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Iranian Journal of Pharmaceutical Research: IJPR

Reza Masaeli, Tahereh S Jafarzadeh Kashi, Rassoul Dinarvand, Mohammadreza Tahriri, Vahid Rakhshan, Mehdi Esfandyari-Manesh
Microspheres formulated from poly (D, L-lactic-co-glycolide) (PLGA), a biodegradable polymer, have been extensively evaluated as a drug delivery system. In this study, the preparation, characterization and drug release properties of the PLGA microspheres were evaluated. Simvastatin (SIM)-loaded PLGA microspheres were prepared by oil-in-water emulsion/solvent evaporation method. The microspheres were then frozen to -80 °C, they were freeze dried for 24 h. Characterization of SIM-loaded PLGA microspheres was evaluated by X-ray diffraction analysis, Fourier transform infrared spectroscopy analysis, and scanning electron microscopy (SEM)...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Hirsa Mostafapour Kandelous, Misha Salimi, Vahid Khori, Noushin Rastkari, Amir Amanzadeh, Mona Salimi
Chamaemelum nobile (Asteraceae) commonly known as 'Roman chamomile' is a medicinal plant used for numerous diseases in traditional medicine, although its anticancer activity is unknown. The present study was carried out to investigate the anticancer as well as apoptotic activity of ethyl acetate fraction of C. nobile on different cancerous cell lines. The cells were treated with varying concentrations (0.001- 0.25 mg/mL) of this fraction for 24, 48 and 72 h. Apoptosis induced in MCF-7 cells following treatment with ethyl acetate fraction was measured using Annexin V/PI, flowcytometry and western blotting analysis...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mehrdad Faizi, Enayatollah Seydi, Sadegh Abarghuyi, Ahmad Salimi, Sanaz Nasoohi, Jalal Pourahmad
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects regions of the brain that control cognition, memory, language, speech and awareness to one's physical surroundings. The pathological initiation and progression of AD is highly complex and its prevalence is on the rise. In his study, Alzheimer's disease was induced with single injection of amyloid-β (Aβ) peptides (30ng, by stereotaxy) in each hemisphere of the Wistar rat brain. Then memory dysfunction, oxidative stress and apoptosis induced by Aβ peptide were investigated on isolated brain mitochondria obtained from infected rat...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mona Zamanian-Azodi, Mostafa Rezaei-Tavirani, Sara Rahmati-Rad, Majid Rezaei Tavirani
Ethanol has a vast consumption around the world. Many researches confirmed some adverse effect of this component on human health. In addition, recent studies showed significant alteration in both cellular population, and protein profile of human foreskin fibroblast cell line (HFFF2) in the specific dosage of ethanol. Here, the role and interaction of some proteins (characterized by significant alteration in expression due to ethanol effect) analyzed by proteomics and evaluated by considering cancerous case...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Samira Eslamizad, Farzad Kobarfard, Katayon Javidnia, Ramezan Sadeghi, Mitra Bayat, Sara Shahanipour, Najmeh Khalighian, Hassan Yazdanpanah
A fast and simple modified QuEChERS extraction method was developed for determination of Benzo[a]pyrene (BaP) in 137 traditional (Sangak), semi-industrial (Sangak) and industrial bread samples using spiked calibration curves by GC/MS. Sample preparation includes extraction of BaP into acetone followed by cleanup with dispersive solid phase extraction. The limit of detection and limit of quantification were 0.3 ng/g and 0.5 ng/g, respectively. The values for recoveries and RSD were calculated as 110.5-119.85% and <11...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mahdi Tabarraee, Maria Tavakoli-Ardakani, Mahshid Mehdizadeh, Mojtaba Ghadiani, Hamid Rezvani, Abbas Hajifathali, Samiyeh Khamsi
Antibiotic prophylaxis is usually used in allogeneic stem cell transplantation, but its use in Autologous Stem Cell Transplantation (ASCT) is controversial. We evaluated the efficacy of ciprofloxacin prophylaxis in ASCT. To identify the efficacy of ciprofloxacin on the incidence of neutropenic fever and its complications, 72 patients that had been admitted to Taleghani Hospital for ASCT between 2010 and 2012 were evaluated in our study. Oral ciprofloxacin 500 mg every 12 h was administered to 30 patients on the same day of high dose chemotherapy until the first febrile episode or until the recovery of neutropenia and the results were analyzed and compared with the historical control group 42 other transplanted patients who had not previously received ciprofloxacin...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Maryam Jahandideh, Homa Hajimehdipoor, Seyed Alireza Mortazavi, Ahmadreza Dehpour, Gholamreza Hassanzadeh
