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Journal of Venomous Animals and Toxins Including Tropical Diseases

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https://www.readbyqxmd.com/read/28228775/envenomation-by-the-red-tailed-coral-snake-micrurus-mipartitus-in-colombia
#1
Carlos A Cañas, Fernando Castro-Herrera, Santiago Castaño-Valencia
BACKGROUND: Although the red-tailed coral snake (Micrurus mipartitus) is widely distributed in Colombia and its venom is highly neurotoxic and life threatening, envenomation by this species is rare. Therefore, this report may shed some light on the clinical presentation of M. mipartitus bites. CASE PRESENTATIONS: Herein, we describe two cases of patients bitten by red-tailed coral snakes, illustrating the clinical presentation of the victims, the outcomes and treatment provided...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28203248/structural-determinants-of-the-hyperalgesic-activity-of-myotoxic-lys49-phospholipase%C3%A2-a2
#2
Vanessa Olzon Zambelli, Lucimara Chioato, Vanessa Pacciari Gutierrez, Richard John Ward, Yara Cury
BACKGROUND: Bothropstoxin-I (BthTx-I) is a Lys49-phospholipase A2 (Lys49-PLA2) from the venom of Bothrops jararacussu, which despite of the lack of catalytic activity induces myotoxicity, inflammation and pain. The C-terminal region of the Lys49-PLA2s is important for these effects; however, the amino acid residues that determine hyperalgesia and edema are unknown. The aim of this study was to characterize the structural determinants for the Lys49-PLA2-induced nociception and inflammation...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28194160/highlights-in-the-knowledge-of-brown-spider-toxins
#3
REVIEW
Daniele Chaves-Moreira, Andrea Senff-Ribeiro, Ana Carolina Martins Wille, Luiza Helena Gremski, Olga Meiri Chaim, Silvio Sanches Veiga
Brown spiders are venomous arthropods that use their venom for predation and defense. In humans, bites of these animals provoke injuries including dermonecrosis with gravitational spread of lesions, hematological abnormalities and impaired renal function. The signs and symptoms observed following a brown spider bite are called loxoscelism. Brown spider venom is a complex mixture of toxins enriched in low molecular mass proteins (4-40 kDa). Characterization of the venom confirmed the presence of three highly expressed protein classes: phospholipases D, metalloproteases (astacins) and insecticidal peptides (knottins)...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28138332/erratum-to-pediatric-suppurative-parotitis-caused-by-burkholderia-pseudomallei
#4
Zengzhen Fu, Yingzi Lin, Qiang Wu, Qianfeng Xia
[This corrects the article DOI: 10.1186/s40409-016-0086-3.].
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28115922/ocellatin-peptides-from-the-skin-secretion-of-the-south-american-frog-leptodactylus-labyrinthicus-leptodactylidae-characterization-antimicrobial-activities-and-membrane-interactions
#5
Karla A G Gusmão, Daniel M Dos Santos, Virgílio M Santos, María Esperanza Cortés, Pablo V M Reis, Vera L Santos, Dorila Piló-Veloso, Rodrigo M Verly, Maria Elena de Lima, Jarbas M Resende
BACKGROUND: The availability of antimicrobial peptides from several different natural sources has opened an avenue for the discovery of new biologically active molecules. To the best of our knowledge, only two peptides isolated from the frog Leptodactylus labyrinthicus, namely pentadactylin and ocellatin-F1, have shown antimicrobial activities. Therefore, in order to explore the antimicrobial potential of this species, we have investigated the biological activities and membrane interactions of three peptides isolated from the anuran skin secretion...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28074089/antiviral-activity-of-animal-venom-peptides-and-related-compounds
#6
REVIEW
Élida Cleyse Gomes da Mata, Caroline Barbosa Farias Mourão, Marisa Rangel, Elisabeth Ferroni Schwartz
Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. Although a large number of compounds have been identified as inhibiting various viral infections and disease progression, it is urgent to achieve the discovery of more effective agents. Furthermore, proportionally to the great variety of diseases caused by viruses, very few viral vaccines are available, and not all are efficient. Thus, new antiviral substances obtained from natural products have been prospected, including those derived from venomous animals...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/27429609/cardiorespiratory-alterations-in-rodents-experimentally-envenomed-with-hadruroides-lunatus-scorpion-venom
