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Journal of Diabetes Research

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https://www.readbyqxmd.com/read/28316995/classification-and-differential-diagnosis-of-diabetic-nephropathy
#1
REVIEW
Chenyang Qi, Xing Mao, Zhigang Zhang, Huijuan Wu
Diabetic nephropathy (DN) is a major cause of end-stage renal disease throughout the world in both developed and developing countries. This review briefly introduces the characteristic pathological changes of DN and Tervaert pathological classification, which divides DN into four classifications according to glomerular lesions, along with a separate scoring system for tubular, interstitial, and vascular lesions. Given the heterogeneity of the renal lesions and the complex mechanism underlying diabetic nephropathy, Tervaert classification has both significance and controversies in the guidance of diagnosis and prognosis...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28299342/relationship-between-immunological-abnormalities-in-rat-models-of-diabetes-mellitus-and-the-amplification-circuits-for-diabetes
#2
REVIEW
Yuji Takeda, Tomoko Shimomura, Hironobu Asao, Ichiro Wakabayashi
A better understanding of pathogenic mechanisms is required in order to treat diseases. However, the mechanisms of diabetes mellitus and diabetic complications are extremely complex. Immune reactions are involved in the pathogenesis of diabetes and its complications, while diabetes influences immune reactions. Furthermore, both diabetes and immune reactions are influenced by genetic and environmental factors. To address these issues, animal models are useful tools. So far, various animal models of diabetes have been developed in rats, which have advantages over mice models in terms of the larger volume of tissue samples and the variety of type 2 diabetes models...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28299341/hepatic-cholesterol-25-hydroxylase-overexpression-improves-systemic-insulin-sensitivity-in-mice
#3
Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner
Obesity is a major risk factor for several diseases including diabetes, heart disease, and some forms of cancer and due to its rapidly increasing prevalence it has become one of the biggest problems medicine is facing today. All the more surprising, a substantial percentage of obese patients are metabolically healthy when classified based on insulin resistance and systemic inflammation. Oxysterols are naturally occurring molecules that play important role in various metabolic and inflammatory processes and their levels are elevated in patients suffering from obesity and diabetes...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28293643/neutrophils-infiltrate-the-spinal-cord-parenchyma-of-rats-with-experimental-diabetic-neuropathy
#4
Victoria L Newton, Jonathan D Guck, Mary A Cotter, Norman E Cameron, Natalie J Gardiner
Spinal glial cell activation and cytokine secretion have been implicated in the etiology of neuropathic pain in a number of experimental models, including diabetic neuropathy. In this study, streptozotocin- (STZ-) induced diabetic rats were either untreated or treated with gabapentin (50 mg/kg/day by gavage for 2 weeks, from 6 weeks after STZ). At 8 weeks after STZ, hypersensitivity was confirmed in the untreated diabetic rats as a reduced response threshold to touch, whilst mechanical thresholds in gabapentin-treated diabetic rats were no different from controls...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28286779/adipokines-potential-therapeutic-targets-for-vascular-dysfunction-in-type-ii-diabetes-mellitus-and-obesity
#5
REVIEW
Mostafa Wanees Ahmed El Husseny, Mediana Mamdouh, Sara Shaban, Abdelrahman Ibrahim Abushouk, Marwa Mostafa Mohamed Zaki, Osama M Ahmed, Mohamed M Abdel-Daim
Adipokines are bioactive molecules that regulate several physiological functions such as energy balance, insulin sensitization, appetite regulation, inflammatory response, and vascular homeostasis. They include proinflammatory cytokines such as adipocyte fatty acid binding protein (A-FABP) and anti-inflammatory cytokines such as adiponectin, as well as vasodilator and vasoconstrictor molecules. In obesity and type II diabetes mellitus (DM), insulin resistance causes impairment of the endocrine function of the perivascular adipose tissue, an imbalance in the secretion of vasoconstrictor and vasodilator molecules, and an increased production of reactive oxygen species...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28286778/prognostic-relevance-and-function-of-msx2-in-colorectal-cancer
