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BMC Hematology

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https://www.readbyqxmd.com/read/28331623/gum-arabic-as-novel-anti-oxidant-agent-in-sickle-cell-anemia-phase-ii-trial
#1
Lamis Kaddam, Imad Fadl-Elmula, Omer Ali Eisawi, Haydar Awad Abdelrazig, Mohammed Abdelraman Salih, Florian Lang, Amal M Saeed
BACKGROUND: Sickle cell anemia patients suffer from oxidative stress due to chronic inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress contributes to endothelial dysfunction, inflammation and multiple organ damage in sickle cell disease (SCD). Thus, antioxidant medication may favorably influence the disease. Gum Arabic (GA), edible, dried, gummy exudates from Acacia Senegal tree, has been claimed to act as an anti-oxidant and cytoprotective agent, protecting against experimental hepatic, renal and cardiac toxicities in rats...
2017: BMC Hematology
https://www.readbyqxmd.com/read/28184306/effect-of-malaria-infection-on-hematological-profiles-of-people-living-with-human-immunodeficiency-virus-in-gambella-southwest-ethiopia
#2
Tsion Sahle, Tilahun Yemane, Lealem Gedefaw
BACKGROUND: Malaria and human immunodeficiency virus are the two most devastating global health problems causing more than two million deaths each year. Hematological abnormalities such as anemia, thrombocytopenia and leucopenia are the common complications in malaria and HIV co-infected individuals. The aim of this study was to determine the effect of malaria infection on hematological profiles of people living with HIV attending Gambella Hospital ART clinic, Southwestern Ethiopia. OBJECTIVE: To determine the effect of malaria infection on hematological profiles of people living with HIV attending Gambella Hospital ART clinic, Southwestern Ethiopia...
2017: BMC Hematology
https://www.readbyqxmd.com/read/28174663/chronic-lymphocytic-leukemia-with-clinical-debut-as-neurological-involvement-a-rare-phenomenon-and-the-need-for-better-predictive-markers
#3
Cristhiam M Rojas-Hernandez, Jacklyn Nemunaitis, Kristopher D Marjon, Daniel Bustamante, Qian-Yun Zhang, Jennifer M Gillette
BACKGROUND: Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries. The frequency of symptomatic central nervous system (CNS) involvement is unknown but thought to be a rare phenomenon. Currently there are no known risk factors for CNS involvement. CASE PRESENTATION: We describe a clinically staged low-risk CLL case that presented with symptomatic CNS involvement and progressed rapidly to death. Evaluation of the surface adhesion molecules identified a markedly altered expression pattern of the integrin, CD49d, and the tetraspanin, CD82, in the index case when compared to similar low-risk CLL cases...
2017: BMC Hematology
https://www.readbyqxmd.com/read/28116101/prevalence-of-anemia-in-renal-insufficiency-among-hiv-infected-patients-initiating-art-at-a-hospital-in-northeast-ethiopia
#4
Temesgen Fiseha, Zemenu Tamir, Abdurahaman Seid, Wondmagegn Demsiss
BACKGROUND: Anemia is a strong predictor of mortality and poor quality of life among persons with either renal impairment or HIV infection. In this study, we investigated the prevalence of anemia and its association with renal insufficiency among HIV infected patients initiating ART at a hospital in Northeast Ethiopia. METHODS: In this retrospective cohort study, records of 373 patients on ART were selected in Dessie Referral hospital, South Wollo, Northeast Ethiopia from September 2010 to August 2013...
