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Translational Medicine @ UniSa

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https://www.readbyqxmd.com/read/30083522/pilot-study-on-epigenetic-response-to-a-mind-body-treatment
#1
M Cozzolino, F Guarino, S Castiglione, A Cicatelli, G Celia
In the last years, epigenetics and functional genomics methods to evaluate the genomic effects and mechanisms of mind-body therapies have increasingly grown. DNA microarray technology has been used to show the involvement of the stress response pathways both in the case of disease and stress and as an effect of mind-body therapies. In the present research, the DNA samples obtained from 20 individuals who experienced a mind-body therapeutic protocol (MBT-T), were analysed from the bio-molecular point of view by means of an epigenetic marker (MSAP molecular tool), in order to estimate the different status of methylation...
July 2017: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/30083521/mean-reticolocyte-hemoglobin-content-index-plays-a-key-role-to-identify-children-who-are-carriers-of-%C3%AE-thalassemia
#2
Paolo Vicinanza, Mariella Vicinanza, Vincenzo Cosimato, Daniela Terracciano, Sergio Cancellario, Angelo Massari, Paolo Danise, Carmine Selleri, Bianca Serio
Reticulocyte (r) and red blood cell (RBC) indices provide reliable parameters for screening and monitoring iron deficiency anemia (IDA) patients and β-thalassemia trait (BTT) carriers. The aim of this study is to identify a simple method for use to distinguish β-thalassemia trait carriers from IDA and to evaluate the correlation between BTT genetic mutation and MCV values and new discrimination index for the detection of β-thalassemia trait (DI-BTT). We analyzed CHr, MCHCr, MCVr, RBC, mean cellular hemoglobin concentration (MCHC) and mean cellular volume (MCV) indices among a pediatric population of IDA patients (n=90), β-thalassemia trait carriers (n=72) and normal controls (NC) (n=131)...
July 2017: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/30083520/sirna-delivery-for-control-of-cyclin-d1-and-e2f1-expression-in-crohn-s-disease
#3
Ilaria Russo, Albino Carrizzo, Sabrina Bochicchio, Ornella Piazza, Gaetano Lamberti, Anna Angela Barba, Carmine Vecchione, Pio Zeppa, Paola Iovino, Cristina Bucci, Antonella Santonicola, Carolina Ciacci
Evidence in inflammatory bowel diseases (IBD) supports a connection between inflammation and cancer due to the alteration of the cell cycle with loss of control at the G1/S checkpoint. In this study, we analyze the expression and modulation of CyD1 and E2F1 in colon explants from Crohn's disease (CD) patients. We used ex vivo culture of colon explants from 4 CD patients and 2 healthy controls, stimulated with lipopolysaccharide from Escherichia Coli (EC-LPS). Commercial siRNAs for CyD1 and E2F1 inhibition were encapsulated in Invivofectamine® and in purposely produced nanoliposomal vectors to silencing CyD1 and E2F1 expression...
July 2017: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/30050879/pilot-study-on-epigenetic-response-to-a-mind-body-treatment
#4
M Cozzolino, F Guarino, S Castiglione, A Cicatelli, G Celia
In the last years, epigenetics and functional genomics methods to evaluate the genomic effects and mechanisms of mind-body therapies have increasingly grown. DNA microarray technology has been used to show the involvement of the stress response pathways both in the case of disease and stress and as an effect of mind-body therapies. In the present research, the DNA samples obtained from 20 individuals who experienced a mind-body therapeutic protocol (MBT-T), were analysed from the bio-molecular point of view by means of an epigenetic marker (MSAP molecular tool), in order to estimate the different status of methylation...
July 2017: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/30050878/mean-reticolocyte-hemoglobin-content-index-plays-a-key-role-to-identify-children-who-are-carriers-of-%C3%AE-thalassemia
#5
Paolo Vicinanza, Mariella Vicinanza, Vincenzo Cosimato, Daniela Terracciano, Sergio Cancellario, Angelo Massari, Paolo Danise, Carmine Selleri, Bianca Serio
Reticulocyte (r) and red blood cell (RBC) indices provide reliable parameters for screening and monitoring iron deficiency anemia (IDA) patients and β-thalassemia trait (BTT) carriers. The aim of this study is to identify a simple method for use to distinguish β-thalassemia trait carriers from IDA and to evaluate the correlation between BTT genetic mutation and MCV values and new discrimination index for the detection of β-thalassemia trait (DI-BTT). We analyzed CHr, MCHCr, MCVr, RBC, mean cellular hemoglobin concentration (MCHC) and mean cellular volume (MCV) indices among a pediatric population of IDA patients (n=90), β-thalassemia trait carriers (n=72) and normal controls (NC) (n=131)...
