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Journal of Diabetes Research

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https://www.readbyqxmd.com/read/28529958/spatiotemporal-regulators-for-insulin-stimulated-glut4-vesicle-exocytosis
#1
REVIEW
Xiaoxu Zhou, Ping Shentu, Yingke Xu
Insulin increases glucose uptake and storage in muscle and adipose cells, which is accomplished through the mobilization of intracellular GLUT4 storage vesicles (GSVs) to the cell surface upon stimulation. Importantly, the dysfunction of insulin-regulated GLUT4 trafficking is strongly linked with peripheral insulin resistance and type 2 diabetes in human. The insulin signaling pathway, key signaling molecules involved, and precise trafficking itinerary of GSVs are largely identified. Understanding the interaction between insulin signaling molecules and key regulatory proteins that are involved in spatiotemporal regulation of GLUT4 vesicle exocytosis is of great importance to explain the pathogenesis of diabetes and may provide new potential therapeutic targets...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28512642/role-of-nuclear-factor-erythroid-2-related-factor-2-in-diabetic-nephropathy
#2
REVIEW
Wenpeng Cui, Xu Min, Xiaohong Xu, Bing Du, Ping Luo
Diabetic nephropathy (DN) is manifested as increased urinary protein level, decreased glomerular filtration rate, and final renal dysfunction. DN is the leading cause of end-stage renal disease worldwide and causes a huge societal healthcare burden. Since satisfied treatments are still limited, exploring new strategies for the treatment of this disease is urgently needed. Oxidative stress takes part in the initiation and development of DN. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key role in the cellular response to oxidative stress...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28512641/podocyte-autophagy-a-potential-therapeutic-target-to-prevent-the-progression-of-diabetic-nephropathy
#3
REVIEW
Na Liu, Liuqing Xu, Yingfeng Shi, Shougang Zhuang
Diabetic nephropathy (DN), a leading cause of end-stage renal disease (ESRD), becomes a worldwide problem. Ultrastructural changes of the glomerular filtration barrier, especially the pathological changes of podocytes, lead to proteinuria in patients with diabetes. Podocytes are major components of glomerular filtration barrier, lining outside of the glomerular basement membrane (GBM) to maintain the permeability of the GBM. Autophagy is a high conserved cellular process in lysosomes including impaired protein, cell organelles, and other contents in the cytoplasm...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28491872/incidence-and-contributing-factors-of-persistent-hyperglycemia-at-6-12-weeks-postpartum-in-iranian-women-with-gestational-diabetes-results-from-laga-cohort-study
#4
Sedigheh Nouhjah, Hajieh Shahbazian, Nahid Shahbazian, Alireza Jahanshahi, Shayesteh Jahanfar, Bahman Cheraghian
Background. A history of gestational diabetes is an important predictor of many metabolic disturbances later in life. Method. Life after gestational diabetes Ahvaz Study (LAGAs) is an ongoing population-based cohort study. Up to February 2016, 176 women with gestational diabetes underwent a 75 g oral glucose tolerance test (OGTT) at 6-12 weeks postpartum in Ahvaz (southwestern of Iran). Gestational diabetes was diagnosed according to the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria and the American Diabetes Association (ADA) criteria applied for diagnosis of postpartum prediabetes and diabetes...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28491871/the-imbalance-of-b-lymphocyte-subsets-in-subjects-with-different-glucose-tolerance-relationship-with-metabolic-parameter-and-disease-status
#5
Chao Deng, Yufei Xiang, Tingting Tan, Zhihui Ren, Chuqing Cao, Bingwen Liu, Gan Huang, Xiangbing Wang, Zhiguang Zhou
B lymphocytes are involved in inflammation and are related to insulin resistance in obesity and type 2 diabetes (T2D). This study investigated the phenotype and frequency of B-lymphocyte subsets in subjects recently diagnosed with T2D (n = 60), impaired glucose regulation (IGR, n = 73), and normal glucose tolerance (NGT, n = 169) by flow cytometry. T2D subjects had an increased percentage of CD19(+)CD23(+) (B-2) cells and a decreased percentage of CD19(+)CD23(-) (B-1) cells attributing to CD19(+)CD23(-)CD5(-) (B-1b) cells, but not CD19(+)CD23(-)CD5(+) (B-1a) cells, compared to NGT and IGR subjects...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28491870/noninvasive-retinal-markers-in-diabetic-retinopathy-advancing-from-bench-towards-bedside
