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Contemporary Oncology Współczesna Onkologia

Marcin Braun, Wojciech Kuncman, Leszek Teresiński, Piotr Kupnicki, Dorota Jesionek-Kupnicka, Radzislaw Kordek
Ectopic liver (EL) is a rare congenital abnormality, which is localised most commonly in the wall of the gallbladder. Histoarchitectural abnormalities, which lead to impaired transfer of blood and bile, as well as well demarcation, are characteristic features of ectopic liver nodules. Both features may explain the discrepancies between hepatocellular carcinoma (HCC) cases originating from ectopic liver in comparison to HCC cases originating from orthotopic liver: the strong propensity of ectopic liver to the development of HCC...
2017: Contemporary Oncology Współczesna Onkologia
Andrzej Bohatyrewicz, Maciej Karaczun, Daniel Kotrych, Paweł Ziętek, Łukasz Kołodziej, Alina Jurewicz
Treatment of bone metastasis is a major challenge for current and future orthopedic and oncology specialists. For the treatment of single metastases, there is a continuing search for effective local treatments that do not affect the whole patient. The current report describes the case of single breast cancer metastasis to the pelvic bone in a 50-year-old woman treated surgically by bone osteotomy combined with local doxorubicin application. The presence of cancer cells was confirmed by histopathological examination...
2017: Contemporary Oncology Współczesna Onkologia
Hamid Reza Mozaffari, Mehrdad Payandeh, Mazaher Ramezani, Masoud Sadeghi, Mohammad Mahmoudiahmadabadi, Roohollah Sharifi
Aim of the study: Herein, this meta-analysis study evaluated the efficacy of palifermin after HSCT on the incidence and severity of OM or aGVHD in hematologic malignancy patients in randomized clinical trials (RCTs). Materials and methods: To compare the efficacy of palifermin on adverse events, OM and aGVHD compared with placebo, we searched databases of PubMed/Medline, Web of Science and Cochrane Library for RCTs based on a number of criteria. Results: There was no difference observed in the incidence of OM and aGVHD between two groups...
2017: Contemporary Oncology Współczesna Onkologia
Aline Cruz, Aline Rodrigues, Amanda Ferracini, Rebeca Stahlschmidt, Nice Silva, Priscila Mazzola
This study examines whether women with breast cancer, who are adherent and non-adherent to tamoxifen, differ in their perceptions of information received during treatment. This cross-sectional study included women receiving tamoxifen as adjuvant treatment for breast cancer recruited from a teaching hospital specialised in women's health in the state of São Paulo (Brazil). Women were interviewed and their records were reviewed for socio demographic data and clinical characteristics. We assessed tamoxifen adherence using the Morisky-Green Test, and the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire - Information module (EORTC QLQ-INFO25) was used to evaluate the information received by the women...
2017: Contemporary Oncology Współczesna Onkologia
Felipe Cavagna, Anagloria Pontes, Mario Cavagna, Artur Dzik, Nilka F Donadio, Rafael Portela, Michelle T Nagai, Luiz H Gebrim
Aim of the study: The authors present a novel and specific controlled ovarian stimulation protocol for fertility preservation in women with estrogen-positive receptor breast cancer undergoing neoadjuvant chemotherapy. The protocol foresees random start ovarian stimulation and the use of letrozole associated to tamoxifen. Material and methods: Forty breast cancer patients were included in the study. COS was performed either with recombinant FSH or hMG. Concomitantly with COS, letrozole in a dose of 5 mg and tamoxifen in a dose of 20 mg were given orally on a daily basis...
2017: Contemporary Oncology Współczesna Onkologia
Piotr Rutkowski, Beata Jagielska, Jolanta Andrzejuk, Elzbieta Bylina, Iwona Lugowska, Tomasz Switaj, Hanna Kosela-Paterczyk, Katarzyna Kozak, Slawomir Falkowski, Anna Klimczak
Aim of the study: was to analyze the outcome of treatment and factors predicting results of sorafenib therapy in inoperable/metastatic CD117-positive GIST patients after failure on imatinib and sunitinib. Material and methods: We identified 60 consecutive patients (40 men, 20 women) with advanced inoperable/metastatic GIST after failure on at least imatinib and sunitinib treated in one sarcoma center with sorafenib at initial dose 2 × 400 mg daily in 2007-2015 (in 56 cases it was 3rd line therapy)...
2017: Contemporary Oncology Współczesna Onkologia
Dominika Kuleszo, Magdalena Koczkowska, Beata S Lipska-Ziętkiewicz, Wiesława Grajkowska, Elżbieta Adamkiewicz-Drożyńska, Bożenna Dembowska-Bagińska, Maciej Ciołkowski, Ewa Iżycka-Świeszewska
Aim of the study: Examination of copy number changes in a group of intracranial germ cell tumors (GCTs) with particular focus on putative aberrations of the main genes coding SHh pathway proteins. Material and methods: The study was performed on DNA isolated from fresh-frozen tumor tissue samples from eight GCTs, including six intracranial GCTs. The intracranial group consisted of three germinomas, two mature teratomas and one mixed germ cell tumor. Comparative genomic profiling analysis was carried out using microarray-CGH method (Cytosure ISCA UPD 4×180k, OGT)...
