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African Journal of Infectious Diseases

Herve A Kadjo, Edgard Adjogoua, Ndongo Dia, Marius Adagba, Ouattara Abdoulaye, Saraka Daniel, Bertin Kouakou, David C Ngolo, Daouda Coulibaly, Talla Nzussouo Ndahwouh, Mireille Dosso
Background: Influenza sentinel surveillance in Cote d'Ivoire showed that 70% of Acute Respiratory Infections (ARI) cases remained without etiology. This work aims to describe the epidemiological, clinical, and virological pattern of ARI that tested negative for influenza virus, in children under five years old. Materials and Methods: one thousand and fifty nine samples of patients presenting influenza Like Illness (ILI) or Severe Acute Respiratory Infections (SARI) symptoms were tested for other respiratory viruses using multiplex RT-PCR assays targeting 10 respiratory viruses...
2018: African Journal of Infectious Diseases
Nanven Abraham Maurice, Pam Dachung Luka, Magdalene Nanven Maurice, Emmanuel Ochefije Ngbede, Ponfa Nden Zhakom, Philip Paul Mshelbwala, Ishaya Sini Tekki, Utibe-Abasi Hilary Udoh, Udoh Akpan Inyang, Nsika Joseph Ekanem, Okon John Ifut, Philip A Okewole, David Shamaki, Lami Hanatu Lombin
Background: Rabies is endemic in Nigeria with clinical cases reported mainly in dogs and occasionally in livestock from all the geo-ecological zones of the country. Detection of rabies virus antigen in puppies at the age of five to ten weeks and in apparently healthy dogs shedding the virus in their saliva have been reported in some parts of Nigeria. Material and Method: This report describes a clinical rabies in a set of eight weeks old puppies confirmed by antigen detection using the direct fluorescent antibody test (DFAT), the direct rapid immunohistochemical test (DRIT), and RT-PCR...
2018: African Journal of Infectious Diseases
Nasronudin Suharto, Muhammad Amin, Diah Puspita Rini, Achmad Chusnu Romdhoni, Purwaningsih Zulfayandi Pawanis, Muhammad Syamsul Hidayat
[This corrects the article on p. 20 in vol. 12, PMID: 29302646.].
2018: African Journal of Infectious Diseases
Desak Nyoman Surya Suameitria Dewi, Soedarsono, Ni Made Mertaniasih
Background: In 2015, World Health Organization (WHO) discovered 10.4 million tuberculosis (TB) cases around the world. Multidrug-resistant tuberculosis (MDR-TB) became a threat because it has high mortality number. There were 480,000 new MDR-TB cases in 2015. Based on those problems, diagnostic development to detect M. tuberculosis rapidly and accurately is needed. The importance of detecting epitope expression of esxA full gene because there was a potential of complexity over the protein structure and might affect the protein concentration...
2018: African Journal of Infectious Diseases
Chauke T, Netshikweta L, Netshandama Vo, Nyathi L, Tshitangano Tg, Olaniyi Fc
Background: The increasing prevalence and incidence of Multi Drug Resistant Tuberculosis (MDR-TB) is as a result of the defaulting of treatment by patients. Worldwide, several factors that contribute to patients defaulting to tuberculosis treatment protocol have been identified. This paper aims to develop guidelines to minimise the defaulting rate of MDR-TB patients in MDR unit of Limpopo Province. Materials and Methods: The study was conducted using a qualitative approach...
2018: African Journal of Infectious Diseases
Raúl Montalvo, Antonio Bernabe-Ortiz, Daniela E Kirwan, Robert H Gilman
Background: The changes in body composition markers (weight, fat mass, lean mass, and BMI) over time can be associated with TB treatment outcome among HIV-infected patients. The aim of this study was to investigate whether changes in fat mass and lean mass were associated with the treatment response among patients with HIV infection and pulmonary tuberculosis. Materials and Methods: This was a prospective cohort study. Data from HIV-infected patients commencing TB therapy were analyzed...
2018: African Journal of Infectious Diseases
Devi Oktafiani, Ni Luh Ayu Megasari, Elsa Fitriana, Nasronudin, Maria Inge Lusida, Soetjipto
Background: Co-infection of human herpesvirus-8 (HHV-8) in HIV-positive people might cause Kaposi's sarcoma. Early detection of HHV-8 may prevent the onset of clinical manifestations. In Indonesia, detection of HHV-8 antigen in HIV-positive patients has yet to be reported. The intention of this research was to examine the presence of HHV-8 antigen in HIV-positive patients in East Java, Indonesia. Material and Methods: 103 serum samples were collected from HIV-positive patients in Surabaya and Tulungagung, East Java, Indonesia...
