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Journal of Diabetes Research

Thamudi D Sundarapperuma, Champa J Wijesinghe, Priyadarshika Hettiarachchi, Sudharshani Wasalathanthri
Background: Gestational diabetes mellitus (GDM) is a global concern. GDM mothers have a 7-fold relative risk of developing type 2 diabetes mellitus (T2DM) in their later life. User-friendly and culturally acceptable dietary interventions can minimize this risk. Therefore, this study aims at exploring the perceptions of GDM mothers and health care workers regarding factors that influence postpartum dietary practices aimed at attenuating the trajectory from GDM to DM. Methods: The study was conducted in selected MOH areas in three districts of Sri Lanka...
2018: Journal of Diabetes Research
Golnaz Azami, Kim Lam Soh, Shariff Ghazali Sazlina, Md Said Salmiah, Sanaz Aazami, Mosayeb Mozafari, Hamid Taghinejad
In recent years, great emphasis has been placed on the role of nonpharmacological self-management in the care of patients with diabetes. Studies have reported that nurses, compared to other healthcare professionals, are more likely to promote preventive healthcare seeking behaviors. The aim of this study was to investigate the effectiveness of a nurse-led diabetes self-management education on glycosylated hemoglobin. A two-arm parallel-group randomized controlled trial with the blinded outcome assessors was designed...
2018: Journal of Diabetes Research
Jia Li, Yao-Ming Xue, Bo Zhu, Yong-Hua Pan, Yan Zhang, Chunxia Wang, Yuhao Li
Rosiglitazone is an agonist of peroxisome proliferator-activated receptor- (PPAR-) γ that is principally associated with insulin action. The exact mechanisms underlying its insulin-sensitizing action are still not fully elucidated. It is well known that adiponectin mostly secreted in adipose tissue is an insulin sensitizer. Here, we found that treatment of Otsuka Long-Evans Tokushima Fatty (OLETF) rats with rosiglitazone (3 mg/kg, once daily, by oral gavage for 33 weeks) attenuated the increase in fasting plasma insulin concentrations and the index of the homeostasis model assessment of insulin resistance along with the age growth and glucose concentrations during an oral glucose tolerance test...
2018: Journal of Diabetes Research
Shao-Jie Pang, Qing-Qing Man, Shuang Song, Peng-Kun Song, Zhen Liu, Yu-Qian Li, Shan-Shan Jia, Jing-Zhong Wang, Wen-Hua Zhao, Jian Zhang
Introduction: To study the influence of different glycemic statuses on the relationship of insulin action to age, gender, body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) among Chinese population. Methods: A total of 35,327 participants (17,456 males and 17,871 females) were included in this nationally representative cross-sectional study. Glycemic status was defined according to the 2010 American Diabetes Association criteria. Fasting insulin was measured by the chemiluminescence method...
2018: Journal of Diabetes Research
Murat Karaoglan, Fahriye Eksi
Objective: Viruses trigger and promote islet cell destruction and cause type 1 diabetes mellitus (T1DM). However, the existence of a cause-and-effect relationship is under debate. The aim of this study is to investigate the sero-epidemiological and molecular evidence on enteroviruses and respiratory viruses in patients with newly diagnosed T1DM during the cold season. Design: Forty children newly diagnosed with T1DM and 30 healthy children who presented to the clinic over the course of a year were included in the study...
2018: Journal of Diabetes Research
Chen Liu, Wu QiNan, Lei XiaoTian, Yang MengLiu, Gan XiaGuang, Leng WeiLing, Liang ZiWen, Zhang Ling, Yang GangYi, Chen Bing
Islet β cell apoptosis plays an important role in type 2 diabetes. We previously reported that Par-4-mediated islet β cell apoptosis is induced by high-glucose/fatty acid levels. In the present study, we show that Par-4, which is induced by high-glucose/fatty acid levels, interacts with and inhibits TERT in the cytoplasm and then translocates to the nucleus. Par-4 also inhibited Akt phosphorylation, leading to islet β cell apoptosis. We inhibited Par-4 in islet β cells under high-glucose/fatty acid conditions and knocked out Par-4 in diabetic mice, which led to the up-regulation of TERT and an improvement in the apoptosis rate...
2018: Journal of Diabetes Research
Wan Zhou, Shan-Dong Ye, Chao Chen, Wei Wang
The purposes of this study were to evaluate the expression of retinol-binding protein 4 (RBP4) in diabetic rats with atherosclerosis and to investigate the role of vitamin D intervention. Male Wistar rats were randomly divided into 4 groups, including the control group (NC), the diabetic rats (DM1), the untreated diabetic atherosclerosis rats (DM2), and the vitamin D-treated diabetic atherosclerosis rats (DM3). The levels of serum and adipose RBP4, fasting insulin (FINS), fasting plasma glucose (FPG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), 25-hydroxyvitamin D [25(OH)D], C-reactive protein (CRP), and systolic blood pressure (SBP) were measured...
