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Contemporary Oncology Współczesna Onkologia

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https://www.readbyqxmd.com/read/28435404/phase-ii-study-of-adjuvant-docetaxel-and-carboplatin-with-without-doxorubicin-and-cyclophosphamide-in-triple-negative-breast-cancer-a-randomised-controlled-clinical-trial
#1
Safa Najafi, Mehrdad Payandeh, Masoud Sadeghi, Vahideh Shafaei, Fateme Shojaiyan, Fereshte Abbasvandi
AIM OF THE STUDY: The aim of this trial was to compare overall survival (OS), disease-free survival (DFS), and toxicity of two adjuvant regimens in triple negative patients with Iranian ethnicity. MATERIAL AND METHODS: In a phase II trial, patients with previously untreated triple negative breaststroke cancer were randomly assigned by using docetaxel 70 mg/m(2) and carboplatin AUC = 7 every three weeks with granulocyte colony-stimulating factor for sin courses (arm A) or doxorubicin hydrochloride 60 mg/m(2) and cyclophosphamide 600 mg/m(2) every three weeks with G-CSF for four courses followed by docetaxel 70 mg/m(2) and carboplatin AUC = 7 every three weeks with G-CSF for four courses (arm B)...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435403/comparative-analysis-of-the-incidence-of-head-and-neck-cancer-in-south-eastern-poland-and-in-poland-in-the-years-1990-2012
#2
Jan Gawełko, Marek Cierpiał-Wolan, Andrzej Kawecki, Konrad Wilk, Danuta B Pięciak-Kotlarz, Damian Sikorski
AIM OF THE STUDY: To present the changes in the incidence of cancers of the head and neck organs in south-eastern Poland and in the whole country in the years 1990-2012. MATERIAL AND METHODS: A retrospective analysis the incidence of cancers of the head and neck organs in south-eastern Poland in the years 1990-2012. Statistical methods used for cancers of ICD-10 C00-C14 and C30-C32. RESULTS: For Poland, the absolute number of cases was 123,120 in the years 1990-2012...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435402/synchronous-bilateral-testis-cancer-clinical-and-oncological-management
#3
Davide Campobasso, Stefania Ferretti, Antonio Frattini
Synchronous bilateral testis cancer (SBTC) is a rare event. It represents only 0.5-1% of all new cases of testicular cancer. Patients with this disease require careful management for psychological, oncological, and medical problems. We performed a PubMed search for all series that reported SBTC. We considered only articles in English, reporting on more than three cases. We also performed an analysis of the reported evidence regarding testosterone replacement and surgical treatment. We found 10 studies satisfying inclusion criteria for a total of 73 patients...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435401/head-and-neck-lymphomas-a-retrospective-ten-year-observation
#4
Marcelina Niemiec, Grażyna Stryjewska-Makuch, Małgorzata Janik, Bogdan Kolebacz, Grażyna Lisowska, Wojciech Ścierski
AIM OF THE STUDY: Lymphomas are a heterogeneous group of tumours of lymphoid tissue in which there is an abnormal proliferation of cells of the lymphatic system. The literature notes a gradual increase in the incidence of this type of cancer in the whole population. The aim of the study was to evaluate whether the above tendency occurs in the head and neck area. MATERIAL AND METHODS: In the years 2005-2014, at the Otolaryngology and Laryngological Oncology Department of the Upper Silesian Medical Centre in Katowice, 77 cases of lymphoma were recorded, 58 of which were analysed in terms of location, histological type, age and sex of the patient, and the presence of risk factors...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435400/neoadjuvant-sequential-chemoradiotherapy-versus-radiotherapy-alone-for-treatment-of-high-risk-extremity-soft-tissue-sarcoma-a-single-institution-experience
#5
Leyla Kılıç, Meltem Ekenel, Senem Karabulut, Fulya Ağaoğlu, Emin Darendeliler