2018: African Journal of Infectious Diseases
Siti Kurniawati, Soedarsono Soedarsono, Aulanni'am Aulanni'am, Ni Made Mertaniasih
Background: Mycobacterium tuberculosis Complex (MTBC) is a group of Mycobacterium that causes tuberculosis (TB). TB is an infectious disease that remains a global health problem. Indonesia is one of the five countries in the world where TB is the most prevalent and became the country with tle second largest rate of TB in 2014 and 2015. MTBC has high pathogenicity that can cause infections in animals and humans. The most common route of transmission is via airborne droplet nuclei and contact with animals or humans infected with TB...
2018: African Journal of Infectious Diseases
Shren Chetty, Kalai Naidu
Background: Africa is profoundly stricken by the HIV pandemic. People living with HIV/AIDS are more likely to be diagnosed with psychiatric disorders than the general population. We describe the prevalence of different mood and psychiatric disorders in HIV/AIDS infected patients with serious mental illness. Materials and Methods: We retrospectively sourced data from 105 patient files, at Weskoppies Hospital, between January 2012 and December 2016. Results: 56 patients had a psychotic disorder; 27 patients had a mood disorder and three patients had a cognitive disorder...
2018: African Journal of Infectious Diseases
Bolatito Opeyemi Olopade, Clement Oluwaseun Idowu, Adesola Olaniyan Oyelese, Aaron Oladipo Aboderin
Background: Intestinal parasites are a cause of morbidity and mortality throughout the world particularly in developing countries and they are common health problems of children. This study determined the prevalence of intestinal parasites among primary school children, assessed risk factors predisposing to infection and the nutritional status with cognitive function of the pupils. Materials and Methods: It was a cross sectional study and 384 pupils from six public primary schools in Ile-Ife were enrolled...
2018: African Journal of Infectious Diseases
Adebola Onanuga, Maureen Chinelo Omeje, Darlington Deboh Eboh
Background: Urinary Tract Infections (UTIs) in pregnancy are associated with significant morbidity for both mother and baby but its early detection and treatments can prevent unfavorable complications in pregnancy. This study therefore determined the prevalence of asymptomatic bacteriuria and antimicrobial resistance profile of the urinary bacteria among pregnant women in Yenagoa, Bayelsa State, Nigeria. Materials and Methods: Mid-stream urine samples were collected from 201 apparently healthy pregnant women attending antenatal clinics in Yenagoa...
2018: African Journal of Infectious Diseases
Ali ElBakri, Lazarus Mogane, Sinda Ezzedine, Natasha Potgieter, Pascal Bessong, Raed AbuOdeh, Amidou Samie
Background: Epidemiological data on Cryptosporidium infections in the United Arab Emirates (UAE) is scarce. Therefore, the main objective of this study was to determine the prevalence of Cryptosporidium species among a community of expatriates in Sharjah, UAE working in different sectors, including the food industry, house maids and other domestic occupations. Materials and Methods: One hundred and thirty four stool samples were collected from asymptomatic individuals presenting to the Sharjah Municipality Public Health Clinic (SMPHC) for screening of intestinal parasites for work permission purposes between 2009 and 2011...
2018: African Journal of Infectious Diseases
Noor Nihad Baqer, Amel Hamzah Hammood, Khalid Falih Hassan, Elaff Saffa Al-Deen Hassan
Background: Within the past few decades, there has been an increase in the number of water-borne disease outbreaks and emergence of newly recognized waterborne parasites. Several factors which contribute to the spread of these diseases include: water, heavy rains and agricultural residues which transfer the parasites to water surface from the soil. The aim of this study was to detect the presence of parasites in the river and drinking water of Al-Wahdaa and Al-Rasheed Drinking Project and household water tanks from some regions of Baghdad...
2018: African Journal of Infectious Diseases
Emy Koestanti S, Wiwik Misaco, Sri Chusniati, Lilik Maslachah
Background: Brucellosis in pigs at East Java Indonesia has not only cause great economic losses due to a decrease in productivity of livestock but also are zoonotic. Infection on free brucelosis pigs were initially begun with the infected pigs both male and female, or the use of superior male pigs together. The elimination of the disease either on a group or population is considered as the most effective way to prevent the spread of the disease in pigs. Prevention efforts mainly addressed to vaccination, sanitary maintenace and government policy...
