journal
MENU ▼
Read by QxMD icon Read
search

Endocrine Connections

journal
https://www.readbyqxmd.com/read/29764904/aberrant-mrp14-expression-in-thyroid-follicular-cells-mediates-chemokine-secretion
#1
Xuan Luo, Tingting Zheng, Chaoming Mao, Xin Dong, Xiao Mou, Chengcheng Xu, Qingyan Lu, Baocui Liu, Shengjun Wang, Yichuan Xiao
Myeloid-related protein 14 (MRP14) is responsible for inflammatory reactions. However, the correlation between MRP14 and Hashimoto's thyroiditis (HT) is still not clear. In this study, we examined the status of MRP14 in thyroid tissues and sera of HT patients and explored the mechanism of IL-1β-mediated regulation of MRP14 expression, as well as the effects of MRP14 on pro-inflammatory chemokine secretion in thyroid follicular cells (TFCs), to elucidate the role of MRP14 in HT development. Our results showed dramatically increased MRP14 expression in thyroid tissues and sera from HT patients...
May 15, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29764903/vitamin-d-supplementation-does-not-improve-cvd-risk-factors-in-vitamin-d-insufficient-subjects
#2
Julia Magdalena Kubiak, Per Medbøe Thorsby, Elena Kamycheva, Rolf Jorde
OBJECTIVE: Low serum 25(OH)D levels are associated with cardiovascular disease (CVD) and some of its risk factors. However, in interventional studies the effects of vitamin D supplementation have been uncertain, possibly due to inclusion of vitamin D sufficient subjects. Our aim was therefore to examine effects of vitamin D supplementation on CVD risk factors in vitamin D insufficient subjects. DESIGN: Double-blinded randomized controlled trial. METHODS: A four months interventional study with high dose vitamin D (100 000 IU loading dose, followed by 20 000 IU/week) or placebo with measurements of blood pressure, lipids (total-, LDL- and HDL-cholesterol, triglycerides, apolipoproteins A1 and B), and glucose metabolism parameters (blood glucose, HbA1c, sRAGE, insulin, C-peptide, and HOMA-IR)...
May 15, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29760189/incidence-and-prevalence-of-sporadic-and-hereditary-mtc-in-denmark-1960-2014-a-nationwide-study
#3
Jes Sloth Mathiesen, Jens Peter Kroustrup, Peter Vestergaard, Kirstine Stochholm, Per Løgstrup Poulsen, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Sten Schytte, Stefano Christian Londero, Henrik Baymler Pedersen, Christoffer Holst Hahn, Bjarki Ditlev Djurhuus, Jens Bentzen, Sören Möller, Mette Gaustadnes, Maria Rossing, Finn Cilius Nielsen, Kim Brixen, Anja Lisbeth Frederiksen, Christian Godballe
Recent studies have shown a significant increase in the temporal trend of medullary thyroid carcinoma (MTC) incidence. However, it remains unknown to which extent sporadic medullary thyroid carcinoma (SMTC) and hereditary MTC (HMTC) affects the MTC incidence over time. We conducted a nationwide retrospective study using previously described RET and MTC cohorts combined with review of medical records, pedigree comparison and relevant nationwide registries. The study included 474 MTC patients diagnosed in Denmark between 1960 and 2014...
May 14, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29760188/depression-in-type-1-diabetes-was-associated-with-high-levels-of-circulating-galectin-3
#4
Eva O Melin, Jonatan Dereke, Maria Thunander, Magnus Hillman
OBJECTIVE: Neuroinflammatory responses are implicated in depression. The aim was to explore whether depression in patients with type 1 diabetes (T1D) was associated with high circulating galectin-3, controlling for metabolic variables, s-creatinine, life style factors, medication, and cardiovascular complications. DESIGN: Cross-sectional. METHODS: Participants were T1D patients (n=283, 56% men, age 18-59 years, diabetes duration ≥1 year)...
