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Pediatric Gastroenterology, Hepatology & Nutrition

Ji Eun Jeong, Kyung Moon Kim, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Jung Yeon Shim, Moon Soo Park, Soo Kyung Park
Epstein-Barr virus (EBV) infection can be presented with various clinical manifestations and different levels of severity when infected. Infectious mononucleosis, which is most commonly caused by EBV infection in children and adolescents, is a clinical syndrome characterized by fatigue, malaise, fever, sore throat, and generalized lymphadenopathy. But rarely, patients with infectious mononucleosis may present with gastrointestinal symptoms and complicated by gastritis, splenic infarction, and splenic rupture...
April 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Youngmin Youn, Sang Won Lee, Hyun-Hae Cho, Sanghui Park, Hae-Sun Chung, Jeong Wan Seo
Nowadays, Klebsiella oxytoca is described as a causative organism for antibiotic-associated hemorrhagic colitis (AAHC). Here we report two cases of pediatric AAHC, from which K. oxytoca was cultured after starting amoxicillin-clavulanate or amoxicillin treatment. The patients developed severe abdominal pain and a large amount of bloody diarrhea. K. oxytoca was obtained in intestinal fluid culture of a boy through the colonoscopy. On the other hand, colonic tissue culture and intestinal fluid culture were negative of the other patient...
April 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Helena Ferreira, Raquel Nuñez Ramos, Cinthia Flores Quan, Susana Redecillas Ferreiro, Vanessa Cabello Ruiz, Javi Juampérez Goñi, Jesus Quintero Bernabeu, Oscar Segarra Cantón, Marina Álvarez Beltran
Chylomicron retention disease, also known as Anderson's disease, is a rare hereditary hypocholesterolemic disorder, recessive inherited, characterized by nonspecific symptoms as abdominal distension, steatorrhea, and vomiting associated with failure to thrive. We describe a patient with failure to thrive, chronic diarrhea and steatorrhea who the diagnosis of chylomicron retention disease was established after several months of disease progression. The genetic study confirmed a homozygosity mutation in SAR1B gene, identifying a mutation never previous described [c...
April 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Eun Hye Park, Min-Su Oh, Sorina Kim, Juyeon Lee, Ki Soo Kang
Purpose: For 3 consecutive years from 2012-2014, we analyzed the causative factors for why the Jeju Island had the highest obesity prevalences of school children among the 15 provinces in Korea. Methods: From our analysis of 28,026 elementary school children with obesity or normal weight in the 15 provinces, we analyzed 12 factors related to eating habits, exercise habits, lifestyle, and mental health. The differences between the obese and normal weight children were researched...
April 2018: Pediatric Gastroenterology, Hepatology & Nutrition
José Vicente Arcos-Machancoses, Cristina Molera Busoms, Ecaterina Julio Tatis, María Victoria Bovo, Jesús Quintero Bernabeu, Javier Juampérez Goñi, Vanessa Crujeiras Martínez, Javier Martin de Carpi
Purpose: Classical criteria for diagnosis of autoimmune hepatitis (AIH) are intended as research tool and are difficult to apply at patient's bedside. We aimed to study the accuracy of simplified criteria and the concordance with the expert diagnosis based on the original criteria. Methods: A cohort of children under study for liver disorder was selected through consecutive sampling to obtain the prevalence of AIH within the group of differential diagnoses. AIH was defined, based on classical criteria, through committee review of medical reports...
April 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Fatih Battal, Hakan Türkön, Nilüfer Aylanç, Hakan Aylanç, Şule Yıldırım, Nazan Kaymaz, Sema Uysal
Purpose: The prevalence of obesity has significantly increased among children and adolescents worldwide and is becoming an important health care problem in parallel with the increased prevalence of obesity pediatric non-alcoholic fatty liver disease. Betatrophin is a newly define hormone that is commonly secreted by liver and plays role in glucose tolerance. This study aimed to investigate the relationship between serum betatrophin levels and non-alcoholic fatty liver disease in obese children...
