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International Journal of Endocrinology and Metabolism

Torben Harslof, Tanja Sikjaer, Leif Mosekilde, Bente L Langdahl, Lars Rejnmark
BACKGROUND: Muscles and bones are interconnected. Recent studies suggest that undercarboxylated osteocalcin from bone may affect muscle mass and strength. There are, however, no prospective human data on this relationship. METHODS: We previously treated patients with hypoparathyroidism with intact Parathyroid Hormone (PTH) or placebo in a six-month randomized, placebo-controlled trial and demonstrated a marked increase in undercarboxylated osteocalcin (ucOC) in the PTH-treated group...
July 2016: International Journal of Endocrinology and Metabolism
Nasiroglu Narin Imga, Ozgul Ucar Elalmis, Mazhar Muslum Tuna, Bercem Aycıcek Dogan, Deniz Sahin, Dilek Berker, Serdar Guler
BACKGROUND: Emerging evidences indicate that patients diagnosed with Adrenal Incidentaloma (AI) may present cardiovascular complications. Epicardial fat thickness (EFT) has recently been described as a new risk factor and an active player in metabolic syndrome and cardiovascular disease. OBJECTIVES: We aimed to evaluate the relationship between EFT and left ventricular hypertrophy and carotid intima-media thickness, which are both strong predictors of cardiovascular morbity and mortality, in patients with nonfunctioning AI...
July 2016: International Journal of Endocrinology and Metabolism
Fatemeh Nasiri-Amiri, Afsaneh Bakhtiari, Mahbobeh Faramarzi, Hajar Adib Rad, Hajar Pasha
BACKGROUND: Gestational diabetes mellitus is one of the most common complications of pregnancy. Physical activity is associated with a lower risk of type 2 diabetes mellitus. A recent meta-analysis study suggested that more research is needed to investigate the type, duration and intensity of physical activity that can help to reduce the risk of gestational diabetes mellitus. OBJECTIVES: The present study aimed to understand the association between physical activity and gestational diabetes mellitus through comparing the type and intensity of physical activity performed by pregnant females with gestational diabetes and healthy pregnant females in the first 20 weeks of their pregnancy...
July 2016: International Journal of Endocrinology and Metabolism
Sikarin Upala, Anawin Sanguankeo, Soontharee Congrete
CONTEXT: Hypoxia reduces osteoblast growth resulting in bone thinning and osteoporosis. Although obstructive sleep apnea (OSA) with recurrent hypoxia might be a contributing factor for osteoporosis development, whether OSA is a risk or protective factor for osteoporosis has not been demonstrated. OBJECTIVES: This systematic review and meta-analysis evaluated the association between OSA and osteoporosis using published observational studies. DATA SOURCES: PubMed/MEDLINE and EMBASE databases...
July 2016: International Journal of Endocrinology and Metabolism
Khaled Rahmani, Shahin Yarahmadi, Koorosh Etemad, Ahmad Koosha, Yadollah Mehrabi, Nasrin Aghang, Hamid Soori
CONTEXT: Appropriate management of neonates, tested positive for congenital hypothyroidism (CH), in particular, the initial dosage of levothyroxine and the time of initiation of treatment is a critical issue. The aim of this study was to assess all current evidence available on the subject to ascertain the optimal initial dose and optimal initiation time of treatment for children with CH. EVIDENCE ACQUISITION: In this study, all published research related to the initiation treatment dose and the onset time of treatment in congenital hypothyroidism were reviewed...
July 2016: International Journal of Endocrinology and Metabolism
Ashrafalsadat Hakim, Ali Sadeghi Moghadam, Abdalali Shariati, Hamid Karimi, Mohamad Hossien Haghighizadeh
BACKGROUND: Diabetic foot ulcer is a worldwide health care concern affecting tens of thousands of patients. If these ulcers left untreated, they can create severe complications. OBJECTIVES: This study was designed to examine the effect of infrared radiation on the healing of diabetic foot ulcer. PATIENTS AND METHODS: This clinical trial was performed on 50 patients referred to Dr. Ganjavian hospital in Dezful city, Iran, with diabetic foot ulcer degree 1 and 2 (based on Wegener Scale)...
