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Journal of Diabetes Research

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https://www.readbyqxmd.com/read/28634587/exercise-metabolism-in-nonobese-patients-with-type-2-diabetes-following-the-acute-restoration-of-normoglycaemia
#1
Christopher J Gaffney, Peter Mansell, Francis B Stephens, Ian A Macdonald, Kostas Tsintzas
This study investigated how acute restoration of normoglycaemia affected energy metabolism during exercise in nonobese patients with type 2 diabetes. Six subjects (mean ± SEM) aged 56.2 ± 2.7 years, with a BMI of 24.5 ± 1.5 kg/m(2) and a VO2 peak of 28.7 ml/kg/min, attended the lab on two randomised occasions for a four-hour resting infusion of insulin or saline, followed by 30 minutes cycling at 50% VO2 peak. During the 4 h resting infusion, there was a greater (P < 0.0001) reduction in blood glucose in insulin treatment (INS) (from 11...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28634586/the-referral-system-between-primary-and-secondary-health-care-in-saudi-arabia-for-patients-with-type-2-diabetes-a-systematic-review
#2
REVIEW
Mohammed Senitan, Ali Hassan Alhaiti, James Gillespie, Badar Faiz Alotaibi, George Binh Lenon
BACKGROUND: In Saudi Arabia, the mortality of diabetes is currently reported at 6%. A well-administered referral system is crucial in aiding the management of this disease. METHOD: A single reviewer employed a systematic approach to searching the literature databases with regard to the question: what are the attributes of referral systems in Saudi Arabia for patients with type 2 diabetes (T2D)? The results were analysed in order to provide recommendations to improve the Saudi health system...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28634585/high-plasma-glucagon-levels-correlate-with-waist-to-hip-ratio-suprailiac-skinfold-thickness-and-deep-subcutaneous-abdominal-and-intraperitoneal-adipose-tissue-depots-in-nonobese-asian-indian-males-with-type-2-diabetes-in-north-india
#3
Shajith Anoop, Anoop Misra, Surya Prakash Bhatt, Seema Gulati, Harsh Mahajan, Gokulraj Prabakaran
We aimed to correlate plasma glucagon levels with anthropometric measures and abdominal adipose tissue depots. Nonobese males (n = 81; BMI < 25 kg/m(2)) with T2DM of less than one-year duration and nonobese males without diabetes (n = 30) were evaluated for the following: anthropometry (BMI, waist circumference, W-HR, and truncal skinfolds), whole-body DEXA (for body fat and fat-free mass), and MRI scan (for volumes of subcutaneous abdominal adipose tissue (SCAT) including superficial and deep, intra-abdominal visceral adipose tissue (including intraperitoneal adipose tissue (IPAT), retroperitoneal adipose tissue, liver span and fatty liver, and pancreatic volume))...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28626772/leptin-adiponectin-ratios-using-either-total-or-high-molecular-weight-adiponectin-as-biomarkers-of-systemic-insulin-sensitivity-in-normoglycemic-women
#4
Carolina Bravo, Luis Rodrigo Cataldo, José Galgani, Javier Parada, José Luis Santos
Plasma leptin/adiponectin ratio (LAR) is negatively associated with insulin sensitivity indexes. High-molecular-weight adiponectin (HMWA) was proposed as the most biologically active form of this insulin-sensitizing adipokine. There are no studies assessing the relative merits of leptin/HMWA ratio over LAR as a biomarker of systemic insulin sensitivity. A standard 2-hour oral glucose tolerance test (OGTT; 75 g of glucose) and a short minimal-model intravenous glucose tolerance test (IVGTT; 0.3 g/kg body weight) were performed in 58 Chilean normoglycemic women (age: 27 ± 6...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28626771/inadequate-triglyceride-management-worsens-the-durability-of-dipeptidyl-peptidase-4-inhibitor-in-subjects-with-type-2-diabetes-mellitus
#5
Masashi Shimoda, Maiko Miyoshi-Takai, Shintaro Irie, Akihito Tanabe, Atsushi Obata, Seizo Okauchi, Hidenori Hirukawa, Tomohiko Kimura, Kenji Kohara, Shinji Kamei, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
Dipeptidyl peptidase-4 (DPP-4) inhibitors are often used all over the world and exert various beneficial effects including glucose-lowering effect in many subjects with type 2 diabetes. It is poorly understood, however, which factors are closely related with the durability of glucose-lowering effect by DPP-4 inhibitor. In this study, we examined retrospectively which factors could mainly influence the durability of DPP-4 inhibitor. We enrolled 212 participants with type 2 diabetes to whom DPP-4 inhibitor was administered for over 1 year without an addition or increase of other hypoglycemic agents...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28626770/upregulation-of-tumor-necrosis-factor-%C3%AE-induced-protein-8-like-2-mrna-is-negatively-correlated-with-serum-concentrations-of-tumor-necrosis-factor-%C3%AE-and-interleukin-6-in-type-2-diabetes-mellitus
