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Journal of Diabetes Research

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https://www.readbyqxmd.com/read/27896278/lack-of-association-between-slc30a8-variants-and-type-2-diabetes-in-mexican-american-families
#1
Hemant Kulkarni, Manju Mamtani, Juan Manuel Peralta, Vincent Diego, Thomas D Dyer, Harald Goring, Laura Almasy, Michael C Mahaney, Sarah Williams-Blangero, Ravindranath Duggirala, Joanne E Curran, John Blangero
SLC30A8 encodes zinc transporter 8 which is involved in packaging and release of insulin. Evidence for the association of SLC30A8 variants with type 2 diabetes (T2D) is inconclusive. We interrogated single nucleotide polymorphisms (SNPs) around SLC30A8 for association with T2D in high-risk, pedigreed individuals from extended Mexican American families. This study of 118 SNPs within 50 kb of the SLC30A8 locus tested the association with eight T2D-related traits at four levels: (i) each SNP using measured genotype approach (MGA); (ii) interaction of SNPs with age and sex; (iii) combinations of SNPs using Bayesian Quantitative Trait Nucleotide (BQTN) analyses; and (iv) entire gene locus using the gene burden test...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27891524/the-design-usability-and-feasibility-of-a-family-focused-diabetes-self-care-support-mhealth-intervention-for-diverse-low-income-adults-with-type-2-diabetes
#2
Lindsay Satterwhite Mayberry, Cynthia A Berg, Kryseana J Harper, Chandra Y Osborn
Family members' helpful and harmful actions affect adherence to self-care and glycemic control among adults with type 2 diabetes (T2D) and low socioeconomic status. Few family interventions for adults with T2D address harmful actions or use text messages to reach family members. Through user-centered design and iterative usability/feasibility testing, we developed a mHealth intervention for disadvantaged adults with T2D called FAMS. FAMS delivers phone coaching to set self-care goals and improve patient participant's (PP) ability to identify and address family actions that support/impede self-care...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27882333/mhealth-and-ehealth-for-obesity-and-types-2-and-1-diabetes
#3
EDITORIAL
Gianluca Castelnuovo, Giancarlo Mauri, Kayo Waki
No abstract text is available yet for this article.
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27882332/c-peptide-levels-predict-the-effectiveness-of-dipeptidyl-peptidase-4-inhibitor-therapy
#4
Sevin Demir, Sule Temizkan, Mehmet Sargin
Background. Our aim was to define the conditions that affect therapeutic success when dipeptidyl peptidase-4 (DPP-4) inhibitor is added to metformin monotherapy. Materials and Methods. We reviewed the medical records of 56 patients who had received DPP-4 inhibitor as an add-on to metformin monotherapy and evaluated their response in the first year of therapy. Fasting blood glucose (FBG), HbA1c, C-peptide, and weight of the patients were recorded at 3-month intervals during the first year of treatment. Results...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27882331/ectopic-fat-deposition-on-insulin-sensitivity-correlation-of-hepatocellular-lipid-content-and-m-value
#5
Beverly S Hong, Ying Li, Shuiqing Lai, Juan Liu, Hongyu Guan, Weijian Ke, Xiaoying He, Yanbing Li
Purpose. This study aimed to explore the relationship among insulin sensitivity and ectopic fat depots in participants with different glucose status. Methods. Fifty-nine men and women were enrolled in this study: 29 with normal glucose tolerance (NGT), 17 with impaired glucose tolerance (IGT), and 13 with type 2 diabetes mellitus (T2DM). All participants underwent a hyperinsulinemic-euglycemic clamp to assess the insulin sensitivity index (M value) and magnetic resonance imaging to measure the hepatocellular lipid content (HCL), skeletal muscle fat content including intramyocellular lipid (IMCL) and extramyocellular lipid (EMCL) of tibialis anterior (ta), and soleus muscle (sol)...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27882330/aldh2-inhibition-potentiates-high-glucose-stress-induced-injury-in-cultured-cardiomyocytes
#6
Guodong Pan, Mandar Deshpande, Rajarajan A Thandavarayan, Suresh Selvaraj Palaniyandi
