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Journal of Diabetes Research

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https://www.readbyqxmd.com/read/29333459/assessment-of-insulin-injection-practice-among-diabetes-patients-in-a-tertiary-healthcare-centre-in-nepal-a-preliminary-study
#1
Ramesh Sharma Poudel, Shakti Shrestha, Rano Mal Piryani, Bijaya Basyal, Kalpana Kaucha, Shital Adhikari
Introduction: Proper insulin injection practice is essential for better diabetic control. This study aims to assess the insulin injection practice of patients with diabetes. Materials and Methods: A cross-sectional study was conducted at Chitwan Medical College Teaching Hospital, Bharatpur, Nepal, from February 2017 to May 2017. Patients injecting insulin through insulin pens (n = 43) for a minimum of 4 weeks were consecutively recruited. Patients' baseline characteristics, current insulin injection technique, insulin transportation practice, complications of insulin injection, disposal practice of used needle, and acceptability of insulin were recorded...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29318159/randomized-control-trial-for-reduction-of-body-weight-body-fat-patterning-and-cardiometabolic-risk-factors-in-overweight-worksite-employees-in-delhi-india
#2
Usha Shrivastava, Mahrukh Fatma, Smriti Mohan, Padam Singh, Anoop Misra
Background: We studied the impact of the multicomponent interventions on body weight and cardiometabolic risk factors in overweight individuals working in corporate worksites. Methods: Overweight (BMI ≥ 23 kg/m2) subjects were recruited from four randomised worksites [two active intervention (n, recruited, 180, completed 156) and two control (n, recruited 130, completed 111)]. Intensive intervention was given at intervention worksite. Results: High prevalence (%) of obesity (90...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29318158/excessive-autophagy-activation-and-increased-apoptosis-are-associated-with-palmitic-acid-induced-cardiomyocyte-insulin-resistance
#3
Shanxin Li, Hui Li, Di Yang, Xiuyan Yu, David M Irwin, Gang Niu, Huanran Tan
Diabetic cardiomyopathy (DCM) remains the major cause of death associated with diabetes. Researchers have demonstrated the importance of impaired cardiac insulin signaling in this process. Insulin resistance (IR) is an important predictor of DCM. Previous studies examining the dynamic changes in autophagy during IR have yielded inconsistent results. This study aimed to investigate the dynamic changes in autophagy and apoptosis in the rat H9c2 cardiomyocyte IR model. H9c2 cells were treated with 500 μM palmitic acid (PA) for 24 hours, resulting in the induction of IR...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29318157/effect-of-optimization-of-glycaemic-control-on-mannan-binding-lectin-in-type-1-diabetes
#4
Gry Høst Dørflinger, Charlotte Brink Holt, Steffen Thiel, Jakob Appel Østergaard, Troels Krarup Hansen
Objective: Mannan-binding lectin (MBL) concentration in plasma is increased in subjects with type 1 diabetes and associated with increased mortality and risk of diabetic nephropathy. Recent findings show that pancreas transplantation reduces MBL concentration. Whether the increased MBL concentration is reversed by improved glycaemic control remains unknown. We investigated the effects of improved glycaemic control on MBL concentration in patients with type 1 diabetes. Methods: We measured MBL, fructosamine, and HbA1cat baseline and after 6 weeks in 52 type 1 diabetic patients following the change from conventional insulin therapy to insulin pump therapy...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29279853/insulin-resistance-type-1-and-type-2-diabetes-and-related-complications-2017
#5
EDITORIAL
Joseph Fomusi Ndisang, Alfredo Vannacci, Sharad Rastogi
No abstract text is available yet for this article.
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29259994/perceptions-of-dietary-habits-and-risk-for-type-2-diabetes-among-congolese-immigrants
#6
Daudet Ilunga Tshiswaka, Kelechi D Ibe-Lamberts, Dyna Miandabu Mulunda, Juliet Iwelunmor
Objective: To explore the perceptions of dietary habits and type 2 diabetes risk among Congolese immigrants living in the US. Methods: Data were collected from 20 in-depth interviews and photo-elicitation techniques conducted with Congolese immigrants. The PEN-3 cultural model was used as a guide to analyze the data collected. Results: Participants identified positive, existential, and negative perceptions, enablers, and nurturers associated with dietary habits and type 2 diabetes risk...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29250556/new-insights-into-diabetic-kidney-disease-the-potential-pathogenesis-and-therapeutic-targets
#7
EDITORIAL
Wei Jing Liu, Jochen Reiser, Tae Sun Park, Zhangsuo Liu, Shuta Ishibe
No abstract text is available yet for this article.