July 2017: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/30050877/sirna-delivery-for-control-of-cyclin-d1-and-e2f1-expression-in-crohn-s-disease
#6
Ilaria Russo, Albino Carrizzo, Sabrina Bochicchio, Ornella Piazza, Gaetano Lamberti, Anna Angela Barba, Carmine Vecchione, Pio Zeppa, Paola Iovino, Cristina Bucci, Antonella Santonicola, Carolina Ciacci
Evidence in inflammatory bowel diseases (IBD) supports a connection between inflammation and cancer due to the alteration of the cell cycle with loss of control at the G1/S checkpoint. In this study, we analyze the expression and modulation of CyD1 and E2F1 in colon explants from Crohn's disease (CD) patients. We used ex vivo culture of colon explants from 4 CD patients and 2 healthy controls, stimulated with lipopolysaccharide from Escherichia Coli (EC-LPS). Commercial siRNAs for CyD1 and E2F1 inhibition were encapsulated in Invivofectamine® and in purposely produced nanoliposomal vectors to silencing CyD1 and E2F1 expression...
July 2017: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/30050876/transcatheter-implantable-devices-to-monitoring-of-elevated-left-atrial-pressures-in-patients-with-chronic-heart-failure
#7
R De Rosa, F Piscione, D Schranz, R Citro, S Iesu, G Galasso
Elevated left atrial (LA) pressures are associated with poor prognosis in heart failure (HF). Invasive monitoring of LA-pressures and direct mechanical LA-decompression are associated with functional improvement in patients suffering from HF both with reduced and preserved ejection fraction. We aim to review the current available percutaneously implantable sensors for haemodynamic telemonitoring of LA-pressures (direct LAP sensor device-HeartPOD; right ventricular device-Chronicle; pulmonary artery device-CardioMEMs)...
July 2017: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/30050875/micrornas-and-cardiovascular-diseases-from-bench-to-bedside
#8
R De Rosa, M V Polito, R Benvenga, E De Angelis, F Piscione, G Galasso
MicroRNAs (microRNAs or miRs) are small, non-coding RNAs that control gene expression by binding to and repressing specific mRNA target and have emered as powerful regulators of many biological processes. Understanding miRNAs-biology and functions may be pivotal to get a better insight into pathophysiological mechanisms responsible for a large number of morbid conditions and may lay the foundations for the development of novel therapeutic interventions. Moreover, besides their intracellular functions, miRs are present in the human circulation in a remarkably stable cell-free form, and their plasmatic levels have been proposed as biomarkers for several pathological conditions...
July 2017: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/30050874/elective-orthopaedic-and-trauma-patients-in-southern-italy-are-vitamin-d-deficient-a-pilot-study
#9
Antonio Foccillo, Rocco Aicale, Nicola Maffulli
Many patients present with Vitamin D (Vit d; 25 (OH) D) deficiency on admission to hospital. The present study evaluated the levels of serum concentration of 25 (OH) D in patients undergoing elective arthroplasty of the hip and knee and in patients with proximal femur fracture. A total of 90 patients of both sex were recruited, 20 with osteoarthritis of the knee, 29 with osteoarthritis of the hip, and 41 with a hip fracture. The levels of Vit D were measured twice: on admission and on the fourth day after surgery...
July 2017: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/30050873/leg-fracture-associated-with-synostosis-of-interosseous-membrane-during-running-in-a-soccer-player
#10
F Oliva, R Buharaja, R Iundusi, U Tarantino
Introduction: Leg fractures may occur frequently in sport injuries but it is very rare to find this kind of injury associated with interosseous membrane synostosis. This case report describes a unique case of 42 B1.2 fracture of the leg associated with an interosseous membrane synostosis and literature review on Pubmed, Google scholar and Medscape. Case Presentation: A 26 year old male amateur soccer player came to our attention at the emergency room after a fall while he was running without any direct trauma following a referred ankle sprain...