Aldehyde dehydrogenase (ALDH) gene superfamily consists of 19 isozymes. They are present in various organs and involved in metabolizing aldehydes that are biologically generated. For instance, ALDH2, a cardiac mitochondrial ALDH isozyme, is known to detoxify 4-hydroxy-2-nonenal, a reactive aldehyde produced upon lipid peroxidation in diabetic conditions. We hypothesized that inhibition of ALDH leads to the accumulation of unmetabolized 4HNE and consequently exacerbates injury in cells subjected to high glucose stress...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27872862/oxygenation-of-the-intraportally-transplanted-pancreatic-islet
#7
Thomas M Suszynski, Efstathios S Avgoustiniatos, Klearchos K Papas
Intraportal islet transplantation (IT) is not widely utilized as a treatment for type 1 diabetes. Oxygenation of the intraportally transplanted islet has not been studied extensively. We present a diffusion-reaction model that predicts the presence of an anoxic core and a larger partly functional core within intraportally transplanted islets. Four variables were studied: islet diameter, islet fractional viability, external oxygen partial pressure (P) (in surrounding portal blood), and presence or absence of a thrombus on the islet surface...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27872861/danish-nationwide-data-reveal-a-link-between-diabetes-mellitus-diabetic-retinopathy-and-glaucoma
#8
Anna Horwitz, Beáta Éva Petrovski, Christian Torp-Pedersen, Miriam Kolko
Aims. To determine the association between treatment against diabetes mellitus (DM) and treatment with antiglaucomatous drugs in the entire Danish population and to investigate the comorbidity between DM and its complications with antiglaucomatous treatment. Methods. Retrospective nationwide cohort study with data over a 16-year follow-up period. The National Danish Registry of Medicinal Products Statistics was used to identify all claimed prescriptions for antiglaucomatous medication and DM drugs. ICD-10 classifications were furthermore used to identify comorbidities between antiglaucomatous medication and the DM complications, diabetic retinopathy (DR), and nephropathy...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27868071/mean-daily-dosage-of-aspirin-and-the-risk-of-incident-alzheimer-s-dementia-in-patients-with-type-2-diabetes-mellitus-a-nationwide-retrospective-cohort-study-in-taiwan
#9
Cheng-Wei Chang, Jorng-Tzong Horng, Chi-Chang Hsu, Jui-Ming Chen
Background. Type 2 diabetes mellitus patients are known to have higher risk of developing dementia while aspirin use has been shown to prevent incident dementia. This study was conducted to evaluate the potential benefits of aspirin use on dementia in patients with type 2 diabetes mellitus and identify the appropriate dosage of aspirin that provides the most benefit. Method. A Taiwan nationwide, population-based retrospective 8-year study was employed to analyze the association between the use of aspirin and incidence of dementia including Alzheimer's disease and non-Alzheimer's dementia using multivariate Cox-proportional hazards regression model and adjusting for several potential confounders...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27868070/adaptation-and-feasibility-study-of-a-digital-health-program-to-prevent-diabetes-among-low-income-patients-results-from-a-partnership-between-a-digital-health-company-and-an-academic-research-team
#10
Valy Fontil, Kelly McDermott, Lina Tieu, Christina Rios, Eliza Gibson, Cynthia Castro Sweet, Mike Payne, Courtney R Lyles
Background. The feasibility of digital health programs to prevent and manage diabetes in low-income patients has not been adequately explored. Methods. Researchers collaborated with a digital health company to adapt a diabetes prevention program for low-income prediabetes patients at a large safety net clinic. We conducted focus groups to assess patient perspectives, revised lessons for improved readability and cultural relevance to low-income and Hispanic patients, conducted a feasibility study of the adapted program in English and Spanish speaking cohorts, and implemented real-time adaptations to the program for commercial use and for a larger trial of in multiple safety net clinics...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27847829/prevalence-of-oral-mucosal-disorders-in-diabetes-mellitus-patients-compared-with-a-control-group
#11
REVIEW
