journal
MENU ▼
Read by QxMD icon Read
search

Endocrine Connections

journal
https://www.readbyqxmd.com/read/28432082/effect-of-oral-contraceptives-and-or-metformin-on-glp-1-secretion-and-reactive-hypoglycemia-in-pcos
#1
Dorte Glintborg, Hanne Mumm, Jens Juul Holst, Marianne Andersen
CONTEXT: Insulin resistance in polycystic ovary syndrome (PCOS) may increase the risk of reactive hypoglycaemia (RH) and decrease glucagon-like peptide-1 (GLP-1) secretion. The possible effects of treatment with oral contraceptives (OCP) and/or metformin on GLP-1 secretion and risk of RH in PCOS is undetermined. SETTING: Outpatient clinic. PATIENTS AND INTERVENTIONS: Randomized, controlled clinical trial. Ninety women with PCOS were randomized to 12 month treatment with OCP (150 mg desogestrel+30 microgram ethinylestradiol), metformin (2 g/day), or metformin +OCP...
April 21, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28432081/glucose-tolerance-and-insulin-responsiveness-in-gitelman-syndrome-patients
#2
Tao Yuan, Lanping Jiang, Chen Chen, Xiaoyan Peng, Min Nie, Xuemei Li, Xiaoping Xing, Xuewang Li, Limeng Chen
Objective Impaired glucose metabolism and insulin sensitivity have been reported in patients with Gitelman syndrome (GS), but insulin secretion and the related mechanisms are not well understood. Design and Methods The serum glucose levels, insulin secretion and insulin sensitivity were evaluated in patients with GS (n=28), patients with type 2 diabetes mellitus (DM) and healthy individuals (n=20 in both groups) using an oral glucose tolerance test. Serum and urine sodium, potassium and creatinine levels were measured at 0, 30, 60, 120 and 180 min after an oral glucose load was administered...
April 21, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28420718/sex-bmi-and-age-differences-in-metabolic-syndrome-the-dutch-lifelines-cohort-study
#3
Sandra Nicole Slagter, Robert P van Waateringe, André P van Beek, Melanie M van der Klauw, Bruce H R Wolffenbuttel, Jana V van Vliet-Ostaptchouk
INTRODUCTION: To evaluate the prevalence of metabolic syndrome (MetS) and its individual components within sex-, body mass index (BMI)- and age combined clusters. In addition, we used the diagnostic age-adjusted blood pressure thresholds to demonstrate the effect on the prevalence of MetS and elevated blood pressure. SUBJECTS AND METHODS: Cross-sectional data from 74,531 western European participants, aged 18-79 years, was used from the Dutch Lifelines Cohort Study...
April 18, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28420717/heart-lipids-and-hormones
#4
Peter Wolf, Yvonne Winhofer, Martin Krssak, Michael Krebs
Cardiovascular disease is the leading cause of death in general population. Besides well known risk factors like hypertension, impaired glucose tolerance and dyslipidemia, growing evidence suggests that also hormonal changes in various endocrine diseases impact cardiac morphology and function. Recent studies highlight the importance of ectopic intracellular myocardial and pericardial lipid deposition, since even slight changes of these fat depots are associated with alterations in cardiac performance. In this review we overview the effects of hormones, including insulin, thyroid hormones, growth hormone and cortisol, on heart function, focusing on their impact on myocardial lipid metabolism, cardiac substrate utilization and ectopic lipid deposition, in order to highlight the important role of even subtle hormonal changes for heart function in various endocrine and metabolic diseases...
April 18, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28420716/a-men1-pancreatic-neuroendocrine-tumour-mouse-model-under-temporal-control
#5
Kate E Lines, Roeland P Vas Nunes, Morten Frost, Christopher J Yates, Mark Stevenson, Rajesh Thakker
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by occurrence of parathyroid tumours, and neuroendocrine tumours (NETs) of the pancreatic islets and anterior pituitary. The MEN1 gene, encoding menin, is a tumour suppressor, but its precise role in initiating in vivo tumourigenesis remains to be elucidated. The availability of a temporally controlled conditional MEN1 mouse model would greatly facilitate the study of such early tumourigenic events, and overcome the limitations of other MEN1 knockout models, in which menin is lost from conception, or tumour development occurs asynchronously...
