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Postȩpy Dermatologii i Alergologii

Aleksandra Dańczak-Pazdrowska, Katarzyna Pawlaczyk-Gabriel, Monika Bowszyc-Dmochowska, Adriana Polańska, Marcin Gabriel, Zofia Gabriel, Ryszard Żaba, Zygmunt Adamski
No abstract text is available yet for this article.
August 2018: Postȩpy Dermatologii i Alergologii
Magdalena Żychowska, Aleksandra Batycka-Baran, Joanna Maj, Wojciech Baran
No abstract text is available yet for this article.
August 2018: Postȩpy Dermatologii i Alergologii
Piotr Krzeminski, Aleksandra Lesiak, Joanna Narbutt
No abstract text is available yet for this article.
August 2018: Postȩpy Dermatologii i Alergologii
Urszula Adamska, Anna Slinko, Agnieszka Białecka, Kaja Męcińska-Jundziłł, Piotr Adamski, Rafał Czajkowski
No abstract text is available yet for this article.
August 2018: Postȩpy Dermatologii i Alergologii
Anna Cwynar, Dorota Olszewska-Słonina, Rafał Czajkowski, Elżbieta Piskorska, Iga Hołyńska-Iwan, Piotr Kaczorowski, Magdalena Lampka
No abstract text is available yet for this article.
August 2018: Postȩpy Dermatologii i Alergologii
Dominika Wcisło-Dziadecka, Joanna Gola, Beniamin Grabarek, Urszula Mazurek, Ligia Brzezińska-Wcisło, Eugeniusz J Kucharz
Introduction: Tumour necrosis factor (TNF-α) is one of the main cytokines participating in inflammation and immune response. Biological effects of the cytokine action, mediated by two receptors: TNFRSF1A and TNFRSF1B involve activation of many signal paths, thus change the transcription activity of many genes. The mechanism of action of an anti-TNF medicine consists in blocking TNF-α though preventing activation of signal paths. Aim: To single out mRNA and microRNA genes relating to TNF-α signal paths, the expression of which could indicate sensitivity of cells to the medicine in question...
August 2018: Postȩpy Dermatologii i Alergologii
Mateusz Szewczyk, Jakub Pazdrowski, Paweł Golusiński, Aleksandra Dańczak-Pazdrowska, Mariola Pawlaczyk, Jacek Sygut, Andrzej Marszałek, Wojciech Golusiński
Introduction: While it is clear that individuals with outdoor occupations are at a significantly greater risk of developing cutaneous squamous cell carcinoma (cSCC), no previous studies have investigated the potential association between the tumour grade and occupation in this patient population. Aim: To assess occupation as a risk factor for the development of high-grade cSCC. Secondarily, to determine the association between the tumour grade and other clinical characteristics...
August 2018: Postȩpy Dermatologii i Alergologii
Magdalena Czarnecka-Operacz, Joanna Szulczyńska-Gabor, Kinga Leśniewska, Ewa Teresiak-Mikołajczak, Paweł Bartkiewicz, Dorota Jenerowicz, Krzysztof Wiktorowicz, Zygmunt Adamski
Introduction: Since urticaria is a persisting inflammatory disease it is important to establish the prognostic factors for the duration and severity of the disease. Aim: To evaluate serum concentrations of selected acute-phase proteins (APP) in patients with various forms of urticaria as compared to healthy volunteers and also to analyze these concentrations in different types of urticaria. Additionally, to evaluate the correlation between serum levels of selected APP and disease activity...
August 2018: Postȩpy Dermatologii i Alergologii
Selma Korkmaz, Sezin Kuru Fıçıcıoğlu
Introduction: Acne vulgaris (AV) is a chronic inflammatory disorder of the pilosebaceous unit. Although various mechanisms have been indicated in the etiopathogenesis of acne vulgaris, the exact pathophysiology is still unknown. Aim: To investigate the level of calprotectin in acne vulgaris and its levels relationship with disease severity. Material and methods: A total of 66 AV patients, who were divided into 33 mild and 33 moderate-severe cases, and 30 healthy controls were enrolled in the study...
August 2018: Postȩpy Dermatologii i Alergologii
Eleonora Nucera, Anna Giulia Ricci, Angela Rizzi, Simona Mezzacappa, Alessia Di Rienzo, Valentina Pecora, Giampiero Patriarca, Alessandro Buonomo, Arianna Aruanno, Domenico Schiavino
Introduction: The first therapeutic choice for food allergy is avoidance of the responsible food, but when this approach is not possible, specific oral desensitization could be considered as a good alternative. It is not clear yet whether the acquired tolerance is transient or persistent. Aim: We report on a subset of 13 patients of a larger study, treated successfully with specific oral tolerance induction who experienced secondary loss of tolerance after a period of allergen avoidance...
August 2018: Postȩpy Dermatologii i Alergologii
Andrzej Witusik, Łukasz Mokros, Marcin Kosmalski, Michał Panek, Katarzyna Nowakowska-Domagała, Kasper Sipowicz, Piotr Kuna, Tadeusz Pietras
Introduction: Poor asthma control is probably associated with both biological and psychological factors. Type D pattern of behavior is characterized by negative emotionality and inhibition in social relationships. It was previously found to be associated with cardiovascular diseases. Aim: To evaluate the correlation between the degree of asthma control and the severity of the components of type D behavior pattern. Material and methods: The research was conducted on a group of 117 subjects with bronchial asthma...
August 2018: Postȩpy Dermatologii i Alergologii
Dorota Mrozek-Budzyn, Renata Majewska, Agnieszka Kieltyka, Malgorzata Augustyniak
Introduction: Vaccine opponents indicate that the infant's immune system is inadequately developed to handle multiple vaccines which may overwhelm the immune system, leading to allergic diseases. Aim: To verify the association between the vaccine antigen overload derived from DTwP and the development of atopic sensitization and allergic diseases. Material and methods: Data from an earlier established birth cohort in Krakow, followed up to the 6th year of life were used...
