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Iranian Journal of Pharmaceutical Research: IJPR

Shahram Darabi, Ali Noori-Zadeh, Hojjat Allah Abbaszadeh, Farzad Rajaei
Bone marrow stromal stem cells (BMSCs) play a significant role in cell therapy. These cells quickly die after transplantation to the affected area due to oxidative stress. The natural disaccharide, trehalose which can be known as autophagy inducer. The present study aimed to investigate the role of trehalose in preventing BMSCs from oxidative stress caused by H2 O2 . BMSCs were isolated from the adult rats. The cells were divided into three groups: (a) control; (b) 100 µM H2 O2 ; (c) 100 µM H2 O2 and trehalose 3%...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Marziye Jafari, Shahram Ala, Kaveh Haddadi, Abbas Alipour, Mojtaba Mojtahedzadeh, Saeid Ehteshami, Saeid Abediankenari, Misagh Shafizad, Ebrahim Salehifar, Foroogh Khalili
Acute kidney injury (AKI) occurs both after traumatic brain injury (TBI) and after hypertonic saline administration; furosemide may be useful in preventing AKI indirectly. Serum neutrophil gelatinase-associated lipocalin (sNGAL) is superior to serum creatinine (sCr) in diagnosing early AKI. We compared the administration of hypertonic saline plus furosemide (HTS+F) versus hypertonic saline (HTS), using sCr and sNGAL to investigate kidney injury in patients with TBI. This randomized, single-blind clinical trial was conducted from August 2016 to July 2017 in a neurosurgical intensive care unit, and included patients with a Glasgow Coma Score (GCS) 7-13 and brain edema...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Farzaneh Dastan, Hamidreza Jamaati, Habib Emami, Rodabeh Haghgoo, Raha Eskandari, Seyedeh Shadab Hashemifard, Fatemeh Khoddami, Zahra Mirshafiei Langari
Albumin is known as a human blood product, with high cost and limited availability. Several studies have demonstrated the extent in which albumin is being utilized in controversial indications not supported or weakly supported by the available literature. To rationalize the use of albumin and to decrease the inappropriate cost of this expensive drug` a two phase study, with equal length of 66-days, comprising an observational drug utilization evaluation and a pharmacist-led audit and feedback interventional study, was conducted in a tertiary referral hospital in Tehran, Iran...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Mohsen Ebrahimi, Mohammad Javad Khoushnoud, Majid Zia-Behbahani
Certain organophosphorus esters, such as diisopropylfluorophosphate (DFP), cause delayed neuropathy by inhibition of neuropathy target esterase (NTE) keeping the neuron in normal function. In this study, effects of neurobion alone and in combination with dexamethasone on DFP-induced delayed neuropathy were evaluated. Thirty-five mice were divided into five groups, each consisting of 7 mice. Except group1 (Normal group), group 2 received normal saline and 1h later, 1 mg/kg DFP; groups 3, 4 and 5 received 150 mg/kg neurobion, 2 mg/kg dexamethasone and 150 mg/kg neurobion plus 2 mg/kg dexamethasone, respectively and 1h later 1mg/kg DFP...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Sayed Hesam Aldin Sharifnia, Mehdi Mohammadzadeh, Gelareh Arzani, Jamshid Salamzadeh, Sayed Abolfazl Abolfazli, Alireza Zali, Ali Reza Khoshdel
Prescription decision making is a complicated phenomenon influenced by many factors including drug strength, the patient's context, prescriber characteristics, health facilities, payment type, and pharmaceutical marketing. To evaluate the associations between each influenced factor and drug prescription method of Iranian physicians, we conducted an exploratory research, utilizing a questionnaire as quantitative research instrument. A sample of 460 physicians was asked to fill out the questionnaire, yielding 84% response rate...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Mohammad Haji Aghajani, Farzad Kobarfard, Seyed Pouzhia Shojaei, Froozan Ahmadpour, Olia Safi, Neda Kazemina, Naeime Zarepishe, Mohammad Sistanizad
The aim of current study was evaluating the frequency of clopidogrel resistance and its impact on clinical outcome of patients in Iranian patients. Patients undergoing percutaneous coronary intervention in Imam Hussein Medical center, Tehran, Iran, who received standard dosage of clopidogrel (Plavix®, Sanofi, France, 600 mg loading dose and 75 mg/day afterward) were recruited. Platelet aggregation was measured using light transmission aggregometer. The patients were categorized as responder (platelet aggregation less than 43%) and non-responder (platelet aggregation more than 43%)...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Mehrdad Afarid, Ali Sadegi Sarvestani, Feisal Rahat, Ali Azimi
