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Annals of Cardiothoracic Surgery

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https://www.readbyqxmd.com/read/29492396/heart-transplantation
#1
Christopher Harris, Christopher Cao, Beth Croce, Stine Munkholm-Larsen
No abstract text is available yet for this article.
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492395/standard-orthotopic-heart-transplantation
#2
REVIEW
Jérôme G M Jungschleger, Sergey Yu Boldyrev, Vasily I Kaleda, John H Dark
No abstract text is available yet for this article.
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492394/pre-transplant-ventricular-assist-device-explant
#3
REVIEW
Espeed Khoshbin, Stephan Schueler
Explantation of a left ventricular assist device (LVAD) may be challenging even in the most experienced hands. We aim to describe the technique for explantation of an LVAD together with the heart as applicable to all contemporary implantable mechanical assist devices. In order to ensure safe explantation, particular care must be taken at three distinct stages: at the time of LVAD implantation, at pre-transplant assessment and at the time of heart transplantation. The preparation for a safe explantation at LVAD implantation includes positioning the driveline and the outflow graft away from the back of the sternum to ensure protection from injury during re-entry into the chest...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492393/transplantation-in-the-single-ventricle-population
#4
Louise A Kenny, Fabrizio DeRita, Mohamed Nassar, John Dark, Louise Coats, Asif Hasan
The single ventricle patient population comprises the most complex cohort presenting to the cardiac transplant team, in terms of demographics, anatomic substrate, and unique physiology. It is also the most rapidly growing diagnostic group presenting for heart transplantation. In this manuscript, we aim to describe the changing landscape of transplantation in single ventricle conditions through reflection on our own institution's practice and experience, alongside contemporary literature review. Single ventricle patients are heterogeneous in terms of age, anatomic diagnosis and physiology according to surgical stage of repair...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492392/overview-of-adult-congenital-heart-transplants
#5
Roosevelt Bryant, David Morales
Transplantation for adult patients with congenital heart disease (ACHD) is a growing clinical endeavor in the transplant community. Understanding the results and defining potential high-risk patient subsets will allow optimization of patient outcomes. This review summarizes the scope of ACHD transplantation, the mechanisms of late ventricular dysfunction, the ACHD population at risk of developing heart failure, the indications and potential contraindications for transplant, surgical considerations, and post-transplant outcomes...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492391/the-future-of-cardiac-transplantation
#6
Kevin Koomalsingh, Jon A Kobashigawa
The first human-to-human heart transplant was performed 50 years ago in 1967. Heart transplantation has now entered an era of tremendous growth and innovation. The future of heart transplantation is bright with the advent of newer immunosuppressive medications and strategies that may even result in tolerance. Much of this progress in heart transplant medicine is predicated on a better understanding of acute and chronic rejection pathways through basic science studies. The future will also include personalized medicine where genomics and molecular science will dictate customized treatment for optimal outcomes...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492390/donor-selection-in-the-modern-era
#7
Kiran K Khush
The growing disparity between the supply of donor hearts for transplantation and the demand for such organs has led to liberalization of the criteria for donor heart acceptance over the past few decades. The upper age limit and size restrictions for donor heart acceptance continue to be revised and hearts are being routinely used from donors with left ventricular dysfunction, left ventricular hypertrophy (LVH), cocaine use, multiple medical co-morbidities and after cardiopulmonary resuscitation. This article reviews recent data for use of such "expanded criteria" donor hearts and suggests ways to further increase the donor pool, including use of hearts from donors with hepatitis C and after circulatory determination of death...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492389/neonatal-heart-transplantation
#8
Mohan John, Leonard L Bailey
Neonatal heart transplantation was developed and established in the 1980's as a durable modality of therapy for complex-uncorrectable heart disease. Patients transplanted in the neonatal period have experienced unparalleled long-term survival, better than for any other form of solid-organ transplantation. However, the limited availability of neonatal and young infant donors has restricted the indications and applicability of heart transplantation among newborns in the current era. Indications for heart transplantation include congenital heart disease not amenable to other forms of surgical palliation, and cardiomyopathy, including some primary tumors...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492388/how-to-obtain-and-maintain-favorable-results-after-heart-transplantation-keys-to-success
#9
Johan J A Van Cleemput, Tom O M Verbelen, Lucas N L Van Aelst, Filip R L Rega
We compared survival in our heart recipients with survival rates reported by the International Society of Heart and Lung Transplantation (ISHLT) Registry. As recipient and donor characteristics are changing over time, we studied four different eras. In order to differentiate between short- and long-term survival, we analyzed both overall survival and survival at one year. Obviously, this exercise is only relevant when baseline donor and recipient characteristics are comparable, as these differences may affect the outcome in opposite directions...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492387/the-cardioprotective-effect-of-interleukin-11-against-ischemia-reperfusion-injury-in-a-heart-donor-model
#10
Yusaku Tamura, Hiroki Kohno, Tomomi Mohri, Yasushi Fujio, Goro Matsumiya
Background: Previously, we have demonstrated the cardioprotective effect of interleukin (IL)-11 in animal models of acute coronary syndrome. In this study, we sought to evaluate its cardioprotective potential during prolonged hypothermic global ischemia and subsequent reperfusion using a rat heart donor model. Methods: IL-11 was administered intravenously 10 minutes before harvesting the rat heart. The hearts were preserved in cold (4 °C) Krebs-Henseleit buffer for 6 hours, and then attached to a Langendorff perfusion apparatus and reperfused with an oxygenated Krebs-Henseleit solution containing IL-11...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492386/role-of-paediatric-assist-device-in-bridge-to-transplant