April 18, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28404685/rising-maternal-circulating-gh-during-murine-pregnancy-suggests-placental-regulation
#6
Kathryn L Gatford, Beverly Muhlhausler, Lili Huang, Pamela S-L Sim, Claire T Roberts, Johannes D Veldhuis, Chen Chen
Placenta-derived hormones including growth hormone (GH) in humans contribute to maternal adaptation to pregnancy, and intermittent maternal GH administration increases fetal growth in several species. Both patterns and abundance of circulating GH are important for its activity, but their changes during pregnancy have only been reported in humans and rats. The aim of the present study was to characterise circulating profiles and secretory characteristics of GH in non-pregnant female mice and throughout murine pregnancy...
April 12, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28381564/the-relationship-between-weight-gain-during-pregnancy-and-allopregnanolone-levels-a-longitudinal-study
#7
Anette Lundqvist, Herbert Sandström, Torbjörn Bäckström
OBJECTIVE: Excessive weight gain during pregnancy poses a risk for negative complications for mother and fetus. Hunger and satiety are regulated in the hypothalamus, where the gamma-amino-butyric acid system (GABA) plays an important role. Allopregnanolone, a progesterone metabolite, increases during pregnancy and is a potent GABA-A receptor modulating steroid. Allopregnanolone has been shown to induce overeating in rodents. The aim of this study was to investigate whether there is a relationship between weight gain and allopregnanolone concentrations during pregnancy in humans...
April 5, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28381563/the-gut-thyroid-axis-and-celiac-disease
#8
Aaron Lerner, Patricia Jeremias, Torsten Matthias
Autoimmune thyroiditis has an increased prevalence in patients with celiac disease and vice versa. The objective of the current review is to highlight the epidemiological, clinical, serological, pathological, pathophysiological, hormonal, genetic and immunological factors shared between the two entities. They might represent the two ends of the gut-thyroid axis where the cross-talks' pathways are still unrivalled. New observations are reviewed, highlighting some gut- thyroid interrelated pathways that potentially might lead to new therapeutic strategies...
April 5, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28381562/a-pilot-interventional-study-to-evaluate-the-impact-of-cholecalciferol-treatment-on-hba1c-in-type-1-diabetes
#9
Reena Perchard, Lucia Magee, Fiona Ivison, Andrew J Whatmore, Philip Murray, Adam Stevens, Sarah Ehtisham, Judith Campbell, Marie Marshall, Susan Ainsworth, Mark Bone, Ian Doughty, M Zulf Mughal, Peter E Clayton
BACKGROUND: Higher 25(OH)D3 levels are associated with lower Hba1c, but there are limited interventional trials assessing the effect of cholecalciferol on Hba1c. AIMS: (1) To assess baseline 25(OH)D3 status in a Manchester paediatric cohort of patients with T1D. (2) To determine the effect of cholecalciferol administration on Hba1c. METHODS: Children with T1D attending routine clinic appointments over three months in late winter/early spring had blood samples taken with consent, and patients with a 25(OH)D3 level <20ng/ml were treated with a one-off cholecalciferol dose of 100 000 (2-10 years) or 160 000 (>10 years) units...
April 5, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28373267/longitudinal-analyses-of-the-steroid-metabolome-in-obese-pcos-girls-with-weight-loss
#10
Thomas Reinehr, Alexandra Kulle, Juliane Rothermel, Caroline Knop, Nina Lass, Christina Bosse, Paul-Martin Holterhus
OBJECTIVE: The underlying mechanisms of polycystic ovarian syndrome (PCOS) are not fully understood yet. The aim of the study was to get functional insights into the regulation of steroid hormones in PCOS by steroid metabolomics. DESIGN: This is a longitudinal study of changes of steroid hormones in 40 obese girls aged 13-16 years (50% with PCOS) participating in a 1-year lifestyle intervention. Girls with and without PCOS were matched to age, BMI, and change of weight status...
