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Contemporary Oncology Współczesna Onkologia

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https://www.readbyqxmd.com/read/29180936/osimertinib-effective-treatment-of-nsclc-with-activating-egfr-mutations-after-progression-on-egfr-tyrosine-kinase-inhibitors
#1
Marcin Skrzypski, Amelia Szymanowska-Narloch, Rafał Dziadziuszko
Non-small cell lung cancer (NSCLC) driven by activating mutations in epidermal growth factor receptor (EGFR) constitutes up to 10% of NSCLC cases. According to the NCCN recommendations, all patients (with the exception of smoking patients with squamous cell lung cancer) should be screened for the presence of activating EGFR mutations, i.e. deletion in exon 19 or point mutation L858R in exon 21, in order to select the group that benefits from EGFR tyrosine kinase inhibitors (EGFR TKIs) treatment. Among approved agents there are the 1st generation reversible EGFR TKIs, erlotinib and gefitinib, and the 2nd generation irreversible EGFR TKI, afatinib...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29180935/atypical-bilateral-cerebellopontine-angle-medulloblastoma-differential-diagnosis-immunohistochemical-features-and-radiological-presentation
#2
Kelvin M Piña Batista, Sayoa Alvarez de Eulate-Beramendi, María Rico, Victor Rodrigo, Yordy E Batista Batista, Kenia Y Alvarez Reyes
Medulloblastoma (MB) is a highly aggressive soft tissue neoplasm, classified as a primitive neuroectodermal tumor. It is the most common posterior fossa tumor in children, but occurs rarely in adults. MB accounts for approximately 20% of all primary central nervous system (CNS) tumors of childhood, while its incidence is around 1% of adult brain tumors. Most often it occurs in the cerebellum. We report a case of multicentric MB involving the bilateral cerebellopontine angle (CPA) and right cerebellar hemisphere...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29180934/long-term-survival-in-a-patient-with-unresectable-liver-metastases-from-uveal-melanoma-treated-with-transarterial-chemoembolization-with-irinotecan-eluting-beads-case-report-and-review-of-literature
#3
Katarzyna Stanisławska, Honorata Stadnik, Mikołaj Nawrocki, Katarzyna Ramlau-Piątek, Robert Juszkat, Michał Drews
Introduction: Treatment of unresectable liver metastases (LM) from uveal melanoma (UM) remains a major clinical challenge. Systemic chemotherapy and chemoimmunotherapy regimens extrapolated from cutaneous melanoma are considered to be ineffective in therapy of metastases from uveal melanoma. Studies suggest that the progression of hepatic metastases rather than the primary tumor or metastases in other organs determines survival. Case report: We report a case of transarterial chemoembolization of 57-year-old man diagnosed with unresectable liver metastases from uveal melanoma with irinotecan eluting beads...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29180933/implementation-of-an-enhanced-recovery-after-surgery-eras-protocol-in-a-gynaecology-department-the-follow-up-at-1-year
#4
Tomasz Nikodemski, Agnieszka Biskup, Aleksandra Taszarek, Małgorzata Albin, Anita Chudecka-Głaz, Aneta Cymbaluk-Płoska, Janusz Menkiszak
Aim of the study: An ERAS protocol provides the latest perioperative care principles, whose primary aim is to reduce complication rates, and therefore mortality. The aim of this study is to establish the progress of the ERAS pathway implementation in our gynaecology department. Material and methods: This was a retrospective analysis of two sets of 100 consecutive medical records: patients treated before (PRE-ERAS) and after (ERAS) introduction of the ERAS protocol...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29180932/assessment-of-the-accuracy-of-dose-calculation-in-the-build-up-region-of-the-tangential-field-of-the-breast-for-a-radiotherapy-treatment-planning-system
#5
Bagher Farhood, Mohammad Taghi Bahreyni Toossi, Shokouhozaman Soleymanifard, Tohid Mortezazadeh
Aim of the study: Our objective was to quantify the accuracy of dose calculation in the build-up region of the tangential field of the breast for a TiGRT treatment planning system (TPS). Material and methods: Thermoluminescent dosimeter (TLD) chips were arranged in a RANDO phantom for the dose measurement. TiGRT TPS was also used for the dose calculation. Finally, confidence limit values were obtained to quantify the accuracy of the dose calculation of the TPS at the build-up region...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29180931/treatment-results-of-adult-patients-with-primary-bone-tumours-of-the-humerus-with-the-use-of-the-oncological-modular-endoprosthesis