2017: Contemporary Oncology Współczesna Onkologia
Joanna Kiszkaą, Bożenna Karczmarek-Borowska
The liver is an organ that, due to vascularisation and functions, is prone to metastases. Most liver metastases are observed in cases of gastrointestinal cancers in: stomach, colon, gallbladder, and bile ducts. Metastatic lesions are also observed in lung, breast, thyroid, kidney, and pancreatic cancer. One of the best known and most effective ways of liver lesion treatment is Metastasectomy. Unfortunately, lesions are frequently inoperable. Apart from chemotherapy, it is possible to apply local treatment such as TACE (trans-arterial chemoembolisation), RFA (Radio Frequency Ablation), and SBRT (Stereotactic Body Radiation Therapy)...
2017: Contemporary Oncology Współczesna Onkologia
Kelvin Manuel Piña Batista, Kenia Yoelvi Alvarez Reyes, Fátima Pérez Lopez, Andrés Coca Pelaz, Ivan Fernandez Vega, José Luis Llorente Pendás, Antonio Saiz Ayala, Aurora Astudillo, Jorge Andrés Nuñez Rojas, Patricia Barrio Fernandez
Chordomas are rare and low-grade malignant solid tumours, despite their histologically benign appearance, that arise in the bone from embryonic notochordal vestiges of the axial skeleton, a mesoderm-derived structure that is involved in the process of neurulation and embryonic development. Chordomas occurring in the skull base tend to arise in the basiocciput along the clivus. Three major morphological variants have been described (classical, chondroid, and atypical/dedifferentiated). The pathogenesis and molecular mechanisms involved in chordoma development remain uncertain...
2017: Contemporary Oncology Współczesna Onkologia
Kacper Guglas, Marta Bogaczyńska, Tomasz Kolenda, Marcel Ryś, Anna Teresiak, Renata Bliźniak, Izabela Łasińska, Jacek Mackiewicz, Katarzyna Lamperska
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cause of cancer mortality in the world. Some progress has been made in the therapy of HNSCC, however treatment remains unsatisfactory. Recent studies have shown that different types of long non-coding RNAs (lncRNAs) are dysregulated in HNSCC and correlate with tumor progression, lymph node metastasis, clinical stage and poor prognosis. lncRNAs are a class of functional RNA molecules that can not be translated into proteins but can modulate the activity of transcription factors or regulate changes in chromatin structure...
2017: Contemporary Oncology Współczesna Onkologia
Marcin Skrzypski, Amelia Szymanowska-Narloch, Rafał Dziadziuszko
Non-small cell lung cancer (NSCLC) driven by activating mutations in epidermal growth factor receptor (EGFR) constitutes up to 10% of NSCLC cases. According to the NCCN recommendations, all patients (with the exception of smoking patients with squamous cell lung cancer) should be screened for the presence of activating EGFR mutations, i.e. deletion in exon 19 or point mutation L858R in exon 21, in order to select the group that benefits from EGFR tyrosine kinase inhibitors (EGFR TKIs) treatment. Among approved agents there are the 1st generation reversible EGFR TKIs, erlotinib and gefitinib, and the 2nd generation irreversible EGFR TKI, afatinib...
2017: Contemporary Oncology Współczesna Onkologia
Kelvin M Piña Batista, Sayoa Alvarez de Eulate-Beramendi, María Rico, Victor Rodrigo, Yordy E Batista Batista, Kenia Y Alvarez Reyes
Medulloblastoma (MB) is a highly aggressive soft tissue neoplasm, classified as a primitive neuroectodermal tumor. It is the most common posterior fossa tumor in children, but occurs rarely in adults. MB accounts for approximately 20% of all primary central nervous system (CNS) tumors of childhood, while its incidence is around 1% of adult brain tumors. Most often it occurs in the cerebellum. We report a case of multicentric MB involving the bilateral cerebellopontine angle (CPA) and right cerebellar hemisphere...
2017: Contemporary Oncology Współczesna Onkologia
Katarzyna Stanisławska, Honorata Stadnik, Mikołaj Nawrocki, Katarzyna Ramlau-Piątek, Robert Juszkat, Michał Drews
Introduction: Treatment of unresectable liver metastases (LM) from uveal melanoma (UM) remains a major clinical challenge. Systemic chemotherapy and chemoimmunotherapy regimens extrapolated from cutaneous melanoma are considered to be ineffective in therapy of metastases from uveal melanoma. Studies suggest that the progression of hepatic metastases rather than the primary tumor or metastases in other organs determines survival. Case report: We report a case of transarterial chemoembolization of 57-year-old man diagnosed with unresectable liver metastases from uveal melanoma with irinotecan eluting beads...