AIM OF THE STUDY: Patients with large and high-grade extremity soft-tissue sarcoma are at significant risk for distant metastasis and sarcoma-related death. There is no randomized trial comparing chemoradiotherapy to radiotherapy in the neoadjuvant setting for high risk extremity soft-tissue sarcoma. The aim of this study is to evaluate the outcomes of patients treated with two different modalities (neoadjuvant sequential chemoradiotherapy vs. radiotherapy alone) in a single center. MATERIAL AND METHODS: Data of 67 patients were analyzed retrospectively...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435399/serum-atrial-natriuretic-peptide-a-suspected-biomarker-of-breast-cancer
#6
Maha E Houssen, Hayam F Ghazy, Kamel Farag, Mona Abo Bakr El-Hussiny, Mohamed A El Ghaffar, Sahar Alsayed Mohamed Alsayed, Omar Farouk
AIM OF THE STUDY: To assess serum levels of ANP in breast cancer female patients and its relationship to metastasis and some clinical parameters among those patients. MATERIAL AND METHODS: One hundred breast cancer patients with and without metastasis along with 20 healthy closely matched controls, were enrolled in the present cross sectional study. Background: To assess the serum levels of atrial natriuretic peptide in breast cancer Serum levels of ANP were assessed using ELISA...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435398/the-changes-of-tumour-vascular-endothelial-growth-factor-expression-after-neoadjuvant-chemoradiation-in-patients-with-rectal-adenocarcinoma
#7
David Buka, Josef Dvorak, Veronika Sitorova, Igor Sirak, Rene Voboril, Bohuslav Melichar, Igor Richter
AIM OF THE STUDY: The aim was to examine the effects of neoadjuvant chemoradiotherapy on VEGF expression in patients with locally advanced rectal cancer. MATERIALS AND METHODS: A total of 53 patients with locally advanced rectal cancer were retrospectively studied. Neoadjuvant treatment comprised external beam radiation (50.4 Gy/28 fractions) with continuous infusion of 5-fluorouracil. Four to 6 weeks after the chemoradiotherapy, the patients underwent surgical resection...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435397/leptin-receptor-q223r-polymorphism-in-egyptian-female-patients-with-breast-cancer
#8
Mona Abo-Bakr El-Hussiny, Mohmed Ali Atwa, Waleed Elnahas Rashad, Dalia A Shaheen, Nora Marzouk Elkady
AIM OF THE STUDY: Breast cancer is the most common cause of death in women. Obesity has been associated with increased risk of breast cancer in post-menopausal women. It induces chronic inflammation, which increases local and systemic levels of cytokines and adipokines such as leptin. Leptin (LEP) and leptin receptor (LEPR) genes have several polymorphisms in humans. This study aims to assess the association between blood levels of leptin and LEPR Q223R gene polymorphism in patients of cancer breast...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435396/lentivirus-mediated-knockdown-of-p27rf-rho-inhibits-hepatocellular-carcinoma-cell-growth
#9
Shuli Xie, Guangyi Wang, Guofu Chen, Mingguang Zhu, Guoyue Lv
AIM OF THE STUDY: To investigate the effects of P27RF-Rho on hepatocellular carcinoma (HCC) cell growth and explore the possibility of using it as a novel therapeutic target for liver cancer treatment. MATERIAL AND METHODS: P27RF-Rho in HCC cells was silenced by lentivirus-mediated RNA interference, and the silencing effect was verified by RT-PCR. Cell proliferation was determined by MTT and clone formation assay. Cell cycle phase and apoptosis were detected through FACS...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435395/prevention-of-pancreatic-cancer
#10
REVIEW
Stefan Kuroczycki-Saniutycz, Agnieszka Grzeszczuk, Zbigniew Wojciech Zwierz, Paweł Kołodziejczyk, Jakub Szczesiul, Beata Zalewska-Szajda, Krystyna Ościłowicz, Napoleon Waszkiewicz, Krzysztof Zwierz, Sławomir Dariusz Szajda
Pancreatic ductal adenocarcinoma (PDA) accounts for 95% of all pancreatic cancers. About 230,000 PDA cases are diagnosed worldwide each year. PDA has the lowest five-year survival rate as compared to others cancers. PDA in Poland is the fifth leading cause of death after lung, stomach, colon and breast cancer. In our paper we have analysed the newest epidemiological research, some of it controversial, to establish the best practical solution for pancreatic cancer prevention in the healthy population as well as treatment for patients already diagnosed with pancreatic cancer...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435394/the-role-of-mast-cells-in-oral-squamous-cell-carcinoma
