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Japanese Clinical Medicine

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https://www.readbyqxmd.com/read/28811746/oral-care-and-prevention-of-pneumonia-in-hospitalized-patients-with-psychiatric-disorders-in-japan
#1
Atsushi Hamuro, Hideki Kawaguchi, Kazuaki Yamazoe, Minoru Honda, Ryuichi Tanaka
PURPOSE: Oral care in hospitalized patients with psychiatric disorders is important. However, some patients with psychiatric disorders cannot undergo oral care because of psychiatric symptoms and cognitive decline. The effect of a standardized oral hygiene intervention on the prevention of pneumonia in hospitalized patients with psychiatric disorders was investigated. METHOD: Patients were divided into 2 groups: control group (N = 259), patients without standardized intervention who were enrolled on April 2014 as the time point of baseline, and intervention group (N = 263), patients with standardized intervention who were enrolled on April 2015 as the time point of baseline...
2017: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/28680271/atherosclerotic-cardiovascular-risk-in-japan
#2
REVIEW
Shuko Nojiri, Hiroyuki Daida
Increased global mortality is associated with atherosclerosis, which appears to be independent of race. Cardiovascular disease is one of the leading causes of mortality and morbidity in Japan. Atherosclerosis, an inflammatory disease characterized by abnormal lipid accumulation and inflammation in the arterial wall, is the main underlying cause of cardiovascular disease. Numerous cardiovascular risk scores have been developed and are used to prioritize patients' treatment needs. The predictive performance of risk scores established in Western nations needs to be examined in Japanese populations...
2017: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/28469527/histologic-chorioamnionitis-amniotic-fluid-interleukin-6-krebs-von-den-lungen-6-and-transforming-growth-factor-%C3%AE-1-for-the-development-of-neonatal-bronchopulmonary-dysplasia
#3
Hisako Matsumura, Hiroyuki Ichiba, Satoshi Ohnishi, Mika Saito, Haruo Shintaku
BACKGROUND: Chorioamnionitis (CAM) is an important risk factor for the development of bronchopulmonary dysplasia (BPD) in preterm infants. OBJECTIVES: To evaluate the effects of CAM on the development of BPD using interleukin 6 (IL-6), Krebs von den Lungen 6 (KL-6), and transforming growth factor β1 (TGF-β1) in the amniotic fluid as markers for inflammation, lung injury, and fibrosis/remodeling, respectively. METHODS: Amniotic fluid concentrations of IL-6, KL-6, and TGF-β1 were measured with enzyme-linked immunosorbent assay or electro-chemiluminescence immunoassay...
2017: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/28469526/a-case-report-ovarian-sertoli-leydig-cell-tumor-with-hyperestrogenism-and-endometrial-hyperplasia-in-a-postmenopausal-woman
#4
Yoko Tsuzuki, Iwaho Kikuchi, Michio Nojima, Koyo Yoshida, Akane Hashizume, Shigeki Tomita
The patient was a 66-year-old woman, G2P2. The patient presented a chief complaint of irregular postmenopausal bleeding 1 month ago. A transvaginal ultrasonography showed that bilateral ovaries were not enlarged and uterine endometrium was thickened, measuring at 9 mm. As a result of endometrial curettage, the simple endometrial hyperplasia was revealed. A blood examination showed an elevated estradiol level of 67 pg/mL, an elevated level of testosterone 0.64 ng/mL, and a slightly suppressed follicle-stimulating hormone (FSH) level of 34...
2017: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/28469525/recommendation-of-repeated-ammonia-tests-for-intrahepatic-portal-systemic-shunt-without-cirrhosis-in-elderly-patients-with-psychiatric-symptoms
#5
Michiaki Abe, Temma Soga, Nobuya Obana, Kazumasa Seiji, Masao Tabata, Natsumi Saito, Ryutaro Arita, Takehiro Numata, Junichi Tanaka, Hitoshi Kuroda, Shin Takayama, Yutaka Kagaya, Tadashi Ishii
We report an elderly male patient with hyperammonemia induced by intrahepatic portal-systemic shunt without cirrhosis (IPSSwoC). The occasional emergence of his erratic behaviors was misdiagnosed as a psychiatric disorder. Regardless of his uneven symptoms, IPSSwoC was suspected due to his hyperammonemia. The contrast computed tomography of the abdomen revealed a congenital type of IPSSwoC. As blood ammonia levels are inconstant, repeated blood tests are recommended when this disease is suspected in elderly patients with psychiatric symptoms...
