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Journal of Diabetes Research

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https://www.readbyqxmd.com/read/29785400/previous-exercise-training-reduces-markers-of-renal-oxidative-stress-and-inflammation-in-streptozotocin-induced-diabetic-female-rats
#1
Liliany Souza de Brito Amaral, Cláudia Silva Souza, Rildo Aparecido Volpini, Maria Heloisa Massola Shimizu, Ana Carolina de Bragança, Daniele Canale, Antonio Carlos Seguro, Terezila Machado Coimbra, Amélia Cristina Mendes de Magalhães, Telma de Jesus Soares
The aim of this study is to evaluate the effects of regular moderate exercise training initiated previously or after induction of diabetes mellitus on renal oxidative stress and inflammation in STZ-induced diabetic female rats. For this purpose, Wistar rats were divided into five groups: sedentary control (SC), trained control (TC), sedentary diabetic (SD), trained diabetic (TD), and previously trained diabetic (PTD). Only the PTD group was submitted to treadmill running for 4 weeks previously to DM induction with streptozotocin (40 mg/kg, i...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29785399/timing-of-exercise-affects-glycemic-control-in-type-2-diabetes-patients-treated-with-metformin
#2
Tao Huang, Chunyan Lu, Moritz Schumann, Shenglong Le, Yifan Yang, Haihui Zhuang, Qingwei Lu, Jinsheng Liu, Petri Wiklund, Sulin Cheng
Objective: The purpose of the study was to examine the acute effects of the timing of exercise on the glycemic control during and after exercise in T2D. Methods: This study included 26 T2D patients (14 women and 12 men) who were treated with metformin. All patients were tested on four occasions: metformin administration alone (Metf), high-intensity interval training (HIIT) performed at 30 minutes (EX30), 60 minutes (EX60), and 90 minutes (EX90) postbreakfast, respectively...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29770340/diabetes-related-distress-assessment-among-type-2-diabetes-patients
#3
Majed O Aljuaid, Abdulmajeed M Almutairi, Mohammed A Assiri, Dhifallah M Almalki, Khaled Alswat
Background and Objectives: Diabetes is one of the most common chronic diseases; it is a debilitating and hard to live with. Diabetes-related distress (DRD) refers to the emotional and behavioral changes caused by diabetes. Our study aims to assess the prevalence of DRD among type 2 diabetes (T2D) patients using Diabetes Distress Scale-17 items (DDS-17) and its relation to complications and treatment modalities. Methods: A cross-sectional study of adult T2D patients with follow-up visits at the Diabetes and Endocrinology Center in Taif, Saudi Arabia, between January and July 2017...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29770339/red-blood-cell-distribution-width-is-associated-with-carotid-atherosclerosis-in-people-with-type-2-diabetes
#4
J S Nam, C W Ahn, S Kang, K R Kim, J S Park
Aims: Red cell distribution width (RDW) has been shown to be associated with cardiovascular diseases (CVD). The relationship between RDW and carotid intima-media thickness (C-IMT), a marker of subclinical atherosclerosis, has been inconsistent in subjects with cardiovascular risk factors. In this study, we investigated the relationship between RDW and carotid atherosclerosis in people with type 2 diabetes. Methods: Four hundred sixty-nine people with type 2 diabetes without history of cardiovascular or cerebrovascular diseases were enrolled...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29765988/genetic-variability-of-the-glucose-dependent-insulinotropic-peptide-gene-is-involved-in-the-premature-coronary-artery-disease-in-a-chinese-population-with-type-2-diabetes
#5
Xiaowei Ma, Jia Huang, Difei Lu, Nan Gu, Ran Lu, Jianwei Zhang, Hong Zhang, Jianping Li, Junqing Zhang, Xiaohui Guo
