journal
MENU ▼
Read by QxMD icon Read
search

Redox Biology

journal
https://www.readbyqxmd.com/read/29433022/the-aldehyde-dehydrogenase-alda-contributes-to-the-hypochlorite-defense-and-is-redox-controlled-by-protein-s-bacillithiolation-in-staphylococcus-aureus
#1
Marcel Imber, Vu Van Loi, Sylvia Reznikov, Verena Nadin Fritsch, Agnieszka J Pietrzyk-Brzezinska, Janek Prehn, Chris Hamilton, Markus C Wahl, Agnieszka K Bronowska, Haike Antelmann
Staphylococcus aureus produces bacillithiol (BSH) as major low molecular weight (LMW) thiol which functions in thiol-protection and redox-regulation by protein S-bacillithiolation under hypochlorite stress. The aldehyde dehydrogenase AldA was identified as S-bacillithiolated at its active site Cys279 under NaOCl stress in S. aureus. Here, we have studied the expression, function, redox regulation and structural changes of AldA of S. aureus. Transcription of aldA was previously shown to be regulated by the alternative sigma factor SigmaB...
February 5, 2018: Redox Biology
https://www.readbyqxmd.com/read/29413966/lipophilic-ester-and-amide-derivatives-of-rosmarinic-acid-protect-cells-against-h2o2-induced-dna-damage-and-apoptosis-the-potential-role-of-intracellular-accumulation-and-labile-iron-chelation
#2
Paraskevi S Gerogianni, Maria V Chatziathanasiadou, Dimitrios A Diamantis, Andreas G Tzakos, Dimitrios Galaris
Phenolic acids represent abundant components contained in human diet. However, the negative charge in their carboxylic group limits their capacity to diffuse through biological membranes, thus hindering their access to cell interior. In order to promote the diffusion of rosmarinic acid through biological membranes, we synthesized several lipophilic ester- and amide-derivatives of this compound and evaluated their capacity to prevent H2O2-induced DNA damage and apoptosis in cultured human cells. Esterification of the carboxylic moiety with lipophilic groups strongly enhanced the capacity of rosmarinic acid to protect cells...
February 2, 2018: Redox Biology
https://www.readbyqxmd.com/read/29413963/renal-protective-effect-of-polysulfide-in-cisplatin-induced-nephrotoxicity
#3
Xu Cao, Xiaowei Nie, Siping Xiong, Lei Cao, Zhiyuan Wu, Philip K Moore, Jin-Song Bian
Cisplatin is a major chemotherapeutic drug for solid tumors whereas it may lead to severe nephrotoxicity. Despite decades of efforts, effective therapies remain largely lacking for this disease. In the current research, we investigated the therapeutic effect of hydrogen polysulfide, a novel hydrogen sulfide (H2S) derived signaling molecule, in cisplatin nephrotoxicity and the mechanisms involved. Our results showed that polysulfide donor Na2S4 ameliorated cisplatin-caused renal toxicity in vitro and in vivo through suppressing intracellular reactive oxygen species (ROS) generation and downstream mitogen-activated protein kinases (MAPKs) activation...
February 1, 2018: Redox Biology
https://www.readbyqxmd.com/read/29413965/a-glutaredoxin-in-the-mitochondrial-intermembrane-space-has-stage-specific-functions-in-the-thermo-tolerance-and-proliferation-of-african-trypanosomes
#4
Samantha Ebersoll, Blessing Musunda, Torsten Schmenger, Natalie Dirdjaja, Mariana Bonilla, Bruno Manta, Kathrin Ulrich, Marcelo A Comini, R Luise Krauth-Siegel
Trypanosoma brucei glutaredoxin 2 (Grx2) is a dithiol glutaredoxin that is specifically located in the mitochondrial intermembrane space. Bloodstream form parasites lacking Grx2 or both, Grx2 and the cytosolic Grx1, are viable in vitro and infectious to mice suggesting that neither oxidoreductase is needed for survival or infectivity to mammals. A 37 °C to 39 °C shift changes the cellular redox milieu of bloodstream cells to more oxidizing conditions and induces a significantly stronger growth arrest in wildtype parasites compared to the mutant cells...