#6
REVIEW
Søren Leer Blindbæk, Thomas Lee Torp, Kristian Lundberg, Kerstin Soelberg, Anna Stage Vergmann, Christina Døfler Poulsen, Ulrik Frydkjaer-Olsen, Rebecca Broe, Malin Lundberg Rasmussen, Jimmi Wied, Majbrit Lind, Anders Højslet Vestergaard, Tunde Peto, Jakob Grauslund
The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- and macrovascular dysfunction in diabetes. Likewise, the retinal metabolism can be evaluated by retinal oximetry, and higher retinal venular oxygen saturation has been demonstrated in patients with diabetic retinopathy...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28466023/adipose-tissue-specialized-immunologic-features-might-be-the-potential-therapeutic-target-of-prospective-medicines-for-obesity
#7
REVIEW
Fan Yao, Ming Zhang, Li Chen
Excessive lipid accumulation in adipose tissue is either the source of obesity or the cause and result of chronic local inflammation, and recent studies indicate that the accumulation may induce many other specialized immunologic features with macrophages and epidemic diseases. We analyze the effective stages of immune cells in adipose tissue, including macrophage recruitment, macrophage polarization, and macrophage-like phenotype preadipocyte possession to find optimal sites as drug targets. Subsequently, some main signaling pathways are summarized in this review, including the AMP-activated protein kinase (AMPK) pathway, the JNK signaling pathway, and a novel one, the Notch signaling pathway...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28459073/therapeutic-effects-of-static-magnetic-field-on-wound-healing-in-diabetic-rats
#8
Jing Zhao, Yong-Guo Li, Kai-Qin Deng, Peng Yun, Ting Gong
Objective. To investigate the effects of static magnetic field (SMF) on cutaneous wound healing of Streptozotocin- (STZ-) induced diabetic rats. Methods. 20 STZ-induced diabetic rats were randomly divided into two groups (10 in each group): diabetic rats with SMF exposure group which were exposed to SMF by gluing one magnetic disk of 230 mT intensity and diabetic rats with sham SMF exposure group (sham group). 10 normal Wistar rats were used as the control group. One open circular wound with 2 cm diameter in the dorsum was generated on both normal and diabetic rats and then covered with sterile gauzes...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28459072/serum-25-hydroxyvitamin-d3-levels-are-associated-with-carotid-intima-media-thickness-and-carotid-atherosclerotic-plaque-in-type-2-diabetic-patients
#9
Yurong Wang, Huijuan Zhang
Objective. To investigate the relationship between serum 25-hydroxyvitamin D3 [25(OH)D3] levels and carotid intima-media thickness (IMT) as well as carotid atherosclerotic plaque in patients with type 2 diabetes mellitus (T2DM). Methods. 314 patients with T2DM were enrolled in this study. The clinical data and laboratory examinations of subjects were recorded, such as serum 25(OH)D3, hemoglobin A1c (HbA1c), serum lipids, fasting blood glucose (FBG), and other biochemical parameters. Color Doppler ultrasound was used to measure carotid IMT and carotid atherosclerotic plaques...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28428964/micrornas-mediated-regulation-of-skeletal-muscle-glut4-expression-and-translocation-in-insulin-resistance
#10
REVIEW
João Victor Esteves, Francisco Javier Enguita, Ubiratan Fabres Machado
The solute carrier family 2 facilitated glucose transporter member 4 (GLUT4) plays a key role in the insulin-induced glucose uptake by muscle and adipose tissues. In prediabetes and diabetes, GLUT4 expression/translocation has been detected as reduced, participating in mechanisms that impair glycemic control. Recently, a class of short endogenous noncoding RNAs named microRNAs (miRNAs) has been increasingly described as involved in the posttranscriptional epigenetic regulation of gene expression. The present review focuses on miRNAs potentially involved in the expression of GLUT4 expression, and proteins related to GLUT4 and translocation in skeletal muscle, seeking to correlate them with insulin resistance and diabetes...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28421206/the-increased-circulating-plasma-levels-of-vascular-endothelial-growth-factor-in-patients-with-type-1-diabetes-do-not-correlate-to-metabolic-control
#11
Kailash Singh, Stellan Sandler, Daniel Espes