July 2016: International Journal of Endocrinology and Metabolism
Mahnaz Barkhordari, Mojgan Padyab, Mahsa Sardarinia, Farzad Hadaegh, Fereidoun Azizi, Mohammadreza Bozorgmanesh
BACKGROUND: A fundamental part of prevention is prediction. Potential predictors are the sine qua non of prediction models. However, whether incorporating novel predictors to prediction models could be directly translated to added predictive value remains an area of dispute. The difference between the predictive power of a predictive model with (enhanced model) and without (baseline model) a certain predictor is generally regarded as an indicator of the predictive value added by that predictor...
April 2016: International Journal of Endocrinology and Metabolism
Samaneh Asgari, Maryam Barzin, Farhad Hosseinpanah, Farzad Hadaegh, Fereidoun Azizi, Davood Khalili
BACKGROUND: Although current data shows a positive association between obesity and development of coronary heart disease (CHD) in general population, there is limited data on the important protective role of central or general obesity in patients with prevalent CHD or the "obesity paradox", from this region. OBJECTIVES: The objective of the present investigation was to describe the relationship between BMI categories and the recurrence of CHD in patients with a history of CHD using data from a large population-based study, the Tehran lipid and glucose study (TLGS)...
April 2016: International Journal of Endocrinology and Metabolism
Somayeh Atari-Hajipirloo, Neda Valizadeh, Mohammad-Hassan Khadem-Ansari, Yousef Rasmi, Fatemeh Kheradmand
BACKGROUND: The altered levels of some essential trace elements and antioxidant minerals have been observed in diabetic patients. OBJECTIVES: The aim of the present study was to compare the concentrations of essential trace elements, copper (Cu), zinc (Zn), and iron (Fe) in the serum of patients who have type 2 diabetes mellitus (T2DM) with those of their non-diabetic first-degree relatives (FDR) and control subjects. The association between glycated hemoglobin (HbA1c) and levels of metals was also evaluated...
April 2016: International Journal of Endocrinology and Metabolism
William B Horton, Jose S Subauste
CONTEXT: Type 1 diabetes mellitus (T1DM) results from a highly specific immune-mediated destruction of pancreatic β cells, resulting in chronic hyperglycemia. For many years, one of the mainstays of therapy for patients with T1DM has been exercise balanced with appropriate medications and medical nutrition. Compared to healthy peers, athletes with T1DM experience nearly all the same health-related benefits from exercise. Despite these benefits, effective management of the T1DM athlete is a constant challenge due to various concerns such as the increased risk of hypoglycemia...
April 2016: International Journal of Endocrinology and Metabolism
Marco Mele, Lars Rolighed, MarieLouise Jespersen, Lars Rejnmark, Peer Christiansen
INTRODUCTION: Cancer in the parathyroid gland is rare, but parathyroid cancer is occasionally seen in relation to genetic abnormalities. Due to a limited amount of evidence, the optimal handling of these cases is not clear. Furthermore, the presence of a malignant parathyroid tumor is rarely known at the time of the initial operation; therefore, re-operations are often necessary. The aim of this study was to present the case of a patient with a previously diagnosed jaw tumor and parathyroid carcinoma that presents as a recurrence of hyperparathyroid hypercalcemia...
April 2016: International Journal of Endocrinology and Metabolism
Mohammad Torkaman, Hassan Abolghasemi, Susan Amirsalari, Fatemeh Beiraghdar, Shahla Afsharpaiman, Zohreh Kavehmanesh, Mohammad Hossein Khosravi
BACKGROUND: Vitamin D is a vital lipid-soluble vitamin in the body, helping the growth and development of bones. Vitamin D deficiency in children has several adverse effects. The most important preventative factor is determining the deficiency at an early stage and prescribing vitamin D-containing supplements. OBJECTIVES: To investigate the vitamin D status of children younger and older than 2 years and determine the utility of prescribing vitamin D supplements...
April 2016: International Journal of Endocrinology and Metabolism
Majid Valizadeh, Zahra Piri, Farnaz Mohammadian, Koorosh Kamali, Hamid Reza Amir Moghadami
BACKGROUND: Hypovitaminosis D has been associated with the development of gestational diabetes mellitus (GDM) in many observational studies. OBJECTIVES: We report the first study of the impact of prenatal vitamin D supplementation on postpartum dysglycemia in GDM patients in a randomized clinical trial. PATIENTS AND METHODS: Women with GDM at 12 - 32 weeks of gestation were assigned randomly to either the intervention group (in which serum 25-hydroxy vitamin D [25OHD] levels were measured immediately, n = 48) or the control group (in which the serum was stored and assayed at 6 - 12 weeks post-partum, n = 48)...