January 31, 2018: Redox Biology
https://www.readbyqxmd.com/read/29413962/homocysteine-causes-dysfunction-of-chondrocytes-and-oxidative-stress-through-repression-of-sirt1-ampk-pathway-a-possible-link-between-hyperhomocysteinemia-and-osteoarthritis
#5
Ching-Hou Ma, Yen Chun Chiua, Chin-Hsien Wu, I-Ming Jou, Yuan-Kun Tu, Ching-Hsia Hung, Pei-Ling Hsieh, Kun-Ling Tsai
Emerging evidence has indicated that the perturbed expression of homocysteine (Hcy) may induce mitochondrial dysfunction and disturb bone metabolism. Sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) are two critical sensors that regulate mitochondrial biogenesis and have been recognized as therapeutic targets in osteoarthritis (OA). This study was designed to test whether Hcy caused pro-osteoarthritic changes through modulation of SIRT1 and AMPK. Our results showed that administration of Hcy reduced the SIRT1/AMPK/PGC-1α signaling in chondrocytes, leading to mitochondrial dysfunction as a result of increased oxidative stress and apoptosis...
January 31, 2018: Redox Biology
https://www.readbyqxmd.com/read/29413961/13-reasons-why-the-brain-is-susceptible-to-oxidative-stress
#6
REVIEW
James Nathan Cobley, Maria Luisa Fiorello, Damian Miles Bailey
The human brain consumes 20% of the total basal oxygen (O2) budget to support ATP intensive neuronal activity. Without sufficient O2 to support ATP demands, neuronal activity fails, such that, even transient ischemia is neurodegenerative. While the essentiality of O2 to brain function is clear, how oxidative stress causes neurodegeneration is ambiguous. Ambiguity exists because many of the reasons why the brain is susceptible to oxidative stress remain obscure. Many are erroneously understood as the deleterious result of adventitious O2 derived free radical and non-radical species generation...
January 28, 2018: Redox Biology
https://www.readbyqxmd.com/read/29413959/role-of-gut-microbiota-and-oxidative-stress-in-the-progression-of-non-alcoholic-fatty-liver-disease-to-hepatocarcinoma-current-and-innovative-therapeutic-approaches
#7
REVIEW
Antonella Borrelli, Patrizia Bonelli, Franca Maria Tuccillo, Ira D Goldfine, Joseph L Evans, Franco Maria Buonaguro, Aldo Mancini
Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in industrialized countries. NAFLD progresses through the inflammatory phase of non-alcoholic steatohepatitis (NASH) to fibrosis and cirrhosis, with some cases developing liver failure or hepatocellular carcinoma (HCC). Liver biopsy remains the gold standard approach to a definitive diagnosis of NAFLD and the distinction between simple steatosis and NASH. The pathogenesis of NASH is still not clear. Several theories have been proposed ranging from the "Two Hit Theory" to the "Multiple Hit Theory"...
January 27, 2018: Redox Biology
https://www.readbyqxmd.com/read/29413960/total-sulfane-sulfur-bioavailability-reflects-ethnic-and-gender-disparities-in-cardiovascular-disease
#8
Saurabh Rajpal, Pavan Katikaneni, Matthew Deshotels, Sibile Pardue, John Glawe, Xinggui Shen, Nuri Akkus, Kalgi Modi, Ruchi Bhandari, Paari Dominic, Pratap Reddy, Gopi K Kolluru, Christopher G Kevil
Hydrogen sulfide (H2S) has emerged as an important physiological and pathophysiological signaling molecule in the cardiovascular system influencing vascular tone, cytoprotective responses, redox reactions, vascular adaptation, and mitochondrial respiration. However, bioavailable levels of H2S in its various biochemical metabolite forms during clinical cardiovascular disease remain poorly understood. We performed a case-controlled study to quantify and compare the bioavailability of various biochemical forms of H2S in patients with and without cardiovascular disease (CVD)...