Background: Glucose-dependent insulinotropic polypeptide (GIP) is closely related to diabetes and obesity, both of which are confirmed to increase the risk of coronary artery disease (CAD). Our study aimed to investigate whether the polymorphisms in GIP genes could affect the risk of cardiovascular disease in type 2 diabetic patients in the Chinese Han population. Methods: We selected and genotyped two haplotype-tagging single nucleotide polymorphisms (tag-SNPs) (rs2291725 C>T, rs8078510 G>A) of GIP gene based on CHB data in HapMap Phase II database ( r 2 < 0...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29765987/insulin-secretion-and-risk-for-future-diabetes-in-subjects-with-a-nonpositive-insulinogenic-index
#6
Daisuke Aono, Rie Oka, Mitsuhiro Kometani, Yoshimichi Takeda, Shigehiro Karashima, Kenichi Yoshimura, Yoshiyu Takeda, Takashi Yoneda
Aim: To characterize subjects with a nonpositive insulinogenic index and longitudinally observe changes in their glucose tolerance. Subjects and Methods: A historical cohort study was conducted using data from the medical checkups of public school workers. Indices of insulin secretion and insulin sensitivity derived from oral glucose tolerance test (OGTT) and the incidences of diabetes and impaired glucose tolerance (IGT) were compared among subgroups of subjects with different insulinogenic index (change in insulin/change in glucose over the first 30 min on the OGTT)...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29765986/advanced-glycation-end-products-enhance-murine-monocyte-proliferation-in-bone-marrow-and-prime-them-into-an-inflammatory-phenotype-through-mapk-signaling
#7
Xian Jin, Liang Liu, Yaping Zhang, Yin Xiang, Guizhi Yin, Yi Lu, Ludong Shi, Jian Dong, Chengxing Shen
Objective: Increased monocytes, particularly the inflammatory subset, are associated with accelerated atherosclerosis in diabetes through thus far incompletely defined mechanisms. The present study tested the hypothesis that advanced glycation end products (AGEs) promote bone marrow monocytes to proliferate and drive them into an inflammatory phenotype. Methods and Results: In vivo, AGEs (25 mg/kg i.p. for 7 days) increased proportions of CD115+ monocytes and the inflammatory subset, the CD115+ Ly6Chigh cells, in murine bone marrow (flow cytometry analysis (FCM)), and enhanced gene expression of proinflammatory cytokines (IL-1 β and TNF- α ) but only slightly upregulated mRNA expression of anti-inflammatory cytokine (IL-10) (real-time PCR) in monocytes...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29744370/insulin-like-growth-factor-1-at-diagnosis-and-during-subsequent-years-in-adolescents-with-type-1-diabetes
#8
Simona I Chisalita, J Ludvigsson
Background: Type 1 diabetes (T1D) in adolescents is associated with alterations in the insulin-like factor system probably caused both by a deranged metabolism and insulinopenia in the portal vein. Objective: To study how the circulating IGF-1 is affected at diagnosis and during subsequent years in adolescents with T1D. Methods: Ten girls and ten boys with type 1 diabetes (T1D), aged 13.0 ± 1.4 (mean ± SD) years at diagnosis, took part in the study...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29744369/identification-of-protein-kinase-c-isoforms-involved-in-type-1-diabetic-encephalopathy-in-mice
#9
Jiayin Zheng, Yue Wang, Song Han, Yanlin Luo, Xiuli Sun, Ning Zhu, Li Zhao, Junfa Li
Diabetic encephalopathy is a complication of diabetes mellitus characterized by impaired cognitive functions. Protein kinase C (PKC) isoforms are rarely reported on diabetic encephalopathy, although they have been believed to play crucial roles in other diabetic complications. In this study, streptozotocin- (STZ-) induced diabetic mice were found to exhibit learning and memory deficits in the Morris water maze test. Meanwhile, the expression of cPKC β II, nPKC ε , and cPKC γ did not change in the hippocampus, cortex, and striatum at 2 and 8 weeks after STZ injection...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29744368/identification-of-potential-therapeutic-targets-in-the-liver-of-pioglitazone-treated-type-2-diabetes-sprague-dawley-rats-via-expression-profile-chip-and-itraq-assay
#10
Zhong-Xia Lu, Wen-Jun Xu, Yang-Sheng Wu, Chang-Yu Li, Yi-Tao Chen