#6
Yongliang Liu, Xinmei Wang, Yan Zhao, Peiqing Zhao, Lianqing Wang, Qiaoli Zhai, Xiaowei Zhang, Wenxiu Tian, Xinxin Xiang, Tao Li
BACKGROUND: Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a negative regulator of natural and adaptive immunity. The role of TIPE2 in type 2 diabetes mellitus (T2DM) remains unknown, although TIPE2 plays key roles in preserving inflammatory homeostasis. METHODS: TIPE2 expression was measured by Western blotting and real-time polymerase chain reaction (RT-PCR) in peripheral blood mononuclear cells (PBMCs) isolated from T2DM patients and healthy controls, and tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), and other related biometabolic parameters were detected using a nephelometer or by ELISA...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28626769/the-effect-of-social-support-on-glycemic-control-in-patients-with-type-2-diabetes-mellitus-the-mediating-roles-of-self-efficacy-and-adherence
#7
Yechang Shao, Lu Liang, Linjing Shi, Chengsong Wan, Shouyi Yu
Ample evidence suggests that social support, self-efficacy, and adherence significantly, independently, and together affect glycemic control in patients with type 2 diabetes mellitus (T2DM), but the pathway from social support to glycemic control remains unclear. This study hypothesized that the effect of social support on glycemic control was mediated sequentially by self-efficacy and adherence. Patients with T2DM were recruited from two hospitals in Guangzhou, China, from January 1 to July 31, 2014, and their sociodemographic clinical data and their assessments on social support, self-efficacy, and adherence were obtained from medical records and self-completed questionnaires...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28620620/ngal-as-an-early-predictive-marker-of-diabetic-nephropathy-in-children-and-young-adults-with-type-1-diabetes-mellitus
#8
Nektaria Papadopoulou-Marketou, Alexandra Margeli, Ioannis Papassotiriou, George P Chrousos, Christina Kanaka-Gantenbein, Jeanette Wahlberg
AIMS: Type 1 diabetes (T1D) is often associated with early microvascular complications. Previous studies demonstrated that increased systolic (SAP) and diastolic arterial blood pressures (DAP) are linked to microvascular morbidity in T1D. The aim of the study was to investigate the predictive role of neutrophil gelatinase-associated lipocalin (NGAL) in unravelling early cardio-renal dysfunction in T1D. METHODS: Two T1D patient groups participating in two-centre prospective cohorts were studied...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28596971/soluble-urokinase-receptor-and-the-kidney-response-in-diabetes-mellitus
#9
REVIEW
Ranadheer R Dande, Vasil Peev, Mehmet M Altintas, Jochen Reiser
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) worldwide. DN typically manifests by glomerular hyperfiltration and microalbuminuria; then, the disease progresses to impaired glomerular filtration rate, which leads to ESRD. Treatment options for DN include the strict control of blood glucose levels and pressure (e.g., intraglomerular hypertension). However, the search for novel therapeutic strategies is ongoing. These include seeking specific molecules that contribute to the development and progression of DN to potentially interfere with these "molecular targets" as well as with the cellular targets within the kidney such as podocytes, which play a major role in the pathogenesis of DN...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28596970/type-2-diabetes-in-young-females-results-in-increased-serum-amyloid-a-and-changes-to-features-of-high-density-lipoproteins-in-both-hdl2-and-hdl3
#10
Kayleigh Griffiths, Agnieszka Pazderska, Mohammed Ahmed, Anne McGowan, Alexander P Maxwell, Jane McEneny, James Gibney, Gareth J McKay
Persons with type 2 diabetes mellitus (T2DM) have an elevated risk of atherosclerosis. High-density lipoproteins (HDL) normally protect against cardiovascular disease (CVD), but this may be attenuated by serum amyloid A (SAA). In a case-control study of young females, blood samples were compared between subjects with T2DM (n = 42) and individuals without T2DM (n = 42). SAA and apolipoprotein AI (apoAI) concentrations, paraoxonase-1 (PON-1), cholesteryl ester transfer protein (CETP), and lecithin-cholesterol acyltransferase (LCAT) activities were measured in the serum and/or HDL2 and HDL3 subfractions...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28584820/the-ldl-receptor-related-protein-1-at-the-crossroads-of-lipoprotein-metabolism-and-insulin-signaling