#6
Jiancheng Liu, Huaying An, Wei Yuan, Qiang Feng, Lianzhen Chen, Jie Ma
Colorectal cancer patients with diabetes had the high risks of total mortality. High expression of MSX2 is related to development of diabetes. There are few reports about the clinical implications and function of MSX2 in colorectal cancer (CRC). The purpose of this study is to investigate the relationship between the expression of MSX2 and clinical relevance and discover the possible mechanism of MSX2 in the development of CRC. Compared with adjacent tissues, the expression of MSX2 was higher in tumor tissues in both mRNA and protein levels (P < 0...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28286777/effect-of-human-myotubes-derived-media-on-glucose-stimulated-insulin-secretion
#7
Maria L Mizgier, Luis R Cataldo, Juan Gutierrez, José L Santos, Mariana Casas, Paola Llanos, Ariel E Contreras-Ferrat, Cedric Moro, Karim Bouzakri, Jose E Galgani
Fasting to postprandial transition requires a tight adjustment of insulin secretion to its demand, so tissue (e.g., skeletal muscle) glucose supply is assured while hypo-/hyperglycemia are prevented. High muscle glucose disposal after meals is pivotal for adapting to increased glycemia and might drive insulin secretion through muscle-released factors (e.g., myokines). We hypothesized that insulin influences myokine secretion and then increases glucose-stimulated insulin secretion (GSIS). In conditioned media from human myotubes incubated with/without insulin (100 nmol/L) for 24 h, myokines were qualitatively and quantitatively characterized using an antibody-based array and ELISA-based technology, respectively...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28280746/electrochemical-skin-conductance-may-be-used-to-screen-for-diabetic-cardiac-autonomic-neuropathy-in-a-chinese-population-with-diabetes
#8
Tianyi He, Chuan Wang, Anju Zuo, Pan Liu, Ruxing Zhao, Wenjuan Li, Li Chen, Xinguo Hou
Aims. This study aimed to assess whether the electrochemical skin conductance (ESC) could be used to screen for diabetic cardiac autonomic neuropathy (DCAN) in a Chinese population with diabetes. Methods. We recruited 75 patients with type 2 diabetes mellitus (T2DM) and 45 controls without diabetes. DCAN was diagnosed by the cardiovascular autonomic reflex tests (CARTs) as gold standard. In all subjects ESCs of hands and feet were also detected by SUDOSCAN™ as a new screening method. The efficacy was assessed by receiver operating characteristic (ROC) curve analysis...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28280745/medication-adherence-mediates-the-association-between-type-d-personality-and-high-hba1c-level-in-chinese-patients-with-type-2-diabetes-mellitus-a-six-month-follow-up-study
#9
Xuemei Li, Min Gao, Shengfa Zhang, Huiwen Xu, Huixuan Zhou, Xiaohua Wang, Zhiyong Qu, Jing Guo, Weijun Zhang, Donghua Tian
Aims. To examine the association between Type D personality and HbA1c level and to explore the mediating role of medication adherence between them in patients with type 2 diabetes mellitus (T2DM). Methods. 330 patients went on to complete a self-report measure of medication adherence and the HbA1c tests. Chi-square test, T test, Ordinary Least Square Regression (OLS), and Recentered Influence Function Regression (RIF) were employed. Results. Patients with Type D personality had significantly higher HbA1c value (P < 0...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28280744/glycemic-excursions-in-type-1-diabetes-in-pregnancy-a-semiparametric-statistical-approach-to-identify-sensitive-time-points-during-gestation
#10
Resmi Gupta, Jane Khoury, Mekibib Altaye, Lawrence Dolan, Rhonda D Szczesniak