#6
Tomasz Goryń, Andrzej Pieńkowski, Andrzej Komor, Wirginiusz Dziewirski, Marcin Zdzienicki, Maria Kozioł, Piotr Rutkowski
Aim of the study: Primary bone tumours are relatively rare, but their diagnosis and treatment is difficult and connected with a high risk of complications. The goal of this report is a retrospective evaluation of outcomes in patients with primary tumours of the humerus treated in our centre with the use of modular endoprosthetic reconstruction. Material and methods: Currently, surgical treatment is a standard procedure for local therapy, with wide tumour-free margin resection after a planned multidisciplinary and individualised strategy of tumour management based on the diagnostic biopsy result...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29180930/examination-of-anastomotic-leak-with-aqueous-contrast-swallow-after-total-gastrectomy-should-it-be-carried-out-routinely
#7
Ulaş Aday, Ebubekir Gündeş, Hüseyin Çiyiltepe, Durmuş A Çetin, Selçuk Gülmez, Aziz S Senger, Kamuran C Değer, Mustafa Duman
Aim of the study: Examination of esophagojejunal (EJ) anastomosis with aqueous contrast swallow after total gastrectomy is still routinely conducted by many centres. The present study aimed to answer the question: Is it necessary to evaluate EJ anastomosis in terms of leakage by having every patient drink oral contrast agent before initiation of oral food intake after total gastrectomy (TG) performed due to gastric cancer? Material and methods: Clinical and radiological results of patients on whom total gastrectomy was performed due to gastric cancer between January 2013 and December 2016 were retrospectively reviewed...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29180929/estimation-of-the-prevalence-and-distribution-of-hpv-genotypes-and-identification-of-related-risk-factors-among-turkish-women
#8
Mehmet Kulhan, Nur G Kulhan, Yasemin Seven, Umit A Nayki, Cenk Nayki, Nahit Ata, Pasa Ulug
Aim of the study: The present study aims to estimate the prevalence and distribution of HPV genotypes and identify related risk factors among Turkish women. Material and methods: 11 624 Turkish women attending our gynaecological clinic and expressing a desire for access to cervical cancer screening were assessed during the years 2014-2016. Cervical specimens were collected and transported using the HC2 HPV DNA Collection Device (consisting of a cervical brush and digene Specimen Transport Medium)...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29180928/the-importance-of-serum-and-pleural-fluid-level-of-vascular-endothelial-growth-factor-vegf-and-vegf-fluid-serum-ratio-in-the-differential-diagnosis-of-malignant-mesothelioma-related-pleural-effusion
#9
Yakup Düzköprü, Zeynep Oruç, Muhammet A Kaplan, Refik Ülkü, Çetin Tanrıkulu, Derya Esmer, Ali Bırak, Mehmet Küçüköner, Zuhat Urakçı, Abdurrahman Işıkdoğan
Aim of the study: Vascular endothelial growth factor (VEGF) is one of the parameters that has been studied in differential diagnosis of malignant fluids. This study is aimed at evaluate applicability of serum, fluid VEGF level and fluid to serum VEGF ratio in the diagnosis of malignant pleural mesothelioma (MPM). Material and methods: The patients with pleural effusion over age of 18, between 2011 and 2015 were included in the study. They were divided into three groups: group 1 - mesothelioma patients; group 2 - other malignancies; and group 3 - benign aetiologies...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29180927/comparative-efficacy-of-epigallocatechin-3-gallate-against-h2o2-induced-ros-in-cervical-cancer-biopsies-and-hela-cell-lines
#10
Sohail Hussain
Aim of the study: Antioxidants play an important role in maintaining physiological homeostasis. Recent literature emphasises the potential therapeutic effects of natural antioxidants that play anti-inflammatory and antioxidant effects applicable in preventing oxidative stress-induced injury, which characterises their pathogenesis. The goal of this study was to evaluate the protective role of EGCG on the HeLa cell line and cancerous cells. Material and methods: The HeLa cell line and cervical cancer biopsies (CCB) were treated with varying doses of antioxidants to determine their effects...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29180926/radiotherapy-in-testicular-germ-cell-tumours-a-literature-review
