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Pharmaceutical Methods

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https://www.readbyqxmd.com/read/23781491/development-and-validation-of-spectrophotometric-method-of-cefpodoxime-proxetil-using-hydrotropic-solubilizing-agents
#1
Geet Asnani, Kiran Jadhav, Dinesh Dhamecha, Ashwini Sankh, Mrityunjaya Patil
PURPOSE: To develop and validate specific and accurate UV spectrophotometric method of cefpodoxime proxetil by using different hydrotropic solubilizing agents. MATERIALS AND METHODS: The present study deals with spectrophotometric analysis of cefpodoxime proxetil by utilizing 4 different hydrotropic agents such as ammonium acetate (6 M), sodium citrate (1.25 M), sodium gycinate (1 M), sodium chloride (1 M), and urea (1 M). RESULTS: From different hydrotropic agents, urea showed best aqueous solubility of cefpodoxime proxetil...
July 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781490/validated-spectrophotometric-methods-for-the-simultaneous-determination-of-telmisartan-and-atorvastatin-in-bulk-and-tablets
#2
Kaliappan Ilango, Pushpangadhan S Shiji Kumar
AIM: Three simple, accurate, and reproducible spectrophotometric methods have been developed and validated for simultaneous estimation of telmisartan (TELM) atorvastatin (ATV) in combined tablet dosage form. MATERIALS AND METHODS: The first method is based on first-order derivative spectroscopy. The sampling wavelengths were 223 nm (zero crossing of TELM) where ATV showed considerable absorbance and 272 nm (zero crossing of ATV) where TELM showed considerable absorbance...
July 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781489/absorbance-correction-method-for-estimation-of-telmisartan-and-metoprolol-succinate-in-combined-tablet-dosage-forms
#3
Komal Patel, Amit Patel, Jayant Dave, Chaganbhai Patel
AIM AND BACKGROUND: The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of telmisartan and metoprolol succinate in combined tablet dosage form. MATERIALS AND METHODS: The method is based on the absorbance correction equations for analysis of both the drugs using methanol as solvent. Telmisartan has absorbance maxima at 296 nm and metoprolol succinate has absorbance maxima at 223 nm in methanol...
July 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781488/development-and-validation-of-a-method-for-simultaneous-estimation-of-ofloxacin-and-ornidazole-in-different-dissolution-media
#4
Dasharath M Patel, Jignesh A Soneji, Parth B Patel, Chhagan N Patel
INTRODUCTION: Ofloxacin and ornidazole in a combined tablet dosage form is available in the market. This combination has gained increasing acceptance in diarrhea caused due to bacterial and protozoal infections. Ofloxacin and ornidazole are also combined in the capsule dosage form to modify its release pattern in different studies. Spectrophotometric and HPTLC methods have been reported for their simultaneous estimation in the tablet dosage form in specific solvents. This paper presents a simple, accurate, and reproducible spectrophotometric method for simultaneous estimation of ofloxacin and ornidazole in the tablet dosage form in different dissolution media...
July 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781487/development-and-validation-of-spectrophotometric-method-for-simultaneous-estimation-of-paracetamol-and-lornoxicam-in-different-dissolution-media
#5
Dasharath M Patel, Bhavesh M Sardhara, Diglesh H Thumbadiya, Chhagan N Patel
BACKGROUND: Paracetamol and lornoxicam in combined tablet dosage form are available in the market. This combination is used to treat inflammatory diseases of the joints, osteoarthritis and sciatica. Spectrophotometric and high performance liquid chromatography (HPLC) methods have been reported for their simultaneous estimation in tablet dosage form in specific solvent. This paper presents simple, accurate and reproducible spectrophotometric method for simultaneous determination of paracetamol and lornoxicam in tablet dosage form in different dissolution media...