2017: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/28008299/kras-mutation-as-a-potential-prognostic-biomarker-of-biliary-tract-cancers
#6
Masaaki Yokoyama, Hiroaki Ohnishi, Kouki Ohtsuka, Satsuki Matsushima, Yasuo Ohkura, Junji Furuse, Takashi Watanabe, Toshiyuki Mori, Masanori Sugiyama
BACKGROUND: The aim of this study was to identify the unique molecular characteristics of biliary tract cancer (BTC) for the development of novel molecular-targeted therapies. MATERIALS AND METHODS: We performed mutational analysis of KRAS, BRAF, PIK3CA, and FBXW7 and immunohistochemical analysis of EGFR and TP53 in 63 Japanese patients with BTC and retrospectively evaluated the association between the molecular characteristics and clinicopathological features of BTC...
2016: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/27980448/linagliptin-has-wide-ranging-anti-inflammatory-points-of-action-in-human-umbilical-vein-endothelial-cells
#7
Yuya Nakamura, Masahiro Inagaki, Mayumi Tsuji, Toshihiko Gocho, Kazuaki Handa, Hitomi Hasegawa, Akihiko Yura, Tomoko Kawakami, Isao Ohsawa, Yoshikazu Goto, Hiromichi Gotoh, Yuji Kiuchi
BACKGROUND: Because of the potential anti-inflammatory effects, linagliptin, a therapeutic dipeptidyl peptidase-4 inhibitor, is used as an effective drug for diabetic patients for whom inflammation is a prognosis-related factor. We investigated the anti-inflammatory mechanism of linagliptin using seven markers. METHODS: We pretreated human umbilical vein endothelial cells (HUVECs), with linagliptin and lipopolysaccharide (LPS). The cytosolic fractions were evaluated for protein kinase A (PKA), protein kinase B (PKB), protein kinase C (PKC), ratio of reactive oxygen species (ROS) and Cu/Zn superoxide dismutase (SOD), activator protein 1 (AP-1), and adenosine 3',5'-cyclic monophosphate (cAMP)...
2016: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/27679535/predominant-corticospinal-tract-involvement-in-a-late-infant-with-krabbe-disease
#8
Ayumi Yoshimura, Tetsuya Kibe, Kaori Irahara, Norio Sakai, Kenji Yokochi
A case of late-infantile Krabbe disease in a patient who presented with developmental regression and spastic quadriplegia in late infancy is reported. Brain magnetic resonance imaging (MRI) at 11 months of age showed predominant corticospinal tract involvement, which usually appears in adult Krabbe disease. Galactocerebrosidase activity in lymphocytes and skin fibroblasts was very low. Genetic testing revealed compound heterozygous mutations of the galactocerebrosidase (GALC) gene, c.635_646 delinsCTC and c...
2016: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/27478395/a-patient-held-medical-record-integrating-depression-care-into-diabetes-care
#9
Noriko Satoh-Asahara, Hiroto Ito, Tomoyuki Akashi, Hajime Yamakage, Kazuhiko Kotani, Daisuke Nagata, Kazuyuki Nakagome, Mitsuhiko Noda
PURPOSE: Depression is frequently observed in people with diabetes. The purpose of this study is to develop a tool for individuals with diabetes and depression to communicate their comorbid conditions to health-care providers. METHOD: We searched the Internet to review patient-held medical records (PHRs) of patients with diabetes and examine current levels of integration of diabetes and depression care in Japan. RESULTS: Eight sets of PHRs were found for people with diabetes...
2016: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/27257402/perinatal-outcomes-of-monochorionic-diamniotic-twin-pregnancies-uncomplicated-at-28-weeks-of-gestation
#10
Shunji Suzuki
We examined the prevalence of specific perinatal complications of monochorionic-diamniotic twin pregnancies in cases without any abnormal findings until the second trimester of pregnancy. This was a retrospective cohort study performed at a tertiary perinatal center in Tokyo, Japan. There were 88 cases of uncomplicated monochorionic-diamniotic twin pregnancies at 28 weeks of gestation. In five of them (5.7%), there were serious complications associated with placental circulatory imbalance between the twins during the third trimester of pregnancy...