July 2017: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/28775964/obesity-and-obesity-related-diseases-sugar-consumption-and-bad-oral-health-a-fatal-epidemic-mixtures-the-pediatric-and-odontologist-point-of-view
#11
Anna Pia Delli Bovi, Laura Di Michele, Giuliana Laino, Pietro Vajro
Obesity and dental caries are increasingly widespread pathologies. The former is growing so rapidly that the WHO classified its trend as an "epidemic". Both are triggered by a number of well known common etiologic factors sharing also the high added sugar amount since childhood. Because of its fermentation and pH lowering, dietary sugar allows the cariogenic bacteria to damage the tooth enamel provoking the carious lesions. WHO guidelines recommend reducing sugar intake to 10% of the total daily energy need, and highlight that there is evidence which suggests cuttingthis value down to 5% at least...
January 2017: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27896232/quality-of-life-perception-in-type-2-diabetes
#12
Cristian Petri, Laura Stefani, Vittorio Bini, Nicola Maffulli, Stefania Frau, Gabriele Mascherini, Massimiliano De Angelis, Giorgio Galanti
PURPOSE: Lifestyle analysis is often used for primary and secondary prevention in many chronic metabolic diseases, including diabetes. Questionnaires are simple and common methods for first investigation risk of factors related to the perception of quality of life (QoL). The present study evaluates the feasibility to use questionnaires for first investigation of risk factors, and ascertain whether the results of such questionnaires are associated with the perception of QoL. METHODS: Validated questionnaires from the international ACSM guidelines were used to study a cohort of 142 consecutive type 2 diabetes patients (mean age: 66...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27896231/prolonged-complete-hematologic-response-in-relapsed-refractory-t-large-granular-lymphocyte-leukemia-after-bendamustine-treatment
#13
R Rosamilio, V Giudice, I Ferrara, S Annunziata, L Pezzullo, G Villani, C Baldi, R Guariglia, M Rocco, C Selleri
T-large granular lymphocyte leukemia (T-LGLL) is a chronic clonal proliferation of effector memory cytotoxic CD3(+)CD57(+)CD56(-) T cells and the current guidelines suggest immunosuppressive therapy as first-line therapy, but the treatment of refractory/relapsed patients is still challenging due to the lack of prospective studies. We describe a series of two refractory/relapsed T-LGLL patients successfully treated with bendamustine, a chemotherapeutic agent largely used for B-cell neoplasms, but poorly investigated for the treatment of T-cell diseases...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27896230/evaluation-of-symptoms-and-prevention-of-cancer-in-menopause-the-value-of-vulvar-exam
#14
A R Palumbo, C Fasolino, G Santoro, V Gargano, M Rinaldi, B Arduino, M Belli, M Guida
Vulvar and vaginal atrophy (VVA), is a chronic medical condition experienced by postmenopausal women, with prevalence estimated ranging from 10% to 50% [1]. VVA is characterized by a constellation of symptoms, that may affect daily activities, sexuality, relationships, and quality of life [3]. Early recognition and effective treatment of VVA may enhance sexual health and the quality of life of women and their partners. Some vulvar conditions such as lichen sclerosus are more prevalent in the postmenopausal years...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27896229/effect-of-%C3%AE-2-adrenergic-agonists-and-antagonists-on-cytokine-release-from-human-lung-macrophages-cultured-in-vitro
#15
O Piazza, R I Staiano, E De Robertis, G Conti, V Di Crescenzo, S Loffredo, G Marone, G Zito Marinosci, M M Cataldi
The most trusted hypothesis to explain how α2-adrenergic agonists may preserve pulmonary functions in critically ill patients is that they directly act on macrophages by interfering with an autocrine/paracrine adrenergic system that controls cytokine release through locally synthetized noradrenaline and α1- and α2-adrenoreceptors. We tested this hypothesis in primary cultures of resident macrophages from human lung (HLMs). HLMs were isolated by centrifugation on percoll gradients from macroscopically healthy human lung tissue obtained from four different patients at the time of lung resection for cancer...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27896228/the-european-innovation-partnership-on-active-and-healthy-ageing-synergies-protocol-for-a-prospective-observational-study-to-measure-the-impact-of-a-community-based-program-on-prevention-and-mitigation-of-frailty-icp-pmf-in-community-dwelling-older-adults
