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BMC Hematology

Nurfatin Mohd Shah, Soon Eu Chong, Syahirah Mohamed Yusoff, Mohd Zulfakar Mazlan, Khairul Bariah Johan, Nizuwan Azman, Jo Anne Lim, Siti Mardhiana Mohamad, Siti Salmah Noordin, Zainab Abdul Ghaffar, Mohd Hasyizan Hassan, Muhammad Azrul Zabidi, Nur Arzuar Abdul Rahim
Background: Massive bleeding is one of the commonest salvageable causes of death. The search for an ideal haemostatic agent during massive bleeding is still ongoing. One of the novel haemostatic medications is recombinant activated factor VII (rFVIIa). To date, the usage of rFVIIa during massive haemorrhage among non-haemophiliac patients remains off-label. The aim of this study is to report our experience in using rFVIIa to treat refractory bleeding. Methods: Medical records of all patients treated with rFVIIa for massive bleeding over an eleven-year period in a single institution were recorded...
2018: BMC Hematology
Julie Makani, Furahini Tluway, Abel Makubi, Deogratius Soka, Siana Nkya, Raphael Sangeda, Josephine Mgaya, Stella Rwezaula, Fenella J Kirkham, Christina Kindole, Elisha Osati, Elineema Meda, Robert W Snow, Charles R Newton, David Roberts, Muhsin Aboud, Swee Lay Thein, Sharon E Cox, Lucio Luzzatto, Bruno P Mmbando
Background: Africa has the highest burden of Sickle cell disease (SCD) but there are few large, systematic studies providing reliable descriptions of the disease spectrum. Tanzania, with 11,000 SCD births annually, established the Muhimbili Sickle Cell program aiming to improve understanding of SCD in Africa. We report the profile of SCD seen in the first 10 years at Muhimbili National Hospital (MNH). Methods: Individuals seen at MNH known or suspected to have SCD were enrolled at clinic and laboratory testing for SCD, haematological and biochemical analyses done...
2018: BMC Hematology
Ayenew Negesse, Temesgen Getaneh, Habtamu Temesgen, Tesfahun Taddege, Dube Jara, Zeleke Abebaw
Background: Anemia is a common hematologic disorder among human Immunodeficiency virus (HIV) infected adult Individuals. However, there is no concrete scientific evidence established at national level in Ethiopia. Hence, this review gave special emphasis on Ethiopian HIV infected adult individuals to estimate pooled prevalence of anemia and its associated factors at national level. Methods: Studies were retrieved through search engines in PUBMED/Medline, Cochrane Library, and the web of science, Google and Google scholar following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P)...
2018: BMC Hematology
Ishag Adam, Yassin Ibrahim, Osama Elhardello
Background: Anemia during pregnancy is a public health problem especially in developing countries and it is associated with maternal and perinatal adverse outcomes. There is no meta-analysis on anemia during pregnancy in Sudan. The current systemic review and meta-analysis was conducted to assess the prevalence, types and determinant of anemia during pregnancy in Sudan. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed...
2018: BMC Hematology
Enoch Aninagyei, Emmanuel Tetteh Doku, Patrick Adu, Alexander Egyir-Yawson, Desmond Omane Acheampong
Background: In sub-Saharan Africa where sickle cell trait (SCT) and malaria is prevalent, significant proportions of blood donors may be affected by one or more of these abnormalities. The haemato-biochemical properties of SCT and asymptomatic malaria in donor blood have not been evaluated. This study evaluated the haemato-biochemical impact of SCT and asymptomatic malaria infections in citrate-phosphate-dextrose-adenine (CPDA-1) stored donor blood units. Methods: Fifty-milliliters of sterile CPDA-1 anti-coagulated blood were drained into the sample pouch attached to the main blood bag...
2018: BMC Hematology
Tadele Mulaw, Amare Tariku, Adino Tesfahun Tsegaye, Zegeye Abebe
Background: An individual with visceral Leishmaniasis (VL) commonly present with anemia and one of the VL treatment center in northwest Ethiopia has been recommended iron-folic acid supplementation to these patients. But there is no documented evidence whether iron-folic acid supplementation improves the hematological profile of patients. Therefore, the study aimed to assess change in hemoglobin (Hb) and its determinant factors among VL patients with and without iron-folic acid supplementation in northwest Ethiopia...
