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Journal of Diabetes Research

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https://www.readbyqxmd.com/read/29138754/the-relation-between-periodontopathogenic-bacterial-levels-and-resistin-in-the-saliva-of-obese-type-2-diabetic-patients
#1
Natheer Al-Rawi, Farah Al-Marzooq
This study aims to investigate the relation between resistin and periodontopathogenic bacterial levels in the saliva of obese adults compared to healthy control and to examine whether salivary resistin can serve as a biomarker of type 2 diabetes in obese patients. A total of 78 saliva samples were collected from patients attending to the University Dental Hospital, Sharjah, UAE. The patients were divided into three equal groups: obese diabetics, obese nondiabetics, and nonobese nondiabetic control. Salivary resistin was measured using ELISA...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29130053/treatment-gaps-found-in-the-management-of-type-2-diabetes-at-a-community-health-centre-in-johannesburg-south-africa
#2
Yacob Pinchevsky, Neil Butkow, Tobias Chirwa, Frederick Raal
Aims: The management of cardiometabolic goals or "ABCs" (HbA1c, blood pressure (BP), and cholesterol) ultimately determines the morbidity and mortality outcomes in patients with type 2 diabetes mellitus (T2DM). We sought to determine if patients with T2DM attending an urbanized public sector community health centre (CHC) were having their ABCs measured, were treated with appropriate cardioprotective agents and finally, were achieving guideline-based targets. Methods and Results: A cross-sectional record review of 519 patients was conducted between May and August 2015...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29130052/the-diabetic-foot
#3
EDITORIAL
I Migdalis, L Czupryniak, N Lalic, R D Leslie, N Papanas, P Valensi
No abstract text is available yet for this article.
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29119118/diagnostic-accuracy-of-monofilament-tests-for-detecting-diabetic-peripheral-neuropathy-a-systematic-review-and-meta-analysis
#4
REVIEW
Fengyi Wang, Jiaqi Zhang, Jiadan Yu, Shaxin Liu, Rengang Zhang, Xichao Ma, Yonghong Yang, Pu Wang
Objective: To systematically evaluate the diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Methods: We searched EMBASE (OvidSP), MEDLINE (OvidSP), the Cochrane Library, and Web of Science to identify diagnostic accuracy trials of monofilament tests for detecting diabetic peripheral neuropathy. We used a hierarchical summary receiver operating characteristics (HSROC) model to conduct the meta-analysis of diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29119117/blocking-age-rage-signaling-improved-functional-disorders-of-macrophages-in-diabetic-wound
#5
Qi Wang, Guanya Zhu, Xiaozan Cao, Jiaoyun Dong, Fei Song, Yiwen Niu
Advanced glycosylation end products (AGEs) accumulate in diabetic wounds. Interactions between AGEs and their receptor (RAGE) leads to dermatologic problems in diabetes. Macrophage, which plays important roles in wound healing, highly expresses RAGE. Therefore, we investigated whether RAGE-expressing macrophages might be responsible for impaired wound healing on diabetes. We used anti-RAGE antibody applied topically on diabetic wounds. After confirming that wound healing was improved in anti-RAGE antibody group compared with normal mice, our results showed that macrophages appeared insufficient in the early stage and fading away slowly in the later proliferative phase compared with the control group, which was ameliorated in anti-RAGE antibody-applied wounds...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29109962/micronutrient-intake-in-a-cohort-of-italian-adults-with-type-1-diabetes-adherence-to-dietary-recommendations
#6
Marisa Giorgini, Marilena Vitale, Lutgarda Bozzetto, Ornella Ciano, Angela Giacco, Anna Rivieccio, Ilaria Calabrese, Gabriele Riccardi, Angela A Rivellese, Giovanni Annuzzi