May 14, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29748174/pituitary-dysfunction-and-association-with-fatigue-in-stroke-and-other-acute-brain-injury
#5
Heleen A Booij, Wietse D C Gaykema, Kamiel A J Kuijpers, Marie-José M Pouwels, Heleen M den Hertog
BACKGROUND: Poststroke fatigue (PSF) is a highly prevalent and debilitating condition. However, the etiology remains incompletely understood. Literature suggests the co-prevalence of pituitary dysfunction (PD) with stroke, and the question raises whether this could be a contributing factor to the development of PSF. This study reviews the prevalence of PD after stroke and other acquired brain injuries and its association with fatigue. SUMMARY: We performed a bibliographic literature search of MEDLINE and Embase databases for English language studies on PD in adult patients with stroke, traumatic brain injury (TBI) or aneurysmatic subarachnoid hemorrhage (aSAH)...
May 10, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29724795/the-growth-hormone-insulin-like-growth-factor-i-axis-in-the-diagnosis-and-treatment-of-growth-disorders
#6
Werner Blum, Abdullah Alherbish, Afaf Alsagheir, Ahmed El Awwa, Walid Kaplan, Ekaterina Koledova, Martin O Savage
The growth hormone (GH)-insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a good knowledge of GH secretion and assessment, understanding and use of measurements of the components of the IGF system are less current in clinical practice. The physiological function of this axis is to increase the anabolic cellular processes of protein synthesis and mitosis, and reduction of apoptosis, with each being regulated in the appropriate target tissue...
May 3, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29724794/prognostic-value-of-chromogranin-a-in-patients-with-get-nen-in-the-pancreas-and-the-small-intestine
#7
Malgorzata Fuksiewicz, Maria Kowalska, Agnieska Kolasinska-Cwikla, Jaroslaw B Cwikla, Lukasz Sawicki, Katarzyna Roszkowska-Purska, Joanna Drygiel, Beata Kotowicz
The aim of this study was to evaluate the clinical usefulness of the chromogranin A determination in patients with NENs of the digestive system and to analyse the association between concentration of the marker and PFS and OS. Serum concentrations of CgA were determined before the treatment in 131 patients with NENs, including patients with tumours located in the pancreas, the small intestine, caecum, appendix and in the colon. No significant associations were identified in CgA concentrations between the control group and patients with NENs in appendix and colon...
May 3, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29720511/prednisolone-is-associated-with-a-worse-bone-mineral-density-in-primary-adrenal-insufficiency
#8
Kathrin Frey, Tina Kienitz, Julia Schulz, Manfred Ventz, Kathrin Zopf, Marcus Quinkler
CONTEXT: Patients with primary adrenal insufficiency (PAI) or congenital adrenal hyperplasia (CAH) receive life-long glucocorticoid (GC) therapy. Daily GC doses are often above the physiological cortisol production rate and can cause long-term morbidities such as osteoporosis. No prospective trial has investigated long-term effect of different GC-therapies on bone mineral density (BMD) in those patients. OBJECTIVES: To determine if patients on hydrocortisone (HC) or prednisolone show changes in BMD after follow-up of 5...
May 2, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29712721/comparative-population-based-analysis-of-pituitary-incidentalomas-vs-clinically-manifesting-sellar-masses
#9
Nadine Marie Vaninetti, David B Clarke, Deborah A Zwicker, Churn-Ern Yip, Barna Tugwell, Steve Doucette, Chris Theriault, Khaled Aldahmani, Syed Ali Imran
PURPOSE: Sellar masses may present either with clinical manifestations of mass effect/hormonal dysfunction (CMSM) or incidentally on imaging (PI). This novel population-based study compares these two entities. METHODS: Retrospective analysis of all patients within a provincial pituitary registry between January 2006 and June 2014. RESULTS: 903 patients were included (681 CMSM, 222 PI). CMSM mainly presented with secondary hormone deficiencies (SHD) or stalk compression (29...
April 30, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29712720/metabolic-disorders-during-pregnancy-and-postpartum-cardiometabolic-risk
#10
Angelo Maria Patti, Kalliopi Pafili, Nikolaos Papanas, Manfredi Rizzo
Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter lead to silent or clinically evident cardiovascular (CV) events. Insulin resistance and central adiposity are of crucial importance in the development of metabolic syndrome and they appear to correlate with CV risk factors, including hypertension and atherogenic dyslipidaemia...