José González-Serrano, Julia Serrano, Rosa María López-Pintor, Víctor Manuel Paredes, Elisabeth Casañas, Gonzalo Hernández
Chronic hyperglycemia is associated with impaired wound healing and higher susceptibility to infections. It is unclear whether patients with diabetes mellitus (DM) present more oral mucosal disorders compared to control groups. The objectives were to compare (a) the prevalence rates of oral mucosal disorders in the DM and non-DM population and (b) the prevalence rates of specific disorders in the DM and non-DM population. Full-text articles were included if they met the following inclusion criteria: (a) they must be original articles from scientific journals, (b) they must be only cross-sectional studies in English, (c) the prevalence of oral mucosal disorders in DM patients must be evaluated, (d) results must be compared with a healthy control group, and (e) oral mucosal disorders must be specified in DM and non-DM group...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27847828/a-computational-model-of-peripheral-photocoagulation-for-the-prevention-of-progressive-diabetic-capillary-occlusion
#12
Thomas J Gast, Xiao Fu, John Scott Gens, James A Glazier
We developed a computational model of the propagation of retinal ischemia in diabetic retinopathy and analyzed the consequences of various patterns and sizes of burns in peripheral retinal photocoagulation. The model addresses retinal ischemia as a phenomenon of adverse local feedback in which once a capillary is occluded there is an elevated probability of occlusion of adjacent capillaries resulting in enlarging areas of retinal ischemia as is commonly seen clinically. Retinal burns of different sizes and patterns, treated as local oxygen sources, are predicted to have different effects on the propagation of retinal ischemia...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27843955/cannabis-use-as-risk-or-protection-for-type-2-diabetes-a-longitudinal-study-of-18%C3%A2-000-swedish-men-and-women
#13
A K Danielsson, A Lundin, A Yaregal, C G Östenson, P Allebeck, E E Agardh
Aims. Whether or not cannabis use may increase or decrease the risk of type 2 diabetes is not clear. We analyzed the association between cannabis and subsequent type 2 diabetes and if a potential positive or reverse association persisted after controlling for potential confounders. Methods. In this population-based cohort study, 17,967 Swedish men and women (aged 18-84 years), who answered an extensive questionnaire in 2002 (including questions on cannabis use), were followed up for new cases of type 2 diabetes (n = 608) by questionnaire (in 2010) and in health registers during 2003-2011...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27843954/continuous-quadrupole-magnetic-separation-of-islets-during-digestion-improves-purified-porcine-islet-viability
#14
Bradley P Weegman, Venkata Sunil Kumar Sajja, Thomas M Suszynski, Michael D Rizzari, William E Scott Iii, Jennifer P Kitzmann, Kate R Mueller, Thomas R Hanley, David J Kennedy, Paul W Todd, Appakalai N Balamurugan, Bernhard J Hering, Klearchos K Papas
Islet transplantation (ITx) is an emerging and promising therapy for patients with uncontrolled type 1 diabetes. The islet isolation and purification processes require exposure to extended cold ischemia, warm-enzymatic digestion, mechanical agitation, and use of damaging chemicals for density gradient separation (DG), all of which reduce viable islet yield. In this paper, we describe initial proof-of-concept studies exploring quadrupole magnetic separation (QMS) of islets as an alternative to DG to reduce exposure to these harsh conditions...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27843953/considerations-for-defining-cytokine-dose-duration-and-milieu-that-are-appropriate-for-modeling-chronic-low-grade-inflammation-in-type-2-diabetes
#15
REVIEW
Craig S Nunemaker
Proinflammatory cytokines have been implicated in the pathophysiology of both type 1 diabetes (T1D) and type 2 diabetes (T2D). T1D is an autoimmune disease involving the adaptive immune system responding to pancreatic beta-cells as antigen-presenting cells. This attracts immune cells that surround pancreatic islets (insulitis) and secrete cytokines, such as IL-1beta, IFN-gamma, and TNF-alpha, in close proximity to pancreatic beta-cells. In contrast, there is little evidence for such a focused autoimmune response in T2D...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27843952/swimming-exercise-alleviated-insulin-resistance-by-regulating-tripartite-motif-family-protein-72-expression-and-akt-signal-pathway-in-sprague-dawley-rats-fed-with-high-fat-diet