April 3, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28348002/thyroid-function-in-children-and-adolescents-with-hashimoto-s-thyroiditis-after-l-thyroxine-discontinuation
#11
Giorgio Radetti, Mariacarolina Salerno, Chiara Guzzetti, Marco Cappa, Andrea Corrias, Alessandra Cassio, Graziano Cesaretti, Roberto Gastaldi, Mario Rotondi, Fiorenzo Lupi, Antonio Fanolla, Giovanna Weber, Sandro Loche
OBJECTIVE: Thyroid function may recover in patients with Hashimoto's thyroiditis (HT). DESIGN: To investigate thyroid function and the need to resume l-thyroxine treatment after discontinuation. SETTING: Nine Italian Pediatric Endocrinology centers. PATIENTS: 148 children and adolescents (25 m and 123 f) with HT on treatment with l-thyroxine for at least one year. Intervention and Main Outcome measure: Treatment was discontinued in all patients, and serum TSH and fT4 concentrations were measured at the time of treatment discontinuation and then after 2, 6, 12 and 24 months...
March 27, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28348001/dissecting-carboxypeptidase-e-properties-functions-and-pathophysiological-roles-in-disease
#12
Lin Ji, Huan-Tong Wu, Xiao-Yan Qin, Rongfeng Lan
Since discovered in 1982, carboxypeptidase E (CPE) is involved in the biosynthesis of a wide range of neuropeptides and peptide hormones in endocrine tissues and nervous system. This protein is produced from pro-CPE and exists in soluble and membrane forms. Membrane CPE mediates the targeting of prohormones to the regulated secretory pathway; while soluble CPE acts as an exopeptidase and cleaves C-terminal basic residues from peptide intermediates to generate bioactive peptides. CPE also participates in protein internalization, vesicle transport and regulation of signaling pathways...
March 27, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28336768/care-of-girls-and-women-with-turner-syndrome-beyond-growth-and-hormones
#13
Caroline Culen, Diana-Allexandra Ertl, Katharina Schubert, Lisa Bartha-Doering, Gabriele Haeusler
Turner syndrome (TS), although considered a rare disease, is the most common sex chromosome abnormality in women, with an incident of 1 in 2,500 female births. TS is characterized by distinctive physical features such as short stature, ovarian dysgenesis, an increased risk for heart and renal defects as well as a specific cognitive and psychosocial phenotype. Given the complexity of the condition, patients face manifold difficulties which increase over the lifespan. Furthermore, failures during the transitional phase to adult care result in moderate health outcomes and decreased quality of life...
March 23, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28325735/rescue-preoperative-treatment-with-lugol-s-solution-in-uncontrolled-graves-disease
#14
Jan Calissendorff, Henrik Falhammar
BACKGROUND: Graves' disease is a common cause of hyperthyroidism. Three therapies have been used for decades: pharmacologic therapy, surgery and radioiodine. In case of adverse events, especially agranulocytosis or hepatotoxicity, pre-treatment with Lugol's solution containing iodine/potassium-iodide to induce euthyroidism before surgery could be advocated but has rarely been reported. METHOD: All patients hospitalised due to uncontrolled hyperthyroidism at the Karolinska University Hospital 2005-2015 and treated with Lugol's solution were included...
March 21, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28298337/radiological-surveillance-in-multiple-endocrine-neoplasia-type-1-a-double-edged-sword
#15
Ruth Therese Casey, Deborah Saunders, Ben George Challis, Deborah Pitfield, Heok Cheow, Ashley Shaw, Helen Lisa Simpson
CONTEXT: Multiple endocrine neoplasia type 1 (MEN1) is a hereditary condition characterised by the predisposition to hyperplasia/tumours of endocrine glands. MEN1 related disease, moreover malignancy related to MEN1, is increasingly responsible for death in up to two-thirds of patients. Whilst patients undergo radiological and biochemical surveillance, current recommendations for radiological monitoring are based on non-prospective data with little consensus or evidence demonstrating improved outcome from this approach...
