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Journal of Venomous Animals and Toxins Including Tropical Diseases

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https://www.readbyqxmd.com/read/29713337/alternagin-c-binding-to-%C3%AE-2-%C3%AE-1-integrin-controls-matrix-metalloprotease-9-and-matrix-metalloprotease-2-in-breast-tumor-cells-and-endothelial-cells
#1
Milene Nóbrega de Oliveira Moritz, Lívia Mara Santos Eustáquio, Kelli Cristina Micocci, Ana Carolina Caetano Nunes, Patty Karina Dos Santos, Tamires de Castro Vieira, Heloísa Sobreiro Selistre-de-Araujo
Background: Matrix metalloproteinases (MMPs) are key players in tumor progression, helping tumor cells to modify their microenvironment, which allows cell migration to secondary sites. The role of integrins, adhesion receptors that connect cells to the extracellular matrix, in MMP expression and activity has been previously suggested. However, the mechanisms by which integrins control MMP expression are not completely understood. Particularly, the role of α2β1 integrin, one of the major collagen I receptors, in MMP activity and expression has not been studied...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29692802/hemolytic-anticancer-and-antigiardial-activity-of-palythoa-caribaeorum-venom
#2
Fernando Lazcano-Pérez, Ariana Zavala-Moreno, Yadira Rufino-González, Martha Ponce-Macotela, Alejandro García-Arredondo, Miguel Cuevas-Cruz, Saúl Gómez-Manzo, Jaime Marcial-Quino, Barbarín Arreguín-Lozano, Roberto Arreguín-Espinosa
Background: Cnidarian venoms and extracts have shown a broad variety of biological activities including cytotoxic, antibacterial and antitumoral effects. Most of these studied extracts were obtained from sea anemones or jellyfish. The present study aimed to determine the toxic activity and assess the antitumor and antiparasitic potential of Palythoa caribaeorum venom by evaluating its in vitro toxicity on several models including human tumor cell lines and against the parasite Giardia intestinalis ...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29681920/combination-of-heterologous-fibrin-sealant-and-bioengineered-human-embryonic-stem-cells-to-improve-regeneration-following-autogenous-sciatic-nerve-grafting-repair
#3
Roghayeh Mozafari, Sergiy Kyrylenko, Mateus Vidigal Castro, Rui Seabra Ferreira, Benedito Barraviera, Alexandre Leite Rodrigues Oliveira
Background: Peripheral nerve injury is a worldwide clinical problem, and the preferred surgical method for treating it is the end-to-end neurorrhaphy. When it is not possible due to a large nerve gap, autologous nerve grafting is used. However, these surgical techniques result in nerve regeneration at highly variable degrees. It is thus very important to seek complementary techniques to improve motor and sensory recovery. One promising approach could be cell therapy. Transplantation therapy with human embryonic stem cells (hESCs) is appealing because these cells are pluripotent and can differentiate into specialized cell types and have self-renewal ability...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29651298/true-or-false-coral-snake-is-it-worth-the-risk-a-micrurus-corallinus-case-report
#4
Marcelo Abrahão Strauch, Guilherme Jones Souza, Jordana Nahar Pereira, Tyelli Dos Santos Ramos, Marcelo Oliveira Cesar, Marcelo Amorim Tomaz, Marcos Monteiro-Machado, Fernando Chagas Patrão-Neto, Paulo A Melo
Background: Bites provoked by the genus Micrurus represent less than 1% of snakebite cases notified in Brazil, a tiny fraction compared with other genus such as Bothrops and Crotalus , which together represent almost 80% of accidents. In addition to their less aggressive behavior, habits and morphology of coral snakes are determinant factors for such low incidence of accidents. Although Micrurus bites are rare, victims must be rescued and hospitalized in a short period of time, because this type of envenoming may evolve to a progressive muscle weakness and acute respiratory failure...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29556251/non-neurotoxic-activity-of-malayan-krait-bungarus-candidus-venom-from-thailand
#5
Mongkon Charoenpitakchai, Kulachet Wiwatwarayos, Nattapon Jaisupa, Muhamad Rusdi Ahmad Rusmili, Supachoke Mangmool, Wayne C Hodgson, Chetana Ruangpratheep, Lawan Chanhome, Janeyuth Chaisakul
Background: Envenoming by kraits (genus Bungarus ) is a medically significant issue in South Asia and Southeast Asia. Malayan krait ( Bungarus candidus ) venom is known to contain highly potent neurotoxins. In recent years, there have been reports on the non-neurotoxic activities of krait venom that include myotoxicity and nephrotoxicity. However, research on such non-neurotoxicity activities of Malayan krait venom is extremely limited. Thus, the aim of the present study was to determine the myotoxic, cytotoxic and nephrotoxic activities of B...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29507581/scorpionism-by-hemiscorpius-spp-in-iran-a-review
#6
REVIEW
Rouhullah Dehghani, Fatemeh Kamiabi, Malihe Mohammadi
Scorpions are distributed throughout Iran and the genus Hemiscorpius is particularly important in this region. Hemiscorpius lepturus is the most significant species within the genus in the country. Since scorpionism provoked by Hemiscorpius comprises a medical emergency, the present study is focused on this important issue. In order to perform the present work, a review of the medical and health-related literature was carried out in several databases. The current findings indicate that six species of Hemiscorpius are found in 15 states of Iran, mainly in the south and southwest...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29507580/antivenom-therapy-efficacy-of-premedication-for-the-prevention-of-adverse-reactions
