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Endocrine Connections

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https://www.readbyqxmd.com/read/29335252/diagnostic-reevaluation-of-congenital-hypothyroidism-in-macedonia-predictors-for-transient-or-permanent-hypothyroidism
#1
Nikolina Zdraveska, Maja Zdravkovska, Violeta Anastasovska, Elena Sukarova-Angelovska, Mirjana Kocova
BACKGROUND: Diagnostic re-evaluation is important for all patients with congenital hypothyroidism (CH) for determining the etiology and identifying transient CH cases. Our study is a first thyroxine therapy withdrawal study conducted in Macedonian CH patients for a diagnostic re-evaluation. We aimed to evaluate the etiology of CH, the prevalence of transient CH and identify predictive factors for distinguishing between permanent (PCH) and transient CH (TCH). MATERIAL AND METHODS: Patients with CH aged > 3 years underwent a trial of treatment withdrawal for 4 weeks period...
January 15, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29335251/goblet-cell-carcinomas-of-the-appendix-rare-but-aggressive-neoplasms-with-challenging-management
#2
Ashley Kieran Clift, Oskar Kornasiewicz, Panagiotis Drymousis, Omar Faiz, Harpreet Wasan, James Kinross, Thomas Cecil, Andrea Frilling
Goblet cell carcinomas (GCC) are a rare, aggressive sub-type of appendiceal tumours with neuroendocrine features, and controversy exists with regards to therapeutic strategy. We undertook a retrospective review of GCC patients surgically treated at two tertiary referral centres. Clinical and histopathological data were extracted from a prospectively maintained database. Survival analyses utilised Kaplan-Meier methodology. Twenty-one patients were identified (9 females). Median age at diagnosis was 55years (range 32-77)...
January 15, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29330338/diagnosis-management-histology-and-genetics-of-sporadic-primary-hyperparathyroidism-old-knowledge-with-new-tricks
#3
Maria Mizamtsidi, Constantinos Nastos, George Mastorakos, Roberto Dina, Ioannis Vassiliou, Maria Gazouli, Fausto Palazzo
Primary hyperparathyroidism (pHPT) is a common endocrinopathy resulting from inappropriately high PTH secretion. It usually results from the presence of a single gland adenoma, multiple gland hyperplasia or rarely parathyroid carcinoma. All these conditions require different management and it is important to be able to differentiate the underlined pathology, in order for the clinicians to provide the best therapeutic approach. Elucidation of the genetic background of each of these clinical entities would be of great interest...
January 12, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29321175/upregulation-of-gh-but-not-igf1-in-the-hippocampus-of-the-lactating-dam-after-kainic-acid-injury
#4
Elvira C Arellanes-Licea, Jose Avila-Mendoza, Elizabeth C Ramirez-Martinez, Eugenia Ramos, Nancy Uribe-Gonzalez, Carlos Aramburo, Teresa Morales, Maricela Luna
Lactation embodies a natural model of morphological, neurochemical, and functional brain plasticity. In this reproductive stage, the hippocampus of the female is less sensitive to excitotoxins in contrast to nulliparity. Growth hormone (GH) and insulin-like growth factor 1 (IGF1) are known to be neuroprotective in several experimental models of brain lesion. Here, activation of the GH-IGF1 pituitary-brain axis following kainic acid (7.5 mg/kg ip KA) lesion was studied in lactating and nulliparous rats. Serum concentrations of GH and IGF1 were uncoupled in lactation...
January 10, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29317405/coagulation-and-fibrinolysis-in-hyperparathyroidism-secondary-to-vitamin-d-deficiency
#5
Laura P B Elbers, Marije Wijnberge, Joost C M Meijers, Dennis C W Poland, Dees P M Brandjes, Eric Fliers, Victor E A Gerdes
INTRODUCTION: Abnormal coagulation tests have been observed in patients with primary hyperparathyroidism (HPT) suggesting a prothrombotic effect of parathyroid hormone (PTH). Vitamin D deficiency (VIDD) is the most frequent cause of secondary HPT. Aim of our study was to investigate the influence of HPT secondary to moderate-severe VIDD and vitamin D replacement on the coagulation and fibrinolysis system. SUBJECTS AND METHODS: Prospective cohort study of patients with vitamin D<25 nmol/l with and without HPT, and a control group of patients on vitamin D suppletion...