Aim. To characterize the plasma levels of vascular endothelial growth factor (VEGF) in type 1 diabetes mellitus (T1D) and its relation to both present and historical metabolic control and microvascular complications. Methods. Plasma levels of VEGF and routine clinical parameters were analyzed in 115 patients with long-standing T1D and 45 healthy controls (HC). All patients were under clinical routine diabetes treatment at Uppsala University Hospital. Results. The plasma levels of VEGF were increased by 37% in patients with T1D when compared to HC (18...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28421205/the-preferential-impairment-of-pupil-constriction-stimulated-by-blue-light-in-patients-with-type-2-diabetes-without-autonomic-neuropathy
#12
Fukashi Ishibashi, Rie Kojima, Miki Taniguchi, Aiko Kosaka, Harumi Uetake, Mitra Tavakoli
The main aim of the present paper is to examine whether the pupillary light reflex (PLR) mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) is impaired in type 2 diabetic patients. One hundred and three diabetic patients without diabetic autonomic neuropathy (DAN) and 42 age-matched controls underwent a series of detailed neurological examinations. The patients were stratified into three groups: stage I, no neuropathy; stage II, asymptomatic neuropathy; stage III, symptomatic but without DAN...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28421204/diabetic-cardiomyopathy-current-approach-and-potential-diagnostic-and-therapeutic-targets
#13
REVIEW
Georgiana-Emmanuela Gilca, Gabriela Stefanescu, Oana Badulescu, Daniela-Maria Tanase, Iris Bararu, Manuela Ciocoiu
Although ischemic heart disease is the major cause of death in diabetic patients, diabetic cardiomyopathy (DCM) is increasingly recognized as a clinically relevant entity. Considering that it comprises a variety of mechanisms and effects on cardiac function, increasing the risk of heart failure and worsening the prognosis of this patient category, DCM represents an important complication of diabetes mellitus, with a silent development in its earlier stages, involving intricate pathophysiological mechanisms, including oxidative stress, defective calcium handling, altered mitochondrial function, remodeling of the extracellular matrix, and consequent deficient cardiomyocyte contractility...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28409163/pgc1%C3%AE-activators-mitigate-diabetic-tubulopathy-by-improving-mitochondrial-dynamics-and-quality-control
#14
So-Young Lee, Jun Mo Kang, Dong-Jin Kim, Seon Hwa Park, Hye Yun Jeong, Yu Ho Lee, Yang Gyun Kim, Dong Ho Yang, Sang Ho Lee
Purpose. In this study, we investigated the effect of PGC1α activators on mitochondrial fusion, fission, and autophagic quality control in renal tubular cells in a diabetic environment in vivo and in vitro. We also examined whether the upregulation of PGC1α attenuates diabetic tubulopathy by normalizing mitochondrial homeostasis. Methods. HKC8 cells were subjected to high-glucose conditions (30 mM D-glucose). Diabetes was induced with streptozotocin (STZ, 50 mg/kg i.p. for 5 days) in male C57/BL6J mice...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28409162/synergistic-effect-of-the-mthfr-c677t-and-ephx2-g860a-polymorphism-on-the-increased-risk-of-ischemic-stroke-in-chinese-type-2-diabetic-patients
#15
Liang Ma, Yongwei Jiang, Xiaomu Kong, Meihua Yan, Tingting Zhao, Hailing Zhao, Qian Liu, Haojun Zhang, Yongtong Cao, Ping Li
The aim of this study was to investigate the relationship between the combined effect of MTHFR C677T (rs1801133) and EPHX2 G860A (rs751141) polymorphism and ischemic stroke in Chinese T2DM patients. This case-control study included a total of 626 Chinese T2DM patients (236 T2DM patients with ischemic stroke and 390 T2DM patients without ischemic stroke). The rs1801133 and rs751141 were genotyped using real-time polymerase chain reaction. Statistical analysis was performed with SPSS 17.0. Results showed that the combined effect of MTHFR TT and EPHX2 GG or GA + AA genotype has a higher risk of ischemic stroke compared with the control group (combined effect of MTHFR CC and EPHX2 GA + AA genotypes; OR = 3...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28409161/corrigendum-to-brain-activation-and-psychomotor-speed-in-middle-aged-patients-with-type-1-diabetes-relationships-with-hyperglycemia-and-brain-small-vessel-disease
#16
Misun Hwang, Dana L Tudorascu, Karen Nunley, Helmet Karim, Howard J Aizenstein, Trevor J Orchard, Caterina Rosano
[This corrects the article DOI: 10.1155/2016/9571464.].