July 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781486/validation-of-1-methyl-2-phenylindole-method-for-estimating-lipid-peroxidation-in-the-third-instar-larvae-of-transgenic-drosophila-melanogaster-hsp70-lacz-bg-9
#6
Yasir Hasan Siddique, Smita Jyoti, Falaq Naz, Mohammad Afzal
BACKGROUND: A method using 1-methyl-2-phenylindole was developed for the estimation of lipid peroxidation in third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg (9). The method is specific for the estimation of malonaldehyde. MATERIALS AND METHODS: The larvae were exposed to 0.0025, 0.025, 0.050, and 0.100 μl/ml of cyclophosphamide for 24 and 48 h. The homogenate was prepared of the larvae tissue explant and the absorbance was noted at 586 nm...
July 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781485/development-and-validation-of-hptlc-method-for-the-determination-of-mycophenolate-mofetil-in-bulk-and-pharmaceutical-formulation
#7
S Kathirvel, K Rajendra Prasad, K Madhu Babu
AIM: Described in this manuscript is the first ever reported, new, simple, high-performance thin-layer chromatographic method for the determination of mycophenolate mofetil in bulk and tablet dosage form. MATERIALS AND METHODS: The drug was separated on aluminum plates precoated with silica gel 60 F254 with toluene, acetone, and methanol in the ratio of 6:2:2 (v/v/v) as the mobile phase. Quantitative analysis was performed by densitometric scanning at 254 nm. RESULTS: The method was validated for linearity, accuracy, precision, and robustness...
July 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781484/development-and-validation-of-a-stability-indicating-rp-hplc-method-for-simultaneous-estimation-of-olmesartan-medoxomil-and-metoprolol-succinate-in-pharmaceutical-dosage-form
#8
Nirmal M Thakker, Haresh B Panchal, Dinesh R Rakholiya, R Murugan, Vishnu P Choudhari, Bhanudas S Kuchekar
AIM AND BACKGROUND: A simple, rapid, precise and isocratic RP-HPLC (Reverse Phase High Performance Liquid Chromatography) method is aimed to develop for the simultaneous estimation of Olmesartan Medoxomil and Metoprolol Succinate in bulk drug and pharmaceutical dosage form. MATERIALS AND METHODS: The quantification is carried out using YMC-Pack CN (250 × 4.6 mm, 5.0 μm) column and the mobile phase comprises of 0.05% Trifluoro acetic acid (TFA) and Acetonitrile (ACN) (70:30 v/v)...
July 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781483/a-validated-rp-hplc-uv-method-for-quantitative-determination-of-puerarin-in-pueraria-tuberosa-dc-tuber-extract
#9
Amal K Maji, Niladri Maity, Pratim Banerji, Debdulal Banerjee
BACKGROUND: Pueraria tuberosa (Fabaceae) is a well-known medicinal herbs used in Indian traditional medicines. The puerarin is one of the most important bioactive constituent found in the tubers of this plant. Quantitative estimation of bioactive molecules is essential for the purpose of quality control and dose determination of herbal medicines. The study was designed to develop a validated reversed phase high-performance liquid chromatography (RP-HPLC) method for the quantification of puerarin in the tuber extract of P...
July 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781482/rp-hplc-method-for-simultaneous-estimation-of-tenofovir-disoproxil-fumarate-lamivudine-and-efavirenz-in-combined-tablet-dosage-form
#10
Dhara S Bhavsar, Bhavini N Patel, Chhaganbhai N Patel
BACKGROUND: A simple, precise, accurate, and rapid reverse phase-high performance liquid chromatography (RP-HPLC) method with UV-Visible detector has been developed and subsequently validated for the simultaneous determination of tenofovir disoproxil fumarate (TDF), lamivudine (LAMI), and efavirenz (EFV) in their combined tablet dosage form. MATERIALS AND METHODS: The separation was based on the use of a Kromasil C18 analytical column (150 × 4.6 mm, i.d., 5 μm)...