Micronutrients are of fundamental importance in maintaining health status. However, data on their dietary intake are few particularly in persons with diabetes. The aim of this study was to evaluate in adults with type 1 diabetes (T1DM) attending a tertiary-level diabetes center in Southern Italy the intake of micronutrients (both vitamins and minerals) and the adherence to recommendations. Seven-day food records of 60 T1DM patients were analyzed. Micronutrient intake was evaluated based on the Italian food composition tables and expressed as amount per 1000 kcal of energy intake to adjust for possible underreporting...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29104874/akt-mtor-role-in-human-foetoplacental-vascular-insulin-resistance-in-diseases-of-pregnancy
#7
REVIEW
Roberto Villalobos-Labra, Luis Silva, Mario Subiabre, Joaquín Araos, Rocío Salsoso, Bárbara Fuenzalida, Tamara Sáez, Fernando Toledo, Marcelo González, Claudia Quezada, Fabián Pardo, Delia I Chiarello, Andrea Leiva, Luis Sobrevia
Insulin resistance is characteristic of pregnancies where the mother shows metabolic alterations, such as preeclampsia (PE) and gestational diabetes mellitus (GDM), or abnormal maternal conditions such as pregestational maternal obesity (PGMO). Insulin signalling includes activation of insulin receptor substrates 1 and 2 (IRS1/2) as well as Src homology 2 domain-containing transforming protein 1, leading to activation of 44 and 42 kDa mitogen-activated protein kinases and protein kinase B/Akt (Akt) signalling cascades in the human foetoplacental vasculature...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29098166/renoprotective-effects-of-the-dipeptidyl-peptidase-4-inhibitor-sitagliptin-a-review-in-type-2-diabetes
#8
REVIEW
Cristina Mega, Edite Teixeira-de-Lemos, Rosa Fernandes, Flávio Reis
Diabetic nephropathy (DN) is now the single commonest cause of end-stage renal disease (ESRD) worldwide and one of the main causes of death in diabetic patients. It is also acknowledged as an independent risk factor for cardiovascular disease (CVD). Since sitagliptin was approved, many studies have been carried out revealing its ability to not only improve metabolic control but also ameliorate dysfunction in various diabetes-targeted organs, especially the kidney, due to putative underlying cytoprotective properties, namely, its antiapoptotic, antioxidant, anti-inflammatory, and antifibrotic properties...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29098165/a-trpm4-inhibitor-9-phenanthrol-inhibits-glucose-and-glucagon-like-peptide-1-induced-insulin-secretion-from-rat-islets-of-langerhans
#9
Zuheng Ma, Anneli Björklund, Md Shahidul Islam
Pancreatic β-cells express several ion channels of the transient receptor potential family, which play important roles in mediating the stimulus-secretion coupling. One of these channels, the TRPM4 is a Ca(2+)-activated monovalent cation channel. This channel is inhibited by 9-phenanthrol, which also inhibits the TMEM16a Cl(-) channel, and activates the Ca(2+)-activated K(+) channel, Kca3.1. The net effects of ion-channel modulation by 9-phenantherol on the insulin secretion remain unclear. We tested the effects of 9-phenanthrol on glucose- and GLP-1-induced insulin secretion from isolated rat islets in static incubations...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29090222/changes-in-proteinuria-on-the-risk-of-all-cause-mortality-in-people-with-diabetes-or-prediabetes-a-prospective-cohort-study
#10
Yang Sun, Anxin Wang, Xiaoxue Liu, Zhaoping Su, Junjuan Li, Yanxia Luo, Shuohua Chen, Jianli Wang, Xia Li, Zhan Zhao, Huiping Zhu, Shouling Wu, Xiuhua Guo
BACKGROUND: Proteinuria has been related to all-cause mortality, showing regression or progression. However, few studies have focused on the relationship between proteinuria changes and all-cause mortality. The main purpose of this paper is to examine the associations between proteinuria changes and all-cause mortality in people with diabetes or prediabetes. METHODS: Dipstick proteinuria at baseline and a 2-year follow-up were determined in the participants attending the Kailuan prospective cohort study...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29082264/role-of-the-gastrointestinal-tract-microbiome-in-the-pathophysiology-of-diabetes-mellitus
#11
REVIEW
Muhammad U Sohail, Asmaa Althani, Haseeb Anwar, Roberto Rizzi, Hany E Marei