2016: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/27081329/familial-dysalbuminemic-hyperthyroxinemia-in-a-japanese-man-caused-by-a-point-albumin-gene-mutation-r218p
#11
Yoshinori Osaki, Yoshitaka Hayashi, Yoshinori Nakagawa, Katsumi Yoshida, Hiroshi Ozaki, Hiroshi Fukazawa
Familial dysalbuminemic hyperthyroxinemia (FDH) is a familial autosomal dominant disease caused by mutation in the albumin gene that produces a condition of euthyroid hyperthyroxinemia. In patients with FDH, serum-free thyroxine (FT4) and free triiodothyronine (FT3) concentrations as measured by several commercial methods are often falsely increased with normal thyrotropin (TSH). Therefore, several diagnostic steps are needed to differentiate TSH-secreting tumor or generalized resistance to thyroid hormone from FDH...
2016: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/26949348/continuous-glucose-monitoring-in-patients-with-abnormal-glucose-tolerance-during-pregnancy-a-case-series
#12
Mie Tonoike, Miyako Kishimoto, Mayumi Yamamoto, Tetsu Yano, Mitsuhiko Noda
Abnormal glucose tolerance during pregnancy is associated with perinatal complications. We used continuous glucose monitoring (CGM) in pregnant women with glucose intolerance to achieve better glycemic control and to evaluate the maternal glucose fluctuations. We also used CGM in women without glucose intolerance (the control cases). Furthermore, the standard deviation (SD) and mean amplitude of glycemic excursions (MAGE) were calculated for each case. For the control cases, the glucose levels were tightly controlled within a very narrow range; however, the SD and MAGE values in pregnant women with glucose intolerance were relativity high, suggesting postprandial hyperglycemia...
2016: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/26688669/sustained-decrease-of-early-phase-insulin-secretion-in-japanese-women-with-gestational-diabetes-mellitus-who-developed-impaired-glucose-tolerance-and-impaired-fasting-glucose-postpartum
#13
Hiroko Katayama, Daisuke Tachibana, Akihiro Hamuro, Takuya Misugi, Koka Motoyama, Tomoaki Morioka, Shinya Fukumoto, Masanori Emoto, Masaaki Inaba, Masayasu Koyama
OBJECTIVE: The aim of this study was to compare glucose intolerance in the antenatal and the postpartum periods using a 75-g oral glucose tolerance test (OGTT) in the Japanese women with gestational diabetes mellitus (GDM) using a retrospective design. PATIENTS AND METHODS: Data were obtained from 85 Japanese women with GDM who delivered from April 2011 through April 2015 and who underwent an OGTT 6-14 weeks postpartum. The women were divided into two groups based on the results of the postpartum OGTT: one group with normal glucose tolerance (NGT) and the other with impaired glucose tolerance (IGT) as well as impaired fasting glucose (IFG)...
2015: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/26568687/serum-biopterin-and-neopterin-levels-as-predictors-of-empty-follicles
#14
Akihiro Hamuro, Daisuke Tachibana, Takuya Misugi, Hiroko Katayama, Koji Ozaki, Yuji Fujino, Nakamura Yoshihiro, Haruo Shintaku, Masayasu Koyama
OBJECTIVE: This study measured serum and follicular fluid (FF) levels of biopterin, neopterin, vascular endothelial growth factor (VEGF), and macrophage colony-stimulating factor (M-CSF) in patients receiving mild ovarian stimulation for oocyte retrieval. PATIENTS AND METHODS: Infertile patients who underwent ovarian stimulation were divided into the following: Group 1, no oocyte retrieval (n = 12), and Group 2, retrieval of more than four oocytes (n = 13). Median total gonadotropin dose in both groups was 150 IU...
2015: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/26483614/beta-adrenergic-blockade-therapy-for-autonomic-dysfunction-is-less-effective-for-elderly-patients-with-heart-failure-and-reduced-left-ventricular-ejection-fraction
#15
Ken Shimamoto, Masatoshi Kawana
OBJECTIVE: Heart rate variability (HRV) has been reported to be an independent predictor of all-cause and sudden cardiac death in patients with heart failure. In the aging heart, however, both autonomic and cardiac functions appear to be altered. We assessed the relationship between aging and responsiveness of HRV and ventricular remodeling to beta-adrenergic blockade therapy in patients with heart failure and reduced ejection fraction (HFREF). METHODS: Twenty-eight clinically stable patients with chronic heart failure, sinus rhythm, and left ventricular ejection fraction <50% as confirmed by echocardiography were included...