The aim of the present study was to identify key antidiabetic nodes in the livers of pioglitazone-treated type 2 diabetes mellitus Sprague-Dawley rats by transcriptomic and proteomic analysis. Rats were randomly divided into the control, the diabetes model, and the pioglitazone-treated groups. After treatment with pioglitazone for 11 weeks, the effects on fasting blood glucose, body weight, and blood biochemistry parameters were evaluated. Microarray and iTRAQ analysis were used to determine the differentially expressed genes/proteins in rat livers...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29744367/age-rage-induced-emp-release-via-the-nox-derived-ros-pathway
#11
Ying-Hua Chen, Zhang-Wei Chen, Hong-Mei Li, Xin-Feng Yan, Bo Feng
Objective: Diabetes is associated with accelerated formation of advanced glycation end products (AGEs) that are extensively found in circulating endothelial microparticles (EMPs). This study aimed to investigate whether AGEs have a direct effect on EMP formation and the possible underlying mechanism. Methods: In vitro, cultured human umbilical vein endothelial cells (HUVECs) were incubated with AGEs (200 and 400  μ g/ml) for 24 hours with or without pretreatment with anti-RAGE antibody, NOX inhibitor, or ROS scavenger...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29744366/astaxanthin-promotes-nrf2-are-signaling-to-alleviate-renal-fibronectin-and-collagen-iv-accumulation-in-diabetic-rats
#12
Xiaoyu Zhu, Yongjun Chen, Qing Chen, Huiyuan Yang, Xi Xie
Astaxanthin (AST), a natural keto-carotenoid classified as a xanthophyll, is well known for its antioxidant properties. AST can ameliorate the pathological characteristics of diabetic nephropathy (DN). However, the underlying mechanisms remain to be explored. This study was aimed at exploring whether AST exerts a protective effect on DN via activating nuclear factor erythroid 2-related factor 2- (Nrf2-) antioxidative response element (ARE) signaling. Streptozotocin-induced diabetic rats were treated with AST for 12 weeks...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29744365/high-salt-intake-ameliorates-hyperglycemia-and-insulin-resistance-in-wbn-kob-lepr-fa-fa-rats-a-new-model-of-type-2-diabetes-mellitus
#13
Yoshiichi Takagi, Taichi Sugimoto, Masaya Kobayashi, Mitsuyuki Shirai, Fumitoshi Asai
High-salt intake is a major risk factor for developing hypertension in type 2 diabetes mellitus, but its effects on glucose homeostasis are controversial. We previously found that high-salt intake induces severe hypertension in WBN/Kob diabetic fatty (WBKDF) rats. In the present study, we examined the effects of a high-salt intake on glucose homeostasis in WBKDF rats. Male WBKDF rats and age-matched Wistar rats at 6 weeks of age were each divided into two groups and fed either a normal-sodium (NS, 0.26%) diet or high-sodium (HS, 8%) diet for 7 weeks...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29736403/temporal-trends-in-gestational-diabetes-prevalence-treatment-and-outcomes-at-aarhus-university-hospital-skejby-between-2004-and-2016
#14
Per Glud Ovesen, Jens Fuglsang, Mette Bisgaard Andersen, Charlotte Wolff, Olav Bjørn Petersen, H David McIntyre
Background: The prevalence of gestational diabetes (GDM) is increasing worldwide. The most important risk of GDM in pregnancy is excessive fetal growth, increasing the risk of complications during delivery as well as long-term complications like obesity and diabetes in both the mother and the offspring. Method: All women with GDM who delivered a singleton between 2004 and 2016 were included. The treatment of GDM patients sought to achieve normal blood glucose levels, primarily by diet and exercise...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29725602/study-on-association-of-pentraxin-3-and-diabetic-nephropathy-in-a-rat-model
#15
Xuehai Chen, Jiao Luo, Minmin Wu, Zhuo Pan, Yue Xie, Hongwei Wang, Bicheng Chen, Hong Zhu
Diabetic nephropathy (DN) is a serious microvascular complication of diabetes. Compared with other therapies for diabetic patients, islet transplantation can effectively prevent and reverse diabetes-induced microvascular disease, such as diabetic retinopathy and nephropathy. PTX3 is the only long pentraxin that can be detected in renal tissue. In this study, we investigated the expression of PTX3 when early DN was reversed after islet transplantation. Methods . Diabetes was induced in rats by injecting streptozotocin (STZ)...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29713651/novel-mechanisms-modulating-palmitate-induced-inflammatory-factors-in-hypertrophied-3t3-l1-adipocytes-by-ampk