January 25, 2018: Redox Biology
https://www.readbyqxmd.com/read/29413964/in-situ-generation-metabolism-and-immunomodulatory-signaling-actions-of-nitro-conjugated-linoleic-acid-in-a-murine-model-of-inflammation
#9
Luis Villacorta, Lucia Minarrieta, Sonia R Salvatore, Nicholas K Khoo, Oren Rom, Zhen Gao, Rebecca C Berman, Soma Jobbagy, Lihua Li, Steven R Woodcock, Y Eugene Chen, Bruce A Freeman, Ana M Ferreira, Francisco J Schopfer, Dario A Vitturi
Conjugated linoleic acid (CLA) is a prime substrate for intra-gastric nitration giving rise to the formation of nitro-conjugated linoleic acid (NO2-CLA). Herein, NO2-CLA generation is demonstrated within the context of acute inflammatory responses both in vitro and in vivo. Macrophage activation resulted in dose- and time-dependent CLA nitration and also in the production of secondary electrophilic and non-electrophilic derivatives. Both exogenous NO2-CLA as well as that generated in situ, attenuated NF-κB-dependent gene expression, decreased pro-inflammatory cytokine production and up-regulated Nrf2-regulated proteins...
January 12, 2018: Redox Biology
https://www.readbyqxmd.com/read/29353219/blocking-mitochondrial-cyclophilin-d-ameliorates-tsh-impaired-defensive-barrier-of-artery
#10
Xiaojing Liu, Heng Du, Qiang Chai, Qing Jia, Lu Liu, Meng Zhao, Jun Li, Hui Tang, Wenbin Chen, Lifang Zhao, Li Fang, Ling Gao, Jiajun Zhao
AIMS: Endothelial cells (ECs) constitute the defensive barrier of vasculature, which maintains the vascular homeostasis. Mitochondrial oxidative stress (mitoOS) in ECs significantly affects the initiation and progression of vascular diseases. The higher serum thyroid stimulating hormone (TSH) level is being recognized as a nonconventional risk factor responsible for the increased risk of cardiovascular diseases in subclinical hypothyroidism (SCH). However, effects and underlying mechanisms of elevated TSH on ECs are still ambiguous...
January 9, 2018: Redox Biology
https://www.readbyqxmd.com/read/29351884/crucial-role-of-chelatable-iron-in-silver-nanoparticles-induced-dna-damage-and-cytotoxicity
#11
Agnieszka Grzelak, Maria Wojewódzka, Sylwia Meczynska-Wielgosz, Mariusz Zuberek, Dominika Wojciechowska, Marcin Kruszewski
Damage to mitochondria and subsequent ROS leakage is a commonly accepted mechanism of nanoparticle toxicity. However, malfunction of mitochondria results in generation of superoxide anion radical (O2•-), which due to the relatively low chemical reactivity is rather unlikely to cause harmful effects triggered by nanoparticles. We show that treatment of HepG2 cells with silver nanoparticles (AgNPs) resulted in generation of H2O2 instead of O2•-, as measured by ROS specific mitochondrial probes. Moreover, addition of a selective iron chelator diminished AgNPs toxicity...
January 9, 2018: Redox Biology
https://www.readbyqxmd.com/read/29413957/2-chlorohexadecanoic-acid-induces-er-stress-and-mitochondrial-dysfunction-in-brain-microvascular-endothelial-cells
#12
Eva Bernhart, Nora Kogelnik, Jürgen Prasch, Benjamin Gottschalk, Madeleine Goeritzer, Maria Rosa Depaoli, Helga Reicher, Christoph Nusshold, Ioanna Plastira, Astrid Hammer, Günter Fauler, Roland Malli, Wolfgang F Graier, Ernst Malle, Wolfgang Sattler
Peripheral leukocytes induce blood-brain barrier (BBB) dysfunction through the release of cytotoxic mediators. These include hypochlorous acid (HOCl) that is formed via the myeloperoxidase-H2O2-chloride system of activated phagocytes. HOCl targets the endogenous pool of ether phospholipids (plasmalogens) generating chlorinated inflammatory mediators like e.g. 2-chlorohexadecanal and its conversion product 2-chlorohexadecanoic acid (2-ClHA). In the cerebrovasculature these compounds inflict damage to brain microvascular endothelial cells (BMVEC) that form the morphological basis of the BBB...