Aim. To examine the gestational glycemic profile and identify specific times during pregnancy that variability in glucose levels, measured by change in velocity and acceleration/deceleration of blood glucose fluctuations, is associated with delivery of a large-for-gestational-age (LGA) baby, in women with type 1 diabetes. Methods. Retrospective analysis of capillary blood glucose levels measured multiple times daily throughout gestation in women with type 1 diabetes was performed using semiparametric mixed models...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28271076/metformin-improves-overall-survival-of-colorectal-cancer-patients-with-diabetes-a-meta-analysis
#11
REVIEW
Fanqiang Meng, Li Song, Wenyue Wang
Introduction. Diabetic population has a higher risk of colorectal cancer (CRC) incidence and mortality than nondiabetics. The role of metformin in CRC prognosis is still controversial. The meta-analysis aims to investigate whether metformin improves the survival of diabetic CRC patients. Methods. PubMed, EMBASE, and Cochrane Library were searched till July 1, 2016. Cohort studies were included. All articles were evaluated by Newcastle-Ottawa Scale. Hazard Ratios (HRs) with 95% confidence intervals (CIs) for each study were calculated and pooled HRs with corresponding 95% CIs were generated using the random-effects model...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28271075/continuous-glucose-monitoring-in-newly-diagnosed-type-2-diabetes-patients-reveals-a-potential-risk-of-hypoglycemia-in-older-men
#12
Feng-Fei Li, Bing-Li Liu, Hong-Hong Zhu, Ting Li, Wen-Li Zhang, Xiao-Fei Su, Jin-Dan Wu, Xue-Qin Wang, Ning Xu, Wei-Nan Yu, Qun Yuan, Guan-Cheng Qi, Lei Ye, Kok-Onn Lee, Jian-Hua Ma
Objectives. We performed continuous glucose monitoring (CGM) to define the features of patients with newly diagnosed type 2 diabetes (T2D) before and after Continuous Subcutaneous Insulin Infusion (CSII) therapy. Methods. This was a retrospective analysis. Newly diagnosed T2D patients (106) were admitted from eight centers in China. They were divided into a younger patient group (<60 years) and an older patient group (≥60 years). Each group was further divided into male and female patients. CSII therapy was maintained for 3 weeks after the glycemic target was reached...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28265579/the-next-frontier-in-communication-and-the-eclippse-study-bridging-the-linguistic-divide-in-secure-messaging
#13
REVIEW
Dean Schillinger, Danielle McNamara, Scott Crossley, Courtney Lyles, Howard H Moffet, Urmimala Sarkar, Nicholas Duran, Jill Allen, Jennifer Liu, Danielle Oryn, Neda Ratanawongsa, Andrew J Karter
Health systems are heavily promoting patient portals. However, limited health literacy (HL) can restrict online communication via secure messaging (SM) because patients' literacy skills must be sufficient to convey and comprehend content while clinicians must encourage and elicit communication from patients and match patients' literacy level. This paper describes the Employing Computational Linguistics to Improve Patient-Provider Secure Email (ECLIPPSE) study, an interdisciplinary effort bringing together scientists in communication, computational linguistics, and health services to employ computational linguistic methods to (1) create a novel Linguistic Complexity Profile (LCP) to characterize communications of patients and clinicians and demonstrate its validity and (2) examine whether providers accommodate communication needs of patients with limited HL by tailoring their SM responses...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28261621/investigating-factors-associated-with-depressive-symptoms-of-chronic-kidney-diseases-in-china-with-type-2-diabetes
#14
Xu Wang, Biyu Shen, Xun Zhuang, Xueqin Wang, Weiqun Weng
Aim. To assess the depressive symptoms status of chronic kidney diseases in Nantong, China, with type 2 diabetes and to identify factors associated with depressive symptoms. Methods. In this cross-sectional analytic study, 210 type 2 diabetic patients were recruited from the Second Affiliated Hospital of Nantong University. Depressive symptoms were assessed with the depression subscale of the Hospital Anxiety and Depression Scale (HAD-D). The quality of life was measured with the RAND 36-Item Health Survey (SF-36)...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28255559/urinary-sodium-concentration-is-an-independent-predictor-of-all-cause-and-cardiovascular-mortality-in-a-type-2-diabetes-cohort-population
#15