#7
REVIEW
Victor Morais
Antivenoms or antitoxins have been effectively used for more than a century. During this time, these products have always proven to be highly effective in the treatment of infections and envenomations. However, antivenoms did not exhibit good safety results in their initial applications. After many improvements, antivenoms have substantially better safety profiles but still have some side effects. Due to the occurrence of adverse reactions, the practice of using premedication with the intent to decrease side effects has become accepted or mandatory in many countries...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29467797/peptidomic-investigation-of-neoponera-villosa-venom-by-high-resolution-mass-spectrometry-seasonal-and-nesting-habitat-variations
#8
Camila Takeno Cologna, Renata Santos Rodrigues, Jean Santos, Edwin de Pauw, Eliane Candiani Arantes, Loïc Quinton
Background: Advancements in proteomics, including the technological improvement in instrumentation, have turned mass spectrometry into an indispensable tool in the study of venoms and toxins. In addition, the advance of nanoscale liquid chromatography coupled to nanoelectrospray mass spectrometry allows, due to its high sensitivity, the study of venoms from species previously left aside, such as ants. Ant venoms are a complex mixture of compounds used for defense, predation or communication purposes...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29467796/biochemical-characterization-of-a-phospholipase-a-2-homologue-from-the-venom-of-the-social-wasp-polybia-occidentalis
#9
Rafaela Diniz-Sousa, Anderson M Kayano, Cleópatra A Caldeira, Rodrigo Simões-Silva, Marta C Monteiro, Leandro S Moreira-Dill, Fernando P Grabner, Leonardo A Calderon, Juliana P Zuliani, Rodrigo G Stábeli, Andreimar M Soares
Background: Wasp venoms constitute a molecular reservoir of new pharmacological substances such as peptides and proteins, biological property holders, many of which are yet to be identified. Exploring these sources may lead to the discovery of molecules hitherto unknown. This study describes, for the first time in hymenopteran venoms, the identification of an enzymatically inactive phospholipase A2 (PLA2 ) from the venom of the social wasp Polybia occidentalis . Methods: P...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29434634/introducing-the-consort-extension-to-pilot-trials-enhancing-the-design-conduct-and-reporting-of-pilot-or-feasibility-trials
#10
EDITORIAL
Luciana P F Abbade, Joelcio F Abbade, Lehana Thabane
No abstract text is available yet for this article.
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29410679/effects-of-brazilian-scorpion-venoms-on-the-central-nervous-system
#11
REVIEW
Ana Leonor Abrahão Nencioni, Emidio Beraldo Neto, Lucas Alves de Freitas, Valquiria Abrão Coronado Dorce
In Brazil, the scorpion species responsible for most severe incidents belong to the Tityus genus and, among this group, T. serrulatus , T. bahiensis , T. stigmurus and T. obscurus are the most dangerous ones. Other species such as T. metuendus , T. silvestres, T. brazilae , T. confluens , T. costatus , T. fasciolatus and T. neglectus are also found in the country, but the incidence and severity of accidents caused by them are lower. The main effects caused by scorpion venoms - such as myocardial damage, cardiac arrhythmias, pulmonary edema and shock - are mainly due to the release of mediators from the autonomic nervous system...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29410678/actiflagelin-a-new-sperm-activator-isolated-from-walterinnesia-aegyptia-venom-using-phenotypic-screening
#12
Tarek Mohamed Abd El-Aziz, Sawsan Al Khoury, Lucie Jaquillard, Mathilde Triquigneaux, Guillaume Martinez, Sandrine Bourgoin-Voillard, Michel Sève, Christophe Arnoult, Rémy Beroud, Michel De Waard
Background: Sperm contains a wealth of cell surface receptors and ion channels that are required for most of its basic functions such as motility and acrosome reaction. Conversely, animal venoms are enriched in bioactive compounds that primarily target those ion channels and cell surface receptors. We hypothesized, therefore, that animal venoms should be rich enough in sperm-modulating compounds for a drug discovery program. Our objective was to demonstrate this fact by using a sperm-based phenotypic screening to identify positive modulators from the venom of Walterinnesia aegyptia ...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29308066/the-evolution-and-distribution-of-noxious-species-of-scorpions-arachnida-scorpiones
#13
REVIEW
Wilson R Lourenço
This contribution attempts to bring some general information on the evolution and, in particular, on the geographic distribution of scorpion species noxious to humans. Since 95% of the scorpions incidents are generated by specimens of the family Buthidae C. L. Koch, the analysis will be limited to this familial group. As in previous similar contributions, the content of this work is mostly addressed to non-specialists whose research embraces scorpions in several fields such as venom toxins and public health...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29255475/benznidazole-affects-expression-of-th1-th17-and-treg-cytokines-during-acute-experimental-trypanosoma-cruzi-infection
#14