#11
Roland Hetzer, Mariano Francisco Del Maria Javier, Eva Maria Delmo Walter
Background: While heart transplantation has gained recognition as the gold standard therapy for advanced heart failure, the scarcity of donor organs has become an important concern. The evolution of surgical alternatives such as ventricular assist devices (VADs), allow for recovery of the myocardium and ensure patient survival until heart transplantation becomes possible. This report elaborates the role of VADs as a bridge to heart transplantation in infants and children (≤18 years old) with end-stage heart failure...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492385/heart-transplantation-from-donation-after-circulatory-determined-death
#12
REVIEW
Aravinda Page, Simon Messer, Stephen R Large
Fifty years since the first successful human heart transplant from a non-heart beating donor, this concept of heart transplantation from donation after circulatory determined death (DCD) promises to be one of the most exciting developments in heart transplantation. Heart transplantation has established itself as the best therapeutic option for patients with end-stage heart failure, with the opportunity to provide these patients with a near-normal quality of life. However, this treatment is severely limited by the availability of suitable donor hearts...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492384/current-approaches-in-retrieval-and-heart-preservation
#13
REVIEW
Maria Monteagudo Vela, Diana García Sáez, Andre R Simon
Fifty years after the first successful heart transplantation, despite multiple advances in the treatment of advanced acute and chronic heart failure, there is still no equivalent to heart transplantation as a long-term treatment for end-stage heart failure. Transplantation is, however, limited by the scarcity and quality of heart allografts. Donors are nowadays significantly older, particularly in European countries, and traumatic head injury as the cause of death has been replaced by intracerebral hemorrhage or hypoxic brain damage in the majority of cases...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492383/current-indications-for-transplantation-stratification-of-severe-heart-failure-and-shared-decision-making
#14
REVIEW
Darko Vucicevic, Lily Honoris, Federica Raia, Mario Deng
Heart failure (HF) is a complex clinical syndrome that results from structural or functional cardiovascular disorders causing a mismatch between demand and supply of oxygenated blood and consecutive failure of the body's organs. For those patients with stage D HF, advanced therapies, such as mechanical circulatory support (MCS) or heart transplantation (HTx), are potentially life-saving options. The role of risk stratification of patients with stage D HF in a value-based healthcare framework is to predict which subset might benefit from advanced HF (AdHF) therapies, to improve outcomes related to the individual patient including mortality, morbidity and patient experience as well as to optimize health care delivery system outcomes such as cost-effectiveness...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492382/current-state-of-pediatric-cardiac-transplantation
#15
REVIEW
Anne I Dipchand
Pediatric heart transplantation is standard of care for children with end-stage heart failure. The diverse age range, diagnoses, and practice variations continue to challenge the development of evidence-based practices and new technologies. Outcomes in the most recent era are excellent, especially with the more widespread use of ventricular assist devices (VADs). Waitlist mortality remains high and knowledge of risk factors for death while waiting and following transplantation contributes to decision-making around transplant candidacy and timing of listing...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492381/percutaneous-coronary-intervention-versus-coronary-artery-bypass-grafting-in-heart-transplant-recipients-with-coronary-allograft-vasculopathy-a-systematic-review-and-meta-analysis-of-1-520-patients
#16
REVIEW
Jessica G Y Luc, Jae Hwan Choi, Syed-Saif Abbas Rizvi, Kevin Phan, Ester Moncho Escrivà, Sinal Patel, Gordon R Reeves, Andrew J Boyle, John W Entwistle, Rohinton J Morris, H Todd Massey, Vakhtang Tchantchaleishvili
Background: Transplant coronary artery vasculopathy (TCAV) is the major cause of late allograft failure and death in heart transplant recipients. The aim of this systematic review was to examine the outcomes of percutaneous coronary interventions (PCIs) as compared to coronary artery bypass grafting (CABG) surgery in the management of TCAV. Our secondary objective was to compare the use and outcomes of drug eluting stents (DES) as compared to bare metal stents (BMS) in this patient population...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492380/outcomes-and-survival-following-heart-retransplantation-for-cardiac-allograft-failure-a-systematic-review-and-meta-analysis
#17
REVIEW
Syed-Saif Abbas Rizvi, Jessica G Y Luc, Jae Hwan Choi, Kevin Phan, Ester Moncho Escrivà, Sinal Patel, H Todd Massey, Vakhtang Tchantchaleishvili
Background: Long-term efficacy of heart retransplantation (RTx) for end-stage cardiac allograft failure remains unclear given the limited worldwide experience and is an important question to elucidate given the shortage of donor organs. The aim of this systematic review was to examine the outcomes of RTx in patients with cardiac allograft failure. Methods: Electronic search was performed to identify all studies in the English literature assessing RTx for cardiac allograft failure...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492379/heart-transplantation-versus-left-ventricular-assist-devices-as-destination-therapy-or-bridge-to-transplantation-for-1-year-mortality-a-systematic-review-and-meta-analysis
#18
REVIEW
Christina A Theochari, George Michalopoulos, Evangelos K Oikonomou, Stefanos Giannopoulos, Ilias P Doulamis, M Alvarez Villela, Damianos G Kokkinidis
Background: The optimal treatment for advanced heart failure (HF) patients with regards to mortality remains unknown. Heart transplantation (HTx) and left ventricular assist devices (LVAD) used either as a bridge to transplant (BTT) or destination therapy (DT) have been compared in a number of studies, without definite conclusions with regards to mortality benefit. We sought to systematically review the pertinent literature and perform a meta-analysis of all the available studies presenting head-to-head comparisons between HTx and LVAD BTT or LVAD DT for late (>6 months) all-cause mortality...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492378/back-to-the-future
#19
John H Dark, Asif Hasan
No abstract text is available yet for this article.
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29492377/guest-editor-introduction
#20
Ashleigh Xie, Tristan D Yan
No abstract text is available yet for this article.
January 2018: Annals of Cardiothoracic Surgery
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