2015: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/26441486/analyzing-the-factors-contributing-to-withdrawal-from-insulin-therapy-following-additional-administration-of-alogliptin-retrospective-study-after-removing-glucotoxicity-with-insulin
#16
Hiromi Hamamoto, Koji Nakanishi, Mitsuhiko Noda
We attempted to examine whether withdrawal from insulin therapy is or is not possible with administration of additional alogliptin and identify the contributing factors. The subjects were 43 adult patients with type 2 diabetes undergoing insulin therapy after admission. After glucotoxicity was removed, 25 mg alogliptin was additionally administered. Insulin was reduced by 15.6 ± 13.0 units (mean ± SD), and 17 patients (39.5%) completely withdrew from insulin therapy. Several factors were compared between the two groups of patients: those who could withdraw from insulin therapy and those who could not...
2015: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/26279637/treatment-of-myasthenia-gravis-in-patients-with-elderly-onset-at-advanced-age
#17
Noriko Nishikawa, Masahiro Nagai, Tomoaki Tsujii, Win T Kyaw, Nachi Tanabe, Hirotaka Iwaki, Hayato Yabe, Rina Ando, Masahiro Nomoto
The number of patients with late-onset myasthenia gravis (MG) among patients ≥50 years has been increasing recently. We encountered three patients who developed elderly-onset MG at a particularly advanced age (≥80 years). All were female and positive for anti-acetylcholine receptor antibodies. About 4 years have passed since MG onset in all three patients and symptoms have been controlled without recurrence using a combination of oral low-dose prednisolone and tacrolimus. As many cases of elderly-onset MG do not require strong immunosuppression, we recommend minimum immunosuppressive treatment to avoid adverse events, particularly in patients at an advanced age of ≥80 years...
2015: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/25922591/successful-prednisolone-therapy-in-elderly-patients-with-severe-forms-of-henoch-sch%C3%A3-nlein-purpura-nephritis
#18
Saiko Kato-Okada, Hiromichi Suzuki, Tsutomu Inoue, Tomohiro Kikuta, Hirokazu Okada
INTRODUCTION: Recently, Henoch-Schönlein purpura (HSP) has been observed in elderly people, although it was believed to be uncommon in these subjects. The increased risks of developing end-stage renal disease (ESRD) in adults in comparison with children were highlighted by different studies; however, limited data are available on the treatment of HSP nephritis in adults. METHODS: Between 2002 and 2008, five elderly Japanese patients (>65 years old) (mean age, 68 years, ranging from 65 to 72) with severe forms of HSP nephritis were entered into a prospective study to evaluate prednisolone therapy on the outcome of nephropathy in terms of clinical symptoms and histopathological changes...
2015: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/25628516/a-case-of-fetal-intestinal-volvulus-without-malrotation-causing-severe-anemia
#19
Tomoko Nakagawa, Daisuke Tachibana, Kohei Kitada, Yasushi Kurihara, Hiroyuki Terada, Masayasu Koyama, Yukari Sakae, Yoshiki Morotomi, Shiho Nomura, Mika Saito
Fetal intestinal volvulus without malrotation is a rare, life-threatening disease. Left untreated, hemorrhage from necrotic bowel tissue will lead to severe fetal anemia and even intrauterine death. We encountered a case of fetal intestinal volvulus causing severe anemia, which was diagnosed postnatally and successfully treated with surgical intervention.
2015: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/25368541/prospective-randomized-trial-on-postoperative-administration-of-diet-containing-eicosapentaenoic-acid-docosahexaenoic-acid-gamma-linolenic-acid-and-antioxidants-in-head-and-neck-cancer-surgery-patients-with-free-flap-reconstruction
#20
Kiyoaki Tsukahara, Ray Motohashi, Hiroki Sato, Minoru Endo, Yuri Ueda, Kazuhiro Nakamura
OBJECTIVES: The purpose of this prospective, randomized study was to evaluate the effects of a diet containing eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), gamma-linolenic acid (GLA), and antioxidants in head and neck cancer surgery patients with free-flap reconstruction. METHODS: In this randomized, prospective study, 62 patients with head and neck cancers were assigned to receive a general control diet (Ensure(®) H; Abbott Japan, Tokyo, Japan) or the study diet (Oxepa(®); Abbott Japan) containing EPA, DHA, GLA, and antioxidants (eg vitamins A, E, and C)...
2014: Japanese Clinical Medicine
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