The incidence of diabetes mellitus is rapidly increasing throughout the world. Although the exact cause of the disease is not fully clear, perhaps, genetics, ethnic origin, obesity, age, and lifestyle are considered as few of many contributory factors for the disease pathogenesis. In recent years, the disease progression is particularly linked with functional and taxonomic alterations in the gastrointestinal tract microbiome. A change in microbial diversity, referred as microbial dysbiosis, alters the gut fermentation profile and intestinal wall integrity and causes metabolic endotoxemia, low-grade inflammation, autoimmunity, and other affiliated metabolic disorders...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29082263/increased-serum-angptl8-concentrations-in-patients-with-prediabetes-and-type-2-diabetes
#12
Yanhua Yin, Xiaoying Ding, Liang Peng, Yanqiang Hou, Yunxia Ling, Mingyu Gu, Yufan Wang, Yongde Peng, Haiyan Sun
The objectives of the study were to investigate serum ANGPTL8 concentrations in different glucose metabolic statuses and to explore the correlations between serum ANGPTL8 levels and various metabolic parameters. Serum ANGPTL8 levels were determined using ELISA in 22 subjects with NGT (normal glucose tolerance), 74 subjects with IGR (impaired glucose regulation), and 33 subjects with T2DM (type 2 diabetes mellitus). Subjects with IFG, IGT, CGI, and T2DM had higher levels of serum ANGPTL8 than subjects with NGT...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29082262/vitamin-d-supplementation-improves-mood-in-women-with-type-2-diabetes
#13
Sue Penckofer, Mary Byrn, William Adams, Mary Ann Emanuele, Patricia Mumby, Joanne Kouba, Diane E Wallis
OBJECTIVE: The aim of this study was to determine the effect of vitamin D supplementation on improving mood (depression and anxiety) and health status (mental and physical) in women with type 2 diabetes mellitus (T2DM). METHODS: Fifty women with T2DM and significant depressive symptomology were enrolled into the "Sunshine Study," where weekly vitamin D supplementation (ergocalciferol, 50,000 IU) was given to all participants for six months. The main outcomes included (1) depression (Center for Epidemiologic Studies Depression, CES-D, and Patient Health Questionnaire, PHQ-9), (2) anxiety (State-Trait Anxiety), and (3) health status (Short Form, SF-12)...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29082261/glucagon-like-peptide-1-a-predictor-of-type-2-diabetes
#14
REVIEW
Matthias Ploug Larsen, Signe Sørensen Torekov
BACKGROUND: The incretin effect is impaired in patients with type 2 diabetes. AIM: To assess the relation between the incretin hormone GLP-1 and the prediabetic subtypes: impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and the combined IFG/IGT to investigate whether a low GLP-1 response may be a predictor of prediabetes in adults. METHOD: 298 articles were found using a broad search phrase on the PubMed database and after the assessment of titles and abstracts 19 articles were included...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29082260/fulminant-type-1-diabetes-in-children-a-multicenter-study-in-china
#15
Yi Gu, Yi Wang, Pin Li, Haiyan Wei, Linqi Chen, Qianqi Liu, Yu Liu, Qiaozhi Yang, Xinran Cheng, Lanjie He, Liya Wei, Zhiying Zhu, Yongxing Chen, Fengyun Wang, Xing Shi, Yuxian Cheng, Yan Wei, Jianing Yu, Chunxiu Gong
BACKGROUND: To investigate the hospital-based incidence of FT1D in Chinese children and compare the clinical feature with classical T1DM. METHODS: A cross-sectional study with sixteen hospitals involved. We obtained 23 FT1D cases as group 1, acute-onset T1DM as group 2, and typical T1DM as group 3. RESULTS: The incidence of FT1D was 1.56% in 16 participating hospitals. The mean age at the onset of group 1 was 2.00 (1.08, 6.51) years old, much younger than that of group 2 (6...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29082259/effects-of-renal-denervation-on-insulin-sensitivity-and-inflammatory-markers-in-nondiabetic-patients-with-treatment-resistant-hypertension
#16
Ulla Kampmann, Ole N Mathiassen, Kent L Christensen, Niels H Buus, Mette Bjerre, Henrik Vase, Niels Møller, Anne Kaltoft, Per L Poulsen
