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Iranian Journal of Pharmaceutical Research: IJPR

Alwan Al-Qushawi, Ali Rassouli, Fatemeh Atyabi, Seyed Mostafa Peighambari, Mehdi Esfandyari-Manesh, Gholam Reza Shams, Azam Yazdani
Tilmicosin (TLM) is an important antibiotic in veterinary medicine with low bioavailability and safety. This study aimed to formulate and evaluate physicochemical properties, storage stability after lyophilization, and antibacterial activity of three TLM-loaded lipid nanoparticles (TLM-LNPs) including solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and lipid-core nanocapsules (LNCs). Physicochemical parameters such as particle size-mean diameter, polydispersity index, zeta potential, drug encapsulation efficiency (EE), loading capacity, and morphology of the formulations were evaluated and the effects of various cryoprotectants during lyophilization and storage for 8 weeks were also studied...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Gholamhossein Mehralian, Jafar Babapour, Farzad Peiravian
In the current competitive market, service quality management is the key to the survival and success of businesses. SERVQUAL is a popular service quality measurement scale (SQMS) that has served as a basis for subsequent research on service quality; it has been used for testing different aspects of service quality in a market. The purpose of our study is, therefore, to develop a service quality measurement scale (SQMS) for the distributor-retailer interface of Pharm supply chains (PSC) in Iran. A survey was performed to collect data from pharmacies located in Tehran...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Marzieh Beigom Khezri, Morteza Delkhosh Reihany, Sonia Oveisy, Navid Mohammadi
Melatonin has been suggested as a new natural pain killer in inflammatory pain and during surgical procedures. We designed this randomized double-blind controlled study to evaluate the analgesic efficacy and also optimal preemptive dose of melatonin in patients undergoing cesarean section under spinal anesthesia . One hundred twenty patients scheduled for cesarean section under spinal anesthesia were randomly allocated to one of three groups of 40 each to receive melatonin 3 milligram (mg) (group M3), melatonin 6 mg (group M6) or placebo (group P) sublingually 20 min before the spinal anesthesia...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Cong-Ping Wang
To investigate acute kidney injury (AKI) in children with acute lymphoblastic leukemia (ALL) who received high dose methotrexate (MTX) chemotherapy and explore the corresponding treatment. Methods 180 children who received high dose MTX chemotherapy were observed with serum MTX concentration and serum creatinine. Patients with AKI of stage 3 or poor response to conventional treatment were performed on hemodialysis and assessed the treatment outcome. Results 9 patients (5%) have appeared AKI, including 7 cases of AKI of stage 3...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mojtaba Mojtahedzadeh, Legese Chelkeba, Mona Ranjvar-Shahrivar, Atabak Najafi, Majid Moini, Farhad Najmeddin, Kourosh Sadeghi, Khosro Barkhordari, Azin Gheymati, Arezoo Ahmadi
Abdominal aortic aneurysm (AAA) is widely considered as the disease of elderly white men. Inflammation is one of the most well-known mechanisms involved in the pathogenesis of AAA. Magnesium is one of the most important minerals in the body with established anti-inflammatory effects. In this study, we aimed to investigate the impact of Mg loading following AAA surgery on two inflammation markers, IL-6 and CRP, as well as patient's outcome. This study was conducted as a randomized clinical trial on 18 patients (divided into two groups) after surgical correction of Acute Aortic Aneurysm (AAA)...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Fatemeh Sheikhmoonesi, Mehran Zarghami, Shima Mamashli, Jamshid Yazdani Charati, Romina Hamzehpour, Samineh Fattahi, Rahil Azadbakht, Zahra Kashi, Shahram Ala, Mona Moshayedi, Habibollah Alinia, Narjes Hendouei
In this study, the aim was to determine whether adding vitamin D to the standard therapeutic regimen of schizophrenic male patients with inadequate vitamin D status could improve some aspects of the symptom burden or not. This study was an open parallel label randomized clinical trial. Eighty patients with chronic stable schizophrenia with residual symptoms and Vitamin D deficiency were recruited randomly and then received either 600000 IU Vitamin D injection once along with their antipsychotic regimen or with their antipsychotic regimen only...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Shahnaz Bahadori, Arman Ahmadzadeh, Mohammad Reza Shams Ardekani, Mohammad Kamalinejad, Mansoor Keshavarz, Jamshid Salamzadeh