April 30, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29700099/effect-of-a549-neuroendocrine-differentiation-on-cytotoxic-immune-response
#11
Irasema Mendieta, Rosa-Elvira Nunez-Anita, Gilberto Pérez-Sánchez, Lenin Pavon, Alfredo Rodríguez-Cruz, Guadalupe Garcia-Alcocer, Laura Cristina Berumen
The present study was designed to determine the effects of factors secreted by the lung adenocarcinoma cell line with the neuroendocrine phenotype, A549NED, on cytotoxic T lymphocytes (CTL) activity in vitro. A perspective that integrates the nervous, endocrine and immune system in cancer research is essential to understand the complexity of dynamic interactions in tumours. Extensive clinical research suggests that neuroendocrine differentiation (NED) is correlated with worse patient outcomes; however, little is known regarding the effects of neuroendocrine factors on the communication between the immune system and neoplastic cells...
April 26, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29700098/high-prevalence-of-iodine-deficiency-in-pregnant-women-living-in-adequate-iodine-area
#12
Veronica Carneiro Borges Mioto, Ana Carolina Castro Nassif Gomes Monteiro, Rosalinda Y A Camargo, Andreia Rodrigues Borel, Regina Maria Catarino, Sergio Kobayashi, Maria Cristina Chammas, Suemi Marui
INTRODUCTION: Iodine deficiency during pregnancy is associated with obstetrical and neonatal adverse outcomes. Serum thyroglobulin (sTg) and thyroid volume (TV) are optional tools to urinary iodine concentration (UIC) for defining iodine status. This cross sectional study aims to evaluate the iodine status of pregnant women living in iodine-adequate area by spot UIC and correlation with sTg, TV and thyroid function. METHODS: 273 pregnant women were evaluated at three trimesters...
April 26, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29700097/prostaglandin-e2-receptor-3-ep3-signaling-is-induced-in-placentas-with-unexplained-recurrent-pregnancy-losses-urpl
#13
Yao Ye, Aurelia Vattai, Nina Ditsch, Christina Kuhn, Martina Rahmeh, Sven Mahner, Myriam Ripphahn, Roland Immler, Markus Sperandio, Udo Jeschke, Viktoria von Schoenfeldt
Although an inflammatory microenvironment is required for successful implantation, an inflammatory overreaction is one of the causes of unexplained recurrent pregnancy losses (uRPL). Prostaglandin E2 (PGE2) plays a pivotal role in regulating immune balance during early pregnancy and it can stimulate inflammatory reactions via EP3. However, the role of PGE2 receptor signaling in the uRPL remains unknown. We aimed to investigate whether prostaglandin E2 receptor 3 (EP3) signaling is involved in the mechanism of uRPL...
April 26, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29692348/effects-of-insulin-and-analogues-on-carcinogen-induced-mammary-tumours-in-high-fat-fed-rats
#14
Yusaku Mori, Eunhyoung Ko, Rudolf Furrer, Linda C Qu, Stuart C Wiber, George I Fantus, Mario Thevis, Alan Medline, Adria Giacca
It is not fully clarified whether insulin glargine, an analogue with a high affinity for insulin-like growth factor 1 receptor (IGF-1R), increases the risk for cancers that abundantly express IGF-1R such as breast cancer or some types of breast cancer. To gain insight into this issue, female Sprague-Dawley rats fed a high-fat diet were given the carcinogen N-Methyl-N-nitrosourea and randomly assigned to vehicle (control), NPH (unmodified human insulin), glargine, or detemir (n=30 per treatment). Insulins were given subcutaneously (15 U kg-1 day-1) 5 days a week...
April 24, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29686031/dopamine-synthesis-and-dopamine-receptor-expression-are-disturbed-in-recurrent-miscarriages
#15
Michael Gratz, Stavroula Stavrou, Christina Kuhn, Simone Hofmann, Kerstin Hermelink, Helene Heidegger, Stefan Hutter, Doris Mayr, Sven Mahner, Udo Jeschke, Aurelia Vattai
OBJECTIVES: L-dopa-decarboxylase (DDC) is responsible for the synthesis of dopamine. Dopamine, which binds to the D2-dopamine receptor (D2R), plays an important role in the maintenance of pregnancy. Aim of our study was the analysis of DDC and D2R expression in placentas of spontaneous (SM) and recurrent miscarriages (RM) in comparison to healthy controls. METHODS: Patients with SM (n=15) and RM (n=15) were compared with patients from healthy pregnancies (n=15) (pregnancy weeks 7-13 each)...
