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Journal of Blood Transfusion

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https://www.readbyqxmd.com/read/29181226/blood-safety-status-in-who-african-region-countries-lessons-learnt-from-mauritius
#1
André Loua, Janaki Sonoo, Laurent Musango, Jean Baptiste Nikiema, Thomas Lapnet-Moustapha
In 2001, the WHO Office for Africa adopted a strategy for blood safety defining four targets. This paper describes the progress made by Mauritius in the implementation of this strategy. The blood safety indicators were collected and compared with the norms recommended by WHO. The country has formulated its blood policy and developed a strategic plan for its implementation since 2004. The total number of blood donations increased from 31,228 in 2002 to 43,742 in 2016, giving an annual blood collection rate evolving from 26...
2017: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/28127495/quality-and-safety-of-blood-products
#2
EDITORIAL
Sandra Ramirez-Arcos, Denese C Marks, Jason P Acker, William P Sheffield
No abstract text is available yet for this article.
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/28070449/knowledge-attitudes-practices-and-factors-associated-with-voluntary-blood-donation-among-university-students-in-kilimanjaro-tanzania
#3
Elionora Elias, Wilhellmuss Mauka, Rune N Philemon, Damian J Damian, Michael J Mahande, Sia E Msuya
Background. Understanding the knowledge and awareness of blood donation among potential blood donors in the population, like young people, and the associated attitudes and practices is important. Methodology. This was a cross-sectional study whereby a self-administered questionnaire was used to collect information from the consenting participants. Results. A total of 422 participants were enrolled. Their mean age was 24.2 (SD 3.6) years. Of the 422, 30% have ever donated blood. 55% of those who had ever donated were repeated blood donors...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/28070448/quality-assessment-of-established-and-emerging-blood-components-for-transfusion
#4
REVIEW
Jason P Acker, Denese C Marks, William P Sheffield
Blood is donated either as whole blood, with subsequent component processing, or through the use of apheresis devices that extract one or more components and return the rest of the donation to the donor. Blood component therapy supplanted whole blood transfusion in industrialized countries in the middle of the twentieth century and remains the standard of care for the majority of patients receiving a transfusion. Traditionally, blood has been processed into three main blood products: red blood cell concentrates; platelet concentrates; and transfusable plasma...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/28053805/could-microparticles-be-the-universal-quality-indicator-for-platelet-viability-and-function
#5
REVIEW
Elisabeth Maurer-Spurej, Kate Chipperfield
High quality means good fitness for the intended use. Research activity regarding quality measures for platelet transfusions has focused on platelet storage and platelet storage lesion. Thus, platelet quality is judged from the manufacturer's point of view and regulated to ensure consistency and stability of the manufacturing process. Assuming that fresh product is always superior to aged product, maintaining in vitro characteristics should preserve high quality. However, despite the highest in vitro quality standards, platelets often fail in vivo...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/28050312/effectiveness-of-provider-education-followed-by-computerized-provider-order-entry-alerts-in-reducing-inappropriate-red-blood-cell-transfusion
#6
Vijay M Patel, Anna W Rains, Christopher T Clark
To reduce the rate of inappropriate red blood cell transfusion, a provider education program, followed by alerts in the computerized provider order entry system (CPOE), was established to encourage AABB transfusion guidelines. Metrics were established for nonemergent inpatient transfusions. Service lines with high order volume were targeted with formal education regarding AABB 2012 transfusion guidelines. Transfusion orders were reviewed in real time with email communications sent to ordering providers falling outside of AABB recommendations...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/28003931/stability-of-thawed-apheresis-fresh-frozen-plasma-stored-for-up-to-120-hours-at-1%C3%A2-c-to-6%C3%A2-c
#7
William P Sheffield, Varsha Bhakta, Qi-Long Yi, Craig Jenkins
Regulations concerning the storage of transfusable plasma differ internationally. In Canada, plasma obtained from whole blood donations and frozen within 24 hours of phlebotomy (frozen plasma, FP) may be thawed and transfused within 120 hours of refrigerated storage. However, plasma frozen within 8 hours of phlebotomy following apheresis donation (FFPA) must be transfused within 24 hours of thawing and refrigeration. Our objectives were to measure coagulation factors (F) V, VII, and VIII, fibrinogen activities, and the prothrombin time (PT) in thawed refrigerated FFPA at 0, 24, and 120 hours of storage and to compare these values to those in thawed refrigerated FP...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/27957384/mitigating-the-risk-of-transfusion-transmitted-dengue-in-australia
#8
Kelly Rooks, Clive R Seed, Jesse J Fryk, Catherine A Hyland, Robert J Harley, Jerry A Holmberg, Denese C Marks, Robert L P Flower, Helen M Faddy