Herbal therapy was the common treatment prescribed by Iranian physicians for wound healing. "Zemad" was the most ancient pharmaceutical dosage form used in Iranian Traditional Medicine (ITM) for skin diseases. In the present research, formulation of a traditionally used Poly Herbal Paste (PHP) for wound healing was performed. Moreover, the fingerprint of the product was prepared by HPTLC method for identification and quality assessment of the formulation. 3.33 % of each plant materials containing Aloe vera, Boswellia carteri and Commiphora myrrha were used in a hydrophilic base...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Ehsan Fattahian, Valiollah Hajhashemi, Mohammad Rabbani, Mohsen Minaiyan, Parvin Mahzouni
Depressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antidepressants such as amitriptyline has been reported. Acetic acid colitis was induced in both reserpinised (depressed) and non-reserpinised (normal) rats. Reserpinised groups received reserpine (6 mg/kg, i.p.) one hour prior to colitis induction. Then Amitriptyline (5, 10, 20 mg/kg, i.p.) was administered to separate groups of male Wistar rats. All treatments were carried out two hours after colitis induction and continued daily for four days...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mehdi Teimouri, Farshad Farzadfar, Mahsa Soudi Alamdari, Amir Hashemi-Meshkini, Parisa Adibi Alamdari, Ehsan Rezaei-Darzi, Mehdi Varmaghani, Aysan Zeynalabedini
Data about the prevalence of communicable and non-communicable diseases, as one of the most important categories of epidemiological data, is used for interpreting health status of communities. This study aims to calculate the prevalence of outpatient diseases through the characterization of outpatient prescriptions. The data used in this study is collected from 1412 prescriptions for various types of diseases from which we have focused on the identification of ten diseases. In this study, data mining tools are used to identify diseases for which prescriptions are written...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Karim Ebrahim, Hossein Vatanpour, Abbas Zare, Farshad H Shirazi, Mryam Nakhjavani
Cancer is the leading cause of death worldwide. Current anticancer drugs involve various toxic side effects; efforts are ongoing to develop new anticancer agents especially from the screening of natural compounds. Present study investigated cytotoxic effects and mode of cell death induced by the Caspian cobra venom in some human cancer cell lines. Cytotoxic effects of snake venom toxins (SVT) were investigated via monitoring of morphological changes, MTT, trypan blue exclusion and LDH release assays. Mechanism of cell death was determined by AO/EtBr double staining, caspase-3 activity assay, flow cytometric analysis of apoptosis and mitochondrial membrane potential measurement...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Seyyed Ali Mard, Seyyed Mojib Azad, Akram Ahangarpoor
The present study aimed to evaluate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rats. Forty male rats were randomly divided into sham, control (I/R injury) and three crocin-pretreated groups. To induce I/R lesions, the celiac artery was clamped for 30 min and then the clamp was removed to allow reperfusion for 3 h. Pretreated-rats received crocin (7.5, 15 or 30 mg/kg, i.p.) 30 min prior to the induction of I/R injury. Samples of gastric mucosa were collected to measure the following variables: 1 mRNA expression of superoxide dismutase (SOD) and glutathione peroxidase (Gpx) by RT-PCR; 2 activity of superoxide dismutase and glutathione peroxidase and 3 tissue levels of malonyldehaldehyde (MDA)...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Leila Safaeian, Valiollah Hajhashemi, Shaghayegh Haghjoo Javanmard, Hamed Sanaye Naderi
Oxidative stress is one of the important mechanisms involved in Dexamethasone (Dex)-induced hypertension. Protocatechuic acid (PCA) is a natural compound with high antioxidant capacity. In this investigation, the effect of pretreatment with PCA was studied in Dex-induced hypertensive male Wistar rats. For induction of hypertension, Dex was injected subcutaneously for 14 days. PCA (50, 100 and 200 mg/kg) was started from 4 days before Dex administration and continued during the test period. Systolic blood pressure (SBP) was recorded using tail-cuff method...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Fatemeh Samiei, Akram Jamshidzadeh, Ali Noorafshan, Amir Ghaderi
Amiodarone is used in treatment of cardiac arrhythmias. Therapeutic use of amiodarone is limited by its side effects, including pulmonary toxicity. Human Placenta Extract (HPE) contains a variety of bio-active substances. Thus, the present study aimed to quantitatively evaluate the protective effects of HPE on the structural lung changes induced by amiodarone using stereological methods. Sprague-Dawley male rats were divided into four groups. The first, second, and third groups received no treatment, amiodarone (100 mg/kg, i...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Fatma Demirkaya-Miloglu, Tuba Oznuluer, Buket Ozdurak, Elmas Miloglu