#11
REVIEW
Dianaly T Au, Dudley K Strickland, Selen C Muratoglu
The metabolic syndrome is an escalating worldwide public health concern. Defined by a combination of physiological, metabolic, and biochemical factors, the metabolic syndrome is used as a clinical guideline to identify individuals with a higher risk for type 2 diabetes and cardiovascular disease. Although risk factors for type 2 diabetes and cardiovascular disease have been known for decades, the molecular mechanisms involved in the pathophysiology of these diseases and their interrelationship remain unclear...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28573146/prevalence-of-positive-diabetes-associated-autoantibodies-among-type-2-diabetes-and-related-metabolic-and-inflammatory-differences-in-a-sample-of-the-bulgarian-population
#12
Emanuela Tsvetkova Zaharieva, Tsvetelina Veselinova Velikova, Adelina Dimitrova Tsakova, Zdravko Asenov Kamenov
BACKGROUND: The study aimed to estimate the prevalence of unrecognized cases with positive autoantibodies among type 2 diabetes (T2D) in a sample of the Bulgarian population and to compare some metabolic and inflammatory markers to those of patients having negative autoantibodies and subjects with latent autoimmune diabetes (LADA). METHODS: Patients with T2D, patients with LADA, and control participants were enrolled. Antiglutamic acid decarboxylase, anti-insulinoma-associated 2, and antizinc transporter 8 autoantibodies were assayed through ELISA...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28573145/cardio-ankle-vascular-index-and-indices-of-diabetic-polyneuropathy-in-patients-with-type-2-diabetes
#13
Akihiko Ando, Michiaki Miyamoto, Kazuhiko Kotani, Kenta Okada, Shoichiro Nagasaka, Shun Ishibashi
The cardio-ankle vascular index (CAVI) is used to test vascular function and is an arterial stiffness marker and potential predictor of cardiovascular events. This study aimed to analyze the relation between objective indices of diabetic polyneuropathy (DPN) and the CAVI. One hundred sixty-six patients with type 2 diabetes mellitus were included in this study. We used nerve conduction studies (NCSs) and the coefficient of variation of the R-R interval to evaluate DPN. We estimated arteriosclerosis by the CAVI...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28567425/the-effectiveness-of-lifestyle-adaptation-for-the-prevention-of-prediabetes-in-adults-a-systematic-review
#14
REVIEW
George Kerrison, Richard B Gillis, Shahwar I Jiwani, Qushmua Alzahrani, Samil Kok, Stephen E Harding, Ian Shaw, Gary G Adams
Diabetes prevalence is increasing exceptionally worldwide and with this come associated healthcare costs. The primary outcome of this systematic review was to assess glycaemic control and incidence of Type 2 diabetes mellitus (T2DM) diagnosis after exercise and dietary intervention (measured with any validated scale). The secondary outcome assessed body mass index change, weight change, and physical exercise capacity after diet and exercise intervention (measured with any validated scale). 1,780 studies were identified from searching electronic databases...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28553654/the-cndp1-ctg-5-polymorphism-is-associated-with-biopsy-proven-diabetic-nephropathy-time-on-hemodialysis-and-diabetes-duration
#15
Thomas Albrecht, Shiqi Zhang, Jana D Braun, Li Xia, Angelica Rodriquez, Jiedong Qiu, Verena Peters, Claus P Schmitt, Jacob van den Born, Stephan J L Bakker, Alexander Lammert, Hannes Köppel, Peter Schnuelle, Bernhard K Krämer, Benito A Yard, Sibylle J Hauske
Considering that the homozygous CNDP1 (CTG)5 genotype affords protection against diabetic nephropathy (DN) in female patients with type 2 diabetes, this study assessed if this association remains gender-specific when applying clinical inclusion criteria (CIC-DN) or biopsy proof (BP-DN). Additionally, it assessed if the prevalence of the protective genotype changes with diabetes duration and time on hemodialysis and if this occurs in association with serum carnosinase (CN-1) activity. Whereas the distribution of the (CTG)5 homozygous genotype in the no-DN and CIC-DN patients was comparable, a lower frequency was found in the BP-DN patients, particularly in females...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28553653/not-only-glycaemic-but-also-other-metabolic-factors-affect-t-regulatory-cell-counts-and-proinflammatory-cytokine-levels-in-women-with-type-1-diabetes