January 9, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29305399/edc-impact-is-exposure-during-pregnancy-to-acetaminophen-paracetamol-disrupting-female-reproductive-development
#6
Frederic Schrøder Arendrup, Séverine Mazaud-Guittot, Bernard Jégou, David Møbjerg Kristensen
Concern has been raised over chemical induced disruption of ovarigenesis during fetal life resulting in long-lasting consequences only manifesting themselves much later during adulthood. A growing body of evidence suggest that prenatal exposure to the mild analgesic acetaminophen/paracetamol can cause such a scenario. In this Review, we therefore discuss three recent reports that collectively indicating that prenatal exposure in a window around 13.5 days post coitum in both rats and mouse can result in reduced female reproductive health...
January 5, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29301864/effect-of-autotransplantation-of-a-parathyroid-gland-on-hypoparathyroidism-after-total-thyroidectomy
#7
Anping Su, Yanping Gong, Wenshuang Wu, Rixiang Gong, Zhihui Li, Jingqiang Zhu
BACKGROUND: The effect of parathyroid autotransplantation on hypoparathyroidism is not fully understood. The purpose of the study was to determine the effect of autotransplantation of a parathyroid gland on the incidence of hypoparathyroidism and recovery of parathyroid function at 6 months after total thyroidectomy with central neck dissection for papillary thyroid carcinoma. METHODS: All patients with autotransplantation of a parathyroid gland (no inadvertent parathyroidectomy) (group A), in situ preservation of all parathyroid glands (no autotransplantation and inadvertent parathyroidectomy) (group B), or inadvertent removal of a parathyroid gland (no autotransplantation) (group C) who underwent first-time total thyroidectomy with central neck dissection for papillary thyroid carcinoma between January 2013 and June 2016 were included retrospectively...
January 4, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29301863/faecal-corticosterone-metabolites-assessment-in-socially-housed-male-and-female-wistar-rats
#8
Carlo Cinque, Manuela Zinni, Anna Rita Zuena, Chiara Giuli, Sebastiano Giovanni Alemà, Assia Catalani, Paola Casolini, Roberto Cozzolino
Knowledge of animals' hormonal status is important for conservation studies in wild or semi-free ranging conditions as well as for behavioural and clinical experiments conducted in laboratory research, mostly performed on rats and mice. Faecal sampling is a useful non-invasive method to obtain steroid hormone assessments. Nevertheless, in laboratory studies, unlike other contexts, faecal sampling is less utilised. One of the issues raised is the necessity to collect samples belonging to different animals, separately...
January 4, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29242356/pre-treatment-growth-and-igf-i-deficiency-as-main-predictors-of-response-to-growth-hormone-therapy-in-neural-models
#9
Urszula Smyczynska, Joanna Smyczynska, Maciej Hilczer, Renata Stawerska, Ryszard Tadeusiewicz, Andrzej Lewinski
Mathematical models have been applied in prediction of growth hormone treatment effectiveness in children since the end of 1990s. Usually they were multiple linear regression models, however there are also examples derived by empirical non-linear methods. Proposed solution consists in application of machine learning technique - artificial neural networks - to analyse this problem. This new methodology, contrary to previous ones, allows detection of both linear and non-linear dependencies without assuming their character a priori...
December 14, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29237763/bisphenol-a-phthalate-metabolites-and-glucose-homeostasis-in-healthy-normal-weight-children
#10
Amalie Carlsson, Kaspar Sørensen, Anna-Maria Andersson, Hanne Frederiksen, Anders Juul
INTRODUCTION: Bisphenol A and several of the most commonly used phthalates have been associated with adverse metabolic health effects such as obesity and diabetes. Therefore, we analyzed these man-made chemicals in first morning urine samples from 107 healthy normal-weight Danish children and adolescents. METHOD: This was a cross-sectional study. Participants were recruited as part of The COPENHAGEN Puberty Study. The subjects were evaluated by an oral glucose tolerance test (OGTT), a dualenergy X-ray absorptiometry (DXA) scan, direct oxygen uptake measurement during cycle ergometry, and fasting blood samples...