Dengue viruses (DENV 1-4) are a risk to transfusion safety, with several transfusion-transmitted (TT) cases reported globally. DENV 1-4 are endemic in over 100 countries, with seasonal outbreaks occurring in northeastern Australia. To mitigate TT-DENV risk in Australia, fresh blood components are not manufactured from donors returning from any area (domestic/overseas) with known dengue transmission. Alternatively, TT-DENV risk may be mitigated using an appropriate blood donor screening assay. We aimed to determine the rate of dengue infection in donors during dengue outbreaks in Australia...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/27891290/a-comparative-study-of-assay-performance-of-commercial-hepatitis-e-virus-enzyme-linked-immunosorbent-assay-kits-in-australian-blood-donor-samples
#9
Ashish C Shrestha, Robert L P Flower, Clive R Seed, Susan L Stramer, Helen M Faddy
Hepatitis E virus (HEV) is transfusion-transmissible and therefore poses a risk to blood transfusion safety. Seroprevalence studies are useful for estimating disease burden and determining risk factors. Considerable variability in the sensitivity of HEV antibody detection assays exists. This study aimed to compare the performances of commercially available HEV enzyme-linked immunosorbent assays (ELISA) in Australian blood donor samples. Plasma samples that tested positive (n = 194) or negative (n = 200) for HEV IgG (Wantai HEV IgG ELISA) were selected...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/27774338/quantification-of-cell-free-dna-in-red-blood-cell-units-in-different-whole-blood-processing-methods
#10
Andrew W Shih, Vinai C Bhagirath, Nancy M Heddle, Jason P Acker, Yang Liu, John W Eikelboom, Patricia C Liaw
Background. Whole blood donations in Canada are processed by either the red cell filtration (RCF) or whole blood filtration (WBF) methods, where leukoreduction is potentially delayed in WBF. Fresh WBF red blood cells (RBCs) have been associated with increased in-hospital mortality after transfusion. Cell-free DNA (cfDNA) is released by neutrophils prior to leukoreduction, degraded during RBC storage, and is associated with adverse patient outcomes. We explored cfDNA levels in RBCs prepared by RCF and WBF and different storage durations...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/27774337/a-new-proof-of-concept-in-bacterial-reduction-antimicrobial-action-of-violet-blue-light-405%C3%A2-nm-in-ex-vivo-stored-plasma
#11
Michelle Maclean, John G Anderson, Scott J MacGregor, Tracy White, Chintamani D Atreya
Bacterial contamination of injectable stored biological fluids such as blood plasma and platelet concentrates preserved in plasma at room temperature is a major health risk. Current pathogen reduction technologies (PRT) rely on the use of chemicals and/or ultraviolet light, which affects product quality and can be associated with adverse events in recipients. 405 nm violet-blue light is antibacterial without the use of photosensitizers and can be applied at levels safe for human exposure, making it of potential interest for decontamination of biological fluids such as plasma...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/27559490/epidemiology-of-transfusion-transmitted-infection-among-patients-with-%C3%AE-thalassaemia-major-in-pakistan
#12
Rizwan Ahmed Kiani, Muhammad Anwar, Usman Waheed, Muhammad Javaid Asad, Saleem Abbasi, Hasan Abbas Zaheer
Introduction. Transfusion Transmitted Infections (TTIs) continue to be a major risk in transfusions in many parts of the world. The transfusion-dependent β-thalassaemia patients are particularly at risk of acquiring TTIs. The current study was undertaken to estimate the prevalence of TTIs in transfusion-dependent β-thalassaemia patients. Material and Methods. A cross-sectional study of 1253 multitransfused thalassaemia major patients was conducted in five different centres of Islamabad, Rawalpindi, and Karachi...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/27516920/knowledge-attitude-and-practice-of-adult-population-towards-blood-donation-in-gondar-town-northwest-ethiopia-a-community-based-cross-sectional-study
#13
Mulugeta Melku, Betelihem Terefe, Fikir Asrie, Bamlaku Enawgaw, Tadele Melak, Yakob Gebregziabher Tsegay, Mohamedamin Areba, Elias Shiferaw
Background. Though World Health Organization recommends 100% voluntary blood donation, the percentage of blood collected from voluntary blood donors and the average annual blood collection rate are extremely low in Ethiopia. The role of adults is crucial to meet the demand of safe blood. Thus, this study aimed to assess knowledge, attitude, and practice of adult population towards blood donation in Gondar town, Northwest Ethiopia. Method. A community based cross-sectional study was conducted among 768 adults...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/27293985/motivating-factors-and-potential-deterrents-to-blood-donation-in-high-school-aged-blood-donors
#14
Rachel Finck, Alyssa Ziman, Matthew Hoffman, Michelle Phan-Tang, Shan Yuan
Background. To ensure an adequate supply of blood, collection centers must design campaigns that successfully recruit and maintain an active donor pool. Understanding factors that motivate and deter individuals from donating may help centers develop targeted recruitment campaigns. These factors among high school aged blood donors have not yet been fully investigated. Study Design and Methods. A voluntary, anonymous survey was administered to student donors at high school mobile blood drives. The survey instrument asked the students to rate several potential motivating factors in their importance in the decision to donate blood and several potential deterring factors in their future decision whether or not to donate blood again...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/26942040/association-between-perioperative-blood-transfusions-and-clinical-outcomes-in-patients-undergoing-bladder-cancer-surgery-a-systematic-review-and-meta-analysis-study