2017: BMC Hematology
https://www.readbyqxmd.com/read/27980789/sickle-cell-disease-in-febrile-children-living-in-a-rural-village-of-madagascar-and-association-with-malaria-and-respiratory-infections
#5
Muriel N Maeder, Henintsoa M Rabezanahary, Norosoa J Zafindraibe, Martin Raoelina Randriatiana, Tahinamandranto Rasamoelina, Andry T Rakotoarivo, Philippe Vanhems, Jonathan Hoffmann, Thomas Bénet, Mala Rakoto Andrianarivelo, Olivat A Rakoto-Alson
BACKGROUND: In Madagascar, the last study on sickle cell disease (SCD) was done in the early 1980s. The country is known as endemic for malaria and respiratory infections. The main objective of this study was to estimate the prevalence of SCD; the secondary objective was to evaluate its association with malaria and respiratory infections. METHODS: This is a cross-sectional study which was carried out in a rural village in the south east coast of Madagascar between May 2011 and November 2013...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27933177/anaemia-and-its-association-with-month-and-blood-phenotype-in-blood-donors-in-fako-division-cameroon
#6
Tebit Emmanuel Kwenti, Tayong Dizzle Bita Kwenti
BACKGROUND: Anaemia is one of the main factors in the deferral (disqualification) of blood donors following haematological screening. There is paucity of data on the prevalence of anaemia in blood donors in Sub-Saharan Africa. This study was undertaken to determine the prevalence of anaemia and its association with month and blood phenotype in blood donors in Fako division of Cameroon. METHODS: Blood donors were recruited between the 1st of January and 31st of December 2014, and their haemoglobin concentration (Hb) was determined using a haemoglobinometer...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27904750/hemophagocytic-lymphohistiocytosis-complicating-a-t-cell-rich-b-cell-lymphoma
#7
El Mehdi Mahtat, Maryem Zine, Mohamed Allaoui, Malika Kerbout, Nezha Messaoudi, Kamal Doghmi, Mohamed Mikdame
BACKGROUND: Hemophagocytic lymphohistiocytosis in adults is often secundary to an infection or a neoplasm. In this last case, T cell lymphomas are the most frequent causes. Hemophagocytic lymphohistiocytosis secundary to a B cell lymphoma has been rarely reported. CASE PRESENTATION: We describe a case of a hemophagocytic lymphohistiocytosis complicating a T-cell rich B-cell lymphoma treated with conventionnal chemotherapy leading to a complete remission. CONCLUSION: Prompt etiologic diagnosis and treatment of hemophagocytic lymphohistiocytosis leads to satisfactory outcome...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27891232/prevalence-of-transfusion-transmissible-infections-in-blood-donors-of-pakistan
#8
Aisha Arshad, Munira Borhany, Nida Anwar, Imran Naseer, Rehan Ansari, Samson Boota, Naveena Fatima, Mustansir Zaidi, Tahir Shamsi
BACKGROUND: Transfusion-transmitted infections threaten the safety of patients requiring blood transfusion, which in turn imposes serious challenges for the availability of safe blood products that are still affordable in health care systems with limited resources. The aim of the study was to determine the prevalence of transfusion-transmitted infections in blood donors and to evaluate the demographic characteristics of reactive and non-reactive blood donors. METHODS: A prospective cohort study was conducted at our institute in Karachi, Pakistan...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27833753/adherence-to-treatment-regimen-and-bleeding-rates-in-a-prospective-cohort-of-youth-and-young-adults-on-low-dose-daily-prophylaxis-for-severe-hemophilia-a
#9
Terry Mizrahi, Jean St-Louis, Nancy L Young, Francine Ménard, Nichan Zourikian, Evemie Dubé, Georges E Rivard
BACKGROUND: When availability and/or affordability of anti-hemophilic factor concentrates are limited, optimal prophylaxis regimens in severe hemophilia A (HA) remain to be determined. In selected situations, low-dose daily prophylaxis (LDDP) may be an effective and economical option. The goal of our study was to evaluate if subjects on a LDDP regimen could achieve adherence and good clinical outcome. METHODS: Seventeen subjects (age between 15.2 and 28.4) on LDDP suffering from severe/moderate HA were followed prospectively for 2 to 3 years as part of a health-related quality of life (HRQoL) study...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27708784/kir-repertory-in-patients-with-hematopoietic-diseases-and-healthy-family-members
#10
Daniele Kazue Sugioka, Carlos Eduardo Ibaldo Gonçalves, Maria da Graça Bicalho