July 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781481/comparison-of-uv-spectrophotometry-and-high-performance-liquid-chromatography-methods-for-the-determination-of-repaglinide-in-tablets
#11
Seema M Dhole, Pramod B Khedekar, Nikhil D Amnerkar
BACKGROUND: Repaglinide is a miglitinide class of antidiabetic drug used for the treatment of type 2 diabetes mellitus. A fast and reliable method for the determination of repaglinide was highly desirable to support formulation screening and quality control. OBJECTIVE: UV spectrophotometric and reversed-phase high performance liquid chromatography (RP-HPLC) methods were developed for determination of repaglinide in the tablet dosage form. MATERIALS AND METHODS: The UV spectrum recorded between 200 400 nm using methanol as solvent and the wavelength 241 nm was selected for the determination of repaglinide...
July 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781480/estimation-of-sertraline-by-chromatographic-hplc-uv273-nm-technique-under-hydrolytic-stress-conditions
#12
Md Akhlaquer Rahman, Zeenat Iqbal, Mohd Aamir Mirza, Arshad Hussain
PURPOSE: In this paper, simple, specific and accurate RP-HPLC method was developed in order to study decomposition of sertraline (SRT) under the hydrolytic stress conditions (acid, neutral, alkaline and oxidative). MATERIALS AND METHODS: The best separation of SRT and its degradation products were achieved on reverse phase LiChoCART with Purospher (RP-18e) column. The mobile phase was composed of methanol/water (75:25, v/v). The detection wavelength was 273 nm. The method was validated and response was found to be linear in the drug concentration range of 10-200 μg ml-1 with correlation coefficient of 0...
July 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781479/rp-uplc-method-development-and-validation-for-the-simultaneous-estimation-of-ibuprofen-and-famotidine-in-pharmaceutical-dosage-form
#13
Yarram Ramakoti Reddy, Kakumani Kishore Kumar, Mrp Reddy, K Mukkanti
AIM AND BACKGROUND: A stability-indicating LC method was developed for the simultaneous determination of Ibuprofen and Famotidine in pharmaceutical dosage forms. MATERIALS AND METHODS: The chromatographic separation was achieved on Acquity UPLC BEH C-18,50 mm × 2.1 mm and 1.7 μm column with gradient elution. The mobile phase A contains a mixture of 50 mM sodium acetate buffer (pH 5.5): methanol (85:15, v/v), and the mobile phase B contains a mixture of 50 mM sodium acetate buffer (pH 5...
July 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781478/optimization-and-validation-of-spectrophotometric-methods-for-determination-of-finasteride-in-dosage-and-biological-forms
#14
Alaa S Amin, Mohammed A Kassem
AIM AND BACKGROUND: Three simple, accurate and sensitive spectrophotometric methods for the determination of finasteride in pure, dosage and biological forms, and in the presence of its oxidative degradates were developed. MATERIALS AND METHODS: These methods are indirect, involve the addition of excess oxidant potassium permanganate for method A; cerric sulfate [Ce(SO4)2] for methods B; and N-bromosuccinimide (NBS) for method C of known concentration in acid medium to finasteride, and the determination of the unreacted oxidant by measurement of the decrease in absorbance of methylene blue for method A, chromotrope 2R for method B, and amaranth for method C at a suitable maximum wavelength, λmax: 663, 528, and 520 nm, for the three methods, respectively...
January 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781477/development-and-validation-of-the-simultaneous-uv-spectrophotometric-method-for-estimation-of-metoprolol-succinate-and-olmesartan-medoxomil-in-the-tablet-dosage-form
#15
Bindi N Vora, Rajesh R Parmar, Pratik P Nayak, Dushyant A Shah
INTRODUCTION: A simple, rapid, accurate, precise, and economical UV spectrophotometric method for the simultaneous determination of metoprolol succinate (METO) and olmesartan medoxomil (OLME) in a combined tablet dosage form using the simultaneous equation method has been developed. MATERIALS AND METHODS: The method is based on the simultaneous equations for analysis of both the drugs using distilled water as a solvent. METO has absorbance maxima at 221 nm and OLME has absorbance maxima at 257 nm in distilled water...