2018: BMC Hematology
Sara Aljarad, Ahmad Alhamid, Ahmad Sankari Tarabishi, Ameen Suliman, Ziad Aljarad
Background: Idiopathic (immune) thrombocytopenic purpura (ITP) is an acquired disorder characterized by autoantibodies against platelet membrane antigens. Several studies found an association between Helicobacter Pylori infection and the incidence of ITP. So far, It is still unclear whether H. pylori eradication will increase platelet counts in adult ITP patients. We conduct this study to investigate platelet recovery in ITP patients after H. pylori eradication. Methods: This is a prospective study...
2018: BMC Hematology
Hendry R Sawe, Teri A Reynolds, Juma A Mfinanga, Michael S Runyon, Brittany L Murray, Lee A Wallis, Julie Makani
Background: Sickle cell anaemia (SCA) is prevalent in sub-Saharan Africa, with high risk of complications requiring emergency care. There is limited information about presentation of patients with SCA to hospitals for emergency care. We describe the clinical presentation, resource utilization, and outcomes of SCA patients presenting to the emergency department (ED) at Muhimbili National Hospital (MNH) in Dar es Salaam, Tanzania. Methods: This was a prospective cohort study of consecutive patients with SCA presenting to ED between December 2014 and July 2015...
2018: BMC Hematology
Benjamin Ahenkorah, Kwabena Nsiah, Peter Baffoe, Enoch Odame Anto
Background: Anemia in pregnancy may not only be associated with maternal morbidity and mortality but can also be detrimental to the fetus. A definitive diagnosis of anemia is a pre-requisite to unravelling possible cause(s), to allow appropriate treatment intervention. It is hypothesised that measured hemoglobin (HGB), complemented by biochemical and other hematological parameters would enhance anemia diagnosis. Methods: This was a cross-sectional study among 400 pregnant women comprising 253 anemic and 147 non-anemic pregnant women, attending an antenatal clinic at Bolgatanga Regional Hospital, Ghana...
2018: BMC Hematology
Akueté Yvon Segbena, Aldiouma Guindo, Romain Buono, Irénée Kueviakoe, Dapa A Diallo, Gregory Guernec, Mouhoudine Yerima, Pierre Guindo, Emilie Lauressergues, Aude Mondeilh, Valentina Picot, Valériane Leroy
Background: Sickle cell disease (SCD) accounts for 5% of mortality in African children aged < 5 years. Improving the care management and quality of life of patients with SCD requires a reliable diagnosis in resource-limited settings. We assessed the diagnostic accuracy of the rapid Sickle SCAN® point-of-care (POC) test for SCD used in field conditions in two West-African countries. Methods: We conducted a case-control study in Bamako (Mali) and Lomé (Togo)...
2018: BMC Hematology
Zelalem Teklemariam, Habtamu Mitiku, Fitsum Weldegebreal
Background: The use of unscreened blood exposes the patient to many transfusion transmitted infections including Hepatitis B Virus (HBV), Hepatitis C virus (HCV), Human Immunodeficiency Virus (HIV), and syphilis, among others. Thus, blood transfusion demands for meticulous pre-transfusion testing and screening. Trends of transfusion transmitted infections are important to take appropriate measures on blood bank services. Therefore the aim of this study was to assess seroprevalence and trends of transfusion transmitted infections at Harar blood bank in Harari regional state, Eastern Ethiopia from 2008 to 2015...
2018: BMC Hematology
Olivier Mukuku, Joseph K Sungu, Augustin Mulangu Mutombo, Paul Makan Mawaw, Michel Ntetani Aloni, Stanislas Okitotsho Wembonyama, Oscar Numbi Luboya
Background: Sickle Cell Anemia (SCA) is characterized by high levels of oxidative stress markers and low levels of antioxidant capacity. Antioxidant defence mechanisms against the harmful effects of ROS requires cellular and extracellular enzymes. These enzymes requires micronutrient for complete activity. Information on micronutrients such as manganese, cobalt and copper in SCA population was poorly documented in the literature. Methods: Plasma copper, manganese, cobalt and albumin concentrations determined by atomic absorption spectrophotometry were compared between two groups of children: 76 with SCA (Hb-SS) and 76 without SCA (controls)...
2018: BMC Hematology
Haileleul Micho, Yasin Mohammed, Daniel Hailu, Solomon Genet
Background: Tumor lysis syndrome (TLS) is a life-threatening emergency disorder, caused by an abrupt release of intracellular metabolites after tumor cell death. It is characterized by a series of metabolic manifestations, especially hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia. The aim of this study was to evaluate and characterize the incidence of tumor lysis syndrome among pediatric oncology patients before and after treatment. Methods: Hospital based prospective cohort study was conducted for 6 months on 61 newly diagnosed pediatric oncology patients...