#16
Katerina Stechova, Jana Sklenarova-Labikova, Tereza Kratzerova, Pavlina Pithova, Dominik Filipp
Type 1 diabetic (T1D) patients suffer from insulinopenia and hyperglycaemia. Studies have shown that if a patient's hyperglycaemic environment is not compensated, it leads to complex immune dysfunctions. Similarly, T1D mothers with poor glycaemic control exert a negative impact on the immune responses of their newborns. However, questions concerning the impact of other metabolic disturbances on the immune system of T1D mothers (and their newborns) have been raised. To address these questions, we examined 28 T1D women in reproductive age for the relationship between various metabolic, clinical, and immune parameters...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28540309/diabetes-risk-score-in-a-young-student-population-in-jordan-a-cross-sectional-study
#17
Abdel-Ellah Al-Shudifat, Amjad Al-Shdaifat, Ahmad Ali Al-Abdouh, Mohammad Ibrahim Aburoman, Sara Mohammad Otoum, Amro Ghaleb Sweedan, Ibrahim Khrais, Ibrahim Hisham Abdel-Hafez, Asgeir Johannessen
Background. The Middle East is the home to the most obese population in the world, and type 2 diabetes mellitus is endemic in the region. However, little is known about risk factors for diabetes in the younger age groups. Methods. The Finnish Diabetes Risk Score (FINDRISC) is a simple, validated tool to identify persons at risk of diabetes. We investigated students at Hashemite University in Jordan with FINDRISC and measured fasting plasma glucose in those who were categorized in the high-risk group. Results...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28540308/relationships-between-composition-of-major-fatty-acids-and-fat-distribution-and-insulin-resistance-in-japanese
#18
Chikako Fujii, Toshihide Kawai, Koichiro Azuma, Yuko Oguma, Fuminori Katsukawa, Hiroshi Hirose, Kumiko Tanaka, Shu Meguro, Hideo Matsumoto, Hiroshi Itoh
Objective. The aim of this study was to evaluate the relationships between the composition of free fatty acids (FFAs) and metabolic parameters, including body fat distribution, in Japanese. Methods. The study subjects were 111 Japanese patients (54 males, 57 females). Metabolic parameters and visceral and subcutaneous fat areas as determined by CT scanning at the umbilical level were measured. Glucose tolerance test (GTT) was performed by administering 75 g glucose orally. Results. The percentage of linoleic acid (C18:2), the greatest constituent among FFAs, was negatively correlated with visceral fat area (r = -0...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28529958/spatiotemporal-regulators-for-insulin-stimulated-glut4-vesicle-exocytosis
#19
REVIEW
Xiaoxu Zhou, Ping Shentu, Yingke Xu
Insulin increases glucose uptake and storage in muscle and adipose cells, which is accomplished through the mobilization of intracellular GLUT4 storage vesicles (GSVs) to the cell surface upon stimulation. Importantly, the dysfunction of insulin-regulated GLUT4 trafficking is strongly linked with peripheral insulin resistance and type 2 diabetes in human. The insulin signaling pathway, key signaling molecules involved, and precise trafficking itinerary of GSVs are largely identified. Understanding the interaction between insulin signaling molecules and key regulatory proteins that are involved in spatiotemporal regulation of GLUT4 vesicle exocytosis is of great importance to explain the pathogenesis of diabetes and may provide new potential therapeutic targets...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28512642/role-of-nuclear-factor-erythroid-2-related-factor-2-in-diabetic-nephropathy
#20
REVIEW
Wenpeng Cui, Xu Min, Xiaohong Xu, Bing Du, Ping Luo
Diabetic nephropathy (DN) is manifested as increased urinary protein level, decreased glomerular filtration rate, and final renal dysfunction. DN is the leading cause of end-stage renal disease worldwide and causes a huge societal healthcare burden. Since satisfied treatments are still limited, exploring new strategies for the treatment of this disease is urgently needed. Oxidative stress takes part in the initiation and development of DN. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key role in the cellular response to oxidative stress...
2017: Journal of Diabetes Research
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