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Annals of Cardiothoracic Surgery

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https://www.readbyqxmd.com/read/29270387/bicuspid-aortic-valve
#1
Christopher Harris, Beth Croce, Stine Munkholm-Larsen
No abstract text is available yet for this article.
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270386/two-stage-elephant-trunk-approach-for-open-management-of-distal-aortic-arch-and-descending-aortic-pathology-in-patients-with-marfan-syndrome
#2
REVIEW
Camilo A Velasquez, Mohammad A Zafar, Ayman Saeyeldin, Syed Usman Bin Mahmood, Adam J Brownstein, Young Erben, Bulat A Ziganshin, John A Elefteriades
No abstract text is available yet for this article.
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270385/thoracoabdominal-aortic-aneurysm-repair-in-marfan-syndrome-how-we-do-it
#3
REVIEW
Rana O Afifi, Akiko Tanaka, Ibrahim Yazji, Hazim J Safi, Anthony L Estrera
No abstract text is available yet for this article.
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270384/aortic-valve-repair-in-patients-with-marfan-syndrome-the-brussels-approach
#4
REVIEW
Stefano Mastrobuoni, Saadallah Tamer, Emiliano Navarra, Laurent de Kerchove, Gebrine El Khoury
No abstract text is available yet for this article.
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270383/valve-sparing-aortic-root-replacement-in-patients-with-marfan-syndrome-the-homburg-experience
#5
REVIEW
Ulrich Schneider, Tristan Ehrlich, Irem Karliova, Christian Giebels, Hans-Joachim Schäfers
No abstract text is available yet for this article.
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270382/valve-sparing-versus-composite-root-replacement-procedures-in-patients-with-marfan-syndrome
#6
REVIEW
Joseph S Coselli, Scott A Weldon, Ourania Preventza, Kim I de la Cruz, Scott A LeMaire
No abstract text is available yet for this article.
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270381/aortic-valve-sparing-root-surgery-for-marfan-syndrome
#7
REVIEW
George Matalanis, Nisal K Perera
Aortic valve sparing root surgery (AVSRS) is a safe and durable alternative for patients with dilated roots or pure aortic regurgitation (AR), which avoids the risks of anticoagulation or valvular degeneration with prosthetic valves. Notwithstanding the theoretical challenges of greater tissue fragility in Marfan syndrome (MFS), AVSRS has been demonstrated to have equal outcomes in this condition as it does in those without MFS. The benefits of retaining the native aortic valve in this generally younger age group extend beyond those of avoiding the inconvenience and complications of prolonged exposure to anticoagulants and include ease of management for future aortic, cardiac and non-cardiac procedures which are the norm for these patients...
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270380/endovascular-surgery-in-marfan-syndrome-con
#8
Nicholas T Kouchoukos
The frequency of endovascular stent grafting procedures to treat various conditions of the thoracic aorta has increased dramatically over the past three decades. Stent grafting has been applied on a limited basis in patients with Marfan syndrome and other connective tissue disorders, despite recommendations from current guidelines and expert consensus statements against its use in this setting. A review of publications reporting outcomes after stent grafting of the descending thoracic aorta in Marfan patients with acute or chronic aortic dissection indicates that these procedures can be accomplished with rates of early mortality, stroke and spinal cord ischemic injury that are comparable to those observed in patients who do not have Marfan syndrome...
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270379/endovascular-therapy-in-marfan-syndrome-pro
#9
Bruce Tjaden, Ali Azizzadeh
Marfan syndrome (MFS) is an inherited connective tissue disorder that is associated with arterial fragility and aortic pathologies. The endovascular treatment of patients with MFS is controversial. Published series suggest that while endovascular intervention can be carried out with a low rate of immediate morbidity and mortality, midterm follow up demonstrates sizeable numbers of complications. However, in certain situations-such as rupture, reintervention for patch aneurysms, and elective interventions in which the landing zone is within a previously placed graft-endovascular interventions are appropriate...