#11
REVIEW
Swetha Gudiseva, Arvind Babu Rajendra Santosh, Raviteja Chitturi, Vamsikrishna Anumula, Chandrashekar Poosarla, Venkat Ramana Reddy Baddam
The mast cells are initial effective lineage in both humoral and adaptive immunity. They are ubiquitous in skin, mucosa, and in function. They contain biologically essential and dynamic mediators in healthy and harmful conditions of tissue. Mast cell malfunctioning could be attributed to various chronic allergic diseases. Considerately, emerging evidence of mast cell involvement in various cancers shows them to have both positive and negative roles in tumour growth. It mostly indulges in tumour progression and metastasis via angiogenesis, extracellular matrix degradation, and mitogenic activity in the tumour microenvironment...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435393/s-1-for-treatment-of-advanced-hepatocellular-carcinoma-a-systematic-review-of-the-literature
#12
REVIEW
Wu-Kui Huang, Li-Na You, Shu-Fa Yang, Deng-Yao Liu, Mo Liu, Xi-Wen Fan
Hepatocellular carcinoma (HCC) is the most common liver neoplasm worldwide. Based on its potent inhibition of dihydropyrimidine dehydrogenase (DPD), S-1 is expected to be more active than other fluoropyrimidines against HCC with DPD activity. This systematic review was aimed to assess the efficacy and safety of S-1 for treatment of advanced HCC. PubMed, the Cochrane Library, EMBA-SE, and ClinicalTrials.gov were searched using the terms "Hepatocellular Carcinoma" or "HCC" or "Hepatoma" or "Liver cancer" and ''S-1''...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435392/a-systemic-literature-review-of-neuroimaging-studies-in-women-with-breast-cancer-treated-with-adjuvant-chemotherapy
#13
REVIEW
Paulina Andryszak, Monika Wiłkość, Paweł Izdebski, Bogdan Żurawski
Chemotherapy-induced cognitive deficits in patients with breast cancer, predominantly in attention and verbal memory, have been observed in numerous studies. These neuropsychological findings are corroborated by the results of neuroimaging studies. The aim of this paper was to survey the reports on cerebral structural and functional alterations in women with breast cancer treated with chemotherapy (CTx). First, we discuss the host-related and disease-related mechanisms underlying cognitive impairment after CTx...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435391/programmed-cell-death-1-checkpoint-inhibitors-in-the-treatment-of-patients-with-advanced-melanoma
#14
REVIEW
Jacek Mackiewicz, Andrzej Mackiewicz
The treatment landscape of advanced melanoma has changed significantly following the discovery and marketing authorisation of immune checkpoints inhibitors. Ipilimumab (anti-CTLA-4) was the first one to be approved, and it. demonstrated long-term survival in about 20% of patients. Subsequently, anti-programmed cell death-1 (a-PD-1) antibodies (pembrolizuamb, nivolumab), inhibitors of PD-1/programmed cell death-1 ligand (PD1-L) synapse, showed higher clinical efficacy with lower toxicity comparing to ipilimumab...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28373827/castleman-s-disease-mimicking-lymph-node-metastases-in-a-young-woman-with-laryngeal-cancer
#15
Krystyna Serkies, Małgorzata Łazar-Poniatowska, Joanna Seredyńska, Wojciech Biernat, Jacek Jassem
Laryngeal cancer occurs rarely in adolescents and young people. Castleman's disease is a rare lymphoproliferative disorder of uncertain etiopathogenesis and heterogeneous clinicopathological forms. Involved lymph nodes and extranodal lesions in the course of Castleman's disease may mimic malignant involvement. We report a case of an 18-year-old woman with T2N0M0 laryngeal glottis cancer treated with definitive radiotherapy. During the irradiation, the patient underwent an excision of incidentally discovered left-sided enlarged cervical lymph nodes located outside the irradiated area...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28373826/axitinib-in-sequential-therapy-in-metastatic-renal-cell-carcinoma
#16