#11
REVIEW
Joanna Jonska-Gmyrek, Piotr Peczkowski, Wojciech Michalski, Grazyna Poniatowska, Agnieszka Zolciak-Siwinska, Beata Kotowicz, Pawel Wiechno, Magdalena Golawska, Maria Kowalska, Tomasz Demkow
Testicular germ cell tumours (GCT) represent about 1-2% of malignant in men. The essential therapeutic option for early-stage GCT is radical orchiectomy (RO), except in situations that require immediate chemotherapy in patients with a massive dissemination and unequivocally elevated levels of tumour markers. Postoperative radiotherapy (PORT) in patients with testicular seminoma in Clinical Stage I (CS I) is one of the treatment options next to active surveillance (AS) and chemotherapy (CHTH). Regardless of the procedure, five-year survival in this group of patients ranges between 97% and 100%...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29180925/marjolin-s-ulcer-in-chronic-wounds-review-of-available-literature
#12
REVIEW
Dariusz Bazaliński, Joanna Przybek-Mita, Beata Barańska, Paweł Więch
Marjolin's ulcer is a rare, aggressive skin cancer developing in scar tissue, chronic ulcers and areas affected by inflammations. Its incidence is estimated to range from 1% to 2% of all burn scars. It most frequently takes the form of squamous cell carcinoma which sometimes is diagnosed during examination of lesions developing in scars and hard-to-heal chronic wounds (pressure sores, leg ulcers). Therapeutic management of Marjolin's ulcer requires well-designed treatment plan to ensure optimal medical care and good quality of life for the patient...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29180924/immune-checkpoints-their-control-by-immunotherapy-and-ovarian-cancer
#13
REVIEW
Chinmoy K Bose
Immune checkpoints are new targets for manipulation of immunological control over malignant tumors. They provide an important means to manage especially recurrent and refractory cancers and those cancers where there is an unmet need such as recurrent melanoma, renal cell carcinoma and recurrent ovarian cancer. As a new development this subject is experiencing rapid progress and multiple avenues are opening up. However, there are many hurdles to overcome, requiring constant updating, especially for students of ovarian cancer, who are looking at it with much hope...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28947891/co-existence-of-mucin-producing-urothelial-type-adenocarcinoma-of-the-prostate-and-inverted-papilloma-of-the-bladder
#14
Xiao-Nan Mu, Si-Jun Wang, Zhi-Gang Sun, Min Zhang, Zhe Li, Long-Yang Zhang
Adenocarcinoma of prostate with mucinous differentiation arising in the male urethra is extremely rare, with only 21 cases reported in the previous literature. A diagnosis of mucin-producing urothelial carcinoma of the prostate is based on the pathology, immunohistochemistry, and clinical examination by excluding the secondary adenocarcinoma of the prostate. We present a case of unexpected mucinous urothelial carcinoma of prostate with co-existing inverted papilloma of bladder in a 57-year-old man. The patient underwent transurethral resection of the prostate (TURP) and transurethral resection of a bladder tumour (TUR-Bt), and the pathologic result showed mucinous prostate carcinoma and bladder inverted papilloma...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28947890/the-prevalence-of-squamous-cell-carcinoma-in-different-sites-of-oral-cavity-at-our-rural-health-care-centre-in-loni-maharashtra-a-retrospective-10-year-study
#15
Parul Tandon, Anuj Dadhich, Harish Saluja, Shilpa Bawane, Shivani Sachdeva
AIM OF THE STUDY: Oral cancer ranks in the top three of all cancers in India and is quickly becoming a global health priority. More than 90% of oral and oropharyngeal cancers are squamous cell carcinoma. The purpose of this study was to document its incidence depending upon the involvement of different sites of oral cavity, and its variation with age and gender. MATERIAL AND METHODS: Histopathologically proven oral squamous cell carcinoma cases were collected from the department of oral and maxillofacial surgery RDC, PIMS...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28947889/laparoscopic-distal-resection-of-the-pancreas-can-be-all-resections-of-body-and-tail-of-the-pancreas-called-the-same