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270378/re-interventions-on-the-thoracic-and-thoracoabdominal-aorta-in-patients-with-marfan-syndrome
#10
Florian S Schoenhoff, Thierry P Carrel
The advent of multi-gene panel genetic testing and the discovery of new syndromic and non-syndromic forms of connective tissue disorders have established thoracic aortic aneurysms as a genetically mediated disease. Surgical results in patients with Marfan syndrome (MFS) provide an important benchmark for this patient population. Prophylactic aortic root surgery prevents acute dissection and has contributed to the improved survival of MFS patients. In the majority of patients, re-interventions are driven by a history of dissection...
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270377/medical-management-of-aortic-disease-in-marfan-syndrome
#11
Syed Usman Bin Mahmood, Camilo A Velasquez, Mohammad A Zafar, Ayman A Saeyeldin, Adam J Brownstein, Bulat A Ziganshin, John A Elefteriades, Sandip K Mukherjee
Marfan syndrome (MFS) is a hereditary disorder with numerous pathophysiological effects, some specifically creating elastic dysfunction in cardiovascular organs. Aortic dilatation, dissection and rupture are major concerns in the management of MFS patients. Predilection to form aneurysms is an indication for prophylactic medical management of thoracic aortic aneurysm disease in these patients. The current guidelines describe β-blockers as the standard of care with angiotensin receptor blockers (ARBs) emerging as an equal, if not better alternative...
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270376/pregnancy-and-marfan-syndrome
#12
Sorel Goland, Uri Elkayam
Pregnancy in women with Marfan syndrome (MFS) presents challenges to the clinician and the patient due to the increased incidence of maternal complications and involvement of the fetus, and deserves special consideration. The leading cause of morbidity and mortality in MFS is aortic dissection. This article presents an extensive review of available clinical information and provides recommendations for the management of patients with MFS during pregnancy.
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270375/aortic-dissection-in-patients-with-marfan-syndrome-based-on-the-irad-data
#13
Hector W L de Beaufort, Santi Trimarchi, Amit Korach, Marco Di Eusanio, Dan Gilon, Daniel G Montgomery, Arturo Evangelista, Alan C Braverman, Edward P Chen, Eric M Isselbacher, Thomas G Gleason, Carlo De Vincentiis, Thoralf M Sundt, Himanshu J Patel, Kim A Eagle
Between January 1996 and May 2017, the International Registry on Acute Aortic Dissections has collected information on a total of 6,424 consecutive patients with acute aortic dissection, including 258 individuals with a diagnosis of Marfan syndrome. Patients with Marfan syndrome presented at a significantly younger age compared to patients without Marfan syndrome (38.2±13.2 vs. 63.0±14.0 years; P<0.001) and in general had fewer comorbidities, although they more frequently had a known aortic aneurysm and history of prior cardiac surgery...
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270374/natural-history-of-aortic-root-aneurysms-in-marfan-syndrome
#14
Ayman Saeyeldin, Mohammad A Zafar, Camilo A Velasquez, Kevan Ip, Anton Gryaznov, Adam J Brownstein, Yupeng Li, John A Rizzo, Young Erben, Bulat A Ziganshin, John A Elefteriades
Background: Cardiovascular complications account for a significant proportion of the shortened lifespan of Marfan syndrome (MFS) patients, with aortic dissection being the most dreadful complication. The aortic root dilates initially in MFS patients, and given its important hemodynamic role, this can lead to aortic regurgitation and poses a substantial risk of aortic dissection. This study seeks to evaluate the natural history of aortic root aneurysms in MFS patients, with a focus on growth rates and correlation of root diameter with the risk of developing aortic complications...