2018: Journal of Diabetes Research
Xiang Xie, Dan Yan, Haobo Li, Qiqi Zhu, Jun Li, Yong-Ping Fang, Chi Wai Cheung, Michael G Irwin, Zhengyuan Xia, Qingquan Lian
Nonalcoholic fatty liver disease (NAFLD) is a common liver disease which has been previously shown to be associated with type 2 diabetes mellitus (T2DM). Recent research has indicated that type 1 diabetes mellitus (T1DM) is also involved in the development of nonalcoholic fatty liver disease, whereas the underlying mechanisms are largely unknown. Forkhead box O1 (FoxO1) and adiponectin (APN) have been proposed to play an important role in the processes in NAFLD in T1DM. We herein investigated the effects of FoxO1 and APN on the development of NAFLD and the underlying mechanism in streptozotocin-induced T1DM...
2018: Journal of Diabetes Research
Hayfaa Wahabi
Objectives: The objective of this study was to determine the incidence and risk factors of glucose intolerance one year after delivery in women with gestational diabetes (GDM). Methods: All women who had GDM and completed one year since delivery at King Khalid University Hospital were contacted to participate in the study. Based on to the American Diabetes Association criteria and the results of fasting blood glucose (FPG) and HbA1c, participants were classified into three groups: diabetic, impaired glucose tolerance (IGT), and normal...
2018: Journal of Diabetes Research
Mingxia Wu, Hang Pan, Weiling Leng, Xiaotian Lei, Liu Chen, Ziwen Liang
Objective: To investigate the microbial distribution and drug susceptibility among diabetic foot ulcers (DFUs) with different Wagner grades and between acute and chronic DFUs . Methods . We enrolled 428 DFU patients who were hospitalized and treated in the Southwest Hospital. We collected deep ulcer secretion for microbial culture and drug susceptibility tests and analyzed the results. We reexamined 67 patients with poor anti-infection efficacy and analyzed microbial species. Results : The 354 positive samples included 201 cases (56...
2018: Journal of Diabetes Research
Hui Li, Lulu Song, Lijun Shen, Bingqing Liu, Xiaoxuan Zheng, Lina Zhang, Youjie Wang, Zhongqiang Cao, Shunqing Xu
Background: The aim of this study was to examine the association between height and plasma glucose level, as well as risk of GDM among Chinese women. Methods: A total of 6941 pregnant Chinese women were recruited from the Healthy Baby Cohort study in Hubei Province, China, in 2012-2014. Measured height was categorized into four groups according to the quartile distribution (≤158.0 cm, 158.1-161.0 cm, 161.1-164.0 cm, and >164.0 cm). GDM was defined based on the International Association of the Diabetes in Pregnancy Study Group criteria...
2018: Journal of Diabetes Research
Theresa van Gemert, Wolfgang Wölwer, Katharina S Weber, Annika Hoyer, Klaus Strassburger, Nora T Bohnau, Marie A Brüggen, Katharina Ovelgönne, Eva-Maria Gössmann, Volker Burkart, Julia Szendroedi, Michael Roden, Karsten Müssig
Objective: To test whether cognitive function is impaired in early states of diabetes and to identify possible risk factors for cognitive impairment. Methods: A cross-sectional analysis within the German Diabetes Study included patients with type 1 or type 2 diabetes within the first year after diagnosis or five years after study inclusion and metabolically healthy individuals. Participants underwent comprehensive metabolic phenotyping and testing of different domains of cognitive function...
2018: Journal of Diabetes Research
Xiuting Huang, Siqian Gong, Yumin Ma, Xiaoling Cai, Lingli Zhou, Yingying Luo, Meng Li, Wei Liu, Simin Zhang, Xiuying Zhang, Qian Ren, Yu Zhu, Xianghai Zhou, Rui Zhang, Ling Chen, Xueying Gao, Fang Zhang, Yanai Wang, Xueyao Han, Linong Ji
miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. HNF1A variants can cause diabetes and might be involved in the development of primary liver neoplasm. Differences in miR-122 expression among different types of diabetes have not been studied. This study aimed to investigate differences in serum miR-122 levels in Chinese patients with different forms of diabetes, including T2DM, type 1 diabetes (T1DM), HNF1A variant-induced diabetes (HNF1A-DM), glucokinase variant-induced diabetes (GCK-DM), and mitochondrial A3243G mutation-induced diabetes (MDM)...