2018: BMC Hematology
Abdulsamad Wafa, Suher ALmedania, Abdulmunim Aljapawe, Thomas Liehr, Soulaiman E Soulaiman, Raja Mouna, Moneeb A K Othman, Walid ALachkar
Background: Chromosomal abnormalities are diagnostic and prognostic key factors in acute myeloid leukemia (AML) patients, as they play a central role for risk stratification algorithms. High hyperdiploidy (HH), a rare cytogenetic abnormality seen commonly in elder male AML patients, is normally categorized under AML with complex karyotype (CK). Accordingly, patients with HH generally are associated with low remission rates and a short overall survival. Case presentation: Here we report a case of 21-year-old female, diagnosed with a de novo AML-M1 according to WHO classification and a CK at diagnosis...
2018: BMC Hematology
Juthatip Chaloemwong, Adisak Tantiworawit, Thanawat Rattanathammethee, Sasinee Hantrakool, Chatree Chai-Adisaksopha, Ekarat Rattarittamrong, Lalita Norasetthada
Background: Dengue infection patients are presented with acute febrile illness. Clinical presentations may mimic other infections. The serology for definite diagnosis is costly and inaccessible in many hospitals. We sought to identify the clinical features and hematologic parameters from a complete blood count (CBC) which distinguish dengue infection from other causes. Methods: This was a retrospective single center study from Chiang Mai University Hospital. All patients who presented with acute fever between September 2013 and July 2015 were included...
2018: BMC Hematology
Andrea Kühnl, David Cunningham, Margaret Hutka, Clare Peckitt, Hamoun Rozati, Federica Morano, Irene Chong, Angela Gillbanks, Andrew Wotherspoon, Michelle Harris, Tracey Murray, Ian Chau
Background: In patients presenting with peripheral lymphadenopathy, it is critical to effectively identify those with underlying cancer who require urgent specialist care. Methods: We analyzed a large dataset of 1000 consecutive patients with unexplained lymphadenopathy referred between 2001 and 2009 to the Royal Marsden Hospital (RMH) rapid access lymph node diagnostic clinic (LNDC). Results: Cancer was diagnosed in 14% of patients. Factors predictive for malignant disease were male sex, age, supraclavicular and multiple site involvement...
2018: BMC Hematology
Jean Uwingabiye, Hafid Zahid, Mohamed El Amrani, Fayçal Labrini, Abdelhak Elkhazraji, Driss El Kabbaj, Mohammed Benyahia, Anass Yahyaoui, Rachid Hadef, Nezha Messaoudi
Background: The acquired inhibitors of coagulation have been observed in very rare cases of monoclonal gammopathies. We report a very rare case of anti-factor XI antibodies in patient with plasma cell leukemia (PCL). Case presentation: This is a 59-year-old male patient without pathological history, admitted to the nephrology department for management of renal insufficiency and anemia syndrome. The history and physical examination revealed stigmata of hemorrhagic syndrome including hemothorax and hemoptysis...
2018: BMC Hematology
S K Nissen, A L Laursen, L H Poulsen, T H Mogensen
Background: Deficiency in coagulation factor VIII encoded by F8 results in the X-linked recessive bleeding disorder haemophilia A (HEMA). Here we describe the identification of a novel variant in the factor VIII gene, F8 , in an adult male patient with severe haemophilia A. Case presentation: The patient was diagnosed in early childhood and subsequently co-infected with Hepatitis C and HIV acquired during early blood transfusion for haemophilia in the 1980ies. The identified F8 deletion, c...
2018: BMC Hematology
Henshaw Uchechi Okoroiwu, Ifeyinwa Maryann Okafor
Background: An insight into the utilization pattern helps in future planning of blood drive. This study was conducted to describe the demographic characteristics of the transfusion recipients and pattern of blood and blood product utilization in Nigeria. Methods: Blood bank registers of University of Calabar Teaching Hospital (UCTH) Calabar were analysed for a 12 month period. Number of blood units requested, number of units issued, Cross-match to transfusion ratio (C/T), age, gender, blood group, blood components received, patients ward and clinical diagnosis were computed...
2018: BMC Hematology
Angesom Gebreweld, Delayehu Bekele, Aster Tsegaye
Background: In pregnancy, hematological changes occur in order to meet the demands of the developing fetus and placenta, with major alterations in blood volume. Abnormal hematological profile affects pregnancy and its outcome. This study aimed to assess hematological profiles of pregnant women at a tertiary care teaching hospital. Method: This cross sectional study was conducted among 284 consecutive pregnant women at St. Paul's Hospital Millennium Medical College...
2018: BMC Hematology
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