January 5, 2018: Redox Biology
https://www.readbyqxmd.com/read/29331665/blocking-lpa-dependent-signaling-increases-ovarian-cancer-cell-death-in-response-to-chemotherapy
#13
LeAnn C Rogers, Ryan R Davis, Naveen Said, Thomas Hollis, Larry W Daniel
The paradoxical role of reactive oxygen species in cell death versus cell survival establishes a delicate balance between chemotherapy efficacy and management of detrimental side effects. Normal proliferative signaling requires that cells remain inside a redox range that allows reversible protein oxidation to occur. Shifting the redox environment toward highly reducing or oxidizing states leads to cellular stress and cell death. Reactive oxygen species produced in response to Taxol and cisplatin treatment are necessary for effective cancer cell killing but the same ROS leads to damaging side effects in normal tissues...
January 4, 2018: Redox Biology
https://www.readbyqxmd.com/read/29413958/multifaceted-remodeling-by-vitamin-c-boosts-sensitivity-of-mycobacterium-tuberculosis-subpopulations-to-combination-treatment-by-anti-tubercular-drugs
#14
Kriti Sikri, Priyanka Duggal, Chanchal Kumar, Sakshi Dhingra Batra, Atul Vashist, Ashima Bhaskar, Kritika Tripathi, Tavpritesh Sethi, Amit Singh, Jaya Sivaswami Tyagi
Bacterial dormancy is a major impediment to the eradication of tuberculosis (TB), because currently used drugs primarily target actively replicating bacteria. Therefore, decoding of the critical survival pathways in dormant tubercle bacilli is a research priority to formulate new approaches for killing these bacteria. Employing a network-based gene expression analysis approach, we demonstrate that redox active vitamin C (vit C) triggers a multifaceted and robust adaptation response in Mycobacterium tuberculosis (Mtb) involving ~ 67% of the genome...
January 3, 2018: Redox Biology
https://www.readbyqxmd.com/read/29324352/administration-of-exercise-conditioned-plasma-alters-muscle-catalase-kinetics-in-rat-an-argument-for-in-vivo-like-km-instead-of-in-vitro-like-vmax
#15
Aristidis S Veskoukis, Vassilis Paschalis, Antonios Kyparos, Michalis G Nikolaidis
Maximal velocity (Vmax) is a well established biomarker for the assessment of tissue redox status. There is scarce evidence, though, that it does not probably reflect sufficiently in vivo tissue redox profile. Instead, the Michaelis constant (Km) could more adequately image tissue oxidative stress and, thus, be a more physiologically relevant redox biomarker. Therefore, the aim of the present study was to side-by-side compare Vmax and Km of an antioxidant enzyme after implementing an in vivo set up that induces alterations in tissue redox status...
January 3, 2018: Redox Biology
https://www.readbyqxmd.com/read/29353218/sulforaphane-prevents-angiotensin-ii-induced-cardiomyopathy-by-activation-of-nrf2-via-stimulating-the-akt-gsk-3%C3%A3-fyn-pathway
#16
Ying Xin, Yang Bai, Xin Jiang, Shanshan Zhou, Yuehui Wang, Kupper A Wintergerst, Taixing Cui, Honglei Ji, Yi Tan, Lu Cai
AIMS: Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) by sulforaphane (SFN) protects from, and deletion of the Nrf2 gene exaggerates, diabetic cardiomyopathy. Angiotensin II (Ang II) plays a critical role in the development of diabetic cardiomyopathy. Therefore, whether SFN prevents Ang II-induced cardiomyopathy through activation of Nrf2 was examined using wild-type, global deletion of Nrf2 gene (Nrf2-KO) and cardiomyocyte-specific overexpression of Nrf2 gene (Nrf2-TG) mice...
