best HQSAR model was generated using atoms, bond, connectivity, donor and acceptor as fragment distinction and 3-6 as fragment size with six components showing cross-validated q(2) value of 0.834 and conventional r(2) value of 0...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Seyed Hossein Davoodi, Roghiyeh Shahbazi, Saeideh Esmaeili, Sara Sohrabvandi, AmirMohamamd Mortazavian, Sahar Jazayeri, Aghdas Taslimi
Milk is an important component of a balanced diet and contains numerous valuable constituents. Considerable acclaimed health benefits of milk are related to its proteins, not only for their nutritive value but also for their biological properties. Scientific evidence suggests that anticarcinogenic activities, antihypertensive properties, immune system modulation, and other metabolic features of milk, are affiliated with its proteins (intact proteins or its derivatives). In this article, the main health-related aspects of milk proteins, such as anticarcinogenic, immunomodulatory, antimicrobial, anticariogenic, antihypertensive, and hypocholesterolemic effects are reviewed...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Golbarg Ghiasi, Arash Rashidian, Abbas Kebriaeezadeh, Jamshid Salamzadeh
The impact of the international sanctions on the Central Bank of Iran in 2013 and also accessibility of medicines in this country have received a lot of media coverage. In this study we used the data collected from a group of pharmacies all located in Tehran to assess the potential effects of the banking sanctions on access to asthma medicines. Data were collected from forty community pharmacies in Tehran, using a standard methodology proposed by the WHO and Health Action International. Data were collected in two stages: first before the sanctions were made against the banking system in the summer of 2012, and second after they were in effect in the summer of 2013, and they were analyzed using univariate analysis techniques...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Maryam Majidinia, Yousef Rasmi, Mohammad Hassan Khadem Ansari, MirHossein Seyed-Mohammadzad, Ehsan Saboory, Alireza Shirpoor
Endothelial dysfunction which is manifested by the loss of nitric oxide bioavailability, is an increasingly recognized cause of cardiac syndrome X (CSX) and beta blockers are used for the treatment of this syndrome. Thus, the aim of this study was to investigate effects of metoprolol, as a beta blocker, on endothelial function in CSX patients. The study included 25 CSX patients (20 female/ 5 male, mean age: 55.36±10.31 years) who received metoprolol (50 mg BID) for one month. In addition, 25 healthy controls (20 female/ 5 male, mean age: 54...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mehrnoosh Shanaki, Arash Hossein-Nezhad, Reza Meshkani, Maani Beigy, Mahmoud Shirzad, Parvin Pasalar, Taghi Golmohammadi
Coronary artery disease (CAD) is the major cause of mortality and morbidity worldwide. The aim of this study was to explore the effect of resveratrol (RES) on Canonical β-catenin/Wnt and forkhead box O (FOXO) pathways in CAD patients. We performed this study on 10 metabolic syndrome patients with three-vessel CAD and 10 sex-aged matched healthy subjects. The effects of RES on β-Catenin, manganese superoxide dismutase (MnSOD), and peroxisome proliferator-activated receptor delta (PPAR-δ) expression were evaluated in peripheral blood mononuclear cells (PBMCs) of participants...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Shahnaz Bahadori, Jamshid Salamzadeh, Mohammad Kamalinejad, Mohammad Reza Shams Ardekani, Mansoor Keshavarz, Arman Ahmadzadeh
This study was designed to explore the complementary effects of a combination formulation of olive oil, olive and fig fruits on RA remission indicators. A randomized controlled clinical trial was designed. Adult RA patients were randomly divided into two groups receiving routine Disease-modifying antirheumatic drugs (DMARDs) regimen (control group) and routine DMARDs regimen plus the herbal supplementary formulation of olive oil, fig and olive fruits (intervention group). Patients were followed every 4 weeks for total study period of 16 weeks...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Eman Shawky