#16
G Liotta, F Orfila, M Vollenbroek-Hutten, R Roller-Winsberger, M Illario, D Musian, S Alvino, R O'Caoimh, A Cano, W Molloy, G Iaccarino, M C Marazzi, M C Inzerilli, O Madaro, C Paul, P Csonka, A C Vince, E Menditto, M Maggio, P Scarcella, F Gilardi, F Lucaroni, P Abete, V Girardi, R Barra, L Palombi
Aim of this paper is to describe the protocol of the study "Impact of a Community-based Program on Prevention and Mitigation of Frailty in community-dwelling older adults" developed in the framework of the European Innovation Partnership on Active and Healthy Ageing. This proposal has been developed by the Partnership Action groups on frailty, fall prevention and polypharmacy in older. The proposal wants to assess the impact of community-based programs aimed to counteract three main outcomes related to frailty: hospitalization, institutionalization and death...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27896227/stress-first-single-photon-emission-computed-myocardial-perfusion-imaging
#17
C I Aquino, M Scarano, F Squame, G Casaburi, S L Nori, L Pace
BACKGROUND: Myocardial perfusion imaging (MPI) with single photon emission tomography (SPET) is widely used in coronary artery disease evaluation. Recently major dosimetric concerns have arisen. The aim of this study was to evaluate if a pre-test scoring system could predict the results of stress SPET MPI, thus avoiding two radionuclide injections. METHODS: All consecutive patients (n=309) undergoing SPET MPI during the first 6 months of 2014 constituted the study group...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27896226/use-of-the-directional-atherectomy-for-the-treatment-of-femoro-popliteal-lesions-in-patients-with-critical-lower-limb-ischemia
#18
Umberto Marcello Bracale, Gaetano Vitale, Guido Bajardi, Donatella Narese, Ettore Dinoto, Anna Maria Giribono, Doriana Ferrara, Luca Del Guercio, Massimo Midiri, Felice Pecoraro
Femoro-popliteal PTA for the treatment of critical limb ischemia is frequently associated with unsatisfactory procedural success rates while directional atherectomy (DCA) has improved success rate since claudicant patients undergoing percutaneous treatment of femoro-popliteal obstructive disease. The aim of this prospective study is to evaluate the safety, efficacy and procedural success of DCA, at one year, in the percutaneous treatment of femoro-popliteal obstructive disease in patients with critical limb ischemia...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27896225/the-urokinase-urokinase-receptor-system-in-mast-cells-effects-of-its-functional-interaction-with-fmlf-receptors
#19
Francesca Wanda Rossi, Nella Prevete, Felice Rivellese, Filomena Napolitano, Nunzia Montuori, Loredana Postiglione, Carmine Selleri, Amato de Paulis
Mast cell and basophils express the high affinity receptor for IgE (FcɛRI) and are primary effector cells of allergic disorders. The urokinase (uPA)-mediated plasminogen activation system is involved in physiological and pathological events based on cell migration and tissue remodelling, such as inflammation, wound healing, angiogenesis and metastasis. uPA is a serine protease that binds uPAR, a high affinity glycosyl-phosphatidyl-inositol (GPI)-anchored receptor. uPAR focuses uPA activity at the cell surface and activates intracellular signaling through lateral interactions with integrins, receptor tyrosine kinases and the G-protein-coupled family of fMLF chemotaxis receptors (FPRs)...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27896224/in-vitro-apoptotic-effects-of-farnesyltransferase-blockade-in-acute-myeloid-leukemia-cells
#20
V Giudice, P Ricci, L Marino, M Rocco, G Villani, M Langella, L Manente, E Seneca, I Ferrara, L Pezzullo, B Serio, C Selleri
Farnesyltransferase inhibitors (FTIs) are a class of oral anti-cancer drugs currently tested in phase I-II clinical trials for treatment of hematological malignancies. The in vitro effects of various FTIs (alpha-hydroxyfarnesylphosphonic acid, manumycin-A and SCH66336) were tested on CD34(+) KG1a cell line and in primary acute myeloid leukemia (AML) cells from 64 patients. By cell viability and clonogeneic methylcellulose assays, FTIs showed a significant inhibitory activity in CD34(+) KG1a and primary bone marrow (BM) leukemic cells from 56% of AML patients...
November 2016: Translational Medicine @ UniSa
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