#16
Naru Morita, Toshio Hosaka, Atsuko Kitahara, Toshitaka Murashima, Hirohisa Onuma, Yoshikazu Sumitani, Kazuto Takahashi, Toshiaki Tanaka, Takuma Kondo, Hitoshi Ishida
Objective: A growing body of evidence indicates that AMP-activated protein kinase (AMPK) contributes to not only energy metabolic homeostasis but also the inhibition of inflammatory responses. However, the underlying mechanisms remain unclear. To elucidate the role of AMPK, in this study, we observed the effects of AMPK activation on monocyte chemoattractant protein-1 (MCP-1) release in mature 3T3-L1 adipocytes. Methods: We observed signal transduction pathways regulating MCP-1, which increased in obese adipocytes, in an in vitro model of hypertrophied 3T3-L1 adipocytes preloaded with palmitate...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29713650/application-of-metabolomics-to-study-effects-of-bariatric-surgery
#17
REVIEW
Paulina Samczuk, Michal Ciborowski, Adam Kretowski
Bariatric surgery was born in the 1950s at the University of Minnesota. From this time, it continues to evolve and, by the same token, gives new or better possibilities to treat not only obesity but also associated comorbidities. Metabolomics is also a relatively young science discipline, and similarly, it shows great potential for the comprehensive study of the dynamic alterations of the metabolome. It has been widely used in medicine, biology studies, biomarker discovery, and prognostic evaluations. Currently, several dozen metabolomics studies were performed to study the effects of bariatric surgery...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29713649/treatment-discontinuation-and-clinical-events-in-type-2-diabetes-patients-treated-with-dipeptidyl-peptidase-4-inhibitors-or-nph-insulin-as-third-line-therapy
#18
Cristiano S Moura, Zale B Rosenberg, Michal Abrahamowicz, Sasha Bernatsky, Hassan Behlouli, Louise Pilote
Objective: To compare dipeptidyl peptidase-4 (DPP-4) inhibitors with neutral protamine Hagedorn (NPH) insulin, in terms of effectiveness and safety for the management of patients with type 2 diabetes mellitus (DM2) not controlled on metformin and sulfonylureas. Methods: A retrospective cohort study of individuals with DM2 newly dispensed with either DPP-4 inhibitors or NPH as third-line therapy, after metformin and sulfonylurea. Treatment discontinuation, macrovascular outcomes, and hypoglycemia were compared using multivariable Cox regression models, adjusted for sex, age, year of cohort entry, place of residence, hypertension, past history of hypoglycemia, diabetic ketoacidosis, comorbidities, and number of visits to emergency departments, outpatient physician, and hospitalizations...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29713648/complications-of-diabetes-2017
#19
EDITORIAL
Konstantinos Papatheodorou, Maciej Banach, Eleni Bekiari, Manfredi Rizzo, Michael Edmonds
No abstract text is available yet for this article.
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29707587/the-relationship-between-social-capital-and-quality-of-life-among-patients-referring-to-diabetes-centers-in-isfahan-iran
#20
Mahmoud Keyvanara, Maryam Afshari, Elham Dezfoulian
Background: Studies have shown that the relationship between social capital (SC) and quality of life (QOL) has an important role in care, prevention, and treatment of some patients. The present study was conducted with the aim to determine the relationship between social capital and QOL of patients with type 2 diabetes. Materials and Methods: This descriptive, correlational study was conducted on 215 individuals selected through quota sampling. To assess social capital, the Social Capital Questionnaire was used, and to evaluate the QOL of patients with type 2 diabetes, the Diabetes Quality of Life (DQOL) Brief Clinical Inventory was used...
2018: Journal of Diabetes Research
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