Several ocular and systemic complications have been reported after the bevacizumab intravitreal injection. This study aims at reporting the main indications for the bevacizumab intravitreal injection in our center, the intravitreal injection method in this study, and the incidence of the post-injection complication, such as endophthalmitis.This study is a retrospective review of the consecutive intravitreal bevacizumab (Avastin®) injections for 359 patients between 2011 and 2013 at a single institute (Poostchi Clinic of Ophthalmology)...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Hamed Zare, Parviz Owlia, Hossein Vahidi, Maryam Hosseindokht Khujin
Selenium (Se) as a vital trace element has many biological activities such as anti-inflammation and anti-oxidation. Selenomethionine as an organic selenium plays a vital role in the response to oxidative stress. At present, Saccharomyces cerevisiae is one of the best microorganisms that has the ability to accumulate selenium. Production of Seleno-yeast was done by growing Saccharomyces cerevisiae in the presence of water soluble selenium salt (Na2 SeO3 ) as a part of the medium. The yield of selenium biotransformation and yeast biomass can be improved by optimizing the process conditions in two steps...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Mehdi Hassanpour, Omid Cheraghi, Belal Brazvan, Amirataollah Hiradfar, Nasser Aghamohammadzadeh, Reza Rahbarghazi, Mohammad Nouri
By virtue of lifestyle change, incidence of diabetes mellitus type 2 is increasingly being raised with different up-surging pathologies. It was showed that endothelial progenitor cells (EPCs) were disqualified in neo-angiogenesis induction. Besides, to an aborted differentiation property, malfunctioned paracrine activities worsen off vascular abnormality. Nano-scaled exosomes play essential roles in reciprocal cell-cell crosstalk via bioactive molecules. To address the effect of diabetic serum on exosome secretion capacity, EPCs were exposed to diabetic condition for seven days...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Arezou Azizsoltani, Khosro Piri, Sahar Behzad, Masoud Soleimani, Mina Nekouei, Zahra Mahmoudi, Asad Kazemi
Glycyrrhiza glabra (G. glabra) has been used as a flavoring and sweetener agent, in addition to its therapeutic properties. It is rich in phytoestrogen and may prevent osteoporosis caused by estrogen deficiency; however, there is no evidence for its effects on proliferation and osteogenesis in mesenchymal stem cells. So, we were encouraged to investigate whether the ethyl acetate extract of licorice root as a source of phytoestrogen can act similar to estrogen in cell culture. Furthermore, the analysis of the licorice extract (LE) based on HPLC-DAD-ESI-MS indicated that LE comprises phytoestrogen compounds, such as glabridin and glabrene...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Belma Zengin Kurt, Işıl Gazioğlu, Ece Sevgi, Fatih Sönmez
Turkey has highly rich floras of medicinal and aromatic plants because of having various climate conditions in different regions. One of these regions is Middle Black Sea Region, especially Ordu Province. Extracts of 10 edible plants ( Arum maculatum L., Hypericum orientale L., Ornithogalum sigmoideum Freyn et Sint., Silene vulgaris Garcke var. macrocarpa , Plantago lanceolata L., Achillea millefolium L. subsp. pannonica , Rumex crispus L., Rumex acetosella L., Capsella bursa-pastoris L., Coronopus squamatus Asch...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Esra Eroglu Ozkan, Nurten Ozsoy, Tugba Yilmaz Ozden, Gul Ozhan, Afife Mat
In the present work we carried out a phytochemical and biological investigation on three endemic Hypericum species, i.e. Hypericum thymbrifolium (H. thymbrifolium), Hypericum spectabile (H. spectabile) and Hypericum pseudolaeve (H. pseudolaeve) from Anatolia in order to discover new sources of natural compounds for the treatment of inflammatory and neurodegenerative disorders. HPLC-DAD analysis indicated that two naphthodianthrones (pseudohypericin and hypericin) together with chlorogenic acid, rutin, hyperoside, isoquercitrin, kaempferol, quercitrin, quercetin, amentoflavone, and hyperforin are the main compounds present in the methanol extracts...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Asmaa Abdella, Ashraf F El Baz, Emad Eldin Mahrous, Alaa A Abd El Maksoud, Ibrahim A Ibrahim, Azza R Abdel-Monem, Shang-Tian Yang
Biotransformation of isoflavones glycosides into the aglycone form is essential to attain the maximum bioavailability. The factors affecting deglycosylation of genistin in soy flour using commercial β -glucosidase enzyme were evaluated. The presence of genistin in soy flour was confirmed by isolation through chromatographic fractionation and identification by spectral method. Two-levels Plackett-Burman design was applied and effective variables for genistein production were determined. Agitation rate, enzyme concentration, and reaction time, owing to their significant positive effect, and pH, owing to its significant negative effect, were further evaluated using Box-Behnken model...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Bibi Marjan Razavi, Ali Alyasin, Hossein Hosseinzadeh, Mohsen Imenshahidi