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28409160/peripheral-and-autonomic-neuropathy-in-south-asians-and-white-caucasians-with-type-2-diabetes-mellitus-possible-explanations-for-epidemiological-differences
#17
Abd A Tahrani, Q A Altaf, Milan K Piya, Anthony H Barnett
Objectives. To compare the prevalence of diabetic peripheral neuropathy (DPN) and that of cardiac autonomic neuropathy (CAN) between South Asians and White Caucasians with type 2 diabetes and to explore reasons for observed differences. Methods. A cross-sectional study of casually selected South Asian and White Caucasian adults attending a hospital-based diabetes clinic in the UK. DPN and CAN were assessed using the Michigan Neuropathy Screening Instrument (MNSI) and heart rate variability testing, respectively...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28401170/corrigendum-to-hypoglycemic-activity-through-a-novel-combination-of-fruiting-body-and-mycelia-of-cordyceps-militaris-in-high-fat-diet-induced-type-2-diabetes-mellitus-mice
#18
Sung-Hsun Yu, Szu-Yu Tina Chen, Wei-Shan Li, Navneet Kumar Dubey, Wei-Hong Chen, Jiunn-Jye Chuu, Sy-Jye Leu, Win-Ping Deng
[This corrects the article DOI: 10.1155/2015/723190.].
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28401169/epigenetic-regulations-in-diabetic-nephropathy
#19
REVIEW
Zeyuan Lu, Na Liu, Feng Wang
Diabetic nephropathy (DN) is a chronic complication of diabetes and the most common cause of end-stage kidney disease. It has been reported that multiple factors are involved in the pathogenesis of DN, while the molecular mechanisms that lead to DN are still not fully understood. Numerous risk factors for the development of diabetic nephropathy have been proposed, including ethnicity and inherited genetic differences. Recently, with the development of high-throughput technologies, there is emerging evidence that suggests the important role of epigenetic mechanisms in the pathogenesis of DN...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28401168/the-association-of-a-genetic-variant-in-scaf8-cnksr3-with-diabetic-kidney-disease-and-diabetic-retinopathy-in-a-chinese-population
#20
Li Jin, Tao Wang, Song Jiang, Miao Chen, Rong Zhang, Cheng Hu, Weiping Jia, Zhihong Liu
Background. Genome-wide association studies found rs955333 located in 6q25.2 was associated with diabetic kidney disease in multiple ethnic populations, including European Americans, African Americans, and Mexican Americans. We aimed to investigate the association between the variant rs955333 in SCAF8-CNKSR3 and DKD susceptibility in Chinese type 2 diabetes patients. Methods. The variant rs955333 was genotyped in 1884 Chinese type 2 diabetes patients. Associations of the variant rs955333 with DKD and DR susceptibility and related quantitative traits were evaluated...
2017: Journal of Diabetes Research
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