December 13, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29233817/exogenous-insulin-antibody-syndrome-eias-a-clinical-syndrome-associated-with-insulin-antibodies-induced-by-exogenous-insulin-in-diabetic-patients
#11
Xiaolei Hu, Fengling Chen
Insulin has been used for diabetes therapy and has achieved significant therapeutic effect. In recent years, the use of purified and recombinant human insulin preparations has markedly reduced, but not completely suppressed, the incidence of insulin antibodies (IAs). IAs induced by exogenous insulin in diabetic patients is associated with clinical events, which is named exogenous insulin antibody syndrome (EIAS). The present review is based on our research and summarizes the characterization of IAs, the factors affecting IA development, the clinical significance of IAs and the treatments for EIAS...
December 12, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29233816/testosterone-level-and-risk-of-type-2-diabetes-in-men-a-systematic-review-and-meta-analysis
#12
Qiuming Yao, Bin Wang, Xiaofei An, Jin-An Zhang, Liumei Ding
BACKGROUND: Type 2 diabetes is a risk factor for testosterone deficiency and impaired sex steroid status. Some studies also investigated the association of testosterone level with diabetes risk in men, but reported controversial findings. To clarify this issue, we conducted a systematic review and meta-analysis. METHODS: Pubmed, Embase, and Web of Science were searched for eligible cohort or nested case-control studies published up to August 15, 2017. Meta-analysis was used to calculate the pooled relative risk (RR) of type 2 diabetes associated with higher testosterone level...
December 12, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29233815/dual-release-hydrocortisone-treatment-glycometabolic-profile-and-health-related-quality-of-life
#13
Laura Maria Mongioì, Rosita Angela Condorelli, Sandro La Vignera, Aldo E Calogero
OBJECTIVE: Adrenal insufficiency (AI) is a chronic condition associated with increased mortality and morbidity. The treatment of AI in the last years it has been object of important changes due to the development of a dual-release preparation of hydrocortisone, that differs from previous therapeutic strategy as it contemplates a once-daily tablet that allows more closely mimicking the physiological circadian rhythm cortisol. The aim of the study was to evaluate the effects of dual-release hydrocortisone treatment on the glycometabolic profile and health-related quality of life of patients with AI...
December 12, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29217653/exenatide-treatment-causes-suppression-of-serum-fasting-ghrelin-levels-in-patients-with-type-2-diabetes-mellitus
#14
Metin Guclu, Sinem Kiyici, Zulfiye Gul, Sinan Cavun
AIM: In the present study we investigated the long-term effects of exenatide treatment on serum fasting ghrelin levels in patients with type 2 diabetes mellitus. METHODS: Type 2 diabetic patients, who were using metformin with and without the other antihiperglycemic drugs on a stable dose for at least 3 months, were enrolled in the study. BMI>35 kg/m2 and HbA1c>7.0% were the additional inclusion criteria. Oral antihyperglycemic drugs, other than metformin, were stopped and metformin treatment was continued at 2000 mg per day...
December 7, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29217652/initial-clinical-presentation-and-spectrum-of-pheochromocytoma-a-study-of-94-cases-from-a-single-center
#15
Henrik Falhammar, Magnus Kjellman, Jan Calissendorff
BACKGROUND: With the increasing access to imaging more pheochromocytomas are diagnosed in the workup of adrenal incidentalomas. This may have changed the occurrence of the classic presentation with hypertension and the classic triad (headaches, sweating and palpitation). METHODS: We reviewed 94 consecutive cases of pheochromocytomas. Two cases of ectopic ACTH-syndrome were subsequently excluded. RESULTS: Of the 92 cases included 64% had presented as an incidentaloma, 32% as a suspected pheochromocytoma and 4% had been screened because of previously diagnosed MEN2A...