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29250555/a-comparison-of-screening-tools-for-the-early-detection-of-peripheral-neuropathy-in-adults-with-and-without-type-2-diabetes
#8
Jennifer J Brown, Shana L Pribesh, Kimberly G Baskette, Aaron I Vinik, Sheri R Colberg
Objective: Examine the effectiveness of the 128 Hz tuning fork, two monofilaments, and Norfolk Quality of Life Diabetic Neuropathy (QOL-DN) questionnaire as tools for the early detection of diabetic peripheral neuropathy (DPN) in overweight, obese, and inactive (OOI) adults or those who have prediabetes (PD) or type 2 diabetes (T2D). Research Design and Methods: Thirty-four adults (mean age 58.4 years ± 12.1) were divided by glycemia (10 OOI normoglycemic, 13 PD, and 11 T2D)...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29238730/interaction-of-pubertal-development-and-metabolic-control-in-adolescents-with-type-1-diabetes-mellitus
#9
M Plamper, B Gohlke, J Woelfle, K Konrad, T Rohrer, S Hofer, W Bonfig, K Fink, R W Holl
Background: In T1DM, delayed pubertal development and reduced final height are associated with inadequate metabolic control. Objective: To assess whether T1DM affects pubertal growth spurt and whether metabolic control during puberty is gender-related. Methods: Using a large multicentre database, longitudinal data from 1294 patients were analysed. Inclusion criteria: complete records of height and HbA1c from the age of seven to 16 years. Exclusion criteria: other significant chronic diseases and medications, T1DM duration less than three months, and initial BMI < 3rd or >97th percentile...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29238729/the-underlying-mechanisms-of-diabetic-myopathy
#10
EDITORIAL
Erick O Hernández-Ochoa, Paola Llanos, Johanna T Lanner
No abstract text is available yet for this article.
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29238728/retinal-photoreceptors-and-microvascular-changes-in-prediabetes-measured-with-adaptive-optics-rtx1%C3%A2-a-case-control-study
#11
Anna Zaleska-Żmijewska, Paweł Piątkiewicz, Barbara Śmigielska, Anna Sokołowska-Oracz, Zbigniew M Wawrzyniak, Dorota Romaniuk, Jerzy Szaflik, Jacek P Szaflik
Background: Patients with prediabetes are at risk for diabetes, cardiovascular events, and microvascular complications. The rtx1 (Imagine Eyes, France) permits early detection of changes in the retinal photoreceptors and vessels. Objective: Cone parameters and retinal microvasculature were analyzed with the rtx1 in 12 prediabetic patients and 22 healthy subjects. The analysis was based on cone density (DM), interphotoreceptor distance (SM), cone packing regularity, and retinal vessel parameters: wall thickness, lumen diameter (LD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29238727/glycyrrhizic-acid-prevents-diabetic-nephropathy-by-activating-ampk-sirt1-pgc-1%C3%AE-signaling-in-db-db-mice
#12
Shaozhang Hou, Ting Zhang, Yuan Li, Fengying Guo, Xiu Jin
Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD). Glycyrrhizic acid (GA) is an effective inhibitor of reactive oxygen species (ROS) production. We investigated the role of GA in the progression of renal injury in DN. Albumin (Alb)/creatinine (crea) levels were significantly lower, and renal histopathology was attenuated in the diabetic db/db mice that were treated with GA (15 mg/kg via intraperitoneal injection) once per day for eight weeks. These changes were associated with significantly lower levels of α-smooth muscle actin (α-SMA) and transforming growth factor β1 (TGF-β1) expression...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29234684/changes-in-the-diaphragm-lipid-content-after-administration-of-streptozotocin-and-high-fat-diet-regime
#13
Bartlomiej Lukaszuk, Agnieszka Miklosz, Malgorzata Zendzian-Piotrowska, Beata Wojcik, Jan Gorski, Adrian Chabowski
The diaphragm is a dome-shaped skeletal muscle indispensable for breathing. Its activity contributes up to 70% of the total ventilatory function at rest. In comparison to other skeletal muscles, it is distinguished by an oxidative phenotype and uninterrupted cyclic contraction pattern. Surprisingly, the research regarding diaphragm diabetic phenotype particularly in the light of lipid-induced insulin resistance is virtually nonexistent. Male Wistar rats were randomly allocated into 3 groups: control, streptozotocin-induced (STZ) type-1 diabetes, and rodents fed with high-fat diet (HFD)...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29230422/novel-semiquantitative-bone-marrow-oedema-score-and-fracture-score-for-the-magnetic-resonance-imaging-assessment-of-the-active-charcot-foot-in-diabetes
#14
L Meacock, N L Petrova, Ana Donaldson, A Isaac, A Briody, R Ramnarine, M E Edmonds, D A Elias
There are no accepted methods to grade bone marrow oedema (BMO) and fracture on magnetic resonance imaging (MRI) scans in Charcot osteoarthropathy. The aim was to devise semiquantitative BMO and fracture scores on foot and ankle MRI scans in diabetic patients with active osteoarthropathy and to assess the agreement in using these scores. Three radiologists assessed 45 scans (Siemens Avanto 1.5T, dedicated foot and ankle coil) and scored independently twenty-two bones (proximal phalanges, medial and lateral sesamoids, metatarsals, tarsals, distal tibial plafond, and medial and lateral malleoli) for BMO (0-no oedema, 1-oedema < 50% of bone volume, and 2-oedema > 50% of bone volume) and fracture (0-no fracture, 1-fracture, and 2-collapse/fragmentation)...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29230421/association-of-vitamin-d-deficiency-and-degree-of-coronary-artery-disease-in-cardiac-patients-with-type-2-diabetes