BACKGROUND: Since the discovery of specific histocompatibility, literature has associated genes involved in the immune response, like the Human Leucocyte Antigen (HLA), with a better prognosis in transplantation. However, other non-HLA genes may also influence the immune process, such as the genes encoding the immunoglobulin-like receptors of natural killer cells (KIRs). The discovery that NK cell KIR receptors interact with conservative epitopes (C1, C2, Bw4) presented in HLA class I molecules that are genetically polymorphic, also observed in KIR genes, led to the investigation of the relevance of the KIR system to hematopoietic stem cell transplant...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27651905/deep-vein-thrombosis-resolution-recurrence-and-post-thrombotic-syndrome-a-prospective-observational-study-protocol
#11
M Bonfield, F Cramp, J Pollock
BACKGROUND: Reasons for the variation in response of deep vein thrombosis (DVT) to anticoagulation treatment are not known. Some patients develop complications such as post-thrombotic syndrome or recurrent DVT but others make a full recovery. The aim of the study is to identify the level of variation in response to anticoagulation treatment and provide more precise and quantitative disease characterisation in response to treatment. METHODS: A prospective observational study using duplex ultrasound to examine changes in thrombus characterisation, evolution and resolution over a 2 year period in patients with a confirmed DVT...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27602227/knowledge-attitude-and-practice-towards-blood-donation-and-associated-factors-among-adults-in-debre-markos-town-northwest-ethiopia
#12
Yenework Acham Jemberu, Ahmed Esmael, Kedir Y Ahmed
BACKGROUND: Although the demand for blood supply has progressively increased in developing countries, evidences indicate that there is a major shortage of blood and blood products in these countries, particularly in Ethiopia. Thus, identifying motivational factors affecting blood donation and recruitment of safe and low risk donors is necessary. For this reason, the study aimed at assessing knowledge, attitude, and practice towards blood donation and its associated factors. METHODS: A community based cross-sectional study was conducted in Debre Markos town from February to April, 2015...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27559477/anticoagulated-patient-s-perception-of-their-illness-their-beliefs-about-the-anticoagulant-therapy-prescribed-and-the-relationship-with-adherence-impact-of-novel-oral-anticoagulant-therapy-study-protocol-for-the-switching-study-a-prospective-cohort-study
#13
Vivian Auyeung, Jignesh P Patel, John K Abdou, Bipin Vadher, Lynda Bonner, Alison Brown, Lara N Roberts, Raj K Patel, Roopen Arya
BACKGROUND: Anticoagulant therapy is prescribed for millions of patients worldwide for the prevention and treatment of both arterial and venous thrombosis. Historically, only vitamin K antagonists have been available for clinicians to prescribe. The anticoagulation landscape is changing. The recent availability of the novel oral anticoagulants overcome many of the disadvantages associated with vitamin K antagonists. However the lack of formal monitoring and clinic follow-up is a concern for clinicians, as medication adherence is being assumed, which is known to decline in patients prescribed medications for chronic conditions...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27493757/a-randomized-controlled-trial-studying-the-effectiveness-of-group-medical-appointments-on-self-efficacy-and-adherence-in-sickle-cell-disease-team-study-study-protocol
#14
Marlous J Madderom, Jessica Heijdra, Elisabeth M W J Utens, Suzanne Polinder, Anita W Rijneveld, Marjon H Cnossen
BACKGROUND: Sickle cell disease (SCD) is endemic in non-Western countries. Due to migration, the prevalence of SCD in the Netherlands has increased. Adherence to medical treatment is recognized as a major problem area. Therefore, new effective interventions to increase adherence are urgently needed. METHODS/DESIGN: The TEAM study is an ongoing randomized controlled trial (RCT) to compare protocolized individual medical appointments (IMA's; care-as-usual) with protocolized group medical appointments (GMA's; novel intervention) in pediatric (n = 40) and adult (n = 60) patients...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27462400/ferumoxytol-versus-iron-sucrose-treatment-a-post-hoc-analysis-of-randomized-controlled-trials-in-patients-with-varying-renal-function-and-iron-deficiency-anemia
#15
William E Strauss, Naomi V Dahl, Zhu Li, Gloria Lau, Lee F Allen