#15
REVIEW
Juan P Cata, Javier Lasala, Greg Pratt, Lei Feng, Jay B Shah
Background. Perioperative blood transfusions are associated with poor survival in patients with solid tumors including bladder cancer. Objective. To investigate the impact of perioperative blood transfusions on oncological outcomes after radical cystectomy. Design. Systematic review and meta-analysis. Setting and Participants. Adult patients who underwent radical cystectomy for bladder cancer. Intervention. Packed red blood cells transfusion during or after radical cystectomy for bladder cancer. Outcome Measurements and Statistical Analysis...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/26783496/factors-associated-with-repeat-blood-donation-at-the-northern-zone-blood-transfusion-centre-in-tanzania
#16
Wilhellmuss I Mauka, Michael J Mahande, Sia E Msuya, Rune N Philemon
Background and Objective. The aim of this study was to determine factors associated with repeat blood donation. Methods. This was a cross-sectional study carried out among blood donors aged 18-65 years in northern Tanzania. The questionnaire was administered among 454 participants through the phone. Results. Of the 454 participants, the proportion of repeat donation was 63.9%. In the backward logistic regression analysis, the significant predictors were living in Arusha which had lower odds of repeat donation compared to those living in Kilimanjaro...
2015: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/26770871/low-dose-perioperative-intravenous-tranexamic-acid-in-patients-undergoing-total-knee-arthroplasty-a-double-blind-randomized-placebo-controlled-clinical-trial
#17
Mahdi Motififard, Mohammad Ali Tahririan, Mehdi Saneie, Sajad Badiei, Amin Nemati
Background and Objectives. The null hypothesis of this study was that TA has no effect on postsurgical bleeding in patients undergoing TKA. Methods. This study was a double-blind randomized trial. In the first group (T) patients received 500 mg of intravenous Tranexamic acid (TA) twice (once preoperatively and once 3 hours postoperatively) and in the second group (P) they received slow infusion of normal saline as placebo. The primary outcome of the study was the level of Hb 48 hours after surgery. Results...
2015: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/26664830/the-value-of-tranexamic-acid-in-reducing-blood-loss-following-hip-reconstruction-in-children-with-cerebral-palsy
#18
I Majid, S Alshryda, B Somanchi, E Morakis, A Foster
This is a retrospective study of 51 consecutive hip reconstructions in children with cerebral palsy performed between 2011 and 2013. Tranexamic acid (TXA) was used in 14 hip reconstructions only. Transfusion rate was higher, postoperative Hb was lower, and patients stayed longer in the TXA group. This did not reach a statistical significance (P = 0.75, 0.5, and 0.71, resp.). More than half of the patients who had TXA underwent bilateral hip reconstructions in comparison with 27% only in the non-TXA group. Bilateral hip reconstructions mean more surgery, more blood loss, and more blood transfusion...
2015: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/26491605/estimating-the-risk-of-abo-hemolytic-disease-of-the-newborn-in-lagos
#19
Alani Sulaimon Akanmu, Olufemi Abiola Oyedeji, Titilope Adenike Adeyemo, Ann Abiola Ogbenna
Background. ABO hemolytic disease of the newborn is the most common hemolytic consequence of maternofetal blood group incompatibility restricted mostly to non-group-O babies of group O mothers with immune anti-A or anti-B antibodies. Aim. We estimated the risk of ABO HDN with view to determining need for routine screening for ABO incompatibility between mother and fetus. Materials and Methods. Prevalence of ABO blood group phenotypes in blood donors at the donor clinic of the Lagos University Teaching Hospital and arithmetic methods were used to determine population prevalence of ABO genes...
2015: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/26448897/crash-2-study-of-tranexamic-acid-to-treat-bleeding-in-trauma-patients-a-controversy-fueled-by-science-and-social-media
#20
REVIEW
Sophia Binz, Jonathon McCollester, Scott Thomas, Joseph Miller, Timothy Pohlman, Dan Waxman, Faisal Shariff, Rebecca Tracy, Mark Walsh
This paper reviews the application of tranexamic acid, an antifibrinolytic, to trauma. CRASH-2, a large randomized controlled trial, was the first to show a reduction in mortality and recommend tranexamic acid use in bleeding trauma patients. However, this paper was not without controversy. Its patient recruitment, methodology, and conductance in moderate-to-low income countries cast doubt on its ability to be applied to trauma protocols in countries with mature trauma networks. In addition to traditional vetting in scientific, peer-reviewed journals, CRASH-2 came about at a time when advances in communication technology allowed debate and influence to be leveraged in new forms, specifically through the use of multimedia campaigns, social media, and Internet blogs...
2015: Journal of Blood Transfusion
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