#15
Ewelina A Dziedzic, Jakub S Gąsior, Mariusz Pawłowski, Marek Dąbrowski
Several modifiable factors may influence cardiac function in diabetic patients. The aim of the study was to evaluate the influence of vitamin D level on the stage of coronary atherosclerosis in cardiac patients diagnosed with type 2 diabetes. The study was performed in 337 consecutive patients undergoing coronarography. The stage of atherosclerosis was evaluated using Coronary Artery Surgery Study Score. The plasma 25(OH)D concentration was determined by an electrochemiluminescence method. Patients without significant lesions in coronary arteries presented the highest 25(OH)D level, significantly higher than patients with one-, two-, and three-vessel coronary artery disease (CAD) (p < 0...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29230420/glycaemic-control-after-metformin-discontinuation-in-diabetic-patients-with-a-declining-renal-function
#16
Theresa Leyco, Davin Ryanputra, Ray Peh, Alexphil Ponce, Chin Meng Khoo
Metformin is contraindicated in diabetic patients with declining renal function. This study examined the glycaemic control in diabetic patients with chronic kidney disease when metformin was discontinued. This was a retrospective study. We screened 2032 diabetic patients who attended the Diabetes Clinic at a tertiary hospital between 1 September 2014 and 30 September 2015. We analyzed the data on 69 patients whom metformin was discontinued due to declining renal function and had a complete 6-month follow-up...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29226155/views-and-experiences-of-new-zealand-women-with-gestational-diabetes-in-achieving-glycaemic-control-targets-the-views-study
#17
Ruth Martis, Julie Brown, Caroline A Crowther
Introduction: Optimal glycaemic control in women with gestational diabetes mellitus (GDM) reduces maternal and infant morbidity. Method: A survey was administered to women diagnosed with GDM to explore their views and experiences in achieving optimal glycaemic control. Results: Sixty women participated. Enablers included being taught to test capillary blood glucose in group settings where the health professional demonstrated this on themselves first (60, 100%); health professionals listening (41, 68%); being reminded to perform blood glucose testing (33, 55%); and being provided healthy meals by friends and family (28, 47%)...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29214183/direct-and-indirect-effects-of-serum-uric-acid-on-blood-sugar-levels-in-patients-with-prediabetes-a-mediation-analysis
#18
Thunyarat Anothaisintawee, Dumrongrat Lertrattananon, Sangsulee Thamakaison, Sirimon Reutrakul, Boonsong Ongphiphadhanakul, Ammarin Thakkinstian
Purpose: To estimate both direct and indirect effects (through obesity) of serum uric acid (SUA) on blood sugar in prediabetes patients. Methods: Prediabetes patients who came to the outpatient clinic of the Department of Family Medicine, Ramathibodi Hospital, were included in this cross-sectional study. Mediation analysis was applied to determine direct and indirect effects of SUA on glycemic parameters (fasting plasma glucose (FPG) and HbA1c) through waist circumference (WC)...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29214182/thyroid-dysfunction-among-greek-patients-with-type-1-and-type-2-diabetes-mellitus-as-a-disregarded-comorbidity
#19
Maria E Barmpari, Maria Kokkorou, Anastasia Micheli, Irene Alexiou, Elefteria Spanou, Marina Noutsou, Anastasia Thanopoulou
Introduction: The aim of this study was to determine the prevalence of thyroid dysfunction in Greek patients with type 1 (T1DM) and type 2 (T2DM) diabetes mellitus as well as its possible relations to glycaemic control and to diabetic complications. Methods: A total of 1015 patients, consecutively followed in the Outpatient Diabetes Center, were studied. Anthropometric and biochemical measurements, occurrence of diabetes complications, and classical comorbidities were assessed...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29214181/cardiac-autonomic-neuropathy-why-should-cardiologists-care-about-that
#20
REVIEW
Andrzej Bissinger
Background: Cardiac autonomic neuropathy (CAN) is a frequent but underdiagnosed complication of diabetes mellitus. It has a strong influence on various cardiac disorders including myocardial ischemia and infarction, hypertension, orthostatic hypotonia, heart failure, and arrhythmias. CAN can lead to severe morbidity and mortality and increase the risk of sudden cardiac death. Methods: This review article summarizes the latest evidence regarding the epidemiology, pathogenesis, influence on the cardiovascular system, and diagnostic methods for CAN...
2017: Journal of Diabetes Research
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