January 2, 2018: Redox Biology
https://www.readbyqxmd.com/read/29331741/extracellular-acidification-induces-ros-and-mptp-mediated-death-in-hek293-cells
#17
José Teixeira, Farhan Basit, Herman G Swarts, Marleen Forkink, Paulo J Oliveira, Peter H G M Willems, Werner J H Koopman
The extracellular pH (pHe) is a key determinant of the cellular (micro)environment and needs to be maintained within strict boundaries to allow normal cell function. Here we used HEK293 cells to study the effects of pHe acidification (24h), induced by mitochondrial inhibitors (rotenone, antimycin A) and/or extracellular HCl addition. Lowering pHe from 7.2 to 5.8 reduced cell viability by 70% and was paralleled by a decrease in cytosolic pH (pHc), hyperpolarization of the mitochondrial membrane potential (Δψ), increased levels of hydroethidine-oxidizing ROS and stimulation of protein carbonylation...
December 30, 2017: Redox Biology
https://www.readbyqxmd.com/read/29306791/empagliflozin-rescues-diabetic-myocardial-microvascular-injury-via-ampk-mediated-inhibition-of-mitochondrial-fission
#18
Hao Zhou, Shuyi Wang, Pingjun Zhu, Shunying Hu, Yundai Chen, Jun Ren
Impaired cardiac microvascular function contributes to diabetic cardiovascular complications although effective therapy remains elusive. Empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor recently approved for treatment of type 2 diabetes, promotes glycosuria excretion and offers cardioprotective actions beyond its glucose-lowering effects. This study was designed to evaluate the effect of empagliflozin on cardiac microvascular injury in diabetes and the underlying mechanism involved with a focus on mitochondria...
December 30, 2017: Redox Biology
https://www.readbyqxmd.com/read/29331666/age-related-oxidative-changes-in-pancreatic-islets-are-predominantly-located-in-the-vascular-system
#19
Richard Kehm, Jeannette König, Kerstin Nowotny, Tobias Jung, Stephanie Deubel, Sabrina Gohlke, Tim Julius Schulz, Annika Höhn
Aged tissues usually show a decreased regenerative capacity accompanied by a decline in functionality. During aging pancreatic islets also undergo several morphological and metabolic changes. Besides proliferative and regenerative limitations, endocrine cells lose their secretory capacity, contributing to a decline in functional islet mass and a deregulated glucose homeostasis. This is linked to several features of aging, such as induction of cellular senescence or the formation of modified proteins, such as advanced glycation end products (AGEs) - the latter mainly examined in relation to hyperglycemia and in disease models...
December 29, 2017: Redox Biology
https://www.readbyqxmd.com/read/29306790/sulfite-induced-protein-radical-formation-in-lps-aerosol-challenged-mice-implications-for-sulfite-sensitivity-in-human-lung-disease
#20
Ashutosh Kumar, Mathilde Triquigneaux, Jennifer Madenspacher, Kalina Ranguelova, John J Bang, Michael B Fessler, Ronald P Mason
Exposure to (bi)sulfite (HSO3-) and sulfite (SO32-) has been shown to induce a wide range of adverse reactions in sensitive individuals. Studies have shown that peroxidase-catalyzed oxidation of (bi)sulfite leads to formation of several reactive free radicals, such as sulfur trioxide anion (.SO3-), peroxymonosulfate (-O3SOO.), and especially the sulfate (SO4. -) anion radicals. One such peroxidase in neutrophils is myeloperoxidase (MPO), which has been shown to form protein radicals. Although formation of (bi)sulfite-derived protein radicals is documented in isolated neutrophils, its involvement and role in in vivo inflammatory processes, has not been demonstrated...
December 29, 2017: Redox Biology
journal
journal
47650
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"