#16
Audrius Šileikis, Augustas Beiša, Virgilijus Beiša, Mindaugas Kvietkauskas, Marius Kryžauskas, Kęstutis Strupas
INTRODUCTION: Distal resection of the pancreas is a routine procedure in high-volume centres. However, the volume of this procedure can vary. This variation plays a very important role in laparoscopic approach of pancreatic surgery and can be a real challenge if the anatomical situation is underestimated. AIM OF THE STUDY: To present our experience in minimally invasive treatment of the pancreatic tumours and to discuss different approaches to different anatomical situations...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28947888/ct-mri-accuracy-in-detecting-and-determining-preoperative-stage-of-gastric-adenocarcinoma-in-albania
#17
Altin Malaj, Fatmir Bilaj, Albana Shahini, Marjeta Miraka
AIM OF THE STUDY: Gastric adenocarcinoma is among most frequent among cancers in Albania. Early detection and staging is helped by imaging methods, including CT and MRI. This study provides evidence on the CT and MRI accuracy in detecting and pre-operative staging of gastric adenocarcinoma in 62 patients in a diagnostic clinic in Albania. The correct staging of the gastric adenocarcinoma helps decide on the next treatment options. MATERIAL AND METHODS: Sixty-two patients with gastric adenocarcinoma, confirmed with biopsy, underwent both CT and MRI examination at a clinic in Tirana during same week...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28947887/link-between-diet-and-chemotherapy-related-gastrointestinal-side-effects
#18
Marcin Mardas, Radosław Madry, Marta Stelmach-Mardas
AIM OF THE STUDY: To evaluate an association between food products consumption, dietary intake and the incidence of selected gastrointestinal symptoms (nausea, vomiting, diarrhea and constipation) in cancer patients undergoing chemotherapy. MATERIAL AND METHODS: Fifty six women receiving chemotherapy for ovarian cancer were eligible for the study. Anthropometrical measurements were assessed. The dietary intake was evaluated by 24-hours food records. The association between the consumption of selected food products and gastrointestinal symptoms incidences was assessed by modified semi-quantitative food frequency questionnaire including 77-different food items that was developed and applied in cancer patients undergoing chemotherapy...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28947886/nutritional-status-assessment-in-colorectal-cancer-patients-qualified-to-systemic-treatment
#19
Monika Ziętarska, Joanna Krawczyk-Lipiec, Leszek Kraj, Renata Zaucha, Sylwia Małgorzewicz
AIM OF THE STUDY: Cancer is usually associated with impaired nutritional status, which is one of the factors contributing to the deterioration of the results of surgery, chemotherapy, or radiotherapy. The aim of this study was the assessment of the nutritional status of patients with CRC qualified to chemotherapy. MATERIAL AND METHODS: Seventy-five persons aged 40-86 years with colorectal cancer were examined. To evaluate the nutritional status NRS 2002, SGA, SCRINIO Working Group classification, VAS scale for appetite, and FAACT questionnaire were used...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28947885/the-safety-of-low-molecular-weight-heparins-in-the-prevention-of-venous-thromboembolism-in-surgically-treated-cancer-patients-results-of-a-multicentre-observational-study
#20
Tomasz Olesiński, Anna Fijałkowska, Andrzej Rutkowski
AIM OF THE STUDY: Despite widespread use of pharmacological prophylaxis, venous thromboembolism (VTE) still constitutes a common complication in cancer patients. The aim of the study was to analyse the safety of low-molecular-weight heparins (LMWH) in the prevention of VTE in surgically-treated cancer patients. MATERIAL AND METHODS: A total of 5207 cancer patients (44.5% men and 55.5% women) aged 16-97 years participated in a prospective observational study conducted in 13 Polish cancer centres in 2005-2008...
2017: Contemporary Oncology Współczesna Onkologia
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