April 2016: International Journal of Endocrinology and Metabolism
Sandro Gentile, Felice Strollo, Antonio Ceriello
No abstract text is available yet for this article.
April 2016: International Journal of Endocrinology and Metabolism
Somayeh Hashemi, Fahimeh Ramezani Tehrani, Nader Mohammadi, Marzieh Rostami Dovom, Farahnaz Torkestani, Masumeh Simbar, Fereidoun Azizi
BACKGROUND: Premenstrual syndrome (PMS) is reported by up to 85% of women of reproductive age. Although several studies have focused on the hormone and lipid profiles of females with PMS, the results are controversial. OBJECTIVES: This study was designed to investigate the association of hormonal and metabolic factors with PMS among Iranian women of reproductive age. MATERIALS AND METHODS: This study was a community based cross-sectional study...
April 2016: International Journal of Endocrinology and Metabolism
Hossein Moravej, Alireza Salehi, Zahra Razavi, Mahmood Reza Moein, Hamed Etemadfard, Forough Karami, Forough Ghahremani
BACKGROUND: Walnut hydrosol (WH) is used extensively by Iranian people with diabetes in order to control blood sugar (BS). There are few data regarding the effect of walnut on controlling diabetes. OBJECTIVES: A pilot study to determine the efficacy and safety of WH in patients with type 1 diabetes. MATERIALS AND METHODS: Eight patients with diabetes mellitus (DM) type 1 were enrolled in the study. They did not use any medicine except insulin...
January 2016: International Journal of Endocrinology and Metabolism
Shahram Alamdari, Atieh Amouzegar, Maryam Tohidi, Safoora Gharibzadeh, Pouyan Kheirkhah, Parnian Kheirkhah, Fereidoun Azizi
BACKGROUND: Thyroid hormones play an important role in lipid metabolism. Overt hypothyroidism is known to be associated with increased lipid profiles, but the effect of subclinical hypothyroidism (SCH) on lipid profile remains controversial. OBJECTIVES: The aim of this study was to assess the association between thyroid disorders and serum lipid levels. MATERIALS AND METHODS: The present study was conducted within the framework of Tehran lipid and glucose study (TLGS)...
January 2016: International Journal of Endocrinology and Metabolism
Yuan Hu, Xin Zhou, Dai-Hong Guo, Ping Liu
BACKGROUND: Diabetes is a metabolic disorder caused by oxidative stress and inflammation. JianYuTangKang (JYTK), as a potential Chinese integrative medicine, is an antioxidant used in Chinese medicine with potential anti-inflammatory properties. OBJECTIVES: The present randomized clinical trial was carried out to evaluate the effects of JYTK on oxidative stress and inflammation in patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: The parallel, randomized, double-blinded, placebo-controlled clinical trial included 150 newly diagnosed T2DM patients receiving metformin treatment (1...
January 2016: International Journal of Endocrinology and Metabolism
Farideh Shishehbor, Majid Mohammad Shahi, Mehdi Zarei, Azadeh Saki, Mehrnoosh Zakerkish, Fatemeh Shirani, Maryam Zare
BACKGROUND: The health benefits of pomegranate juice have been reported in several studies. However, limited clinical trials have examined the effects of concentrated pomegranate juice (CPJ) on inflammatory factors. OBJECTIVES: This study aimed to investigate the effects of CPJ on metabolic risk factors, including inflammatory biomarkers, in patients with type 2 diabetes mellitus. PATIENTS AND METHODS: In a quasi-experiment trial, 40 type 2 diabetic patients were asked to consume 50 g of CPJ daily for 4 weeks...
January 2016: International Journal of Endocrinology and Metabolism
Sima Nazarpour, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Maryam Tohidi, Fereidoun Azizi
BACKGROUND: Thyroid dysfunction is the second most common endocrine disease in females of reproductive age. There are controversial data on the adverse effect of subclinical thyroid dysfunctions on adverse feto-maternal outcomes. OBJECTIVES: The current study aimed to identify the prevalence of thyroid dysfunction during pregnancy and to assess the effectiveness of treatment with levothyroxine on pregnancy outcomes of females with thyroid autoimmunity with or without subclinical thyroid dysfunction in Tehran, Iran...
January 2016: International Journal of Endocrinology and Metabolism
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