December 7, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29217651/interleukin-18-serum-level-is-elevated-in-type-2-diabetes-and-latent-autoimmune-diabetes
#16
Emanuela Zaharieva, Zdravko Kamenov, Tsvetelina Velikova, Adelina Tsakova, Yosif El-Darawish, Haruki Okamura
BACKGROUND: Interleukin-18 (IL-18) is an inflammatory cytokine found to be elevated in obesity, metabolic syndrome and type 2 diabetes (T2D) as a part of the chronic low-grade inflammatory process in these states. The aim of the study was to evaluate the interleukin level in patients with latent autoimmune diabetes of the adults (LADA) in comparison to that in T2D subjects. MATERIALS AND METHODS: IL-18 was analyzed through Enzyme-Linked Immunosorbent Assay in 76 participants with T2D and 24 with LADA and 14 control subjects...
December 7, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29217650/serum-and-urine-vitamin-d-metabolite-analysis-in-early-preeclampsia
#17
Jennifer Tamblyn, Carl Jenkinson, Dean Larner, Martin Hewison, Mark Kilby
Vitamin D-deficiency is common in pregnant women, and may contribute to adverse events in pregnancy such as preeclampsia (PET). To date, studies of vitamin D and PET have focused primarily on serum concentrations vitamin D, 25-hydroxyvitamin D3 (25(OH)D3) later in pregnancy. The aim here was to determine whether a more comprehensive analysis of vitamin D metabolites earlier in pregnancy could provide predictors of PET. Using samples from the SCOPE pregnancy cohort, multiple vitamin D metabolites were quantified by liquid chromatography-tandem mass spectrometry in paired serum and urine prior to the onset of PET symptoms...
December 7, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29203468/edc-impact-reduced-sperm-counts-in-rats-exposed-to-human-relevant-mixtures-of-endocrine-disrupters
#18
Marta Axelstad, Ulla Hass, Martin Scholze, Sofie Christiansen, Andreas Kortenkamp, Julie Boberg
Human semen quality is declining in many parts of the world, but the causes are ill-defined. In rodents, impaired sperm production can be seen with early life exposure to certain endocrine disrupting chemicals, but the effects of combined exposures are not properly investigated. In this study, we examined the effects of early exposure to the painkiller paracetamol and mixtures of human relevant endocrine disrupting chemicals in rats. One mixture contained four estrogenic compounds, another contained eight anti-androgenic environmental chemicals, and a third mixture contained estrogens, anti-androgens and paracetamol...
December 4, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29196301/interobserver-agreement-of-various-thyroid-imaging-reporting-and-data-systems
#19
Giorgio Grani, Livia Lamartina, Vito Cantisani, Marianna Maranghi, Piernatale Lucia, Cosimo Durante
Ultrasonography is the best available tool for the initial work-up of thyroid nodules. Substantial interobserver variability has been documented in the recognition and reporting of some of the lesion characteristics. A number of classification systems have been developed to estimate the likelihood of malignancy: several of them have been endorsed by scientific societies, but their reproducibility has yet to be assessed. We evaluated the interobserver variability of the AACE/ACE/AME, ACR, ATA, EU-TIRADS, and K-TIRADS classification systems and the interobserver concordance in the indication to FNA biopsy...
December 1, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29191920/combined-test-of-serum-cga-and-nse-improved-the-power-of-prognosis-prediciton-of-nf-pnets
#20
Yang Lv, Xu Han, Chunyan Zhang, Yuan Fang, Ning Pu, Yuan Ji, Dansong Wang, Xuefeng Xu, Wenhui Lou
PURPOSE: Chromogranin-A (CgA) and neuron-specific enolase (NSE) are important markers for neuroendocrine tumors, however, the clinical value of combining these markers has not been well studied. In this study we investigated the utility of each marker individually and in combination for patients with nonfunctional pancreatic neuroendocrine tumors (NF-pNETs). PATIENTS AND METHODS: In this study, NF-pNETs patients and controls were recruited from December 2011 to March 2016; 784 serum samples from peripheral vein were collected...
November 30, 2017: Endocrine Connections
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