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270373/biomechanical-properties-of-the-thoracic-aorta-in-marfan-patients
#15
Fatiesa Sulejmani, Anastassia Pokutta-Paskaleva, Bulat Ziganshin, Bradley Leshnower, Glen Iannucci, John Elefteriades, Wei Sun
Background: Marfan syndrome (MFS), a genetic disorder of the connective tissue, has been strongly linked to dilation of the thoracic aorta, among other cardiovascular complications. As a result, MFS patients frequently suffer from aortic dissection and rupture, contributing to the high rate of mortality and morbidity among MFS patients. Despite the significant effort devoted to the investigation of mechanical and structural properties of aneurysmal tissue, studies on Marfan aneurysmal biomechanics are scarce...
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270372/non-cardiac-manifestations-of-marfan-syndrome
#16
REVIEW
Anne H Child
Because of the widespread distribution of fibrillin 1 in the body, Marfan syndrome (MFS) affects virtually every system. The expression of this single dominantly inherited gene is variable within a family, and between families. There is some genotype-phenotype correlation which is helpful in guiding long-term prognosis, and management. In general gene mutations have been reported in clusters, with those having mainly ocular manifestations occurring in exons 1 to 15 of this 65-exon gene; those causing cardiac problems often involving cysteine replacement in a calcium binding EGF-like sequence; the most severe mutations occurring in exons 25-32, causing neonatal MFS diagnosed at birth, and severe enough to cause death frequently before the age of 2...
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270371/etiology-and-pathogenesis-of-the-marfan-syndrome-current-understanding
#17
REVIEW
Reed E Pyeritz
Much has changed regarding Marfan syndrome (MFS) over the past few decades. Once described solely as a heritable disorder of connective tissue, MFS is now one of a number of conditions recognized to be a disorder of abnormal signalling in the TGF-β pathway. The cardinal features of MFS, once encompassed by the ocular, skeletal and cardiovascular systems, are now known to encompass many more organ systems, especially as people with MFS grow older. They are growing older by several decades compared to the 1970's because of profound improvements in diagnosis and management of the cardiovascular features, especially dilatation of the aortic root...
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270370/differences-in-manifestations-of-marfan-syndrome-ehlers-danlos-syndrome-and-loeys-dietz-syndrome
#18
REVIEW
Josephina A N Meester, Aline Verstraeten, Dorien Schepers, Maaike Alaerts, Lut Van Laer, Bart L Loeys
Many different heritable connective tissue disorders (HCTD) have been described over the past decades. These syndromes often affect the connective tissue of various organ systems, including heart, blood vessels, skin, joints, bone, eyes, and lungs. The discovery of these HCTD was followed by the identification of mutations in a wide range of genes encoding structural proteins, modifying enzymes, or components of the TGFβ-signaling pathway. Three typical examples of HCTD are Marfan syndrome (MFS), Ehlers-Danlos syndrome (EDS), and Loeys-Dietz syndrome (LDS)...
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270369/systematic-review-and-meta-analysis-of-surgical-outcomes-in-marfan-patients-undergoing-aortic-root-surgery-by-composite-valve-graft-or-valve-sparing-root-replacement
#19
REVIEW
Campbell D Flynn, David H Tian, Ashley Wilson-Smith, Tirone David, George Matalanis, Martin Misfeld, Stefano Mastrobuoni, Gebrine El Khoury, Tristan D Yan
Background: A major, life-limiting feature of Marfan syndrome (MFS) is the presence of aneurysmal disease. Cardiovascular intervention has dramatically improved the life expectancy of Marfan patients. Traditionally, the management of aortic root disease has been undertaken with composite-valve graft replacing the aortic valve and proximal aorta; more recently, valve sparing procedures have been developed to avoid the need for anticoagulation. This meta-analysis assesses the important surgical outcomes of the two surgical techniques...
November 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29270368/tell-me-something-i-don-t-know
#20
John A Elefteriades, Bulat A Ziganshin
No abstract text is available yet for this article.
November 2017: Annals of Cardiothoracic Surgery
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