2017: Contemporary Oncology Współczesna Onkologia
Tomasz Nikodemski, Agnieszka Biskup, Aleksandra Taszarek, Małgorzata Albin, Anita Chudecka-Głaz, Aneta Cymbaluk-Płoska, Janusz Menkiszak
Aim of the study: An ERAS protocol provides the latest perioperative care principles, whose primary aim is to reduce complication rates, and therefore mortality. The aim of this study is to establish the progress of the ERAS pathway implementation in our gynaecology department. Material and methods: This was a retrospective analysis of two sets of 100 consecutive medical records: patients treated before (PRE-ERAS) and after (ERAS) introduction of the ERAS protocol...
2017: Contemporary Oncology Współczesna Onkologia
Bagher Farhood, Mohammad Taghi Bahreyni Toossi, Shokouhozaman Soleymanifard, Tohid Mortezazadeh
Aim of the study: Our objective was to quantify the accuracy of dose calculation in the build-up region of the tangential field of the breast for a TiGRT treatment planning system (TPS). Material and methods: Thermoluminescent dosimeter (TLD) chips were arranged in a RANDO phantom for the dose measurement. TiGRT TPS was also used for the dose calculation. Finally, confidence limit values were obtained to quantify the accuracy of the dose calculation of the TPS at the build-up region...
2017: Contemporary Oncology Współczesna Onkologia
Tomasz Goryń, Andrzej Pieńkowski, Andrzej Komor, Wirginiusz Dziewirski, Marcin Zdzienicki, Maria Kozioł, Piotr Rutkowski
Aim of the study: Primary bone tumours are relatively rare, but their diagnosis and treatment is difficult and connected with a high risk of complications. The goal of this report is a retrospective evaluation of outcomes in patients with primary tumours of the humerus treated in our centre with the use of modular endoprosthetic reconstruction. Material and methods: Currently, surgical treatment is a standard procedure for local therapy, with wide tumour-free margin resection after a planned multidisciplinary and individualised strategy of tumour management based on the diagnostic biopsy result...
2017: Contemporary Oncology Współczesna Onkologia
Ulaş Aday, Ebubekir Gündeş, Hüseyin Çiyiltepe, Durmuş A Çetin, Selçuk Gülmez, Aziz S Senger, Kamuran C Değer, Mustafa Duman
Aim of the study: Examination of esophagojejunal (EJ) anastomosis with aqueous contrast swallow after total gastrectomy is still routinely conducted by many centres. The present study aimed to answer the question: Is it necessary to evaluate EJ anastomosis in terms of leakage by having every patient drink oral contrast agent before initiation of oral food intake after total gastrectomy (TG) performed due to gastric cancer? Material and methods: Clinical and radiological results of patients on whom total gastrectomy was performed due to gastric cancer between January 2013 and December 2016 were retrospectively reviewed...
2017: Contemporary Oncology Współczesna Onkologia
Mehmet Kulhan, Nur G Kulhan, Yasemin Seven, Umit A Nayki, Cenk Nayki, Nahit Ata, Pasa Ulug
Aim of the study: The present study aims to estimate the prevalence and distribution of HPV genotypes and identify related risk factors among Turkish women. Material and methods: 11 624 Turkish women attending our gynaecological clinic and expressing a desire for access to cervical cancer screening were assessed during the years 2014-2016. Cervical specimens were collected and transported using the HC2 HPV DNA Collection Device (consisting of a cervical brush and digene Specimen Transport Medium)...
2017: Contemporary Oncology Współczesna Onkologia
Yakup Düzköprü, Zeynep Oruç, Muhammet A Kaplan, Refik Ülkü, Çetin Tanrıkulu, Derya Esmer, Ali Bırak, Mehmet Küçüköner, Zuhat Urakçı, Abdurrahman Işıkdoğan
Aim of the study: Vascular endothelial growth factor (VEGF) is one of the parameters that has been studied in differential diagnosis of malignant fluids. This study is aimed at evaluate applicability of serum, fluid VEGF level and fluid to serum VEGF ratio in the diagnosis of malignant pleural mesothelioma (MPM). Material and methods: The patients with pleural effusion over age of 18, between 2011 and 2015 were included in the study. They were divided into three groups: group 1 - mesothelioma patients; group 2 - other malignancies; and group 3 - benign aetiologies...
2017: Contemporary Oncology Współczesna Onkologia
Sohail Hussain
Aim of the study: Antioxidants play an important role in maintaining physiological homeostasis. Recent literature emphasises the potential therapeutic effects of natural antioxidants that play anti-inflammatory and antioxidant effects applicable in preventing oxidative stress-induced injury, which characterises their pathogenesis. The goal of this study was to evaluate the protective role of EGCG on the HeLa cell line and cancerous cells. Material and methods: The HeLa cell line and cervical cancer biopsies (CCB) were treated with varying doses of antioxidants to determine their effects...
2017: Contemporary Oncology Współczesna Onkologia
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