April 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Atchariya Chanpong, Seksit Osatakul
Purpose: Functional constipation (FC) is a common gastrointestinal (GI) problem affecting children's well-being and quality of life. Although polyethylene glycol (PEG) is recommended as the first line therapy, it is not always applicable in lower socioeconomic populations. Hence, this study aimed to compare clinical courses of FC in children treated with different medications in order to identify prognostic factors related to treatment outcomes. Methods: We reviewed the medical records of patients aged ≤15 years diagnosed with FC according to the Rome IV criteria from 2007 to 2015 at the GI clinic, Songklanagarind Hospital...
April 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Reema Gulati, Arpitha Komuravelly, Stephen Leb, Maroun J Mhanna, Abdullah Ghori, Janeen Leon, Robert Needlman
Purpose: Rome criteria are considered the gold standard for diagnosing functional constipation. The modified Bristol stool form scale (m-BSFS) was validated to measure stool form in children. However, neither the potential use of the m-BSFS as a tool to facilitate the diagnosis of potential constipation, nor the agreement between m-BSFS and stool consistency by Rome has been studied. Our objective is to determine if m-BSFS is a reliable tool to facilitat detection of constipation; and the agreement between stool form by m-BSFS and hard stool criteria in Rome...
April 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Pooja Semwal, Raj Kumar Gupta, Rahul Sharma, Kapil Garg
Purpose: Celiac disease is a common non-communicable disease with varied presentations. Purpose of this study was to find the duodeno-endoscopic features in celiac disease and to compare duodeno-endoscopic and histological findings between typical and atypical celiac disease in children. Methods: Hospital based observational study was conducted at Sir Padampat Mother and Child Health Institute, Jaipur from June 2015 to May 2016. Patients were selected and divided in two groups- typical and atypical celiac disease based upon the presenting symptoms...
April 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Yeoun Joo Lee
Increased awareness of the importance of nutrition among hospitalized children has increased the use of nutrition screening tool (NST). However, it is not well known the NST for hospitalized children. Therefore, the purpose of this study is to understand the past and present state of adult and child NST and discuss the pros and cons of each NST.
April 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Wei Cai, Lalit Bharadia, Mohammad Juffrie, Fook Choe Cheah, Seng Hock Quak, Vitaya Titapant, Ruurd van Elburg, Thomas Ludwig
No abstract text is available yet for this article.
January 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Charu Tiwari, Ashish Zadpe, Pravin Rathi, Hemanshi Shah
Colorectal carcinoma is a well-known malignancy in adults. However, it is rare in children. Besides, it also has different behaviour in paediatric age-group and usually presents with non-specific symptoms like abdominal pain, weight loss, and anaemia. This usually leads to delay in diagnosis. Adenocarcinoma in children has unfavourable tumour histology (mucinous subtype) and advanced disease stage at presentation which lead to poorer prognosis in children. Family history, genetic typing and sibling screening are essential components of management as this malignancy is frequently seen associated with hereditary syndromes...
January 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Racha Khalaf, Carmen Cuffari
Androgen therapy has proven efficacy in treating patients with bone marrow failure who are not candidates for bone marrow transplantation. Herein, we report on a case of colonic angioectasia secondary to oxymetholone use in an adolescent patient with Hoyeraal-Hreidarsson syndrome (HHS). A 13-year-old Caucasian male with HHS characterized by cerebellar hypoplasia, developmental delay, microcephaly, esophageal strictures and myelodysplasia presented with severe hematochezia from colonic angioectasia secondary to long-term oxymetholone therapy...