Increased sympathetic activity is important in the pathogenesis of hypertension and insulin resistance. Afferent signaling from the kidneys elevates the central sympathetic drive. We investigated the effect of catheter-based renal sympathetic denervation (RDN) on glucose metabolism, inflammatory markers, and blood pressure in nondiabetic patients with treatment-resistant hypertension. Eight subjects were included in an open-labelled study. Each patient was studied before and 6 months after RDN. Endogenous glucose production was assessed by a 3-(3)H glucose tracer, insulin sensitivity was examined by hyperinsulinemic euglycemic clamp, hormones and inflammatory markers were analyzed, and blood pressure was measured by office blood pressure readings and 24-hour ambulatory blood pressure monitoring...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29082258/the-impact-of-ghrelin-in-metabolic-diseases-an-immune-perspective
#17
REVIEW
Jéssica Aparecida da Silva Pereira, Felipe Corrêa da Silva, Pedro Manoel Mendes de Moraes-Vieira
Obesity and insulin resistance have reached epidemic proportions. Obesogenic conditions are associated with increased risk for the development of other comorbidities and obesity-related diseases. In metabolic disorders, there is chronic low-grade inflammation induced by the activation of immune cells, especially in metabolic relevant organs such as white adipose tissue (WAT). These immune cells are regulated by environmental and systemic cues. Ghrelin is a peptide secreted mainly by X/A-like gastric cells and acts through the growth hormone secretagogue receptor (GHS-R)...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29062840/trajectories-of-postload-plasma-glucose-in-the-development-of-type-2-diabetes-in-japanese-adults
#18
Rie Oka, Kyoko Shibata, Masaru Sakurai, Mitsuhiro Kometani, Masakazu Yamagishi, Kenichi Yoshimura, Takashi Yoneda
We aimed to clarify how the trajectories of 1-hour postload plasma glucose (PG) and 2-hour PG were different in the development of type 2 diabetes. Using data of repeated health checkups in Japanese workers from April 2006 to March 2016, longitudinal changes of fasting, 1-hour, and 2-hour PG on the oral glucose tolerance test were analyzed with a linear mixed effects model. Of the 1464 nondiabetic subjects at baseline, 112 subjects progressed to type 2 diabetes during the observation period (progressors). In progressors, 1-hour PG and 2-hour PG showed gradual increases with slopes of 1...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29062839/antidiabetic-effect-of-brain-derived-neurotrophic-factor-and-its-association-with-inflammation-in-type-2-diabetes-mellitus
#19
REVIEW
Ceren Eyileten, Agnieszka Kaplon-Cieslicka, Dagmara Mirowska-Guzel, Lukasz Malek, Marek Postula
Brain-derived neurotrophic factor (BDNF) is a neurotrophin, which plays an important role in the central nervous system, and systemic or peripheral inflammatory conditions, such as acute coronary syndrome and type 2 diabetes mellitus (T2DM). BDNF is also expressed in several nonneuronal tissues, and platelets are the major source of peripheral BDNF. Here, we reviewed the potential role of BDNF in platelet reactivity in T2DM and its association with selected inflammatory and platelet activation mediators. Besides that, we focused on adipocytokines such as leptin, resistin, and adiponectin which are considered to take part in inflammation and both lipid and glucose metabolism in diabetic patients as previous studies showed the relation between adipocytokines and BDNF...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29057274/effectiveness-of-vildagliptin-in-clinical-practice-pooled-analysis-of-three-korean-observational-studies-the-victory-study
#20
Sunghwan Suh, Sun Ok Song, Jae Hyeon Kim, Hyungjin Cho, Woo Je Lee, Byung-Wan Lee
The present observational study aimed to evaluate the clinical effectiveness of vildagliptin with metformin in Korean patients with type 2 diabetes mellitus (T2DM). Data were pooled from the vildagliptin postmarketing survey (PMS), the vildagliptin/metformin fixed drug combination (DC) PMS, and a retrospective observational study of vildagliptin/metformin (fixed DC or free DC). The effectiveness endpoint was the proportion of patients who achieved a glycemic target (HbA1c) of ≤7.0% at 24 weeks. In total, 4303 patients were included in the analysis; of these, 2087 patients were eligible...
2017: Journal of Diabetes Research
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