2018: African Journal of Infectious Diseases
Restry Sinansari, Bambang Prajogo Ew, Prihartini Widiyanti
Background: Justicia gendarussa Burm f. (Achanthaceae) has been known as traditional medicine in Indonesia. It contains of flavonoids and alkaloids. This study was conducted to evaluate the effect of J. gendarussa on the profile of IFN-γ on mice (Mus musculus ). Molecular docking test was also conducted to determine the interaction of alkaloids and flavonoids on the J. gendarussa leaves against IFN-γ receptor. It is expected that this research will provide scientific information on the development of J...
2018: African Journal of Infectious Diseases
Prihartini Widiyanti, Bambang Prajogo, Agustinus Widodo
Backgrounds: Justicia gendarussa Burm.f. has an anti-HIV activity. This study was conducted to evaluate the effects of incubation periods on the cytotoxicity and virucidal activities of the J. gendarussa leaves extract on MOLT-4 cells. Materials and Methods: The cytotoxicity assay was evaluated by using the WST-1 test with incubation periods of 3 days and 5 days. The virucidal activity test was determined by measuring the inhibitory activities on the syncytium formation...
2018: African Journal of Infectious Diseases
Desi Indriarini, Andriansjah Rukmana, Andi Yasmon
Background: Tuberculosis remains the leading cause of death in the world, especially wherever poverty, malnutrition and poor housing prevail. Mycobacterium tuberculosis Beijing strain is the most common strain that causes tuberculosis in Indonesia. The wide spread of tuberculosis has been further aggravated by HIV-AIDS and drug resistance. Unfortunately, Bacille Calmette-Guerin (BCG) as the current vaccine has different protection function and efficacy. According to function analysis, mce1A gene was predicted to have a role in host invasion and survival of Mycobacterium tuberculosis in human macrophages...
2018: African Journal of Infectious Diseases
Sri-Hidajati Bs, Sukmawati Basuki, Suhintam Pusarawati, Kusmartisnawati, Lynda Rossyanti, Sri Wijayanti Sulistyowati, Dwi Peni Kartikasari, Heny Arwati, Indah Tantular, Alpha Fardah, Andy Darma, Retno Handajani, Subijanto Marto Soedarmo
Background: Amoebiasis, the cause of dysentery and extra-intestinal abscesses, now becomes second fatal parasitic disease in the world. As routine microscopic diagnosis cannot differentiate causative Entamoeba histolytica from non-pathogenic E. dispar and E. moshkovskii , better diagnosis has to be searched. Materials and Methods: Multiplex single round PCR was tested and compared with results of microscopy of wet preparation on 30 samples of diarrheic stools and extra intestinal lesions from amoebiasis suspected patients...
2018: African Journal of Infectious Diseases
Teguh Hari Sucipto, Siti Churrotin, Harsasi Setyawati, Fahimah Martak, Kris Cahyo Mulyatno, Ilham Harlan Amarullah, Tomohiro Kotaki, Masanori Kameoka, Subagyo Yotopranoto, And Soegeng Soegijanto
Background: Dengue is a kind of infectious disease that was distributed in the tropical and sub-tropical areas. To date, there is no clinically approved dengue vaccine or antiviral for humans, even though there have been great efforts towards this end. Therefore, finding the effective compound against dengue virus (DENV) replication is very important. Among the complex compounds, copper(II)-imidazole derivatives are of interest because of their biological and medicinal benefits. Materials and Methods: In the present study, antiviral activity of [Cu(2,4,5-triphenylimidazole)2 ]n , was evaluated against different stages of dengue virus type 2 (DENV-2) replication in Vero cell using focus forming unit reduction assay and quantitative ELISA...
2018: African Journal of Infectious Diseases
Wiwied Ekasari, Tutik Sri Wahyuni, Heny Arwaty, Nindya T Putri
Background: The preliminary study on antimalarial activity of the ethanol extract of Cassia spectabilis leaves against Plasmodium berghei has been carried out by in vivo experiment. It was demonstrated that ethanol extract of C. spectabilis leaves could inhibit growth of rodent malaria parasite P. berghei by 59.29 % (at a dose of 100 mg/kg bodyweight). However, further investigation is required to determine an effective dose of the administered extract for a higher inhibitory effect and increasing effectiveness of the extract...
2018: African Journal of Infectious Diseases
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