April 23, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29669805/glucocorticoid-induced-diabetes-in-patients-with-metastatic-spinal-cord-compression
#16
Helga Holm Schultz, Svend Aage Engelholm, Eva Harder Brix, Ulrik Pedersen-Bjergaard, Peter Lommer Kristensen
BACKGROUND: The risk of developing diabetes mellitus (DM) during treatment with high dose glucocorticoids is unknown and monitoring of glucose is random in many settings. OBJECTIVE: To determine incidence of and risk factors for induction of DM during high dose glucocorticoid therapy of metastatic spinal cord compression in patients referred to radiotherapy. Furthermore, to describe the time course of development of DM. SUBJECTS AND METHODS: 140 patients were recruited (131 were included in the analysis) with metastatic spinal cord compression receiving high dose glucocorticoid, ≥100 mg prednisolone per day were included in a prospective, observational cohort study...
April 18, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29669804/subclinical-hypothyroidism-in-pregnant-rats-impaired-learning-and-memory-in-offspring-by-promoting-p75ntr-signaling
#17
Fan Zhang, Jian Chen, Xinyue Lin, Shiqiao Peng, Xiaohui Yu, Zhongyan Shan, Weiping Teng
OBJECTIVE: Maternal hypothyroidism during pregnancy can affect the neurodevelopment of their offspring. This study aimed to investigate the effects of maternal subclinical hypothyroidism (SCH) on spatial learning and memory, and its relationship with the apoptotic factors in cerebral cortex of the offspring. METHODS: Female adult Wistar rats were randomly divided into three groups (n=15 per group): control (CON) group, SCH group and overt hypothyroidism (OH) group...
April 18, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29669803/growth-hormone-in-combination-with-leuprorelin-in-pubertal-children-with-idiopathic-short-stature
#18
Imane Benabbad, Myriam Rosilio, Maithe Tauber, Emmanuel Paris, Anne Fjellestad-Paulsen, Lovisa Berggren, Hiren Patel, Jean-Claude Carel
OBJECTIVE: There is a scarcity of data from randomised controlled trials on the association of growth hormone (GH) with gonadotrophin-releasing hormone (GnRH) agonists in idiopathic short stature (ISS), although this off-label use is common. We aimed to test whether delaying pubertal progression could increase near-adult height (NAH) in GH-treated patients with ISS. METHODS: Patients with ISS at puberty onset were randomised to GH with leuprorelin (combination, n=46) or GH alone (n=45)...
April 18, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29669802/duodenal-l-cell-density-correlates-with-features-of-metabolic-syndrome-and-plasma-metabolites
#19
Annieke C G van Baar, Andrei Prodan, Camilla D Wahlgren, Steen S Poulsen, Filip K Knop, Albert K Groen, Jacques J Bergman, Max Nieuwdorp, Evgeni Levin
Enteroendocrine cells are essential for regulation of glucose metabolism but it is unknown whether they are associated with clinical features of metabolic syndrome and fasting plasma metabolites. Objective We aimed to identify fasting plasma metabolites that associate with duodenal L cell, K cell and delta cell densities in subjects with metabolic syndrome with ranging levels of insulin resistance. Research Design and Methods In this cross-sectional study, we evaluated L, K and delta cell density in duodenal biopsies from treatment naïve males with metabolic syndrome using machine-learning methodology...
April 18, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29666171/comparisons-of-the-oxidative-stress-biomarkers-level-in-gdm-and-non-gdm-among-thai-population-cohort-study
#20
Hathairat Rueangdetnarong, Rattanaporn Sekararithi, Thidarat Jaiwongkam, Sirinart Kumfu, Nipon Chattipakorn, Theera Tongsong, Phudit Jatavan
OBJECTIVE: The primary objective of this study was to compare the levels of oxidative stress biomarkers between pregnancies with GDM and normoglycemic pregnancies. METHODS: A prospective study was conducted on pregnant women at average risk for GDM. The participants were confirmed by 100 g, 3-hour OGTT and categorized into the Control (non-GDM) and GDM groups. All participants were collected for maternal blood at GA 24-28 weeks and early labor and fetal cord blood for measurements of 8-Isoprostane (oxidative stress maker), TNF-α (inflammatory marker) and IL-10 (anti-inflammatory marker) and were followed-up for maternal and neonatal outcomes...
April 17, 2018: Endocrine Connections
journal
journal
47734
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"