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International Journal of Endocrinology and Metabolism

Antonio D Hidalgo-Santos, Maria Del Carmen DeMingo-Alemany, Francisca Moreno-Macián, Mónica Roselló, Carmen Orellana, Francisco Martínez, Alfonso Caro-Llopis, Sara León-Cariñena, Miguel Tomás-Vila
Introduction: Schaaf-Yang syndrome (SYS) is caused by truncating point mutations of the paternal allele of MAGEL2 , an imprinted gene located in the critical region of Prader-Willi syndrome (PWS). These patients present a phenotype with neurodevelopmental delay, hypotonia, joint contractures, and a particularly high prevalence of autism (up to 75% in affected individuals). The loss of function of MAGEL2 is suggested to contribute to endocrine hypothalamic dysfunction in individuals with PWS...
July 2018: International Journal of Endocrinology and Metabolism
Sima Nazarpour, Fahimeh Ramezani Tehrani, Maryam Rahmati, Sonia Minooee, Masoumeh Simbar, Mahsa Noroozzadeh, Fereidoun Azizi
Background: Currently, various clinical and laboratory diagnostic methods are used to detect overt hypothyroidism during pregnancy. The Billewicz scoring index, as a clinical scale for detection of hypothyroidism, has been applied in general populations; however, its application during pregnancy remains a controversial subject of ongoing research. Objectives: The purpose of this study was to evaluate the diagnostic value of Billewicz scoring index for overt hypothyroidism in a general population of Iranian pregnant women...
July 2018: International Journal of Endocrinology and Metabolism
Iraj Shahramian, Ali Bazi, Alireza Sargazi
Context: Celiac disease (CD) is a common phenomenon in children with Type 1 diabetes (T1D). In the present review, we have discussed the pathogenesis, diagnostic biomarkers, risk factors, and prognosis of CD in the context of pediatric T1D. Evidence Acquisition: Literature published in Web of Science, PubMed, Scopus, Google Scholar, and Cochrane Library were scrutinized up to the end of 2017. The keywords of celiac disease, Type 1 diabetes, children, and pediatric were used in different combinations...
July 2018: International Journal of Endocrinology and Metabolism
Shu Teng Chai, Amalina Haydar Ali Tajuddin, Norasyikin A Wahab, Norlaila Mustafa, Norlela Sukor, Nor Azmi Kamaruddin
Introduction: Ketoconazole has long been the first-line medical therapy for controlling hypercortisolism secondary to either pituitary or adrenal pathology. However, it is largely unavailable in most countries. As a result, we have turned to fluconazole as a viable alternative in view of its favourable safety profile. Case Presentation: A 50-year-old lady developed recurrent Cushing's disease after being in remission following transsphenoidal surgery (TSS) for a left pituitary microadenoma 16 years ago...
July 2018: International Journal of Endocrinology and Metabolism
Ruonan Li, Pan Hong, Hainan Lan, Xin Zheng
Background: Although growth hormone (GH) has essential roles in the growth of animals, it has no growth-promoting effect during infancy period. The molecular mechanism underlying lack of growth-promoting effect of GH during infancy period remains unclear. Important signaling pathways are mediated by GH, including Janus kinase 2 (JAK2), extracellular signal-regulated kinase 1/2 (ERK1/2), signal transducers, and activators of transcription 5, 3, and 1 (STATs 5, 3 and 1). Objectives: This study explored the underlying molecular mechanisms driving to the lack of growth-promoting effect of GH in the early stage of life by in vivo assessment of intracellular signal response (STAT5/ 3/ 1, JAK2 and ERK1/ 2) to GH at different physiological stages...
July 2018: International Journal of Endocrinology and Metabolism
Putri Ayu Jayusman, Isa Naina Mohamed, Ahmad Nazrun Shuid
Background: Gonadotropin releasing hormone (GnRH) antagonists may cause chemical castration in males by suppressing the pituitary-gonadal axis, hence reducing testosterone level. There are limited data on the effects of degarelix, a newer series of potent and long acting GnRH antagonist on bone. Objectives: The current study aimed at determining the effects of degarelix on bone turnover, bone densitometry, and bone mechanical strength in male rats. Methods: Eighteen male Sprague-Dawley rats were randomly divided into sham (SHAM), orchidectomized (ORX), and degarelix-induced (DGX) groups...
July 2018: International Journal of Endocrinology and Metabolism
Reza Taherian, Sara Jalali-Farahani, Mehrdad Karimi, Parisa Amiri, Emad Maghsoudi, Parvin Mirmiran, Fereidoun Azizi
Background: Pre-hypertension is proposed as an independent risk factor for the incidence of cardiovascular diseases. Objectives: This study aimed to explore the main factors associated with pre-hypertension via testing a hypothesized model in Tehranian adults. Methods: The study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS) between 2009 - 2011 on 4640 adults without hypertension, aged ≥ 20 years. Results: The mean age of participants was 38...