Rheumatoid arthritis (RA) patients are vulnerable to cardiovascular morbidity and mortality in which atherosclerosis plays a major role. In this study, the lipid profile and fasting blood sugar (FBS) of RA patients receiving a complementary medicine of olive and fig, as add-on therapy for routine disease-modifying antirheumatic drugs (DMARDs) regimen containing low dose methotrexate (MTX), were studied. A randomized controlled clinical trial was designed. Adult RA patients were randomly allocated in two groups receiving routine DMARDs regimen (control group) and routine DMARDs regimen plus the herbal supplementary formulation of olive oil, fig and olive fruits (intervention group)...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Fatemeh Ardestani
Mycophenolic acid is a secondary extracellular metabolite of Penicillium strains with numerous pharmaceutical properties such as antibiotic and immunosuppressive uses. The aim of this work is the survey of the effect of phenylglyoxal and n-ethylmaleimide concentration in culture medium on mycophenolic acid production by Penicillium brevi-compactum ATCC16024 was investigated. Batch submerged fermentation was performed in 250 mL shake flasks at 24 °C and 200 rpm in a rotary shaker for 300 h using a basic culture medium containing different concentrations of phenylglyoxal and n-ethylmaleimide ranged from 0 to 20 mg...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mohamed Ghareib, Medhat Abu Tahon, Mona Mostafa Saif, Wafaa El-Sayed Abdallah
The development of green approaches for the biosynthesis of silver nanoparticles (AgNPs) is of prime significance in the field of nanotechnology research. A fast and eco-friendly protocol for the biosynthesis of extracellular AgNPs using culture supernatant (CS) from the fungus Cunninghamella phaeospora was studied in this work. This CS was proved as a potential new source for the extracellular biosynthesis of AgNPs. The AgNPs were formed at 100 (o)C and pH 9 within four min of contact between CS and 1mM silver nitrate (AgNO3) solution...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Omid Zarei, Siavoush Dastmalchi, Maryam Hamzeh-Mivehroud
Yeasts, especially Saccharomyces cerevisiae, are one of the oldest organisms with broad spectrum of applications, owing to their unique genetics and physiology. Yeast extract, i.e. the product of yeast cells, is extensively used as nutritional resource in bacterial culture media. The aim of this study was to develop a simple, rapid and cost benefit process to produce the yeast extract. In this procedure mechanical methods such as high temperature and pressure were utilized to produce the yeast extract. The growth of the bacteria feed with the produced yeast extract was monitored in order to assess the quality of the product...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Saied Goodarzi, Abbas Hadjiakhoondi, Narguess Yassa, Mahnaz Khanavi, Zahra Tofighi
There are many efforts for identification of natural compounds from dietary or medicinal plants. Young roots and aerial parts of A. persicus have been used as food additive or salad vegetable in some parts of Iran. In this study, different fractions of the root extract of A. persicus were subjected for isolation and purification of secondary metabolites. The methanol extract of the roots was fractionated with hexane (HE), chloroform (CL), ethyl acetate (EA) and methanol (ME). Five novel compounds were isolated from HE, CL and EA using different chromatographic techniques and were identified by (1)H-NMR, (13)C-NMR, 2D-NMR and MS spectroscopic methods...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Maryam Niyyati, Samira Dodangeh, Jacob Lorenzo-Morales
Acanthamoeba keratitis (AK) is a sight-threating infection of the cornea that mostly affects contact lens wearers. Until now, AK treatment remains very difficult due to the existence of a highly resistant cyst stage in the life cycle of Acanthamoeba which is extremely resistant to most of the available anti-amoebic compounds. Moreover, current treatment of AK is usually based in the combination of various therapeutic agents such as polyhexamethylene biguanide or chlorhexidine and propamidine isethionate. However, all the mentioned compounds have also showed toxic side effects on human keratocytes and presented poor cysticidal effect at the concentrations currently used in the established AK treatments...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Bo Wei, Zhong-Duo Yang, Dan-Feng Shi, Xiao-Jun Yao, Ming-Gang Wang
Seven stilbenes and one catechin were bioactivity-guidedly isolated from the rhizomes of Rheum palmatem. Their structures were identified as piceatannol (1), resveratrol (2), piceid (3), rhapontigenin (4), piceatannol-3´-O-β-D-glucopyranoside (5), rhaponticin (6), catechin (7) and desoxyrhapontigenin (8). Anti-monoamine oxidase (MAO) activities of compounds 1-8 were tested. Compounds 1 and 8 showed significant MAO inhibitory activities with IC50 values 16.4 ± 1.5 μM and 11.5 ± 1.1, respectively, when the IC50 value of iproniazid as a standard was 6...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Parisa Seyedemadi, Mehdi Rahnema, Mohammad Reza Bigdeli, Shahrebano Oryan, Hassan Rafati