Isoniazid (INH) was studied with regard to its electrochemical treatment on a strongly alkaline solution of a poly (3,4-ethylenedioxythiophene)-modified gold electrode, using both cyclic voltammetric and controlled potential techniques. Electrocatalytic performance measurements of this composite electrode toward oxidation of INH exhibited an increase of 4-folds in oxidation peak densities compared to the bare gold electrode. Central composite design method was used to obtain optimum experimental conditions, and used critical parameters (pH (A), scan rate (mV/s, B) and temperature (C, C) to assess the effects on amperometric response...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Ghodsi Mohammadi Ziarani, Shima Asadi, Alireza Badiei, Amirhossein Sharifi, Massoud Amanlou
New series of spiro indeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3'-indolines as new urease inhibitors were synthesized by the catalytic procedure in high yield and short reaction time. In this method, biacidic carbon was prepared as a novel heterogeneous acid and was subsequently used as an efficient catalyst. The inhibitory activities of synthesized compounds were tested against Jack bean urease using Berthelot colorimetric assay and docking simulation using AutoDock 4.2. The compound 4a with IC50 =1.94 µM has the most inhibitor activity in this study...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mohamed Mohamed Soliman, Mohamed Abdo Nassan, Tamer Ahmed Ismail
The present study was conducted to test the effect of Origanum MajoranumExtract (OME) of leaves on alterations induced in a model of type 2 diabetic rats. Adult male Wistar rats were fed high fat diet for 3 weeks and injected a single dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetic rats. Diabetic rats were given aqueous extract of OME in a dose of 20 mg/kg orally for 3 weeks. Changes in lipid profiles, glucose, insulin, expression of some genes related to glucose metabolism and histopathological changes in liver and kidney were examined...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mutiu Idowu Kazeem, Ayuva Mercy Mayaki, Bimpe Folashade Ogungbe, Anthony Babajide Ojekale
The side effects associated with the usage of synthetic antidiabetic drugs make it imperative to search for alternative drugs from medicinal plants. Therefore, this study was aimed at evaluating the α-amylase and α-glucosidase inhibitory potential of Calotropis procera leaf, as well as its possible mode of inhibiting these enzymes. Acetone, aqueous and ethanolic extracts of C. procera leaf was subjected to standard enzymes' inhibitory assay in-vitro using porcine pancreatic α-amylase and rat intestinal α-glucosidase...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Elham Hariri, Arash Mahboubi, Mohammad Fathi, Parisa Rahmani, Kamaleddin Haj Mohammad Ebrahim Tehrani, Mohammad Babaeian, Vida Mashayekhi, Farzad Kobarfard
A series of hydroxyl semicarbazone derivatives of substituted diaryl ketones and acetophenones were synthesized and their structures were confirmed by analytical and spectroscopic methods including elemental analysis, infrared and nuclear magnetic resonance spectroscopy. The derivatives were prepared by a condensation reaction between N-hydroxy semicarbazide and substituted diaryl ketones or acetophenones leading to the desired hydroxysemicarbazones with excellent purity. The synthesized hydrazones were then evaluated for their inhibitory activity against bacterial strains including S...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Abdul Majid Ayatollahi, Seyed Mohammad Zarei, Arash Memarnejadian, Mustafa Ghanadian, Mohammad Heydarian Moghadam, Farzad Kobarfard
Phytochemical investigation of the aerial parts of Euphorbia erythradenia Bioss. (Euphorbiaceae), one of Iranian endemic Euphorbias, with particular attention to triterpene constituents, using methanol solvent extraction was carried out. Five known triterpenes, including four cycloartanes and oleanolic acid, were isolated for the first time and identified using NMR and Mass techniques. Anti HIV activity of the isolated triterpenes and ingenoid diterpenes was evaluated using single cycle replicable HIV-1 (SCR HIV-1) virions...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mostafa Saffari, Hamid Reza Moghimi, Crispin R Dass
Gene therapy is a therapeutic approach to deliver genetic material into cells to alter their function in entire organism. One promising form of gene delivery system (DDS) is liposomes. The success of liposome-mediated gene delivery is a multifactorial issue and well-designed liposomal systems might lead to optimized gene transfection particularly in vivo. Liposomal gene delivery systems face different barriers from their site of application to their target, which is inside the cells. These barriers include presystemic obstacles (epithelial barriers), systemic barriers in blood circulation and cellular barriers...
2016: Iranian Journal of Pharmaceutical Research: IJPR
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