July 2018: International Journal of Endocrinology and Metabolism
Sheila Perez-Colon, Oksana Lazareva, Radhika Purushothaman, Shahid Malik, Svetlana Ten, Amrit Bhangoo
Background: Short stature in children represents a heterogeneous group with different etiologies. Primary Insulin like growth factor 1 (IGF - 1) deficiency in short stature can present with normal or elevated growth hormone (GH) production. Currently there is no model that can reliably predict response to recombinant (r)GH therapy and/or rIGF - 1 therapy in children with non - GH deficient short stature. Hypothesis: Baseline Insulin like growth factor binding protein 3 (IGFBP - 3) along with ∆ IGF - 1 in the first 3 months of GH therapy level can be a marker of growth response to the rGH and/or rIGF - 1 therapy in children with non - growth hormone deficiency short stature...
July 2018: International Journal of Endocrinology and Metabolism
Anawin Sanguankeo, Sikarin Upala
Context: Metabolic syndrome (MetS) is documented to increase the risk of mortality in the general population. However, there are reports of lower mortality in end stage renal disease (ESRD) patients with obesity. Since obesity is a major component of MetS, this meta-analysis was conducted to determine the risk of all-cause mortality, cardiovascular disease (CVD) mortality, and cardiovascular disease events (CVE) associated with MetS in ESRD subjects. Evidence Acquisition: Eligible studies from inception to March 2017 assessing the clinical outcome of MetS in ESRD subjects were comprehensively searched in MEDLINE, EMBASE, and CENTRAL...
April 2018: International Journal of Endocrinology and Metabolism
Hengameh Abdi, Fereidoun Azizi, Atieh Amouzegar
Context: Insulin can be prescribed as a monotherapy or a combined therapy with other anti-diabetic medications. In this narrative review, the authors aimed to gather data related to comparison of insulin monotherapy versus combination of insulin and other anti-diabetic treatments with regards to different outcome measures in type 2 diabetes. Evidence Acquisition: This study searched and focused on the most recently published systematic reviews and their references investigating issues related to the primary aim...
April 2018: International Journal of Endocrinology and Metabolism
Maryam Sajadi, Mahsa Noroozzadeh, Fatemeh Bagheripour, Fahimeh Ramezani Tehrani
Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women during the reproductive age. Considering disorders reported in women with PCOS, e.g. infertility, pregnancy complications (premature delivery, caesarean section and spontaneous miscarriages), and hormonal disorders, we hypothesized that uterine contractions in PCOS rats may be different from controls. We aimed to compare uterine contractions in PCOS rats with controls. Methods: Rats in the experimental group were subcutaneously injected with 5 mg of free testosterone on gestational day 20, while controls received solvent...
April 2018: International Journal of Endocrinology and Metabolism
Sepideh Soltani, Nazanin Moslehi, Firoozeh Hosseini-Esfahani, Mohammadreza Vafa
Objectives: The study aimed to investigate whether diet-induced inflammation assessed by Empirical Dietary Inflammatory Pattern (EDIP) is associated with odds of unhealthy metabolic phenotype and components of metabolic syndrome (MetS). Methods: This cross-sectional study included 403 overweight/obese individuals recruited from employees of two pharmaceutical companies in Iran. The weighted intake of 15 food groups was summed to construct EDIP and metabolic phenotypes were defined based on MetS criteria...
April 2018: International Journal of Endocrinology and Metabolism
Karimollah Hajian-Tilaki
Objectives: The aim of this study was to explore the underlying latent factors that can explain the observed variation of components of metabolic syndrome (MetS) in Iranian non-diabetic adult population. Methods: The researchers performed an exploratory factor analysis (EFA) of metabolic syndrome components, including body mass index (BMI), waist circumference (WC), systolic (SBP) and diastolic blood pressure (DBP), triglyceride (TG), high density lipoprotein (HDL), and Fasting blood sugar (FBS)...
April 2018: International Journal of Endocrinology and Metabolism
Leili Faraji Gavgani, Parvin Sarbakhsh, Mohamad Asghari Jafarabadi, Seyed Morteza Shamshirgaran, Leila Jahangiry
Background: Functional limitation is one of the most important health - related concerns of diabetic patients. This study aimed to identify the factors associated with functional limitation among diabetic patients using generalized additive model (GAM) as a flexible technique to reveal the non - linear and non - monotonic association between the response and a set of independent variables. Methods: The source data belonged to two cross - sectional studies conducted in 2014...