January 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Carlos Alberto Nogueira-de-Almeida, Elza Daniel de Mello
Purpose: to compare cut off points corrected for age and gender (COOP) with fixed cut off points (FCOP) for fasting plasma insulin and Homeostatic model assessment-insulin resistance (HOMA-IR) for the diagnosis of IR in obese children and adolescents and their correlation with dyslipidemia. Methods: A multicenter, cross-sectional study including 383 subjects aged 7 to 18 years, evaluating fasting blood glucose, plasma insulin, and lipid profile. Subjects with high insulin levels and/or HOMA-IR were considered as having IR, based on two defining criteria: FCOP or CCOP...
January 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Chun Woo Song, Joon Won Kang, Jae Young Kim
Purpose: To clarify the clinical features of appendicitis in preschool children and to explore clinical appendicitis scoring systems in this age group. Methods: We retrospectively collected data on 142 children, aged 10 years or younger, with confirmed diagnosis of appendicitis based on surgical and pathologic findings. Enrolled subjects were divided into two groups: Group 1 (preschool children aged ≤5 years, n=41) and Group 2 (school children aged >5 to ≤10 years, n=101)...
January 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Do Hyun Kim, Jin Min Cho, Hye Ran Yang
Purpose: Clostridium difficile colonization and infection are commonly associated with poor outcomes in patients with pediatric inflammatory bowel disease (PIBD). We aimed to investigate the prevalence of C. difficile colonization and infection at the time of diagnosis and to evaluate risk factors associated with the development of C. difficile infection during the course of PIBD treatment. Methods: We retrospectively enrolled a total of 59 children who were newly diagnosed with PIBD at the tertiary medical center...
January 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Kwang Yeon Kim, Eun Joo Lee, Ju Whi Kim, Jin Soo Moon, Ju Young Jang, Hye Ran Yang, Jae Sung Ko
Purpose: Monogenic inflammatory bowel disease (IBD) patients do not respond to conventional therapy and are associated with a higher morbidity. We summarized the clinical characteristics of monogenic IBD patients and compared their clinical outcomes to that of non-monogenic IBD patients. Methods: We performed a retrospective cohort study of all children <18 years old who were diagnosed with IBD between 2005 and 2016. A total of 230 children were enrolled. Monogenic IBD was defined as a presentation age less than 6 years old with confirmation of a genetic disorder...
January 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Ioannis Xinias, Antonis Analitis, Antigoni Mavroudi, Ioannis Roilides, Maria Lykogeorgou, Varvara Delivoria, Vasilis Milingos, Mayra Mylonopoulou, Yvan Vandenplas
Purpose: To evaluate the efficacy of synbiotic formula with partial whey hydrolysate and high magnesium content in infants presenting with functional constipation. Methods: Sixty-five infants with functional constipation were included. Forty infants were treated during one month with parental reassurance and the intervention formula and were compared to a control group of 25 infants treated with parental reassurance only. Parents completed a quality of life (QoL) questionnaire at baseline and during the last week of the study...
January 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Kyung In Lim, Sung Bo Shim, Hann Tchah, Eell Ryoo
Purpose: Minimal change esophagitis (MCE) is a reflux disease without mucosal breaks, known to be partially associated with abnormal gastric motor function. Electrogastrography (EGG) is commonly applied to assess gastric motor function in a noninvasive fashion. We aimed to determine the relationship between MCE and gastric myoelectrical activity (GME) recorded on EGG in children. Methods: We retrospectively assessed the records of 157 children without underlying disease who underwent both EGG and upper gastrointestinal endoscopy at Gachon University Gil Medical Center between January 2010 and June 2015...
January 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Dae Yong Yi
Pediatric patients require specialized attention and have diverse demands for proper growth and development, and thus need a different approach and interest in nutritional assessment and supply. Enteral nutrition is the most basic and important method of nutritional intervention, and its indications should be identified. Also, the sites, modes, types, and timing of nutritional intervention according to the patient's condition should be determined. In addition, various complications associated with enteral nutrition supply should be identified, and prevention and treatment are required...
January 2018: Pediatric Gastroenterology, Hepatology & Nutrition
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