2018: Journal of Diabetes Research
Qian Wang, Xu Zhang, Li Fang, Qingbo Guan, Ling Gao, Qiu Li
The main aim of this study is to quantitatively describe the status of physical activity and evaluate its levels in a rural population and to investigate the association between the quantifiable physical activity and type 2 diabetes and metabolic syndrome. In total, 2076 participants aged over 40 years were included in a cross-sectional analysis. Physical activity status and the contributions of different types of activity were evaluated. The association between social behaviors and physical activities was analyzed...
2018: Journal of Diabetes Research
Rasmus Bo Jansen, Tomas Møller Christensen, Jens Bülow, Lene Rørdam, Niklas Rye Jørgensen, Ole Lander Svendsen
Objective: Due to the localized nature of Charcot foot, systemically altered levels of inflammation markers can be difficult to measure. The aim of this study was to investigate whether it is possible to detect an arteriovenous (A-V) flux in any locally produced inflammatory biomarkers from an acute Charcot foot by comparing local and systemic measurements. Methods: We included patients with acute diabetic Charcot foot. Blood was sampled from the vena saphena magna on the distal part of the crus bilaterally as well as from the arteria radialis...
2018: Journal of Diabetes Research
Kyo Won Lee, Tae Min Kim, Kyeong Sik Kim, Seunghwan Lee, Junhun Cho, Jae Berm Park, Ghee Young Kwon, Sung Joo Kim
Clinically, acute kidney injury (AKI) episodes in diabetes mellitus (DM) patients are associated with a cumulative risk of developing end-stage renal disease. In this study, we asked whether the severity of AKI induced by renal ischemia-reperfusion injury (IRI) is more prominent in DM than in non-DM control using a cynomolgus monkey ( Macaca fascicularis) model. We also investigated whether human bone marrow-derived mesenchymal stem cells (hBM-MSCs) infused via the renal artery could ameliorate renal IRI in DM monkeys...
2018: Journal of Diabetes Research
Khalid Sheikh, Sara K Bartz, Sarah K Lyons, Daniel J DeSalvo
Aim: The purpose of this cross-sectional study was to determine the rates of diabetes device use (insulin pump and continuous glucose monitor (CGM)) and association with glycemic control in youth with type 1 diabetes in a large, diverse pediatric center. Methods: Demographic and clinical data were obtained from 1992 patients who met the eligibility criteria (age < 26 years, diabetes duration ≥ 1 year, and ≥1 clinic visit in the preceding 12 months)...
2018: Journal of Diabetes Research
Caroline Jane Magri, Dillon Mintoff, Liberato Camilleri, Robert G Xuereb, Joseph Galea, Stephen Fava
Objective: Type 2 diabetes mellitus (T2DM) is known to be associated with increased cardiovascular risk. The aim of this study was therefore to investigate the independent effects of hyperglycaemia, hypoglycaemia, and glucose variability on microvascular and macrovascular disease in T2DM. Methods: Subjects with T2DM of <10 years duration and on stable antiglycaemic treatment underwent carotid intima-media thickness (CIMT), ankle-brachial index (ABI), albumin-creatinine ratio (ACR), and HbA1c measurement, as well as 72-hour continuous glucose monitoring...
2018: Journal of Diabetes Research
Michał Bulc, Katarzyna Palus, Jarosław Całka, Łukasz Zielonka
One of the most frequently reported disorders associated with diabetes is gastrointestinal (GI) disturbance. Although pathogenesis of these complications is multifactorial, the complicity of the enteric nervous system (ENS) in this respect has significant importance. Therefore, this paper analysed changes in substance P- (SP-), calcitonin gene-related peptide- (CGRP-), and leu5-enkephalin- (L-ENK-) like immunoreactivity (LI) in enteric stomach neurons caused by chemically induced diabetes in a porcine model...
2018: Journal of Diabetes Research
Eldad Fisher, Liora Lazar, Shlomit Shalitin, Michal Yackobovitch-Gavan, Liat de Vries, Tal Oron, Ariel Tenenbaum, Moshe Phillip, Yael Lebenthal
Aims: The transition of emerging adults with type 1 diabetes (T1D) from pediatric diabetes clinics to adult clinics between 18 and 21 years of age could result in decreased clinic attendance and thus worsen glycemic control. Our institutional policy offering surveillance till age 30 enabled us to evaluate clinic attendance without the confounding effect of transition. Our aim was to determine the association between glycemic control (HbA1c) and attendance rate. Methods: The medical records of 261 (54% males) young adult T1D patients (median age 22...
2018: Journal of Diabetes Research
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