March 15, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28258126/effects-of-meal-and-incretins-in-the-regulation-of-splanchnic-blood-flow
#16
Jukka Koffert, Henri Honka, Jarmo Teuho, Saila Kauhanen, Saija Hurme, Riitta Parkkola, Vesa Oikonen, Andrea Mari, Andreas Lindqvist, Nils Wierup, Leif Groop, Pirjo Nuutila
OBJECTIVE: Meal ingestion is followed by a redistribution of blood flow (BF) within the splanchnic region contributing to nutrient absorption, insulin secretion and glucose disposal, but factors regulating this phenomenon in humans are poorly known. The aim of the present study was to evaluate the organ-specific changes in BF during a mixed-meal and incretin infusions. DESIGN: Non-randomized intervention study of 10 healthy adults to study splanchnic BF regulation...
March 3, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28249936/subclinical-hypothyroidism-to-treat-or-not-to-treat-a-systematic-review-with-meta-analysis-on-lipid-profile
#17
Isabel Abreu, Eva Lau, Bernardo Sousa-Pinto, Davide Carvalho
Previous studies suggested that subclinical hypothyroidism has a detrimental effect on cardiovascular risk factors, and that its effective treatment may have a beneficial impact on overall health. The main purpose of this review and meta-analysis was to assess whether subclinical hypothyroidism treatment is of clinical relevance, based on cardiovascular risk parameters correction. A systemic research of the literature using MEDLINE tool was performed to identify the relevant studies. Only placebo-controlled randomized control trials were included...
March 1, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28232367/association-of-vdr-polymorphisms-and-type-1-diabetes-susceptibility-in-children-a-meta-analysis
#18
Ozlem Sahin, Damla Gökşen, Aysel Ozpinar, Muhittin Serdar, Hüseyin Onay
OBJECTIVE: There are studies evluating FokI, BsmI, ApaI and TaqI polymorphisms of the vitamin D receptor gene and susceptibility to DM1 (type 1 diabetes mellitus) with controversial results. This present study aims to investigate the association between FokI, ApaI, TaqI and BsmI polymorphisms of vitamin D receptor (VDR) gene and DM1 in children. METHODS: A literature search was performed using Medline, EMBASE, Cochrane and Pubmed. Studies were included in the study if at least one of FokI, ApaI, TaqI and BsmI polymorphisms was determined and outcome was DM1 at pediatric age...
February 23, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28223310/overexpression-of-vitamin-d-receptor-mrna-correlates-with-poor-prognosis-in-ptc
#19
June Young Choi, Jin Wook Yi, Joon-Hyop Lee, Ra-Yeong Song, Hyeong Won Yu, Hyungju Kwon, Young Jun Chai, Su-Jin Kim, Kyu Eun Lee
The purpose of this study was to assess the relationship between vitamin D receptor (VDR) mRNA expression and prognosis in papillary thyroid cancer. RNA sequencing and somatic mutation data from TCGA (the Cancer Genome Atlas) were analyzed. VDR mRNA expression was compared to clinicopathologic variables by linear regression. Tree-based classification was applied to find VDR cutoff and patients were split into low and high VDR group. Logistic regression, Kaplan-Meier analysis, differentially expressed gene (DEG) test, and pathway analysis were performed to assess differences between groups...
February 21, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28219937/a-meta-analysis-of-prognostic-roles-of-molecular-markers-in-papillary-thyroid-carcinoma
#20
Huy Gia Vuong, Uyen N P Duong, Ahmed M A Altibi, Hanh T T Ngo, Thong Quang Pham, Hung Minh Tran, Greta Gandolfi, Lewis Hassell
The prognostic role of molecular markers in papillary thyroid carcinoma (PTC) is a matter of ongoing debate. The aim of our study is to investigate the impact of RAS, BRAF, TERT promoter mutations and RET/PTC rearrangements on prognosis of PTC patients. We performed a search in four electronic databases: PubMed, Scopus, Web of Science and Virtual Health Library (VHL). Data of hazard ratio (HR) and its 95% confidence interval (CI) for Disease-specific survival (DSS) and Disease-free survival (DFS) were directly obtained from original papers or indirectly estimated from Kaplan Meier curve (KMC)...
February 20, 2017: Endocrine Connections
journal
journal
47734
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"