August 2018: Postȩpy Dermatologii i Alergologii
Grażyna Stryjewska-Makuch, Małgorzata A Janik, Grażyna Lisowska, Bogdan Kolebacz
Introduction: Chronic sinusitis (CRS) is phenotypically divided into inflammation with polyps (CRSwNP) or without polyps (CRSsNP). Aim: To try to explain the reasons for isolated sinusitis by analysing medical history as well as anatomical and bacteriological data. Material and methods: In 2016, endoscopic surgery was performed in 103 patients with CRSsNP within 6 months. The authors evaluated 28 patients with lesions in one sinus. Results: The patients did not report any previous facial trauma, dental procedures, there were no odontogenic causes of the disease...
August 2018: Postȩpy Dermatologii i Alergologii
Aleksandra Lesiak, Igor A Bednarski, Anna Maćkowska, Zuzanna Łukasik, Anna Woźniacka, Irmina Olejniczak-Staruch, Joanna Narbutt
Introduction: Omalizumab (Xolair) originally intended to reduce symptoms of moderate to severe asthma uncontrollable with steroids is the first monoclonal antibody approved for treatment of chronic spontaneous urticaria in 2014. Aim: To evaluate response and potential side effects to omalizumab treatment in clinical practice. Material and methods: Eleven patients (6 males and 5 females) were recruited into the study. All participants signed written informed consent before enrollment to the study...
August 2018: Postȩpy Dermatologii i Alergologii
Selma Korkmaz
Introduction: Psoriasis vulgaris (PV) is a common inflammatory skin disease characterized by incomplete differentiation and hyperproliferation of epidermal keratinocytes. Platelets play a role in inflammatory reactions and the immune response and may be activated by a variety of stimulants. Studies in recent years have shown increased incidence of metabolic syndrome (MetS) in psoriasis patients. However, the mean platelet volume (MPV) and platelet distribution width (PDW) values have not been assessed in PV accompanied by MetS...
August 2018: Postȩpy Dermatologii i Alergologii
Magdalena Pirowska, Aleksander Obtułowicz, Sylwia Lipko-Godlewska, Anna Goździalska, Katarzyna Podolec, Anna Wojas-Pelc
Introduction: The incidence of metabolic syndrome is estimated at 15-24% in the general population and at 30-50% in patients with psoriasis. A probable cause of the described correlation is a constant release in chronic dermatosis of proinflammatory cytokines and their influence on individual systems and organs. Aim: Assessment of the concentration of the proinflammatory cytokines (IL-12, IL-23, IL-17 and TNF-α) in blood serum and their correlation with the intensity of skin lesions, the presence of psoriatic arthritis and the risk of development of obesity and metabolic syndrome...
August 2018: Postȩpy Dermatologii i Alergologii
Milena Wojciechowska, Magdalena Żbikowska-Gotz, Luiza Marek-Józefowicz, Michał Przybyszewski, Jacek Gocki, Zbigniew Bartuzi
Introduction: Atopic dermatitis (AD) is a chronic inflammatory dermatosis, often with a concomitant allergy. The ImmunoCAP ISAC (Immuno Solid-Phase Allergen Chip) test is a novel method to determine the allergenic phenotype in a given patient. Aim: In this study, we used the ImmunoCAP ISAC test to analyze allergic phenotypes in adult patients with AD. Material and methods: The study included 19 adult patients with AD. The severity of AD was assessed using SCORAD index...
August 2018: Postȩpy Dermatologii i Alergologii
Joanna Bartosińska, Ewelina Zakrzewska, Joanna Purkot, Anna Michalak-Stoma, Małgorzata Kowal, Dorota Krasowska, Grażyna Chodorowska, Krzysztof Giannopoulos
Introduction: Psoriasis with and without arthritis have common immunological mechanisms which among others involve the interactions between cytokines produced by T cells, including Th1, Th17 and Th22. Although quite a lot is known about psoriasis pathogenesis, the cause of chronic immune activation and response in the disease remains unclear. One of the negative regulators of the immune system is programmed death 1 (PD-1). Aim: To assess the expression level of PD-1 in the peripheral T cells of psoriatic patients with and without arthritis...
August 2018: Postȩpy Dermatologii i Alergologii
Zhiliang Li, Ke Jing, Suo Li, Suying Feng
Immunoglobulin A (IgA) is the most common subtype of antibodies in mucosal surfaces. In most of autoimmune bullous diseases, however, immunoglobulin G (IgG) is the main pathogenic antibody that plays a role through complementation. The IgA antibody for epidermal connection protein can be found in the sera of some patients with blistering skin disease. Of these patients, some have the IgA antibody in their sera, while others have IgG and IgA antibodies. IgA-related autoimmune bullous diseases are less common in clinical practice...
August 2018: Postȩpy Dermatologii i Alergologii
Agnieszka Osmola-Mańkowska, Ewa Teresiak-Mikołajczak, Marzena Skrzypczak-Zielińska, Zygmunt Adamski
The concept of personalized medicine is a new individualized approach which helps application of the targeted therapy. In fact, tailored medicine is mostly present in the field of life-threatening diseases such as oncology. However, skin diseases as such might be regarded as a potential area of implementation of this approach in the future. Stratified medicine in polygenetic and heterogeneous diseases, such as psoriasis, is more complex. Rapid development of science and novel molecular techniques led to better understanding of molecular pathogenetic pathways of many diseases including psoriasis...
August 2018: Postȩpy Dermatologii i Alergologii
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