Crocus sativus L. (saffron) is a widely used food additive for its color and taste. The hypotensive effects of saffron have been shown in previous studies. The aim of this study was to evaluate the mechanism of vasodilatory effects induced by saffron on isolated rat aorta. To study the vasodilatory effects of saffron aqueous extract (0.5, 1 and 2 mg/mL), isolated rat thoracic aorta rings were contracted by 10-6 M phenylephrine (PE) or KCl 80 mM. The vasodilatory effect of saffron was also evaluated both on intact and denuded endothelium aortic rings...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Maryam Fanian, Maedeh Bahmani, Mojdeh Mozafari, Samaneh Naderi, Marzieh Alizadeh Zareie, Mohammad Ali Okhovat, Jamileh Saberzadeh, Ali Dehshahri, Mohammad Ali Takhshid
Metastasis to lymph nodes and distant organs is the main challenge in the treatment of papillary thyroid cancer. In the current investigation, we aimed to evaluate the synergistic effects of celecoxib (CX) and sodium valproate (VPA) against cell survival, invasiveness properties, and expression of metalloproteinase-2 and -9 (MMP-2 and MMP-9) in papillary thyroid cancer cell line, B-CPAP cells. The effect of CX and VPA on B-CPAP cells viability and apoptosis were investigated using MTT assay and annexin V/7-AAD flowcytometry, respectively...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Mohammad Hadi Zarei, Seyed Farshad Hosseini Shirazi, Marjan Aghvami, Jalal Pourahmad
Perfluorinated compounds (PFCs) such as perfluorooctanesulfonate (PFOS) are stable chemicals that accumulate in biological matrix. Toxicity of these compounds including immunotoxicity has been demonstrated in experimental models and wildlife. Although limited number of studies examined the effects of PFOS on human lymphocytes but so far no research has investigated the complete mechanisms of PFOS cytotoxicity toward human lymphocytes. The main goal of this investigation was to find out the mechanisms underlying the cytotoxic effect of PFOS toward human lymphocytes using accelerated cytotoxicity mechanisms screening (ACMS) technique...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Parisa Ebrahimisadr, Fatemeh Ghaffarifar, John Horton, Abdolhosein Dalimi, Zohreh Sharifi
The parasites of genus Leishmania are the causative agents of one of the most widespread and devastating diseases . According to follow-up data, these medications may provoke adverse drug reactions, drug resistance, relapse, as well as financial burden . The mechanism of action of opioid drugs is primarily exerted via transmembrane G-protein coupled receptors. One of the potent synthetic immunomodulator agents is imiquimod with low molecular weight and unknown mechanism of action. Monocyte and macrophage are the primary site of action for imiquimod...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Mohamad Naderi Alizadeh, Mohsen Rashidi, Ahad Muhammadnejad, Taraneh Moeini Zanjani, Seyed Ali Ziai
Umbelliprenin is a sesquiterpene coumarin with vitro anti-carcinogenic activities. The aim of this study was to investigate the antitumor effects of umbelliprenin in animal models of colorectal cancer. The cytotoxic effects of umbelliprenin were explored on CT26 and L929by MTT assay. In this study, colorectal tumors developed in mice by intradermal injection of CT26 cell line. Tumor size, serum levels of IFN-γ and IL-4 by ELISA, and Ki-67, MMP2, MMP9, VEGF and E-cadherin markers by IHC method were evaluated...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Zeinab Vafaei-Pour, Mohammad Shokrzadeh, Monireh Jahani, Fatemeh Shaki
Gestational diabetes is defined as carbohydrate intolerance with onset or first recognition during pregnancy. Diabetes during pregnancy increases the incidences of congenital anomalies, in a mother and her embryo. Oxidative stress has been implicated to be responsible in diabetic embryopathy. In this study, we used nanoceria as an antioxidant for amelioration of diabetic embryopathy in diabetic mice. The female mice were divided into 5 groups (6 mice per group). Diabetes was induced by a single dose of streptozotocin (60 mg/kg IP) that dissolved in citrate buffer (pH = 4...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Mohammad Hassan HoushdarTehrani, Abdolhamid Bamoniri, Bi Bi Fatemeh Mirjalili, Mohammadreza Gholibeikian
In this work, linear and cyclic disulfide heptapeptides of Longicalycinin A have been successfully synthesized by solid phase methodology with Fmoc /t-Bu and solution phase, respectively. 2-Chlorotrityl chloride resin (2-CTC) was used as a solid support. The synthesized linear disulfide analogue of Longicalycinin A was cleaved from the resin as a protected peptide. The final deprotection was performed by treatment with TFA 95% containing scavengers to achieve the deprotected linear disulfide analogue of Longicalycinin A which was characterized by different instrumental methods using LC-MS and FT-IR...
2018: Iranian Journal of Pharmaceutical Research: IJPR
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