Ana Beatriz Proença, Beatriz Alexandre-Santos, Isabele Gomes Giori, Jaime Silva Filho Alex-Marques, Clarice Machado-Santos, Marcus Machado, D'Angelo Carlo Magliano, Antonio Claudio Lucas da Nobrega, Eliete Dalla Corte Frantz
Obesity over-activates the classical arm of the renin-angiotensin system (RAS), impairing skeletal muscle remodeling. We aimed to compare the effect of exercise training and enalapril, an angiotensin-converting enzyme inhibitor, on RAS modulation in the skeletal muscle of obese animals. Thus, we divided C57BL/6 mice into two groups: standard chow (SC) and high-fat (HF) diet for 16 weeks. At the eighth week, the HF-fed animals were divided into four subgroups-sedentary (HF), treated with enalapril (HF-E), exercise training protocol (HF-T), and combined interventions (HF-ET)...
May 2024: Physiological Reports