Agata Kuchar, Beata Hryciuk, Rafał Stec, Michał Mączewski, Cezary Szczylik
Efficacy of new molecularly targeted drugs in the treatment of renal cell carcinoma (RCC), confirmed in clinical studies in relation to survival and prolongation of time to progression, has became a big chance for patients with metastatic renal cell cancer. Axitinib is a potent and selective receptor tyrosine kinase for vascular endothelial growth factor (VEGFR-1, -2, -3), platelet-derived growth factor β (PDGRF-β) and c-KIT. This is a case report of a 57-year old female patient with a history of left nephrectomy due to clear cell renal cell carcinoma...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28373825/quality-of-life-in-chronic-myeloid-leukaemia-patients-after-haematopoietic-cell-transplantation-pretreated-with-second-generation-tyrosine-kinase-inhibitors
#17
Agnieszka Piekarska, Lidia Gil, Karolina Jakitowicz, Witold Prejzner, Mieczysław Komarnicki, Andrzej Hellmann
AIM OF THE STUDY: The majority of patients with chronic myeloid leukaemia (CML) respond to tyrosine kinase inhibitors (TKI), while allogeneic haematopoietic cell transplantation (HCT) is indicated in selected clinical situations. HCT carries the risk of severe complications, while the toxicity profile of dasatinib and nilotinib may lead to adverse reactions affecting the quality of life (QoL). We present the results of observational analysis of CML patients who underwent HCT after exposure to second-generation TKI (TKI2), with respect to their quality of life assessed comparatively after transplantation...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28373824/a-retrospective-evaluation-of-associations-between-chronic-obstructive-pulmonary-disease-smoking-and-efficacy-of-chemotherapy-and-selected-laboratory-parameters-in-patients-with-advanced-non-small-cell-lung-cancer
#18
Rafał Czyżykowski, Dariusz Nowak, Anna Janiak, Anna Włodarczyk, Agata Sarniak, Magdalena Krakowska, Piotr Potemski
AIM OF THE STUDY: To was to determine the impact of chronic obstructive pulmonary disease (COPD) and active smoking on the efficacy of chemotherapy and complete blood count (CBC) in patients with non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: The retrospective evaluation included 50 patients with stage IIIB-IV NSCLC, who started cisplatin-based chemotherapy. Peripheral blood CBC values were collected for testing before chemotherapy and after the first and third cycles...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28373823/the-performance-of-tele-cervicography-for-detection-of-preinvasive-and-invasive-disease-of-the-uterine-cervix-as-an-adjunctive-test-to-pap-smears
#19
Kyehyun Nam, Soo-Nyung Kim, Seung-Hyuk Sim, Seijun Han
AIM OF THE STUDY: To evaluate the diagnostic capacity of tele-cervicography for the detection of cervical neoplasia as an adjunctive test with Papanicolaou (Pap) smears. MATERIAL AND METHODS: Pap smear and tele-cervicography were performed on each subject. Histologic results were obtained for all patients. RESULTS: Of the 863 females who had a tele-cervigram, 252 (29.2%) had a positive result. Of the 60 histologically confirmed cases of high-grade squamous intraepithelial lesions (HSILs), 56 (93...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28373822/antineoplastic-chemotherapy-and-congenital-tooth-abnormalities-in-children-and-adolescents
#20
Ewa Krasuska-Sławińska, Agnieszka Brożyna, Bożenna Dembowska-Bagińska, Dorota Olczak-Kowalczyk
AIM OF THE STUDY: Chemotherapeutic treatment in children and adolescents carries a risk of congenital tooth disorders and dentinoma. Study objective is to assess the correlation between tooth abnormalities, early complications of multidrug chemotherapy, and chemotherapeutics used in different antineoplastic therapies in children and adolescents. MATERIAL AND METHODS: Enamel defects (developmental defects of enamel index - DDE index) and defects in tooth number, size, and structure were assessed clinically and radiologically in 60 patients who underwent chemotherapy on average 4...
2016: Contemporary Oncology Współczesna Onkologia
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