#7
Fernanda Costal-Oliveira, Clara Guerra-Duarte, Maira Souza Oliveira, Karen Larissa Pereira de Castro, Leticia Lopes-de-Sousa, Aline Lara, Enéas Ricardo de Morais Gomes, Cesar Bonilla, Sílvia Guatimosim, Marília Martins Melo, Carlos Chávez-Olórtegui
BACKGROUND: Hadruroides lunatus is the most abundant scorpion species in the Peruvian central coast, where most of the accidents involving humans are registered. In spite of its prevalence, there are only very few studies on H. lunatus envenomation. The aim of the present study was to analyze the cardiorespiratory alterations caused by H. lunatus envenomation in rodents. METHODS: Wistar rats injected with H. lunatus scorpion venom were submitted to electrocardiography...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28031735/endogenous-phospholipase-a2-inhibitors-in-snakes-a-brief-overview
#8
REVIEW
Patrícia Cota Campos, Lutiana Amaral de Melo, Gabriel Latorre Fortes Dias, Consuelo Latorre Fortes-Dias
The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation. This inhibitor type is generally known as snake blood phospholipase A2 inhibitors (sbPLIs). Most, if not all sbPLIs are oligomeric glycosylated proteins, although the carbohydrate moiety may not be essential for PLA2 inhibition in every case. The presently known sbPLIs belong to one of three structural classes - namely sbαPLI, sbβPLI or sbγPLI - depending on the presence of characteristic C-type lectin-like domains, leucine-rich repeats or three-finger motifs, respectively...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28031734/exploring-the-in-vivo-wound-healing-effects-of-a-recombinant-hemolin-from-the-caterpillar-lonomia-obliqua
#9
Ana Claudia Sato, Rosemary Viola Bosch, Sonia Elisabete Alves Will, Miryam Paola Alvarez-Flores, Mauricio Barbugiani Goldfeder, Kerly Fernanda Mesquita Pasqualoto, Bárbara Athayde Vaz Galvão da Silva, Sonia Aparecida de Andrade, Ana Marisa Chudzinski-Tavassi
BACKGROUND: Hemolin proteins are cell adhesion molecules from lepidopterans involved in a wide range of cell interactions concerning their adhesion properties. However, hemolin's roles in cell proliferation and wound healing are not fully elucidated. It has been recently reported that rLosac, a recombinant hemolin from the caterpillar Lonomia obliqua, presents antiapoptotic activity and is capable of improving in vitro wound healing. Therefore, this study aimed to explore rLosac's in vivo effects using a skin wound healing model in rats...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28031733/a-review-on-the-scorpaena-plumieri-fish-venom-and-its-bioactive-compounds
#10
REVIEW
Fabiana V Campos, Thiago N Menezes, Pedro F Malacarne, Fábio L S Costa, Gustavo B Naumann, Helena L Gomes, Suely G Figueiredo
The most poisonous fish species found along the Brazilian coast is the spotted scorpionfish Scorpaena plumieri. Though hardly ever life-threatening to humans, envenomation by S. plumieri can be quite hazardous, provoking extreme pain and imposing significant socioeconomic costs, as the victims may require days to weeks to recover from their injuries. In this review we will walk the reader through the biological features that distinguish this species as well as the current epidemiological knowledge related to the envenomation and its consequences...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28031732/a-spider-derived-peptide-pnpp-19-induces-central-antinociception-mediated-by-opioid-and-cannabinoid-systems
#11
Daniela da Fonseca Pacheco, Ana Cristina Nogueira Freitas, Adriano Monteiro C Pimenta, Igor Dimitri Gama Duarte, Maria Elena de Lima
BACKGROUND: Some peptides purified from the venom of the spider Phoneutria nigriventer have been identified as potential sources of drugs for pain treatment. In this study, we characterized the antinociceptive effect of the peptide PnPP-19 on the central nervous system and investigated the possible involvement of opioid and cannabinoid systems in its action mechanism. METHODS: Nociceptive threshold to thermal stimulation was measured according to the tail-flick test in Swiss mice...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/27980534/melioidosis-parotitis-in-children
#12
David Dance
A recent paper published in JVATiTD reporting a child in Hainan with parotitis caused by Burkholderia pseudomallei misleadingly described parotitis as a rare manifestation of melioidosis. In fact, it is one of the commonest forms of paediatric melioidosis seen in other parts of Southeast Asia, although interestingly not in Australia.