The prevention of BBB breakdown and the subsequent vasogenic edema are important parts of the medical management of ischemic stroke. The purpose of this study was to investigate the ischemic tolerance effect of Rosmarinus officinalis leaf hydro-alcoholic extract (RHE). Five groups of animals were designed: sham (underwent surgery without MCAO) and MCAO groups, the MCAO groups were pretreated orally by gavages with RHE (50, 75, and 100 mg/Kg/day), daily for 30 days. Two hours after the last dose, serum lipid levels were determined and then the rats were subjected to 60 min of middle cerebral artery occlusion followed by 24 h of reperfusion...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mohammad Hossein Boskabady, Milad Hashemzehi, Mohammad Reza Khazdair, Vahid Reza Askari
Thestimulatory effect of the extract of Portulaca oleracea (P. olerace) on β-adrenoceptor of tracheal smooth muscle was examined.To examine β-adrenoceptor stimulatory effect, concentration response curve to isoprenaline was obtained in pre-contracted tracheal smooth muscle in the presence of three concentrations of aqueous-ethanolic extract, propranolol, and saline. Values of EC50 (the effective concentration of isoprenaline, causing 50% of maximum response) and dose ratio-1(CR-1) were measured. This effect was tested innon-incubated tracheal smooth muscle (group 1) and incubated tissues with chlorpheniramine (group 2)...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Seyed Mohammad Abedi, Fateme Yarmand, Mina Motallebnejad, Maryam Seyedmajidi, Dariush Moslemi, Ali Bijani, Seyed Jalal Hosseinimehr
The aim of this study was to investigate the radioprotective effect of thymol as a natural product against salivary glands dysfunction induced by ionizing radiation in rats. The rats were treated with thymol at dose of 50 mg/Kg before exposure to ionizing radiation at dose 15 Gy. Salivary gland function was evaluated with radioisotope scintigraphy and then salivary gland to background counts ratio was calculated. Ionizing radiation caused significant salivary glands dysfunction at the 3(th) and the 70(th) days with reduction in radioactivity uptake in salivary glands...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mahboubeh Jahangirvand, Fatemeh Yazdi, Marzieh Moradi, Abbas Haghparast
Orexin, mainly produced by orexin-expressing neurons in the lateral hypothalamus (LH), plays an important role in pain modulation. Moreover, it is shown that the nucleus accumbens (NAc) is one of the important areas involved in this modulation. Orexin-1 (OX1) and orexin-2 (OX2) receptors are densely distributed in the NAc. The study investigated the involvement of OX1 receptors in the NAc on antinociception induced by intra-LH administration of carbachol in formalin test. Rats were unilaterally implanted by two separate cannulae into the LH and NAc...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Hamed Shafaroodi, Farnaz Shahbek, Mehrdad Faizi, Farzad Ebrahimi, Leila Moezi
Creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. Creatine supplements have shown beneficial effects on neurological disorders including Parkinson׳s disease, Huntington›s disease, amyotrophic lateral sclerosis, as well as Alzheimer›s disease and stroke. However, the potential benefits of creatine for patients with convulsive disorders remain poorly defined. While some authors did not suggest any anti- or pro-convulsant roles for creatine treatment, others suggest that creatine may be an anticonvulsant agent...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Farzad Kahrizi, Ahmad Salimi, Farshid Noorbakhsh, Mehrdad Faizi, Freshteh Mehri, Parvaneh Naserzadeh, Nima Naderi, Jalal Pourahmad
In this study we investigated the additive effect of mercury on the brain mitochondrial dysfunction in experimental autoimmune encephalomyelitis (EAE) model. Experimental animals (female C57BL/6 mice) are divided into four groups (n = 8); control, Hg, EAE, EAE with Hg. EAE model of MS induced by injecting myelin oligodendrocyte glycoprotein (MOG). Neurobehavioral alterations are recorded and then mice were sacrificed at day 28 and brain mitochondria were isolated and mitochondrial toxicity parameters including mitochondrial swelling, reactive oxygen species (ROS) formation, collapse of mitochondrial membrane potential (MMP) and cytochrome c release were measured...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Mehdi Aliomrani, Mohammad Ali Sahraian, Hamid Shirkhanloo, Mohammad Sharifzadeh, Mohammad Reza Khoshayand, Mohammad Hossein Ghahremani
Since industrial revolution heavy metals such as lead (Pb) and cadmium (Cd) have been extensively dispersed in environment which, unknown biological effects and prolong biological half-life make them as a major hazard to human health. In addition, the sharp increase in Multiple sclerosis incidence rateshas been recorded in Iran. The propose of this study was to measuring blood lead and cadmium concentration and their correlation with smoking habit in a group of 69 RRMS patients and 74 age/gender-matched healthy individuals resident in Tehran as most polluted city in Iran...
2016: Iranian Journal of Pharmaceutical Research: IJPR
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