BACKGROUND: Iron deficiency anemia is highly prevalent in patients with chronic kidney disease and is often treated with intravenous iron. There are few trials directly comparing the safety and efficacy of different intravenous iron products. METHODS: This post-hoc analysis pooled data from 767 patients enrolled in two randomized, controlled, open-label trials of similar design comparing the treatment of iron deficiency anemia with ferumoxytol and iron sucrose across patients with all stages of renal function...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27437106/chronic-epstein-barr-virus-infection-leading-to-classical-hodgkin-lymphoma
#16
Nawid M Sarwari, Joseph D Khoury, Cristhiam M Rojas Hernandez
BACKGROUND: Chronic Epstein Barr virus (EBV) infection in an immunocompetent host has been described however it is not a common entity. It has been linked to many lymphoproliferative disorders and achieves such via many molecular mechanisms, some of which are poorly understood. In addition to infectious mononucleosis, the EBV is linked to various other hematological pathologies and autoimmune disorders. CASE PRESENTATION: We describe the case of an elderly immunocompetent female who presented with non-specific symptomatology, lymphadenopathy, cytopenias, elevated autoantibody titers and a crescent EBV viral load that were suggestive of a multisystemic inflammatory disease related to EBV...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27375850/diagnostic-predictive-value-of-platelet-indices-for-discriminating-hypo-productive-versus-immune-thrombocytopenia-purpura-in-patients-attending-a-tertiary-care-teaching-hospital-in-addis-ababa-ethiopia
#17
Mikias Negash, Aster Tsegaye, Amha G/Medhin
BACKGROUND: Bone marrow examination may be required to discriminate causes of thrombocytopenia as hypoproductive or hyperdestructive. However, this procedure is invasive and time consuming. This study assessed the diagnostic value of Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and Platelet Large Cell-Ratio (P-LCR) in discriminating causes of thrombocytopenia as hypoproductive or hyperdestructive (Immune thrombocytopenia purpura). METHOD: A prospective cross-sectional study was conducted on 83 thrombocytopenic patients (Plt < 150 × 10(9)/L)...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27280023/a-systematic-review-of-using-and-reporting-survival-analyses-in-acute-lymphoblastic-leukemia-literature
#18
Chatree Chai-Adisaksopha, Alfonso Iorio, Christopher Hillis, Wendy Lim, Mark Crowther
BACKGROUNDS: Survival analysis is commonly used to determine the treatment effect among acute lymphoblastic leukemia (ALL) patients who undergo allogeneic stem cell transplantation (allo-SCT) or other treatments. The aim of this study was to evaluate the use and reporting of survival analyses in these articles. METHODS: We performed a systematic review by searching the MEDLINE, EMBASE and Cochrane library databases from inception to April 2015. Clinical trials of patients with ALL comparing allo-SCT compared to another treatment were included...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27274846/challenges-in-achieving-a-target-international-normalized-ratio-for-deep-vein-thrombosis-among-hiv-infected-patients-with-tuberculosis-a-case-series
#19
C Sekaggya, D Nalwanga, A Von Braun, R Nakijoba, A Kambugu, J Fehr, M Lamorde, B Castelnuovo
BACKGROUND: Tuberculosis (TB) and HIV are among the risk factors for deep vein thrombosis (DVT). There are several challenges in the management of DVT patients with TB-HIV co-infection including drug-drug interactions and non-adherence due to pill burden. METHODS: HIV infected patients starting treatment for TB were identified and followed up two weekly. Cases of DVT were diagnosed with Doppler ultrasound and patients were initiated on oral anticoagulation with warfarin and followed up with repeated INR measurements and warfarin dose adjustment...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27213048/prevalence-of-neutropenia-in-children-by-nationality
#20
Srdjan Denic, Hassib Narchi, Lolowa A Al Mekaini, Suleiman Al-Hammadi, Omar N Al Jabri, Abdul-Kader Souid
BACKGROUND: A high prevalence of neutropenia has been reported in several ethnic groups amongst whom many healthy individuals with low neutrophil counts undergo unnecessary investigations. This study aims to ascertain the prevalence of neutropenia (NP) in a large cohort of children from North African, Middle Eastern, and Asian countries residing in the United Arab Emirates. METHODS: Neutrophil counts of 26,542 children (one day to six years of age) from 86 countries were analyzed...
2016: BMC Hematology
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