April 2018: International Journal of Endocrinology and Metabolism
Fatemeh Nasiri-Amiri, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Ali Montazeri, Reza Ali Mohammadpour
Background: The health related quality-of-life (HRQoL) among females with polycystic ovary syndrome (PCOS) is reduced due to emotional, psychosocial, infertility, marital, and hirsutism problems. Objectives: The current study aimed at analyzing exploratory and confirmatory factor structures of HRQoL questionnaire for polycystic ovary syndrome (PCOSQ-50) in females with PCOS in order to verify the validity of the developed instrument. Methods: The current cross validation study was conducted on females with PCOS using the PCOSQ-50...
April 2018: International Journal of Endocrinology and Metabolism
Maryam Zarkesh, Azita Zadeh-Vakili, Fereidoun Azizi, S Ahmad Fanaei, Forough Foroughi, Mehdi Hedayati
Background: Papillary thyroid cancer (PTC) is the most common endocrine malignancy. The aim of this study was to investigate the association of tissue inhibitor metalloproteinase-3 (TIMP3) mRNA and protein levels in thyroid tissues, based on BRAF V600E status with the clinicopathologic characteristics of PTC. Methods: A total of 60 fresh frozen tissue samples of PTC patients (15 male and 45 female) were collected during thyroidectomy. All clinicopathological information was obtained and samples were reviewed as well as confirmed by a pathologist; exon 15 of the BRAF gene was genotyped by sequencing, TIMP3 mRNA level was assessed using SYBR-Green Real-Time PCR, and TIMP3 protein level was measured using ELISA...
April 2018: International Journal of Endocrinology and Metabolism
Ali Bazi, Hadi Harati, Ali Khosravi-Bonjar, Elham Rakhshani, Mojtaba Delaramnasab
Background: Hypothyroidism (HT) and hypoparathyroidism (HPT) are common endocrine complications in thalassemia major (TM) patients. Objectives: In the present study, we assessed the frequency of HT and HPT in a population of TM patients in Southeast of Iran. Methods: This cross sectional study was performed on 194 TM patients in Zabol, Sistan and Baluchestan Province, Iran, during February - July 2016. The demographic, clinical, and laboratory data were collected via interviews and history - taking...
April 2018: International Journal of Endocrinology and Metabolism
Mojtaba Akbari, Akbar Soltani, Mohammad Reza Mohajeri-Tehrani, Hamidreza Aghaei Meybodi, Imaneh Sadat Mousavi Fakhr, Sayed Mahmoud Sajjadi-Jazi
Introduction: Factitious hypoglycemia, caused by the surreptitious use of insulin and sulfonylureas, is one of the most challenging differential diagnoses of hypoglycemia. Diagnosis is usually established via exclusion with respect to the special patterns of plasma insulin and C-peptide during hypoglycemic episodes. Case Presentation: We report a case of recurrent hypoglycemic episodes and confusing patterns of insulin and C-peptide levels. In the primary evaluations, insulinoma was suspected considering the high plasma concentrations of insulin and C-peptide, besides negative urine and plasma sulfonylureas during hypoglycemic episodes...
January 2018: International Journal of Endocrinology and Metabolism
Zahra Heidari, Mahmoud Ali Kaykhaei, Mahdi Jahantigh, Vahid Sheikhi
Ganglioneuroblastoma is a primary malignant tumor of the sympathetic nervous system. It usually occurs in children and is extremely rare in adults. Here, we report a case of an adrenal ganglioneuroblastoma in a 38-year-old man. The adrenal incidentaloma was surgically removed and pathologically diagnosed as a ganglioneuroblastoma. The characteristics were described, because it is an unusual tumor based on the published reports in adults. To the best of our knowledge, fewer than 50 cases of ganglioneuroblastoma and 19 cases of adrenal ganglioneuroblastoma, including this case, are reported in the literature...
January 2018: International Journal of Endocrinology and Metabolism
Arash Ordookhani, Abbas Motazedi, Kenneth D Burman
Background: The number of studies on venous thromboembolism (VTE) and thyroid cancer is very scarce and existing data are contradictory. This paper reviews VTE in thyroid cancer. Methods: The following words were used for a comprehensive literature review using MEDLINE database: Blood coagulation factors; thyroid hormones; blood coagulation tests; venous thromboembolism; receptors thyroid hormone; hemostasis; fibrinolysis; bleeding; blood coagulation disorders; thyroid neoplasms; Thyroid cancer, papillary; Thyroid cancer, follicular; Thyroid carcinoma, anaplastic; Thyroid cancer, Hurthle cell; Familial medullary thyroid carcinoma; venous thrombosis; Pulmonary embolism; Blood coagulation factors...
January 2018: International Journal of Endocrinology and Metabolism
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