#16
Jie Qi, Bo Yang, Cailing Ren, Jian Fu, Jun Zhang
We aimed to investigate whether swimming exercise could improve insulin resistance (IR) by regulating tripartite motif family protein 72 (TRIM72) expression and AKT signal pathway in rats fed with high-fat diet. Five-week-old rats were classified into 3 groups: standard diet as control (CON), high-fat diet (HFD), and HFD plus swimming exercise (Ex-HFD). After 8 weeks, glucose infusion rate (GIR), markers of oxidative stress, mRNA and protein expression of TRIM72, protein of IRS, p-AKT(Ser473), and AKT were determined in quadriceps muscles...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27840834/lay-health-trainers-supporting-self-management-amongst-those-with-low-heath-literacy-and-diabetes-lessons-from-a-mixed-methods-pilot-feasibility-study
#17
Bernadette Bartlam, Trishna Rathod, Gillian Rowlands, Joanne Protheroe
This article reports a mixed methods process evaluation of a pilot feasibility randomised controlled trial comparing a Lay Health Trainer (LHT) intervention and usual care for those with poorly controlled Type 2 Diabetes Melitus (T2DM). Set in a deprived area in the UK, this research explores patient and health care practitioner (HCP) views on whether a structured interview between a patient and a Lay Health Trainer (LHT), for the purpose of developing a tailored self-management plan for patients, is acceptable and likely to change health behaviours...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27840833/atypical-diabetic-foot-ulcer-keratinocyte-protein-signaling-correlates-with-impaired-wound-healing
#18
Glenn D Hoke, Corrine Ramos, Nicholas N Hoke, Mary C Crossland, Lisa G Shawler, Joseph V Boykin
Diabetes mellitus is associated with chronic diabetic foot ulcers (DFUs) and wound infections often resulting in lower extremity amputations. The protein signaling architecture of the mechanisms responsible for impaired DFU healing has not been characterized. In this preliminary clinical study, the intracellular levels of proteins involved in signal transduction networks relevant to wound healing were non-biasedly measured using reverse-phase protein arrays (RPPA) in keratinocytes isolated from DFU wound biopsies...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27833922/the-feasibility-of-health-trainer-improved-patient-self-management-in-patients-with-low-health-literacy-and-poorly-controlled-diabetes-a-pilot-randomised-controlled-trial
#19
Joanne Protheroe, Trishna Rathod, Bernadette Bartlam, Gillian Rowlands, Gerry Richardson, David Reeves
Type 2 diabetes mellitus is most prevalent in deprived communities and patients with low health literacy have worse glycaemic control and higher rates of diabetic complications. However, recruitment from this patient population into intervention trials is highly challenging. We conducted a study to explore the feasibility of recruitment and to assess the effect of a lay health trainer intervention, in patients with low health literacy and poorly controlled diabetes from a socioeconomically disadvantaged population, compared with usual care...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27830158/meeting-the-challenge-of-diabetes-in-ageing-and-diverse-populations-a-review-of-the-literature-from-the-uk
#20
REVIEW
Emma Wilkinson, Muhammad Waqar, Alan Sinclair, Gurch Randhawa
The impact of type 2 diabetes on ageing societies is great and populations across the globe are becoming more diverse. Complications of diabetes unequally affect particular groups in the UK older people, and people with a South Asian background are two population groups with increased risk whose numbers will grow in the future. We explored the evidence about diabetes care for older people with South Asian ethnicity to understand the contexts and mechanisms behind interventions to reduce inequalities. We used a realist approach to review the literature, mapped the main areas where relevant evidence exists, and explored the concepts and mechanisms which underpinned interventions...
2016: Journal of Diabetes Research
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