Pierre-Jean Saulnier, Elise Gand, Stéphanie Ragot, Lise Bankir, Xavier Piguel, Frédéric Fumeron, Vincent Rigalleau, Jean-Michel Halimi, Richard Marechaud, Ronan Roussel, Samy Hadjadj, Surdiagene Study Group
Objective. Sodium intake is associated with cardiovascular outcomes. However, no study has specifically reported an association between cardiovascular mortality and urinary sodium concentration (UNa). We examined the association of UNa with mortality in a cohort of type 2 diabetes (T2D) patients. Methods. Patients were followed for all-cause death and cardiovascular death. Baseline UNa was measured from second morning spot urinary sample. We used Cox proportional hazard models to identify independent predictors of mortality...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28251164/tnf-alpha-in-peripheral-neuropathy-patients-with-impaired-glucose-regulation
#16
Xia Li, Ju Zhu, Na Liu, Jie Liu, Zhecheng Zhang
Impaired glucose regulation (IGR) is the prestate of diabetes; about 1/3 of IGR patients will develop to diabetes finally. In this study, we investigated the serum tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) levels in peripheral neuropathy impaired patients with impaired glucose regulation (IGR). A total of 70 IGR patients received the conventional nerve conduction test, including 30 patients with peripheral neuropathy (PN) and 40 patients without peripheral neuropathy (NPN). The other 40 healthy individuals were recruited as controls...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28251163/role-of-t-lymphocytes-in-type-2-diabetes-and-diabetes-associated-inflammation
#17
REVIEW
Chang Xia, Xiaoquan Rao, Jixin Zhong
Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28246612/urinary-excretion-of-kidney-aquaporins-as-possible-diagnostic-biomarker-of-diabetic-nephropathy
#18
Luigi Rossi, Maria Celeste Nicoletti, Monica Carmosino, Lisa Mastrofrancesco, Antonella Di Franco, Francesca Indrio, Rossella Lella, Luigi Laviola, Francesco Giorgino, Maria Svelto, Loreto Gesualdo, Giuseppe Procino
Diabetic nephropathy (DN) is a microangiopathic complication of diabetes mellitus (DM) affecting one-third of diabetic patients. The large variability in the clinical presentation of renal involvement in patients with DM makes kidney biopsy a prerequisite for a correct diagnosis. However, renal biopsy is an invasive procedure associated with risk of major complications. Numerous studies aimed to identify a noninvasive biomarker of DN but, so far, none of these is considered to be sufficiently specific and sensitive...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28243608/visual-acuity-retinal-sensitivity-and-macular-thickness-changes-in-diabetic-patients-without-diabetic-retinopathy-after-cataract-surgery
#19
Spela Stunf Pukl, Nataša Vidović Valentinčič, Mojca Urbančič, Irena Irman Grčar, Rok Grčar, Vladimir Pfeifer, Mojca Globočnik Petrovič
Aim. Functional and morphological macular study after cataract surgery in a group of diabetics without diabetic retinopathy compared to nondiabetics to evaluate the effect of surgical oxidative stress on diabetic retina. Methods. Prospective, comparative study. Preoperative eye exam, best corrected visual acuity (BCVA) measured by ETDRS letters, and optical coherence tomography (OCT) were followed by standard cataract surgery. The follow-up visits at 1, 3, and 6 months postoperatively included BCVA, OCT, and microperimetry, to analyze changes within and between the groups...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28232950/transcriptional-profile-of-kidney-from-type-2-diabetic-db-db-mice
#20
Haojun Zhang, Tingting Zhao, Zhiguo Li, Meihua Yan, Hailing Zhao, Bin Zhu, Ping Li
Diabetic nephropathy (DN), a common diabetic microvascular complication, is characterized by progressive glomerular sclerosis and tubulointerstitial fibrosis. However, the underlying mechanisms involved in DN remain to be elucidated. We explored changes in the transcriptional profile in spontaneous type 2 diabetic db/db mice by using the cDNA microarray. Compared with control db/m mice, the db/db mice exhibited marked increases in body weight, kidney weight, and urinary albumin excretion. Renal histological analysis revealed mesangial expansion and thickness of the basement membrane in the kidney of the db/db mice...
2017: Journal of Diabetes Research
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