Ursula S Sandau, Setty M Magaña, Júlia Costa, John P Nolan, Tsuneya Ikezu, Laura J Vella, Hannah K Jackson, Lissette Retana Moreira, Paola Loreto Palacio, Andrew F Hill, Joseph F Quinn, Kendall R Van Keuren-Jensen, Trevor J McFarland, Joanna Palade, Eric A Sribnick, Huaqi Su, Kostas Vekrellis, Beth Coyle, You Yang, Juan M Falcón-Perez, Rienk Nieuwland, Julie A Saugstad
Cerebrospinal fluid (CSF) is a clear, transparent fluid derived from blood plasma that protects the brain and spinal cord against mechanical shock, provides buoyancy, clears metabolic waste and transports extracellular components to remote sites in the brain. Given its contact with the brain and the spinal cord, CSF is the most informative biofluid for studies of the central nervous system (CNS). In addition to other components, CSF contains extracellular vesicles (EVs) that carry bioactive cargoes (e.g., lipids, nucleic acids, proteins), and that can have biological functions within and beyond the CNS...
January 2024: Journal of Extracellular Vesicles