Amaryllidaceae is a well-known family for its high alkaloidal content. These alkaloids comprise a unique group of bases that have been found to occur in this family. The Amaryllidaceae alkaloids represent a large and still expanding group of isoquinoline alkaloids, the majority of which are not known to occur in any other family of plants. This article reports on the phytochemical investigation of the alkaloidal content of the flowers of clivia nobilis cultivated in Egypt which resulted in the isolation of four alkaloids; lycorine with pyrrolo{de}phenanthridine nucleus (lycorine-type) which is the common alkaloid of the amaryllidaceae family, clivatine and nobilisine, both with [2]benzopyrano (3,4-g) indole nucleus (lycorenine-type) and (+) 8-O-demethylmaritidine with 5,10b-ethanophenanthridine nucleus (crinine-type)...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Solmaz Asnaashari, Fariba Heshmati Afshar, Sedigheh Bamdad Moghadam, Abbas Delazar
Six extracts with different polarity from aerial parts and rhizomes of Eremostachys azerbaijanica Rech.f., were screened for their antimalarial properties by cell free
2016: Iranian Journal of Pharmaceutical Research: IJPR
Seyed Ebrahim Sajjadi, Nader Pestechian, Mahnaz Kazemi, Mohammad-Ali Mohaghegh, Ahmad Hosseini-Safa
Resistance to most antimalarial drugs has encouraged the development of novel drugs. An alternative source for discovering such drugs is natural products. Some Ferulago species are used in folk medicine for their sedative, tonic and anti-parasitic effects. Besides, coumarins isolated from this genus found to have in vitro anti-leishmanicidal effect. The present study is aimed to evaluate the in-vivo antimalarial activity of Ferulago angulata (Schlecht.) Boiss. extract and suberosin epoxide, using suarian mice...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Narayan Dolai, Aminul Islam, Pallab Kanti Haldar
The purpose of this investigation was to evaluate the antiproliferative and apoptogenic mechanistic studies of methanol extract of Anthocephalus cadamba (MEAC) on Dalton's lymphoma ascites (DLA) cells treated mice. Determination of antiproliferative activity was performed by using different DLA cells (2×10(6) cells, i.p.) inoculated mice groups (n = 12). Groups were treated for 14 consecutive days with MEAC at the doses of 200 and 400 mg/Kg b.w. respectively. The mechanism of antiproliferation activity of MEAC was investigated through morphological studies by acridine orange (AO)/ethidium bromide (EB) double staining method...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Bakar Filiz, Karakay Songül, Delimustafaoğlu Bostanlık, Fatma Gül, Kılıç Ceyda Sibel
Ferulago W. Koch. (Apiaceae) genus is represented by approximately 50 taxa throughout the world. Ferulago species are known as "Çakşır" or "Çağşır" in Turkey and mostly known for their aphrodisiac effects. However recent reports emphasize the activity of various Ferulago species against cancer, as well. The aim of this study was to investigate the effect of lyophilized extract of F. mughlea Peşmen, a species endemic for Turkey, on cancer cell proliferation. For this purpose human prostate (PC-3) and colorectal (SW-480) carcinoma cells were used to evaluate the antiproliferative effects of Ferulago W...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Amir Amniattalab, Hassan Malekinejad, Aysa Rezabakhsh, Shirin Rokhsartalab-Azar, Shahin Alizade-Fanalou
This study aimed to investigate the potency of silymarin (SMN) and melatonin (MEL) on restoring the pancreatic   cells in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were divided into five groups, including: control (C), untreated diabetic (D), SMN-treated diabetic (50 mg/Kg, orally), MEL-treated diabetic (10 mg/Kg, i.p.), and SMN plus MEL-treated diabetic rats. Diabetes was induced by injection of STZ (50 mg/Kg, i.p.). The blood glucose and insulin levels were measured. After the 28 days treatment period, antioxidant status was analyzed by determination of total antioxidant capacity (TAC) in the liver and serum...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Saly F Gheda, Hala I El-Adawi, Nehal M El-Deeb
Hepatitis C virus (HCV) has infected 3% of the population worldwide and 20% of the population in Egypt. HCV infection can lead to hepatocellular carcinoma and death. The presently available treatment with interferon plus ribavirin, has limited benefits due to adverse side effects. Seaweeds have become a major source of new compounds to treat viral diseases. This work aimed to study the effect of four species of seaweeds as anti- HCV. The inhibition of lipid peroxidation was measured by evaluating the ability of seaweed extracts to scavenge the free radicals...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mahboubeh Taherkhani