Mariana Gatto, Larissa Ragozo Cardoso Oliveira, Fernanda De Nuzzi Dias, João Pessoa Araújo Júnior, Carlos Roberto Gonçalves Lima, Eliana Peresi Lordelo, Rodrigo Mattos Dos Santos, Cilmery Suemi Kurokawa
Background: The present study evaluated the effect of treatment with benznidazole on mRNA expression of IFN-γ, IL-17, IL-10, TGF-β and FoxP3 in spleen and heart tissue of BALB/c mice in the acute phase of an experimental infection with Trypanosoma cruzi , strains JLP or Y. Methods: The mRNA expression of cytokines and parasite load were assessed by q -PCR. Dependent groups were compared using Student's paired t-test and independent groups were compared using Student's unpaired t-test...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29209361/-crotalus-durissus-terrificus-crotapotin-naturally-displays-preferred-positions-for-amino-acid-substitutions
#15
Laudicéia Alves de Oliveira, Rui Seabra Ferreira, Benedito Barraviera, Francilene Capel Tavares de Carvalho, Luciana Curtolo de Barros, Lucilene Delazari Dos Santos, Daniel Carvalho Pimenta
Background: Classically, Crotalus durissus terrificus (Cdt) venom can be described, according to chromatographic criteria, as a simple venom, composed of four major toxins, namely: gyroxin, crotamine, crotoxin and convulxin. Crotoxin is a non-covalent heterodimeric neurotoxin constituted of two subunits: an active phospholipase A2 and a chaperone protein, termed crotapotin. This molecule is composed of three peptide chains connected by seven disulfide bridges. Naturally occurring variants/isoforms of either crotoxin or crotapotin itself have already been reported...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29090005/the-modular-nature-of-bradykinin-potentiating-peptides-isolated-from-snake-venoms
#16
REVIEW
Juliana Mozer Sciani, Daniel Carvalho Pimenta
Bradykinin-potentiating peptides (BPPs) are molecules discovered by Sergio Ferreira - who found them in the venom of Bothrops jararaca in the 1960s - that literally potentiate the action of bradykinin in vivo by, allegedly, inhibiting the angiotensin-converting enzymes. After administration, the global physiological effect of BPP is the decrease of the blood pressure. Due to this interesting effect, one of these peptides was used by David Cushman and Miguel Ondetti to develop a hypotensive drug, the widely known captopril, vastly employed on hypertension treatment...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29075288/it-is-time-for-top-down-venomics
#17
REVIEW
Rafael D Melani, Fabio C S Nogueira, Gilberto B Domont
The protein composition of animal venoms is usually determined by peptide-centric proteomics approaches (bottom-up proteomics). However, this technique cannot, in most cases, distinguish among toxin proteoforms, herein called toxiforms , because of the protein inference problem. Top-down proteomics (TDP) analyzes intact proteins without digestion and provides high quality data to identify and characterize toxiforms. Denaturing top-down proteomics is the most disseminated subarea of TDP, which performs qualitative and quantitative analyzes of proteoforms up to ~30 kDa in high-throughput and automated fashion...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29026370/preliminary-molecular-characterization-of-a-proinflammatory-and-nociceptive-molecule-from-the-echinometra-lucunter-spines-extracts
#18
Juliana Mozer Sciani, Bianca Zychar, Luis Roberto Gonçalves, Renata Giorgi, Thiago Nogueira, Daniel Carvalho Pimenta
BACKGROUND: Sea urchins are animals commonly found on the Brazilian shoreline, being Echinometra lucunter the most abundant species. Accidents caused by E. lucunter have been reported as one of the most frequent in Brazil, and are characterized by intense pain and inflammation, consequence of spine puncture in the skin. In order to characterize such toxic effects, we isolated one molecule that caused inflammatory and nociceptive effects. METHODS: E. lucunter specimens were collected without gender distinction...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28943883/in-silico-analysis-of-binding-interaction-of-conantokins-with-nmda-receptors-for-potential-therapeutic-use-in-alzheimer-s-disease
#19
Maleeha Waqar, Sidra Batool
BACKGROUND: The N-methyl-D-aspartate (NMDA) receptors are glutamate receptors that play vital roles in central nervous system development and are involved in synaptic plasticity, which is an essential process for learning and memory. The subunit N-methyl D-aspartate receptor subtype 2B (NR2B) is the chief excitatory neurotransmitter receptor in the mammalian brain. Disturbances in the neurotransmission mediated by the NMDA receptor are caused by its overexposure to glutamate neurotransmitter and can be treated by its binding to an antagonist...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28932235/zika-virus-congenital-syndrome-experimental-models-and-clinical-aspects
#20
REVIEW
Carolina Manganeli Polonio, Carla Longo de Freitas, Nagela Ghabdan Zanluqui, Jean Pierre Schatzmann Peron
Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, dengue virus, hepatitis B and C are well known threats to human health, being responsible for many million deaths annually, associated to a huge economic and social cost. In this context, a recently introduced flavivirus in South America, called Zika virus (ZIKV), led the WHO to declare in February 1st 2016 a warning on Public Health Emergency of International Concern (PHEIC)...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
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