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/27904505/composition-and-biological-activities-of-the-aqueous-extracts-of-three-scleractinian-corals-from-the-mexican-caribbean-pseudodiploria-strigosa-porites-astreoides-and-siderastrea-siderea
#13
Alejandro García-Arredondo, Alejandra Rojas-Molina, César Ibarra-Alvarado, Fernando Lazcano-Pérez, Roberto Arreguín-Espinosa, Judith Sánchez-Rodríguez
BACKGROUND: Scleractinian corals (stony corals) are the most abundant reef-forming cnidarians found in coral reefs throughout the world. Despite their abundance and ecological importance, information about the diversity of their toxins and their biological activities is very scarce. In this study, the chemical composition and the biological activities of the aqueous extracts of Pseudodiploria strigosa, Porites astreoides and Siderastrea siderea, three scleractinian corals from the Mexican Caribbean, have been assessed for the first time...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/27843446/pediatric-suppurative-parotitis-caused-by-burkholderia-pseudomallei
#14
Zengzhen Fu, Yingzi Lin, Qiang Wu, Qianfeng Xia
BACKGROUND: Suppurative parotitis caused by Burkholderia pseudomallei has been rarely found outside endemic areas. CASE PRESENTATION: Herein, we report the recovery of Burkholderia pseudomallei from the pus of a suppurative parotitis observed in a 12-year-old boy who lived in Hainan province, China. Specimens of necrotic tissue were collected and sections were stained with hematoxylin and eosin. Pus sample was also collected for bacteriological examination. The suppurative inflammation was observed in the necrotic tissue section and Burkholderia pseudomallei were detected in the sample...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/27826319/in-the-picture-disulfide-poor-conopeptides-a-class-of-pharmacologically-interesting-compounds
#15
REVIEW
Eline K M Lebbe, Jan Tytgat
During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey. This venom offers a unique and extensive source of chemical diversity as it is driven by the evolutionary pressure to improve prey capture and/or to protect their species. Cone snail venom is an example of the remarkable diversity in pharmacologically active small peptides that venoms can consist of...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/27790250/cytotoxic-activity-of-androctonus-australis-hector-venom-and-its-toxic-fractions-on-human-lung-cancer-cell-line
#16
Louisa Béchohra, Fatima Laraba-Djebari, Djelila Hammoudi-Triki
BACKGROUND: Several studies have showed that animal venoms are a source of bioactive compounds that may inhibit the growth of cancer cells, which makes them useful agents for therapeutic applications. Recently, it was established that venom toxins from scorpions induced cytotoxic, antiproliferative and apoptogenic effects on cancer cells. Therefore, the present study aims to investigate the cytotoxic activity of Androctonus australis hector (Aah) scorpion venom and its toxic fractions (FtoxG-50 and F3) on NCI-H358 human lung cancer cells...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/27790249/cloning-structural-modelling-and-characterization-of-vest2s-a-wasp-venom-hyaluronidase-haase-from-vespa-tropica
#17
Prapenpuksiri Rungsa, Paroonkorn Incamnoi, Sophida Sukprasert, Nunthawun Uawonggul, Sompong Klaynongsruang, Jureerut Daduang, Rina Patramanon, Sittiruk Roytrakul, Sakda Daduang
BACKGROUND: Wasp venom is a complex mixture containing proteins, enzymes and small molecules, including some of the most dangerous allergens. The greater banded wasp (Vespa tropica) is well-known for its lethal venom, whose one of the major components is a hyaluronidase (HAase). It is believed that the high protein proportion and activity of this enzyme is responsible for the venom potency. METHODS: In the present study, cDNA cloning, sequencing and 3D-structure of Vespa tropica venom HAase were described...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/27777582/mycobacterium-genavense-infection-in-two-species-of-captive-snakes
#18
Leila Sabrina Ullmann, Ramiro das Neves Dias-Neto, Didier Quevedo Cagnini, Ricardo Seiti Yamatogi, Jose Paes Oliveira-Filho, Viviane Nemer, Rodrigo Hidalgo Friciello Teixeira, Alexander Welker Biondo, João Pessoa Araújo
BACKGROUND: Mycobacterium is an important zoonotic agent with companion, livestock and wildlife animals reportedly playing a role as reservoirs. Although its association with reptiles has been described, the disease cycle remains to be fully established, particularly in snakes. Accordingly, this study aimed to report the occurrence of mycobacteriosis with clinical pneumonia in one exotic python snake (Python molurus) and one native green snake (Philodryas olfersii) from the Sorocaba Zoo, São Paulo state, Brazil...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/27660634/tityus-serrulatus-envenoming-in-non-obese-diabetic-mice-a-risk-factor-for-severity
#19
Guilherme Honda de Oliveira, Felipe Augusto Cerni, Iara Aimê Cardoso, Eliane Candiani Arantes, Manuela Berto Pucca
BACKGROUND: In Brazil, accidents with venomous animals are considered a public health problem. Tityus serrulatus (Ts), popularly known as the yellow scorpion, is most frequently responsible for the severe accidents in the country. Ts envenoming can cause several signs and symptoms classified according to their clinical manifestations as mild, moderate or severe. Furthermore, the victims usually present biochemical alterations, including hyperglycemia. Nevertheless, Ts envenoming and its induced hyperglycemia were never studied or documented in a patient with diabetes mellitus (DM)...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/27617022/heterologous-expression-protein-folding-and-antibody-recognition-of-a-neurotoxin-from-the-mexican-coral-snake-micrurus-laticorallis
#20
Herlinda Clement, Vianey Flores, Guillermo De la Rosa, Fernando Zamudio, Alejandro Alagon, Gerardo Corzo
BACKGROUND: The cysteine-rich neurotoxins from elapid venoms are primarily responsible for human and animal envenomation; however, their low concentration in the venom may hamper the production of efficient elapid antivenoms. Therefore, the aim of the present study was to produce fully active elapid neurotoxic immunogens for elapid antivenom production. METHOD: Cysteine-rich neurotoxins showed recombinant expression in two strains of E. coli, and were purified using affinity chromatography and reverse-phase HPLC (rpHPLC)...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
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