The aim of this study was to determine the chemical constituents, antimicrobial, cytotoxicity, mutagenic and anti-mutagenic activities of the essential oil of Artemisia ciniformis Krasch. & Popov ex Poljakov, against important bacterial pathogens and human cells which were unknown before. In-vitro cytotoxicity was measured using a modified MTT assay on normal human lymphocytes and tumor HeLa cells. The mutagenic and antimutagenic activities of the oil were evaluated using the Salmonellatyphimurium tester strains TA98 and TA100, together with nitrofluorene for TA98 and sodium azide for TA100 without (-S9) metabolic activation, and 2-aminoantracene for TA98 and TA100 with metabolic (+S9) activation...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Jamal Shamsara, Ahmad Shahir-Sadr
Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationships) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with reported biological activity against COX-2 were used to construct a predictive comparative molecular similarity indices (CoMSIA) model...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Qiu-Hong Zhao, Zhong-Duo Yang, Zong-Mei Shu, Yong-Gang Wang, Ming-Gang Wang
In the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from Talaromyces sp. LGT-2, an endophytic fungus from Tripterygium wilfordi. Their structures were determined based on NMR and ESI-MS spectral data, as well as comparing previous literature data. This is the first report of the isolation of alkaloids (1-9) from Talaromyces genus. In the next step, all compounds were screened for their anti-monoamine oxidase, anti-acetylcholinesterase, antibacterial and antitumor activities...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Maryam Azimi, Nastaran Nafissi-Varcheh, Mohammad Ali Faramarzi, Reza Aboofazeli
The aim of this study was to develop a microemulsion system as a medium for laccase-catalyzed reactions. Phase behavior studies were conducted by constructing partial pseudo-ternary phase diagrams for systems comprising of cetyltrimethylammonium bromide (CTAB), various organic solvents as the oil phase (i.e., hexane, cyclohexane, heptane, octane, isooctane, toluene, isopropyl myristate), two co-surfactants (i.e., 1-butanol and 1-hexanol) and citrate buffer solution, at various surfactant/co-surfactant weight ratios (Rsm)...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mahmood Barati, Mohammad Ali Faramarzi, Nastaran Nafissi-Varcheh, Mohammad Reza Khoshayand, Mohammad Hassan Houshdar Tehrani, Hossein Vahidi, Sina Adrangi
The objective of this study was to isolate halophilic bacteria with the ability to produce intracellular or extracellular L-asparaginase. A total number of 120 halophilic bacteria were isolated from 17 different saline habitats of Iran including salt lakes, wetlands, brine springs and deserts. Among these, 68 were able to grow in the presence of 1.5 M NaCl and 52 demonstrated the ability to grow in the selection medium containing 3.5 M NaCl. None of the isolates appeared to produce appreciable amounts of extracellular L-asparaginase...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mahdi Mashhadi Akbar Boojar, Mahsa Hassanipour, Shahram Ejtemaei Mehr, Masoud Mashhadi Akbar Boojar, Ahmad Reza Dehpour
Ceramide as a second messenger is a key regulator in apoptosis and cytotoxicity. Ceramide-metabolizing enzymes are ideal target in cancer chemo-preventive studies. Neutral sphingomyelinase (NSMase), acid ceramidase (ACDase) and glucosyl ceramide synthase (GCS) are the main enzymes in ceramide metabolism. Silymarin flavonolignans are potent apoptosis inducers and silibinin is the most active component of silymarin. This study evaluated the effects of silybin A, silybin B and their 3-O-gallyl derivatives (SGA and SGB) at different concentrations (0-200 micro molar) on ceramide metabolism enzymes in Hep G2 hepatocarcinoma cell line...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Nima Razzaghi-Asl, Ramin Miri, Omidreza Firuzi
Cancer is a leading cause of death worldwide. Despite the availability of several chemotherapeutic drugs, there is still a great need for more efficient agents for a better management of cancer. In this contribution, a series of 11 1,4-dihydropyridines (1,4-DHPs) (4a, 4b and 7a-i) were synthesized and evaluated for their cytotoxic effect against MCF-7, LS180 and MOLT-4 cancer cell lines using MTT assay. Synthesized 2,6-dimethyl-3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridines exhibited different potencies ranging from weak to good cytotoxic activities, while no activity could be recorded for 1,4-bis(2,6-dimethyl-3,5-dialkyloxylcarbonyl,4-dihydropyridine-4-yl) benzene compounds (4a and 4b)...
2016: Iranian Journal of Pharmaceutical Research: IJPR
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