January 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781476/uv-visible-spectrophotometric-simultaneous-estimation-of-paracetamol-and-nabumetone-by-auc-method-in-combined-tablet-dosage-form
#16
Ambadas R Rote, Prasanna A Kumbhoje, Rajendra S Bhambar
INTRODUCTION: The present study deals with development and validation of a simple, rapid, sensitive and economic area under curve method for simultaneous estimation of paracetamol and nabumetone in bulk and tablet dosage form. MATERIALS AND METHOD: Area under curve method includes determination of area of paracetamol and nabumetone at absorption maxima, which for paracetamol was 248.8 ± 10 nm and for nabumetone was 269.2 ± 10 nm. Beer's law was obeyed in the concentration range of 5-25 μg/mL for both paracetamol and nabumetone...
January 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781475/a-validated-ultra-high-pressure-liquid-chromatography-method-for-separation-of-candesartan-cilexetil-impurities-and-its-degradents-in-drug-product
#17
Namala Durga Atchuta Kumar, K Sudhakar Babu, Ullas Gosada, Nitish Sharma
INTRODUCTION: A selective, specific, and sensitive "Ultra High-Pressure Liquid Chromatography" (UPLC) method was developed for determination of candesartan cilexetil impurities as well asits degradent in tablet formulation. MATERIALS AND METHODS: The chromatographic separation was performed on Waters Acquity UPLC system and BEH Shield RP18 column using gradient elution of mobile phase A and B. 0.01 M phosphate buffer adjusted pH 3.0 with Orthophosphoric acid was used as mobile phase A and 95% acetonitrile with 5% Milli Q Water was used as mobile phase B...
January 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781474/ion-pair-spectrophotometric-estimation-of-gemifloxacin
#18
Satyabrata Sahu, Saroj Kumar Patro, Una Laxmi Narayan, Bamakanta Garnaik
INTRODUCTION: The main objective was to develop and validate a simple, accurate, precise, and sensitive ion-pair spectrophotometric extraction method for the assay of gemifloxacin mesylate (GFX) in pure, tablets and spiked human urine. MATERIALS AND METHODS: The method is based upon the reaction of gemifloxacin with methyl orange, forming a yellow-colored complex in acidic medium, which is extracted in chloroform and analyzed. The extracted complexes showed absorbance maxima (λmax) found to be at 427 nm...
January 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781473/simultaneous-determination-of-losartan-losartan-acid-and-amlodipine-in-human-plasma-by-lc-ms-ms-and-its-application-to-a-human-pharmacokinetic-study
#19
Vijaya Kumari Karra, Nageswara Rao Pilli, Jaswanth Kumar Inamadugu, J V L N Seshagiri Rao
INTRODUCTION: A simple, rapid and sensitive liquid chromatography-tandem mass spectrometric assay method has been developed and fully validated for simultaneous quantification of losartan and its active metabolite, losartan carboxylic acid, and amlodipine in human plasma. Irbesartan was used as an internal standard. MATERIALS AND METHODS: The analytes were extracted from human plasma samples by solid-phase extraction technique using Oasis HLB cartridges, (Waters Corporation, Mumbai, India)...
January 2012: Pharmaceutical Methods
https://www.readbyqxmd.com/read/23781472/development-and-validation-of-zero-and-first-order-derivative-area-under-curve-spectrophotometric-methods-for-the-determination-of-entacapone-in-bulk-material-and-in-tablets
#20
S S Chalikwar, A A Shirkhedkar, M A Bagul, P S Jain, S J Surana
AIM: The aim of this work is to establish two simple, economical, and rapid spectrophotometric methods for the quantification of entacapone in bulk material and in tablets. Further, this study is designed to validate the developed methods as per ICH guidelines. MATERIALS AND METHODS: In Methods I and II, a stock standard solution was prepared by dissolving 10 mg of entacapone in 100 mL of 10% v/v acetonitrile to obtain a concentration of 100 μg/mL. After suitable dilution, 10 μg/mL of entacapone was prepared and scanned in the UV-visible range 500-200 nm; entacapone showed a maximum absorbance at 384...
January 2012: Pharmaceutical Methods
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